Post Marketing Surveillance of Mirapex LA on the Long-term Use

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Boehringer Ingelheim Pharmaceuticals
ClinicalTrials.gov Identifier:
NCT01525641
First received: February 1, 2012
Last updated: May 2, 2013
Last verified: May 2013
  Purpose

In Japan, post-approval execution of post-marketing surveillance (PMS) is requested by the Japanese Pharmaceutical Affairs Law (J-PAL) in order to accumulate safety and efficacy data for re-examination. Reexamination period is defined by the J-PAL Four years after approval of new dosage form, results of PMS need to be submitted as a part of re-examination dossier to the Japanese regulatory authority, the Ministry of Health, Labour and Welfare.


Condition Intervention
Parkinson Disease
Drug: Mirapex LA

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Post Marketing Survey on Long Term Drug Use of Mirapex LA Tablets in Patients With Parkinson's Disease

Resource links provided by NLM:


Further study details as provided by Boehringer Ingelheim Pharmaceuticals:

Primary Outcome Measures:
  • Proportion of adverse drug reactions [ Time Frame: up to 52 weeks ] [ Designated as safety issue: Yes ]
  • Proportion of serious adverse events [ Time Frame: up to 52 weeks ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Clinical global impression of effect [ Time Frame: up to 52 weeks ]
  • Change from baseline in total score of the UPDRS Part III to last observation [ Time Frame: up to 52 weeks ]
  • Change from baseline in the Modified Hoehn & Yahr to last observation [ Time Frame: up to 52 weeks ]
  • Proportion of following AEs of special interest -Sudden onset of sleep -Somnolence -Neuroleptic malignant syndrome -Hallucination -Delusion -Delirium -Agitation -Confusion -Dyspepsia -Dry mouth -Constipation -Vomiting -Abnormal behaviour [ Time Frame: up to 52 weeks ] [ Designated as safety issue: Yes ]
  • Onset or offset of on and off/wearing-off phenomenon in patients with concomitant L-DOPA [ Time Frame: up to 52 weeks ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 600
Study Start Date: February 2012
Estimated Study Completion Date: February 2014
Estimated Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patient with Parkinson's Disease Drug: Mirapex LA
Pramipexole Hydrochloride Hydrate

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

600

Criteria

Inclusion criteria:

- Patients with Parkinson's disease who have never been treated with Mirapex LA Tablets before enrolment will be included.

Exclusion criteria:

- None

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01525641

  Hide Study Locations
Locations
Japan
Boehringer Ingelheim Investigational Site 28
Abiko,Chiba, Japan
Boehringer Ingelheim Investigational Site 86
Akashi,Hyogo, Japan
Boehringer Ingelheim Investigational Site 13
Akita,Akita, Japan
Boehringer Ingelheim Investigational Site 9
Aomori,Aomori, Japan
Boehringer Ingelheim Investigational Site 2
Asahikawa,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 36
Bunkyo,Tokyo, Japan
Boehringer Ingelheim Investigational Site 35
Chuo,Tokyo, Japan
Boehringer Ingelheim Investigational Site 40
Chuo,Tokyo, Japan
Boehringer Ingelheim Investigational Site 54
Chuo,Yamanashi, Japan
Boehringer Ingelheim Investigational Site 6
Date,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 34
Edogawa,Tokyo, Japan
Boehringer Ingelheim Investigational Site 32
Fuchu,Tokyo, Japan
Boehringer Ingelheim Investigational Site 22
Fujioka,Gunma, Japan
Boehringer Ingelheim Investigational Site 48
Fujisawa,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 46
Fujisawa,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 24
Fukaya,Saitama, Japan
Boehringer Ingelheim Investigational Site 53
Fukui,Fukui, Japan
Boehringer Ingelheim Investigational Site 105
Fukuoka,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 106
Fukuoka,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 109
Fukuoka,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 16
Fukushima,Fukushima, Japan
Boehringer Ingelheim Investigational Site 60
Gifu,Gifu, Japan
Boehringer Ingelheim Investigational Site 44
Hadano,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 62
Hamamatsu,Shizuoka, Japan
Boehringer Ingelheim Investigational Site 97
Hiroshima,Hiroshima, Japan
Boehringer Ingelheim Investigational Site 96
Hiroshima,Hiroshima, Japan
Boehringer Ingelheim Investigational Site 78
Ibaraki,Osaka, Japan
Boehringer Ingelheim Investigational Site 29
Ichihara,Chiba, Japan
Boehringer Ingelheim Investigational Site 68
Ichinomiya,Aichi, Japan
Boehringer Ingelheim Investigational Site 57
Iida,Nagano, Japan
Boehringer Ingelheim Investigational Site 108
Iiduka,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 88
Ikoma,Nara, Japan
Boehringer Ingelheim Investigational Site 103
Imabari,Ehime, Japan
Boehringer Ingelheim Investigational Site 17
Iwaki,Fukushima, Japan
Boehringer Ingelheim Investigational Site 3
Iwamizawa,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 117
Kirishima,Kagoshima, Japan
Boehringer Ingelheim Investigational Site 111
Kitakyushu,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 5
Kitami,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 55
Kofu,Yamanashi, Japan
Boehringer Ingelheim Investigational Site 70
Konan,Aichi, Japan
Boehringer Ingelheim Investigational Site 27
Koshigaya,Saitama, Japan
Boehringer Ingelheim Investigational Site 114
Kumamoto,Kumamoto, Japan
Boehringer Ingelheim Investigational Site 107
Kurume,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 77
Kyoto,Kyoto, Japan
Boehringer Ingelheim Investigational Site 23
Maebashi,Gunma, Japan
Boehringer Ingelheim Investigational Site 42
Minato,Tokyo, Japan
Boehringer Ingelheim Investigational Site 116
Miyakonojo,Miyazaki, Japan
Boehringer Ingelheim Investigational Site 66
Miyoshi,Aichi, Japan
Boehringer Ingelheim Investigational Site 10
Morioka,Iwate, Japan
Boehringer Ingelheim Investigational Site 74
Moriyama,Shiga, Japan
Boehringer Ingelheim Investigational Site 4
Muroran,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 56
Nagano,Nagano, Japan
Boehringer Ingelheim Investigational Site 30
Nagareyama,Chiba, Japan
Boehringer Ingelheim Investigational Site 113
Nagasaki,Nagasaki, Japan
Boehringer Ingelheim Investigational Site 67
Nagoya,Aichi, Japan
Boehringer Ingelheim Investigational Site 65
Nagoya,Aichi, Japan
Boehringer Ingelheim Investigational Site 52
Nanao,Ishikawa, Japan
Boehringer Ingelheim Investigational Site 104
Nangoku,Kouchi, Japan
Boehringer Ingelheim Investigational Site 50
Niigata,Niigata, Japan
Boehringer Ingelheim Investigational Site 85
Nishinomiya,Hyogo, Japan
Boehringer Ingelheim Investigational Site 72
Obu,Aichi, Japan
Boehringer Ingelheim Investigational Site 61
Ogaki,Gifu, Japan
Boehringer Ingelheim Investigational Site 92
Ohta,Shimane, Japan
Boehringer Ingelheim Investigational Site 115
Oita,Oita, Japan
Boehringer Ingelheim Investigational Site 95
Okayama,Okayama, Japan
