Trial record 1 of 6 for:    E2810
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Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01575548
First received: April 10, 2012
Last updated: October 17, 2014
Last verified: October 2014
  Purpose

This randomized phase III trial studies how well pazopanib hydrochloride works compared to placebo in treating patients with metastatic kidney cancer who have no evidence of disease after surgery. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.


Condition Intervention Phase
Clear Cell Renal Cell Carcinoma
Recurrent Renal Cell Cancer
Stage IV Renal Cell Cancer
Drug: pazopanib hydrochloride
Other: placebo
Other: quality-of-life assessment
Other: questionnaire administration
Other: pharmacological study
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Randomized, Double-Blind Phase III Study of Pazopanib vs. Placebo in Patients With Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Disease-free survival (DFS) [ Time Frame: Time from randomization to recurrence, development of second primary cancer, or death from any cause, assessed up to 10 years ] [ Designated as safety issue: No ]
    Spearman's Rank Correlation Coefficient will be calculated to test whether there is a relationship between pazopanib hydrochloride trough levels and DFS.


Secondary Outcome Measures:
  • Overall survival [ Time Frame: Time from randomization to date of death, assessed up to 10 years ] [ Designated as safety issue: No ]
    Overall survival for each treatment group will be partitioned into three health states: toxicity (TOX), time without symptoms of disease or toxicity (TWiST), and recurrence (REC).

  • Toxicity as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 30 days ] [ Designated as safety issue: Yes ]
  • Change in Q-TWiST between the two arms as assessed by the European Quality of Life 5-Dimensions (EQ-5D) [ Time Frame: From baseline to up to 10 years ] [ Designated as safety issue: No ]
    The mean amount of time in each state will be estimated using the method of Kaplan and Meier (1958).

  • Change in fatigue as assessed by Patient Reported Outcome Measurement Information System (PROMIS) Fatigue and Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue subscales [ Time Frame: From baseline to 15 months ] [ Designated as safety issue: No ]
  • Change in kidney cancer-related symptoms as assessed by the Functional Assessment of Cancer Therapy-Kidney Cancer Symptom Index (FKSI-15) [ Time Frame: From baseline to 15 months ] [ Designated as safety issue: No ]
  • Plasma trough levels of pazopanib hydrochloride [ Time Frame: Day 1 of course 2 ] [ Designated as safety issue: No ]
    The association of plasma trough levels of pazopanib hydrochloride with disease-free and overall survival will be explored.


Estimated Enrollment: 180
Study Start Date: August 2012
Estimated Primary Completion Date: August 2022 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (pazopanib hydrochloride)
Patients receive pazopanib hydrochloride PO QD on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Drug: pazopanib hydrochloride
Given PO
Other Names:
  • GW786034B
  • Votrient
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Other: questionnaire administration
Ancillary studies
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies
Placebo Comparator: Arm II (placebo)
Patients receive placebo PO QD on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Other: placebo
Given PO
Other Name: PLCB
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Other: questionnaire administration
Ancillary studies
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies

Detailed Description:

PRIMARY OBJECTIVES:

I. To evaluate disease-free survival with pazopanib (pazopanib hydrochloride) as compared to placebo, defined as the time from randomization to the development of recurrent disease, second primary cancer (other than localized breast, localized prostate, or non-melanoma skin cancer) or death from any cause for patients with metastatic renal cell carcinoma (RCC) with no evidence of disease following metastatectomy.

SECONDARY OBJECTIVES:

I. To describe the overall survival of patients with advanced RCC randomly assigned to receive placebo or pazopanib for one year following metastatectomy to no evidence of disease (NED).

II. To describe treatment- and (at recurrence) disease-related adverse events in the two treatment arms.

III. To analyze quality-adjusted time without symptoms of disease or treatment (Q-TWiST) for subjects in the two treatment arms.

IV. To characterize changes in patient-reported fatigue and (at recurrence) kidney cancer-related symptoms during and following treatment with pazopanib compared to placebo.

