A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)

This study is currently recruiting participants.
Verified March 2014 by Pfizer
Sponsor:
Information provided by (Responsible Party):
Pfizer
ClinicalTrials.gov Identifier:
NCT01740427
First received: November 26, 2012
Last updated: March 20, 2014
Last verified: March 2014
  Purpose

The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast cancer who have not received prior systemic anti cancer therapies for their advanced/metastatic disease.


Condition Intervention Phase
Breast Neoplasms
Drug: PD-0332991
Drug: Letrozole
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Multicenter, Double-Blind Phase 3 Study Of PD-0332991 (Oral CDK 4/6 Inhibitor) Plus Letrozole Versus Placebo Plus Letrozole For The Treatment Of Postmenopausal Women With ER (+), HER2 (-) Breast Cancer Who Have Not Received Any Prior Systemic Anti Cancer Treatment For Advanced Disease

Resource links provided by NLM:


Further study details as provided by Pfizer:

Primary Outcome Measures:
  • Progression-Free Survival (PFS) [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    Median time from the first dose of study treatment to the first documentation of objective tumor progression or to death due to any cause, whichever occurs first.


Secondary Outcome Measures:
  • Probability of Participant Survival [ Time Frame: From start of study treatment up to 6 years ] [ Designated as safety issue: Yes ]
    Probability of survival 1-year, 2- and 3-years after the first dose of study treatment

  • Overall Survival (OS) [ Time Frame: Baseline to date of death from any cause (up to 6 years) ] [ Designated as safety issue: Yes ]
    Time from date of randomization to date of death due to any cause.

  • Objective Response (OR) [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    OR is defined as a complete response (CR) or partial response (PR) according to RECIST v.1.1. recorded from randomization until disease progression or death due to any cause.

  • Duration of Response (DR) [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    Time in weeks from the first documentation of objective tumor response to objective tumor progression or death due to any cancer.

  • Disease Control (DC) [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    DC is defined as complete response (CR), partial response (PR), or stable disease (SD) =24 weeks according to the RECIST version 1.1 recorded in the time period between randomization and disease progression or death to any cause.

  • QTc interval [ Time Frame: Baseline and Day 14 of Cycle 1 ] [ Designated as safety issue: Yes ]
    Time between the start of the Q wave and the end of the T wave corrected for heart rate.

  • Minimum Observed Plasma Trough Concentration (Cmin) [ Time Frame: Day 14 of cycles 1 and 2 ] [ Designated as safety issue: No ]
    Minimum Observed Plasma Trough Concentration (Cmin)

  • Change From Baseline in Euro Quality of Life (EQ-5D)- Health State Profile Utility at Week X [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    Instrument designed to assess health status in terms of a single index value or utility score.

  • Change From Baseline in Functional Assessment od Cancer therapy -Breast (FACT-B) at Week X [ Time Frame: Baseline up to 2.5 years ] [ Designated as safety issue: No ]
    Instrument designed to assess patient concerns relating to breast cancer

  • Tumor tissue biomarkers [ Time Frame: Baseline, 24 months ] [ Designated as safety issue: No ]
    Tumor tissue biomarkers will be analyzed to investigate possible associations with resistance/sensitivity to treatment with study drugs. Biomarkers that will be analyzed will be selected based on their known relevance to mechanisms involved in cell cycle regulation.


Estimated Enrollment: 450
Study Start Date: February 2013
Estimated Study Completion Date: March 2016
Estimated Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: PD-0332991 + Letrozole
PD-0332991, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment in combination with Letrozole, 2.5mg, orally once daily (continuously).
Drug: PD-0332991
PD-0332991, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment
Drug: Letrozole
Letrozole, 2.5mg, orally once daily (continuously)
Active Comparator: Placebo + Letrozole
Placebo, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment in combination with Letrozole, 2.5mg, orally once daily (continuously).
Drug: Placebo
Placebo, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment
Drug: Letrozole
Letrozole, 2.5mg, orally once daily (continuously)

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adult women with locoregionally recurrent or metastatic disease not amenable to curative therapy.
  • Confirmed diagnosis of ER positive breast cancer
  • No prior systemic anti-cancer therapy for advanced ER+ disease.
  • Postmenopausal women
  • Measurable disease as per Response Evaluation Criterion in Solid Tumors [RECIST] or bone-only disease
  • Eastern Cooperative Oncology Group [ECOG] 0-2
  • Adequate organ and marrow function
  • Patient must agree to provide tumor tissue

Exclusion Criteria:

  • Confirmed diagnosis of HER2 positive disease
  • Patients with advanced, symptomatic, visceral spread that are at risk of life threatening complication in the short term
  • Known uncontrolled or symptomatic CNS metastases
  • Prior (neo)adjuvant treatment with letrozole or anastrozole with DFI = 12-months from completion of treatment.
  • Prior treatment with any CDK 4/6 inhibitor.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01740427

