Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
AstraZeneca
ClinicalTrials.gov Identifier:
NCT01225562
First received: July 9, 2010
Last updated: June 3, 2014
Last verified: June 2014
  Purpose

This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).


Condition Intervention Phase
Myocardial Infarction
Cardiovascular Death
Atherothrombosis
Stroke
Drug: Ticagrelor 90 mg
Drug: Ticagrelor 60 mg
Drug: Ticagrelor Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction

Resource links provided by NLM:


Further study details as provided by AstraZeneca:

Primary Outcome Measures:
  • Any event after randomization from the composite of cardiovascular death, non-fatal MI, or non-fatal stroke. [ Time Frame: Within 1 year to 44 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Cardiovascular death after randomization [ Time Frame: Within 1 year to 44 months ] [ Designated as safety issue: No ]
  • All-cause mortality after randomization [ Time Frame: Within 1 year to 44 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 21000
Study Start Date: October 2010
Estimated Study Completion Date: November 2014
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Oral Treatment
Drug: Ticagrelor 90 mg
Oral dose twice a day
Experimental: 2
Oral Treatment
Drug: Ticagrelor 60 mg
Oral dose twice a day
Placebo Comparator: 3
Oral Treatment
Drug: Ticagrelor Placebo
Oral dose twice a day

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
  • Females of child-bearing potential must have a negative pregnancy test at enrollment
  • Persons who are currently taking aspirin between 75 and 150 mg once daily

Exclusion Criteria:

  • Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
  • Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
  • Persons with known bleeding disorders
  • Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
  • Persons with a history of ischemic stroke
  • Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
  • Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
  • Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
  • Persons with known severe liver disease
  • Persons with kidney failure requiring dialysis
  • Persons with life expectancy < 1 year
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01225562

  Hide Study Locations
Locations
United States, Alabama
Research Site
Alexander City, Alabama, United States
Research Site
Athens, Alabama, United States
Research Site
Birmingham, Alabama, United States
Research Site
Huntsville, Alabama, United States
Research Site
Mobile, Alabama, United States
Research Site
Sheffield, Alabama, United States
United States, Arizona
Research Site
Phoenix, Arizona, United States
United States, Arkansas
Research Site
Jonesboro, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
United States, California
Research Site
Alhambra, California, United States
Research Site
Anaheim, California, United States
Research Site
Bakersfield, California, United States
Research Site
Fountain Valley, California, United States
Research Site
La Mesa, California, United States
Research Site
Larkspur, California, United States
Research Site
Lomita, California, United States
Research Site
Los Angeles, California, United States
Research Site
Modesto, California, United States
Research Site
Newport Beach, California, United States
Research Site
Oakland, California, United States
Research Site
Oceanside, California, United States
Research Site
San Diego, California, United States
Research Site
San Marino, California, United States
Research Site
Santa Rosa, California, United States
Research Site
Ventura, California, United States
Research Site
Westlake Village, California, United States
United States, Colorado
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Littleton, Colorado, United States
Research Site
Loveland, Colorado, United States
United States, Connecticut
Research Site
Hartford, Connecticut, United States
Research Site
Stamford, Connecticut, United States
United States, Delaware
Research Site
Newark, Delaware, United States
United States, District of Columbia
Research Site
Washington, District of Columbia, United States
United States, Florida
Research Site
Boca Raton, Florida, United States
Research Site
Clearwater, Florida, United States
Research Site
Coral Springs, Florida, United States
Research Site
Crystal River, Florida, United States
Research Site
Davie, Florida, United States
Research Site
Daytona, Florida, United States
Research Site
Daytona Beach, Florida, United States
Research Site
Ft Lauderdale, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Hialeah, Florida, United States
Research Site
Hollywood, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
Jupiter, Florida, United States
Research Site
Largo, Florida, United States
Research Site
Leesburg, Florida, United States
Research Site
Miami, Florida, United States
Research Site
Miami Beach, Florida, United States
Research Site
Naples, Florida, United States
Research Site
Ocala, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Pannama City, Florida, United States
Research Site
Pensacola, Florida, United States
Research Site
Port Charlotte, Florida, United States
Research Site
Safety Harbor, Florida, United States
Research Site
