Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01169337
First received: July 23, 2010
Last updated: July 18, 2014
Last verified: June 2014
  Purpose

This phase II/III trial studies how well lenalidomide works and compares it to observation in treating patients with asymptomatic high-risk smoldering multiple myeloma. Biological therapies such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Sometimes the cancer may not need treatment until it progresses. In this case, observation may be sufficient.


Condition Intervention Phase
Light Chain Deposition Disease
Smoldering Multiple Myeloma
Drug: lenalidomide
Other: clinical observation
Other: laboratory biomarker analysis
Other: quality-of-life assessment
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase III Trial of Lenalidomide Versus Observation Alone in Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Incidence of grade 3 or higher toxicities based on Cancer Therapy Evaluation Program-Adverse Event Reporting System expedited reporting (Phase II) [ Time Frame: Up to 6 months ] [ Designated as safety issue: Yes ]
  • PFS (Phase III) [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    PFS in each of the arms will be estimated using the method of Kaplan and Meier. PFS between the two arms will be compared using a stratified log-rank test. Cox proportional hazards model will be used to assess PFS outcome in multiple regression analyses of established prognostic factors.


Secondary Outcome Measures:
  • Response rate (complete and partial response) [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Calculated with a 95% confidence interval.

  • Duration of response [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Estimated using the Kaplan-Meier method.

  • Incidence of adverse events graded according to National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [ Time Frame: Up to 10 years ] [ Designated as safety issue: Yes ]
    Adverse events will be monitored on all patients and summarized by arm. The difference in rates of all grade 3 or higher toxicities will be evaluated for all randomized patients using the Fisher's Exact test.

  • Overall survival (OS) [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Estimated using the method of Kaplan and Meier. OS between the two arms will be compared using stratified log-rank test. Cox proportional hazards model will be used to estimate the hazard rate between arms.


Other Outcome Measures:
  • Mean change of the FACT-FWB+PWB score [ Time Frame: Baseline to up to 24 months ] [ Designated as safety issue: No ]
    A two-sided t-test will be used.

  • Change in FACT-FWB+PWB mean scores between patients that experience disease progression (PD) and patients who do not experience PD [ Time Frame: Baseline to up to 48 months ] [ Designated as safety issue: No ]
    Assessed using mixed effects model.

  • Sensitivity for patients that did experience PD during the interval with respect to change in QOL in QOL status since last QOL assessment [ Time Frame: Up to 48 months ] [ Designated as safety issue: No ]
  • Reliability of PACT-FWB+PWB [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Descriptive statistics will be provided and Chronbach's alpha will be calculated to assess reliability.

  • Reliability of MMS [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Descriptive statistics will be provided and Chronbach's alpha will be calculated to assess reliability.

  • Differences in the MMS between the two arms [ Time Frame: At 24 months ] [ Designated as safety issue: No ]
  • Validity of FACT-PWB+FWB [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Patients will be segmented into clinical groups such as ECOG performance status 0-1 vs 2 that are expected to have significantly different scores and these relationships will be analyzed with 1-way multivariate analysis of variance (MANOVA). When MANOVA is significant then a univariate analysis of variance is done on each dependent variable.

  • Validity of MMS [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Patients will be segmented into clinical groups such as ECOG performance status 0-1 vs 2 that are expected to have significantly different scores and these relationships will be analyzed with 1-way MANOVA. When MANOVA is significant then a univariate analysis of variance is done on each dependent variable.

  • Change in gene expression profiling [ Time Frame: Baseline to up to 10 years ] [ Designated as safety issue: No ]
    Exploratory analyses will be performed to examine the underlying distributions using box plots, density plots, scatter plots, etc. Differential expression analysis of the two groups (baseline vs. off-study) will be performed.

  • Change in immune expression [ Time Frame: Baseline to up to 10 years ] [ Designated as safety issue: No ]
    Changes in immune expression will be evaluated only by descriptive statistics for hypothesis generation.

  • Presence of focal lesions on baseline MRI [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The data about the presence of focal lesions on baseline MRI studies will be analyzed and correlated with clinical outcome. The difference in response rates will be analyzed using the Fisher's exact test assuming a target overall response rate of 25% and 5% level of significance.

  • Prevalence of cytogenetic abnormalities [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    There will be 80% power with the logrank test to detect a hazard ratio comparing high-risk vs. standard-risk cytogenetic groups.