Boehringer Ingelheim Investigational Site 93
Okayama,Okayama, Japan
Boehringer Ingelheim Investigational Site 118
Okinawa,Okinawa, Japan
Boehringer Ingelheim Investigational Site 110
Onojo,Fukuoka, Japan
Boehringer Ingelheim Investigational Site 82
Osaka,Osaka, Japan
Boehringer Ingelheim Investigational Site 80
Osaka,Osaka, Japan
Boehringer Ingelheim Investigational Site 81
Osaka,Osaka, Japan
Boehringer Ingelheim Investigational Site 38
Ota,Tokyo, Japan
Boehringer Ingelheim Investigational Site 75
Otsu,Shiga, Japan
Boehringer Ingelheim Investigational Site 76
Otsu,Shiga, Japan
Boehringer Ingelheim Investigational Site 18
Ryugasaki,Ibaragi, Japan
Boehringer Ingelheim Investigational Site 47
Sagamihara,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 43
Sagamihara,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 26
Saitama,Saitama, Japan
Boehringer Ingelheim Investigational Site 25
Saitama,Saitama, Japan
Boehringer Ingelheim Investigational Site 79
Sakai,Osaka, Japan
Boehringer Ingelheim Investigational Site 83
Sakai,Osaka, Japan
Boehringer Ingelheim Investigational Site 102
Sakaide,Kagawa, Japan
Boehringer Ingelheim Investigational Site 58
Saku,Nagano, Japan
Boehringer Ingelheim Investigational Site 31
Sakura,Chiba, Japan
Boehringer Ingelheim Investigational Site 98
Sanyo-Onoda, Japan
Boehringer Ingelheim Investigational Site 7
Sapporo,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 1
Sapporo,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 8
Sapporo,Hokkaido, Japan
Boehringer Ingelheim Investigational Site 59
Sekigahara,Gifu, Japan
Boehringer Ingelheim Investigational Site 11
Sendai,Miyagi, Japan
Boehringer Ingelheim Investigational Site 12
Sendai,Miyagi, Japan
Boehringer Ingelheim Investigational Site 33
Setagaya,Tokyo, Japan
Boehringer Ingelheim Investigational Site 69
Seto,Aichi, Japan
Boehringer Ingelheim Investigational Site 63
Shimoda,Shizuoka, Japan
Boehringer Ingelheim Investigational Site 64
Shimoda,Shizuoka, Japan
Boehringer Ingelheim Investigational Site 99
Shimonoseki,Yamaguchi, Japan
Boehringer Ingelheim Investigational Site 20
Shimotsuke,Tochigi, Japan
Boehringer Ingelheim Investigational Site 21
Shimotsuke,Tochigi, Japan
Boehringer Ingelheim Investigational Site 90
Shingu,Wakayama, Japan
Boehringer Ingelheim Investigational Site 37
Shinjuku,Tokyo, Japan
Boehringer Ingelheim Investigational Site 41
Shinjuku,Tokyo, Japan
Boehringer Ingelheim Investigational Site 39
Shinjuku,Tokyo, Japan
Boehringer Ingelheim Investigational Site 51
Takaoka,Toyama, Japan
Boehringer Ingelheim Investigational Site 101
Tokushima,Tokushima, Japan
Boehringer Ingelheim Investigational Site 112
Tosu,Saga, Japan
Boehringer Ingelheim Investigational Site 71
Toyokawa,Aichi, Japan
Boehringer Ingelheim Investigational Site 84
Toyonaka,Osaka, Japan
Boehringer Ingelheim Investigational Site 87
Toyooka,Hyogo, Japan
Boehringer Ingelheim Investigational Site 73
Tsu,Mie, Japan
Boehringer Ingelheim Investigational Site 19
Tsukuba,Ibaragi, Japan
Boehringer Ingelheim Investigational Site 94
Tsukubo,Okayama, Japan
Boehringer Ingelheim Investigational Site 15
Tsuruoka,Yamagata, Japan
Boehringer Ingelheim Investigational Site 89
Wakayama,Wakayama, Japan
Boehringer Ingelheim Investigational Site 91
Yazu,Tottori, Japan
Boehringer Ingelheim Investigational Site 45
Yokohama,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 49
Yokohama,Kanagawa, Japan
Boehringer Ingelheim Investigational Site 14
Yokote,Akita, Japan
Boehringer Ingelheim Investigational Site 100
Yoshinogawa,Tokushima, Japan
Sponsors and Collaborators
Boehringer Ingelheim Pharmaceuticals
Investigators
Study Chair: Boehringer Ingelheim Boehringer Ingelheim Pharmaceuticals
  More Information

No publications provided

Responsible Party: Boehringer Ingelheim Pharmaceuticals
ClinicalTrials.gov Identifier: NCT01525641     History of Changes
Other Study ID Numbers: 248.680
Study First Received: February 1, 2012
Last Updated: May 2, 2013
Health Authority: Japan: Ministry of Health, Labor and Welfare

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Pramipexol
Antioxidants
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protective Agents
Physiological Effects of Drugs
Antiparkinson Agents
Anti-Dyskinesia Agents
Central Nervous System Agents
Therapeutic Uses
Dopamine Agonists
Dopamine Agents
Neurotransmitter Agents

ClinicalTrials.gov processed this record on May 16, 2013