Trial record 1 of 1 for:    Siponimod
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Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by Novartis
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
NCT01665144
First received: August 3, 2012
Last updated: May 21, 2014
Last verified: May 2014
  Purpose

Evaluate the safety and efficacy of Siponimod (BAF312) versus placebo in a variable treatment duration in patients with secondary progressive multiple sclerosis.


Condition Intervention Phase
Secondary Progressive Multiple Sclerosis
Drug: BAF312
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Variable Treatment Duration Study Evaluating the Efficacy and Safety of Siponimod (BAF312) in Patients With Secondary Progressive Multiple Sclerosis.

Resource links provided by NLM:


Further study details as provided by Novartis:

Primary Outcome Measures:
  • The delay in time to confirmed disability progression as measured by EDSS. [ Time Frame: Baseline, every 3 month up to the maximum of 60 months ] [ Designated as safety issue: No ]
    Confirmed disability is defined as an Increase of score of 1 point in patients with baseline score of 3.0 to 5.0 and 0.5 point increase with baseline score of 5.5 to 6.5.


Secondary Outcome Measures:
  • Efficacy of BAF312 relative to placebo in confirmed worsening of 25 foot walk test [ Time Frame: Baseline , every 3 months up to the maximum of 60 months ] [ Designated as safety issue: No ]
    Delay in time to 3 month confirmed worsening of at least 20% from baseline in the timed 25 foot walk test.

  • Efficacy of BAF312 relative to placebo in reducing the increase in T2 lesion volume [ Time Frame: Baseline, every year up to the maximum of 5 years ] [ Designated as safety issue: No ]
    The reduction of the increase in the T1 lesion volume.

  • The delay in time to confirmed disability progression as measured by EDSS. [ Time Frame: Baseline, every 6 months up to the maximum of 60 months ] [ Designated as safety issue: No ]
    Confirmed disability is defined as increase of score of 1 point in patients with baseline score of 3.0 to 5.0 and 0.5 point increase with baseline score of 5.5 to 6.5.

  • Efficacy of BAF relative to placebo in annualized relapses rate and time to the first relapse [ Time Frame: Baseline every 3 months up to the maximum of 60 months ] [ Designated as safety issue: No ]
    BAF312 vs placebo measured by the effect on confirmed relapses rate, the time to the first relapse, and proportion of patient free from relapses.

  • Overall response rate on the MSWS-12. [ Time Frame: Baseline, every 6 months up to the maximum of 60 months ] [ Designated as safety issue: No ]
    The overall response of the effect of BAF312 compared to placebo patients on the patient reported outcome form MSWS-12.

  • Effect on inflammatory disease activity and burden of disease as measured by MRI [ Time Frame: Baseline, every 12 month up to the maximum of 60 months ] [ Designated as safety issue: No ]
    Effect of BAF312 relative to placebo on disease activity and burden of disease as measured by Gd-T1 lesion, new/enlarged T2 lesion, and brain atrophy on brain MRI scans.

  • effect on 3-month confirmed disability progression as defined by EDSS in predefined sub-groups [ Time Frame: Baseline, every 3 months up to the maximum of 60 months ] [ Designated as safety issue: No ]
    effect on confirmed disability progression in pre-defined subgroups, including patients with or without superimposed relapses, rapidly evolving patients with 1.5 point or greater change in EDSS score in 2 years prior to enrollment into the study. Patients with score of 4 or more in MSSS and those who don't meet this criteria.

  • Number of patients with adverse event [ Time Frame: Baseline, every 3 months up to the maximum of 60 months ] [ Designated as safety issue: Yes ]
    Safety analysis will be performed on AE by CTCAE grade, serious AEs and Study drug related AEs and the AEs leading to discontinuation of study drug.