Estimated Enrollment: 380
Study Start Date: October 2010
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A (lenalidomide)
Patients receive lenalidomide PO QD on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug: lenalidomide
Given PO
Other Names:
  • CC-5013
  • IMiD-1
  • Revlimid
Other: laboratory biomarker analysis
Correlative studies
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Active Comparator: Arm B (observation)
Patients undergo observation until progression to symptomatic myeloma.
Other: clinical observation
Undergo observation
Other Name: observation
Other: laboratory biomarker analysis
Correlative studies
Other: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must be diagnosed with asymptomatic high-risk smoldering multiple myeloma (SMM) within the past 60 months, as confirmed by both of the following:

    • Bone marrow plasmacytosis with >= 10% plasma cells or sheets of plasma cells at any time before initiating study treatment, including a marrow which must be obtained by bone marrow aspiration and/or biopsy within 4 weeks prior to randomization
    • Abnormal serum free light chain ratio (< 0.26 or > 1.65) by serum free light chain (FLC) assay; FLC assay must be performed within 28 days of randomization
  • Patients must have measurable levels of monoclonal protein (M-protein): >= 1g/dL on serum protein electrophoresis or >= 200 mg of monoclonal protein on a 24 hour urine protein electrophoresis which must be obtained within 4 weeks prior to randomization
  • Patients must have no lytic lesions on skeletal surveys and no hypercalcemia (i.e., >= 11 mg/dL)
  • Hemoglobin >= 11 g/dL
  • Platelet count >= 100,000/mm^3
  • Absolute neutrophil count (ANC) >= 1,500/mm^3
  • Calculated creatinine clearance >= 30 mL/min
  • Bilirubin =< 1.5 mg/dL
  • Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and serum glutamic oxaloacetic transaminase (SGPT) (aspartate aminotransferase [AST]) =< 2.5 times upper limit of normal
  • No prior or concurrent systemic or radiation therapy for the treatment of myeloma
  • Concurrent use of bisphosphonates is not permitted; however, prior bisphosphonates or once-a-year intravenous bisphosphonate given for the treatment of osteoporosis is permitted
  • Prior or concurrent use of erythropoietin is disallowed
  • Prior glucocorticosteroid therapy for the treatment of multiple myeloma is not permitted
  • Prior systemic glucocorticosteroid use for the treatment of non-malignant disorders is permitted; concurrent use after registration on the study should be restricted to the equivalent of prednisone 10 mg per day
  • Prior or concurrent topical or localized glucocorticosteroid therapy to treat non-malignant comorbid disorders is permitted
  • Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last 6 months
  • Patients must not have uncontrolled intercurrent illness including uncontrolled hypertension, symptomatic congestive heart failure, unstable angina, uncontrolled cardiac arrhythmia, uncontrolled psychiatric illness or social situation that would limit compliance with the study, or a prior history of Stevens Johnson Syndrome
  • Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2
  • Patients must not have baseline bone lesions or plasmacytomas
  • Patients with monoclonal gammopathy of undetermined significance are not eligible
  • Patients must not have grade 2 or higher peripheral neuropathy
  • Patients must not have active, uncontrolled infection
  • Patients may have a history of current or previous deep vein thrombosis or pulmonary embolism but are required to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation
  • Patients should not have New York Heart Association classification III or IV heart failure
  • Patients with a history of prior malignancy are eligible provided they were treated with curative intent and have been free of disease for the time period considered appropriate for cure of the specific cancer; for most diseases this time frame is 5 years
  • Patients should not be felt to have an immediate need for chemotherapy
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days prior to and again within 24 hours of starting cycle 1 of lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy
  • Human immunodeficiency virus (HIV) infection is not excluded; HIV+ patients must meet the following criteria:

    • Cluster of differentiation (CD)4 cell count >= 350/mm^3
    • No history of acquired immune deficiency syndrome (AIDS)-related illness
    • Not currently prescribed zidovudine or stavudine
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01169337

