Special Investigation in Patients With Psoriasis Vulgaris and Psoriatic Arthritis (All Patients Investigation)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
AbbVie ( AbbVie (prior sponsor, Abbott) )
ClinicalTrials.gov Identifier:
NCT01155570
First received: June 30, 2010
Last updated: September 30, 2013
Last verified: September 2013
  Purpose

The survey will be conducted with regard to the following aspects of treatment with Humira (adalimumab) in patients with psoriasis vulgaris and psoriatic arthritis receiving this drug:

  • unknown adverse drug reactions, especially clinically significant adverse reactions
  • incidence and conditions of occurrence of adverse reactions in the clinical setting
  • factors that may affect the safety and effectiveness of Humira.

Condition
Psoriasis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Special Investigation (All Cases Investigation in Patients With Psoriasis Vulgaris and Psoriatic Arthritis)

Resource links provided by NLM:


Further study details as provided by AbbVie:

Primary Outcome Measures:
  • Number of Participants With Adverse Events (AEs), Serious Adverse Events (SAEs), Adverse Drug Reactions (ADRs), Serious Adverse Drug Reactions (SADRs), Deaths, and Discontinuations Due to AEs [ Time Frame: From study registration through Week 24 ] [ Designated as safety issue: Yes ]
    This study was mandated by the Japanese government as an approval condition for Humira in Japan; therefore, definitions of adverse events and seriousness criteria were applicable as specified in the Japanese local standard operating procedures, based on local Japanese regulations. ADRs were defined as adverse events for which the causal relationship with Humira was other than "not related" (ie, "probable," "possible," or "unclear"). The count of participants with AEs presented in this table includes serious and nonserious AEs. The count of participants with discontinuations due to AEs includes those who discontinued due to an AE plus other reasons. Please see Safety section for further details regarding adverse events.

  • Physician's Global Assessment at Week 4 [ Time Frame: Week 4 ] [ Designated as safety issue: No ]

    The Physician's Global Assessment (PGA) is a 6-point scale used to measure the severity of disease at the time of the physician's evaluation of the participant. The degree of overall lesion severity was evaluated using the following categories:

    • 0 / Clear (plaque elevation=none, scaling=none, erythema=hyperpigmentation, pigmented macules, diffuse faint pink or red coloration);
    • 1 / Minimal (plaque elevation=possible but difficult to ascertain whether there is a slight elevation above normal skin, scaling=surface dryness with some white coloration, erythema=up to moderate);
    • 2 / Mild (plaque elevation=slight, scaling=fine, erythema=up to moderate);
    • 3 / Moderate (plaque elevation=moderate, scaling=coarser, erythema=moderate);
    • 4 / Severe (plaque elevation=marked, scaling=coarse, erythema=severe);
    • 5 / Very Severe (plaque elevation=very marked, scaling=very coarse, erythema=very severe).

  • Physician's Global Assessment At Week 8 [ Time Frame: Week 8 ] [ Designated as safety issue: No ]

    The Physician's Global Assessment (PGA) is a 6-point scale used to measure the severity of disease at the time of the physician's evaluation of the participant. The degree of overall lesion severity was evaluated using the following categories:

    • 0 / Clear (plaque elevation=none, scaling=none, erythema=hyperpigmentation, pigmented macules, diffuse faint pink or red coloration);
    • 1 / Minimal (plaque elevation=possible but difficult to ascertain whether there is a slight elevation above normal skin, scaling=surface dryness with some white coloration, erythema=up to moderate);
    • 2 / Mild (plaque elevation=slight, scaling=fine, erythema=up to moderate);
    • 3 / Moderate (plaque elevation=moderate, scaling=coarser, erythema=moderate);
    • 4 / Severe (plaque elevation=marked, scaling=coarse, erythema=severe);
    • 5 / Very Severe (plaque elevation=very marked, scaling=very coarse, erythema=very severe).

