Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01841736
First received: April 24, 2013
Last updated: October 30, 2014
Last verified: October 2014
  Purpose

This randomized phase II trial studies how well pazopanib hydrochloride works in treating patients with carcinoid tumors that are growing, spreading, or getting worse. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.


Condition Intervention Phase
Metastatic Gastrointestinal Carcinoid Tumor
Pulmonary Carcinoid Tumor
Recurrent Gastrointestinal Carcinoid Tumor
Recurrent Neuroendocrine Carcinoma of the Skin
Regional Gastrointestinal Carcinoid Tumor
Stage III Neuroendocrine Carcinoma of the Skin
Stage IV Neuroendocrine Carcinoma of the Skin
Thyroid Gland Medullary Carcinoma
Drug: pazopanib hydrochloride
Other: placebo
Other: quality-of-life assessment
Other: laboratory biomarker analysis
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Prospective Randomized Phase II Trial of Pazopanib (NSC # 737754) Versus Placebo in Patients With Progressive Carcinoid Tumors

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Progression-free survival [ Time Frame: From date of patient entry until documented progression of disease or death from any cause, assessed up to 5 years ] [ Designated as safety issue: No ]
    PFS will be estimated within treatment arm using the Kaplan-Meier method.


Secondary Outcome Measures:
  • Objective response rate (ORR), defined as the percentage of patients with a confirmed complete response (CR) or partial response (PR) per RECIST 1.1 criteria [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
    The exact binomial confidence interval will be used to estimate ORR.

  • Overall survival (OS) [ Time Frame: From randomization until death from any cause, assessed up to 5 years ] [ Designated as safety issue: No ]
    OS will be estimated by the Kaplan-Meier method within each treatment arm.

  • Duration of response (DR) for the subset of patients with a confirmed CR or PR [ Time Frame: From first documented evidence of CR or PR until first documented disease progression or death from any cause, assessed up to 5 years ] [ Designated as safety issue: No ]
    DR will be summarized descriptively using Kaplan-Meier medians and quartiles.

  • Time to treatment failure [ Time Frame: From randomization until termination of protocol therapy for any reason including progression of disease, adverse events, and death, assessed up to 5 years ] [ Designated as safety issue: No ]
  • Time to second progression for patients who crossover from placebo to active therapy [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 165
Study Start Date: June 2013
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (pazopanib hydrochloride)
Patients receive pazopanib hydrochloride PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug: pazopanib hydrochloride
Given PO
Other Names:
  • GW786034B
  • Votrient
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Other: laboratory biomarker analysis
Correlative studies
Placebo Comparator: Arm II (placebo)
Patients receive placebo PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I.
Other: placebo
Given PO
Other Name: PLCB
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Other: laboratory biomarker analysis
Correlative studies

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Low- or intermediate-grade neuroendocrine carcinoma, including the following subtypes: carcinoid tumor, low- to intermediate-grade or well- to moderately-differentiated neuroendocrine carcinoma or tumor, atypical carcinoid tumor; documentation from a primary tumor or metastatic site is sufficient; patients with poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma, adenocarcinoid tumor, or goblet cell carcinoid tumor are not eligible
  • Locally unresectable or metastatic carcinoid tumors
  • Patients must have histologic documentation or clinical evidence of a carcinoid tumor of primary site (including foregut, midgut, hindgut or other non-pancreatic site); tumors of unknown primary site are eligible provided the treating physician does not suspect medullary thyroid cancer, pancreatic neuroendocrine tumor, paraganglioma, or pheochromocytoma; unknown primary tumors will be classified as small bowel tumors for the purpose of stratification; functional (associated with a clinical syndrome) or nonfunctional tumors are allowed; target lesions must have shown disease progression if therapy included peptide receptor radiotherapy (PRRT) and PRRT must be completed at least 8 weeks prior to registration
  • Radiological evidence for progressive disease (measureable or non-measurable) within 12 months prior to registration; patients who have received anti-tumor therapy during the past 12 months (including octreotide analogs) must have had radiological documentation of progression of disease while on or after receiving therapy
  • No known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; patients with lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching, but not infiltrating (abutting) the vessels is acceptable (computed tomography [CT] with contrast is strongly recommended to evaluate such lesions); patients with large protruding endobronchial lesions in the main or lobar brochi are excluded; however, endobronchial lesions in the segmented bronchi are allowed
  • Patients must have measurable disease per RECIST 1.1 by computed tomography (CT) scan or magnetic resonance imaging (MRI); lesions must be accurately measured in at least one dimension (longest diameter to be recorded) as >= 1 cm with CT or MRI (or >= 1.5 cm for lymph nodes)
  • No prior treatment with an inhibitor of vascular endothelial growth factor (VEGF) or vascular endothelial growth factor receptor (VEGFR)
  • Prior treatment (somatostatin analogs excepted) must be completed at least 2 weeks prior to registration; in addition, prior treatment (somatostatin analogs excepted) must be completed at least 4 weeks prior to initiation of study drug; treatment-related toxicities must have improved to =< grade 1 prior to registration, with the exception of alopecia
  • Concurrent use of somatostatin analogs (SSTa) is allowed, provided that the patient is on a stable dose for at least two months and progressive disease on somatostatin analog has been documented; progression on octreotide is required for patients with tumors arising in the midgut