  Hide Study Locations
Locations
United States, Arizona
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: John A. Lust    507-538-7623      
Principal Investigator: John A. Lust         
United States, California
Palo Alto Medical Foundation-Camino Division Withdrawn
Mountain View, California, United States, 94040
University of California Medical Center At Irvine-Orange Campus Recruiting
Orange, California, United States, 92868
Contact: Edward L. Nelson    877-827-8839    ucstudy@uci.edu   
Principal Investigator: Edward L. Nelson         
Palo Alto Medical Foundation Heath Care Recruiting
Palo Alto, California, United States, 94301
Contact: David S. Leibowitz    650-853-5757    hilld@pamf.org   
Principal Investigator: David S. Leibowitz         
Sutter Pacific Medical Foundation Recruiting
Santa Rosa, California, United States, 95403
Contact: Ari D. Baron    415-600-1182    SchmidtJ@cpmcri.org   
Principal Investigator: Ari D. Baron         
Palo Atlo Medical Foundation-Sunnyvale Recruiting
Sunnyvale, California, United States, 94806
Contact: Peter P. Yu    408-730-2800      
Principal Investigator: Peter P. Yu         
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
University of Colorado Cancer Center - Anschutz Cancer Pavilion Withdrawn
Aurora, Colorado, United States, 80045
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Cynthia K. Cathcart    888-785-6789      
Principal Investigator: Cynthia K. Cathcart         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary's Hospital and Regional Medical Center Withdrawn
Grand Junction, Colorado, United States, 81502
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Breast Cancer Care Consultants Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Suburban Medical Center Terminated
Thornton, Colorado, United States, 80229
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Danbury Hospital Recruiting
Danbury, Connecticut, United States, 06810
Contact: Marc G. Rappaport    203-739-8074      
Principal Investigator: Marc G. Rappaport         
Saint Francis Hospital and Medical Center Active, not recruiting
Hartford, Connecticut, United States, 06105
Manchester Memorial Hospital Recruiting
Manchester, Connecticut, United States, 06040
Contact: Michael A. Reale    860-533-4000      
Principal Investigator: Michael A. Reale         
Middlesex Hospital Active, not recruiting
Middletown, Connecticut, United States, 06457
The Hospital of Central Connecticut Recruiting
New Britain, Connecticut, United States, 06050
Contact: Brian J. Byrne    860-224-5660      
Principal Investigator: Brian J. Byrne         
Eastern Connecticut Hematology and Oncology Associates Recruiting
Norwich, Connecticut, United States, 06360
Contact: Dennis E. Slater    860-886-8362      
Principal Investigator: Dennis E. Slater         
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, Florida
Holy Cross Hospital Active, not recruiting
Fort Lauderdale, Florida, United States, 33308
Memorial Healthcare System - Joe DiMaggio Children's Hospital Recruiting
Hollywood, Florida, United States, 33021
Contact: Neil Nagovski    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Neil Nagovski         
Edna Williams Cancer Center at the Baptist Cancer Institute Recruiting
Jacksonville, Florida, United States, 32207
Contact: Troy H. Guthrie    904-202-7051      
Principal Investigator: Troy H. Guthrie         
Jupiter Medical Center Recruiting
Jupiter, Florida, United States, 33458
Contact: Michael A. Schwartz    305-674-2625    info@msccop.com   
Principal Investigator: Michael A. Schwartz         
Mount Sinai Medical Center CCOP Recruiting
Miami Beach, Florida, United States, 33140
Contact: Michael A. Schwartz    305-674-2625    info@msccop.com   
Principal Investigator: Michael A. Schwartz         
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Lee M. Zehngebot    407-303-5623      
Principal Investigator: Lee M. Zehngebot         
United States, Georgia
Phoebe Putney Memorial Hospital Recruiting
Albany, Georgia, United States, 31701
Contact: Jose M. Tongol    229-312-2251      
Principal Investigator: Jose M. Tongol         
Northside Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Thomas E. Seay    404-303-3355      
Principal Investigator: Thomas E. Seay         
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Sagar Lonial    404-778-1868      
Principal Investigator: Sagar Lonial         
Georgia Regents University Recruiting
Augusta, Georgia, United States, 30912
Contact: Sharad A. Ghamande    706-721-1663    cancer@georgiahealth.edu   
Principal Investigator: Sharad A. Ghamande         
Dekalb Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Jayanthi Srinivasiah    404-501-3279      
Principal Investigator: Jayanthi Srinivasiah         
Atlanta VA Medical Center Active, not recruiting
Decatur, Georgia, United States, 30033
Medical Center of Central Georgia Recruiting
Macon, Georgia, United States, 31208
Contact: Frederick M. Schnell    404-501-3279      
Principal Investigator: Frederick M. Schnell         
Saint Joseph's-Candler Health System Recruiting