  • Physician's Global Assessment at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]

    The Physician's Global Assessment (PGA) is a 6-point scale used to measure the severity of disease at the time of the physician's evaluation of the participant. The degree of overall lesion severity was evaluated using the following categories:

    • 0 / Clear (plaque elevation=none, scaling=none, erythema=hyperpigmentation, pigmented macules, diffuse faint pink or red coloration);
    • 1 / Minimal (plaque elevation=possible but difficult to ascertain whether there is a slight elevation above normal skin, scaling=surface dryness with some white coloration, erythema=up to moderate);
    • 2 / Mild (plaque elevation=slight, scaling=fine, erythema=up to moderate);
    • 3 / Moderate (plaque elevation=moderate, scaling=coarser, erythema=moderate);
    • 4 / Severe (plaque elevation=marked, scaling=coarse, erythema=severe);
    • 5 / Very Severe (plaque elevation=very marked, scaling=very coarse, erythema=very severe).

  • Physician's Global Assessment at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]

    The Physician's Global Assessment (PGA) is a 6-point scale used to measure the severity of disease at the time of the physician's evaluation of the participant. The degree of overall lesion severity was evaluated using the following categories:

    • 0 / Clear (plaque elevation=none, scaling=none, erythema=hyperpigmentation, pigmented macules, diffuse faint pink or red coloration);
    • 1 / Minimal (plaque elevation=possible but difficult to ascertain whether there is a slight elevation above normal skin, scaling=surface dryness with some white coloration, erythema=up to moderate);
    • 2 / Mild (plaque elevation=slight, scaling=fine, erythema=up to moderate);
    • 3 / Moderate (plaque elevation=moderate, scaling=coarser, erythema=moderate);
    • 4 / Severe (plaque elevation=marked, scaling=coarse, erythema=severe);
    • 5 / Very Severe (plaque elevation=very marked, scaling=very coarse, erythema=very severe).

  • Psoriasis Area and Severity Index (PASI) at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]
    PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination. The score ranges from 0 (no psoriasis) to 72 (very severe psoriasis).

  • Psoriasis Area and Severity Index (PASI) at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]
    PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination. The score ranges from 0 (no psoriasis) to 72 (very severe psoriasis).

  • Percentage of Participants With Psoriasis Area and Severity Index 75 (PASI75) Response at Week 16 [ Time Frame: Baseline and Week 16 ] [ Designated as safety issue: No ]
    PASI75 is defined as at least a 75% reduction in PASI (Psoriasis Area and Severity Index) score compared with the Baseline PASI score. PASI scores range from 0 (best) to 72 (worst), with the highest score representing complete erythroderma of the severest degree. The percent decrease in score is calculated as (Week 0 PASI score minus Week 16 PASI score) divided by Week 0 PASI score.

  • Percentage of Participants With Psoriasis Area and Severity Index 75 (PASI75) Response at Week 24 [ Time Frame: Baseline and Week 24 ] [ Designated as safety issue: No ]
    PASI75 is defined as at least a 75% reduction in PASI (Psoriasis Area and Severity Index) score compared with the Baseline PASI score. PASI scores range from 0 (best) to 72 (worst), with the highest score representing complete erythroderma of the severest degree. The percent decrease in score is calculated as (Week 0 PASI score minus Week 24 PASI score) divided by Week 0 PASI score.

  • Percentage of Participants With Psoriasis Area and Severity Index 90 (PASI90) Response at Week 16 [ Time Frame: Baseline and Week 16 ] [ Designated as safety issue: No ]
    PASI90 is defined as at least a 90% reduction in PASI (Psoriasis Area and Severity Index) score compared with the Baseline PASI score. PASI scores range from 0 (best) to 72 (worst), with the highest score representing complete erythroderma of the severest degree. The percent decrease in score is calculated as (Week 0 PASI score minus Week 16 PASI score) divided by Week 0 PASI score.

  • Percentage of Participants With Psoriasis Area and Severity Index 90 (PASI90) Response at Week 24 [ Time Frame: Baseline and Week 24 ] [ Designated as safety issue: No ]
    PASI90 is defined as at least a 90% reduction in PASI (Psoriasis Area and Severity Index) score compared with the Baseline PASI score. PASI scores range from 0 (best) to 72 (worst), with the highest score representing complete erythroderma of the severest degree. The percent decrease in score is calculated as (Week 0 PASI score minus Week 24 PASI score) divided by Week 0 PASI score.

  • Dermatology Life Quality Index at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]
    Dermatology Life Quality Index (DLQI) score is a participant-reported outcome consisting of a set of 10 questions regarding the degree to which the participant's skin has affected certain behaviors and quality of life over the last week. Responses to each are: very much (score of 3), a lot (score of 2), a little (score of 1), or not at all (score of 0). The DLQI score ranges from 0 (best) to 30 (worst); the higher the score, the more quality of life is impaired.