  • Prior treatment with embolization (including bland embolization, chemoembolization, and selective internal radiation therapy) or ablative therapies is allowed if measurable disease remains outside of the treated area or there is documented disease progression in a treated site; there is no limit on the prior number of procedures; prior liver-directed or other ablative treatment must be completed at least 8 weeks prior to registration
  • Patients should have completed any major surgery >= 4 weeks prior to registration and must have completed any minor surgery >= 2 weeks prior to registration; patients must have fully recovered from the procedure

    • The following are examples of procedures considered to be minor: port placement, laparoscopy, thoracoscopy, bronchoscopy, mediastinoscopy, skin biopsies, incisional biopsies, imaging-guided biopsy for diagnostic purposes, and dental extraction procedures
    • Insertion of a vascular access device, thoracentesis, paracentesis, and endoscopic ultrasonographic procedures are not considered to be major or minor surgeries
  • No concurrent condition resulting in immune compromise, including chronic treatment with corticosteroids or other immunosuppressive agents
  • No clinical evidence of central nervous system (CNS) metastases (including carcinomatous meningitis) at baseline, with the exception of those patients who have previously-treated CNS metastases (surgery +/- radiotherapy, radiosurgery, or gamma knife) and who meet both of the following criteria: a) are asymptomatic and b) had no requirement for steroids or enzyme-inducing anticonvulsants within 6 months prior to registration
  • No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to registration
  • No clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding within 28 days prior to registration including, but not limited to:

    • Active peptic ulcer
    • Known endoluminal metastatic lesion(s) with history of bleeding
    • Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other gastrointestinal conditions with increased risk of perforation
  • No history of serious (i.e., requiring active medical therapy with medication or medical device under the supervision of a physician) non-healing wound, ulcer, trauma, or bone fracture within 28 days prior to study entry
  • Patients with a history of hypertension must have blood pressure that is adequately controlled on antihypertensives; (< 140/90 mmHg)
  • No symptomatic congestive heart failure (New York Heart Association class II, III, or IV) within 6 months prior to registration
  • No arterial thrombotic events within 6 months of registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, myocardial infarction (MI), or unstable angina or angina requiring surgical or medical intervention in 6 months prior to registration; patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are ineligible; patients who have experienced a deep venous thrombosis or pulmonary embolus within 6 months prior to registration must be on stable therapeutic anticoagulation for at least 6 weeks prior to enrollment of this study
  • Patients on therapeutic anticoagulation with low molecular weight heparins, fondaparinux, rivaroxaban or warfarin are eligible, provided that they are on a stable dose of anticoagulants; patients who are currently receiving antiplatelet therapy of prasugrel or clopidogrel or antiaggregation agents (e.g., eptifibatide, epoprostenol, dipyridamole) or low doses of acetylsalicylic acid (up to 100 mg daily) are also eligible
  • No ongoing cardiac dysrhythmias, atrial fibrillation, or prolongation of corrected QT (QTc) interval to > 480 msec
  • No evidence of active bleeding, bleeding diathesis, or hemoptysis (>= 1/2 teaspoon of red blood) within 8 weeks prior to registration
  • No currently unstable angina and/or uncontrolled cardiac arrhythmias
  • Patients with symptomatic peripheral vascular disease are ineligible
  • Ejection fraction on echocardiogram (Echo) or multi gated acquisition scan (MUGA) > 50%
  • Chronic concomitant treatment with strong inhibitors of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) is not allowed on this trial; patients on strong CYP3A4 inhibitors must discontinue the drug 14 days prior to the start of study treatment
  • Women must not be pregnant or nursing; women of child bearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 72 hours prior to registration; women of child-bearing potential include any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea >= 12 consecutive months; or women on hormone replacement therapy [HRT] with documented serum follicle stimulating hormone [FSH] level > 35 mIU/mL)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  • Granulocytes >= 1,500/mcL
  • Platelets >= 100,000/mcL
  • International normalized ratio (INR) =< 1.2 X upper limit of normal (ULN); only required for patients receiving anticoagulant therapy; patients are eligible if their INR is stable and within the recommended range for the desired level of anticoagulation
  • QTc =< 480 msecs
  • Thyroid stimulating hormone (TSH) within normal limits (WNL); medications for thyroid dysfunction are allowed as long as TSH is normal at registration; in patients with abnormal TSH, if the free thryoxine (free T4) and free thyroxine index (FTI) are normal and patient is clinically euthyroid, patient is eligible
  • Bilirubin =< 1.5 x ULN
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) & alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 X ULN are NOT permitted; also, if liver metastases are present, AST & ALT =< 5 x ULN is allowed
  • Serum creatinine =< 1.5 x ULN
  • Urine protein to creatinine (UPC) ratio < 1, or, 24-hour urine protein < 1 g; if UPC >= 1, then a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptable
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01841736

  Hide Study Locations
Locations
United States, Alaska
Katmai Oncology Group Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Women's Cancer Care Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Breast Care and Surgery LLC Active, not recruiting
Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center Active, not recruiting
Anchorage, Alaska, United States, 99508
Anchorage Oncology Centre Active, not recruiting
Anchorage, Alaska, United States, 99508
United States, California
Kaiser Permanente Medical Group - Baldwin Park Active, not recruiting
Baldwin Park, California, United States, 91706
University of Southern California/Norris Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Syma Iqbal    323-865-0451      
