Trial record 1 of 1 for:    RTOG 1010
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Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01196390
First received: September 4, 2010
Last updated: June 23, 2014
Last verified: March 2014
  Purpose

This randomized phase III trial studies how well radiation therapy, paclitaxel, and carboplatin with or without trastuzumab work in treating patients with esophageal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether giving radiation therapy and combination chemotherapy together with or without trastuzumab is more effective in treating esophageal cancer.


Condition Intervention Phase
Adenocarcinoma of the Esophagus
Adenocarcinoma of the Gastroesophageal Junction
Stage IB Esophageal Cancer
Stage IIA Esophageal Cancer
Stage IIB Esophageal Cancer
Stage IIIA Esophageal Cancer
Stage IIIB Esophageal Cancer
Radiation: radiation therapy
Drug: paclitaxel
Drug: carboplatin
Biological: trastuzumab
Procedure: therapeutic conventional surgery
Other: laboratory biomarker analysis
Procedure: quality-of-life assessment
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Trial Evaluating The Addition Of Trastuzumab To Trimodality Treatment Of Her2-Overexpressing Esophageal Adenocarcinoma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Disease-free survival (DFS) [ Time Frame: From the date of randomization to the date of first failure or last follow-up, assessed up to 8 years ] [ Designated as safety issue: No ]
    DFS will be estimated by the Kaplan-Meier method. The distribution of DFS estimates between the 2 arms will be compared using the log rank test. The Cox proportional hazard regression model will be used to analyze the effects of factors, in addition to treatment, that may be associated with DFS.


Secondary Outcome Measures:
  • Pathologic complete response [ Time Frame: Within 4 weeks after surgical resection ] [ Designated as safety issue: No ]
    Pathologic complete response is defined as no viable residual tumor cells.

  • Overall survival (OS) [ Time Frame: From the date of randomization to the date of first failure or last follow-up, assessed up to 8 years ] [ Designated as safety issue: No ]
    OS will be estimated by the Kaplan-Meier method. The distribution of OS estimates between the 2 arms will be compared using the log rank test. The Cox proportional hazard regression model will be used to analyze the effects of factors, in addition to treatment, that may be associated with OS.

  • Adverse events [ Time Frame: From the start of chemoradiation up to the earlier date of surgery or 6 weeks after completion of chemoradiation ] [ Designated as safety issue: Yes ]
    Assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0

  • Health-related quality of life (QOL) as measured by FACT-E [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
    Distributions of QOL data collection patterns over all collection points in each treatment arm will be described. To inspect the missing data mechanism for each tool, at least a graphical method will be used.

  • Quality-adjusted survival [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
    The EQ-5D will be used to assess quality-adjusted survival. Quality-adjusted survival is calculated as the weighted sum of different time in different health states added up to a total quality-adjusted survival time [U=sum of quality (qi) of health states K times the duration (si) spent in each health state].

  • Molecular correlates of efficacy [ Time Frame: Up to 8 years ] [ Designated as safety issue: No ]
  • Predictors of cardiotoxicity [ Time Frame: Up to 8 years ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 480
Study Start Date: December 2010
Estimated Primary Completion Date: August 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (radiotherapy, chemotherapy, trastuzumab)
Patients undergo radiotherapy once daily 5 days a week for 5.5 weeks. Patients also receive paclitaxel IV over 60 minutes and carboplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36 and trastuzumab IV over 30-90 minutes on days 1, 8, 15, 22, 29, 36, and 57. Within 5-8 weeks after completion of radiotherapy, all patients undergo surgery. Beginning 21-56 days after surgery, patients receive trastuzumab IV over 30-90 minutes. Treatment repeats every 21 days for 13 courses in the absence of disease progression or unacceptable toxicity.
Radiation: radiation therapy
Undergo radiation therapy
Other Names:
  • irradiation
  • radiotherapy
  • therapy, radiation
Drug: paclitaxel
Given IV
Other Names:
  • Anzatax
  • Asotax
  • TAX
  • Taxol
Drug: carboplatin
Given IV
Other Names:
  • Carboplat
  • CBDCA
  • JM-8
  • Paraplat
  • Paraplatin
Biological: trastuzumab
Given IV
Other Names:
  • anti-c-erB-2
  • Herceptin
  • MOAB HER2
Procedure: therapeutic conventional surgery
Undergo surgery
Other: laboratory biomarker analysis
Correlative studies
Procedure: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Experimental: Arm II (radiotherapy and chemotherapy)
Patients undergo radiotherapy once daily 5 days a week for 5.5 weeks. Patients also receive paclitaxel IV over 60 minutes and carboplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36.
Radiation: radiation therapy
Undergo radiation therapy
Other Names:
  • irradiation
  • radiotherapy
  • therapy, radiation
Drug: paclitaxel
Given IV
Other Names:
  • Anzatax
  • Asotax
  • TAX
  • Taxol
Drug: carboplatin
Given IV
Other Names:
  • Carboplat
  • CBDCA
  • JM-8
  • Paraplat
  • Paraplatin
Procedure: therapeutic conventional surgery
Undergo surgery
Other: laboratory biomarker analysis
Correlative studies
Procedure: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pathologically confirmed primary adenocarcinoma of the esophagus that involves the mid (up to 25 cm), distal, or esophagogastric junction; the cancer may involve the stomach up to 5 cm
  • Endoscopy with biopsy
  • PRIOR TO STEP 1 REGISTRATION BUT WITHIN 56 DAYS PRIOR TO STEP 2 REGISTRATION
  • Intent to submit tissue for central HER2 testing
  • Stage T1N1-2, T2-3N0-2, according to the American Joint Committee on Cancer (AJCC) 7th edition staging, based on the following minimum diagnostic work-up:

    • Chest/abdominal/pelvic computed tomography (CT) or whole-body positron emission tomography (PET)/CT (NOTE: if CT is performed at this time point, whole-body PET/CT will be required prior to step 2 registration; PET/CT of skull base to mid-thigh is acceptable) (NOTE: if adenopathy is noted on CT or whole-body PET/CT scan, an endoscopic ultrasound is not required prior to STEP 2 registration as long as adequate tissue has been obtained for central HER2 testing)
    • Patients may have regional adenopathy including para-esophageal, gastric, gastrohepatic and celiac nodes; if celiac adenopathy is present, it must be =< 2 cm
    • Patients with tumors at the level of the carina or above must undergo bronchoscopy to exclude fistula
  • Zubrod performance status 0-2
  • Absolute neutrophil count (ANC) >= 1,500 cells/mm³
  • Platelets >=100,000 cells/mm³
  • Hemoglobin >= 8.0 g/dL (note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dL is acceptable)
  • Creatinine =< 2 times upper limit of normal
  • Bilirubin =< 1.5 times upper limit of normal
  • Aspartate aminotransferase (AST) =< 3.0 times upper limit of normal
  • For women of childbearing potential, a negative serum or urine pregnancy test
  • Patients must sign a study-specific informed consent prior to study entry
  • CONDITIONS FOR PATIENT ELIGIBILITY PRIOR TO STEP 2 REGISTRATION (HER2-POSITIVE PATIENTS ONLY)
  • HER2 expressing adenocarcinoma of the esophagus centrally
  • Surgical consultation to confirm that patient will be able to undergo curative resection after completion of chemoradiation within 56 days prior to step 2 registration
  • Radiation oncology consultation to confirm that disease can be encompassed in a radiotherapy field within 56 days prior to step 2 registration
  • Consultation with a medical oncologist within 56 days prior to step 2 registration
  • Stage T1N1-2, T2-3N0-2, according to the AJCC 7th edition staging, based upon the following minimum diagnostic work-up:

    • History/physical examination, with documentation of the patient's weight, within 14 days prior to step 2 registration
    • Whole-body PET/CT scan within 56 days prior to step 2 registration (if only CT performed prior to step 1 registration)
    • Endoscopic ultrasound within 56 days prior to step 2 registration, unless the patient is found to have adenopathy per CT or whole-body PET/CT scan
    • Electrocardiogram (EKG) within 56 days prior to step 2 registration
    • Serum creatinine =< 2 x the upper limit or normal within 14 days prior to step 2 registration
  • Zubrod performance status 0-2 within 14 days prior to step 2 registration
  • For women of childbearing potential, a negative serum pregnancy test within 14 days prior to step 2 registration
  • Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal by cardiac echocardiogram (echo) or multi gated acquisition (MUGA) scan within 56 days prior to step 2 registration
  • Women of childbearing potential and sexually active male participants must agree to practice adequate contraception while on study and for at least 60 days following the last dose of chemotherapy or trastuzumab

Exclusion Criteria:

  • Patients with cervical esophageal carcinoma
  • Patients with T1N0 disease, T4 disease, and proximal esophageal cancers (15-24 cm)
  • Prior systemic chemotherapy for esophageal cancer; note that prior chemotherapy for a different cancer is allowable
  • Prior radiation therapy for esophageal cancer or prior chest radiotherapy
  • Prior anthracycline or taxane
  • Evidence of tracheoesophageal fistula or invasion into the trachea or major bronchi
  • Prior invasive malignancy (except non-melanomatous skin cancer), unless disease free for a minimum of 2 years (e.g., carcinoma in situ of the breast, oral cavity, or cervix are permissible)
  • Medical contraindications to esophagectomy
  • Prior therapy with any agent targeting the HER2 pathway or human epidermal growth factor receptor 1 (HER1) (epidermal growth factor receptor [EGFR]) pathway
  • Prior therapy with trastuzumab
  • Prior allergic reaction to the study drugs involved in this protocol or to a monoclonal antibody
  • Previous history of congestive heart failure
  • Severe, active comorbidity, defined as follows:

    • Unstable angina in the last 6 months
    • Transmural myocardial infarction within the last 6 months
    • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
    • Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition; note, however that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immunocompromised patients
  • Pregnant or nursing women or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01196390

  Hide Study Locations
Locations
United States, Alabama
The Kirklin Clinic at Acton Road Recruiting
Birmingham, Alabama, United States, 35243
Contact: Rojymon Jacob    205-934-0309      
Principal Investigator: Rojymon Jacob         
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Rojymon Jacob    205-934-0309      
Principal Investigator: Rojymon Jacob         
Providence Hospital Terminated
Mobile, Alabama, United States, 36608
United States, Arizona
Mayo Clinic Hospital Active, not recruiting
Phoenix, Arizona, United States, 85054
Mayo Clinic in Arizona Active, not recruiting
Scottsdale, Arizona, United States, 85259
University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724
Contact: Krisha J. Howell    520-626-9008      
Principal Investigator: Krisha J. Howell         
United States, California
Mills - Peninsula Hospitals Recruiting
Burlingame, California, United States, 94010
Contact: Ari D. Baron    415-600-1182    SchmidtJ@cpmcri.org   
Principal Investigator: Ari D. Baron         
Enloe Medical Center Recruiting
Chico, California, United States, 95926
Contact: Grace E. Yuh    530-332-3808      
Principal Investigator: Grace E. Yuh         
University of Southern California/Norris Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Heinz-Josef Lenz    323-865-0451      
Principal Investigator: Heinz-Josef Lenz         
Cedars-Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Richard Tuli    310-423-8965      
Principal Investigator: Richard Tuli         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Heinz-Josef Lenz    323-865-0451      
Principal Investigator: Heinz-Josef Lenz         
Kaiser Permanente Oakland-Broadway Recruiting
Oakland, California, United States, 94611
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
University of California Medical Center At Irvine-Orange Campus Recruiting
Orange, California, United States, 92868
Contact: Chaitali S. Nangia    877-827-8839    ucstudy@uci.edu   
Principal Investigator: Chaitali S. Nangia         
Kaiser Permanente-Rancho Cordova Cancer Center Recruiting
Rancho Cardova, California, United States, 95670
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
Rohnert Park Cancer Center Recruiting
Rohnert Park, California, United States, 94928
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
The Permanente Medical Group-Roseville Radiation Oncology Recruiting
Roseville, California, United States, 95678
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
Sutter General Hospital Recruiting
Sacramento, California, United States, 95816
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
South Sacramento Cancer Center Recruiting
Sacramento, California, United States, 95823
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
University of California at Davis Cancer Center Withdrawn
Sacramento, California, United States, 95817
Saint Helena Hospital Recruiting
Saint Helena, California, United States, 94574
Contact: David J. Tate    707-967-3698      
Principal Investigator: David J. Tate         
Kaiser Permanente Radiation Oncology Cancer Treatment Center Recruiting
Santa Clara, California, United States, 95051
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
Kaiser Permanente Cancer Treatment Center Recruiting
South San Francisco, California, United States, 94080
Contact: Samantha A. Seaward    626-564-3455      
Principal Investigator: Samantha A. Seaward         
Stanford University Hospitals and Clinics Active, not recruiting
Stanford, California, United States, 94305
Sutter Solano Medical Center Recruiting
Vallejo, California, United States, 94589
Contact: Ari D. Baron    415-600-1182    SchmidtJ@cpmcri.org   
Principal Investigator: Ari D. Baron         
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Eduardo R. Pajon    888-336-8262      