  • Dermatology Life Quality Index at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]
    Dermatology Life Quality Index (DLQI) score is a participant-reported outcome consisting of a set of 10 questions regarding the degree to which the participant's skin has affected certain behaviors and quality of life over the last week. Responses to each are: very much (score of 3), a lot (score of 2), a little (score of 1), or not at all (score of 0). The DLQI score ranges from 0 (best) to 30 (worst); the higher the score, the more quality of life is impaired.

  • Pain Visual Analog Scale (VAS) at Week 4 [ Time Frame: Week 4 ] [ Designated as safety issue: No ]
    Participants assessed their pain due to psoriatic arthritis in the past week, on a single-line Visual Analog Scale (VAS) from 0 (no pain) to 100 (pain as bad as it could be).

  • Pain Visual Analog Scale (VAS) at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]
    Participants assessed their pain due to psoriatic arthritis in the past week, on a single-line Visual Analog Scale (VAS) from 0 (no pain) to 100 (pain as bad as it could be).

  • Pain Visual Analog Scale (VAS) at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]
    Participants assessed their pain due to psoriatic arthritis in the past week, on a single-line Visual Analog Scale (VAS) from 0 (no pain) to 100 (pain as bad as it could be).

  • Disease Activity Score 28-4, Erythrocyte Sedimentation Rate (DAS28-4 [ESR]) at Week 4 [ Time Frame: Week 4 ] [ Designated as safety issue: No ]
    DAS28-4 (ESR) is calculated using the number of tender and swollen joints (out of 28 counted), erythrocyte sedimentation rate (ESR), and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.

  • Disease Activity Score 28-4, Erythrocyte Sedimentation Rate (DAS28-4 [ESR]) at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]
    DAS28-4 (ESR) is calculated using the number of tender and swollen joints (out of 28 counted), erythrocyte sedimentation rate (ESR), and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.

  • Disease Activity Score 28-4, Erythrocyte Sedimentation Rate (DAS28-4 [ESR]) at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]
    DAS28-4 (ESR) is calculated using the number of tender and swollen joints (out of 28 counted), erythrocyte sedimentation rate (ESR), and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.

  • Disease Activity Score 28-4, C-reactive Protein (DAS28-4 [CRP]) at Week 4 [ Time Frame: Week 4 ] [ Designated as safety issue: No ]
    DAS28-4 (CRP) is calculated using the number of tender and swollen joints (out of 28 counted), C-reactive protein (CRP) level, and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.

  • Disease Activity Score 28-4, C-reactive Protein (DAS28-4 [CRP]) at Week 16 [ Time Frame: Week 16 ] [ Designated as safety issue: No ]
    DAS28-4 (CRP) is calculated using the number of tender and swollen joints (out of 28 counted), C-reactive protein (CRP) level, and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.

  • Disease Activity Score 28-4, C-reactive Protein (DAS28-4 [CRP]) at Week 24 [ Time Frame: Week 24 ] [ Designated as safety issue: No ]
    DAS28-4 (CRP) is calculated using the number of tender and swollen joints (out of 28 counted), C-reactive protein (CRP) level, and the patient's global assessment of disease activity via the visual analog scale (VAS). The calculated range of DAS28-4 is 0 to 10. A score less than 2.6 indicates clinical remission, a score of 2.6 to 3.2 indicates low disease activity, a score of 3.2 to less than 5.1 indicates moderate disease activity, and a score of 5.1 or greater indicates high disease activity.


Secondary Outcome Measures:
  • Physician's Overall Response Rating At Week 24 [ Time Frame: Baseline and Week 24 ] [ Designated as safety issue: No ]
    Overall response rating, according to investigator's subjective clinical opinion. The level of overall improvement rating was categorized as "markedly improved," "improved," "not changed," or "not assessable," comparing clinical conditions at Week 24 or at discontinuation with Baseline conditions.


Enrollment: 752
Study Start Date: February 2010
Study Completion Date: July 2012
Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Humira
Humira 40 mg (marketed product) every other week (eow) for subcutaneous injection after initial dosage of 80 mg.

