S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer

This study is currently recruiting participants.
Verified February 2014 by Southwest Oncology Group
Sponsor:
Collaborators:
Millennium Pharmaceuticals, Inc.
Information provided by (Responsible Party):
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT01809691
First received: March 8, 2013
Last updated: February 21, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to compare overall survival in newly diagnosed metastatic prostate cancer patients randomly assigned to androgen deprivation therapy (ADT) + TAK-700 versus ADT + bicalutamide.


Condition Intervention Phase
Prostate Cancer
Drug: TAK-700
Drug: Bicalutamide
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer

Resource links provided by NLM:


Further study details as provided by Southwest Oncology Group:

Primary Outcome Measures:
  • Overall survival [ Time Frame: 3.2 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 1486
Study Start Date: March 2013
Estimated Primary Completion Date: July 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ADT + TAK-700

LHRH agonist - given as approved for androgen deprivation at a dose necessary to maintain castrate levels and equivalent to 22.5 mg of Leuprolide IM every 3 months.

TAK-700, 300 mg, PO, twice daily

Drug: TAK-700
300 mg, PO, twice daily
Other Name: Orteronel
Active Comparator: ADT + Bicalutamide

LHRH agonist - given as approved for androgen deprivation at a dose necessary to maintain castrate levels and equivalent to 22.5 mg of Leuprolide IM every 3 months.

Bicalutamide, 50 mg, PO, q daily

Drug: Bicalutamide
50 mg, PO, q daily
Other Name: Casodex

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of metastatic prostate cancer.
  • Serum testosterone within institutional limits of normal.
  • PSA ≥ 2 ng/mL within 90 days prior to initiation of androgen deprivation. therapy (for early induction) or prior to registration (for late induction).
  • DEXA scan within 2 years prior to registration.
  • ECG within 42 days prior to registration and QTc interval ≤ 460 msec.
  • LVEF within 42 days prior to registration and within institutional limits of normal.
  • Adequate hepatic function as evidenced by bilirubin ≤ 2 x institutional upper limit of normal (ULN), SGOT (AST) and SGPT (ALT) ≤ 3 x institutional ULN, or ≤ 5 x institutional ULN if liver metastases are present.
  • Adequate renal function as evidenced by calculated creatinine clearance ≥ 40 mL/min.
  • Adequate hematologic function as evidenced by leukocytes ≥ 3,000/mcL, absolute neutrophil count (ANC) ≥ 1,500/mcL, hemoglobin ≥ 9 g/dL, and platelets ≥ 100,000/mcL.
  • Zubrod performance status of 0 - 2. Zubrod performance status 3 will be allowed if from bone pain only.
  • ≥ 18 years of age.
  • Men of reproduction potential and those who are surgically sterilized (i.e., postvasectomy) must agree to practice effective barrier contraception or agree to abstain from intercourse while receiving treatment on this study and for at least 4 months after protocol treatment ends.

Exclusion Criteria:

  • Known brain metastases.
  • No more than 36 months of prior neoadjuvant and/or adjuvant hormonal therapy.
  • ≥ 6 months since completion of androgen deprivation therapy.
  • Prior or concurrent therapy with ketoconazole, aminoglutethimide or abiraterone acetate, or enzalutamide (MDV3100). Concurrent megestrol for hot flashes is allowed.
  • Prior chemotherapy for treatment of metastatic prostate cancer. Prior chemotherapy in the neoadjuvant or adjuvant setting is allowed.
  • ≥ 2 years since completion of chemotherapy in the neoadjuvant or adjuvant setting.
  • Concurrent use of experimental therapy is not allowed.
  • ≥ 30 days since prior medical castration for metastatic prostate cancer.
  • If method of castration is a LHRH agonist, the patient must be willing to continue the use of LHRH and add bicalutamide or TAK-700 during protocol treatment.
  • If the patient was on an antiandrogen (e.g. bicalutamide, flutamide), the patient must be willing to switch over to bicalutamide or TAK-700 (according to randomization).
  • Prior bilateral orchiectomy.
  • Concurrent use of LHRH antagonists (e.g. Degarelix)
  • Grade III/IV cardiac disease (as defined by the NYHA Criteria), thromboembolic event, unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia.
  • Uncontrolled hypertension (defined as blood pressure > 160 mmHg systolic and > 90 mmHg diastolic at 2 separate measurements no more than 60 minutes apart during the Screening visit) despite appropriate medical therapy.
  • Known human immunodeficiency virus (HIV)infection, active chronic hepatitis B or C, life-threatening illness unrelated to cancer, or any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with participation in this study.
  • History of primary and secondary adrenal insufficiency.
  • Hypersensitivity to TAK-700, to TAK-700 metabolites, to bicalutamide, or to LHRH agonists.
  • Gastrointestinal (GI) disease or GI procedure that could interfere with the GI absorption or tolerance of TAK-700, including difficulty swallowing oral medications.
  • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01809691