Principal Investigator: Eduardo R. Pajon         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Poudre Valley Radiation Oncology Recruiting
Fort Collins, Colorado, United States, 80528
Contact: Joshua H. Petit    970-482-3328      
Principal Investigator: Joshua H. Petit         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Suburban Medical Center Terminated
Thornton, Colorado, United States, 80229
Rocky Mountain Cancer Centers-Thornton Recruiting
Thornton, Colorado, United States, 80260
Contact: Eduardo R. Pajon    888-336-8262      
Principal Investigator: Eduardo R. Pajon         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Middlesex Hospital Recruiting
Middletown, Connecticut, United States, 06457
Contact: Susanna Hong    860-358-2058      
Principal Investigator: Susanna Hong         
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Bryan W. Chang    203-785-5702      
Principal Investigator: Bryan W. Chang         
William Backus Hospital Recruiting
Norwich, Connecticut, United States, 06360
Contact: Dennis E. Slater    860-886-8362      
Principal Investigator: Dennis E. Slater         
United States, Delaware
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Adam Raben    302-733-6227      
Principal Investigator: Adam Raben         
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Adam Raben    302-733-6227      
Principal Investigator: Adam Raben         
United States, Florida
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Robert J. Sollaccio    407-303-5623      
Principal Investigator: Robert J. Sollaccio         
Robert and Carol Weissman Cancer Center at Martin Health Recruiting
Stuart, Florida, United States, 34994
Contact: Guillermo Abesada-Terk    772-288-5858ext4      
Principal Investigator: Guillermo Abesada-Terk         
United States, Georgia
Emory University/Winship Cancer Institute Withdrawn
Atlanta, Georgia, United States, 30322
Grady Health System Withdrawn
Atlanta, Georgia, United States, 30303
Piedmont Hospital Recruiting
Atlanta, Georgia, United States, 30309
Contact: Adam W. Nowlan    404-425-7943    phri@piedmont.org   
Principal Investigator: Adam W. Nowlan         
Piedmont Fayette Hospital Recruiting
Fayetteville, Georgia, United States, 30214
Contact: Adam W. Nowlan    404-425-7943    phri@piedmont.org   
Principal Investigator: Adam W. Nowlan         
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Frank G. Lake    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Frank G. Lake         
Medical Center of Central Georgia Recruiting
Macon, Georgia, United States, 31208
Contact: Frederick M. Schnell    478-633-1226      
Principal Investigator: Frederick M. Schnell         
Saint Joseph's-Candler Health System Recruiting
Savannah, Georgia, United States, 31405
Contact: John A. Pablo    912-819-5704      
Principal Investigator: John A. Pablo         
Memorial Health University Medical Center Recruiting
Savannah, Georgia, United States, 31403
Contact: Aaron W. Pederson    912-350-8568      
Principal Investigator: Aaron W. Pederson         
United States, Idaho
Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
United States, Illinois
Northwest Community Hospital Terminated
Arlington Heights, Illinois, United States, 60005
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Neeta K. Venepalli    312-355-3046      
Principal Investigator: Neeta K. Venepalli         
Northwestern University Active, not recruiting
Chicago, Illinois, United States, 60611
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Ingalls Memorial Hospital Recruiting
Harvey, Illinois, United States, 60426
Contact: Sulochana D. Yalavarthi    708-915-4673    clinicaltrials@ingalls.org   
Principal Investigator: Sulochana D. Yalavarthi         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Bahman Emami    708-226-4357      
Principal Investigator: Bahman Emami         
Advocate Christ Medical Center Withdrawn
Oak Lawn, Illinois, United States, 60453-2699
Memorial Medical Center Active, not recruiting
Springfield, Illinois, United States, 62781-0001
United States, Indiana
Saint Francis Hospital and Health Centers Recruiting
Beech Grove, Indiana, United States, 46107
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Elkhart General Hospital Recruiting
Elkhart, Indiana, United States, 46515
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
Parkview Hospital Randallia Recruiting
Fort Wayne, Indiana, United States, 46805
Contact: Brian K. Chang    260-373-8888    parkviewresearch@parkview.com   
Principal Investigator: Brian K. Chang         
Radiation Oncology Associates PC Recruiting
Fort Wayne, Indiana, United States, 46804
Contact: Brian K. Chang    260-373-8888    parkviewresearch@parkview.com   
Principal Investigator: Brian K. Chang         
Franciscan Saint Francis Health-Indianapolis Recruiting
Indianapolis, Indiana, United States, 46237
Contact: Stephen E. Rubenstein    317-851-2555      
Principal Investigator: Stephen E. Rubenstein         
Michiana Hematology Oncology PC-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
IU Health Ball Memorial Hospital Recruiting
Muncie, Indiana, United States, 47303
Contact: Yunjie X. Lin    765-751-5850    alpatterson@medicalconsultantspc.com   
Principal Investigator: Yunjie X. Lin         
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mercy Hospital Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    319-363-2690      