Detailed Description:

This study was non-interventional, open-labeled, all-cases, central registration method, post marketing observational study in which Humira was prescribed for patients with psoriasis vulgaris and/or psoriatic arthritis in routine medical practice.

When investigators prescribed Humira to an eligible patient who provided informed consent, they filled out a registration form and send it to the registration center via postal mail. At the end of the 24-week observation period, an investigator filled out a case report form for each patient to describe the findings during the study period, and provided the completed form to medical representatives. Even if Humira treatment was for any reason discontinued, the investigators followed each such participant for 24 weeks after the first administration of Humira, and filled out a case report form for the participant at the end of the 24-week period.

Some participants entered this study from study NCT00647400 (M04-702), a Phase III extension study of Humira (adalimumab) in Japan.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All patients who receive Humira for the treatment of psoriasis vulgaris or psoriatic arthritis

Criteria

Inclusion Criteria:

All patients who receive Humira for the treatment of psoriasis vulgaris or psoriatic arthritis not responding to conventional treatment will be evaluated. Eligible patients should be

  • those not responding to at least one type of conventional systemic treatment (including ultraviolet therapy) who have skin lesions involving 10% of body surface area or
  • patients with intractable eruptions of joint signs/symptoms.

Exclusion Criteria:

Contraindications according to the Package Insert include patients who have any of the following:

  • serious infections
  • tuberculosis
  • a history of hypersensitivity to any ingredient of Humira
  • demyelinating disease or a history of demyelinating disease
  • congestive cardiac failure.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01155570