  • Number of patients with abnormal lab tests [ Time Frame: Baseline, every 3 months up to the maximum of 60 months ] [ Designated as safety issue: Yes ]
    Safety analysis will be performed on lab abnormalities will be based on CTCAE grades


Estimated Enrollment: 1530
Study Start Date: December 2012
Estimated Study Completion Date: March 2017
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: BAF312
1020 patients will be randomized to receive BAF312 during the trial for a duration of 23 to 42 months with a maximum of 60 months. Patients who meet all inclusion and none of the exclusion criteria will be treated with BAF312 daily.
Drug: BAF312
Patients will be randomized to receive BAF312. BAF312 will be provided in a dose titration from 0.25 mg to a 2 mg dose.
Placebo Comparator: Placebo
Matching Placebo administered orally.
Drug: Placebo
Placebo

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Prior history of relapsing remitting MS
  • SPMS defined as progressive increase of disability over at least 6 months
  • EDSS score of 3.0 to 6.5
  • No relapse of corticosteroid treatment within 3 months

Exclusion Criteria:

  • Women of child bearing potential must use reliable forms of contraception.
  • Diagnosis of Macular edema during screening period
  • Any medically unstable condition determined by investigator.
  • Unable to undergo MRI scans
  • Hypersensitivity to any study drugs or drugs of similar class Other protocol defined inclusion/exclusion may apply.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01665144

Contacts
Contact: Novartis Pharmaceuticals 1-888-669-6682
Contact: Novartis Pharmaceuticals

