Study of Incidence of Respiratory Tract Adverse Events in Patients Treated With Tyvaso® Compared to Other FDA Approved Pulmonary Arterial Hypertension (PAH) Therapies (Aspire)

This study is currently recruiting participants.
Verified October 2012 by United Therapeutics
Sponsor:
Information provided by (Responsible Party):
United Therapeutics
ClinicalTrials.gov Identifier:
NCT01266265
First received: December 22, 2010
Last updated: October 5, 2012
Last verified: October 2012
  Purpose

A surveillance of respiratory tract related adverse events in patients treated with Tyvaso®(treprostinil) Inhalation Solution versus other FDA approved therapies


Condition Intervention
Pulmonary Arterial Hypertension
Drug: inhaled prostacyclin
Drug: prostacyclin
Drug: subcutaneous and intravenous prostacyclin
Drug: oral ERA
Drug: oral PDE5 inhibitors

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Postmarketing Observational Study to Assess Respiratory Tract Adverse Events in Pulmonary Arterial Hypertension Patients Treated With Tyvaso®(Treprostinil) Inhalation Solution

Resource links provided by NLM:


Further study details as provided by United Therapeutics:

Primary Outcome Measures:
  • Describe the type and incidence of oro-/nasopharyngeal and pulmonary adverse events that may be associated with current or recent treatment with Tyvaso for PAH [ Time Frame: Follow-up every 3 months ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Compare the incidence of selected oro-/nasopharyngeal and pulmonary adverse events in patients treated with Tyvaso for PAH with patients not treated with Tyvaso for PAH [ Time Frame: Follow-up every 3 months ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 1320
Study Start Date: December 2010
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Tyvaso Drug: inhaled prostacyclin
Tyvaso
Other Name: treprostinil
Control
Any other FDA approved therapies for PAH
Drug: inhaled prostacyclin
As prescribed by the physician
Other Name: iloprost, Ventavis
Drug: prostacyclin
As prescribed by the physician
Other Name: epoprostenol sodium, Flolan
Drug: subcutaneous and intravenous prostacyclin
As prescribed by physician
Other Name: treprostinil , Remodulin
Drug: oral ERA
As prescribed by physician
Other Names:
  • bosentan, Tracleer
  • ambrisentan, Letairis
Drug: oral PDE5 inhibitors
As prescribed by physician
Other Names:
  • sildenafil, Revatio
  • tadalafil, Adcirca

Detailed Description:

A post marketing surveillance to determine the type and incidence of oro/nasopharyngeal or pulmonary adverse events that may occur in patients treated with commercially available Tyvaso®(treprostinil) Inhalation Solution. A comparison will be made to the type and incidence of events in patients receiving other FDA approved therapies for pulmonary arterial hypertension, as a control measure.

  Eligibility

Ages Eligible for Study:   1 Year and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

community centers, academic institutions

Criteria

Inclusion Criteria:

  • Clinical diagnosis of PAH, WHO GROUP I
  • Prescribed and is currently receiving Tyvaso and/or other FDA-approved therapy for the treatment of PAH
  • Willing and able to provide written informed consent

Exclusion Criteria:

  • Previous initiation and permanent discontinuation of Tyvaso
  • Participation in an investigational clinical drug or device trial within 30 days of enrollment
  • Current or past diagnosis of lung neoplasm
  • Active gastrointestinal or pulmonary bleed at enrollment
  • Planned surgical intervention for treatment of PAH e.g., atrial septostomy or transplant
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01266265