V. To explore the association between plasma trough levels of pazopanib and disease-free and overall survival.

VI. To prospectively bank preserved tissue from primary tumors and associated metastatic sites in patients with RCC.

OUTLINE: Patients are randomized to 1of 2 treatment arms.

ARM I: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive placebo PO QD on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for the first two years, every 6 months for the next 3 years, and then annually through 10 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patient must have pathologically confirmed renal cell carcinoma with a clear cell component; pure papillary and chromophobe histologies are excluded; there must be pathologic confirmation of metastatic disease in the resected metastatectomy specimen
  • Patient must have undergone nephrectomy or partial nephrectomy to remove primary renal cell carcinoma (at any time in the past)
  • Patient must have undergone surgical resection to remove one or more sites of metastatic disease, with successful removal of all known sites 2-12 weeks prior to randomization; any number of prior metastatectomies may have been performed in the past, so long as the most recent procedure was within the 12 weeks of registration; the most recent procedure may be nephrectomy for a renal primary tumor
  • Patients with synchronous disease at initial diagnosis must have metastatic (M1) disease (American Joint Committee on Cancer [AJCC] 7th edition T1-4N0-1M1)
  • Positive surgical margins are permitted if the surgeon confirms complete resection of gross metastatic disease, and post-operative scans are negative
  • Patients presenting with metachronous disease may have distant metastases, regional lymph node or renal bed recurrence; recurrences at a partial nephrectomy resection site are not eligible if it is the only site of disease
  • Patients presenting with tumors within the kidneys (multiple synchronous or single/multiple metachronous) are not eligible if there are no extrarenal sites of disease (i.e. potential multifocal primary disease)
  • Patient must have no evidence of disease on post-operative imaging:

    • A computed tomography (CT) of the chest must be obtained within 4 weeks prior to randomization with or without contrast
    • A CT of the abdomen/pelvis must be obtained within 4 weeks prior to randomization with intravenous (IV) contrast (oral contrast may be added at the radiologist's discretion); an MRI of the abdomen/pelvis with gadolinium may be substituted for the CT if the CT with IV contrast is contra-indicated
    • An MRI of the brain with and without gadolinium must be done within 8 weeks prior to randomization; a CT of the brain with and without IV contrast is permitted if MRI is contra-indicated (i.e., pacemaker)
  • Patient must not have received any prior or concurrent systemic therapy for RCC; adjuvant placebo administration is permitted
  • Patient must have no active peptic ulcer disease
  • Patient must have no active inflammatory bowel disease
  • Patient must have no New York Heart Association (NYHA) class II or greater congestive heart failure
  • Patient must have no prior history or current clinically apparent central nervous system metastases
  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at the time of randomization
  • Absolute granulocyte count > 1,500/mcL
  • Platelets > 100,000/mcL
  • Total bilirubin < 1.5 times institutional upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) < 2.5 times upper limit of normal (ULN)
  • Calculated creatinine clearance (CrCl) > 30 mL/min
  • Subjects must have a urine protein/creatinine (UPC) ratio < 1; if UPC >= 1, then a 24-hour urine total protein must be obtained; subjects must have a 24-hour urine protein value < 1g to be eligible; use of urine dipstick for renal function assessment is not acceptable
  • Women must not be pregnant or breast-feeding
  • Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately
  • Patient must be able to swallow pills and have no significant impairment in gastrointestinal absorption including history of gastric bypass surgery
  • Patient must have no history of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib
  • Patient must have no uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Patient must have a corrected QT (QTc) interval on electrocardiogram (ECG) =< 0.48 seconds by Bazett's calculation (=< Common Terminology Criteria for Adverse Events [CTCAE] v.4 Grade 2) prior to randomization
  • Patient must have a systolic blood pressure =< 140 mmHg and diastolic blood pressure must be =< 90 mmHg, measured within 4 weeks prior to randomization; initiation or adjustment of anti-hypertensives prior to starting study treatment is allowed
  • Patient must not have serious or non-healing wound, ulcer, or bone fracture at the time of randomization
  • Patient must have no history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 4 weeks prior to randomization
  • Patient must have no history of cerebrovascular accident (CVA) within 6 months of randomization
  • Patient must have no history of myocardial infarction, hospital admission for unstable angina, cardiac angioplasty or stenting within 6 months of randomization
  • Patient must have no history of venous thrombosis within 12 weeks of randomization
  • Patient cannot be taking strong CYP3A4 inhibitors such as:

    • Antibiotics: clarithromycin, telithromycin, troleandomycin
    • Human immunodeficiency virus (HIV) antiviral protease inhibitors: ritonavir, indinavir, saquinavir, nelfinavir, amprenavir, lopinavir
    • Antifungals: itraconazole, ketoconazole, voriconazole, fluconazole
    • Antidepressants: nefazodone
  • Patient must not have history of hemoptysis in excess of 2.5 mL (1/2 teaspoon) within 8 weeks prior to randomization
  • Patient must not be taking drugs known to prolong the QTc interval; such drugs should be discontinued at least 5 half-lives prior to randomization
  • Patients must not have any history of other cancer within 3 years from time of randomization with the exception of basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast, or resected non-invasive (Ta) urothelial carcinoma
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01575548

  Hide Study Locations
Locations
United States, Arizona
Arizona Cancer Center at UMC Orange Grove Withdrawn
Tucson, Arizona, United States, 85704
Arizona Cancer Center at University Medical Center North Withdrawn
Tucson, Arizona, United States, 85719
University of Arizona Health Sciences Center Withdrawn
Tucson, Arizona, United States, 85724
United States, California
City of Hope Recruiting
Duarte, California, United States, 91010
Contact: Sumanta K. Pal    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Sumanta K. Pal         
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: Frederick E. Millard    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: Frederick E. Millard         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: David I. Quinn    323-865-0451      
Principal Investigator: David I. Quinn         
University of Southern California/Norris Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: David I. Quinn    323-865-0451      
Principal Investigator: David I. Quinn         
United States, Connecticut
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Delaware Clinical and Laboratory Physicians PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Gynecologic Oncology LLC Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Nanticoke Memorial Hospital Recruiting
Seaford, Delaware, United States, 19973
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Wilmington Hospital Recruiting
Wilmington, Delaware, United States, 19801
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, District of Columbia
Lombardi Comprehensive Cancer Center at Georgetown University Recruiting
Washington, District of Columbia, United States, 20057
Contact: Nancy A. Dawson    202-444-0381      
Principal Investigator: Nancy A. Dawson         
United States, Georgia
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Wayne B. Harris    404-778-1868      
Principal Investigator: Wayne B. Harris         
Saint Joseph's Hospital of Atlanta Recruiting
Atlanta, Georgia, United States, 30342
Contact: Wayne B. Harris    404-778-1868      
Principal Investigator: Wayne B. Harris         
John B Amos Cancer Center Recruiting
Columbus, Georgia, United States, 31904
Contact: Andrew W. Pippas    706-660-6404      
Principal Investigator: Andrew W. Pippas         
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Richard J. LoCicero    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Richard J. LoCicero         
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Grant C. Lewis    912-350-8568      
Principal Investigator: Grant C. Lewis         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Saint Joseph Regional Medical Center Recruiting
Lewiston, Idaho, United States, 83501
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Idaho Urologic Institute-Meredian Active, not recruiting
Meridian, Idaho, United States, 83642
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Rush - Copley Medical Center Recruiting
Aurora, Illinois, United States, 60504
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Saint Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Hematology and Oncology Associates Terminated
Chicago, Illinois, United States, 60611
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Resurrection Healthcare Recruiting
Chicago, Illinois, United States, 60631
Contact: Christopher G. Rose    773-792-5116      
Principal Investigator: Christopher G. Rose         
Carle on Vermilion Recruiting
Danville, Illinois, United States, 61832
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Carle Physician Group-Effingham Recruiting
Effingham, Illinois, United States, 62401
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Western Illinois Cancer Treatment Center Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Hematology Oncology Associates of Illinois-Highland Park Recruiting
Highland Park, Illinois, United States, 60035
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Presence Saint Mary's Hospital Recruiting
Kankakee, Illinois, United States, 60901
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
