Brain Areas Involved in Sound and Spoken Word Memory
- Studies have shown that animals such as monkeys and dogs have excellent sight and touch memory but perform poorly on sound memory tasks. Human brains have certain areas that are important for speaking and understanding language. These areas may be involved in sound and spoken word memory. Researchers want to study these areas of the brain to find out if the memory for sounds requires brain structures that are usually associated with language learning and are unique to humans.
- To use magnetic resonance imaging to study areas of the brain involved in sound memory.
- Healthy right-handed volunteers between 18 and 50 years of age. They must be native English speakers and have completed high school.
- The study requires a screening visit and 1 or 2 study visits to the National Institutes of Health Clinical Center.
- At the screening visit, volunteers will have a medical history taken. They will also have physical and neurological exams, and complete a questionnaire. Women of childbearing age will give a urine sample. Participants who have not had a magnetic resonance imaging (MRI) scan in the past year will have one at this visit.
- At the second visit, participants will have tests of sound memory. They will listen to a set of nonsense words spoken through earphones and memorize the words. Then they will listen to the words again to judge if the words were part of the earlier list. Participants will have a 1 hour break, then do the sound memory test again. During the second test they will have repetitive transcranial magnetic stimulation (rTMS), which stimulates different regions of the brain.
- If the group results from the testing sessions are positive, there will be a third visit. At this visit, participants will have a sound perception test. They will listen to words spoken through earphones and judge whether the words in the pair are the same or different. Participants will have rTMS during these tests as well.
|Study Design:||Time Perspective: Prospective|
|Official Title:||The Role of the Inferior Frontal Gyrus in Long-Term Auditory Memory a rTMS Study|
- The primary outcome of this study is the error rate during the recognition memory task. The error rate is defined by the amount of stimuli that are correctly classified as familiar or unfamiliar.
- The secondary outcome measure of this study is the reaction time of participants to make judgments concerning the familiarity during the recognition memory task.
|Study Start Date:||May 2011|
Humans are the only animals that use language to communicate with each other. Among many other requirements, humans need excellent auditory long-term memory to be able to master the complicated task of learning a language. It is still not completely understood which brain regions are involved in transferring auditory stimuli into long-term memory. The goal of this research proposal is to examine whether brain structures that are known to be essential in language production also play an important role in encoding auditory stimuli into long-term memory.
We intend to study 15 adult healthy volunteers on an outpatient basis for each of three sub-experiments (maximum: 3 experiments with 15 people = 45). By amendment, 15 additional subjects will be recruited to re-run experiment one. This brings the accrual to 60 healthy volunteers.
We propose using repetitive transcranial magnetic stimulation (rTMS) to examine the role of frontal and temporo-parietal cortical areas in the storage of auditory stimuli in long-term memory. The whole study can comprise up to three experiments (depending on the results of each experiment). Each of the three experiments will consist of one to three sessions. Session 1 can be skipped if the participant already has had a neuro-exam and an MRI scan at the NIH, and does not need a pregnancy test. In that case consenting will be done at the beginning of session 2. Session 2 will be compulsory in every experiment. Session 3 will only be required if positive results are obtained in session 2. Every participant can only participate in one of the three planned experiments.
In Experiment 1, we will investigate the potential role of Broca s area in auditory memory. If we find that rTMS in Broca s area interferes with performance on the memory task, we will conduct a control (session 3) to determine whether or not the impairment was actually due to interference with stimulus perception rather than with memory, per se. If we find that stimulating Broca's area interferes with auditory memory (significant effect in session 2) but does not impair stimulus perception per se (no significant effect in session 3) we will not test any additional stimulation sites. If we fail to find a contribution from Broca s area, or if stimulation impairs stimulus perception as well as memory, we will conduct Experiment 2 to investigate the possible role of Wernicke s region in auditory memory. If we find a significant effect on auditory memory (as in Experiment 1) we will not investigate further, if we fail to find an effect we will conduct Experiment 3 to investigate the role of the ventral premotor cortex (PMv) in auditory memory.
In experiment 2 and 3 we will also conduct the same control session 3, as in Experiment 1 if the rTMS impairs performance on the auditory memory task. All experiments will consist of two sessions and an additional, third session if rTMS-induced impairment is found. In that case all participants will be called back for the control experiment. During session 1, a neurological examination will be performed and a clinical and anatomical MRI (Magnetic Resonance Imaging) will be taken. Session 1 can be omitted if an MRI and a neurological exam were performed at the NIH during the past year. In session 2, rTMS will be used in an attempt to temporarily disrupt the function of Broca s area (experiment 1), PMv (experiment 2) or the TPJ (experiment 3) while participants are performing an auditory recognition memory task. By temporarily disrupting cortical functioning in those localized regions, we will be able to determine whether or not their function is crucial for encoding auditory stimuli into long-term memory. In the control session, to be conducted only if the experimental task yields a positive result (i.e., impairment), we will test auditory perception by asking participants to make same/different judgments on stimulus pairs (similar to those used in session 2) presented with a very short delay while using the same rTMS routine as in session 2.
In session 2, the primary outcome measure will be the number of correctly remembered auditory stimuli. Secondary output will be reaction time during the recognition phase of the experiment.
In the control experiment (if conducted) the primary outcome measure will be the number of correct same/different judgments and, again, reaction time will be the secondary measure.
|Contact: Elaine P Considine, R.N.||(301) email@example.com|
|Contact: Mark Hallett, M.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Mark Hallett, M.D.||National Institute of Neurological Disorders and Stroke (NINDS)|