  Hide Study Locations
Locations
United States, Alabama
Cardiovascular Associates, P.C. Recruiting
Birmingham, Alabama, United States, 35213
Contact: Donna Cole     205-599-6385     dcole@cvapc.com    
Principal Investigator: Barry Rayburn, MD            
The University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Rachel Culbreth     205-934-8767     chfnurse@cardiology.uab.edu    
Principal Investigator: Robert C. Bourge, MD            
University of South Alabama Recruiting
Mobile, Alabama, United States, 36693
Contact: Jennifer Smith     251-471-7291     jksmith@usouthal.edu    
Principal Investigator: Karen Fagan, MD            
United States, Arizona
Arizona Pulmonary Specialists, LTD Recruiting
Phoenix, Arizona, United States, 85013
Contact: Jeremy Feldman, MD     602-274-7195        
Principal Investigator: Jeremy Feldman, MD            
United States, California
Berkeley Cardiovascular Medical Group Recruiting
Berkeley, California, United States, 94705
Contact: Eileen Healy, NP     510-204-1691     healye@bcvmg.com    
Principal Investigator: Luisa Munoz, MD            
Cedars-Sinai Heart Institute Recruiting
Beverly Hills, California, United States, 90211
Contact: Tiffany Daun     310-248-7129     tiffany.daun@cshs.org    
Principal Investigator: Antoine Hage, MD            
University California San Francisco Recruiting
Fresno, California, United States, 93721
Contact: Sonja Garcia     559-459-4042     SGarcia@fresno.ucsf.edu    
Principal Investigator: Vijay Balasubramanian, MD            
University of Southern California Recruiting
Los Angeles, California, United States, 90033
Contact: Lynn Fukushima     323-442-9580     Lynn.Fukushima@med.usc.edu    
Principal Investigator: Sivagini Ganesh, MD            
West Los Angeles VA Healthcare Center Recruiting
Los Angeles, California, United States, 90073
Contact: Wendy Hill     310-268-4314     Wendy.Hill@va.gov    
Principal Investigator: Shelly Shapiro, MD            
University of California, San Francisco Recruiting
San Francisco, California, United States, 94143
Contact: Leslie Ziani     415-476-4014     lziani@medicine.ucsf.edu    
Principal Investigator: Dana McGlothlin, MD            
Paloma Medical Group Recruiting
San Juan Capistrano, California, United States, 92675
Contact: Theresa Schwarz, RN     949-443-4114     rn1232@hotmail.com    
Principal Investigator: Michael Rovzar, MD            
Santa Barbara Cottage Hospital Recruiting
Santa Barbara, California, United States, 93105
Contact: Zorina Schultz     805-569-7461     zschultz@sbch.org    
Principal Investigator: Jeffery Sager, MD            
Stanford Hospital and Clinics Recruiting
Stanford, California, United States, 94305
Contact: Val Scott         vscott@stanford.edu    
Principal Investigator: Roham Zamanian, MD            
United States, Colorado
Children's Hospital Denver Recruiting
Denver, Colorado, United States, 80045
Contact: Kathleen Miller-Reed, RN     720-777-6427     Miller-Reed.Kathleen@tchden.org    
Principal Investigator: D. Dunbar Ivy, MD            
Western States Clinical Research, Inc. Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Cheri Casey     303-940-9773     cheri@wscrinc.com    
Principal Investigator: Robert Benkert, MD            
United States, Florida
St. Francis Sleep Allergy & Lung Recruiting
Clearwater, Florida, United States, 33765
Contact: Ann Gove     727-447-3000 ext 222     agove@stfrancismed.com    
Principal Investigator: Frank Averill, MD            
University of Florida Recruiting
Gainesville, Florida, United States, 32610
Contact: Christina Eagan     352-273-8990     Christina.Eagan@medicine.ufl.edu    
Principal Investigator: Hassan Alnuaimat, MD            
University of Florida College of Medicine Jacksonville Recruiting
Jacksonville, Florida, United States, 32209
Contact: Minal Patel     904-244-1106     Minal.Patel@jax.ufl.edu    