  Hide Study Locations
Locations
United States, Alabama
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Cullman, Alabama, United States, 35058
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Mobile, Alabama, United States, 36693
United States, Arizona
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Phoenix, Arizona, United States, 85032
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Phoenix, Arizona, United States, 85006
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Scottsdale, Arizona, United States, 85259
United States, California
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Berkeley, California, United States, 94705
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Loma Linda, California, United States, 92354
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Los Angeles, California, United States, 90033
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Oceanside, California, United States, 92056
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Sacramento, California, United States, 95816
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Sacramento, California, United States, 95817
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San Francisco, California, United States, 94117
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Stanford, California, United States, 94304
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Torrance, California, United States, 90509-2004
United States, Colorado
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Aurora, Colorado, United States, 80045
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Basalt, Colorado, United States, 81621
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Boulder, Colorado, United States, 80304
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Centennial, Colorado, United States, 80112
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Colorado Springs, Colorado, United States, 80910
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Englewood, Colorado, United States, 80113
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Fort Collins, Colorado, United States, 80528
United States, Connecticut
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Danbury, Connecticut, United States, 06810
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Fairfield, Connecticut, United States, 06824
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North Haven, Connecticut, United States, 06473
United States, Delaware
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Newark, Delaware, United States, 19713
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Newark, Delaware, United States, 19713
United States, District of Columbia
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Washington, District of Columbia, United States, 20007
United States, Florida
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Boca Raton, Florida, United States, 33431
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Delray Beach, Florida, United States, 33445
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Fort Lauderdale, Florida, United States, 33308
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Jacksonville, Florida, United States, 32209
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Maitland, Florida, United States, 32751
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Miami, Florida, United States, 33126
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Miami, Florida, United States, 33136
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Ormond Beach, Florida, United States, 32174
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Pembroke Pines, Florida, United States, 33024
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Pensacola, Florida, United States, 32514
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Pompano Beach, Florida, United States, 33060
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St. Petersburg, Florida, United States, 33713
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Sunrise, Florida, United States, 33351
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Tallahassee, Florida, United States, 32308
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Tampa, Florida, United States, 33609
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Tampa, Florida, United States, 33612
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Vero Beach, Florida, United States, 32960
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West Palm Beach, Florida, United States, 33407
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Weston, Florida, United States, 33331
United States, Illinois
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Chicago, Illinois, United States, 60637
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Chicago, Illinois, United States, 60612
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Evanston, Illinois, United States, 60201
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Louisville, Kentucky, United States, 40202
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Boston, Massachusetts, United States, 02115
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Lexington, Massachusetts, United States, 02421
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Worchester, Massachusetts, United States, 01608
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Ann Arbor, Michigan, United States, 48109
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Detroit, Michigan, United States, 48202
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Detroit, Michigan, United States, 48201
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Farmington Hills, Michigan, United States, 48334
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Grand Rapids, Michigan, United States, 49503
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Golden Valey, Minnesota, United States, 55422
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Minneapolis, Minnesota, United States, 55455
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Las Vegas, Nevada, United States, 89106
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Lebanon, New Hampshire, United States, 03756
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Freehold, New Jersey, United States, 07728
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Teaneck, New Jersey, United States, 07666
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Toms River, New Jersey, United States, 08755