Savannah, Georgia, United States, 31405
Contact: Mark A. Taylor    912-350-8568      
Principal Investigator: Mark A. Taylor         
United States, Idaho
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Saint Joseph Medical Center Active, not recruiting
Bloomington, Illinois, United States, 61701
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Graham Hospital Association Terminated
Canton, Illinois, United States, 61520
Memorial Hospital Terminated
Carthage, Illinois, United States, 62321
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Advocate Illinois Masonic Medical Center Recruiting
Chicago, Illinois, United States, 60657
Contact: Denise A. Levitan    336-713-6771      
Principal Investigator: Denise A. Levitan         
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Pritesh Patel    312-355-3046      
Principal Investigator: Pritesh Patel         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Eureka Hospital Active, not recruiting
Eureka, Illinois, United States, 61530
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Mason District Hospital Terminated
Havana, Illinois, United States, 62644
Illinois CancerCare-Havana Terminated
Havana, Illinois, United States, 62644
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Mcdonough District Hospital Terminated
Macomb, Illinois, United States, 61455
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Monmouth Terminated
Monmouth, Illinois, United States, 61462
Holy Family Medical Center Terminated
Monmouth, Illinois, United States, 61462
Community Cancer Center Foundation Active, not recruiting
Normal, Illinois, United States, 61761
Bromenn Regional Medical Center Terminated
Normal, Illinois, United States, 61761
Illinois CancerCare-Community Cancer Center Terminated
Normal, Illinois, United States, 61761
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Ottawa Regional Hospital and Healthcare Center Active, not recruiting
Ottawa, Illinois, United States, 61350
Pekin Cancer Treatment Center Active, not recruiting
Pekin, Illinois, United States, 61554
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Active, not recruiting
Peoria, Illinois, United States, 61615
Methodist Medical Center of Illinois Active, not recruiting
Peoria, Illinois, United States, 61603
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Proctor Hospital Terminated
Peoria, Illinois, United States, 61614
OSF Saint Francis Medical Center Active, not recruiting
Peoria, Illinois, United States, 61637
Illinois Valley Hospital Terminated
Peru, Illinois, United States, 61354
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Perry Memorial Hospital Terminated
Princeton, Illinois, United States, 61356
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Recruiting
Rockford, Illinois, United States, 61107
Contact: Harvey E. Einhorn    779-696-9400    cancercare@swedishamerican.org   
Principal Investigator: Harvey E. Einhorn         
Illinois CancerCare-Spring Valley Terminated
Spring Valley, Illinois, United States, 61362
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: James R. Egner    800-446-5532      
Principal Investigator: James R. Egner         
United States, Indiana
Saint Francis Hospital and Health Centers Recruiting
Beech Grove, Indiana, United States, 46107
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
IU Health Arnett Recruiting
Lafayette, Indiana, United States, 47904
Contact: Thomas I. Jones    800-899-8448ext7431    sstidham@clarianarnett.com   
Principal Investigator: Thomas I. Jones         
Reid Hospital and Health Care Services Recruiting
Richmond, Indiana, United States, 47374
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Hematology Oncology Associates-Quad Cities Active, not recruiting
Bettendorf, Iowa, United States, 52722
Genesis Medical Center - East Campus Active, not recruiting
Davenport, Iowa, United States, 52803
Mercy Medical Center-Sioux City Active, not recruiting
Sioux City, Iowa, United States, 51104
Saint Luke's Regional Medical Center Active, not recruiting
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
Kansas City Cancer Center-West Recruiting
Kansas City, Kansas, United States, 66112
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Salina Regional Health Center Recruiting
Salina, Kansas, United States, 67401
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Stormont-Vail Regional Health Center Recruiting
Topeka, Kansas, United States, 66604
Contact: David E. Einspahr    785-270-4963      
Principal Investigator: David E. Einspahr         
Wesley Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Charles V. Wendling    888-562-4763      
Principal Investigator: Charles V. Wendling         
Ochsner Health Center-Covington Withdrawn
Covington, Louisiana, United States, 70433
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Charles V. Wendling    888-562-4763      
Principal Investigator: Charles V. Wendling         
Ochsner Baptist Medical Center Active, not recruiting
New Orleans, Louisiana, United States, 70115
United States, Maryland
Walter Reed National Military Medical Center Recruiting