Principal Investigator: Abubakr Bawja, MD            
Mayo Clinic Jacksonville Recruiting
Jacksonville, Florida, United States, 32224
Contact: Shannon Kennedy     904-953-7439     kennedy.shannon@mayo.edu    
Principal Investigator: Charles Burger, MD            
Pulmonary and Critical Care Associates Recruiting
Jacksonville, Florida, United States, 32204
Contact: Ronni Wetmore     904-366-3738     rwetmore@paccaweb.com    
Principal Investigator: Mitchell Rothstein, MD            
Miami Center for Cardiovascular Disease Recruiting
Miami, Florida, United States, 33136
Contact: Adriana Silva     786-250-9399     adriana0513.as@gmail.com    
Principal Investigator: Javier Jimenez, MD            
Mount Sinai Medical Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Helen Garcia     305-674-2162     helen.garcia@msmc.com    
Principal Investigator: Esteban Escolar, MD            
Central Florida Pulmonary Group, P.A. Recruiting
Orlando, Florida, United States, 32806
Contact: Linda Tilme         ltilme@gcrm.com    
Principal Investigator: Daniel Layish, MD            
Orlando Heart Center Recruiting
Orlando, Florida, United States, 32806
Contact: Sally Hewit     407-650-1348     SHewit@orlandoheart.com    
Principal Investigator: James Tarver, III, MD            
Cleveland Clinic Florida Recruiting
Weston, Florida, United States, 33331
Contact: Norma Jean Barton         bartonn2@ccf.org    
Principal Investigator: Franck F Rahaghi, MD            
United States, Georgia
Emory University School of Medicine Recruiting
Atlanta, Georgia, United States, 30322
Contact: Jane Gillespie     404-712-8204     jegille@emory.edu    
Principal Investigator: Micah Fisher, MD            
Georgia Lung Associates, PC Recruiting
Austell, Georgia, United States, 30106
Contact: Stacy Beasley     770-745-1404 ext 4     sbeasley_gcr@yahoo.com    
Principal Investigator: Chad Miller, MD            
United States, Illinois
Northwestern Medical Center Recruiting
Chicago, Illinois, United States, 60611
Contact: Jinal Gangar, MBBS,MPH     312-695-2269     drjinalgangar@northwestern.edu    
Principal Investigator: Michael Cuttica, MD            
University of Illinois at Chicago Recruiting
Chicago, Illinois, United States, 60612
Contact: Nancy Casanova     312-355-5934     ngcasan@uic.edu    
Principal Investigator: Roberto Machado, MD            
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Joyce Brown     312-942-6771     Joyce_Brown@rush.edu    
Principal Investigator: Rajive Tandon, MD            
Midwest Heart Foundation Recruiting
Oakbrook Terrace, Illinois, United States, 60181
Contact: Debbie Heidenreich     630-873-3406     dheidenreich@midwestheart.org    
Principal Investigator: Maria Rosa Costanzo, MD            
United States, Indiana
Indiana University Hospital Recruiting
Carmel, Indiana, United States, 46032
Contact: Betty Logan, MD     317-688-3846     blogan@iuhealth.org    
Principal Investigator: William Harvey, MD            
United States, Iowa
University of Iowa Recruiting
Iowa City, Iowa, United States, 52242
Contact: Tiffany Kriegel     319-384-6558     tiffany-kriegel@uiowa.edu    
Principal Investigator: Sif Hansdottir, MD            
Mercy Hospital Recruiting
Iowa City, Iowa, United States, 52245
Contact: Amy Becker, RN     319-688-7026     Amy.Becker@mercyic.org    
Principal Investigator: Andrew Ashby, MD            
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Stephanie Thomas-Dodson     913-588-4022     sthomas-dodson@kumc.edu    
Principal Investigator: Tim Williamson, MD            
United States, Kentucky
Kentuckiana Pulmonary Associates Recruiting
Louisville, Kentucky, United States, 40202
Contact: Kim Hobbs     502-587-8000     khobbs@kpadocs.com    
Principal Investigator: Wes John McConnell, MD            
United States, Maryland
Johns Hopkins University Recruiting
Baltimore, Maryland, United States, 21205