Sarasota, Florida, United States
Research Site
South Miami, Florida, United States
Research Site
St Petersburg, Florida, United States
Research Site
Tallahassee, Florida, United States
Research Site
The Villages, Florida, United States
Research Site
Wellington, Florida, United States
Research Site
West Palm Beach, Florida, United States
United States, Georgia
Research Site
Atlanta, Georgia, United States
Research Site
Augusta, Georgia, United States
Research Site
Cumming, Georgia, United States
Research Site
Peachtree Dunwoody Road, Georgia, United States
United States, Hawaii
Research Site
Honolulu, Hawaii, United States
United States, Idaho
Research Site
Boise, Idaho, United States
United States, Illinois
Research Site
Aurora, Illinois, United States
Research Site
Bannockburn, Illinois, United States
Research Site
Chicago, Illinois, United States
Research Site
Melrose Park, Illinois, United States
Research Site
Normal, Illinois, United States
Research Site
Rock Island, Illinois, United States
United States, Indiana
Research Site
Avon, Indiana, United States
Research Site
Elkhart, Indiana, United States
Research Site
Fort Wayne, Indiana, United States
Research Site
Franklin, Indiana, United States
Research Site
Hammond, Indiana, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Muncie, Indiana, United States
United States, Iowa
Research Site
Iowa City, Iowa, United States
United States, Kansas
Research Site
Hutchinson, Kansas, United States
United States, Kentucky
Research Site
Crestview Hills, Kentucky, United States
Research Site
Lexington, Kentucky, United States
Research Site
Louisville, Kentucky, United States
United States, Louisiana
Research Site
Alexandria, Louisiana, United States
Research Site
Covington, Louisiana, United States
Research Site
Minden, Louisiana, United States
Research Site
New Iberia, Louisiana, United States
Research Site
Opelousas, Louisiana, United States
Research Site
Shreveport, Louisiana, United States
Research Site
Slidell, Louisiana, United States
United States, Maine
Research Site
Auburn, Maine, United States
Research Site
Bangor, Maine, United States
Research Site
Biddeford, Maine, United States
Research Site
S Portland, Maine, United States
United States, Maryland
Research Site
Baltimore, Maryland, United States
Research Site
Columbia, Maryland, United States
Research Site
Oxon Hill, Maryland, United States
Research Site
Salisbury, Maryland, United States
United States, Massachusetts
Research Site
Ayer, Massachusetts, United States
Research Site
Boston, Massachusetts, United States
Research Site
Burlington, Massachusetts, United States
Research Site
Haverhill, Massachusetts, United States
Research Site
North Dartmouth, Massachusetts, United States
United States, Michigan
Research Site
Alpena, Michigan, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Detroit, Michigan, United States
Research Site
Flint, Michigan, United States
Research Site
Grand Blanc, Michigan, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Jackson, Michigan, United States
Research Site
Lapeer, Michigan, United States
Research Site
Marquette, Michigan, United States
Research Site
Petoskey, Michigan, United States
Research Site
Pontiac, Michigan, United States
Research Site
Saginaw, Michigan, United States
Research Site
Southfield, Michigan, United States
Research Site
Ypsilanti, Michigan, United States
United States, Minnesota
Research Site
Baxter, Minnesota, United States
Research Site
Duluth, Minnesota, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Robbinsdale, Minnesota, United States
Research Site
St Cloud, Minnesota, United States
United States, Mississippi
Research Site
Biloxi, Mississippi, United States
Research Site
Tupelo, Mississippi, United States
United States, Missouri
Research Site
Columbia, Missouri, United States
Research Site
Kansas City, Missouri, United States
Research Site
St Louis, Missouri, United States
United States, Montana
Research Site
Billings, Montana, United States
Research Site
Great Falls, Montana, United States
Research Site
Kalispell, Montana, United States
United States, Nebraska
Research Site
Lincoln, Nebraska, United States
Research Site
Omaha, Nebraska, United States
Research Site
Papillion, Nebraska, United States
United States, Nevada
Research Site
Reno, Nevada, United States
United States, New Jersey
Research Site
Bridgewater, New Jersey, United States
Research Site
Elizabeth, New Jersey, United States
Research Site
Elmer, New Jersey, United States
Research Site
Haddon Heights, New Jersey, United States
Research Site
Linden, New Jersey, United States
Research Site
Newark, New Jersey, United States
Research Site
Ridgewood, New Jersey, United States
Research Site
Somerset, New Jersey, United States
United States, New Mexico
Research Site
Albuquerque, New Mexico, United States
United States, New York
Research Site
Bronx, New York, United States
Research Site
Buffalo, New York, United States
Research Site
Cortlandt Manor, New York, United States
Research Site
Mineola, New York, United States
Research Site
New Windsor, New York, United States
Research Site
Poughkeepsie, New York, United States
Research Site
Saratoga Springs, New York, United States
Research Site
Southampton, New York, United States