Principal Investigator: Syma Iqbal         
Cedars-Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Edward M. Wolin    859-257-3379      
Principal Investigator: Edward M. Wolin         
Los Angeles County-USC Medical Center Active, not recruiting
Los Angeles, California, United States, 90033
Palo Alto Medical Foundation Health Care Active, not recruiting
Palo Alto, California, United States, 94301
Kaiser Permanente Active, not recruiting
San Diego, California, United States, 92120
Kaiser Permanente at San Diego Active, not recruiting
San Diego, California, United States, 92120
UCSF Medical Center-Mount Zion Recruiting
San Francisco, California, United States, 94115
Contact: Emily K. Bergsland    877-827-3222      
Principal Investigator: Emily K. Bergsland         
Kaiser Permanente Health Care Active, not recruiting
San Marcos, California, United States, 92069
Stanford University Hospitals and Clinics Active, not recruiting
Stanford, California, United States, 94305
Palo Atlo Medical Foundation-Sunnyvale Active, not recruiting
Sunnyvale, California, United States, 94806
United States, Colorado
The Medical Center of Aurora Active, not recruiting
Aurora, Colorado, United States, 80012
Boulder Community Hospital Active, not recruiting
Boulder, Colorado, United States, 80301
Rocky Mountain Cancer Centers-Boulder Active, not recruiting
Boulder, Colorado, United States, 80304
Penrose-Saint Francis Healthcare Active, not recruiting
Colorado Springs, Colorado, United States, 80907
Rocky Mountain Cancer Centers-Penrose Active, not recruiting
Colorado Springs, Colorado, United States, 80907
Rose Medical Center Active, not recruiting
Denver, Colorado, United States, 80220
Exempla Saint Joseph Hospital Active, not recruiting
Denver, Colorado, United States, 80218
Presbyterian - Saint Lukes Medical Center - Health One Active, not recruiting
Denver, Colorado, United States, 80218
Rocky Mountain Cancer Centers-Midtown Active, not recruiting
Denver, Colorado, United States, 80218
Porter Adventist Hospital Active, not recruiting
Denver, Colorado, United States, 80210
Colorado Cancer Research Program CCOP Active, not recruiting
Denver, Colorado, United States, 80224-2522
Colorado Blood Cancer Institute Active, not recruiting
Denver, Colorado, United States, 80907
Rocky Mountain Cancer Centers-Rose Active, not recruiting
Denver, Colorado, United States, 80220
Mercy Medical Center Active, not recruiting
Durango, Colorado, United States, 81301
Comprehensive Cancer Care and Research Institute of Colorado LLC Active, not recruiting
Englewood, Colorado, United States, 80113
Swedish Medical Center Active, not recruiting
Englewood, Colorado, United States, 80113
Front Range Cancer Specialists Withdrawn
Fort Collins, Colorado, United States, 80528
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Steven R. Schuster    507-538-7623      
Principal Investigator: Steven R. Schuster         
Mountain Blue Cancer Care Center Active, not recruiting
Golden, Colorado, United States, 80401
North Colorado Medical Center Active, not recruiting
Greeley, Colorado, United States, 80631
Breast Cancer Care Consultants Active, not recruiting
Greenwood Village, Colorado, United States, 80111
Saint Anthony Hospital Active, not recruiting
Lakewood, Colorado, United States, 80228
Rocky Mountain Cancer Centers-Lakewood Active, not recruiting
Lakewood, Colorado, United States, 80228
Littleton Adventist Hospital Active, not recruiting
Littleton, Colorado, United States, 80122
Rocky Mountain Cancer Centers-Sky Ridge Active, not recruiting
Lone Tree, Colorado, United States, 80124
Sky Ridge Medical Center Active, not recruiting
Lone Tree, Colorado, United States, 80124
Rocky Mountain Cancer Centers-Longmont Active, not recruiting
Longmont, Colorado, United States, 80501
Longmont United Hospital Active, not recruiting
Longmont, Colorado, United States, 80501
McKee Medical Center Active, not recruiting
Loveland, Colorado, United States, 80539
Parker Adventist Hospital Active, not recruiting
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers-Parker Active, not recruiting
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers - Pueblo Active, not recruiting
Pueblo, Colorado, United States, 81008
Saint Mary Corwin Medical Center Active, not recruiting
Pueblo, Colorado, United States, 81004
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Saint Francis Hospital and Medical Center Active, not recruiting
Hartford, Connecticut, United States, 06105
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Delaware Clinical and Laboratory Physicians PA Active, not recruiting
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Christiana Gynecologic Oncology LLC Active, not recruiting
Newark, Delaware, United States, 19713
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Nanticoke Memorial Hospital Recruiting
Seaford, Delaware, United States, 19973
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Christiana Care Health System-Wilmington Hospital Active, not recruiting
Wilmington, Delaware, United States, 19801
United States, Florida
Moffitt Cancer Center Recruiting
Tampa, Florida, United States, 33612
Contact: Jonathan R. Strosberg    800-456-7121    canceranswers@moffitt.org   
Principal Investigator: Jonathan R. Strosberg         
United States, Georgia
John B Amos Cancer Center Recruiting
Columbus, Georgia, United States, 31904
Contact: Andrew W. Pippas    706-660-6404      
Principal Investigator: Andrew W. Pippas         
Memorial University Medical Center Active, not recruiting
Savannah, Georgia, United States, 31404
United States, Hawaii
Pali Momi Medical Center Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-Pali Momi Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Kapiolani Medical Center for Women and Children Recruiting
Honolulu, Hawaii, United States, 96826
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-Kuakini Active, not recruiting
Honolulu, Hawaii, United States, 96817
Straub Clinic and Hospital Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
University of Hawaii Cancer Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
OnCare Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817-3169
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-POB II Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Castle Medical Center Terminated
Kailua, Hawaii, United States, 96734
Wilcox Memorial Hospital and Kauai Medical Clinic Recruiting
Lihue, Hawaii, United States, 96766