Contacts
Contact: Gilbert R. Carrizales, M.S. 614-8808 ext 1027 gcarrizales@swog.org
Contact: Dana B. Sparks, M.A.T. 614-8808 ext 1004 dsparks@swog.org

  Hide Study Locations
Locations
United States, Arizona
Arizona Cancer Center at UMC Orange Grove Recruiting
Tucson, Arizona, United States, 85704
Contact: Parminder Singh    520-626-9008      
Principal Investigator: Parminder Singh         
Arizona Cancer Center at University Medical Center North Recruiting
Tucson, Arizona, United States, 85719
Contact: Parminder Singh    520-626-9008      
Principal Investigator: Parminder Singh         
University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724
Contact: Parminder Singh    520-626-9008      
Principal Investigator: Parminder Singh         
United States, Arkansas
Veteran's Administration Medical Center Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Rangaswamy Govindarajan    501-686-8274      
Principal Investigator: Rangaswamy Govindarajan         
United States, California
Kaiser Permanente-Deer Valley Medical Center Recruiting
Antioch, California, United States, 94531
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
City of Hope Recruiting
Duarte, California, United States, 91010
Contact: Przemyslaw W. Twardowski    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Przemyslaw W. Twardowski         
Kaiser Permanente, Fremont Recruiting
Fremont, California, United States, 94538
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Recruiting
Fresno, California, United States, 93720
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente, Hayward Recruiting
Hayward, California, United States, 94545
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
UC San Diego Moores Cancer Center Recruiting
LA Jolla, California, United States, 92093
Contact: Frederick E. Millard    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: Frederick E. Millard         
Loma Linda University Medical Center Recruiting
Loma Linda, California, United States, 92354
Contact: Chien-Shing (. Chen    909-558-3375      
Principal Investigator: Chien-Shing (. Chen         
University of Southern California Recruiting
Los Angeles, California, United States, 90033
Contact: David I. Quinn    323-865-0451      
Principal Investigator: David I. Quinn         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: David I. Quinn    323-865-0451      
Principal Investigator: David I. Quinn         
Fremont - Rideout Cancer Center Recruiting
Marysville, California, United States, 95901
Contact: Primo N. Lara    916-734-3089      
Principal Investigator: Primo N. Lara         
Mather Veteran Affairs Medical Center Recruiting
Mather, California, United States, 95655
Contact: Thomas J. Semrad    916-734-3089      
Principal Investigator: Thomas J. Semrad         
Mercy UC Davis Cancer Center Recruiting
Merced, California, United States, 95340
Contact: Prasad Pillai    916-734-3089      
Principal Investigator: Prasad Pillai         
Kaiser Permanente-Modesto Recruiting
Modesto, California, United States, 95356
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Jorge A. Garcia-Young    209-572-7116      
Principal Investigator: Jorge A. Garcia-Young         
Kaiser Permanente-Oakland Recruiting
Oakland, California, United States, 94611
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
University of California Medical Center At Irvine-Orange Campus Recruiting
Orange, California, United States, 92868
Contact: James E. Ward    877-827-8839    ucstudy@uci.edu   
Principal Investigator: James E. Ward         
Keck Medical Center of USC Recruiting
Pasadena, California, United States, 91105
Contact: David I. Quinn    323-865-0451      
Principal Investigator: David I. Quinn         
Kaiser Permanente-Redwood City Recruiting
Redwood City, California, United States, 94063
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Richmond Recruiting
Richmond, California, United States, 94801
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-South Sacramento Recruiting
Sacramento, California, United States, 95823
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente - Sacramento Recruiting
Sacramento, California, United States, 95825
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
UC Davis Comprehensive Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Primo N. Lara    916-734-3089      
Principal Investigator: Primo N. Lara         
Kaiser Permanente-San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
California Pacific Medical Center Recruiting
San Francisco, California, United States, 94118
Contact: Ari D. Baron    650-696-4487    PazE@sutterhealth.org   
Principal Investigator: Ari D. Baron         
UCSF-Mount Zion Recruiting
San Francisco, California, United States, 94115
Contact: Terence W. Friedlander    877-827-3222      
Principal Investigator: Terence W. Friedlander         
Kaiser Permanente-Santa Teresa-San Jose Recruiting