Research Site
Stony Brook, New York, United States
Research Site
Williamsville, New York, United States
United States, North Carolina
Research Site
Asheville, North Carolina, United States
Research Site
Burlington, North Carolina, United States
Research Site
Cary, North Carolina, United States
Research Site
Greensboro, North Carolina, United States
Research Site
Hickory, North Carolina, United States
Research Site
Morganton, North Carolina, United States
Research Site
Pinehurst, North Carolina, United States
Research Site
Raleigh, North Carolina, United States
Research Site
Rocky Mount, North Carolina, United States
Research Site
Sanford, North Carolina, United States
Research Site
Smithfield, North Carolina, United States
Research Site
Statesville, North Carolina, United States
Research Site
Wilmington, North Carolina, United States
United States, North Dakota
Research Site
Grand Forks, North Dakota, United States
United States, Ohio
Research Site
Akron, Ohio, United States
Research Site
Canton, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Cleveland, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Dayton, Ohio, United States
Research Site
Fairfield, Ohio, United States
Research Site
Mansfield, Ohio, United States
Research Site
Sandusky, Ohio, United States
Research Site
Springfield, Ohio, United States
Research Site
Toledo, Ohio, United States
Research Site
Youngstown, Ohio, United States
Research Site
Zanesville, Ohio, United States
United States, Oklahoma
Research Site
Oklahoma City, Oklahoma, United States
Research Site
Tulsa, Oklahoma, United States
United States, Oregon
Research Site
Bend, Oregon, United States
Research Site
Portland, Oregon, United States
United States, Pennsylvania
Research Site
Altoona, Pennsylvania, United States
Research Site
Beaver, Pennsylvania, United States
Research Site
Bethlehem, Pennsylvania, United States
Research Site
Chambersburg, Pennsylvania, United States
Research Site
Doylestown, Pennsylvania, United States
Research Site
Erie, Pennsylvania, United States
Research Site
Johnstown, Pennsylvania, United States
Research Site
Lancaster, Pennsylvania, United States
Research Site
Langhorne, Pennsylvania, United States
Research Site
Mine Hill, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Scranton, Pennsylvania, United States
Research Site
Sellersville, Pennsylvania, United States
Research Site
West Chester, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
United States, Rhode Island
Research Site
Providence, Rhode Island, United States
United States, South Carolina
Research Site
Anderson, South Carolina, United States
Research Site
Charleston, South Carolina, United States
Research Site
Florence, South Carolina, United States
Research Site
Greenville, South Carolina, United States
United States, South Dakota
Research Site
Rapid City, South Dakota, United States
Research Site
Watertown, South Dakota, United States
United States, Tennessee
Research Site
Germantown, Tennessee, United States
Research Site
Jackson, Tennessee, United States
Research Site
Knoxville, Tennessee, United States
Research Site
Nashville, Tennessee, United States
Research Site
Oak Ridge, Tennessee, United States
Research Site
Tullahoma, Tennessee, United States
United States, Texas
Research Site
Austin, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
Fort Worth, Texas, United States
Research Site
Georgetown, Texas, United States
Research Site
Grapevine, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Katy, Texas, United States
Research Site
Kingwood, Texas, United States
Research Site
MC Allen, Texas, United States
Research Site
Mission, Texas, United States
Research Site
Plano, Texas, United States
Research Site
Round Rock, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Tomball, Texas, United States
Research Site
Tyler, Texas, United States
Research Site
Victoria, Texas, United States
United States, Utah
Research Site
Provo, Utah, United States
United States, Vermont
Research Site
Burlington, Vermont, United States
United States, Virginia
Research Site
Alexandria, Virginia, United States
Research Site
Charlottesville, Virginia, United States
Research Site
Danville, Virginia, United States
Research Site
Falls Church, Virginia, United States
Research Site
Lynchburg, Virginia, United States
Research Site
Manassas, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Winchester, Virginia, United States
United States, Washington
Research Site
Bellevue, Washington, United States
Research Site
Everett, Washington, United States
Research Site
Spokane, Washington, United States
Research Site
Tacoma, Washington, United States
United States, Wisconsin
Research Site
Green Bay, Wisconsin, United States
Research Site
Wausau, Wisconsin, United States
Argentina
Research Site
Bahia Blanca, Buenos Aires, Argentina
Research Site
Ciudad Autonoma de BA, Buenos Aires, Argentina
Research Site
Ciudadela, Buenos Aires, Argentina
Research Site
Coronel Suarez, Buenos Aires, Argentina
Research Site
Haedo, Buenos Aires, Argentina
Research Site
La Plata, Buenos Aires, Argentina
Research Site
Mar del Plata Buenos Aires, Buenos Aires, Argentina
Research Site
Ramos Mejía, Buenos Aires, Argentina
Research Site
San Nicolas, Buenos Aires, Argentina
Research Site