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Active, not recruiting
Boise, Idaho, United States, 83706
Kootenai Cancer Center Active, not recruiting
Post Falls, Idaho, United States, 83854
United States, Illinois
Northwestern University Active, not recruiting
Chicago, Illinois, United States, 60611
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Manish R. Sharma    773-834-7424      
Principal Investigator: Manish R. Sharma         
Ingalls Memorial Hospital Active, not recruiting
Harvey, Illinois, United States, 60426
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Janelle M. Meyer    708-226-4357      
Principal Investigator: Janelle M. Meyer         
Good Samaritan Regional Health Center Active, not recruiting
Mount Vernon, Illinois, United States, 62864
United States, Indiana
Michiana Hematology Oncology PC-Elkhart Active, not recruiting
Elkhart, Indiana, United States, 46514
Elkhart General Hospital Terminated
Elkhart, Indiana, United States, 46515
Elkhart Clinic Terminated
Elkhart, Indiana, United States, 46514-2098
Indiana University Medical Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Paul R. Helft    317-274-2552      
Principal Investigator: Paul R. Helft         
Community Howard Regional Health Terminated
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Terminated
La Porte, Indiana, United States, 46350
Saint Joseph Regional Medical Center-Mishawaka Active, not recruiting
Mishawaka, Indiana, United States, 46545-1470
Michiana Hematology Oncology PC-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology PC-Plymouth Active, not recruiting
Plymouth, Indiana, United States, 46563
Reid Hospital and Health Care Services Active, not recruiting
Richmond, Indiana, United States, 47374
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Northern Indiana Cancer Research Consortium Active, not recruiting
South Bend, Indiana, United States, 46628
Michiana Hematology Oncology PC-South Bend Active, not recruiting
South Bend, Indiana, United States, 46601
South Bend Clinic Terminated
South Bend, Indiana, United States, 46617
Michiana Hematology Oncology-PC Westville Active, not recruiting
Westville, Indiana, United States, 46391
United States, Iowa
Mary Greeley Medical Center Active, not recruiting
Ames, Iowa, United States, 50010
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Hematology Oncology Associates-Quad Cities Active, not recruiting
Bettendorf, Iowa, United States, 52722
McFarland Clinic PC-Boone Active, not recruiting
Boone, Iowa, United States, 50036
Cedar Rapids Oncology Association Terminated
Cedar Rapids, Iowa, United States, 52403
Mercy Hospital Active, not recruiting
Cedar Rapids, Iowa, United States, 52403
Oncology Associates at Mercy Medical Center Active, not recruiting
Cedar Rapids, Iowa, United States, 52403
Medical Oncology and Hematology Associates-West Des Moines Active, not recruiting
Clive, Iowa, United States, 50325
Mercy Cancer Center-West Lakes Active, not recruiting
Clive, Iowa, United States, 50325
Mercy Medical Center - Des Moines Active, not recruiting
Des Moines, Iowa, United States, 50314
Medical Oncology and Hematology Associates-Des Moines Active, not recruiting
Des Moines, Iowa, United States, 50309
Iowa Oncology Research Association CCOP Active, not recruiting
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Laurel Active, not recruiting
Des Moines, Iowa, United States, 50314
Iowa Methodist Medical Center Active, not recruiting
Des Moines, Iowa, United States, 50309
Iowa Lutheran Hospital Active, not recruiting
Des Moines, Iowa, United States, 50316
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Daniel A. Vaena    800-237-1225      
Principal Investigator: Daniel A. Vaena         
McFarland Clinic PC-Jefferson Active, not recruiting
Jefferson, Iowa, United States, 50129
McFarland Clinic PC-Marshalltown Active, not recruiting
Marshalltown, Iowa, United States, 50158
Mercy Medical Center-Sioux City Terminated
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Active, not recruiting
Sioux City, Iowa, United States, 51101
Saint Luke's Regional Medical Center Terminated
Sioux City, Iowa, United States, 51104
Mercy Medical Center-West Lakes Active, not recruiting
West Des Moines, Iowa, United States, 50266
Methodist West Hospital Active, not recruiting
West Des Moines, Iowa, United States, 50266-7700
United States, Kansas
Newman Regional Health Active, not recruiting
Emporia, Kansas, United States, 66801
Saint Catherine Hospital Active, not recruiting
Garden City, Kansas, United States, 67846
Saint Rose Ambulatory and Surgery Center Active, not recruiting
Great Bend, Kansas, United States, 67530
Hays Medical Center Active, not recruiting
Hays, Kansas, United States, 67601
Kansas City Cancer Center-West Active, not recruiting
Kansas City, Kansas, United States, 66112
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Saint Luke's South Hospital Active, not recruiting
Overland Park, Kansas, United States, 66213
Kansas City Cancer Centers-Southwest Recruiting
Overland Park, Kansas, United States, 66210
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Menorah Medical Center Active, not recruiting
Overland Park, Kansas, United States, 66209
Via Christi Hospital-Pittsburg Active, not recruiting
Pittsburg, Kansas, United States, 66762
Kansas City CCOP Terminated
Prairie Village, Kansas, United States, 66208
Salina Regional Health Center Recruiting
Salina, Kansas, United States, 67401
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Saint Francis Hospital and Medical Center - Topeka Active, not recruiting
Topeka, Kansas, United States, 66606
Cancer Center of Kansas - Main Office Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Oncology Hematology Care Inc-Crestview Active, not recruiting
Crestview Hills, Kentucky, United States, 41017
Hardin Memorial Hospital Active, not recruiting
Elizabethtown, Kentucky, United States, 42701
Baptist Health Lexington Active, not recruiting
Lexington, Kentucky, United States, 40503
United States, Louisiana
Ochsner Health Center-Summa Active, not recruiting
Baton Rouge, Louisiana, United States, 70809
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Jyotsna Fuloria    888-562-4763      
Principal Investigator: Jyotsna Fuloria         
United States, Michigan
Hickman Cancer Center Active, not recruiting
Adrian, Michigan, United States, 49221
Bixby Medical Center Active, not recruiting
Adrian, Michigan, United States, 49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Terminated
Ann Arbor, Michigan, United States, 48106