Bethesda, Maryland, United States, 20889-5600
Contact: David C. Van Echo    301-319-2100      
Principal Investigator: David C. Van Echo         
Union Hospital of Cecil County Terminated
Elkton MD, Maryland, United States, 21921
United States, Massachusetts
Caritas Saint Elizabeth's Medical Center Withdrawn
Brighton, Massachusetts, United States, 02135-2997
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Doreen B. Brettler    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Doreen B. Brettler         
United States, Michigan
Saint Joseph Mercy Hospital Active, not recruiting
Ann Arbor, Michigan, United States, 48106-0995
Michigan Cancer Research Consortium Community Clinical Oncology Program Active, not recruiting
Ann Arbor, Michigan, United States, 48106
Oakwood Hospital Active, not recruiting
Dearborn, Michigan, United States, 48124
Wayne State University/Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Divaya Bhutani    313-576-9363      
Principal Investigator: Divaya Bhutani         
Saint John Hospital and Medical Center Active, not recruiting
Detroit, Michigan, United States, 48236
Hurley Medical Center Active, not recruiting
Flint, Michigan, United States, 48502
Genesys Regional Medical Center-West Flint Campus Recruiting
Flint, Michigan, United States, 48532
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
Allegiance Health Active, not recruiting
Jackson, Michigan, United States, 49201
Bronson Methodist Hospital Active, not recruiting
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center Active, not recruiting
Kalamazoo, Michigan, United States, 49001
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Sparrow Hospital Active, not recruiting
Lansing, Michigan, United States, 48912
Saint Mary Mercy Hospital Active, not recruiting
Livonia, Michigan, United States, 48154
Saint Joseph Mercy Oakland Active, not recruiting
Pontiac, Michigan, United States, 48341-2985
Saint Joseph Mercy Port Huron Active, not recruiting
Port Huron, Michigan, United States, 48060
Saint Mary's of Michigan Active, not recruiting
Saginaw, Michigan, United States, 48601
Providence Hospital Recruiting
Southfield, Michigan, United States, 48075
Contact: Howard R. Terebelo    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Howard R. Terebelo         
Saint John Macomb-Oakland Hospital Active, not recruiting
Warren, Michigan, United States, 48093
United States, Minnesota
Essentia Health Saint Joseph's Medical Center Active, not recruiting
Brainerd, Minnesota, United States, 56401
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Essentia Health Saint Mary's Medical Center Active, not recruiting
Duluth, Minnesota, United States, 55805
Essentia Health Duluth Clinic CCOP Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel A. Nikcevich    888-203-7267      
Principal Investigator: Daniel A. Nikcevich         
Miller-Dwan Hospital Active, not recruiting
Duluth, Minnesota, United States, 55805
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Lake Region Healthcare Corporation-Cancer Care Recruiting
Fergus Falls, Minnesota, United States, 56537
Contact: Daniel A. Nikcevich    888-203-7267      
Principal Investigator: Daniel A. Nikcevich         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: John A. Lust    507-538-7623      
Principal Investigator: John A. Lust         
Metro-Minnesota CCOP Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Stephanie L. Elkins    601-815-6700      
Principal Investigator: Stephanie L. Elkins         
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Active, not recruiting
Bolivar, Missouri, United States, 65613
CoxHealth Cancer Center Active, not recruiting
Branson, Missouri, United States, 65616
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Southeast Cancer Center Active, not recruiting
Cape Girardeau, Missouri, United States, 63703
Capital Region Medical Center-Goldschmidt Cancer Center Active, not recruiting
Jefferson City, Missouri, United States, 65109
Kansas City Veterans Affairs Medical Center Active, not recruiting
Kansas City, Missouri, United States, 64128
Truman Medical Center Recruiting
Kansas City, Missouri, United States, 64108
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Kansas City Cancer Center - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Kansas City Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Comprehensive Cancer Care PC Terminated
Saint Louis, Missouri, United States, 63141
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Saint Louis Cancer and Breast Institute-South City Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Jay W. Carlson    800-821-7532    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Mercy Hospital Springfield Active, not recruiting
Springfield, Missouri, United States, 65804
CoxHealth South Hospital Active, not recruiting
Springfield, Missouri, United States, 65807
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Active, not recruiting
Springfield, Missouri, United States, 65804
United States, Montana
Saint Vincent Healthcare Active, not recruiting
Billings, Montana, United States, 59101