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Voorhees, New Jersey, United States, 08043
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Albuquerque, New Mexico, United States, 87131-0001
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Albany, New York, United States, 12208
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Amherst, New York, United States, 14226
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Bronx, New York, United States, 10467
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Buffalo, New York, United States, 14203
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Latham, New York, United States, 12110
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Mineola, New York, United States, 11501
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New York, New York, United States, 10029
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New York, New York, United States, 10016
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Patchogue, New York, United States, 11772
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Plainview, New York, United States, 11803
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Rochester, New York, United States, 14642
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Stony Brook, New York, United States, 11794
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Syracuse, New York, United States, 13210
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Charlotte, North Carolina, United States, 28209
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Charlotte, North Carolina, United States, 28207
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Durham, North Carolina, United States, 27710
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Dayton, Ohio, United States, 45408
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Nashville, Tennessee, United States, 37212
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Kingwood, Texas, United States, 77339
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Lubbock, Texas, United States, 79410
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Round Rock, Texas, United States, 78681
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San Antonio, Texas, United States, 78258
United States, Vermont
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Burlington, Vermont, United States, 05401
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Alexandria, Virginia, United States, 22310
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Seattle, Washington, United States, 98122
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Seattle, Washington, United States, 98101
United States, Wisconsin
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Green Bay, Wisconsin, United States, 54311
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Madison, Wisconsin, United States, 53792
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Milwaukee, Wisconsin, United States, 53215
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Waukesha, Wisconsin, United States, 53188
Argentina
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C A B A, Buenos Aires, Argentina, C1055AAF
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Caba, Buenos Aires, Argentina, C1181ACH
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Caba, Buenos Aires, Argentina, C1280AEB
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Caba, Buenos Aires, Argentina, C1428AQK
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Caba, Buenos Aires, Argentina, 1425
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Capital Federal, Buenos Aires, Argentina, 1424
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San Isidro, Buenos Aires, Argentina, B1642DCD
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Buenos Aires, Argentina, 1061
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Cordoba, Argentina, X5000FAL
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Salta, Argentina
Australia, New South Wales
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Camperdown, New South Wales, Australia, 2050
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Kogarah, New South Wales, Australia, 2217
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Liverpool, New South Wales, Australia, 2170
Australia, Victoria
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Box Hill, Victoria, Australia, 3128
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Heidelberg, Victoria, Australia, 3084
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Parkville, Victoria, Australia, 3050
Austria
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Klagenfurt, Austria, 9020
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Vienna, Austria, 1010
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Vienna, Austria, 1090
Belgium
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Brugge, Belgium, 8000
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Bruxelles, Belgium, 1070
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Edegem, Belgium, 2650
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Gent, Belgium, 9000
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Leuven, Belgium, 3000
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Overpelt, Belgium, 3900
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Sijsele, Belgium, 8340
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Tinlot (Fraiture), Belgium, 4557
Bulgaria
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Sofia, Bulgaria, 1431
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Sofia, Bulgaria, 1612
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Sofia, Bulgaria, 1113
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Varna, Bulgaria, 9010
Canada, Alberta
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Calgary, Alberta, Canada, T2N 2T9
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Edmonton, Alberta, Canada, T6G 2G3
Canada, British Columbia
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Burnaby, British Columbia, Canada, V5G 2X6
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Victoria, British Columbia, Canada, V8R 1J8
Canada, Manitoba
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Winnipeg, Manitoba, Canada, R3E 3P4
Canada, Newfoundland and Labrador
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St. John, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 4K4