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Tareq Al Baghdadi    734-712-4673      
Principal Investigator: Tareq Al Baghdadi         
Bronson Battle Creek Active, not recruiting
Battle Creek, Michigan, United States, 49017
Oakwood Hospital and Medical Center Active, not recruiting
Dearborn, Michigan, United States, 48124
Saint John Hospital and Medical Center Active, not recruiting
Detroit, Michigan, United States, 48236
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Hurley Medical Center Active, not recruiting
Flint, Michigan, United States, 48502
Genesys Hurley Cancer Institute Active, not recruiting
Flint, Michigan, United States, 48503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Grand Rapids Clinical Oncology Program Terminated
Grand Rapids, Michigan, United States, 49503
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Allegiance Health Active, not recruiting
Jackson, Michigan, United States, 49201
Sparrow Hospital Active, not recruiting
Lansing, Michigan, United States, 48912
Saint Mary Mercy Hospital Active, not recruiting
Livonia, Michigan, United States, 48154
Mercy Memorial Hospital Terminated
Monroe, Michigan, United States, 48162
Community Cancer Center of Monroe Active, not recruiting
Monroe, Michigan, United States, 48162
Mercy Health Mercy Campus Active, not recruiting
Muskegon, Michigan, United States, 49444
Lakeland Community Hospital Active, not recruiting
Niles, Michigan, United States, 49120
Saint Joseph Mercy Oakland Active, not recruiting
Pontiac, Michigan, United States, 48341-2985
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Tareq Al Baghdadi    734-712-4673      
Principal Investigator: Tareq Al Baghdadi         
Spectrum Health Reed City Hospital Active, not recruiting
Reed City, Michigan, United States, 49677
Saint Mary's of Michigan Active, not recruiting
Saginaw, Michigan, United States, 48601
Marie Yeager Cancer Center Active, not recruiting
Saint Joseph, Michigan, United States, 49085
Lakeland Hospital Active, not recruiting
St. Joseph, Michigan, United States, 49085
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint John Macomb-Oakland Hospital Active, not recruiting
Warren, Michigan, United States, 48093
United States, Minnesota
Fairview Ridges Hospital Active, not recruiting
Burnsville, Minnesota, United States, 55337
Mercy Hospital Active, not recruiting
Coon Rapids, Minnesota, United States, 55433
Essentia Health Saint Mary's Medical Center Active, not recruiting
Duluth, Minnesota, United States, 55805
Miller-Dwan Hospital Active, not recruiting
Duluth, Minnesota, United States, 55805
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Active, not recruiting
Edina, Minnesota, United States, 55435
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Hutchinson Area Health Care Active, not recruiting
Hutchinson, Minnesota, United States, 55350
Minnesota Oncology Hematology PA-Maplewood Active, not recruiting
Maplewood, Minnesota, United States, 55109
Saint John's Hospital - Healtheast Active, not recruiting
Maplewood, Minnesota, United States, 55109
Hennepin County Medical Center Active, not recruiting
Minneapolis, Minnesota, United States, 55415
Abbott-Northwestern Hospital Active, not recruiting
Minneapolis, Minnesota, United States, 55407
New Ulm Medical Center Active, not recruiting
New Ulm, Minnesota, United States, 56073
North Memorial Medical Health Center Active, not recruiting
Robbinsdale, Minnesota, United States, 55422
Park Nicollet Clinic - Saint Louis Park Active, not recruiting
Saint Louis Park, Minnesota, United States, 55416
Metro-Minnesota CCOP Terminated
Saint Louis Park, Minnesota, United States, 55416
United Hospital Active, not recruiting
Saint Paul, Minnesota, United States, 55102
Regions Hospital Active, not recruiting
Saint Paul, Minnesota, United States, 55101
Saint Francis Regional Medical Center Active, not recruiting
Shakopee, Minnesota, United States, 55379
Lakeview Hospital Active, not recruiting
Stillwater, Minnesota, United States, 55082
Ridgeview Medical Center Active, not recruiting
Waconia, Minnesota, United States, 55387
Rice Memorial Hospital Active, not recruiting
Willmar, Minnesota, United States, 56201
Minnesota Oncology and Hematology PA-Woodbury Active, not recruiting
Woodbury, Minnesota, United States, 55125
United States, Missouri
CoxHealth Cancer Center Active, not recruiting
Branson, Missouri, United States, 65616
Southeast Cancer Center Active, not recruiting
Cape Girardeau, Missouri, United States, 63703
University of Missouri - Ellis Fischel Active, not recruiting
Columbia, Missouri, United States, 65212
Centerpoint Medical Center LLC Active, not recruiting
Independence, Missouri, United States, 64057
Capital Region Medical Center-Goldschmidt Cancer Center Active, not recruiting
Jefferson City, Missouri, United States, 65109
Mercy Hospital-Joplin Active, not recruiting
Joplin, Missouri, United States, 64804
Truman Medical Center Recruiting
Kansas City, Missouri, United States, 64108
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Kansas City Cancer Center - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Research Medical Center Active, not recruiting
Kansas City, Missouri, United States, 64132
Saint Luke's Hospital of Kansas City Active, not recruiting
Kansas City, Missouri, United States, 64111
Heartland Hematology and Oncology Associates Incorporated Active, not recruiting
Kansas City, Missouri, United States, 64118
Saint Luke's East - Lee's Summit Active, not recruiting
Lee's Summit, Missouri, United States, 64086
Kansas City Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Mazin F. Al-kasspooles    913-588-4709      
Principal Investigator: Mazin F. Al-kasspooles         
Liberty Radiation Oncology Center Active, not recruiting
Liberty, Missouri, United States, 64068
Phelps County Regional Medical Center Active, not recruiting
Rolla, Missouri, United States, 65401
Saint John's Clinic-Rolla-Cancer and Hematology Active, not recruiting
Rolla, Missouri, United States, 65401
Heartland Regional Medical Center Active, not recruiting
Saint Joseph, Missouri, United States, 64506
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Benjamin R. Tan    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Benjamin R. Tan         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Missouri Baptist Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63131
Saint Louis Cancer and Breast Institute-South City Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Terminated