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Consortium CCOP Active, not recruiting
Billings, Montana, United States, 59101
Hematology-Oncology Centers of the Northern Rockies PC Terminated
Billings, Montana, United States, 59102
Bozeman Deaconess Cancer Center Withdrawn
Bozeman, Montana, United States, 59715
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Active, not recruiting
Butte, Montana, United States, 59701
Benefis Healthcare- Sletten Cancer Institute Active, not recruiting
Great Falls, Montana, United States, 59405
Great Falls Clinic Terminated
Great Falls, Montana, United States, 59405
Northern Montana Hospital Terminated
Havre, Montana, United States, 59501
Saint Peter's Community Hospital Active, not recruiting
Helena, Montana, United States, 59601
Glacier Oncology PLLC Terminated
Kalispell, Montana, United States, 59901
Kalispell Medical Oncology Terminated
Kalispell, Montana, United States, 59901
Kalispell Regional Medical Center Active, not recruiting
Kalispell, Montana, United States, 59901
Montana Cancer Specialists Active, not recruiting
Missoula, Montana, United States, 59802
Saint Patrick Hospital - Community Hospital Active, not recruiting
Missoula, Montana, United States, 59802
United States, Nebraska
Nebraska Cancer Research Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Alegent Health Immanuel Medical Center Active, not recruiting
Omaha, Nebraska, United States, 68122
Missouri Valley Cancer Consortium CCOP Active, not recruiting
Omaha, Nebraska, United States, 68106
Alegent Health Bergan Mercy Medical Center Active, not recruiting
Omaha, Nebraska, United States, 68124
Creighton University Medical Center Active, not recruiting
Omaha, Nebraska, United States, 68131
United States, Nevada
Nevada Cancer Research Foundation CCOP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
United States, New Jersey
Cooper Hospital University Medical Center Active, not recruiting
Camden, New Jersey, United States, 08103
Veterans Adminstration New Jersey Health Care System Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Basil S. Kasimis    800-475-2336    patricia.goyer@med.va.gov   
Principal Investigator: Basil S. Kasimis         
Newark Beth Israel Medical Center Recruiting
Newark, New Jersey, United States, 07112
Contact: Lori Schleicher    973-926-7230      
Principal Investigator: Lori Schleicher         
United States, New Mexico
Presbyterian Kaseman Hospital Recruiting
Albuquerque, New Mexico, United States, 87110
Contact: Dulcinea D. Quintana    505-272-6972      
Principal Investigator: Dulcinea D. Quintana         
University of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Dulcinea D. Quintana    505-272-6972      
Principal Investigator: Dulcinea D. Quintana         
United States, New York
Albert Einstein College of Medicine Recruiting
Bronx, New York, United States, 10461
Contact: Stefan K. Barta    215-728-4790    aecc@aecom.yu.edu   
Principal Investigator: Stefan K. Barta         
Montefiore Medical Center - Moses Campus Recruiting
Bronx, New York, United States, 10467-2490
Contact: Stefan K. Barta    215-728-4790    aecc@aecom.yu.edu   
Principal Investigator: Stefan K. Barta         
United States, North Carolina
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm    704-873-5661      
Principal Investigator: Ruby A. Grimm         
United States, North Dakota
Saint Alexius Medical Center Terminated
Bismarck, North Dakota, United States, 58501
Mid Dakota Clinic Terminated
Bismarck, North Dakota, United States, 58501
Bismarck Cancer Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: John T. Reynolds    701-323-5760    tfischer@mohs.org   
Principal Investigator: John T. Reynolds         
Sanford Bismarck Medical Center Withdrawn
Bismarck, North Dakota, United States, 58501
United States, Ohio
Mary Rutan Hospital Terminated
Bellefontaine, Ohio, United States, 43311
Adena Regional Medical Center Active, not recruiting
Chillicothe, Ohio, United States, 45601
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook    216-778-8526    kbauchens@metrohealth.org   
Principal Investigator: Bruce J. Averbook         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Erica L. Campagnaro    800-641-2422      
Principal Investigator: Erica L. Campagnaro         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Grant Medical Center Active, not recruiting
Columbus, Ohio, United States, 43215
Columbus Oncology and Hematology Associates Inc Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Doctors Hospital Active, not recruiting
Columbus, Ohio, United States, 43228
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Columbus CCOP Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Grandview Hospital Recruiting
Dayton, Ohio, United States, 45405
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Dayton CCOP Recruiting
Dayton, Ohio, United States, 45420
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Samaritan North Health Center Recruiting
Dayton, Ohio, United States, 45415
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Grady Memorial Hospital Active, not recruiting
