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| Sponsor: | Mayo Clinic |
|---|---|
| Information provided by (Responsible Party): | Sharonne Hayes, Mayo Clinic |
| ClinicalTrials.gov Identifier: | NCT01427179 |
Purpose
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.
Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.
| Condition |
|---|
|
Spontaneous Coronary Artery Dissection SCAD |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based |
| Official Title: | Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD) |
A 30 ml sample of blood from a vein or an existing catheter will be drawn at Mayo Clinic or another medical center and returned through the mail in a kit. An additional 10 ml (2 teaspoons) of blood, buccal smear, and/or available tissue samples may also be collected.
| Estimated Enrollment: | 600 |
| Study Start Date: | May 2011 |
| Estimated Study Completion Date: | December 2013 |
Study question: Do mutations within certain genes cause or confer susceptibility to spontaneous coronary artery dissection (SCAD)?
Specific aims:
Long term objective:Discover molecular and cellular mechanisms of SCAD and develop biomarkers to enable prediction and prevention.
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause tears in blood vessels that supply the heart. Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person. The study includes individuals diagnosed with spontaneous coronary artery dissection and their biological parents.
Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood sample procurement.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Men and women diagnosed with spontaneous coronary artery dissection (SCAD) or and their biological parents.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Dawn Shelstad | 507-255-0473 | MayoSCAD@Mayo.edu |
| Contact: Dawn Shelstad | 507-255-0473 | shelstad.dawn@mayo.edu |
| United States, Minnesota | |
| Mayo Clinic | Recruiting |
| Rochester, Minnesota, United States, 55905 | |
| Contact: Dawn J. Shelstad 507-255-0473 mayoscad@mayo.edu | |
| Contact: Dawn j. Shelstad 507-255-0473 shelstad.dawn@mayo.edu | |
| Principal Investigator: Timothy M. Olson, M.D. | |
| Principal Investigator: Sharonne N. Hayes, M.D. | |
| Principal Investigator: | Timothy M. Olson, M.D. | Mayo Clinic |
| Principal Investigator: | Sharonne N. Hayes, M.D. | Mayo Clinic |
More Information
| Responsible Party: | Sharonne Hayes, Associate Professor, Cardiovascular Diseases, Mayo Clinic |
| ClinicalTrials.gov Identifier: | NCT01427179 History of Changes |
| Other Study ID Numbers: | 11-000160 |
| Study First Received: | August 30, 2011 |
| Last Updated: | February 10, 2012 |
| Health Authority: | United States: Institutional Review Board |
|
Spontaneous coronary artery dissection SCAD |
|
Aneurysm, Dissecting Aneurysm Vascular Diseases Cardiovascular Diseases |