Zarate, Buenos Aires, Argentina
Research Site
Córdoba, Córdoba-Argentina, Argentina
Research Site
Cordoba, Córdoba, Argentina
Research Site
San Salvador de Jujuy, Jujuy, Argentina
Research Site
Corrientes, Pcia Corrientes, Argentina
Research Site
Rosario, Santa Fe - Argentina, Argentina
Research Site
Rosario, Santa Fe, Argentina
Research Site
Rosario Santa Fe, Santa Fe, Argentina
Research Site
Santa Fé, Santa Fé - Argentina, Argentina
Research Site
Rosario, Sante Fe, Argentina
Research Site
Tucuman, Tucuman - Argentina, Argentina
Research Site
Tucuman, Tucuman-Argentina, Argentina
Research Site
Buenos Aires, Argentina
Research Site
Ciudad de Buenos Aires, Argentina
Research Site
Cordoba, Argentina
Research Site
Mar del Plata, Argentina
Research Site
San Luis, Argentina
Research Site
Santa Fe, Argentina
Research Site
Tucumán, Argentina
Australia, Australian Capital Territory
Research Site
Bruce, Australian Capital Territory, Australia
Australia, New South Wales
Research Site
Concord, New South Wales, Australia
Research Site
Gosford, New South Wales, Australia
Research Site
Kingswood, New South Wales, Australia
Research Site
Kogorah, New South Wales, Australia
Research Site
New Lambton Heights, New South Wales, Australia
Research Site
St Leonards, New South Wales, Australia
Research Site
Wollongong, New South Wales, Australia
Australia, Queensland
Research Site
Auchenflower, Queensland, Australia
Research Site
Chermside, Queensland, Australia
Research Site
Greenslopes, Queensland, Australia
Research Site
Herston, Queensland, Australia
Research Site
Woolloongabba, Queensland, Australia
Australia, South Australia
Research Site
Adelaide, South Australia, Australia
Research Site
Ashford, South Australia, Australia
Research Site
Elizabeth Vale, South Australia, Australia
Research Site
Woodville, South Australia, Australia
Australia, Tasmania
Research Site
Launceston, Tasmania, Australia
Australia, Victoria
Research Site
Ballarat, Victoria, Australia
Research Site
Clayton, Victoria, Australia
Research Site
East St Kilda, Victoria, Australia
Research Site
Geelong, Victoria, Australia
Research Site
Melbourne, Victoria, Australia
Research Site
Richmond, Victoria, Australia
Australia, Western Australia
Research Site
Fremantle, Western Australia, Australia
Research Site
Joondalup, Western Australia, Australia
Research Site
Nedlands, Western Australia, Australia
Australia
Research Site
Epping, Australia
Belgium
Research Site
Aalst, Belgium
Research Site
Antwerpen, Belgium
Research Site
Bonheiden, Belgium
Research Site
Bouge, Belgium
Research Site
Brasschaat, Belgium
Research Site
Brussels, Belgium
Research Site
Brussels (Anderlecht), Belgium
Research Site
Brussels (Jette), Belgium
Research Site
Brussels (Woluwé-St-Lambert), Belgium
Research Site
Charleroi, Belgium
Research Site
Edegem, Belgium
Research Site
Genk, Belgium
Research Site
Gent, Belgium
Research Site
Hasselt, Belgium
Research Site
Huy, Belgium
Research Site
La Louvière, Belgium
Research Site
Leuven, Belgium
Research Site
Liege, Belgium
Research Site
Liège, Belgium
Research Site
Mechelen, Belgium
Research Site
Mol, Belgium
Research Site
Ottignies, Belgium
Research Site
Roeselare, Belgium
Research Site
Tienen, Belgium
Research Site
Turnhout, Belgium
Research Site
Yvoir, Belgium
Research Site
Zottegem, Belgium
Brazil
Research Site
Maceio, Alagoas, Brazil
Research Site
Salvador, BA, Brazil
Research Site
Brasília, DF, Brazil
Research Site
Goiânia, GO, Brazil
Research Site
Belo Horizonte, Minas Gerais, Brazil
Research Site
Uberlândia, Minas Gerais, Brazil
Research Site
Campo Grande, MS, Brazil
Research Site
Campina Grande do Sul, PR, Brazil
Research Site
Curitiba, PR, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, Brazil
Research Site
Rio de Janeiro, Ro de Janeiro, Brazil
Research Site
Porto Alegre, RS, Brazil
Research Site
Blumenau, Santa Catarina, Brazil
Research Site
Votuporanga, Sao Paulo, Brazil
Research Site
Aracaju, SE, Brazil
Research Site
Campinas, SP, Brazil
Research Site
Marilia, SP, Brazil
Research Site
Ribeirão Preto, SP, Brazil
Research Site
S.J.Rio Preto, SP, Brazil
Research Site
São José do Rio Preto, SP, Brazil
Research Site
São Paulo, SP, Brazil
Research Site
Campinas, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
São Paulo, Brazil
Bulgaria
Research Site
Dimitrovgrad, Bulgaria
Research Site
Gotse Delchev, Bulgaria
Research Site
Pernik, Bulgaria
Research Site
Pleven, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Razlog, Bulgaria
Research Site
Ruse, Bulgaria
Research Site
Sevlievo, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Veliko Tarnovo, Bulgaria
Canada, Alberta
Research Site
Edmonton, Alberta, Canada
Canada, British Columbia
Research Site
Kelowna, British Columbia, Canada
Research Site
New Westminster, British Columbia, Canada
Research Site
Penticton, British Columbia, Canada
Research Site
Surrey, British Columbia, Canada
Research Site
Vancouver, British Columbia, Canada
Research Site
Victoria, British Columbia, Canada
Canada, New Brunswick
Research Site
Moncton, New Brunswick, Canada
Research Site
Saint John, New Brunswick, Canada
Canada, Newfoundland and Labrador
Research Site
St. John's, Newfoundland and Labrador, Canada
Canada, Nova Scotia
Research Site