Springfield, Missouri, United States, 65804
Mercy Hospital Springfield Active, not recruiting
Springfield, Missouri, United States, 65804
CoxHealth South Hospital Active, not recruiting
Springfield, Missouri, United States, 65807
United States, Montana
Montana Cancer Consortium CCOP Active, not recruiting
Billings, Montana, United States, 59101
Saint Vincent Healthcare Active, not recruiting
Billings, Montana, United States, 59101
Billings Clinic Active, not recruiting
Billings, Montana, United States, 59107-7000
Bozeman Deaconess Hospital Active, not recruiting
Bozeman, Montana, United States, 59715
Saint James Community Hospital and Cancer Treatment Center Active, not recruiting
Butte, Montana, United States, 59701
Benefis Healthcare- Sletten Cancer Institute Active, not recruiting
Great Falls, Montana, United States, 59405
Saint Peter's Community Hospital Active, not recruiting
Helena, Montana, United States, 59601
Kalispell Regional Medical Center Active, not recruiting
Kalispell, Montana, United States, 59901
Saint Patrick Hospital - Community Hospital Active, not recruiting
Missoula, Montana, United States, 59802
United States, Nebraska
Nebraska Cancer Research Center Active, not recruiting
Lincoln, Nebraska, United States, 68510
Alegent Health Lakeside Hospital Active, not recruiting
Omaha, Nebraska, United States, 68130
Missouri Valley Cancer Consortium Active, not recruiting
Omaha, Nebraska, United States, 68106
Alegent Health Bergan Mercy Medical Center Active, not recruiting
Omaha, Nebraska, United States, 68124
Nebraska Methodist Hospital Active, not recruiting
Omaha, Nebraska, United States, 68114
Alegent Health Immanuel Medical Center Active, not recruiting
Omaha, Nebraska, United States, 68122
Creighton University Medical Center Terminated
Omaha, Nebraska, United States, 68131
United States, Nevada
Comprehensive Cancer Centers of Nevada-Southeast Henderson Active, not recruiting
Henderson, Nevada, United States, 89074
Las Vegas Cancer Center-Henderson Active, not recruiting
Henderson, Nevada, United States, 89052
21st Century Oncology - Henderson Active, not recruiting
Henderson, Nevada, United States, 89074
Comprehensive Cancer Centers of Nevada - Henderson Active, not recruiting
Henderson, Nevada, United States, 89052
Cancer and Blood Specialists-Henderson Active, not recruiting
Henderson, Nevada, United States, 89052
Nevada Cancer Research Foundation CCOP Active, not recruiting
Las Vegas, Nevada, United States, 89106
University Medical Center of Southern Nevada Active, not recruiting
Las Vegas, Nevada, United States, 89102
Cancer and Blood Specialists-Tenaya Active, not recruiting
Las Vegas, Nevada, United States, 89128
Cancer and Blood Specialists-Shadow Active, not recruiting
Las Vegas, Nevada, United States, 89106
Radiation Oncology Centers of Nevada Central Active, not recruiting
Las Vegas, Nevada, United States, 89106
Radiation Oncology Centers of Nevada Southeast Active, not recruiting
Las Vegas, Nevada, United States, 89119
21st Century Oncology - Vegas Sunrise Active, not recruiting
Las Vegas, Nevada, United States, 89109
Cancer and Blood Specialists-Fort Apache Active, not recruiting
Las Vegas, Nevada, United States, 89148
21st Century Oncology - Fort Apache Active, not recruiting
Las Vegas, Nevada, United States, 89148
21st Century Oncology - Vegas Tenaya Active, not recruiting
Las Vegas, Nevada, United States, 89182
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Active, not recruiting
Las Vegas, Nevada, United States, 89149
Comprehensive Cancer Centers of Nevada-Summerlin Active, not recruiting
Las Vegas, Nevada, United States, 89144
Comprehensive Cancer Centers of Nevada - Central Valley Active, not recruiting
Las Vegas, Nevada, United States, 89169
Cancer Therapy and Integrative Medicine Active, not recruiting
Las Vegas, Nevada, United States, 89121
Comprehensive Cancer Centers of Nevada Active, not recruiting
Las Vegas, Nevada, United States, 89148
Comprehensive Cancer Centers of Nevada - Northwest Active, not recruiting
Las Vegas, Nevada, United States, 89128
Las Vegas Cancer Center-Medical Center Active, not recruiting
Las Vegas, Nevada, United States, 89148-2405
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Active, not recruiting
Las Vegas, Nevada, United States, 89109
HealthCare Partners Medical Group Oncology/Hematology-San Martin Active, not recruiting
Las Vegas, Nevada, United States, 89113
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Active, not recruiting
Las Vegas, Nevada, United States, 89128
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: J. M. Pipas    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: J. M. Pipas         
United States, New Jersey
Cooper Hospital University Medical Center Active, not recruiting
Camden, New Jersey, United States, 08103
United States, New Mexico
University of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Fa-Chyi Lee    505-272-6972      
Principal Investigator: Fa-Chyi Lee         
United States, New York
Montefiore Medical Center-Einstein Campus Active, not recruiting
Bronx, New York, United States, 10461
Montefiore Medical Center - Moses Campus Active, not recruiting
Bronx, New York, United States, 10467-2490
Glens Falls Hospital Active, not recruiting
Glens Falls, New York, United States, 12801
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
Syracuse Veterans Administration Medical Center Recruiting
Syracuse, New York, United States, 13210
Contact: Ajeet Gajra    315-425-2707      
Principal Investigator: Ajeet Gajra         
United States, North Carolina
University of North Carolina Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Stephen A. Bernard    877-668-0683    cancerclinicaltrials@med.unc.edu   
Principal Investigator: Stephen A. Bernard         
Wayne Memorial Hospital Active, not recruiting
Goldsboro, North Carolina, United States, 27534
Margaret R Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford    828-696-4716      
Principal Investigator: James E. Radford         
Hendersonville Hematology and Oncology at Pardee Active, not recruiting
Hendersonville, North Carolina, United States, 28739
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Iredell Memorial Hospital Active, not recruiting
Statesville, North Carolina, United States, 28677
United States, North Dakota
Essentia Health Cancer Center-South University Clinic Active, not recruiting
Fargo, North Dakota, United States, 58103
United States, Ohio
Strecker Cancer Center-Belpre Active, not recruiting