Contact: Jude Aidam         jaidam1@jhu.edu    
Principal Investigator: Stephen Mathai, MD            
University of Maryland Recruiting
Baltimore, Maryland, United States, 21201
Contact: Faith Janowick     410-328-4433     fjanowic@medicine.umaryland.edu    
Principal Investigator: Myung Park, MD            
United States, Massachusetts
Tufts - New England Medical Center Recruiting
Boston, Massachusetts, United States, 02111
Contact: Karen Visnaw, RN     617-636-1334     kvisnaw@tuftsmedicalcenter.org    
Principal Investigator: Nicholas Hill, MD            
Brigham and Women's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Laurie Lawler, RN     617-525-9731     LLAWLER@PARTNERS.ORG    
Principal Investigator: Aaron Waxman, MD            
United States, Michigan
Henry Ford Health System Recruiting
Detroit, Michigan, United States, 48202
Contact: Marcie Major     313-916-2433     MMAJOR1@hfhs.org    
Principal Investigator: Hector Cajigas, MD            
William Beaumont Hospital Recruiting
Troy, Michigan, United States, 48085
Contact: Coleen Tessmar     248-964-8524     ctessmar@beaumont.edu    
Principal Investigator: Samuel Allen, MD            
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Louise Durst         louise.durst@mayo.edu    
Principal Investigator: Robert Frantz, MD            
United States, Nebraska
Nebraska Pulmonary Specialties, LLC Recruiting
Lincoln, Nebraska, United States, 68506
Contact: Lisa Whisenhut     402-483-8684     lisaw@npsllc.org    
Principal Investigator: Jeffrey Jarrett, MD            
United States, New Jersey
Hackensack University Medical Center Recruiting
Hackensack, New Jersey, United States, 07601
Contact: Diane Agar         DAgar@HackensackUMC.org    
Principal Investigator: Robert Berkowitz, MD            
UMDNJ - Robert Wood Johnson Medical Center Clinical Research Center Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Deborah McCloskey         mcclosda@umdnj.edu    
Principal Investigator: Vivien Hsu, MD            
Newark Beth Israel Medical Center Recruiting
Newark, New Jersey, United States, 07112
Contact: Juliet Williams     973-926-8578     JuWilliams@SBHCS.com    
Principal Investigator: Sean Studer, MD            
United States, New York
SUNY Stony Brook University Medical Center Recruiting
Islandia, New York, United States, 11790
Contact: Jacqueline Skarre         jacqueline.skarre@stonybrook.edu    
Principal Investigator: Paul Strachan, MD            
Winthrop Pulmonary Associates Recruiting
Mineola, New York, United States, 11501
Contact: Kim Byrnes, LPN         kbyrnes@winthrop.org    
Principal Investigator: Shilpa Ann DeSouza, MD            
North Shore - Long Island Jewish Health System Recruiting
New Hyde Park, New York, United States, 11040
Contact: Rebecca Miller     516-465-5447     rmiller6@nshs.edu    
Principal Investigator: Arunabh Talwar, MD            
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Katherine Whee     212-305-4436     kl2454@columbia.edu    
Principal Investigator: Erika Berman-Rosenzweig, MD            
St. Luke's-Roosevelt Hospital Center Recruiting
New York, New York, United States, 10019
Contact: Lori Tartell     212-523-5471     LTARTELL@CHPNET.ORG    
Principal Investigator: Ruth Minkin, MD            
Mary M Parkes Center Recruiting
Rochester, New York, United States, 14623
Contact: Toni Heininger     585-486-0147 ext 123     antonia_heininger@urmc.rochester.edu    
Principal Investigator: R. James White, MD            
Pulmonary Health Physicians Recruiting
Syracuse, New York, United States, 13210
Contact: Cathy Fogus     315-234-0816     cathy.fogus@cnylungs.com    
Principal Investigator: Sherif El Bayadi, MD            
United States, North Carolina
University of North Carolina at Chapel Hill Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Sarah McGee     919-966-2531     smcgee@med.unc.edu    
Principal Investigator: Hubert Ford, MD            