San Jose, California, United States, 95119
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-San Rafael Recruiting
San Rafael, California, United States, 94903
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Santa Rosa Recruiting
Santa Rosa, California, United States, 95403
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Stockton Recruiting
Stockton, California, United States, 95210
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Tahoe Forest Cancer Center Recruiting
Truckee, California, United States, 96161
Contact: Primo N. Lara    916-734-3089      
Principal Investigator: Primo N. Lara         
Kaiser Permanente Medical Center-Vacaville Recruiting
Vacaville, California, United States, 95688
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Vallejo Recruiting
Vallejo, California, United States, 94589
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Walnut Creek Recruiting
Walnut Creek, California, United States, 94596
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
United States, Connecticut
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Daniel P. Petrylak    203-785-5702      
Principal Investigator: Daniel P. Petrylak         
Eastern Connecticut Hematology and Oncology Associates Recruiting
Norwich, Connecticut, United States, 06360
Contact: Dennis E. Slater    860-886-8362      
Principal Investigator: Dennis E. Slater         
United States, District of Columbia
Lombardi Comprehensive Cancer Center at Georgetown University Recruiting
Washington, District of Columbia, United States, 20057
Contact: Nancy A. Dawson    202-444-0381      
Principal Investigator: Nancy A. Dawson         
Sibley Memorial Hospital Recruiting
Washington, District of Columbia, United States, 20016
Contact: Channing J. Paller    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Channing J. Paller         
Washington Hospital Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: Nancy A. Dawson    202-444-0381      
Principal Investigator: Nancy A. Dawson         
United States, Florida
Broward Health Medical Center Recruiting
Fort Lauderdale, Florida, United States, 33316
Contact: Archana Maini    954-355-5346      
Principal Investigator: Archana Maini         
Lakeland Regional Cancer Center Recruiting
Lakeland, Florida, United States, 33805
Contact: Gameel B. Hodge    863-904-1900      
Principal Investigator: Gameel B. Hodge         
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Lee M. Zehngebot    407-303-5623      
Principal Investigator: Lee M. Zehngebot         
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Daniel Landau    321-841-7246      
Principal Investigator: Daniel Landau         
H. Lee Moffitt Cancer Center and Research Institute Recruiting
Tampa, Florida, United States, 33612
Contact: Shilpa Gupta    800-456-7121    canceranswers@moffitt.org   
Principal Investigator: Shilpa Gupta         
United States, Georgia
John B Amos Cancer Center Recruiting
Columbus, Georgia, United States, 31904
Contact: Andrew W. Pippas    706-660-6404      
Principal Investigator: Andrew W. Pippas         
Atlanta VA Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Wayne B. Harris    404-778-1868      
Principal Investigator: Wayne B. Harris         
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Charles H. Nash    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Charles H. Nash         
Saint Joseph's-Candler Health System Recruiting
Savannah, Georgia, United States, 31405
Contact: Mark A. Taylor    912-350-8568      
Principal Investigator: Mark A. Taylor         
United States, Hawaii
Oncare Hawaii Inc-Pali Momi Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
OnCare Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817-3169
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Tripler Army Medical Center Recruiting
Honolulu, Hawaii, United States, 96859
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
University of Hawaii Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-POB II Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Kaiser Permanente Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
United States, Idaho
Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
United States, Illinois
Saint Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: David J. Peace    312-355-3046      
Principal Investigator: David J. Peace         
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Walter M. Stadler    773-834-7424      
Principal Investigator: Walter M. Stadler         
Mount Sinai Hospital Medical Center Recruiting
Chicago, Illinois, United States, 60608
Contact: Pam G. Khosla    773-257-5960    suhi@sinai.org   
Principal Investigator: Pam G. Khosla         
Saint Joseph Hospital Recruiting
Chicago, Illinois, United States, 60657
Contact: Ira A. Oliff    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Ira A. Oliff         
Weiss Memorial Hospital Recruiting