Belpre, Ohio, United States, 45714
Toledo Clinic Cancer Centers-Bowling Green Terminated
Bowling Green, Ohio, United States, 43402
Adena Regional Medical Center Active, not recruiting
Chillicothe, Ohio, United States, 45601
Oncology and Hematology Care Inc-Taft Active, not recruiting
Cincinnati, Ohio, United States, 45219
Oncology Hematology Care Inc-Mercy West Active, not recruiting
Cincinnati, Ohio, United States, 45211
Oncology Hematology Care Inc - Anderson Active, not recruiting
Cincinnati, Ohio, United States, 45230
Oncology Hematology Care Inc-Blue Ash Active, not recruiting
Cincinnati, Ohio, United States, 45242
Oncology Hematology Care Inc - Kenwood Active, not recruiting
Cincinnati, Ohio, United States, 45236
Case Western Reserve University Active, not recruiting
Cleveland, Ohio, United States, 44106
Riverside Methodist Hospital Active, not recruiting
Columbus, Ohio, United States, 43214
Columbus CCOP Terminated
Columbus, Ohio, United States, 43215
Mount Carmel Health Center West Active, not recruiting
Columbus, Ohio, United States, 43222
The Mark H Zangmeister Center Active, not recruiting
Columbus, Ohio, United States, 43219
Doctors Hospital Active, not recruiting
Columbus, Ohio, United States, 43228
Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Manisha H. Shah    866-627-7616    osu@emergingmed.com   
Principal Investigator: Manisha H. Shah         
Columbus Oncology and Hematology Associates Inc Active, not recruiting
Columbus, Ohio, United States, 43214
Grant Medical Center Active, not recruiting
Columbus, Ohio, United States, 43215
Good Samaritan Hospital - Dayton Active, not recruiting
Dayton, Ohio, United States, 45406
Miami Valley Hospital Active, not recruiting
Dayton, Ohio, United States, 45409
Dayton CCOP Terminated
Dayton, Ohio, United States, 45420
Samaritan North Health Center Active, not recruiting
Dayton, Ohio, United States, 45415
Delaware Health Center-Grady Cancer Center Active, not recruiting
Delaware, Ohio, United States, 43015
Delaware Radiation Oncology Active, not recruiting
Delaware, Ohio, United States, 43015
Grady Memorial Hospital Active, not recruiting
Delaware, Ohio, United States, 43015
Oncology Hematology Care Inc-Healthplex Active, not recruiting
Fairfield, Ohio, United States, 45014
Blanchard Valley Hospital Active, not recruiting
Findlay, Ohio, United States, 45840
Atrium Medical Center-Middletown Regional Hospital Active, not recruiting
Franklin, Ohio, United States, 45005-1066
Wayne Hospital Active, not recruiting
Greenville, Ohio, United States, 45331
Kettering Medical Center Active, not recruiting
Kettering, Ohio, United States, 45429
Lancaster Radiation Oncology Terminated
Lancaster, Ohio, United States, 43130
Fairfield Medical Center Active, not recruiting
Lancaster, Ohio, United States, 43130
Lima Memorial Hospital Terminated
Lima, Ohio, United States, 45804
Marietta Memorial Hospital Active, not recruiting
Marietta, Ohio, United States, 45750
Toledo Clinic Cancer Centers-Maumee Active, not recruiting
Maumee, Ohio, United States, 43537
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Active, not recruiting
Maumee, Ohio, United States, 43537
Knox Community Hospital Active, not recruiting
Mount Vernon, Ohio, United States, 43050
Licking Memorial Hospital Active, not recruiting
Newark, Ohio, United States, 43055
Newark Radiation Oncology Active, not recruiting
Newark, Ohio, United States, 43055
Saint Charles Hospital Active, not recruiting
Oregon, Ohio, United States, 43616
Toledo Clinic Cancer Centers-Oregon Terminated
Oregon, Ohio, United States, 43616
Southern Ohio Medical Center Active, not recruiting
Portsmouth, Ohio, United States, 45662
Springfield Regional Medical Center Active, not recruiting
Springfield, Ohio, United States, 45505
Flower Hospital Active, not recruiting
Sylvania, Ohio, United States, 43560
Mercy Hospital of Tiffin Terminated
Tiffin, Ohio, United States, 44883
Toledo Community Hospital Oncology Program CCOP Terminated
Toledo, Ohio, United States, 43617
Mercy Saint Anne Hospital Active, not recruiting
Toledo, Ohio, United States, 43623
Toledo Clinic Cancer Centers-Toledo Active, not recruiting
Toledo, Ohio, United States, 43623
Saint Vincent Mercy Medical Center Terminated
Toledo, Ohio, United States, 43608
University of Toledo Recruiting
Toledo, Ohio, United States, 43614
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Upper Valley Medical Center Active, not recruiting
Troy, Ohio, United States, 45373
Fulton County Health Center Terminated
Wauseon, Ohio, United States, 43567
Saint Ann's Hospital Active, not recruiting
Westerville, Ohio, United States, 43081
Genesis HealthCare System Active, not recruiting
Zanesville, Ohio, United States, 43701
United States, Oklahoma
Cancer Centers of Southwest Oklahoma Research Recruiting
Lawton, Oklahoma, United States, 73505
Contact: Nadim F. Nimeh    877-231-4440      
Principal Investigator: Nadim F. Nimeh         
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Carla Kurkjian    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Carla Kurkjian         
Tulsa Cancer Institute Recruiting
Tulsa, Oklahoma, United States, 74146
Contact: Carla Kurkjian    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Carla Kurkjian         
United States, Oregon
Clackamas Radiation Oncology Center Active, not recruiting
Clackamas, Oregon, United States, 97015
Providence Milwaukie Hospital Terminated
Milwaukie, Oregon, United States, 97222
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Saint Vincent Medical Center Active, not recruiting
Portland, Oregon, United States, 97225
Western Oncology Research Consortium Terminated
Portland, Oregon, United States, 97213
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
United States, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Darius C. Desai    610-954-3582    infolink@slhn.org   
Principal Investigator: Darius C. Desai         
Geisinger Medical Center Active, not recruiting
Danville, Pennsylvania, United States, 17822
Geisinger Medical Center-Cancer Center Hazleton Active, not recruiting
Hazleton, Pennsylvania, United States, 18201
Guthrie Medical Group PC-Robert Packer Hospital Active, not recruiting
Sayre, Pennsylvania, United States, 18840
Geisinger Medical Group Active, not recruiting
State College, Pennsylvania, United States, 16801
Geisinger Wyoming Valley Active, not recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
United States, South Carolina
McLeod Regional Medical Center Active, not recruiting