Contacts
Contact: Pfizer CT.gov Call Center 1-800-718-1021

  Hide Study Locations
Locations
United States, California
UCLA Hematology Oncology Recruiting
Alhambra, California, United States, 91801
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
Kaiser Permanente - Anaheim Recruiting
Anaheim, California, United States, 92806
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Kaiser Permanente Baldwin Park Medical Offices Recruiting
Baldwin Park, California, United States, 91706
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Southern California Kaiser Medical Center - Bellflower Medical Offices Recruiting
Bellflower, California, United States, 90706
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Beverly Hills Cancer Center Recruiting
Beverly Hills, California, United States, 90211
Contact: Roxanne Mendez    310-432-8931    rmendez@bhcancercenter.com   
Kaiser Foundation Hospital Recruiting
Fontana, California, United States, 92335
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
St. Jude Heritage Healthcare - Virginia K. Crosson Cancer Center Recruiting
Fullerton, California, United States, 92835
Contact: Gayle Madden-Mathes    714-446-5900    gmadden@mednet.ucla.edu   
Kaiser Permanente Recruiting
Harbor City, California, United States, 90710
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Kaiser Permanente Irvine Medical Offices Recruiting
Irvine, California, United States, 92618
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
UCLA/TRIO US Network Recruiting
Irvine, California, United States, 92604
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Gayle Madden-Mathes    714-446-5900    gmadden@mednet.ucla.edu   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Sherry Hutcherson    310-750-3300    shutcherson@mednet.ucla.edu   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Laci Wilkins    970-298-7125    laci.wilkins@sclhs.net   
Kaiser Permanente Recruiting
Los Angeles, California, United States, 90027
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Erikan I Enyong    805-543-5577    eenyong@ohmacc.com   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Laci Wilkins    970-298-7125    laci.wilkins@sclhs.net   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Alison Fernandez    805-739-3724    alison.fernandez@dignityhealth.org   
Los Angeles Hematology/Oncology Medical Group Recruiting
Los Angeles, California, United States, 90017
Contact: Kim Long    626-204-7893    klong@healthcarepartners.com   
UCLA Hematology Oncology Recruiting
Los Angeles, California, United States, 90095
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Erikan I Enyong    805-543-5577    eenyong@ohmacc.com   
UCLA West Medical Pharmacy, Attn: Steven L. Wong Recruiting
Los Angeles, California, United States, 90095-7349
Contact: Gayle Madden-Mathes    714-446-5900    gmadden@mednet.ucla.edu   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
Kaiser Permanente Hospital Recruiting
Los Angeles, California, United States, 90034
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-7349
Contact: Sherry Hutcherson    310-750-3300    shutcherson@mednet.ucla.edu   
Keck School of Medicine, University of Southern California Not yet recruiting
Los Angeles, California, United States, 90033
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Ronald Reagan UCLA Medical Center Recruiting
Los Angeles, California, United States, 90095
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
UCLA West Medical Pharmacy Recruiting
Los Angeles, California, United States, 90095-1772
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
TRIO-US Central Administration Recruiting
Los Angeles, California, United States, 90095
Contact: Alison Fernandez    805-739-3724    alison.fernandez@dignityhealth.org   
UCLA School of Medicine Recruiting
Los Angeles, California, United States, 90095
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
Westwood Bowyer Clinic Recruiting
Los Angeles, California, United States, 90095
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
Kaiser Permanente Recruiting
Panorama City, California, United States, 91402
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
UCLA/Pasadena HealthCare Recruiting
Pasadena, California, United States, 91105
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
UCLA Hematology Oncology-Porter Ranch Recruiting
Porter Ranch, California, United States, 91326
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
Cancer Care Associates Medical Group, Inc. Recruiting
Redondo Beach, California, United States, 90277
Contact: Sherry Hutcherson    310-750-3300    shutcherson@mednet.ucla.edu   
Kaiser Permanente Riverside Medical Offices Recruiting
Riverside, California, United States, 92505
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Kaiser Permanente Medical Center Recruiting
San Diego, California, United States, 92120
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
University of California, San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Courtney Grosvenor       GrosvenorC@cc.ucsf.edu   
Coastal Integrative Cancer Care Recruiting
San Luis Obispo, California, United States, 93401
Contact: Erikan I Enyong    805-543-5577    eenyong@ohmacc.com   
Kaiser Permanente Recruiting
San Marcos, California, United States, 92069
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
Central Coast Medical Oncology Corporation Recruiting
Santa Maria, California, United States, 93454
Contact: Alison Fernandez    805-739-3724    alison.fernandez@dignityhealth.org   
UCLA Hematology Oncology - Santa Monica Recruiting
Santa Monica, California, United States, 90404
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
UCLA Hematology Oncology Santa Monica Recruiting
Santa Monica, California, United States, 90404
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
UCLA Santa Monica Medical Center and Orthopaedic Hospital Recruiting
Santa Monica, California, United States, 90404
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
UCLA/Santa Clarita Valley Cancer Center Recruiting
Valencia, California, United States, 91355
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
UCLA Cancer Center Recruiting
Westlake Village, California, United States, 91361
Contact: Katherine Orefice    661-255-2054    KOrefice@mednet.ucla.edu   
Kaiser Permanente Woodland Hills Medical Offices Recruiting
Woodland Hills, California, United States, 91365
Contact: Judith Andaya    323-783-3011    Judith.Andaya@kp.org   
United States, Colorado
St. Mary's Hospital Regional Cancer Center Recruiting
Grand Junction, Colorado, United States, 81501
Contact: Laci Wilkins    970-298-7125    laci.wilkins@sclhs.net   
United States, Connecticut
Smilow Cancer Center at Yale New Haven Recruiting
New Haven, Connecticut, United States, 06510
Contact: Rebecca Lilian    203-737-2226    rebecca.lilian@yale.edu   
Yale University School of Medicine Recruiting
New Haven, Connecticut, United States, 06510
Contact: Rebecca Lilian    203-737-2226    rebecca.lilian@yale.edu   
Whittingham Cancer Center @ Norwalk Hospital Recruiting
Norwalk, Connecticut, United States, 06856
Contact: Rita L Ort    203-852-3063    rita.ort@norwalkhealth.org   
United States, District of Columbia
Washington Cancer Institute at MedStar Washington Hospital Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: Nellie Novielle       noviella@georgetown.edu   
