A Study of Pemetrexed & Carboplatin/Cisplatin or Gemcitabine & Carboplatin/Cisplatin With or Without IMC-1121B in Patients Previously Untreated With Recurrent or Advanced Non-small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

• Confirmed Non-small Cell Lung Cancer
• Stage IV disease at the time of study entry
• Measurable disease at the time of study entry
• Resolution to Grade ≤ 1 Adverse Events, of all clinically significant toxic effects of prior chemotherapy, surgery, radiotherapy, or hormonal therapy (except alopecia)
• Adequate hematologic function, hepatic function, renal function and coagulation function
• If sexually active, must be postmenopausal, surgically sterile, or using effective contraception; And agrees to use adequate contraception during the study period and for up to 6 months after the last dose of study medication
• Female patients of childbearing potential must have a negative serum pregnancy test

Exclusion Criteria:

• Has cirrhosis at a level of Child-Pugh B (or worse), or cirrhosis and a history of hepatic encephalopathy, or ascites resulting from cirrhosis and requiring ongoing treatment with diuretics and/or paracentesis
• Tumor wholly or partially contains small cell lung cancer
• Untreated central nervous system (CNS) metastases, eligible if they are clinically stable with regard to neurologic function, off all steroids after cranial irradiation at least 2 weeks prior or after surgical resection performed at least 4 weeks prior to randomization
• Concurrent active malignancy other than adequately treated basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix. A patient with previous history of malignancy other than NSCLC is eligible, provided that he/she has been free of disease for ≥ 3 years
• Received prior therapy with monoclonal antibodies, signal transduction inhibitors, or any therapies targeting the VEGF or VEGFR
• Receiving concurrent treatment with other anticancer therapy
• Has received previous chemotherapy for Stage IV NSCLC (patients who have received adjuvant chemotherapy are eligible if the last administration of the prior adjuvant regimen occurred at least 6 months prior to randomization)
• Has radiologically documented evidence of major blood vessel invasion or encasement by cancer
• Has undergone chest irradiation within 12 weeks prior to randomization (except palliative irradiation of bone lesions)
• Ongoing or active infection
• History of significant neurological or psychiatric disorders
• Experienced clinically relevant coronary artery disease, myocardial infarction within 6 months prior to randomization, uncontrolled congestive heart failure, or symptomatic poorly controlled arrhythmia
• Poorly-controlled hypertension
• Experienced any serious 3-4 gastrointestinal bleeding within 3 months prior to study entry
• Receiving chronic daily treatment with aspirin (> 325 mg/day) or other known inhibitors of platelet function
• Serious nonhealing wound, ulcer, or bone fracture within 28 days prior to randomization
• Major surgery within 28 days prior the first dose of study medication, or subcutaneous venous access device placement within 7 days prior to randomization
• Elective or a planned major surgery
• Pregnant or lactating
• Any other serious uncontrolled medical disorders or psychological conditions
• Allergy / history of hypersensitivity reaction to any of the treatment components
• History of drug abuse