Delaware, Ohio, United States, 43015
Blanchard Valley Hospital Recruiting
Findlay, Ohio, United States, 45840
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Atrium Medical Center-Middletown Regional Hospital Recruiting
Franklin, Ohio, United States, 45005-1066
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Wayne Hospital Recruiting
Greenville, Ohio, United States, 45331
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Fairfield Medical Center Active, not recruiting
Lancaster, Ohio, United States, 43130
Saint Rita's Medical Center Recruiting
Lima, Ohio, United States, 45801
Contact: Henry Gerad    419-226-9617      
Principal Investigator: Henry Gerad         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Knox Community Hospital Active, not recruiting
Mount Vernon, Ohio, United States, 43050
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Clinton Memorial Hospital Terminated
Wilmington, Ohio, United States, 45177
Greene Memorial Hospital Recruiting
Xenia, Ohio, United States, 45385
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Genesis HealthCare System Active, not recruiting
Zanesville, Ohio, United States, 43701
United States, Oklahoma
University of Oklahoma Health Sciences Center Withdrawn
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Clackamas Radiation Oncology Center Active, not recruiting
Clackamas, Oregon, United States, 97015
Providence Milwaukie Hospital Recruiting
Milwaukie, Oregon, United States, 97222
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Western Oncology Research Consortium Active, not recruiting
Portland, Oregon, United States, 97213
United States, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus Active, not recruiting
Bethlehem, Pennsylvania, United States, 18015
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
Pennsylvania Hospital Withdrawn
Philadelphia, Pennsylvania, United States, 19107
Fox Chase Cancer Center Active, not recruiting
Philadelphia, Pennsylvania, United States, 19111
Pottstown Memorial Medical Center Active, not recruiting
Pottstown, Pennsylvania, United States, 19464
Guthrie Medical Group PC-Robert Packer Hospital Recruiting
Sayre, Pennsylvania, United States, 18840
Contact: Philip A. Lowry    800-836-0388      
Principal Investigator: Philip A. Lowry         
Geisinger Medical Group Active, not recruiting
State College, Pennsylvania, United States, 16801
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Susquehanna Cancer Center Recruiting
Williamsport, Pennsylvania, United States, 17701
Contact: Warren L. Robinson    800-598-4282      
Principal Investigator: Warren L. Robinson         
Lankenau Hospital Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
United States, South Carolina
Roper Hospital Recruiting
Charleston, South Carolina, United States, 29401
Contact: James M. Orcutt    843-720-8386    elizabeth.strojny@roperstfrancis.com   
Principal Investigator: James M. Orcutt         
Greenville Health System Cancer Institute-Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute/Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Self Regional Healthcare Active, not recruiting
Greenwood, South Carolina, United States, 29646
Cancer Centers of the Carolinas-Greer Medical Oncology Withdrawn
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
United States, South Dakota
Conklin Regional Cancer Center Recruiting
Aberdeen, South Dakota, United States, 57401
Contact: Richard J. Conklin    605-622-5613      
Principal Investigator: Richard J. Conklin         
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Mark T. Schroeder    605-716-3982    research@rcrh.org   
Principal Investigator: Mark T. Schroeder         
Avera McKennan Hospital and University Health Center Terminated
Sioux Falls, South Dakota, United States, 57105
Avera Cancer Institute Withdrawn
Sioux Falls, South Dakota, United States, 57105
United States, Tennessee
Jackson-Madison County General Hospital Recruiting
Jackson, Tennessee, United States, 38301
Contact: Salomon Asmar    731-425-6865      
Principal Investigator: Salomon Asmar         
Wellmont Holston Valley Hospital and Medical Center Active, not recruiting
Kingsport, Tennessee, United States, 37660
University of Tennessee - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Wahid T. Hanna    865-544-9773      
Principal Investigator: Wahid T. Hanna         
United States, Texas
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Larry D. Anderson    214-648-7097      
Principal Investigator: Larry D. Anderson         
United States, Vermont
Rutland Regional Medical Center Recruiting
Rutland, Vermont, United States, 05701
Contact: Allan D. Eisemann    802-775-7111      
Principal Investigator: Allan D. Eisemann         
United States, Virginia
Danville Regional Medical Center Active, not recruiting
Danville, Virginia, United States, 24541
Southwest VA Regional Cancer Center Active, not recruiting
Norton, Virginia, United States, 24273
United States, Washington
Good Samaritan Community Hospital Recruiting
Puyallup, Washington, United States, 98372