Lombardi Comprehensive Cancer Center - Podium A Recruiting
Washington, District of Columbia, United States, 20007-2197
Contact: Nellie Novielle       noviella@georgetown.edu   
United States, Florida
University of Miami Recruiting
Deerfield, Florida, United States, 33442
Contact: Olga M Aguero    305-243-9811    omachado1@med.miami.edu   
Cancer Specialist of North Florida/Fleming Island Recruiting
Fleming Island, Florida, United States, 32003
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
Michael & Dianne Bienes Cancer Center Not yet recruiting
Fort Lauderdale, Florida, United States, 33308
Contact: Eileen Georgi    954-267-7700    Eileen.Georgi@holy-cross.com   
Memorial Cancer Institute/Breast Cancer Center Recruiting
Hollywood, Florida, United States, 33021
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
Memorial Cancer Institute East Recruiting
Hollywood, Florida, United States, 33021
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
Memorial Regional Hospital Recruiting
Hollywood, Florida, United States, 33021
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
Cancer Specialist of North Florida/Baptist Medical Center- South Recruiting
Jacksonville, Florida, United States, 32258
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
Cancer Specialist of North Florida/Baptist Medical Center- downtown Recruiting
Jacksonville, Florida, United States, 32207
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
Cancer Specialist of North Florida- Southside Recruiting
Jacksonville, Florida, United States, 32258
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
Cancer Specialist of North Florida Recruiting
Jacksonville, Florida, United States, 32256
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
Cancer Specialist of North Florida/ St. Vincent's Recruiting
Jacksonville, Florida, United States, 32204
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
University of Miami Hospital and Clinics Recruiting
Miami, Florida, United States, 33136
Contact: Olga M Aguero    305-243-9811    omachado1@med.miami.edu   
Memorial Cancer Institute West Recruiting
Pembroke Pines, Florida, United States, 33028
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
Memorial Cancer Institute Recruiting
Pembroke Pines, Florida, United States, 33028
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
Memorial Hospital WEST Recruiting
Pembroke Pines, Florida, United States, 33028
Contact: Josephine Caampued    954-265-1844    JCaampued@mhs.net   
University of Miami Recruiting
Plantation, Florida, United States, 33324
Contact: Olga M Aguero    305-243-9811    omachado1@med.miami.edu   
Cancer Specialist of North Florida/St. Augustine Recruiting
St. Augustine, Florida, United States, 32086
Contact: Melissa Rammage    904-519-2731    Melissa.Rammage@CSNF.US   
United States, Georgia
Northeast Georgia Cancer Care, LLC Not yet recruiting
Athens, Georgia, United States, 30607
Contact: Jamie M Hodgson    706-353-2990 ext 279    jhodgson@negacancer.com   
Emory University Hospital Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Regina L Mosley    404-778-4824    rmosle3@emory.edu   
Winship Cancer Institute, Emory University School of Medicine Recruiting
Atlanta, Georgia, United States, 30322
Contact: Regina L Mosley    404-778-4824    rmosle3@emory.edu   
Grady Health System Recruiting
Atlanta, Georgia, United States, 30303
Contact: Regina L Mosley    404-778-4824    rmosle3@emory.edu   
Emory University Hospital Recruiting
Atlanta, Georgia, United States, 30322
Contact: Regina L Mosley    404-778-4824    rmosle3@emory.edu   
Emory Clinic Recruiting
Atlanta, Georgia, United States, 30322
Contact: Regina L Mosley    404-778-4824    rmosle3@emory.edu   
Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care Recruiting
Duluth, Georgia, United States, 30096
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care Recruiting
Lawrenceville, Georgia, United States, 30046
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
Gwinnett Hospital System Inc. -d/b/a-The Center for Cancer Care Recruiting
Lawrenceville, Georgia, United States, 30046
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
Northwest Georgia Oncology Centers, PC Recruiting
Marietta, Georgia, United States, 30060
Contact: Mary Gilley    770-281-5131    mgilley@ngoc.com   
Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care Recruiting
Snellville, Georgia, United States, 30078
Contact: Christopher Davis    770-963-8030 ext 2222    cdavis@suburban-hemonc.com   
United States, Idaho
Kootenai Cancer Center Recruiting
Coeur d'Alene, Idaho, United States, 83814
Contact: Robin Gustin    208-666-3800    rgustin@niccresearch.org   
United States, Illinois
Carle Foundation Hospital DBA Carle Cancer Center Not yet recruiting
Danville, Illinois, United States, 61832
Contact: Christine Canfield    217-383-3010    christine.canfield@carle.com   
Carle Foundation Hospital DBA Carle Cancer Center Not yet recruiting
Effingham, Illinois, United States, 62401
Contact: Christine Canfield    217-383-3010    christine.canfield@carle.com   
Carle Foundation Hospital DBA Carle Cancer Center Not yet recruiting
Mattoon, Illinois, United States, 61938
Contact: Christine Canfield    217-383-3010    christine.canfield@carle.com   
Orchard Healthcare Research Inc. Recruiting
Skokie, Illinois, United States, 60076
Contact: Joy Jardinico    847-731-4143    joy.jardinico@ctca-hope.com   
Carle Foundation Hospital DBA Carle Cancer Center Not yet recruiting
Urbana, Illinois, United States, 61801
Contact: Christine Canfield    217-383-3010    christine.canfield@carle.com   
United States, Kentucky
JG Brown Cancer Center Recruiting
Louisville, Kentucky, United States, 40202
Contact: Belma KAntardzic    502-594-5349    bnkant01@louisville.edu   
United States, Maryland
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Recruiting
Baltimore, Maryland, United States, 21237-3998
Contact: Nellie Novielle       noviella@georgetown.edu   
University of Maryland Not yet recruiting
Baltimore, Maryland, United States, 21201
Contact: Jane Lewis    410-328-7609    jlewis@umm.edu   
Walter Reed National Military Medical Center Recruiting
Bethesda, Maryland, United States, 20889-5600
Contact: Joanna Shay    301-400-0056    joanna.l.shay.ctr@health.mil   
United States, Michigan
U of M Internal Medicine Oncology Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Deborah K Anderson    734-763-5437    debcarl@med.umich.edu   
University of Michigan Health System Recruiting
Ann Arbor, Michigan, United States, 48100
Contact: Deborah K Anderson    734-763-5437    debcarl@med.umich.edu   
Sparrow Regional Cancer Center Not yet recruiting
Lansing, Michigan, United States, 48912
Contact: Kierstyn Hibner    517-364-3712    Kierstyn.Hibner@sparrow.org   
United States, Minnesota
Park Nicollet Frauenshuh Cancer Center Recruiting
St. Louis Park, Minnesota, United States, 55426
Contact: Alissa Gavenda    952-993-6705    Alissa.gavenda@parknicollet.com   
United States, Mississippi
The West Clinic Recruiting
Corinth, Mississippi, United States, 38834
Contact: Tiffany Thompson    662-293-7514    tsthompson@westclinic.com   
The West Clinic Recruiting
Southaven, Mississippi, United States, 38671
Contact: Tiffany Thompson    662-293-7514    tsthompson@westclinic.com   