North Shore Hematology Oncology Recruiting
Libertyville, Illinois, United States, 60048
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Carle Physician Group-Mattoon/Charleston Recruiting
Mattoon, Illinois, United States, 61938
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Joseph I. Clark    708-226-4357      
Principal Investigator: Joseph I. Clark         
Holy Family Medical Center Terminated
Monmouth, Illinois, United States, 61462
Illinois CancerCare-Monmouth Terminated
Monmouth, Illinois, United States, 61462
Good Samaritan Regional Health Center Withdrawn
Mount Vernon, Illinois, United States, 62864
Illinois Cancer Specialists-Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Community Cancer Center Foundation Terminated
Normal, Illinois, United States, 61761
Radiation Oncology of Northern Illinois Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Ottawa Regional Hospital and Healthcare Center Active, not recruiting
Ottawa, Illinois, United States, 61350
Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Proctor Hospital Terminated
Peoria, Illinois, United States, 61614
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Terminated
Peoria, Illinois, United States, 61615
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC Recruiting
Peoria, Illinois, United States, 61615-7827
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Valley Hospital Terminated
Peru, Illinois, United States, 61354
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Valley Radiation Oncology Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Hematology Oncology Associates of Illinois - Skokie Recruiting
Skokie, Illinois, United States, 60076
Contact: Timothy M. Kuzel    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Timothy M. Kuzel         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
The Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Rush-Copley Healthcare Center Recruiting
Yorkville, Illinois, United States, 60560
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
United States, Indiana
Franciscan Saint Francis Health-Indianapolis Active, not recruiting
Indianapolis, Indiana, United States, 46237
Indiana University Medical Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Theodore F. Logan    317-274-2552      
Principal Investigator: Theodore F. Logan         
Woodland Cancer Care Center Recruiting
Michigan City, Indiana, United States, 46360
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Franciscan Saint Anthony Health-Michigan City Recruiting
Michigan City, Indiana, United States, 46360
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
Memorial Regional Cancer Center Day Road Recruiting
Mishawaka, Indiana, United States, 46544
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
Reid Hospital and Health Care Services Recruiting
Richmond, Indiana, United States, 47374
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mary Greeley Medical Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Boone Recruiting
Boone, Iowa, United States, 50036
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Trinity Cancer Center Recruiting
Fort Dodge, Iowa, United States, 50501
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Daniel A. Vaena    800-237-1225      
Principal Investigator: Daniel A. Vaena         
McFarland Clinic PC-Jefferson Recruiting
Jefferson, Iowa, United States, 50129
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Marshalltown Recruiting
Marshalltown, Iowa, United States, 50158
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mercy Medical Center - North Iowa Recruiting
Mason City, Iowa, United States, 50401
Contact: Arvind Y. Vemula    800-433-3883      
Principal Investigator: Arvind Y. Vemula         
Mercy Medical Center-Sioux City Terminated
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Saint Luke's Regional Medical Center Terminated
Sioux City, Iowa, United States, 51104
United States, Kansas
Newman Regional Health Active, not recruiting
Emporia, Kansas, United States, 66801
Saint Catherine Hospital Active, not recruiting
Garden City, Kansas, United States, 67846
Saint Rose Ambulatory and Surgery Center Active, not recruiting
Great Bend, Kansas, United States, 67530
Hays Medical Center Active, not recruiting
Hays, Kansas, United States, 67601
Kansas City Cancer Center-West Active, not recruiting
Kansas City, Kansas, United States, 66112
University of Kansas Medical Center Active, not recruiting
Kansas City, Kansas, United States, 66160
Kansas City Cancer Centers-Southwest Active, not recruiting
Overland Park, Kansas, United States, 66210
Via Christi Hospital-Pittsburg Active, not recruiting
Pittsburg, Kansas, United States, 66762
Salina Regional Health Center Active, not recruiting
Salina, Kansas, United States, 67401
Saint Francis Hospital and Medical Center - Topeka Active, not recruiting
Topeka, Kansas, United States, 66606
Stormont-Vail Regional Health Center Recruiting
Topeka, Kansas, United States, 66604