Canada, Ontario
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Kingston, Ontario, Canada, K7L 2V7
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Nepean, Ontario, Canada, K2G 6E2
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Ottawa, Ontario, Canada, K1H 8L6
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Toronto, Ontario, Canada, M5B 1N9
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Toronto, Ontario, Canada, M4N 3M5
Canada, Quebec
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Greenfield Park, Quebec, Canada, J4V 2J2
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Montreal, Quebec, Canada, H2L 4M1
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Montreal, Quebec, Canada, H3A 2B4
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Montreal, Quebec, Canada, H3T 1E2
Canada, Saskatchewan
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Regina, Saskatchewan, Canada, S4T 1A5
Canada
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Quebec, Canada, G1J 1Z4
China, Beijing
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Beijing, Beijing, China
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Beijing, Beijing, China, 100034
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Beijing, Beijing, China, 100730
China, Jilin
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Changchun, Jilin, China, 130021
China, Shanxi
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Taiyuan, Shanxi, China, 030001
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Xi'an, Shanxi, China, 710038
China, Sichuan
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Chengdu, Sichuan, China, 610041
China
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Beijing, China, 100176
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Beijing, China, 100730
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Beijing, China, 100053
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Beijing, China, 100028
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Shanghai, China, 200025
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Shanghai, China, 200003
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Shanghai, China, 200040
Czech Republic
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Brno, Czech Rep., Czech Republic, 625 00
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JIhlava, Czech Republic, 586 33
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Prague 5, Czech Republic, 150 00
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Praha 2, Czech Republic, 128 08
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Teplice, Czech Republic, 415 01
Egypt
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Alexandria, Egypt
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Cairo, Egypt
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Giza, Egypt, 11451
Estonia
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Tallinn, Estonia, 10617
Novartis Investigative Site Active, not recruiting
Tallinn, Estonia, 10138
France
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Bordeaux Cedex, France, F-33076
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CAEN Cedex, France, 14033
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Lille Cedex, France, 59037
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Lyon, France, 69005
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Marseille, France, 13385
Novartis Investigative Site Recruiting
Montpellier, France, 34295
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Nancy, France, 54035
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Nimes, France, 30029
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Paris Cedex 13, France, 75651
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Rennes, France, F-35043
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St Herblain, France, 44800
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Strasbourg, France, 67091
Germany
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Aschaffenburg, Germany, 63739
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Bad Mergentheim, Germany, 97980
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Bayreuth, Germany, 95445
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Berg, Germany, 82335
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Berlin, Germany, 10713
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Berlin, Germany, 13347
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Bielefeld, Germany, 33647
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Bochum, Germany, 44791
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Bonn, Germany, 53111
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Böblingen, Germany, 71032
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Dresden, Germany, 01307
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Düsseldorf, Germany, 40225
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Erbach, Germany, 64711
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Erlangen, Germany, 91054
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Frankfurt, Germany, 60313
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Freiburg, Germany, 79106
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Hamburg, Germany, 22083
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Hamburg, Germany, 20249
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Hannover, Germany, 30625
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Hannover, Germany, 30161
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Hannover, Germany, 30559
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Heidelberg, Germany, 69120
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Homburg, Germany, 66421
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Itzehoe, Germany, 25524
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Jena, Germany, 07740
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Kandel, Germany, 76870
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Kassel, Germany, 34121
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Koeln, Germany, 51109
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Leipzig, Germany, 04107
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Leipzig, Germany, 04103
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München, Germany, 81675
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Münster, Germany, 48149