United States, Missouri
Mercy Clinic St. Louis Cancer and Breast Institute Recruiting
Ballwin, Missouri, United States, 63011
Contact: Samia Das    636-256-5294    Samia.Das@Mercy.Net   
Mercy Hospital St. Louis Recruiting
St. Louis, Missouri, United States, 63141
Contact: Samia Das    636-256-5294    Samia.Das@Mercy.Net   
Mercy Clinic St. Louis Cancer and Breast Institute Recruiting
St. Louis, Missouri, United States, 63109
Contact: Samia Das    636-256-5294    Samia.Das@Mercy.Net   
St. John's Mercy, David C. Pratt Cancer Center Recruiting
St. Louis, Missouri, United States, 63141
Contact: Samia Das    636-256-5294    Samia.Das@Mercy.Net   
United States, Nebraska
Saint Francis Cancer Treatment Center Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Courtney Fuller    308-398-6518    cfuller@sfmc-gi.org   
Saint Francis Medical Center Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Courtney Fuller    308-398-6518    cfuller@sfmc-gi.org   
Saint Frances Medical Center Recruiting
Hastings, Nebraska, United States, 68901
Contact: Courtney Fuller    308-398-6518    cfuller@sfmc-gi.org   
United States, Nevada
Comprehensive Cancer Centers of Nevada Recruiting
Henderson, Nevada, United States, 89052
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Comprehensive Cancer Centers of Nevada Recruiting
Henderson, Nevada, United States, 89074
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Comprehensive Cancer Centers of Nevada Research Department Recruiting
Henderson, Nevada, United States, 89052
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89169
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: Sue Yates    702-384-0013    sue.yates@usoncology.com   
United States, New York
Mount Kisco Medical Group Recruiting
Mount Kisco, New York, United States, 10549
Contact: Ahn Phung    914-666-1366    aphung@nwhc.net   
Northern Westchester Hospital Recruiting
Mt Kisco, New York, United States, 10549
Contact: Ahn Phung    914-666-1366    aphung@nwhc.net   
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Man Chi Ngan    212-304-5580    mn2527@cumc.columbia.edu   
Herbert Irving Comprehensive Cancer Center Recruiting
New York, New York, United States, 10032
Contact: Man Chi Ngan    212-304-5580    mn2527@cumc.columbia.edu   
Stony Brook University Medical Center Cancer Center Recruiting
Stony Brook, New York, United States, 11794-8446
Contact: Michele McCauley       michele.mccauley@stonybrookmedicine.edu   
United States, Oregon
Oregon Health and Science University Recruiting
Portland, Oregon, United States, 97201-3098
Contact: Bridget C Gilbert-Ghormley    503-498-9736    boylebr@ohsu.edu   
Northwest Cancer Specialists, P.C. Recruiting
Portland, Oregon, United States, 97227
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
Northwest Cancer Specialists, PC Recruiting
Portland, Oregon, United States, 97213
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
Kaiser Permanente Northwest Region Not yet recruiting
Portland, Oregon, United States, 97227
Contact: Marjorie Erwin    503-331-6294    marjorie.erwin@kpchr.org   
Northwest Cancer Specialists, P.C. Recruiting
Tualatin, Oregon, United States, 97062
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
United States, South Carolina
Medical University of South Carolina Not yet recruiting
Charleston, South Carolina, United States, 29425
Contact: Sarah Daanen         
United States, Tennessee
The West Clinic Recruiting
Memphis, Tennessee, United States, 38120
Contact: Tiffany Thompson    662-293-7514    tsthompson@westclinic.com   
The West Clinic Recruiting
Memphis, Tennessee, United States, 38104
Contact: Tiffany Thompson    662-293-7514    tsthompson@westclinic.com   
The Sarah Cannon Cancer Center Recruiting
Nashville, Tennessee, United States, 37203
Contact: Julie Trundle    615-329-7413    Julie.Trundle@scresearch.net   
United States, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center Recruiting
Dallas, Texas, United States, 75246
Contact: Jonathan Huntzinger    214-370-1942    Jonathan.huntzinger@usoncology.com   
Texas Oncology, PA Recruiting
Dallas, Texas, United States, 75231
Contact: Amy Jordan    214-346-3508    amy.jordan@usoncology.com   
Texas Oncology-El Paso Cancer Treatment Center Grandview Recruiting
El Paso, Texas, United States, 79902
Contact: Naomi Yrigoyen-Ortega    915-544-6750    naomi.yrigoyen@usoncology.com   
Texas Oncology-El Paso Cancer Treatment Center Joe Battle Recruiting
El Paso, Texas, United States, 79939
Contact: Naomi Yrigoyen-Ortega    915-544-6750    naomi.yrigoyen@usoncology.com   
El Paso Cancer Treatment Center Recruiting
El Paso, Texas, United States, 79915
Contact: Naomi Yrigoyen-Ortega    915-544-6750    naomi.yrigoyen@usoncology.com   
Investigational Products Center (IPC) Not yet recruiting
Fort Worth, Texas, United States, 76177
Contact: Christine Canfield    217-383-3010    christine.canfield@carle.com   
Investigational Products Center (IPC) Recruiting
Fort Worth, Texas, United States, 76177
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Investigational Products Center (IPC) Not yet recruiting
Fort Worth, Texas, United States, 76177
Contact: Kristy Lee    972-867-3577    kristy.lee@usoncology.com   
Investigational Products Center (IPC) Recruiting
Fort Worth, Texas, United States, 76177
Contact: Naomi Yrigoyen-Ortega    915-544-6750    naomi.yrigoyen@usoncology.com   
Investigational Products Center (IPC) Recruiting
Fort Worth, Texas, United States, 76177
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
US Oncology Research and Clinical Pharmacy (Drug Shipment Only) Not yet recruiting
Fortworth, Texas, United States, 76177
Contact: Jennifer Stewart    214-778-4127    Jennifer.Stewart2@usoncology.com   
US Oncology Research and Clinical Pharmacy (Drug Shipment Only) Recruiting
Fortworth, Texas, United States, 76177
Contact: Heather Boyd       Heather.boyd@usoncology.com   
US Oncology Research and Clinical Pharmacy (Drug Shipment Only) Recruiting
Fortworth, Texas, United States, 76177
Contact: Jonathan Huntzinger    214-370-1942    Jonathan.huntzinger@usoncology.com   
US Oncology Research and Clinical Pharmacy (Drug Shipment Only) Recruiting
Fortworth, Texas, United States, 76177
Contact: Amy Jordan    214-346-3508    amy.jordan@usoncology.com   
Texas Oncology � Garland Not yet recruiting
Garland, Texas, United States, 75042
Contact: Jennifer Stewart    214-778-4127    Jennifer.Stewart2@usoncology.com   
The University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology Recruiting
Houston, Texas, United States, 77030-4009
Contact: Gil R Guerra    713-792-2860    grguerra@mdanderson.org   
Texas Oncology - Plano West Not yet recruiting
Plano, Texas, United States, 75093
Contact: Jennifer Stewart    214-778-4127    Jennifer.Stewart2@usoncology.com   
Texas Oncology-Plano East Not yet recruiting
Plano, Texas, United States, 75075-7787
Contact: Kristy Lee    972-867-3577    kristy.lee@usoncology.com   
United States, Virginia
Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care Recruiting
Blacksburg, Virginia, United States, 24060
Contact: Joyce Whitfield       joyce.whitfield@usoncology.com   
Virginia Oncology Associates Recruiting
Chesapeake, Virginia, United States, 23320
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Virginia Oncology Associates Recruiting