Contact: David E. Einspahr    785-270-4963      
Principal Investigator: David E. Einspahr         
United States, Kentucky
Oncology Hematology Care Inc-Crestview Recruiting
Crestview Hills, Kentucky, United States, 41017
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
United States, Louisiana
Robert Veith MD LLC Recruiting
Metairie, Louisiana, United States, 70006
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
East Jefferson General Hospital Recruiting
Metairie, Louisiana, United States, 70006
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
Louisiana State University Health Science Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
Interim LSU Public Hospital Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
United States, Maryland
Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Recruiting
Baltimore, Maryland, United States, 21287
Contact: Jenny J. Kim    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Jenny J. Kim         
Union Hospital of Cecil County Recruiting
Elkton MD, Maryland, United States, 21921
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
University of Michigan Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Ajjai S. Alva    800-865-1125    burton@bcm.edu   
Principal Investigator: Ajjai S. Alva         
Michigan Cancer Research Consortium Community Clinical Oncology Program Terminated
Ann Arbor, Michigan, United States, 48106
University of Michigan University Hospital Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Leonard J. Appleman    412-647-8073    applemanlj@upmc.edu   
Principal Investigator: Leonard J. Appleman         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Spectrum Health Big Rapids Hospital Terminated
Big Rapids, Michigan, United States, 49307
Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48124
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48502
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Grand Rapids Clinical Oncology Program Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Sunil Nagpal    269-373-7458      
Principal Investigator: Sunil Nagpal         
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Lakeland Community Hospital Recruiting
Niles, Michigan, United States, 49120
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Lakeland Hospital Recruiting
St. Joseph, Michigan, United States, 49085
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella    734-712-4673      
Principal Investigator: Philip J. Stella         
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Brian A. Costello    507-538-7623      
Principal Investigator: Brian A. Costello         
Coborn Cancer Center at Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
United States, Mississippi
University of Mississippi Medical Center Active, not recruiting
Jackson, Mississippi, United States, 39216
United States, Missouri
Parkland Health Center-Bonne Terre Recruiting
Bonne Terre, Missouri, United States, 63628
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
Southeast Cancer Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Saint Luke's Hospital Recruiting
Chesterfield, Missouri, United States, 63017
Contact: Donald F. Busiek    314-205-6936      
Principal Investigator: Donald F. Busiek         
Capital Region Medical Center-Goldschmidt Cancer Center Recruiting
Jefferson City, Missouri, United States, 65109
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Kansas City Cancer Centers - North Active, not recruiting
Kansas City, Missouri, United States, 64154
Truman Medical Center Active, not recruiting
Kansas City, Missouri, United States, 64108
Kansas City Cancer Center - South Active, not recruiting
Kansas City, Missouri, United States, 64131
Kansas City Cancer Center-Lee's Summit Active, not recruiting
Lee's Summit, Missouri, United States, 64064
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
Saint Louis-Cape Girardeau CCOP Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
Saint Louis Cancer and Breast Institute-South City Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Joel Picus    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Joel Picus         
Sainte Genevieve County Memorial Hospital Recruiting
Sainte Genevieve, Missouri, United States, 63670
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Missouri Baptist Sullivan Hospital Recruiting
Sullivan, Missouri, United States, 63080
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Missouri Baptist Outpatient Center-Sunset Hills Recruiting
Sunset Hills, Missouri, United States, 63127
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
United States, Montana
Montana Cancer Consortium CCOP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Hematology-Oncology Centers of the Northern Rockies PC Terminated
Billings, Montana, United States, 59102
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Cancer Center Withdrawn
Bozeman, Montana, United States, 59715
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Medical Oncology Terminated