Halifax, Nova Scotia, Canada
Canada, Ontario
Research Site
Brampton, Ontario, Canada
Research Site
Burlington, Ontario, Canada
Research Site
Cambridge, Ontario, Canada
Research Site
Cornwall, Ontario, Canada
Research Site
Hamilton, Ontario, Canada
Research Site
Kitchener, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Mississauga, Ontario, Canada
Research Site
Newmarket, Ontario, Canada
Research Site
North York, Ontario, Canada
Research Site
Oshawa, Ontario, Canada
Research Site
Ottawa, Ontario, Canada
Research Site
Sarnia, Ontario, Canada
Research Site
Scarborough, Ontario, Canada
Research Site
Sudbury, Ontario, Canada
Research Site
Thunder Bay, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Windsor, Ontario, Canada
Canada, Quebec
Research Site
Chicoutimi, Quebec, Canada
Research Site
Gatineau, Quebec, Canada
Research Site
Greenfield Park, Quebec, Canada
Research Site
Laval, Quebec, Canada
Research Site
Levis, Quebec, Canada
Research Site
Longueuil, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montréal, Quebec, Canada
Research Site
Saint-Charles-Borromee, Quebec, Canada
Research Site
Saint-Georges, Quebec, Canada
Research Site
Saint-Jerome, Quebec, Canada
Research Site
St-Lambert, Quebec, Canada
Research Site
Terrebonne, Quebec, Canada
Research Site
Thetford Mines, Quebec, Canada
Research Site
Val d'Or, Quebec, Canada
Canada, Saskatchewan
Research Site
Saskatoon, Saskatchewan, Canada
Canada
Research Site
Quebec, Canada
Chile
Research Site
Temuco, Santiago, Chile
Research Site
Vina del Mar, V Region, Chile
Research Site
Rancagua, VI Region, Chile
Research Site
Osorno, X Region, Chile
Research Site
Concepcion, Chile
Research Site
Santiago, Chile
Research Site
Santiago Centro, Chile
Research Site
Temuco, Chile
Research Site
Vina del Mar, Chile
China, Beijing
Research Site
Beijing, Beijing, China
China, Hubei
Research Site
Hankou,Wuhan, Hubei, China
China, Hunan
Research Site
Changsha, Hunan, China
China, Jiangsu
Research Site
Nanjing, Jiangsu, China
China, Liaoning
Research Site
Shengyang, Liaoning, China
Research Site
Shenyang, Liaoning, China
China
Research Site
Beijing, China
Research Site
Chongqing, China
Research Site
Guang Zhou, China
Research Site
Guangzhou, China
Research Site
Hang Zhou, China
Research Site
Lanzhou, China
Research Site
Shanghai, China
Research Site
Taiyuan, China
Research Site
Xi'an city, China
Colombia
Research Site
Medellín, Antioquia, Colombia
Research Site
Medillin, Antioquia, Colombia
Research Site
Barranquilla, Atlántico, Colombia
Research Site
Cartagena, Bolívar, Colombia
Research Site
Manizales, Caldas, Colombia
Research Site
Bogota, Cundinamarca, Colombia
Research Site
Bogotá D.C., Cundinamarca, Colombia
Research Site
Cali, Valle, Colombia
Research Site
Armenia, Colombia
Research Site
Barranquilla, Colombia
Research Site
Bogota, Colombia
Research Site
Bucaramanga, Colombia
Research Site
Cartegena, Colombia
Research Site
Medellin, Colombia
Czech Republic
Research Site
Brno, CZ, Czech Republic
Research Site
Brno, Czech Republic
Research Site
Caslav, Czech Republic
Research Site
Ceska Lipa, Czech Republic
Research Site
Cesky Krumlov, Czech Republic
Research Site
Chomutov, Czech Republic
Research Site
Havirov, Czech Republic
Research Site
Kromeriz, Czech Republic
Research Site
Kyjov, Czech Republic
Research Site
Liberec, Czech Republic
Research Site
Marianske Lazne, Czech Republic
Research Site
Ostrava, Czech Republic
Research Site
Ostrava-Poruba, Czech Republic
Research Site
Ostrava-Vitkovice, Czech Republic
Research Site
Pelhrimov, Czech Republic
Research Site
Praha 2, Czech Republic
Research Site
Praha 5, Czech Republic
Research Site
Praha 6, Czech Republic
Research Site
Pribram, Czech Republic
Research Site
Slany, Czech Republic
Research Site
Teplice, Czech Republic
Research Site
Usti nad Labem, Czech Republic
Research Site
Usti nad Orlici, Czech Republic
Research Site
Znojmo, Czech Republic
France
Research Site
ABBEVILLE cedex, France
Research Site
Albi, France
Research Site
Angers, France
Research Site
ANGERS Cedex 9, France
Research Site
Avignon Cedex, France
Research Site
Bayonne, France
Research Site
Cannes, France
Research Site
Creteil, France
Research Site
Dijon, France
Research Site
Jossigny, France
Research Site
La Rochelle Cedex, France
Research Site
Le Chesnay, France
Research Site
Le Coudray Cedex, France
Research Site
Limoges Cedex, France
Research Site
MARSEILLE Cedex 5, France
Research Site
Metz Cedex 1, France
Research Site
NICE Cedex 01, France
Research Site
NIMES Cedex 9, France
Research Site
Orléans Cedex 2, France
Research Site
Paris, France
Research Site
Pessac, France
Research Site
Poitiers, France
Research Site
Toulouse Cedex, France
Research Site
TOURCOING cedex, France
Germany
Research Site
Bad Nauheim, Hessen, Germany
Research Site
Mainz, Hessen, Germany
Research Site
Bad Krozingen, Germany
Research Site
Bad Mergentheim, Germany
Research Site
Berlin, Germany
Research Site
Bielefeld, Germany
Research Site
Coburg, Germany
Research Site
Deggingen, Germany
Research Site
Dortmund, Germany
Research Site
Dresden, Germany
Research Site
Essen, Germany
Research Site
Esslingen, Germany
Research Site
Frankfurt, Germany
Research Site
Hamburg, Germany
Research Site
Heidelberg, Germany
Research Site