Chicago, Illinois, United States, 60640
Contact: Vishal K. Bhalani    773-564-5044      
Principal Investigator: Vishal K. Bhalani         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Joliet Oncology-Hematology Associates Limited Recruiting
Joliet, Illinois, United States, 60435
Contact: Kulumani M. Sivarajan    815-730-3098    maureenc@jolietoncology.com   
Principal Investigator: Kulumani M. Sivarajan         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Ellen R. Gaynor    708-226-4357      
Principal Investigator: Ellen R. Gaynor         
Trinity Medical Center Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Illinois CancerCare-Monmouth Recruiting
Monmouth, Illinois, United States, 61462
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Community Cancer Center Foundation Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Ottawa Regional Hospital and Healthcare Center Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Proctor Hospital Recruiting
Peoria, Illinois, United States, 61614
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Daniel A. Vaena    800-237-1225      
Principal Investigator: Daniel A. Vaena         
VA Medical Center - University of Iowa Recruiting
Iowa City, Iowa, United States, 52246
Contact: Daniel A. Vaena    800-237-1225      
Principal Investigator: Daniel A. Vaena         
United States, Kansas
Cancer Center of Kansas - Chanute Recruiting
Chanute, Kansas, United States, 66720
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Fort Scott Recruiting
Fort Scott, Kansas, United States, 66701
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Saint Rose Ambulatory and Surgery Center Recruiting
Great Bend, Kansas, United States, 67530
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Cancer Center of Kansas-Independence Recruiting
Independence, Kansas, United States, 67301
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Cancer Center of Kansas-Kingman Recruiting
Kingman, Kansas, United States, 67068
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Liberal Recruiting
Liberal, Kansas, United States, 67901
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - McPherson Recruiting
McPherson, Kansas, United States, 67460
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Newton Recruiting
Newton, Kansas, United States, 67114
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Parsons Recruiting
Parsons, Kansas, United States, 67357
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Pratt Recruiting
Pratt, Kansas, United States, 67124
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Salina Recruiting
Salina, Kansas, United States, 67401
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Topeka VA Hospital Recruiting
Topeka, Kansas, United States, 66622
Contact: Ace Allen    800-525-1483      
Principal Investigator: Ace Allen         
Saint Francis Hospital and Medical Center - Topeka Recruiting
Topeka, Kansas, United States, 66606
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Cancer Center of Kansas - Wellington Recruiting
Wellington, Kansas, United States, 67152
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Wichita CCOP Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Associates In Womens Health Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Wichita Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Main Office Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
Contact: Dennie V. Jones    859-257-3379      
Principal Investigator: Dennie V. Jones         
United States, Louisiana
Interim LSU Public Hospital Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-568-3410    aconne1@lsuhsc.edu   
Principal Investigator: Robert W. Veith         
Louisiana State University Health Science Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-568-3410    aconne1@lsuhsc.edu   
Principal Investigator: Robert W. Veith         
United States, Maine
Harold Alfond Center for Cancer Care Recruiting
Augusta, Maine, United States, 04330
Contact: Thomas H. Openshaw    207-973-4274      
Principal Investigator: Thomas H. Openshaw         
Eastern Maine Medical Center Recruiting
Bangor, Maine, United States, 04401
Contact: Thomas H. Openshaw    207-973-4274      
Principal Investigator: Thomas H. Openshaw         
Penobscot Bay Medical Center Recruiting
Rockport, Maine, United States, 04856
Contact: Thomas H. Openshaw    207-973-4274      
Principal Investigator: Thomas H. Openshaw         
United States, Maryland
Johns Hopkins University Recruiting
Baltimore, Maryland, United States, 21287
Contact: Channing J. Paller    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Channing J. Paller         
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Gretchen A. Gignac    617-638-8265      
Principal Investigator: Gretchen A. Gignac         
Caritas Saint Elizabeth's Medical Center Recruiting
Brighton, Massachusetts, United States, 02135-2997
Contact: Olga Kozyreva    617-789-2903      