Hampton, Virginia, United States, 23666
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care Recruiting
Low Moor, Virginia, United States, 24457
Contact: Joyce Whitfield       joyce.whitfield@usoncology.com   
Virginia Oncology Associates Recruiting
Newport News, Virginia, United States, 23606
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Virginia Oncology Associates Recruiting
Norfolk, Virginia, United States, 23502
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care Recruiting
Roanoke, Virginia, United States, 24014
Contact: Joyce Whitfield       joyce.whitfield@usoncology.com   
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care Recruiting
Salem, Virginia, United States, 24153
Contact: Joyce Whitfield       joyce.whitfield@usoncology.com   
Virginia Oncology Associates Recruiting
Virginia Beach, Virginia, United States, 23456
Contact: Tracy J Harding    757-466-8683    tracy.harding@usoncology.com   
Shenandoah Oncology, P.C. Recruiting
Winchester, Virginia, United States, 22601
Contact: Heather Boyd       Heather.boyd@usoncology.com   
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care Recruiting
Wytheville, Virginia, United States, 24382
Contact: Joyce Whitfield       joyce.whitfield@usoncology.com   
United States, Washington
Evergreen Hospital Medical Center Recruiting
Kirkland, Washington, United States, 98034
Contact: Melissa Griffin    206-288-7051    griffmj@u.washington.edu   
Seattle Cancer Care Alliance at Evergreen Health Recruiting
Kirkland, Washington, United States, 98034
Contact: Melissa Griffin    206-288-7051    griffmj@u.washington.edu   
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
Contact: Melissa Griffin    206-288-7051    griffmj@u.washington.edu   
Northwest Cancer Specialists P.C. Recruiting
Vancouver, Washington, United States, 98684
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
Northwest Cancer Specialists, P.C. Recruiting
Vancouver, Washington, United States, 98683
Contact: Margaret E Bigler    503-231-2612    margaret.bigler@usoncology.com   
United States, West Virginia
West Virginia University - Department of Medicine Recruiting
Morgantown, West Virginia, United States, 26506-9162
Contact: Patricia Beal    304-293-0609    pbeal@hsc.wvu.edu   
United States, Wisconsin
UW Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792
Contact: Tamara M Koehn       tmkoehn@medicine.wisc.edu   
Australia, New South Wales
North Coast Cancer Institute/Port Macquarie Base Hospital Recruiting
Port Macquarie, New South Wales, Australia, 2444
Contact: Nyomie Johnson         
Calvary Mater Newcastle Recruiting
Waratah, New South Wales, Australia, 2310
Contact: Sue Brew    +61 (02) 4921-1459    sue.brew@calvarymater.org.au   
Australia, Queensland
Icon Cancer Care Wesley Recruiting
Auchenflower, Queensland, Australia, 4066
Contact: Liana Fernandez    +61737374558    lfernandez@hoca.com.au   
Nambour General Hospital Recruiting
Nambour, Queensland, Australia, 4560
Contact: Ann Kennedy    +61 (07) 5470-5655    Ann_Kennedy@health.qld.gov.au   
Princess Alexandra Hospital Recruiting
Wooloongabba, Queensland, Australia, 4102
Contact: Jennifer M Suffolk    07 317 67825    JenniferM.Suffolk@health.qld.gov.au   
Australia, South Australia
Royal Adelaide Hospital, Department of Medical Oncology Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Pushparaj Velayudham       Pushparaj.Velayudham@health.sa.gov.au   
Australia, Victoria
Day Oncology, Northern Hospital Not yet recruiting
Epping, Victoria, Australia, 3076
Contact: Anastasia Hutchinson    +61 (03) 8405-8480    anastasia.hutchinson@nh.org.au   
Royal Melbourne Hospital Recruiting
Parkville, Victoria, Australia, 3050
Contact: Edwin Young    +61 3 9342 8673    edwin.young@mh.org.au   
Epworth Hospital Not yet recruiting
Richmond, Victoria, Australia, 3121
Contact: Felicity Osmond    +61 (03) 9936-8055    felicity.osmond@epworth.org.au   
Maroondah Hospital Recruiting
Ringwood East, Victoria, Australia, 3135
Contact: Amy Tang       amy.tang@easternhealth.org.au   
Australia
Bendigo Hospital Recruiting
Bendigo, Australia, VIC 3550
Contact: Janet Holland    +61 (03) 5454-8821    JHolland@bendigohealth.org.au   
Kinghorn Cancer Centre / St Vincent�s Hospital (Sydney) Pty Ltd Recruiting
Darlinghurst, Australia, 2010
Contact: Lynne Jolly    +61 (02) 9355-5617    ljolly@stvincents.com.au   
Royal Perth Hospital, Department of Medical Oncology Recruiting
Perth, Australia, 6000
Contact: Caroline Stone    +61 8 9224 1317    caroline.stone@health.wa.gov.au   
Goulburn Valley Health Recruiting
Shepparton, Australia, 3630
Contact: Vicki Clowes    +61 3 58323778    vicki.clowes@gvhealth.org.au   
Belgium
UZ Brussel Recruiting
Brussel, Belgium, 1090
Contact: Alex Dewaele    32-2-4775459    alex.dewaele@uzbrussel.be   
Oncologie Recruiting
Brussels, Belgium, 1200
Contact: Vanessa QUIBUS       vanessa.quibus@uclouvain.be   
Institut Jules Bordet Recruiting
Brussels, Belgium, 1000
Contact: Berline Tako Mouafo    +32 2 541 3142    berline.takomouafo@bordet.be   
Grand Hopital de Charleroi / Service d'Hematologie et Oncologie Recruiting
Charleroi, Belgium, 6000
Contact: Stephanie Adam    +3271104762    stephanie.adam@ghdc.be   
Universitair Ziekenhuis Leuven - Campus Gasthuisberg Recruiting
Leuven, Belgium, 3000
Contact: Leen Trappeniers       leen.trappeniers@uzleuven.be   
CHU de Liege Recruiting
Liege 1, Belgium, 4000
Contact: Maude Piron    +32 4 366 71 11 bip 4454    mpiron@chu.ulg.ac.be   
Centre Hospitalier Peltzer - La Tourelle, Service de Cancerologie Not yet recruiting
Verviers, Belgium, 4800
Contact: Val�rie Graindorge    32-84-212319    valerie.graindorge@chplt.be   
GZA ziekenhuizen Campus, Sint-Augustinusziekenhuis Recruiting
Wilrijk, Belgium, 2610
Contact: Jan Van der Eycken    +32 3 443 37 59    cto@gza.be   
Canada, Alberta
Tom Baker Cancer Centre Not yet recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Sherry Qian    403-521-3492    sherry.qian@albertahealthservices.ca   
Cross Cancer Institute Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Melody Augier    780-432-8695    Melody.Augier@albertahealthservices.ca   
Canada, British Columbia
BC Cancer Agency-Fraser Valley Centre Recruiting
Surrey, British Columbia, Canada, V3V 1Z2
Contact: Monica Fourt    604-930-4064    mfourt@bccancer.bc.ca   
British Columbia Cancer Agency-Vancouver Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Shifania Premji    16048776098    SPremji@bccancer.bc.ca   
Canada, Nova Scotia
QEII Health Sciences Centre, Nova Scotia Cancer Centre Active, not recruiting
Halifax, Nova Scotia, Canada, B3H 1V7
QEII Health Sciences Centre, Victoria General Site Active, not recruiting
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
London Regional Cancer Program Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Lorraine Hewett    519-685-8618    Lorraine.Hewett@lhsc.on.ca   
Southlake Regional Health Centre / Stronach Regional Cancer Centre Recruiting
Newmarket, Ontario, Canada, L3Y2P9
Contact: Shelina Sabur    905-895-4521 ext. 2297    SSabur@southlakeregional.org   
Northeast Cancer Centre of Health Sciences North Not yet recruiting
Sudbury, Ontario, Canada, P3E 5J1
Contact: Mark Whissell    705-522-6237 x 2402    mawhissell@hrsrh.on.ca   
Princess Margaret Hospital - University Health Network Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Albert Cho    416-946-4501 x2414    albert.cho@uhn.ca   