Kalispell, Montana, United States, 59901
Montana Cancer Specialists Terminated
Missoula, Montana, United States, 59802
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Ralph J. Hauke    402-354-5144      
Principal Investigator: Ralph J. Hauke         
United States, Nevada
Cancer and Blood Specialists-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology - Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Southeast Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology - Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Shadow Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Children's Specialty Center of Nevada II Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Central Valley Recruiting
Las Vegas, Nevada, United States, 89169
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer Therapy and Integrative Medicine Recruiting
Las Vegas, Nevada, United States, 89121
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Northwest Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology - Vegas Tenaya Recruiting
Las Vegas, Nevada, United States, 89182
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Summerlin Recruiting
Las Vegas, Nevada, United States, 89144
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Recruiting
Las Vegas, Nevada, United States, 89149
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-San Martin Recruiting
Las Vegas, Nevada, United States, 89113
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Summerlin Hospital Medical Center Recruiting
Las Vegas, Nevada, United States, 89144
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Medical Center Recruiting
Las Vegas, Nevada, United States, 89148-2405
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Nevada Cancer Research Foundation CCOP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Southeast Recruiting
Las Vegas, Nevada, United States, 89119
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology - Vegas Sunrise Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
United States, New Jersey
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Rutgers Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Eric A. Singer    732-235-8675      
Principal Investigator: Eric A. Singer         
United States, New York
Montefiore Medical Center-Einstein Campus Recruiting
Bronx, New York, United States, 10461
Contact: Benjamin A. Gartrell    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Benjamin A. Gartrell         
Montefiore Medical Center - Moses Campus Recruiting
Bronx, New York, United States, 10467-2490
Contact: Benjamin A. Gartrell    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Benjamin A. Gartrell         
Albert Einstein College of Medicine Recruiting
Bronx, New York, United States, 10461
Contact: Benjamin A. Gartrell    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Benjamin A. Gartrell         
Orange Regional Medical Center Recruiting
Middletown, New York, United States, 10940
Contact: Jeffrey M. Stewart    845-342-7609      
Principal Investigator: Jeffrey M. Stewart         
United States, North Carolina
Randolph Hospital Recruiting
Asheboro, North Carolina, United States, 27203
Contact: James M. Granfortuna    336-832-0821      
Principal Investigator: James M. Granfortuna         
Duke University Medical Center Withdrawn
Durham, North Carolina, United States, 27710
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Cone Health Cancer Center Recruiting
Greensboro, North Carolina, United States, 27403
Contact: James M. Granfortuna    336-832-0821      
Principal Investigator: James M. Granfortuna         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Annie Penn Memorial Hospital Recruiting
Reidsville, North Carolina, United States, 27320
Contact: James M. Granfortuna    336-832-0821      
Principal Investigator: James M. Granfortuna         
United States, Ohio
Strecker Cancer Center-Belpre Recruiting
Belpre, Ohio, United States, 45714
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Oncology Hematology Care Inc-Blue Ash Recruiting
Cincinnati, Ohio, United States, 45242
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc-Mercy West Recruiting
Cincinnati, Ohio, United States, 45211
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Kenwood Recruiting
Cincinnati, Ohio, United States, 45236
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology and Hematology Care Inc-Taft Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Anderson Recruiting
Cincinnati, Ohio, United States, 45230
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Columbus Oncology and Hematology Associates Inc Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Doctors Hospital Recruiting
Columbus, Ohio, United States, 43228
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus CCOP Terminated
Columbus, Ohio, United States, 43215
Samaritan North Health Center Recruiting
Dayton, Ohio, United States, 45415
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Grandview Hospital Active, not recruiting