Principal Investigator: Deborah W. Wilbur         
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Iowa Methodist Medical Center Active, not recruiting
Des Moines, Iowa, United States, 50309
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Mark C. Smith    800-237-1225      
Principal Investigator: Mark C. Smith         
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Centers-Southwest Recruiting
Overland Park, Kansas, United States, 66210
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City CCOP Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
United States, Kentucky
Baptist Health Lexington Active, not recruiting
Lexington, Kentucky, United States, 40503
University of Kentucky Withdrawn
Lexington, Kentucky, United States, 40536
United States, Louisiana
Ochsner Clinic CCOP Withdrawn
New Orleans, Louisiana, United States, 70121
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Jyotsna Fuloria    888-562-4763      
Principal Investigator: Jyotsna Fuloria         
United States, Maine
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Ian J. Bristol    207-396-8090    wrighd@mmc.org   
Principal Investigator: Ian J. Bristol         
United States, Maryland
Greater Baltimore Medical Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Marshall A. Levine    443-849-3706      
Principal Investigator: Marshall A. Levine         
University of Maryland/Greenebaum Cancer Center Recruiting
Baltimore, Maryland, United States, 21201
Contact: Mohan Suntharalingam    800-888-8823      
Principal Investigator: Mohan Suntharalingam         
Peninsula Regional Medical Center Recruiting
Salisbury, Maryland, United States, 21801
Contact: Matthew L. Snyder    866-922-6237      
Principal Investigator: Matthew L. Snyder         
United States, Massachusetts
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: Theodore S. Hong       tshong1@partners.org   
Principal Investigator: Theodore S. Hong         
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Lisa A. Kachnic    617-638-8265      
Principal Investigator: Lisa A. Kachnic         
Brigham and Women's Hospital Active, not recruiting
Boston, Massachusetts, United States, 02115
Massachusetts General Hospital Cancer Center Recruiting
Boston, Massachusetts, United States, 02114
Contact: Theodore S. Hong    877-726-5130      
Principal Investigator: Theodore S. Hong         
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Asa J. Nixon    781-744-8027      
Principal Investigator: Asa J. Nixon         
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Recruiting
Milford, Massachusetts, United States, 01757
Contact: Michael Constantine    215-574-3173      
Principal Investigator: Michael Constantine         
Berkshire Hematology Oncology PC Recruiting
Pittsfield, Massachusetts, United States, 01201
Contact: Harvey Zimbler    413-496-8205    ggero@bhs1.org   
Principal Investigator: Harvey Zimbler         
Dana-Farber/Brigham and Women's Cancer Center at South Shore Recruiting
South Weymouth, Massachusetts, United States, 02190
Contact: Rolf Freter    617-376-6400    koneil@shcpo.shields.com   
Principal Investigator: Rolf Freter         
D'Amour Center for Cancer Care Active, not recruiting
Springfield, Massachusetts, United States, 01107
United States, Michigan
Bixby Medical Center Recruiting
Adrian, Michigan, United States, 49221
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
University of Michigan Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: James A. Hayman    800-865-1125      
Principal Investigator: James A. Hayman         
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Assarian Cancer Center Terminated
Novi, Michigan, United States, 48374-1236
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Providence Hospital Recruiting
Southfield, Michigan, United States, 48075
Contact: Michael J. Kraut    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Michael J. Kraut         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
United States, Minnesota
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel A. Nikcevich    888-203-7267      
Principal Investigator: Daniel A. Nikcevich         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Michael G. Haddock    507-538-7623      
Principal Investigator: Michael G. Haddock         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: James T. Thigpen    601-815-6700      
Principal Investigator: James T. Thigpen         
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson    228-809-5292      
Principal Investigator: James E. Clarkson         
United States, Missouri
Cape Radiation Oncology Terminated
Cape Girardeau, Missouri, United States, 63703
Saint Luke's Hospital Recruiting
Chesterfield, Missouri, United States, 63017
Contact: Donald F. Busiek    314-205-6936      
Principal Investigator: Donald F. Busiek         
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Center - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Kansas City Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Liberty Hospital Recruiting
Liberty, Missouri, United States, 64068
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Phelps County Regional Medical Center Recruiting
Rolla, Missouri, United States, 65401