  Hide Study Locations
Locations
Japan
Site Reference ID/Investigator# 56252
Aichi, Japan
Site Reference ID/Investigator# 56254
Aichi, Japan
Site Reference ID/Investigator# 56340
Aichi, Japan
Site Reference ID/Investigator# 56131
Aichi, Japan
Site Reference ID/Investigator# 41769
Aichi, Japan
Site Reference ID/Investigator# 60016
Aichi, Japan
Site Reference ID/Investigator# 67150
Aichi, Japan
Site Reference ID/Investigator# 41810
Aichi, Japan
Site Reference ID/Investigator# 56251
Aichi, Japan
Site Reference ID/Investigator# 41606
Aichi, Japan
Site Reference ID/Investigator# 68627
Aichi, Japan
Site Reference ID/Investigator# 41327
Aizuwakamatsu, Japan
Site Reference ID/Investigator# 41820
Akita, Japan
Site Reference ID/Investigator# 41823
Akita, Japan
Site Reference ID/Investigator# 41684
Amagasaki, Japan
Site Reference ID/Investigator# 41851
Amagasaki, Japan
Site Reference ID/Investigator# 41305
Anjo, Japan
Site Reference ID/Investigator# 64811
Aomori, Japan
Site Reference ID/Investigator# 41822
Aomori, Japan
Site Reference ID/Investigator# 60012
Aomori, Japan
Site Reference ID/Investigator# 41800
Asahikawa, Japan
Site Reference ID/Investigator# 80887
Ashikaga, Japan
Site Reference ID/Investigator# 80879
Ayabe, Japan
Site Reference ID/Investigator# 41207
Bunkyo-ku, Tokyo, Japan
Site Reference ID/Investigator# 56224
Chiba, Japan
Site Reference ID/Investigator# 59995
Chiba, Japan
Site Reference ID/Investigator# 41260
Chiba, Japan
Site Reference ID/Investigator# 41247
Chiba, Japan
Site Reference ID/Investigator# 41263
Chiba, Japan
Site Reference ID/Investigator# 41927
Chiba, Japan
Site Reference ID/Investigator# 41258
Chiba, Japan
Site Reference ID/Investigator# 41485
Chiba, Japan
Site Reference ID/Investigator# 56127
Chiba, Japan
Site Reference ID/Investigator# 41821
Chiba, Japan
Site Reference ID/Investigator# 41893
Chuo, Japan
Site Reference ID/Investigator# 41727
Ehime, Japan
Site Reference ID/Investigator# 41724
Ehime, Japan
Site Reference ID/Investigator# 41721
Ehime, Japan
Site Reference ID/Investigator# 41696
Eiheiji, Japan
Site Reference ID/Investigator# 80873
Fujieda, Japan
Site Reference ID/Investigator# 41287
Fujisawa, Japan
Site Reference ID/Investigator# 41746
Fukui, Japan
Site Reference ID/Investigator# 41550
Fukui, Japan
Site Reference ID/Investigator# 41805
Fukui, Japan
Site Reference ID/Investigator# 41693
Fukui, Japan
Site Reference ID/Investigator# 41697
Fukui, Japan
Site Reference ID/Investigator# 41694
Fukui, Japan
Site Reference ID/Investigator# 59991
Fukuoka, Japan
Site Reference ID/Investigator# 56349
Fukuoka, Japan
Site Reference ID/Investigator# 41747
Fukuoka, Japan
Site Reference ID/Investigator# 41734
Fukuoka, Japan
Site Reference ID/Investigator# 56350
Fukuoka, Japan
Site Reference ID/Investigator# 59987
Fukuoka, Japan
Site Reference ID/Investigator# 41476
Fukuoka, Japan
Site Reference ID/Investigator# 41812
Fukuoka, Japan
Site Reference ID/Investigator# 41607
Fukuoka, Japan
Site Reference ID/Investigator# 41796
Fukuoka, Japan
Site Reference ID/Investigator# 41326
Fukuoka, Japan
Site Reference ID/Investigator# 41731
Fukuoka, Japan
Site Reference ID/Investigator# 41604
Fukuoka, Japan
Site Reference ID/Investigator# 41745
Fukushima, Japan
Site Reference ID/Investigator# 41825
Fukushima, Japan
Site Reference ID/Investigator# 56095
Fukushima, Japan
Site Reference ID/Investigator# 41824
Fukushima, Japan
Site Reference ID/Investigator# 56242
Fukushima, Japan
Site Reference ID/Investigator# 41818
Fukushima, Japan
Site Reference ID/Investigator# 56330
Fukushima, Japan
Site Reference ID/Investigator# 41758
Fukushima, Japan
Site Reference ID/Investigator# 41757
Fukushima, Japan
Site Reference ID/Investigator# 41302
Gifu, Japan
Site Reference ID/Investigator# 41322
Gifu, Japan
Site Reference ID/Investigator# 56103
Gifu, Japan
Site Reference ID/Investigator# 41774
Gifu, Japan
Site Reference ID/Investigator# 41306
Gifu, Japan
Site Reference ID/Investigator# 41309
Gifu, Japan
Site Reference ID/Investigator# 59989
Gifu, Japan