Dayton, Ohio, United States, 45405
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Dayton CCOP Terminated
Dayton, Ohio, United States, 45420
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Delaware Radiation Oncology Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Delaware Health Center-Grady Cancer Center Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Oncology Hematology Care Inc-Healthplex Recruiting
Fairfield, Ohio, United States, 45014
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Blanchard Valley Hospital Recruiting
Findlay, Ohio, United States, 45840
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Atrium Medical Center-Middletown Regional Hospital Recruiting
Franklin, Ohio, United States, 45005-1066
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Wayne Hospital Recruiting
Greenville, Ohio, United States, 45331
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Lancaster Radiation Oncology Terminated
Lancaster, Ohio, United States, 43130
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Newark Radiation Oncology Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Trinity's Tony Teramana Cancer Center Recruiting
Steubenville, Ohio, United States, 43952
Contact: Leonard J. Appleman    412-647-8073      
Principal Investigator: Leonard J. Appleman         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Greene Memorial Hospital Terminated
Xenia, Ohio, United States, 45385
Genesis HealthCare System Recruiting
Zanesville, Ohio, United States, 43701
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
United States, Oklahoma
Cancer Centers of Southwest Oklahoma Research Recruiting
Lawton, Oklahoma, United States, 73505
Contact: Nadim F. Nimeh    877-231-4440      
Principal Investigator: Nadim F. Nimeh         
Cancer Care Associates-Norman Recruiting
Norman, Oklahoma, United States, 73071
Contact: Vikki A. Canfield    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Vikki A. Canfield         
Cancer Care Associates-Mercy Recruiting
Oklahoma City, Oklahoma, United States, 73120
Contact: Vikki A. Canfield    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Vikki A. Canfield         
Natalie Warren Bryant Cancer Center at Saint Francis Withdrawn
Tulsa, Oklahoma, United States, 74136
Warren Cancer Research Foundation Terminated
Tulsa, Oklahoma, United States, 74136
Oklahoma Oncology Inc Terminated
Tulsa, Oklahoma, United States, 74104
United States, Oregon
Three Rivers Community Hospital Recruiting
Grants Pass, Oregon, United States, 97527
Contact: Charles R. Dibb    541-789-6176      
Principal Investigator: Charles R. Dibb         
Rogue Valley Medical Center Recruiting
Medford, Oregon, United States, 97504
Contact: Charles R. Dibb    541-789-6176      
Principal Investigator: Charles R. Dibb         
Providence Medford Medical Center Recruiting
Medford, Oregon, United States, 97504
Contact: Charles R. Dibb    541-789-6176      
Principal Investigator: Charles R. Dibb         
Oregon Health and Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Christopher W. Ryan    503-494-1080    trials@ohsu.edu   
Principal Investigator: Christopher W. Ryan         
United States, Pennsylvania
Lehigh Valley Hospital Recruiting
Allentown, Pennsylvania, United States, 18105
Contact: Eliot L. Friedman    610-402-2273      
Principal Investigator: Eliot L. Friedman         
Lehigh Valley Hospital - Muhlenberg Recruiting
Bethlehem, Pennsylvania, United States, 18017
Contact: Eliot L. Friedman    610-402-2273      
Principal Investigator: Eliot L. Friedman         
University of Pennsylvania/Abramson Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Naomi S. Balzer-Haas    800-474-9892      
Principal Investigator: Naomi S. Balzer-Haas         
University of Pittsburgh Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Leonard J. Appleman    412-647-8073      
Principal Investigator: Leonard J. Appleman         
University of Pittsburgh Cancer Institute Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Leonard J. Appleman    412-648-6507    applemanlj@upmc.edu   
Principal Investigator: Leonard J. Appleman         
Pottstown Memorial Medical Center Recruiting
Pottstown, Pennsylvania, United States, 19464
Contact: Wei F. Song    610-327-7544      
Principal Investigator: Wei F. Song         
United States, South Carolina
Roper Hospital Recruiting
Charleston, South Carolina, United States, 29401
Contact: James M. Orcutt    843-720-8386    elizabeth.strojny@roperstfrancis.com   
Principal Investigator: James M. Orcutt         
McLeod Regional Medical Center Active, not recruiting
Florence, South Carolina, United States, 29506
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Mark T. Schroeder    605-716-3982    research@rcrh.org   
Principal Investigator: Mark T. Schroeder         
United States, Tennessee
Wellmont Bristol Regional Medical Center Active, not recruiting
Bristol, Tennessee, United States, 37620