Sunnybrook Research Institute Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: Jeffrey Pham    416) 480-5000 ext. 1055    Jeff.Pham@sunnybrook.ca   
St. Michaels Hospital Recruiting
Toronto, Ontario, Canada, M5B 1W8
Contact: Antonio Estacio    416-864-6060 x 3838    EstacioA@smh.ca   
Canada, Quebec
Hopital du Sacre-Coeur Recruiting
Montreal, Quebec, Canada, H4JIC5
Contact: Marie-Anne Capobianco    514-338-2222 x3493    marie-anne.capobianco@crhsc.rtss.qc.ca   
Jewish General Hospital Recruiting
Montreal, Quebec, Canada, H3T 1E2
Contact: Ioana Eniu    514-340-8222ext. 4596    ieniu@jgh.mcgill.ca   
Royal Victoria Hospital Recruiting
Montreal, Quebec, Canada, H3A 1A1
Contact: Ioana Eniu    514-340-8222ext. 4596    ieniu@jgh.mcgill.ca   
St. Mary's Hospital Recruiting
Montreal, Quebec, Canada, H3T 1M5
Contact: Ioana Eniu    514-340-8222ext. 4596    ieniu@jgh.mcgill.ca   
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Bernadette Procyk    306-766-2464    bernadette.procyk@saskcancer.ca   
Canada
Center Hospitalier Affilie Universitaire de Quebec, Hopital du Saint Sacrement Recruiting
Quebec, Canada, G1S 4L8
Contact: Nathalie Carmichael    418-682-7511 x4551    nathalie.carmichael.cha@ssss.gouv.qc.ca   
Czech Republic
Compr Cancer Ctr of University Hospital Hradec Kralove Not yet recruiting
Hradec Kralove, Czech Republic, 500 05
Contact: Simona Sediva    +420 495832489    simona.sediva@fnhk.cz   
Fakultni nemocnice Olomouc Not yet recruiting
Olomouc, Czech Republic, 775 20
Contact: Monika Steckerova    011420588442522    monika.steckerova@fnol.cz   
France
Institut de Cancerologie de I�Ouest-Paul Papin Not yet recruiting
Angers Cedex 9, France, 49933
Contact: Pierre Celea    +33 2 41 35 27 00    Pierre.Celea@ico.unicancer.fr   
Centre Fran�ois Baclesse Recruiting
Caen Cedex 5, France, 14076
Contact: Sara Grossi    +33 2 31 45 51 87    s.grossi@baclesse.fr   
Centre Georges Fran�ois Leclerc Recruiting
Dijon Cedex, France, 21079
Contact: Dounia KARMOUS    0033380737756    DKarmous@cgfl.fr   
Centre hospitalier Departemental les Oudairies Recruiting
La Roche-Sur-Yon, France, 85025
Contact: Isabelle Lepage    +33251446161    isabelle.lepage@chd-vendee.fr   
Centre Oscar Lambret Not yet recruiting
Lille, France, 59020
Contact: nathalie devienne    03.20.29.59.35    n-devienne@o-lambret.fr   
Centre Val d'Aurelle, Not yet recruiting
Montpellier CEDEX 5, France, 34298
Contact: Christine Gestin Boyer    33-4-67-61-25-15    Christine.Gestin-Boyer@icm.unicancer.fr   
Centre Antoine Lacassagne Recruiting
Nice cedex 2, France, 06189
Contact: Beatrice De Clercq    +334 92 03 16 62    beatrice.declercq@nice.unicancer.fr   
Institut Curie, D�partement d'Oncologie M�dicale Recruiting
Paris Cedex 05, France, 75248
Contact: Daisylia Delanoe    +33 (0) 1.56.24.56.39    daisylia.delanoe@curie.fr   
Institut Jean Godinot Not yet recruiting
Reims, France, 51056
Contact: Sandrine Meunier    + 33 3 26 50 44 85    Sandrine.MEUNIER@reims.unicancer.fr   
Centre Eugene Marquis Recruiting
Rennes, France, 35062
Contact: Manuel Croix    +33 2 99 25 29 35    m.croix@rennes.unicancer.fr   
Institut Curie - Hopital Rene Huguenin Recruiting
Saint-Cloud, France, 92210
Contact: Mitra Coulon    01-47-11-23-81 (Poste 30 36)    mitra.coulon@curie.fr   
Centre Rene Gauducheau Not yet recruiting
St Herblain, France, 44805
Contact: Severine Maury    0240679167    Severine.Maury@ico.unicancer.fr   
Institut Claudius Regaud Recruiting
Toulouse, France, 31000
Contact: Marta Dabek    33 (0)5 67 22 27 54    Dabek.Marta@claudiusregaud.fr   
Institut Gustave Roussy Recruiting
Villejuif, France, 94805
Contact: Aranjah Thevarajah    + 33 (0)1 42 11 42 11 (poste 3    Aranjah.THEVARAJAH@igr.fr   
Germany
University of Kiel Not yet recruiting
Kiel, SH, Germany, 24105
Contact: Silke Kassner    0049-431-597 4089    sgo@uksh.de   
Klinikum St. Marien Not yet recruiting
Amberg, Germany, 92224
Contact: Jacqueline Roy    +49-9621-381381    roy.jacqueline@klinikum-amberg.de   
Klinikverbund Sudwest - Kliniken Sidelfingen-Boblingen Recruiting
Boeblingen, Germany, 71032
Contact: Silke Biermann    +49703166829114    S.Biermann@klinikverbund-suedwest.de   
Universitaetsklinikum Dresden Recruiting
Dresden, Germany, 01307
Contact: Christine Leffler    0049-351-458 3508    Christine.Leffler@uniklinikum-dresden.de   
Universitaetsklinikum Erlangen, Klinik fuer Frauenheilkunde Recruiting
Erlangen, Germany, 91054
Contact: Saskia Langner    +49-9131-8536167    saskia.langner@uk-erlangen.de   
Klinik Esslingen - Klinik Fur Frauenheilkunde Und Geburtshilfe Not yet recruiting
Esslingen am Neckar, Germany, 73730
Contact: Angelika Jursik    +49 711 3103 3064    angelikajursik@gmx.de   
Zentrum Fur Frauenheilkunde Und Geburtshilfe Not yet recruiting
Frankfurt, Germany, 60590
Contact: Stefan M Loitsch    +49-69-6301-6850    stefanmarcel.loitsch@kgu.de   
Staedtische Kliniken Frankfurt am Main-Hoechst Frauenklinik Not yet recruiting
Frankfurt am Main, Germany, 65929
Contact: Christina Weissmueller    +496930059945    christina.weissmueller@skfh.de   
Klinikum Fulda gAG Not yet recruiting
Fulda, Germany, 36043
Contact: Kerstin Bellof-Thrams    +49 661 84 5487    kerstin.bellof-thrams@klinikum-fulda.de   
Universitaetsklinikum Hamburg-Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Krenkel Sylke    +49 40 7410 58130    s.krenkel@uke.de   
St. Elisabeth-Kh - Gynakologie Not yet recruiting
Koeln, Germany, 50924
Contact: Sigrun Wolfsturm       Sigrun.Wolfsturm@hohenlind.de   
Universitaetsklinikum Magdeburg A.oe.R. Recruiting
Magdeburg, Germany, 39108
Contact: Christel Besseler    0391/6717438    christel.besseler@med.ovgu.de   
Katholisches Klinikum Mainz Recruiting
Mainz, Germany, 55131
Contact: Ursula Winter    +496131-575 831420    gyn-onk@kkmainz.de   
Klinikum Grosshadern Recruiting
Muenchen, Germany, 81337
Contact: Gabriele Breu    +49 89 5160-4317    gabriele.breu@med.uni-muenchen.de   
Rotkreuzklinikum Munchen Gmbh Recruiting
Muenchen, Germany, 80637
Contact: Harry Reisch    +49-89-15706-661    harry.reisch@swmbrk.de   
Frauenklinik und Poliklinik Klinikum rechts der Isar, Technische Universitaet Muenchen Recruiting
Muenchen, Germany, 81675
Contact: Rita Rosenkranz    +498941406629    rita.rosenkranz@mri.tum.de   
Onkologische Praxis Muenchen Recruiting
Muenchen, Germany, 80336
Contact: Simone Schiersner    +49 89-599888830    S.Schiersner@ioz-muenchen.de   
Universit�tsfrauenklinik und Poliklinik am Klinikum S�dstadt Rostock Not yet recruiting
Rostock, Germany, 18059
Contact: Beatrice Engel    0049 381 4401-6143    beatrice.engel@kliniksued-rostock.de   
Mutterhaus der Borromaeerinnen, Innere Medizin I Recruiting
Trier, Germany, 54290
Contact: Thomas Marchand    0049-651-947 2571    thomas.marchand@mutterhaus.de   
Hungary
Szent Margit Korhaz Onkologia Recruiting
Budapest, Hungary, 1032
Contact: Zsuzsanna Toth    +3612502420 ext. 1270    zsuzsanna.toth@coordination.hu   
Orsz�gos Onkol�giai Int�zet Recruiting
Budapest, Hungary, 1122
Contact: Lilla Varkonyi    +3612248600 ext. 3514    lilla.varkonyi@coordination.hu   
Semmelweis Egyetem �ltal�nos Orvostudom�nyi Kar Not yet recruiting
Budapest, Hungary, 1083
Contact: Andrea Makra    +36206663185    trial.sote@gmail.com   
Petz Aladar Megyei Oktato Korhaz Recruiting