Site Reference ID/Investigator# 41301
Gifu, Japan
Site Reference ID/Investigator# 56207
Gunma, Japan
Site Reference ID/Investigator# 59986
Gunma, Japan
Site Reference ID/Investigator# 41830
Gunma, Japan
Site Reference ID/Investigator# 56122
Gunma, Japan
Site Reference ID/Investigator# 59997
Gunma, Japan
Site Reference ID/Investigator# 56123
Gunma, Japan
Site Reference ID/Investigator# 41828
Hakodate, Japan
Site Reference ID/Investigator# 59992
Hamamatsu, Japan
Site Reference ID/Investigator# 41304
Hamamatsu, Japan
Site Reference ID/Investigator# 41303
Hamamatsu, Japan
Site Reference ID/Investigator# 80895
Hamamatsu, Japan
Site Reference ID/Investigator# 56135
Hannan, Japan
Site Reference ID/Investigator# 56198
Higashihiroshima, Japan
Site Reference ID/Investigator# 41748
Himeji, Japan
Site Reference ID/Investigator# 41917
Himeji, Japan
Site Reference ID/Investigator# 41668
Hirakata, Japan
Site Reference ID/Investigator# 41915
Hirosaki, Japan
Site Reference ID/Investigator# 56197
Hiroshima, Japan
Site Reference ID/Investigator# 41717
Hiroshima, Japan
Site Reference ID/Investigator# 41716
Hiroshima, Japan
Site Reference ID/Investigator# 41712
Hiroshima, Japan
Site Reference ID/Investigator# 41753
Hiroshima, Japan
Site Reference ID/Investigator# 41713
Hiroshima, Japan
Site Reference ID/Investigator# 41715
Hiroshima, Japan
Site Reference ID/Investigator# 41773
Hiroshima, Japan
Site Reference ID/Investigator# 56346
Hiroshima, Japan
Site Reference ID/Investigator# 56347
Hiroshima, Japan
Site Reference ID/Investigator# 59988
Hiroshima, Japan
Site Reference ID/Investigator# 41833
Hiroshima, Japan
Site Reference ID/Investigator# 41835
Hiroshima, Japan
Site Reference ID/Investigator# 59999
Hiroshima, Japan
Site Reference ID/Investigator# 60013
Hiroshima, Japan
Site Reference ID/Investigator# 60017
Hiroshima, Japan
Site Reference ID/Investigator# 60018
Hiroshima, Japan
Site Reference ID/Investigator# 56196
Hiroshima, Japan
Site Reference ID/Investigator# 41714
Hiroshima, Japan
Site Reference ID/Investigator# 41837
Hokkaido, Japan
Site Reference ID/Investigator# 41827
Hokkaido, Japan
Site Reference ID/Investigator# 41829
Hokkaido, Japan
Site Reference ID/Investigator# 41844
Hokkaido, Japan
Site Reference ID/Investigator# 41838
Hokkaido, Japan
Site Reference ID/Investigator# 41842
Hokkaido, Japan
Site Reference ID/Investigator# 41832
Hokkaido, Japan
Site Reference ID/Investigator# 67144
Hokkaido, Japan
Site Reference ID/Investigator# 41847
Hokkaido, Japan
Site Reference ID/Investigator# 56327
Hokkaido, Japan
Site Reference ID/Investigator# 64813
Hokkaido, Japan
Site Reference ID/Investigator# 60014
Hokkaido, Japan
Site Reference ID/Investigator# 41929
Hokkaido, Japan
Site Reference ID/Investigator# 56109
Hokkaido, Japan
Site Reference ID/Investigator# 56206
Hokkaido, Japan
Site Reference ID/Investigator# 64802
Hokkaido, Japan
Site Reference ID/Investigator# 71456
Hokkaido, Japan
Site Reference ID/Investigator# 41852
Hokkaido, Japan
Site Reference ID/Investigator# 56146
Hyogo, Japan
Site Reference ID/Investigator# 56342
Hyogo, Japan
Site Reference ID/Investigator# 41683
Hyogo, Japan
Site Reference ID/Investigator# 41750
Hyogo, Japan
Site Reference ID/Investigator# 56143
Hyogo, Japan
Site Reference ID/Investigator# 56144
Hyogo, Japan
Site Reference ID/Investigator# 41687
Hyogo, Japan
Site Reference ID/Investigator# 67149
Hyogo, Japan
Site Reference ID/Investigator# 41771
Hyogo, Japan
Site Reference ID/Investigator# 56343
Hyogo, Japan
Site Reference ID/Investigator# 41846
Hyogo, Japan
Site Reference ID/Investigator# 41691
Hyogo, Japan
Site Reference ID/Investigator# 60015
Hyogo, Japan
Site Reference ID/Investigator# 41481
Hyogo, Japan
Site Reference ID/Investigator# 56142
Hyogo, Japan
Site Reference ID/Investigator# 41848
Ibaraki, Japan
Site Reference ID/Investigator# 41849
Ibaraki, Japan
Site Reference ID/Investigator# 41858
Ibaraki, Japan
Site Reference ID/Investigator# 41908
Ichikawa, Japan
Site Reference ID/Investigator# 41293
Ichinomiya, Japan
Site Reference ID/Investigator# 56229