Pinehurst Medical Clinic Recruiting
Pinehurst, North Carolina, United States, 28374
Contact: Brenda Sanders     910-235-3142     basanders@pinehurstmedical.com    
Principal Investigator: Michael Pritchett, MD            
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Gayle Marterre     336-716-0573     gmarterr@wakehealth.edu    
Principal Investigator: Rodolfo Pascual, MD            
United States, Ohio
Akron General Hospital Recruiting
Akron, Ohio, United States, 44302
Contact: Debbie Hudock     330-344-1570     dhudock@agmc.org    
Principal Investigator: Michael Passero, MD            
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267-0564
Contact: Tammy Roads     513-558-2148     roadst@ucmail.uc.edu    
Principal Investigator: Jean Elwing, MD            
University Hospitals of Cleveland Recruiting
Cleveland, Ohio, United States, 44106
Contact: David Haney     216-844-2381     david.haney@uhhospitals.org    
Principal Investigator: Robert Schliz, MD            
Davis Heart and Lung Research Institute Recruiting
Columbus, Ohio, United States, 43210
Contact: Laura Yamokoski     614-247-7793     Laura.Yamokoski@osumc.edu    
Principal Investigator: Veronica Franco, MD            
Mercy Fairfield Hospital Recruiting
Fairfield, Ohio, United States, 45014
Contact: MaryLou Sauer     513-603-8236     smdsauer@yahoo.com    
Principal Investigator: Lynne Wagoner, MD            
United States, Oregon
OHSU-Oregon Health and Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Kristen Baptiste         baptiste@ohsu.edu    
Principal Investigator: Akram Khan, MD            
Legacy Pulmonary Northwest Recruiting
Portland, Oregon, United States, 97210
Contact: Tamara Mayfield     503-413-7945     TMayfiel@LHS.ORG    
Principal Investigator: Catherine Markin, MD            
Oregon Clinic, PC Recruiting
Portland, Oregon, United States, 97220
Contact: Meg Day     503-963-3182     mday@orclinic.com    
Principal Investigator: Rhett Cummings, MD            
United States, Pennsylvania
Penn State Milton S. Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033
Contact: Robert Vender, MD         rvender@hmc.psu.edu    
Principal Investigator: Robert Vender, MD            
Thomas Jefferson University Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Paul Park     215-503-4070     paul.park@jefferson.edu    
Principal Investigator: Michael Scharf, MD            
Children's Hospital of Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Jeannie Acampora         acampora@email.chop.edu    
Principal Investigator: Brian Hanna, MD            
Temple University Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Melody Santiago         Melody.Santiago@tuhs.temple.edu    
Principal Investigator: Shelia Weaver, MD            
University of Pennsylvania Health System Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Christine Malloy     215-513-2999     christine.malloy@uphs.upenn.edu    
Principal Investigator: Eduardo Rame, MD            
Allegheny General Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15212
Contact: Pranav Ravi     412-359-6691     pravi@wpahs.org    
Principal Investigator: Raymond Benza, MD            
University of Pittsburgh Medical Center Recruiting
Pittsburgh, Pennsylvania, United States, 15213-2582
Contact: Paula M. McGrath     412-692-2769     McGrathPM@upmc.edu    
Principal Investigator: Michael Mathier, MD            
Berks Schuylkill Respiratory Specialists, Ltd. Recruiting
Wyomissing, Pennsylvania, United States, 19610
Contact: Lisa Hill     610-685-5864 ext 166     lhill@lungmd.net    
Principal Investigator: Alec Platt, MD            
United States, Rhode Island
Rhode Island Hospital Recruiting
Providence, Rhode Island, United States, 02903
Contact: Barbara Smithson     401-444-9097     BSmithson@Lifespan.org    
Principal Investigator: James Klinger, MD            