Gyor, Hungary, 9024
Contact: Marta Janoki    +36 70 451-05-68    janoki.m@gmail.com   
Petz Aladar Megyei Oktato Korhaz, Onkoradiologia Recruiting
Gyor, Hungary, 9024
Contact: Marta Janoki    +36 70 451-05-68    janoki.m@gmail.com   
Josa Andras Hospital Recruiting
Nyiregyhaza, Hungary, 4400
Contact: Angela Litvai    +3642599700 ext. 1895    litvai.angela@szszbmk.hu   
Szegedi Egyetem Onkologiai Klinika Recruiting
Szeged, Hungary, 6720
Contact: Iren Tanczos    36-62-544943    tanczika70@freemail.hu   
Ireland
Bon Secours Hospital Recruiting
Cork, Ireland
Contact: Sarah Thompson    +353 (0) 21 454 2807 ext 2663 P    sthompson@bonsecours.ie   
St. James Hospital Recruiting
Dublin, Ireland, 8
Contact: Ingrid Kiernan    +353 1 4103754    ikiernan@stjames.ie   
Beaumont Hospital Recruiting
Dublin, Ireland, 9
Contact: Derval Kehily    +353 (0)1 8092010    dervalkehily@beaumont.ie   
Mater Misericordiae University Hospital Recruiting
Dublin, Ireland, Dublin 7
Contact: Martina Smith    +353 (0)1 8034834    msmith@mater.ie   
St Vincents University Hospital Recruiting
Dublin 4, Ireland
Contact: Deirdre McDonnell    00353 1 2214893    deirdre.mcdonnell@ccrt.ie   
Mater Private Hospital Not yet recruiting
Dublin 7, Ireland
Contact: Martina Smith    +353 (0)1 8034834    msmith@mater.ie   
Department of Medical Oncology Recruiting
Galway, Ireland
Contact: Mary Byrne    +353 (0) 91 542954    marymarg.byrne@hse.ie   
Mid Western Regional Hospital Recruiting
Limerick, Ireland
Contact: Melissa Browne    +35361485148    melissa.browne@hse.ie   
Waterford Regional Hospital Recruiting
Waterford, Ireland
Contact: Flordeliza Calacsan    00353 51 848590    Flordeliza.Calacsan@hse.ie   
Italy
Divisione Oncologia Medica Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST Recruiting
Meldola, FC, Italy, 47014
Contact: Daniele Andreis    +39 0543 739264    d.andreis@irst.emr.it   
IRCCS - Istituto Europeo di Oncologia Not yet recruiting
Milano, Milan, Italy, 20141
Contact: Claudia Sangalli    +390257489840    claudia.sangalli@ieo.it   
Azienda Ospedaliera San Giuseppe Moscati Not yet recruiting
Avellino, Italy, 83100
Policlinico Sant'Orsola-Malpighi Not yet recruiting
Bologna, Italy, 40138
Contact: Sara Tomasini    +390516364547    sara.tomasini@aosp.bo.it   
Universita' Degli Studi di Napoli Federico II Not yet recruiting
Napoli, Italy, 80131
Contact: Antonio Pepe    39-081-7463662    studiclinici.oncologia@unina.it   
Azienda Ospedaliero-Universitaria Pisana Not yet recruiting
Pisa, Italy, 56126
Contact: Cinzia Orlandini    39-050-993173    c.orlandini@med.unipi.it   
Istituto Regina Elena - Struttura Complessa Oncologia Medica A Not yet recruiting
Roma, Italy, 00144
Contact: Ilaria Carbone    39-06-52662745    carbone.ilax@yahoo.it   
Ospedale SS Trinita Not yet recruiting
Sora (FR), Italy, 03039
Japan
Aichi Cancer Center Hospital Recruiting
Nagoya, Aichi, Japan
Contact: Kishiko Hibino    01181527626111    jutaku_b@aichi-cc.jp   
National Cancer Center Hospital East Recruiting
Kashiwa, Chiba, Japan
Contact: Kazumi Yamaguchi       kayamagu@east.ncc.go.jp   
National Hospital Organization Hokkaido Cancer Center Recruiting
Sapporo, Hokkaido, Japan
Contact: Shinya Takada    81-11-811-9111    cr12@sap-cc.go.jp   
Saitama Cancer Center Not yet recruiting
Kita-adachi-gun, Saitama, Japan
Contact: Yoko Kinokiri    01181353192723    y-kinokiri@epmint.co.jp   
National Cancer Center Hospital Recruiting
Chuo-Ku, Tokyo, Japan
Contact: Rie Nakano    +81-3-3542-2511    rnakano@ncc.go.jp   
Chiba Cancer Center Recruiting
Chiba, Japan
Contact: Chiyoko Motomura    81-43-264-5431    cmotomura@chiba-cc.jp   
National Hospital Organization Shikoku Cancer Center Recruiting
Ehime, Japan
Contact: Rie Watanabe    +81-89-999-1172    riwatanabe@shikoku-cc.go.jp   
National Hospital Organization Kyushu Cancer Center Recruiting
Fukuoka, Japan
Contact: Kiyo Aramaki    01181925413231    karamaki@nk-cc.go.jp   
Hiroshima City Hospital Recruiting
Hiroshima, Japan
Contact: Miki Ichisawa    81-82-221-5233    m-ichisawa@epmint.co.jp   
Iwate Medical University Hospital Not yet recruiting
Iwate, Japan
Contact: Yukiko Honda    81196515111    yukiko.honda@j.iwate-med.ac.jp   
Hakuaikai Medical Corporation Sagara Hospital Recruiting
Kagoshima, Japan
Contact: Yuka Hidaka    81-99-224-1800    yuka-hidaka@sagara.or.jp   
Kumamoto University Hospital Recruiting
Kumamoto, Japan
Contact: Rumiko Minami    81-96-373-5842    minami-kmm@umin.ac.jp   
Kumamoto Municipal Hospital Recruiting
Kumamoto, Japan
Contact: Yuka Kinoshita       kinoshita@csnt.co.jp   
Niigata Cancer Center Hospital 2-15-3 Recruiting
Niigata, Japan
Contact: Akiko Oya    81-25-266-5111    akiko-o@niigata-cc.jp   
National Hospital Organization Osaka National Hospital Recruiting
Osaka, Japan
Contact: Kaoru Ishiyama    81669463581    ishiyama@onh.go.jp   
Korea, Republic of
National Cancer Center, Center for Breast Cancer Recruiting
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769
Contact: Ji Hee Kim    +82-31-920-0417    73206@ncc.re.kr   
Seoul National University Bundang Hospital Recruiting
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707
Contact: Eun Kyung Kim    +82-31-787-4880    pulssaugi@naver.com   
Severance Hospital, Yonsei University Health System Recruiting
Seodaemun-Gu, Seoul, Korea, Republic of, 120-725
Contact: Are-rang Oh    +82-2-2228-8024    forefeel22@naver.com   
Seoul National University Hospital / Department of Internal Medicine Recruiting
Seoul, Korea, Republic of, 110-744
Contact: Hae Eun Kim       kheun8062@naver.com   
Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Ji Young Kwon    82-2-3410-0953    jiyoung31.kwon@samsung.com   
Asan Medical Center, Division of Oncology, Department of Internal Medicine Recruiting
Seoul, Korea, Republic of, 138-736
Contact: Shin Ae Park       55phon@amc.seoul.kr   
New Zealand
Christchurch Hospital Not yet recruiting
Christchurch, Canterbury, New Zealand, 8011
Contact: Katharine Moore    +64 3 364 1823    Katharine.moore@cdhb.health.nz   
Poland
Uniwersyteckie Centrum Kliniczne Recruiting
Gdansk, Poland, 80-952
Contact: Anita Zakrzewska    +48 58 349 2282    zakrzewska@gumed.edu.pl   
Europejskie Centrum Zdrowia Otwock Not yet recruiting
Otwock, Poland, 05-400
Contact: Magdalena Granat    48-22-6440024    magdac@coi.waw.pl   
Wojskowy Instytut Medyczny, Klinika Onkologii CSK MON, ul. Szaserow 128 Not yet recruiting
Warszawa, Poland, 04-141
Contact: Agata Kielkiewicz    48-22-6103098    akielkiewicz@wim.mil.pl   
Niepubliczny Zaklad Opieki Zdrowotnej �Onko-Dent� SP.P. G.L. Slomian Not yet recruiting
Zory, Poland, 44-240
Contact: Urszula Lanucha-Wajzer    +48 32 469 04 25    salomea@autograf.pl   
Russian Federation
Regional Budgetary Healthcare Institution Kursk Regional Clinical Not yet recruiting
Kursk, Kursk Region, Russian Federation
State Budget Healthcate Institution "Leningrad Region Oncology Dispensary" Not yet recruiting
Kuzmolovo, Leningrad region, Russian Federation, 188663
State Medical Care Institution Not yet recruiting
Chelyabinsk, Russian Federation, 454087
Contact: Julia Kruzhilina       krushilina46@gmail.com   
City Oncology Clinical Hospital #62, Chemotherapy Department Recruiting
Moscow, Russian Federation, 143423
State Budget Institution of Healthcare Recruiting
Omsk, Russian Federation, 644046
State Budget Institution of Healthcare Recruiting