Florence, South Carolina, United States, 29506
Greenville Memorial Hospital Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Butternut Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Greer Active, not recruiting
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
United States, South Dakota
Rapid City Regional Hospital Active, not recruiting
Rapid City, South Dakota, United States, 57701
United States, Texas
Methodist Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Alexandria T. Phan    713-790-2700      
Principal Investigator: Alexandria T. Phan         
United States, Utah
Huntsman Intermountain Cancer Center-American Fork Hospital Active, not recruiting
American Fork, Utah, United States, 84003
Sandra L Maxwell Cancer Center Active, not recruiting
Cedar City, Utah, United States, 84720
Logan Regional Hospital Active, not recruiting
Logan, Utah, United States, 84321
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84157
Contact: Mark J. Ott    801-507-3950      
Principal Investigator: Mark J. Ott         
McKay-Dee Hospital Center Active, not recruiting
Ogden, Utah, United States, 84403
Utah Valley Regional Medical Center Active, not recruiting
Provo, Utah, United States, 84604-3337
Dixie Medical Center Regional Cancer Center Active, not recruiting
Saint George, Utah, United States, 84770
LDS Hospital Active, not recruiting
Salt Lake City, Utah, United States, 84143
Utah Cancer Specialists-Salt Lake City Active, not recruiting
Salt Lake City, Utah, United States, 84106
United States, Virginia
Fredericksburg Oncology Inc Terminated
Fredericksburg, Virginia, United States, 22401
United States, Washington
Compass Oncology Vancouver Active, not recruiting
Vancouver, Washington, United States, 98684
PeaceHealth Southwest Medical Center Active, not recruiting
Vancouver, Washington, United States, 98664
United States, West Virginia
Edwards Comprehensive Cancer Center Active, not recruiting
Huntington, West Virginia, United States, 25701
United States, Wisconsin
Marshfield Clinic-Chippewa Center Active, not recruiting
Chippewa Falls, Wisconsin, United States, 54729
Marshfield Clinic Cancer Center at Sacred Heart Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Sacred Heart Hospital Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Noelle K. LoConte    877-405-6866      
Principal Investigator: Noelle K. LoConte         
Holy Family Memorial Hospital Recruiting
Manitowoc, Wisconsin, United States, 54221
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Joseph's Hospital Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Marshfield Clinic Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: James P. Thomas    414-805-4380    osu@emergingmed.com   
Principal Investigator: James P. Thomas         
Marshfield Clinic-Minocqua Center Active, not recruiting
Minocqua, Wisconsin, United States, 54548
Cancer Center of Western Wisconsin Active, not recruiting
New Richmond, Wisconsin, United States, 54017
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Mary's Hospital Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic at James Beck Cancer Center Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic-Rice Lake Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Saint Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Marshfield Clinic Cancer Care at Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Marshfield Clinic-Wausau Center Active, not recruiting
Wausau, Wisconsin, United States, 54401
Marshfield Clinic - Weston Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Saint Clare's Hospital Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Wisconsin Rapids Center Active, not recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
United States, Wyoming
Rocky Mountain Oncology Terminated
Casper, Wyoming, United States, 82609
Welch Cancer Center Active, not recruiting
Sheridan, Wyoming, United States, 82801
Canada, Alberta
Tom Baker Cancer Centre Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Cynthia M. Card    403-521-3433      
Principal Investigator: Cynthia M. Card         
Canada, British Columbia
BCCA-Vancouver Cancer Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Hagen F. Kennecke    888-939-3333      
Principal Investigator: Hagen F. Kennecke         
Canada, New Brunswick
The Vitalite Health Network - Dr Leon Richard Oncology Centre Recruiting
Moncton, New Brunswick, Canada, E1C 8X3
Contact: Nicholas G. Finn    506-862-4005      
Principal Investigator: Nicholas G. Finn         
Canada, Nova Scotia
QEII Health Sciences Centre/Capital District Health Authority Recruiting
Halifax, Nova Scotia, Canada, B3H 1V8
Contact: Daniel Rayson    902-473-6000      
Principal Investigator: Daniel Rayson         
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Brandon M. Meyers    905-387-9495      
Principal Investigator: Brandon M. Meyers         
Ottawa Health Research Institute-General Division Recruiting
Ottawa, Ontario, Canada, K1H 1C4
Contact: Timothy R. Asmis    613-761-4395    info@ohri.ca   
Principal Investigator: Timothy R. Asmis         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Monika K. Krzyzanowska    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Monika K. Krzyzanowska         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Haji I. Chalchal    306-766-2213      
Principal Investigator: Haji I. Chalchal         
Sponsors and Collaborators
Investigators
Principal Investigator: Emily Bergsland Alliance for Clinical Trials in Oncology
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01841736     History of Changes
Other Study ID Numbers: NCI-2013-00831, NCI-2013-00831, ALLIANCE A021202, CALGB-A021202, A021202, A021202, U10CA031946, U10CA180821
Study First Received: April 24, 2013
Last Updated: October 30, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Carcinoid Tumor
Carcinoma
Carcinoma, Medullary
Carcinoma, Merkel Cell
Carcinoma, Neuroendocrine
Gastrointestinal Neoplasms
Malignant Carcinoid Syndrome
Neoplasms
Skin Neoplasms
Thyroid Neoplasms
Adenocarcinoma
Digestive System Diseases
Digestive System Neoplasms
DNA Virus Infections
Endocrine Gland Neoplasms
Endocrine System Diseases
Gastrointestinal Diseases
Head and Neck Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Ductal, Lobular, and Medullary
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neuroectodermal Tumors
Neuroendocrine Tumors
Polyomavirus Infections
Skin Diseases
Thyroid Diseases
Tumor Virus Infections

ClinicalTrials.gov processed this record on October 30, 2014