Kassel, Germany
Research Site
Kiel, Germany
Research Site
Leipzig, Germany
Research Site
Limburg, Germany
Research Site
Ludwigshafen, Germany
Research Site
Lübeck, Germany
Research Site
Mainz, Germany
Research Site
Mönchengladbach, Germany
Research Site
Ulm, Germany
Research Site
Warendorf, Germany
Research Site
Witten, Germany
Hungary
Research Site
Ballasagyarmat, Hungary
Research Site
Budapest, Hungary
Research Site
Békéscsaba, Hungary
Research Site
Cegléd, Hungary
Research Site
Debrecen, Hungary
Research Site
Eger, Hungary
Research Site
Gyula, Hungary
Research Site
Kalocsa, Hungary
Research Site
Kecskemét, Hungary
Research Site
Mosonmagyaróvár, Hungary
Research Site
Nyíregyháza, Hungary
Research Site
Pécs, Hungary
Research Site
Sopron, Hungary
Research Site
Szeged, Hungary
Research Site
Szekszárd, Hungary
Research Site
Szolnok, Hungary
Research Site
Székesfehérvár, Hungary
Research Site
Zalaegerszeg, Hungary
Italy
Research Site
Bari, BA, Italy
Research Site
Benevento, BN, Italy
Research Site
Brescia, BS, Italy
Research Site
S Maria Capua Vetere, CE, Italy
Research Site
Sessa Aurunca, CE, Italy
Research Site
Catania, CT, Italy
Research Site
Genova, GE, Italy
Research Site
San Remo, IM, Italy
Research Site
Lucca, LU, Italy
Research Site
Vimercate, MB, Italy
Research Site
Legnano, MI, Italy
Research Site
Milano, MI, Italy
Research Site
Rozzano, MI, Italy
Research Site
Carpi, MO, Italy
Research Site
Massa, MS, Italy
Research Site
Pescara, PE, Italy
Research Site
Perugia, PG, Italy
Research Site
Pisa, PI, Italy
Research Site
Parma, PR, Italy
Research Site
Pavia, PV, Italy
Research Site
Reggio Emilia, RE, Italy
Research Site
Albano Laziale, Roma, Italy
Research Site
Siena, SI, Italy
Research Site
Sassari, SS, Italy
Research Site
Napoli, Italy
Research Site
Osio Sotto frazione di Zingoni, Italy
Research Site
Roma, Italy
Research Site
Sorrento NA, Italy
Japan
Research Site
Funabashi-shi, Chiba, Japan
Research Site
Kamogawa-shi, Chiba, Japan
Research Site
Kisarazu-shi, Chiba, Japan
Research Site
Imabari-shi, Ehime, Japan
Research Site
Matsuyama-shi, Ehime, Japan
Research Site
Fukui-shi, Fukui, Japan
Research Site
Koriyama-shi, Fukushima, Japan
Research Site
Gifu-shi, Gifu, Japan
Research Site
Maebashi-shi, Gunma, Japan
Research Site
Takasaki-shi, Gunma, Japan
Research Site
Kure-shi, Hiroshima, Japan
Research Site
Sapporo-shi, Hokkaido, Japan
Research Site
Tomakomai-shi, Hokkaido, Japan
Research Site
Amagasaki-shi, Hyogo, Japan
Research Site
Himeji-shi, Hyogo, Japan
Research Site
Takarazuka-shi, Hyogo, Japan
Research Site
Kanazawa-shi, Ishikawa, Japan
Research Site
Sakaide-shi, Kagawa, Japan
Research Site
Isehara-shi, Kanagawa, Japan
Research Site
Sagamihara-shi, Kanagawa, Japan
Research Site
Yokohama-shi, Kanagawa, Japan
Research Site
Kumamoto-shi, Kumamoto, Japan
Research Site
Yatsushiro-shi, Kumamoto, Japan
Research Site
Kyoto-shi, Kyoto, Japan
Research Site
Miyazaki-shi, Miyazaki, Japan
Research Site
Matsumoto-shi, Nagano, Japan
Research Site
Suwa-shi, Nagano, Japan
Research Site
Ueda-shi, Nagano, Japan
Research Site
Beppu-shi, Oita, Japan
Research Site
Daito-shi, Osaka, Japan
Research Site
Kawachinagano-shi, Osaka, Japan
Research Site
Osaka-shi, Osaka, Japan
Research Site
Sakai-shi, Osaka, Japan
Research Site
Takatsuki-shi, Osaka, Japan
Research Site
Toyonaka-shi, Osaka, Japan
Research Site
Saga-shi, Saga, Japan
Research Site
Saitama-shi, Saitama, Japan
Research Site
Sayama-shi, Saitama, Japan
Research Site
Wako-shi, Saitama, Japan
Research Site
Kusatsu-shi, Shiga, Japan
Research Site
Matsue-shi, Shimane, Japan
Research Site
Hamamatsu-shi, Shizuoka, Japan
Research Site
Shimada-shi, Shizuoka, Japan
Research Site
Shizuoka-shi, Shizuoka, Japan
Research Site
Komatsushima-shi, Tokushima, Japan
Research Site
Akishima-shi, Tokyo, Japan
Research Site
Chuo-ku, Tokyo, Japan
Research Site
Meguro-ku, Tokyo, Japan
Research Site
Shinagawa-ku, Tokyo, Japan
Research Site
Wakayama-shi, Wakayama, Japan
Korea, Republic of
Research Site
Jeonju, Chonbuk, Korea, Republic of
Research Site
Cheongju, Chungcheongbukdo, Korea, Republic of
Research Site
Wonju-si, Gangwon-do, Korea, Republic of
Research Site
Bucheon-si, Gyeonggi-do, Korea, Republic of
Research Site
Seongnam-si, Gyeonggi-do, Korea, Republic of
Research Site
Suwon-si, Gyeonggi-do, Korea, Republic of
Research Site
Uijeongbu, Gyeonggi-do, Korea, Republic of
Research Site
Busan, Korea, Republic of
Research Site
Daegu, Korea, Republic of
Research Site
Daejeon, Korea, Republic of
Research Site
Gwangju, Korea, Republic of
Research Site
Seoul, Korea, Republic of
Netherlands
Research Site
Almere, Netherlands
Research Site
Amersfoort, Netherlands
Research Site
Amsterdam, Netherlands
Research Site
Arnhem, Netherlands
Research Site
Beverwijk, Netherlands
Research Site
Breda, Netherlands
Research Site
Delft, Netherlands
Research Site
Den Haag, Netherlands
Research Site
Den Helder, Netherlands
Research Site
Deventer, Netherlands
Research Site
Drachten, Netherlands
Research Site
EDE, Netherlands
Research Site
Eindhoven, Netherlands
Research Site
Goes, Netherlands
Research Site
Groningen, Netherlands
Research Site
Hardenberg, Netherlands
Research Site
Heerenveen, Netherlands
Research Site
Heerlen, Netherlands
Research Site
Helmond, Netherlands