Omsk, Russian Federation, 644013
Saint-Petersburg State Budget Healthcare Institution (SBHCI) Not yet recruiting
Saint-Petersburg, Russian Federation, 197022
Non-state institution of Healthcare "Railway Clinical Hospital at OJSC �RR� Recruiting
St. Petersburg, Russian Federation, 195271
State Budget Medical Institution Republican Clinical Oncology Recruiting
Ufa, Russian Federation, 450054
Contact: Leysyan Mirkhaydarova       lmirkhaydarova@bk.ru   
Spain
Hospital Universitari Germans Trias i Pujol Not yet recruiting
Badalona, Barcelona, Spain, 08916
Contact: Saudy Patricia Pelaez Bonilla    +34-934978729    pelaezbonilla.saudy@gmail.com   
Consorci Sanitari de Terrassa Recruiting
Terrassa, Barcelona, Spain, 08227
Contact: Carme Aracil    01134937003612    caracil@cst.cat   
Hospital Universitari Son Espases Recruiting
Palma de Mallorca, Islas Baleares, Spain, 07010
Contact: Joana Maria Mascaro Ferrer    +34-671-03-26-20    juanam.mascaro@ssib.es   
Hospital Universitario Fundacion de Alcorcon Recruiting
Alcorcon, Madrid, Spain, 28922
Contact: Ruth Martinez Caba�es    +34-916219256    rmartinezca@fhalcorcon.es   
Hospital Universitario Infanta Cristina Recruiting
Badajoz, Spain, 06080
Contact: Paloma Moyano Lopez    34 924 21 80 40 X 48350    palomamoyano@gmail.com   
Hospital Universitari Vall d'Hebron Recruiting
Barcelona, Spain, 08035
Contact: Anna Serrano Fargas    +34 93 274 60 00 X 4707    aserrano@vhebron.net   
Hospital Clinic I Provincial Recruiting
Barcelona, Spain, 08036
Contact: Montserrat Fontanillas Isern    +34932275400 x 3456    mfontani@clinic.cat   
Hospital del Mar Recruiting
Barcelona, Spain, 08003
Contact: Clara Carreras Vila    +34 93 248 36 09    CCarreras@imas.imim.es   
Hospital de Donostia Recruiting
Donostia- San Sebastian, Spain, 20014
Contact: Maria Diez Zubizarreta    +34-943006002    maria.diez@biodonostia.org   
Complejo Hospitalario de Jaen Recruiting
Jaen, Spain, 23007
Contact: Monica Fernandez Navarro    +34953220306    oncojaen@fibao.es   
Instituto Catalan de Oncologia L'Hospitalet Recruiting
L'Hospitalet de Llobregat (Barcelona), Spain, 08908
Contact: marta pamias nogue    +34-932607333    mpamies@iconcologia.net   
Centro Oncologico de Galicia Recruiting
La Coruna, Spain, 15009
Contact: Bego�a Uriarte Carbon    0034 981 287 499 Ext. 324    Uriarte.b@gmail.com   
Hospital Universitario de Canarias Recruiting
La Laguna (Santa Cruz de Tenerife), Spain, 38320
Contact: Lucas De Vera    +34922678745    lucasdevera.huc@hotmail.com   
Hospital Universitario Arnau De Vilanova de Lleida Recruiting
Lleida, Spain, 25198
Contact: David Martinez Ortin    +34973705342    eoncolleida@gmail.com   
Centro Oncologico MD Anderson Internacional Espa�a Recruiting
Madrid, Spain, 28033
Contact: Maria Jose Lopez de Paredes    01134917878600    mjlopez.fundacion@mdanderson.es   
Hospital Clinico San Carlos Recruiting
Madrid, Spain, 28040
Contact: Sara Fernandez Gonzalez    0034 91 330 30 00 ext 7545    sarafergon@hotmail.com   
Hospital 12 de Octubre Not yet recruiting
Madrid, Spain, 28041
Contact: Rosa Rodriguez Notario    +34 913908626    rrnotario@h12o.es   
Hospital General Universitario Gregorio Mara�on Recruiting
Madrid, Spain, 28007
Contact: Sara Fernandez Gonzalez    0034 91 330 30 00 ext 7545    sarafergon@hotmail.com   
Hospital Madrid Universitario Sanchinarro Not yet recruiting
Madrid, Spain, 28050
Contact: Miriam Delgado Sanchez    +34 91 756 78 00 Ext ? 4816    mdelgado@hmhospitales.com   
Hospital Universitario Virgen Macarena Recruiting
Sevilla, Spain, 41009
Contact: Maria Angeles Lobo Acosta    +34955926578    oncomacarena@gmail.com   
Hospital Universitario Virgen del Rocio Recruiting
Sevilla, Spain, 41013
Contact: Maria Angeles Oyarzabal Cespedes    01134955012000    ensayosclinicos.hvr.sspa@juntadeandalucia.es   
Instituto Valenciano de Oncologia Recruiting
Valencia, Spain, 46009
Contact: Laura Calabuig Bendicho    +34961114013    coordinacion@fincivo.org   
Taiwan
Veterans General Hospital-Taipei Not yet recruiting
Taipei, ROC, Taiwan, 112
Contact: Shu-Hui Yueh       oe0922@yahoo.com.tw   
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 106
Contact: Ching-Yueh Cheng       loverene5122@gmail.com   
Ukraine
Municipal Institution "City Multi-field Clinical Hospital #4 of Dnipropetrovsk Regional Council" Recruiting
Dnipropetrovsk, Ukraine, 49102
Contact: Iliya Balakin    380-56-377-7797    oncodsma@ukr.net   
Kharkiv Regional Clinical Oncology Hospital Recruiting
Kharkiv, Ukraine, 61070
Contact: Nataliia Kryzhanovska    +38 057 315 1248    natali.krz@gmail.com   
Lviv State Oncologic Regional Treatment and Diagnostic Center Recruiting
Lviv, Ukraine, 79031
Contact: Ivanna Duda    +38 032 295 6306    ivankaduda@ukr.net   
Makiivka City Hospital n2 of Donetsk Region Recruiting
Makiivka, Ukraine, 86120
Contact: Tetiana Kuliaba    +38 062 320 12 34    dubrova_t@mail.ru   
Sumy Regional Clinical Oncology Dispensary Recruiting
Sumy, Ukraine, 40005
Contact: Oleksandr I Vynnchenko    +380542781306    vynnychenkool@ukr.net   
Institute of Postgraduate education and preuniversity preparing of Uzhgorod National University Recruiting
Uzhgorod, Ukraine, 88000
Contact: Marta Melnyk    +380312642145    melnyk-m@yandex.ua   
Zaporizhzhia Regional Clinical Oncology Dispensary Recruiting
Zaporizhzhya, Ukraine, 69040
Contact: Feroz Shah    380-61-287-03-59    f_shah@ukr.net   
United Kingdom
Kent Oncology Department Recruiting
Maidstone, Kent, United Kingdom, ME16 9QQ
Contact: Clare Calvert    00 44 (0) 1622 227078    clare.calvert@nhs.net   
Medical Oncology, Christie Hospital Not yet recruiting
Withington, Manchester, United Kingdom, M20 4BX
Contact: Jagtar Sandhu    (0161) 446 8604    Jagtar.Sandhu@christie.nhs.uk   
Beatson Institute for Cancer Research Recruiting
Glasgow, Scotland, United Kingdom, G12 0YN
Contact: Jill Flemming    00 44 141 301 7230 ext internal 57    Jill.Fleming@glasgow.ac.uk   
The Royal Marsden NHS Foundation Trust Recruiting
Sutton, Surrey, United Kingdom, SM2 5PT
Contact: Lyra Del Rosario    0207 352 8171 ext: 2712 / 4652    Lyra.DelRosario@rmh.nhs.uk   
Western General Hospital Not yet recruiting
Edinburgh, United Kingdom, EH4 2XU
Contact: Paul Ramage       Paul.Ramage@nhslothian.scot.nhs.uk   
Charing Cross Hospital Recruiting
London, United Kingdom, W6 8RF
Contact: Kathryn Brownless    020 3313 0664    Kathryn.Brownless@imperial.nhs.uk   
Guy's and St. Thomas' NHS Foundation Trust Not yet recruiting
London, United Kingdom, SE1 9RT
Contact: Claire Partridge    0207 188 7188 ext 51694    claire.partridge@gstt.nhs.uk   
Sponsors and Collaborators
Pfizer
Investigators
Study Director: Pfizer CT.gov Call Center Pfizer
  More Information

Additional Information:
No publications provided

Responsible Party: Pfizer
ClinicalTrials.gov Identifier: NCT01740427     History of Changes
Other Study ID Numbers: A5481008
Study First Received: November 26, 2012
Last Updated: March 20, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Pfizer:
breast cancer
postmenopausal women
estrogen-receptor positive
HER2 negative
locoregionally recurrent
metastatic
Palbociclib (PD-0332991)
PALOMA-2

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Letrozole
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Aromatase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on April 23, 2014