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Neuburg, Germany, 86633
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Oldenburg, Germany, 26122
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Potsdam, Germany, 14471
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Prien, Germany, 83209
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Regensburg, Germany, 93053
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Rostock, Germany, 18057
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Schwendi, Germany, 88477
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Siegen, Germany, 57076
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Stade, Germany, 21682
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Stadtroda, Germany, 07646
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Teupitz, Germany, 15755
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Tuebingen, Germany, 72076
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Ulm, Germany, 89073
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Ulm, Germany, 89081
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Unterhaching, Germany, 82008
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Wiesbaden, Germany, 65191
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Würzburg, Germany, 97080
Greece
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Heraklion Crete, Crete, Greece, GR-71110
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Athens - GR, Greece, GR 10676
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Larissa, Greece, GR 41110
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Thessaloniki, Greece, 54636
Hungary
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Balassagyarmat, Hungary, 2660
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Budapest, Hungary, 1076
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Budapest, Hungary, H-1106
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Budapest, Hungary, 1145
Novartis Investigative Site Recruiting
Budapest, Hungary, 1085
Novartis Investigative Site Recruiting
Budapest, Hungary, 1204
Novartis Investigative Site Recruiting
Eger, Hungary, H-3300
Novartis Investigative Site Recruiting
Esztergom, Hungary, 2500
Novartis Investigative Site Completed
Gyor, Hungary, 9024
Novartis Investigative Site Recruiting
Miskolc, Hungary, 3526
Novartis Investigative Site Recruiting
Nyiregyhaza, Hungary, 4400
Novartis Investigative Site Recruiting
Veszprem, Hungary, H-8200
Ireland
Novartis Investigative Site Not yet recruiting
Cork, Ireland
Novartis Investigative Site Recruiting
Dublin 4, Ireland
Novartis Investigative Site Recruiting
Dublin 9, Ireland
Israel
Novartis Investigative Site Recruiting
Jerusalem, Israel, 91120
Novartis Investigative Site Recruiting
Ramat Gan, Israel, 52621
Novartis Investigative Site Recruiting
Tel-Aviv, Israel, 64239
Italy
Novartis Investigative Site Recruiting
Genova, GE, Italy, 16132
Novartis Investigative Site Recruiting
Milano, MI, Italy, 20122
Novartis Investigative Site Recruiting
Milano, MI, Italy, 20132
Novartis Investigative Site Recruiting
Cefalù, PA, Italy, 90015
Novartis Investigative Site Recruiting
Roma, RM, Italy, 00161
Novartis Investigative Site Recruiting
Roma, RM, Italy, 00179
Novartis Investigative Site Recruiting
Roma, RM, Italy, 00133
Novartis Investigative Site Recruiting
Roma, RM, Italy, 00152
Novartis Investigative Site Recruiting
Roma, RM, Italy, 00168
Novartis Investigative Site Recruiting
Napoli, Italy, 80131
Japan
Novartis Investigative Site Not yet recruiting
Chiba-city, Chiba, Japan, 260-8677
Novartis Investigative Site Not yet recruiting
Toon-city, Ehime, Japan, 791-0295
Novartis Investigative Site Not yet recruiting
Fukuoka-city, Fukuoka, Japan, 812-8582
Novartis Investigative Site Not yet recruiting
Asahikawa-city, Hokkaido, Japan, 070-8644
Novartis Investigative Site Not yet recruiting
Sapporo-city, Hokkaido, Japan, 063-0005
Novartis Investigative Site Not yet recruiting
Tsukuba-city, Ibaraki, Japan, 305-8576
Novartis Investigative Site Not yet recruiting
Morioka-city, Iwate, Japan, 020-8505
Novartis Investigative Site Not yet recruiting
Kyoto-city, Kyoto, Japan, 604-8453
Novartis Investigative Site Not yet recruiting
Sendai-city, Miyagi, Japan, 980-8574
Novartis Investigative Site Not yet recruiting
Niigata-city, Niigata, Japan, 951-8520
Novartis Investigative Site Not yet recruiting
Osaka-city, Osaka, Japan, 556-0016
Novartis Investigative Site Not yet recruiting
Suita-city, Osaka, Japan, 565-0871
Novartis Investigative Site Not yet recruiting
Kawagoe-city, Saitama, Japan, 350-8550
Novartis Investigative Site Not yet recruiting
Kodaira-city, Tokyo, Japan, 187-8551
Novartis Investigative Site Not yet recruiting
Ota-ku, Tokyo, Japan, 145-0065
Novartis Investigative Site Not yet recruiting
Shinjuku-ku, Tokyo, Japan, 162-8666
Novartis Investigative Site Not yet recruiting
Shinjuku-ku, Tokyo, Japan, 160-8582
Novartis Investigative Site Not yet recruiting
Aomori, Japan, 030-8553
Latvia
Novartis Investigative Site Recruiting
Riga, LV, Latvia, LV-1005
Novartis Investigative Site Recruiting
Riga, Latvia, LV-1038
Novartis Investigative Site Recruiting
Riga, Latvia, 1002
Lithuania
Novartis Investigative Site Recruiting
Kaunas, Lithuania, 50009
Novartis Investigative Site Recruiting
Klaipeda, Lithuania, 92288
Novartis Investigative Site Recruiting
Vilnius, Lithuania, LT-08661
Netherlands
Novartis Investigative Site Recruiting
Amsterdam, Netherlands, 1105 AZ
Novartis Investigative Site Recruiting
Breda, Netherlands, 4818 CK
Novartis Investigative Site Recruiting
Eindhoven, Netherlands, 5623 EJ
Novartis Investigative Site Recruiting
Hoorn, Netherlands, 1624 NP
Novartis Investigative Site Withdrawn
Nieuwegein, Netherlands, 3435 CM
Novartis Investigative Site Withdrawn
Nijmegen, Netherlands, 6525 GC
Novartis Investigative Site Recruiting
Sittard-Geleen, Netherlands, 6162 BG
Novartis Investigative Site Recruiting
Tilburg, Netherlands, 5022 GC
Poland
Novartis Investigative Site Recruiting
Grudziadz, Poland, 86-300
Novartis Investigative Site Recruiting
Katowice, Poland, 40-595
Novartis Investigative Site Recruiting
Kielce, Poland, 25-726
Novartis Investigative Site Recruiting
Konskie, Poland, 26-200
Novartis Investigative Site Recruiting
Krakow, Poland, 31-637
Novartis Investigative Site Recruiting
Lodz, Poland, 93-121
Novartis Investigative Site Recruiting
Poznan, Poland, 60-355
Novartis Investigative Site Recruiting