Research Site
Hilversum, Netherlands
Research Site
Hoofddorp, Netherlands
Research Site
Hoogeveen, Netherlands
Research Site
Leiderdorp, Netherlands
Research Site
Maastricht, Netherlands
Research Site
Nieuwegein, Netherlands
Research Site
Nijmegen, Netherlands
Research Site
OSS, Netherlands
Research Site
Roosendaal, Netherlands
Research Site
Rotterdam, Netherlands
Research Site
Shertogenbosch, Netherlands
Research Site
Sittardgeleen, Netherlands
Research Site
Sneek, Netherlands
Research Site
Tiel, Netherlands
Research Site
Tilburg, Netherlands
Research Site
Veldhoven, Netherlands
Research Site
Vlaardingen, Netherlands
Norway
Research Site
Bergen, Norway
Research Site
Bodo, Norway
Research Site
Bodø, Norway
Research Site
Flekkefjord, Norway
Research Site
Hamar, Norway
Research Site
Levanger, Norway
Research Site
Lillehammer, Norway
Research Site
Nesttun, Norway
Research Site
Oslo, Norway
Research Site
Skien, Norway
Research Site
Tromsø, Norway
Research Site
Tynset, Norway
Peru
Research Site
Trujillo, La Libertad, Peru
Research Site
San Borja, Lima, Peru
Research Site
Arequipa, Peru
Research Site
Callao, Peru
Research Site
Lima, Peru
Philippines
Research Site
Lipa City, Batangas, Philippines
Research Site
San Juan, Metro Manila, Philippines
Research Site
Quezon City, Sta Cruz Manila, Philippines
Research Site
Cebu City, Philippines
Research Site
Fuente Osmena Cebu City, Philippines
Research Site
Iloilo City, Philippines
Research Site
Las Pinas City, Philippines
Research Site
Mandaluyong City, Philippines
Research Site
Manila, Philippines
Research Site
Pasig City, Philippines
Research Site
Quezon, Philippines
Research Site
Quezon City, Philippines
Poland
Research Site
Białystok, Poland
Research Site
Bielsko Biala, Poland
Research Site
Bydgoszcz, Poland
Research Site
Chorzow, Poland
Research Site
Gdańsk, Poland
Research Site
Gdynia, Poland
Research Site
Giżycko, Poland
Research Site
Kraków, Poland
Research Site
Legnica, Poland
Research Site
Lubin, Poland
Research Site
Nowa Sól, Poland
Research Site
Olsztyn, Poland
Research Site
Opole, Poland
Research Site
Ostrów Mazowiecka, Poland
Research Site
Oława, Poland
Research Site
Piotrkow, Poland
Research Site
Poznan, Poland
Research Site
Płock, Poland
Research Site
Skierniewice, Poland
Research Site
Sobótka, Poland
Research Site
Sokolka, Poland
Research Site
Szczecin, Poland
Research Site
Tarnów, Poland
Research Site
Torun, Poland
Research Site
Toruń, Poland
Research Site
Warszawa, Poland
Research Site
Wrocław, Poland
Research Site
Włocławek, Poland
Research Site
Łańcut, Poland
Research Site
Łódź, Poland
Research Site
Łęczna, Poland
Romania
Research Site
Pitesti, Arges, Romania
Research Site
Cluj Napoca, Cluj, Romania
Research Site
Tg. Mures, Mures, Romania
Research Site
Bacau, Romania
Research Site
Braila, Romania
Research Site
Brasov, Romania
Research Site
Bucharest, Romania
Research Site
Bucuresti, Romania
Research Site
Buzau, Romania
Research Site
Craiova, Romania
Research Site
Deva, Romania
Research Site
Focsani, Romania
Research Site
Iasi, Romania
Research Site
Sibiu, Romania
Research Site
Suceava, Romania
Research Site
Timisoara, Romania
Russian Federation
Research Site
Moscow, Russia, Russian Federation
Research Site
Ekaterinburg, Russian Federation
Research Site
Gatchina, Russian Federation
Research Site
Kazan, Russian Federation
Research Site
Krasnodar, Russian Federation
Research Site
Moscow, Russian Federation
Research Site
Nizhnii Novgorod, Russian Federation
Research Site
Novosibirsk, Russian Federation
Research Site
Perm, Russian Federation
Research Site
Saint Petersburg, Russian Federation
Research Site
Saint-Petersburg, Russian Federation
Research Site
Saratov, Russian Federation
Research Site
St.-Petersburg, Russian Federation
Research Site
St.-Petersburg,, Russian Federation
Research Site
St.Petersburg, Russian Federation
Research Site
StPetersburg, Russian Federation
Research Site
Vladikavkaz, Russian Federation
Research Site
Volgograd, Russian Federation
Slovakia
Research Site
Banska Bystrica, Slovakia
Research Site
Bardejov, Slovakia
Research Site
Bratislava, Slovakia
Research Site
Komarno, Slovakia
Research Site
Kosice, Slovakia
Research Site
Liptovsky Hradok, Slovakia
Research Site
Liptovsky Mikulas, Slovakia
Research Site
Martin, Slovakia
Research Site
Nitra, Slovakia
Research Site
Partizanske, Slovakia
Research Site
Piestany, Slovakia
Research Site
Povazska Bystrica, Slovakia
Research Site
Presov, Slovakia
Research Site
Ruzomberok, Slovakia
Research Site
Trnava, Slovakia
Research Site
Zilina, Slovakia
South Africa
Research Site
Gatesville, Cape Town, South Africa
Research Site
Bloemfontein, Free State, South Africa
Research Site
Kempron Park, Gauteng, South Africa
Research Site
Pretoria, Gauteng, South Africa
Research Site
Soweto, Gauteng, South Africa
Research Site
Durban, KwaZulu Natal, South Africa
Research Site
Panorama, W Cape, South Africa
Research Site
Parow, W Cape, South Africa
Research Site
Cape Town, Western Cape, South Africa
Research Site
Somerset West, Western Cape, South Africa
Research Site
Alberton, South Africa
Research Site
Cape Town, South Africa
Research Site
Centurion, South Africa
Research Site
Durban, South Africa
Research Site
George, South Africa
Research Site