Principal Investigator: Olga Kozyreva         
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Christopher P. Tretter    781-744-8027      
Principal Investigator: Christopher P. Tretter         
Commonwealth Hematology Oncology PC-Quincy Recruiting
Quincy, Massachusetts, United States, 02169
Contact: James R. Everett    781-337-9091      
Principal Investigator: James R. Everett         
Baystate Medical Center Recruiting
Springfield, Massachusetts, United States, 01199
Contact: Leslie M. Howard    413-794-3565    tamara.wrenn@baystatehealth.org   
Principal Investigator: Leslie M. Howard         
United States, Michigan
University of Michigan Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Ajjai S. Alva    800-865-1125    burton@bcm.edu   
Principal Investigator: Ajjai S. Alva         
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Grand Rapids Clinical Oncology Program Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
United States, Minnesota
Sanford Clinic North-Bemidgi Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Essentia Health Duluth Clinic CCOP Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Manish Kohli    507-538-7623      
Principal Investigator: Manish Kohli         
Coborn Cancer Center at Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Metro-Minnesota CCOP Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Barbara S. Craft    601-815-6700      
Principal Investigator: Barbara S. Craft         
United States, Missouri
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
University of Missouri - Ellis Fischel Recruiting
Columbia, Missouri, United States, 65203
Contact: Carl E. Freter    573-882-7440      
Principal Investigator: Carl E. Freter         
Truman Medical Center Recruiting
Kansas City, Missouri, United States, 64108
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Kansas City Veterans Affairs Medical Center Recruiting
Kansas City, Missouri, United States, 64128
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Phelps County Regional Medical Center Active, not recruiting
Rolla, Missouri, United States, 65401
Saint John's Mercy Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63141
Saint Louis Cancer and Breast Institute-South City Active, not recruiting
Saint Louis, Missouri, United States, 63109
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Joel Picus    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Joel Picus         
CoxHealth South Hospital Active, not recruiting
Springfield, Missouri, United States, 65807
United States, Montana
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Ralph J. Hauke    402-354-5144      
Principal Investigator: Ralph J. Hauke         
United States, Nevada
Nevada Cancer Research Foundation CCOP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: Deepa R. Mocherla    775-982-4400      
Principal Investigator: Deepa R. Mocherla         
United States, New Hampshire
New Hampshire Oncology-Hematology PA Recruiting
Concord, New Hampshire, United States, 03301
Contact: Douglas J. Weckstein    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
LRGHealthcare-Lakes Region General Hospital Recruiting
Laconia, New Hampshire, United States, 03246
Contact: Douglas J. Weckstein    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
United States, New Jersey
Veterans Adminstration New Jersey Health Care System Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Basil S. Kasimis    800-475-2336    patricia.goyer@med.va.gov   
Principal Investigator: Basil S. Kasimis         
Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Tina Mayer    732-235-8675      
Principal Investigator: Tina Mayer         
Sparta Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Jean H. Hoffman-Censits    215-955-6084      
Principal Investigator: Jean H. Hoffman-Censits         
United States, New Mexico
University of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Richard C. Lauer    505-272-6972      
Principal Investigator: Richard C. Lauer         
Hematology Oncology Associates Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Richard C. Lauer    505-272-6972      
Principal Investigator: Richard C. Lauer         
New Mexico Cancer Care Associates Recruiting
Santa Fe, New Mexico, United States, 87505
Contact: Richard C. Lauer    505-272-6972      
Principal Investigator: Richard C. Lauer         
United States, New York
Montefiore Medical Center Recruiting
Bronx, New York, United States, 10467-2490
Contact: Benjamin A. Gartrell    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Benjamin A. Gartrell         
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Recruiting
Brooklyn, New York, United States, 11209
Contact: Andrea N. Leaf    800-877-6976      
Principal Investigator: Andrea N. Leaf         
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: Ellis G. Levine    877-275-7724      