Wellmont Medical Associates Oncology and Hematology-Bristol Recruiting
Bristol, Tennessee, United States, 37620
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Erlanger Medical Center Recruiting
Chattanooga, Tennessee, United States, 37403
Contact: Larry L. Schlabach    423-778-6947      
Principal Investigator: Larry L. Schlabach         
Wellmont Holston Valley Hospital and Medical Center Recruiting
Kingsport, Tennessee, United States, 37660
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Wellmont Medical Associates Oncology and Hematology-Kingsport Recruiting
Kingsport, Tennessee, United States, 37660
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
University of Tennessee - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Wahid T. Hanna    865-544-9773      
Principal Investigator: Wahid T. Hanna         
United States, Utah
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Junfeng Wang    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Junfeng Wang         
United States, Virginia
Bon Secours Saint Francis Medical Center Recruiting
Midlothian, Virginia, United States, 23114
Contact: William J. Irvin    804-594-4900      
Principal Investigator: William J. Irvin         
Southwest VA Regional Cancer Center Recruiting
Norton, Virginia, United States, 24273
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Bon Secours Saint Mary's Hospital Recruiting
Richmond, Virginia, United States, 23226
Contact: William J. Irvin    804-594-4900      
Principal Investigator: William J. Irvin         
United States, Washington
Auburn Regional Medical Center Recruiting
Auburn, Washington, United States, 98001
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Overlake Hospital Medical Center Recruiting
Bellevue, Washington, United States, 98004
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Providence Regional Cancer System-Centralia Recruiting
Centralia, Washington, United States, 98531
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Providence Regional Cancer Partnership Recruiting
Everett, Washington, United States, 98201
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Saint Francis Hospital Active, not recruiting
Federal Way, Washington, United States, 98003
Providence Regional Cancer System-Lacey Active, not recruiting
Lacey, Washington, United States, 98503
Saint Clare Hospital Recruiting
Lakewood, Washington, United States, 98499
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Capital Medical Center Terminated
Olympia, Washington, United States, 98507
Providence - Saint Peter Hospital Terminated
Olympia, Washington, United States, 98506-5166
Good Samaritan Community Hospital Recruiting
Puyallup, Washington, United States, 98372
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Northwest CCOP Terminated
Tacoma, Washington, United States, 98405
Northwest Medical Specialties PLLC Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Allenmore Hospital Terminated
Tacoma, Washington, United States, 98405
Saint Joseph Medical Center Terminated
Tacoma, Washington, United States, 98405
Multicare Health System Recruiting
Tacoma, Washington, United States, 98415
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
United States, West Virginia
West Virginia University Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer    304-344-3457      
Principal Investigator: Steven J. Jubelirer         
Princeton Community Hospital Recruiting
Princeton, West Virginia, United States, 24740
Contact: Rowena Gonzales-Chambers    304-487-7000      
Principal Investigator: Rowena Gonzales-Chambers         
United States, Wisconsin
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
Wheaton Franciscan Healthcare - Saint Joseph Recruiting
Milwaukee, Wisconsin, United States, 53210
Contact: Jonathan S. Treisman    414-427-2360      
Principal Investigator: Jonathan S. Treisman         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Kathryn A. Bylow    414-805-4380      
Principal Investigator: Kathryn A. Bylow         
D N Greenwald Center Recruiting
Mukwonago, Wisconsin, United States, 53149
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Waukesha Memorial Hospital - ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
United States, Wyoming
Rocky Mountain Oncology Terminated
Casper, Wyoming, United States, 82609
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Sponsors and Collaborators
Investigators
Principal Investigator: Leonard Appleman Eastern Cooperative Oncology Group
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01575548     History of Changes
Other Study ID Numbers: NCI-2012-00723, NCI-2012-00723, CDR0000730383, ECOG-E2810, E2810, E2810, U10CA021115, U10CA180820
Study First Received: April 10, 2012
Last Updated: October 17, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Carcinoma, Renal Cell
Carcinoma
Adenocarcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Kidney Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on October 19, 2014