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Clifford G. Robinson    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Clifford G. Robinson         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Barnes-Jewish West County Hospital Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Clifford G. Robinson    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Clifford G. Robinson         
Siteman Cancer Center-South County Recruiting
Saint Louis, Missouri, United States, 63129
Contact: Clifford G. Robinson    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Clifford G. Robinson         
Saint Louis-Cape Girardeau CCOP Withdrawn
Saint Louis, Missouri, United States, 63141
Siteman Cancer Center - Saint Peters Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Clifford G. Robinson    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Clifford G. Robinson         
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
United States, Montana
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Tien-Shew W. Huang    402-354-5144      
Principal Investigator: Tien-Shew W. Huang         
United States, Nevada
Comprehensive Cancer Centers of Nevada - Central Valley Recruiting
Las Vegas, Nevada, United States, 89169
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: Michael C. Hardacre    775-982-4400      
Principal Investigator: Michael C. Hardacre         
United States, New Hampshire
Concord Hospital Recruiting
Concord, New Hampshire, United States, 03301
Contact: Su K. Metcalfe    800-441-1138      
Principal Investigator: Su K. Metcalfe         
Wentworth-Douglass Hospital Recruiting
Dover, New Hampshire, United States, 03820
Contact: Taylor M. Ortiz    603-740-2150      
Principal Investigator: Taylor M. Ortiz         
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Abraham J. Wu    212-639-7202      
Principal Investigator: Abraham J. Wu         
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: Sucha O. Asbell    856-325-6757      
Principal Investigator: Sucha O. Asbell         
Morristown Memorial Hospital Recruiting
Morristown, New Jersey, United States, 07962
Contact: Mona Karim    973-971-5900      
Principal Investigator: Mona Karim         
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Recruiting
Mount Holly, New Jersey, United States, 08060
Contact: Lemuel S. Ariaratnam    888-847-8823      
Principal Investigator: Lemuel S. Ariaratnam         
UMDNJ - New Jersey Medical School Recruiting
Newark, New Jersey, United States, 07103
Contact: Sabin B. Motwani    732-235-8675      
Principal Investigator: Sabin B. Motwani         
Sparta Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Voichita Bar Ad    215-955-6084      
Principal Investigator: Voichita Bar Ad         
MD Anderson Cancer Center at Cooper-Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Sucha O. Asbell    856-325-6757      
Principal Investigator: Sucha O. Asbell         
United States, New Mexico
University of New Mexico Cancer Center Active, not recruiting
Albuquerque, New Mexico, United States, 87106
United States, New York
Montefiore Medical Center - Moses Campus Recruiting
Bronx, New York, United States, 10467-2490
Contact: Lakshmi Rajdev    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Lakshmi Rajdev         
Memorial Sloan Kettering Cancer Center Commack Recruiting
Commack, New York, United States, 11725
Contact: Abraham J. Wu    212-639-7202      
Principal Investigator: Abraham J. Wu         
Glens Falls Hospital Recruiting
Glens Falls, New York, United States, 12801
Contact: Eric A. Pillemer    518-926-6700      
Principal Investigator: Eric A. Pillemer         
Beth Israel Medical Center Recruiting
New York, New York, United States, 10003
Contact: Peter S. Kozuch    212-844-6286      
Principal Investigator: Peter S. Kozuch         
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Balazs Halmos    212-305-8615      
Principal Investigator: Balazs Halmos         
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Abraham J. Wu    212-639-7202      
Principal Investigator: Abraham J. Wu         
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division Recruiting
New York, New York, United States, 10025
Contact: Peter S. Kozuch    212-844-6286      
Principal Investigator: Peter S. Kozuch         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Memorial Sloan-Kettering Cancer Center Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Abraham J. Wu    212-639-7202      
Principal Investigator: Abraham J. Wu         
Memorial Sloan-Kettering Cancer Center at Sleepy Hallow Recruiting
Sleepy Hollow, New York, United States, 10591
Contact: Abraham J. Wu    212-639-7202      
Principal Investigator: Abraham J. Wu         
United States, North Carolina
CMC-LCI Radiation Therapy-Pineville Active, not recruiting
Charlotte, North Carolina, United States, 28210
Carolinas Medical Center Recruiting
Charlotte, North Carolina, United States, 28203
Contact: Jonathan C. Salo    704-355-2884      
Principal Investigator: Jonathan C. Salo         
Novant Health Presbyterian Medical Center Recruiting
Charlotte, North Carolina, United States, 28204
Contact: Justin P. Favaro    704-384-5369      
Principal Investigator: Justin P. Favaro         
Carolinas Medical Center - Northeast Recruiting
Concord, North Carolina, United States, 28025
Contact: Jonathan C. Salo    704-355-2884      
Principal Investigator: Jonathan C. Salo         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Matthews Radiation Oncology Center Terminated