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Multicare Health System Recruiting
Tacoma, Washington, United States, 98415
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
Northwest CCOP Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-2394      
Principal Investigator: Yoshio Inoue         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Compass Oncology Vancouver Active, not recruiting
Vancouver, Washington, United States, 98684
United States, West Virginia
West Virginia University Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer    304-344-3457      
Principal Investigator: Steven J. Jubelirer         
United States, Wisconsin
Aurora Cancer Care-Burlington Recruiting
Burlington, Wisconsin, United States, 53105
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic-Chippewa Center Recruiting
Chippewa Falls, Wisconsin, United States, 54729
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Marshfield Clinic Cancer Center at Sacred Heart Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Aurora Cancer Care-Southern Lakes Recruiting
Elkhorn, Wisconsin, United States, 53121
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Grafton Recruiting
Grafton, Wisconsin, United States, 53024
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311-6519
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Kenosha South Recruiting
Kenosha, Wisconsin, United States, 53142
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
Dean Hematology and Oncology Clinic Recruiting
Madison, Wisconsin, United States, 53717
Contact: Amit Sanyal    608-410-2700      
Principal Investigator: Amit Sanyal         
Vince Lombardi Cancer Clinic-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Aurora Advanced Healthcare Inc-Menomonee Falls Recruiting
Menomonee Falls, Wisconsin, United States, 53051
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Columbia Saint Mary's Hospital - Ozaukee Recruiting
Mequon, Wisconsin, United States, 53097
Contact: Charles H. Tiber    414-326-2675    clinicaltrials@columbia-stmarys.org   
Principal Investigator: Charles H. Tiber         
Aurora Cancer Care-Milwaukee Recruiting
Milwaukee, Wisconsin, United States, 53209
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Columbia Saint Mary's Water Tower Medical Commons Recruiting
Milwaukee, Wisconsin, United States, 53211
Contact: Charles H. Tiber    414-326-2675    clinicaltrials@columbia-stmarys.org   
Principal Investigator: Charles H. Tiber         
Aurora Sinai Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53233
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Milwaukee South Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic-Minocqua Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Racine Recruiting
Racine, Wisconsin, United States, 53406-5661
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic at James Beck Cancer Center Recruiting
Rhinelander, Wisconsin, United States, 54501
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Marshfield Clinic-Rice Lake Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic Cancer Care at Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Vince Lombardi Cancer Clinic Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora Cancer Care-Waukesha Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Waukesha Memorial Hospital - ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Aurora Cancer Care-Milwaukee West Recruiting
Wauwatosa, Wisconsin, United States, 53226
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Marshfield Clinic - Weston Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
Marshfield Clinic - Wisconsin Rapids Center Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Matthias Weiss    800-347-0673      
Principal Investigator: Matthias Weiss         
United States, Wyoming
Rocky Mountain Oncology Active, not recruiting
Casper, Wyoming, United States, 82609
Welch Cancer Center Active, not recruiting
Sheridan, Wyoming, United States, 82801
Ireland
Mater Misericordiae University Hospital Active, not recruiting
Dublin, Co Dublin, Ireland, 7
Mater Private Hospital Active, not recruiting
Dublin, Co Dublin, Ireland, 7
University College Hospital Galway Active, not recruiting
Galway, Co Galway, Ireland
Sponsors and Collaborators
Investigators
Principal Investigator: Sagar Lonial ECOG-ACRIN Cancer Research Group
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01169337     History of Changes
Other Study ID Numbers: NCI-2011-02057, NCI-2011-02057, ECOG-E3A06, CDR0000682012, E3A06, E3A06, U10CA180820, U10CA021115
Study First Received: July 23, 2010
Last Updated: July 18, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Neoplasms
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Paraproteinemias
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoproliferative Disorders
Immunoproliferative Disorders
Immune System Diseases
Lenalidomide
Thalidomide
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Leprostatic Agents
Anti-Bacterial Agents
Anti-Infective Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors

ClinicalTrials.gov processed this record on July 23, 2014