Principal Investigator: Ellis G. Levine         
Veterans Affairs Western New York Health Care System-Buffalo Recruiting
Buffalo, New York, United States, 14215
Contact: Lynn M. Steinbrenner    716-862-3191      
Principal Investigator: Lynn M. Steinbrenner         
Hematology Oncology Associates of Central New York PC-East Syracuse Recruiting
East Syracuse, New York, United States, 13057
Contact: Jeffrey J. Kirshner    315-472-7504      
Principal Investigator: Jeffrey J. Kirshner         
Glens Falls Hospital Recruiting
Glens Falls, New York, United States, 12801
Contact: John P. Stoutenburg    518-926-6700      
Principal Investigator: John P. Stoutenburg         
Orange Regional Medical Center Recruiting
Middletown, New York, United States, 10940
Contact: Jeffrey M. Stewart    845-342-7609      
Principal Investigator: Jeffrey M. Stewart         
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Edward P. Gelmann    212-305-8615      
Principal Investigator: Edward P. Gelmann         
Weill Medical College of Cornell University Recruiting
New York, New York, United States, 10065
Contact: Scott T. Tagawa    212-746-1848      
Principal Investigator: Scott T. Tagawa         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
United States, North Carolina
Mission Hospitals Recruiting
Asheville, North Carolina, United States, 28801
Contact: Christopher H. Chay    828-213-4150      
Principal Investigator: Christopher H. Chay         
Carolinas Medical Center Recruiting
Charlotte, North Carolina, United States, 28203
Contact: Earle F. Burgess    704-355-2884      
Principal Investigator: Earle F. Burgess         
Carolinas Medical Center - Northeast Recruiting
Concord, North Carolina, United States, 28025
Contact: Earle F. Burgess    704-355-2884      
Principal Investigator: Earle F. Burgess         
Park Ridge Hospital Breast Health Center Recruiting
Hendersonville, North Carolina, United States, 28792
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Carolinas Medical Center-Union Recruiting
Monroe, North Carolina, United States, 28112
Contact: Earle F. Burgess    704-355-2884      
Principal Investigator: Earle F. Burgess         
Cleveland Regional Medical Center Recruiting
Shelby, North Carolina, United States, 28150
Contact: Earle F. Burgess    704-355-2884      
Principal Investigator: Earle F. Burgess         
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm    704-873-5661      
Principal Investigator: Ruby A. Grimm         
United States, North Dakota
Sanford Bismarck Medical Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Clinic North-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Medical Center-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus CCOP Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: J. P. Monk    866-627-7616    osu@emergingmed.com   
Principal Investigator: J. P. Monk         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Samaritan North Health Center Recruiting
Dayton, Ohio, United States, 45415
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Dayton CCOP Recruiting
Dayton, Ohio, United States, 45420
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Saint Rita's Medical Center Recruiting
Lima, Ohio, United States, 45801
Contact: Henry Gerad    419-226-9617      
Principal Investigator: Henry Gerad         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Wright-Patterson Medical Center Recruiting
Wright-Patterson Afb, Ohio, United States, 45433-5529
Contact: Brandon J. Cutler    937-257-1398      
Principal Investigator: Brandon J. Cutler         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: George B. Selby    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: George B. Selby         
United States, Oregon
Legacy Mount Hood Medical Center Recruiting
Gresham, Oregon, United States, 97030
Contact: Jacqueline Vuky    503-299-6500      
Principal Investigator: Jacqueline Vuky         
Kaiser Permanente Recruiting
Portland, Oregon, United States, 97227
Contact: Nagendra R. Tirumali    503-335-2400      
Principal Investigator: Nagendra R. Tirumali         
Legacy Good Samaritan Hospital and Medical Center Recruiting
Portland, Oregon, United States, 97210
Contact: Jacqueline Vuky    503-299-6500      
Principal Investigator: Jacqueline Vuky         
Legacy Meridian Park Hospital Recruiting
Tualatin, Oregon, United States, 97062
Contact: Jacqueline Vuky    503-299-6500      
Principal Investigator: Jacqueline Vuky         
United States, Pennsylvania
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111-2497
Contact: Yu-Ning Wong    215-728-4790      
Principal Investigator: Yu-Ning Wong         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Jean H. Hoffman-Censits    215-955-6084      
Principal Investigator: Jean H. Hoffman-Censits         
Hematology and Oncology Associates of North East Pennsylvania Recruiting
Scranton, Pennsylvania, United States, 18508