Warszawa, Poland, 02-957
Novartis Investigative Site Withdrawn
Warszawa, Poland, 04-749
Portugal
Novartis Investigative Site Recruiting
Amadora, Portugal, 2720-276
Novartis Investigative Site Recruiting
Braga, Portugal, 4710-243
Novartis Investigative Site Recruiting
Coimbra, Portugal, 3000-075
Novartis Investigative Site Recruiting
Lisboa, Portugal, 1649-035
Novartis Investigative Site Recruiting
Porto, Portugal, 4099-001
Romania
Novartis Investigative Site Recruiting
Constanta, Jud. Constanta, Romania, 900591
Novartis Investigative Site Recruiting
Bucharest, Romania, 020125
Novartis Investigative Site Recruiting
Bucharest, Romania, 050098
Novartis Investigative Site Recruiting
Cluj Napoca, Romania, 400006
Novartis Investigative Site Recruiting
Craiova, Romania, 200620
Novartis Investigative Site Recruiting
Iasi, Romania, 700656
Novartis Investigative Site Recruiting
Suceava, Romania, 727525
Novartis Investigative Site Recruiting
Targu Mures, Romania, 540136
Novartis Investigative Site Recruiting
Timisoara, Romania, 300736
Russian Federation
Novartis Investigative Site Recruiting
Barnaul, Russian Federation, 656024
Novartis Investigative Site Recruiting
Kazan, Russian Federation, 420097
Novartis Investigative Site Recruiting
Kazan, Russian Federation, 420021
Novartis Investigative Site Terminated
Kursk, Russian Federation, 305007
Novartis Investigative Site Recruiting
Moscow, Russian Federation, 119049
Novartis Investigative Site Recruiting
Moscow, Russian Federation, 127018
Novartis Investigative Site Withdrawn
Nizhniy Novgorod, Russian Federation, 603076
Novartis Investigative Site Recruiting
Novosibirsk, Russian Federation, 630087
Novartis Investigative Site Recruiting
Saint-Petersburg, Russian Federation, 194044
Novartis Investigative Site Recruiting
St. Petersburg, Russian Federation, 197376
Novartis Investigative Site Recruiting
St. Petersburg, Russian Federation, 197119
Novartis Investigative Site Recruiting
Ufa, Russian Federation, 450000
Novartis Investigative Site Recruiting
Yaroslavl, Russian Federation, 150030
Slovakia
Novartis Investigative Site Recruiting
Banska Bystrica, Slovakia, 97517
Novartis Investigative Site Recruiting
Bratislava, Slovakia, 826 06
Novartis Investigative Site Recruiting
Bratislava, Slovakia, 813 69
Novartis Investigative Site Recruiting
Martin, Slovakia, 036 59
Novartis Investigative Site Recruiting
Nitra, Slovakia, 94911
Novartis Investigative Site Recruiting
Presov, Slovakia, 080 01
Novartis Investigative Site Recruiting
Trencin, Slovakia, 91171
Novartis Investigative Site Recruiting
Trnava, Slovakia, 917 75
Spain
Novartis Investigative Site Recruiting
Málaga, Andalucia, Spain, 29010
Novartis Investigative Site Recruiting
Sevilla, Andalucia, Spain, 41009
Novartis Investigative Site Withdrawn
Valladolid, Castilla y Leon, Spain, 47011
Novartis Investigative Site Recruiting
Badalona, Catalunya, Spain, 08916
Novartis Investigative Site Recruiting
Barcelona, Catalunya, Spain, 08035
Novartis Investigative Site Recruiting
Barcelona, Cataluña, Spain, 08041
Novartis Investigative Site Recruiting
Barcelona, Cataluña, Spain, 08003
Novartis Investigative Site Recruiting
L'Hospitalet de Llobregat, Cataluña, Spain, 08907
Novartis Investigative Site Recruiting
Valencia, Comunidad Valenciana, Spain, 46010
Novartis Investigative Site Recruiting
Valencia, Comunidad Valenciana, Spain, 46026
Novartis Investigative Site Recruiting
Santiago de Compostela, Galicia, Spain, 15706
Novartis Investigative Site Recruiting
Majadanonda, Madrid, Spain, 28220
Novartis Investigative Site Recruiting
El Palmar, Murcia, Spain, 30120
Novartis Investigative Site Recruiting
Bilbao, Pais Vasco, Spain, 48013
Novartis Investigative Site Recruiting
San Sebastian, Pais Vasco, Spain, 20014
Novartis Investigative Site Recruiting
Madrid, Spain, 28040
Sweden
Novartis Investigative Site Recruiting
Göteborg, Sweden, 413 45
Novartis Investigative Site Recruiting
Stockholm, Sweden, 17176
Novartis Investigative Site Recruiting
Stockholm, Sweden, 141 86
Switzerland
Novartis Investigative Site Recruiting
Aarau, CH, Switzerland, 5001
Novartis Investigative Site Recruiting
Basel, Switzerland, 4031
Novartis Investigative Site Recruiting
Lausanne, Switzerland, 1011
Novartis Investigative Site Recruiting
Lugano, Switzerland, 6900
Novartis Investigative Site Not yet recruiting
Luzern, Switzerland, 6000
Novartis Investigative Site Recruiting
St. Gallen, Switzerland, 9007
Novartis Investigative Site Recruiting
Zuerich, Switzerland, 8091
Turkey
Novartis Investigative Site Recruiting
Altunizade, Turkey, 34662
Novartis Investigative Site Recruiting
Atakum / Samsun, Turkey, 55139
Novartis Investigative Site Recruiting
Haseki / Istanbul, Turkey, 34096
Novartis Investigative Site Recruiting
Istanbul, Turkey, 34303
Novartis Investigative Site Recruiting
Kocaeli, Turkey, 41380
Novartis Investigative Site Recruiting
Mecidiyekoy/Istanbul, Turkey, 34394
Novartis Investigative Site Recruiting
Trabzon, Turkey, 61080
United Kingdom
Novartis Investigative Site Withdrawn
Truro, Cornwall, United Kingdom, TR1 3LJ
Novartis Investigative Site Recruiting
Salford, Manchester, United Kingdom, M6 8HD
Novartis Investigative Site Recruiting
Headington, Oxfordshire, United Kingdom, OX3 9DU
Novartis Investigative Site Recruiting
Bristol, United Kingdom, BS16 1LE
Novartis Investigative Site Withdrawn
Dundee, United Kingdom, DD1 9SY
Novartis Investigative Site Recruiting
Glasgow, United Kingdom, G11 6NT
Novartis Investigative Site Recruiting
Leeds, United Kingdom, LS1 3EX
Novartis Investigative Site Recruiting
Leicester, United Kingdom, LE5 4PW
Novartis Investigative Site Recruiting
London, United Kingdom, W8 6RF
Novartis Investigative Site Recruiting
London, United Kingdom, EC1A 7BE
Novartis Investigative Site Not yet recruiting
Newcastle Upon Tyne, United Kingdom, NE1 4LP
Novartis Investigative Site Recruiting
Sheffield, United Kingdom, S10 2JF
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

No publications provided

Responsible Party: Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier: NCT01665144     History of Changes
Other Study ID Numbers: CBAF312A2304
Study First Received: August 3, 2012
Last Updated: May 21, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Novartis:
Secondary Progressive Multiple Sclerosis

Additional relevant MeSH terms:
Multiple Sclerosis
Sclerosis
Multiple Sclerosis, Chronic Progressive
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on August 21, 2014