United States, South Carolina
Lexington Pulmonary and Critical Care Recruiting
Lexington, South Carolina, United States, 29072
Contact: Christina Derienzo, RN     803-394-7279     cderienzo@lexpcc.net    
Principal Investigator: Donald Elton, MD            
United States, Tennessee
MD Total Care, PLLC Recruiting
Chattanooga, Tennessee, United States, 37419
Contact: Eva Malaspino     423-710-3864     clinicaltrails_MDTC@earthlink.net    
Principal Investigator: Michael Czarnecki, MD            
Summit Medical Group Recruiting
Knoxville, Tennessee, United States, 37909
Contact: Monica Goins     423-989-3105     mgoins@pmg-research.com    
Principal Investigator: John Swisher, MD            
Vanderbilt University Medical Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Shelly Gonzalez     615-343-8277     rochelle.gonzalez@Vanderbilt.Edu    
Principal Investigator: Ivan Robbins, MD            
United States, Texas
UT Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Yvonne Pena     214-645-7148     Yvonne.Pena@UTSouthwestern.edu    
Principal Investigator: Sonja Bartolome, MD            
Texas Children's Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Charles Sellers     832-822-4790     cxseller@texaschildrens.org    
Principal Investigator: Fadel Ruiz, MD            
University of Texas Health Science Center at Houston Recruiting
Houston, Texas, United States, 77030
Contact: Kristi Baysinger     713-500-6851     Kristi.L.Baysinger@uth.tmc.edu    
Principal Investigator: Bela Patel, MD            
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Jennifer L Lee     713-798-2400     jllee@bcm.edu    
Principal Investigator: Zeenat Safdar, MD            
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Regina Whitener, RN     210-617-5300 ext 14549     WHITENER@uthscsa.edu    
Principal Investigator: Deborah Levine, MD            
Methodist Healthcare System of San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Gloria Carreon     210-575-3064     Gloria.Carreon@MHShealth.com    
Principal Investigator: Michael Kwan, MD            
United States, Virginia
Inova Fairfax Hospital Recruiting
Falls Church, Virginia, United States, 22042
Contact: Mary Smith     703-776-7128     marya.smith@inova.org    
Principal Investigator: Oksana Shlobin, MD            
Sentara Cardiovascular Research Institute Recruiting
Norfolk, Virginia, United States, 23507
Contact: Melinda Bullivant, RN, MSN     757-388-4024     MMBULLIV@sentara.com    
Principal Investigator: Michael Eggert, MD            
United States, Wisconsin
Aurora Health Care Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Valerie Zindars, RN     414-649-6853     valerie.zindars@aurora.org    
Principal Investigator: Dianne Zwicke, MD            
Sponsors and Collaborators
United Therapeutics
  More Information

No publications provided

Responsible Party: United Therapeutics
ClinicalTrials.gov Identifier: NCT01266265     History of Changes
Other Study ID Numbers: RIN-PH-403
Study First Received: December 22, 2010
Last Updated: October 5, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by United Therapeutics:
pulmonary arterial hypertension
PAH
treprostinil sodium
Tyvaso
inhalation
Ventavis
iloprost
prostacyclin
epoprostenol sodium
Flolan
subcutaneous and intravenous prostacyclin analogue
Remodulin
oral ERA
bosentan
Tracleer
ambrisentan
Letairis
oral PDE5 inhibitors
sildenafil
Revatio
tadalafil
Adcirca

Additional relevant MeSH terms:
Hypertension, Pulmonary
Hypertension
Lung Diseases
Respiratory Tract Diseases
Vascular Diseases
Cardiovascular Diseases
Epoprostenol
Iloprost
Treprostinil
Bosentan
Tezosentan
Sildenafil
Tadalafil
Phosphodiesterase 5 Inhibitors
Platelet Aggregation Inhibitors
Hematologic Agents
Therapeutic Uses
Pharmacologic Actions
Antihypertensive Agents
Cardiovascular Agents
Vasodilator Agents
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on June 17, 2013