Matthews, North Carolina, United States, 28105
Carolinas Medical Center-Union Recruiting
Monroe, North Carolina, United States, 28112
Contact: Jonathan C. Salo    704-355-2884      
Principal Investigator: Jonathan C. Salo         
Rex Cancer Center Recruiting
Raleigh, North Carolina, United States, 27607
Contact: Oludamilola A. Olajide    919-784-7209      
Principal Investigator: Oludamilola A. Olajide         
United States, North Dakota
Trinity Cancer Care Center Recruiting
Minot, North Dakota, United States, 58701
Contact: Kevin B. Collins    800-862-0005      
Principal Investigator: Kevin B. Collins         
United States, Ohio
Akron General Medical Center Withdrawn
Akron, Ohio, United States, 44307
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Geaugra Hospital Active, not recruiting
Chardon, Ohio, United States, 44024
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Kevin P. Redmond    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook    216-778-8526    kbauchens@metrohealth.org   
Principal Investigator: Bruce J. Averbook         
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Evan J. Wuthrick    866-627-7616    osu@emergingmed.com   
Principal Investigator: Evan J. Wuthrick         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Mercy Cancer Center-Elyria Recruiting
Elyria, Ohio, United States, 44035
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    317-783-8918      
Principal Investigator: Howard M. Gross         
Summa Health Center at Lake Medina Recruiting
Medina, Ohio, United States, 44256
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
Southwest General Health Center Ireland Cancer Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
UHHS-Chagrin Highlands Medical Center Recruiting
Orange Village, Ohio, United States, 44122
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
Saint Charles Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Robinson Radiation Oncology Withdrawn
Ravenna, Ohio, United States, 44266
Cancer Care Center, Incorporated Terminated
Salem, Ohio, United States, 44460
North Coast Cancer Care Active, not recruiting
Sandusky, Ohio, United States, 44870
Flower Hospital Recruiting
Sylvania, Ohio, United States, 43560
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Mercy Saint Anne Hospital Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
University of Toledo Recruiting
Toledo, Ohio, United States, 43614
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
University Pointe Recruiting
West Chester, Ohio, United States, 45069
Contact: Kevin P. Redmond    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
UHHS-Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Jennifer A. Dorth    800-641-2422      
Principal Investigator: Jennifer A. Dorth         
Cancer Treatment Center Terminated
Wooster, Ohio, United States, 44691
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Terence S. Herman    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Terence S. Herman         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Salem Hospital Recruiting
Salem, Oregon, United States, 97301
Contact: John Strother    503-561-2618      
Principal Investigator: John Strother         
United States, Pennsylvania
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Thomas J. Gergel    570-271-5251      
Principal Investigator: Thomas J. Gergel         
Delaware County Memorial Hospital Recruiting
Drexel Hill, Pennsylvania, United States, 19026
Contact: Rachelle M. Lanciano    610-284-8237    jolene.garney@crozer.org   
Principal Investigator: Rachelle M. Lanciano         
Northeast Radiation Oncology Center Recruiting
Dunmore, Pennsylvania, United States, 18512
Contact: Voichita Bar Ad    215-955-6084      
Principal Investigator: Voichita Bar Ad         
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111
Contact: Joshua E. Meyer    215-728-4790      
Principal Investigator: Joshua E. Meyer         
American College of Radiology Imaging Network Recruiting
Philadelphia, Pennsylvania, United States, 19103
Contact: Howard Safran       hsafran@lifespan.org   
Principal Investigator: Howard Safran         
Aria Health-Torresdale Campus Recruiting
Philadelphia, Pennsylvania, United States, 19114
Contact: Voichita Bar Ad    215-955-6084      
Principal Investigator: Voichita Bar Ad         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Dwight E. Heron    412-647-8073      
Principal Investigator: Dwight E. Heron         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Albert Yuen    610-988-9323      
Principal Investigator: Albert Yuen         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Thomas J. Gergel    570-271-5251      
Principal Investigator: Thomas J. Gergel         
Lankenau Hospital Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
United States, Rhode Island
Radiation Oncology Associates Incorporated Recruiting
Providence, Rhode Island, United States, 02904
Contact: Howard Safran    401-793-2224      
Principal Investigator: Howard Safran         
Rhode Island Hospital Recruiting
Providence, Rhode Island, United States, 02903
Contact: Howard Safran    401-793-2224      
Principal Investigator: Howard Safran         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Steve H. Chin    843-792-9321      
Principal Investigator: Steve H. Chin         
