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Bananas as an Energy Source During Exercise: a Metabolomics Approach

This study has been completed.
Sponsor:
Collaborator:
Dole Foods
Information provided by (Responsible Party):
David C. Nieman, Appalachian State University
ClinicalTrials.gov Identifier:
NCT01581190
First received: April 14, 2012
Last updated: April 18, 2012
Last verified: April 2012
History of Changes
  Purpose

This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based profiling.


Condition Intervention
Intense Exercise
 Dietary Supplement: Bananas versus 6% carbohydrate beverage

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Comparison of Bananas and Gatorade on Performance and Exercise-induced Inflammation, Oxidative Stress, and Changes in Immune Function in Endurance Athletes

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Appalachian State University:

Primary Outcome Measures:
  • Performance and fuel substrate utilization as measured through metabolomics [ Time Frame: Up to 6 months ] [ Designated as safety issue: No ]
    Will measure shifts in metabolites following 75-km cycling while ingesting bananas or 6% carbohydrate beverage. The shift in metabolites will be assessed using GC-MS. Time frame from date of randomization until the last samples are collected and analyzed will be up to six months.


Secondary Outcome Measures:
  • Exercise-induced inflammation. [ Time Frame: up to 6 months ] [ Designated as safety issue: No ]
    Cytokine panel (IL-6, IL-8, IL-10, TNF-alpha) before and after cycling 75-km; measured with Meso Scale Discovery in pg/ml. Time frame from randomization until the last samples are collected and analyzed will be up to six months.


Enrollment: 14
Study Start Date: September 2011
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Bananas versus 6% carbohydrate beverage Dietary Supplement: Bananas versus 6% carbohydrate beverage
Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min).
Other Name: Gatorade

Detailed Description:

Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min). Pre-, post-, and 1-h-post-exercise blood samples were analyzed for glucose, granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity, nine cytokines, F2-isoprostanes, ferric reducing ability of plasma (FRAP), and metabolic profiles using gas chromatography-mass spectrometry.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Ages 18-45 years
  • Cyclists, road racing experience.
  • Willing to avoid the use of supplements, herbs, medications during the study.

Exclusion Criteria:

  • Female
  • Over the age of 45 years
  • No cycling racing experience
  • Using supplements and medications during the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01581190

Locations
United States, North Carolina
Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081
Sponsors and Collaborators
Appalachian State University
Dole Foods
Investigators
Principal Investigator: David C Nieman, DrPH Appalachian State University
  More Information

Additional Information:
Website for lab  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: David C. Nieman, Professor, Director of the Human Performance Lab, Appalachian State University
ClinicalTrials.gov Identifier: NCT01581190     History of Changes
Other Study ID Numbers: 11-0082
Study First Received: April 14, 2012
Last Updated: April 18, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Appalachian State University:
Bananas
Exercise
Metabolomics
 Oxidative stress
Inflammation
Immune function

Additional relevant MeSH terms:
Inflammation
Pathologic Processes

ClinicalTrials.gov processed this record on June 18, 2013