Contact: Jean H. Hoffman-Censits    215-955-6084      
Principal Investigator: Jean H. Hoffman-Censits         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Terrence P. Cescon    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Susquehanna Cancer Center Recruiting
Williamsport, Pennsylvania, United States, 17701
Contact: Warren L. Robinson    800-598-4282      
Principal Investigator: Warren L. Robinson         
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Roper Hospital Recruiting
Charleston, South Carolina, United States, 29401
Contact: James M. Orcutt    843-720-8386    elizabeth.strojny@roperstfrancis.com   
Principal Investigator: James M. Orcutt         
McLeod Regional Medical Center Recruiting
Florence, South Carolina, United States, 29506
Contact: Rajesh Bajaj    843-679-7256      
Principal Investigator: Rajesh Bajaj         
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Saint Francis Hospital Recruiting
Greenville, South Carolina, United States, 29601
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Instutite/Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Cancer Centers of the Carolinas-Greer Medical Oncology Recruiting
Greer, South Carolina, United States, 29650
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Upstate Carolina CCOP Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
United States, South Dakota
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
United States, Tennessee
Erlanger Medical Center Recruiting
Chattanooga, Tennessee, United States, 37403
Contact: Donald H. Chamberlain    423-698-2050      
Principal Investigator: Donald H. Chamberlain         
United States, Texas
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Kevin D. Courtney    214-648-7097      
Principal Investigator: Kevin D. Courtney         
Ben Taub General Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Nicholas Mitsiades    713-798-1354    burton@bcm.edu   
Principal Investigator: Nicholas Mitsiades         
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Nicholas Mitsiades    713-798-1354    burton@bcm.edu   
Principal Investigator: Nicholas Mitsiades         
Veterans Administration Medical Center Recruiting
Houston, Texas, United States, 77030
Contact: Nicholas Mitsiades    713-798-1354    burton@bcm.edu   
Principal Investigator: Nicholas Mitsiades         
Southwest Oncology Group Not yet recruiting
San Antonio, Texas, United States, 78245
Contact: Neeraj Agarwal    901-414-1779    neeraj.agarwal@hci.utah.edu   
Principal Investigator: Neeraj Agarwal         
United States, Utah
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Neeraj Agarwal    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Neeraj Agarwal         
United States, Washington
Swedish Medical Center-First Hill Recruiting
Seattle, Washington, United States, 98122-4307
Contact: Gary E. Goodman    206-386-2323    patra.grevstad@swedish.org   
Principal Investigator: Gary E. Goodman         
Rockwood Clinic Recruiting
Spokane, Washington, United States, 99220
Contact: Gary E. Goodman    206-386-2323    patra.grevstad@swedish.org   
Principal Investigator: Gary E. Goodman         
Northwest CCOP Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Legacy Salmon Creek Hospital Recruiting
Vancouver, Washington, United States, 98686
Contact: Jacqueline Vuky    503-299-6500      
Principal Investigator: Jacqueline Vuky         
United States, Wisconsin
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311-6519
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Mercy Health System Recruiting
Janesville, Wisconsin, United States, 53547
Contact: Emily G. Robinson    800-928-1103      
Principal Investigator: Emily G. Robinson         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
Vince Lombardi Cancer Clinic-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Vince Lombardi Cancer Clinic Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Milwaukee West Recruiting
Wauwatosa, Wisconsin, United States, 53226
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Sponsors and Collaborators
Southwest Oncology Group
Millennium Pharmaceuticals, Inc.
Investigators
Principal Investigator: Neeraj Agarwal, M.D. University of Utah
  More Information

No publications provided

Responsible Party: Southwest Oncology Group
ClinicalTrials.gov Identifier: NCT01809691     History of Changes
Other Study ID Numbers: S1216, U10CA032102, NCI-2012-02876
Study First Received: March 8, 2013
Last Updated: February 21, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Southwest Oncology Group:
Prostate cancer
TAK-700
Bicalutamide
S1216
androgen therapy
Phase III

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Genital Diseases, Male
Prostatic Diseases
Androgens
Bicalutamide
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions
Androgen Antagonists
Hormone Antagonists
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 15, 2014