Greenville Health System Cancer Institute-Andrews Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute/Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
United States, Tennessee
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Anuradha B. Chakravarthy    800-811-8480      
Principal Investigator: Anuradha B. Chakravarthy         
United States, Texas
University of Texas Southwestern Medical Center Withdrawn
Dallas, Texas, United States, 75390
University of Texas Medical Branch at Galveston Recruiting
Galveston, Texas, United States, 77555-0565
Contact: Todd A. Swanson    409-772-1950    clinical.research@utmb.edu   
Principal Investigator: Todd A. Swanson         
Methodist Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Alexandria T. Phan    713-790-2700      
Principal Investigator: Alexandria T. Phan         
UTMB Cancer Center at Victory Lakes Recruiting
League City, Texas, United States, 77573
Contact: Todd A. Swanson    409-772-1950    clinical.research@utmb.edu   
Principal Investigator: Todd A. Swanson         
Covenant Medical Center-Lakeside Recruiting
Lubbock, Texas, United States, 79410
Contact: Paul J. Anderson    806-725-8000    jaccresearch@covhs.org   
Principal Investigator: Paul J. Anderson         
United States, Utah
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84157
Contact: R. J. Lee    801-507-3950      
Principal Investigator: R. J. Lee         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: R. J. Lee    801-507-3950      
Principal Investigator: R. J. Lee         
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: R. J. Lee    801-507-3950      
Principal Investigator: R. J. Lee         
United States, Virginia
Danville Regional Medical Center Active, not recruiting
Danville, Virginia, United States, 24541
United States, Washington
PeaceHealth Saint Joseph Medical Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Michael A. Taylor    360-788-8223    cpatz@peacehealth.org   
Principal Investigator: Michael A. Taylor         
Skagit Valley Hospital Recruiting
Mount Vernon, Washington, United States, 98274
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
Swedish Medical Center-First Hill Recruiting
Seattle, Washington, United States, 98122-4307
Contact: Gary E. Goodman    206-386-2323    patra.grevstad@swedish.org   
Principal Investigator: Gary E. Goodman         
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
Northwest CCOP Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Compass Oncology Vancouver Active, not recruiting
Vancouver, Washington, United States, 98684
United States, West Virginia
West Virginia University Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer    304-344-3457      
Principal Investigator: Steven J. Jubelirer         
Wheeling Hospital Recruiting
Wheeling, West Virginia, United States, 26003
Contact: Jondavid Pollock    304-243-6442      
Principal Investigator: Jondavid Pollock         
United States, Wisconsin
Sacred Heart Hospital Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311-6519
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: James L. Leenstra    920-433-8889      
Principal Investigator: James L. Leenstra         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: James L. Leenstra    920-433-8889      
Principal Investigator: James L. Leenstra         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Collin D. Driscoll    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Collin D. Driscoll         
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: James L. Leenstra    920-433-8889      
Principal Investigator: James L. Leenstra         
Vince Lombardi Cancer Clinic-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Saint Joseph's Hospital Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Candice A. Johnstone    414-805-4380    cancerhelp@dartmouth.edu   
Principal Investigator: Candice A. Johnstone         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Clement J. Zablocki VA Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53295
Contact: Elizabeth M. Gore    888-469-6614      
Principal Investigator: Elizabeth M. Gore         
Marshfield Clinic-Minocqua Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Marshfield Clinic-Rice Lake Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Door County Cancer Center Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: James L. Leenstra    920-433-8889      
Principal Investigator: James L. Leenstra         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Rezwan Islam    715-393-1400      
Principal Investigator: Rezwan Islam         
Sponsors and Collaborators
Investigators
Principal Investigator: Howard Safran Radiation Therapy Oncology Group
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01196390     History of Changes
Other Study ID Numbers: NCI-2011-02601, NCI-2011-02601, CDR0000683717, RTOG 1010, RTOG-1010, U10CA021661
Study First Received: September 4, 2010
Last Updated: June 23, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Adenocarcinoma
Esophageal Neoplasms
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Head and Neck Neoplasms
Digestive System Diseases
Esophageal Diseases
Gastrointestinal Diseases
Trastuzumab
Carboplatin
Paclitaxel
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents, Phytogenic

ClinicalTrials.gov processed this record on July 23, 2014