Johannesburg, South Africa
Research Site
Pretoria, South Africa
Research Site
Worcester, South Africa
Spain
Research Site
Almeria, Andalucia, Spain
Research Site
Málaga, Andalucía, Spain
Research Site
Sevilla, Andalucía, Spain
Research Site
Aviles, Asturias, Spain
Research Site
Oviedo, Asturias, Spain
Research Site
Barcelona, Cataluña, Spain
Research Site
Hospitalet de Llobregat(Barcel, Cataluña, Spain
Research Site
Sabadell, Cataluña, Spain
Research Site
Madrid, Comunida de Madrid, Spain
Research Site
Madrid, Comunidad de Madrid, Spain
Research Site
Majadahonda, Comunidad de Madrid, Spain
Research Site
San Sebastian de los Reyes, Comunidad de Madrid, Spain
Research Site
Valencia, Comunidad Valenciana, Spain
Research Site
Don Benito (Badajoz), Extremadura, Spain
Research Site
Santiago(A Coruña), Galicia, Spain
Research Site
Palma de Mallorca, Islas Baleares, Spain
Research Site
Bilbao, País Vasco, Spain
Sweden
Research Site
Eksjö, Sweden
Research Site
Göteborg, Sweden
Research Site
Jönköping, Sweden
Research Site
Linkoping, Sweden
Research Site
Ljungby, Sweden
Research Site
Lund, Sweden
Research Site
Molndal, Sweden
Research Site
Stockholm, Sweden
Research Site
Sundsvall, Sweden
Research Site
Umea, Sweden
Research Site
Västerås, Sweden
Research Site
Örebro, Sweden
Research Site
Östersund, Sweden
Turkey
Research Site
Ankara, Turkiye, Turkey
Research Site
Adana, Turkey
Research Site
Ankara, Turkey
Research Site
Istanbul, Turkey
Research Site
Izmir, Turkey
Research Site
Malatya, Turkey
Research Site
Mersin, Turkey
Ukraine
Research Site
Dnepropetrovsk, Ukraine
Research Site
Donetsk, Ukraine
Research Site
Kharkiv, Ukraine
Research Site
Kharkov, Ukraine
Research Site
Kiev, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Lviv, Ukraine
Research Site
Uzhgorod, Ukraine
Research Site
Vinnitsa, Ukraine
Research Site
Zaporozye, Ukraine
United Kingdom
Research Site
Ely, Cambridgeshire, United Kingdom
Research Site
Brighton, East Sussex, United Kingdom
Research Site
Airdrie, Lanarkshire, United Kingdom
Research Site
Antrim, Northern Ireland, United Kingdom
Research Site
Belfast, Northern Ireland, United Kingdom
Research Site
Blackpool, United Kingdom
Research Site
Bournemouth, United Kingdom
Research Site
Bristol, United Kingdom
Research Site
Coventry, United Kingdom
Research Site
Dundee, United Kingdom
Research Site
East Kilbride, United Kingdom
Research Site
Hastings, United Kingdom
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Middlesborough, United Kingdom
Research Site
Northampton, United Kingdom
Research Site
Nottingham, United Kingdom
Research Site
Peterborough, United Kingdom
Research Site
Rotherham, United Kingdom
Research Site
Sheffield, United Kingdom
Research Site
Swansea, United Kingdom
Research Site
Torquay, United Kingdom
Research Site
York, United Kingdom
Sponsors and Collaborators
AstraZeneca
Investigators
Study Chair: Eugene Braunwald, MD TIMI Study Group
Principal Investigator: Marc Sabatine, MD, MPh TIMI Study Group
  More Information

No publications provided by AstraZeneca

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: AstraZeneca
ClinicalTrials.gov Identifier: NCT01225562     History of Changes
Other Study ID Numbers: D5132C00001, 2009-017242-30
Study First Received: July 9, 2010
Last Updated: June 3, 2014
Health Authority: Argentina: Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica
Australia: Department of Health and Ageing Therapeutic Goods Administration
Belgium: Ministry of Social Affairs, Public Health and the Environment
Brazil: National Health Surveillance Agency
Bulgaria: Bulgarian Drug Agency
Canada: Health Canada
Chile: Instituto de Salud Pública de Chile
China: Food and Drug Administration
Colombia: INVIMA Instituto Nacional de Vigilancia de Medicamentos y Alimentos
Czech Republic: State Institute for Drug Control
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Germany: Federal Institute for Drugs and Medical Devices
Hungary: National Institute of Pharmacy
Italy: Ethics Committee
Japan: Ministry of Health, Labor and Welfare
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Norway: Norwegian Medicines Agency
Peru: Instituto Nacional de Salud
Philippines: Bureau of Food and Drugs
Poland: Office for Registration of Medicinal Products, Medical Devices and Biocidal Products
Romania: National Medicines Agency
Russia: Pharmacological Committee, Ministry of Health
Slovakia: State Institute for Drug Control
South Africa: Medicines Control Council
South Korea: Korea Food and Drug Administration (KFDA)
Spain: Agencia Española de Medicamentos y Productos Sanitarios
Sweden: Medical Products Agency
Turkey: Ministry of Health
Ukraine: Ministry of Health
United States: Food and Drug Administration
United Kingdom: Medicines and Healthcare Products Regulatory Agency

Keywords provided by AstraZeneca:
Heart attack
Heart Disease
Acute coronary syndrome
ACS
Cardiovascular Disease

Additional relevant MeSH terms:
Death
Infarction
Myocardial Infarction
Stroke
Cerebral Infarction
Pathologic Processes
Ischemia
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Brain Infarction
Brain Ischemia
Ticagrelor
Purinergic P2Y Receptor Antagonists
Purinergic P2 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on July 24, 2014