Impaired Decision-making in Adolescents
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Purpose
There is clear evidence that aggressive behavior and disruptive behavior disorders (DBD) in middle childhood are associated with an increased risk for substance abuse in adolescence. However, the exact underlying mechanism of this increased risk is unknown. It is likely that a biopsychological vulnerability in some aggressive children and children with DBD makes them liable to substance use and abuse. The investigators hypothesize that deficient decision making is such a biopsychological factor. In this study the investigators aim to test the latter hypothesis by investigating the decision making ability in a group of adolescents with DBD with and without substance use disorders. Decision-making is assessed with the IOWA Gambling Task (GT). This task mimics real-life situations in the way it factors uncertainty, reward and punishment. The GT is specifically designed to assess impaired decision-making in individuals who are unable to learn from their mistakes and make decisions that repeatedly lead to negative consequences. This characteristic may be common to individuals with externalizing disorders such as DBD, psychopathy, and substance use disorders.
| Condition | Phase |
|---|---|
|
Adolescent Psychiatry Antisocial Personality Disorders Substance-Related Disorders |
Phase 0 |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Impaired Decision-making in Adolescents: A Vulnerability Factor for the Development of Substance Use and Abuse. |
| Enrollment: | 152 |
| Study Start Date: | April 2006 |
| Study Completion Date: | September 2007 |
| Primary Completion Date: | June 2007 (Final data collection date for primary outcome measure) |
This study consists of two substudies with adolescents in the age of 14-21 years. The first study group consist of adolescents with DBD with (n=30) and without (n=30) substance use disorders. These adolescents are recruited from orthopsychiatric, forensic psychiatric, and judicial institutions.
The second study group consists of a) ex-patients of the Utrecht Coping Power Program (UCPP)who previously participated to a follow-up study, and b) ex-patients who were treated as a child at an outpatient clinic of the UMC Utrecht. These latter groups were taken together and subdivided into a group with (n=30) and without (n=30) substance use problems.
For both studies healthy controls (n=80) are recruited. The investigators will start with healthy controls from earlier studies, and those are extented and will serve as control group for both studies.
Eligibility| Ages Eligible for Study: | 14 Years to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
DBD adolescents were recruited from judicial and forensic institutions. Healthy controls consisted of volunteers.
Inclusion Criteria:
- Having a DISC diagnosis DBD
Exclusion Criteria:
- Having the DISC diagnosis Schizophrenia
Contacts and Locations| Netherlands | |
| University Medical Center Utrecht | |
| Utrecht, Netherlands, 3584 CX | |
| Principal Investigator: | Walter Matthys, MD, PhD | UMC Utrecht |
More Information
Publications:
| Responsible Party: | W. Matthys, UMC Utrecht |
| ClinicalTrials.gov Identifier: | NCT01253993 History of Changes |
| Other Study ID Numbers: | 05-271, ZonMw 31100001, NIDA DA 16135 |
| Study First Received: | March 2, 2007 |
| Last Updated: | December 3, 2010 |
| Health Authority: | Netherlands: Medical Ethics Review Committee (METC) |
Keywords provided by UMC Utrecht:
|
Disruptive Behavior Disorders, Substance abuse, Iowa Gambling Task, Decision Making. |
Additional relevant MeSH terms:
|
Antisocial Personality Disorder Personality Disorders Substance-Related Disorders Mental Disorders |
ClinicalTrials.gov processed this record on June 18, 2013