Ichinomiya, Japan
Site Reference ID/Investigator# 56333
Ichinomiya, Japan
Site Reference ID/Investigator# 56137
Ikoma, Japan
Site Reference ID/Investigator# 56226
Inabe, Japan
Site Reference ID/Investigator# 56120
Inashiki, Japan
Site Reference ID/Investigator# 80893
Inzai, Japan
Site Reference ID/Investigator# 41740
Isahaya, Japan
Site Reference ID/Investigator# 56230
Isesaki, Japan
Site Reference ID/Investigator# 41543
Ishikawa, Japan
Site Reference ID/Investigator# 41695
Ishikawa, Japan
Site Reference ID/Investigator# 41920
Ishikawa, Japan
Site Reference ID/Investigator# 41330
Ishikawa, Japan
Site Reference ID/Investigator# 41889
Iwafune, Japan
Site Reference ID/Investigator# 80916
Iwakuni, Japan
Site Reference ID/Investigator# 56348
Iwakuni, Japan
Site Reference ID/Investigator# 41914
Iwate, Japan
Site Reference ID/Investigator# 59998
Iwate, Japan
Site Reference ID/Investigator# 56195
Izumo, Japan
Site Reference ID/Investigator# 41704
Izumo, Japan
Site Reference ID/Investigator# 41719
Izumo, Japan
Site Reference ID/Investigator# 41294
Izunokuni, Japan
Site Reference ID/Investigator# 41299
Izunokuni, Japan
Site Reference ID/Investigator# 41300
Izunokuni, Japan
Site Reference ID/Investigator# 60006
Joetsu, Japan
Site Reference ID/Investigator# 56201
Kagawa, Japan
Site Reference ID/Investigator# 56200
Kagawa, Japan
Site Reference ID/Investigator# 41725
Kagawa, Japan
Site Reference ID/Investigator# 41720
Kagawa, Japan
Site Reference ID/Investigator# 67145
Kagoshima, Japan
Site Reference ID/Investigator# 41737
Kagoshima, Japan
Site Reference ID/Investigator# 64805
Kanagawa, Japan
Site Reference ID/Investigator# 41856
Kanagawa, Japan
Site Reference ID/Investigator# 41283
Kanagawa, Japan
Site Reference ID/Investigator# 56250
Kanagawa, Japan
Site Reference ID/Investigator# 60011
Kanagawa, Japan
Site Reference ID/Investigator# 41284
Kanagawa, Japan
Site Reference ID/Investigator# 41815
Kanagawa, Japan
Site Reference ID/Investigator# 56098
Kanagawa, Japan
Site Reference ID/Investigator# 41452
Kanagawa, Japan
Site Reference ID/Investigator# 41854
Kanagawa, Japan
Site Reference ID/Investigator# 41862
Kanagawa, Japan
Site Reference ID/Investigator# 41451
Kanagawa, Japan
Site Reference ID/Investigator# 68629
Kanagawa, Japan
Site Reference ID/Investigator# 41699
Kanazawa, Japan
Site Reference ID/Investigator# 41762
Kariya, Japan
Site Reference ID/Investigator# 41461
Kashihara, Japan
Site Reference ID/Investigator# 41486
Kashiwa, Japan
Site Reference ID/Investigator# 41784
Kawagoe, Japan
Site Reference ID/Investigator# 41484
Kawagoe, Japan
Site Reference ID/Investigator# 41482
Kawagoe, Japan
Site Reference ID/Investigator# 71453
Kawasaki, Japan
Site Reference ID/Investigator# 41280
Kawasaki, Japan
Site Reference ID/Investigator# 80880
Kawasaki, Japan
Site Reference ID/Investigator# 41279
Kawasaki, Japan
Site Reference ID/Investigator# 41281
Kawasaki, Japan
Site Reference ID/Investigator# 41282
Kawasaki, Japan
Site Reference ID/Investigator# 41269
Kisarazu, Japan
Site Reference ID/Investigator# 80892
Kitakyushu, Japan
Site Reference ID/Investigator# 68626
Kitakyushu, Japan
Site Reference ID/Investigator# 41735
Kitakyushu, Japan
Site Reference ID/Investigator# 41733
Kitakyushu, Japan
Site Reference ID/Investigator# 71454
Kitakyushu, Japan
Site Reference ID/Investigator# 80914
Kobe, Japan
Site Reference ID/Investigator# 56090
Kobe, Japan
Site Reference ID/Investigator# 56145
Kobe, Japan
Site Reference ID/Investigator# 80874
Kobe, Japan
Site Reference ID/Investigator# 56264
Kobe, Japan
Site Reference ID/Investigator# 41686
Kobe, Japan
Site Reference ID/Investigator# 41544
Kobe, Japan
Site Reference ID/Investigator# 41471
Kobe, Japan
Site Reference ID/Investigator# 41472
Kobe, Japan
Site Reference ID/Investigator# 80883
Kobe, Japan
Site Reference ID/Investigator# 41548
Kochi, Japan
Site Reference ID/Investigator# 41480
Kochi, Japan
Site Reference ID/Investigator# 89493
Kofu, Japan
Site Reference ID/Investigator# 60003
Komaki, Japan
Site Reference ID/Investigator# 67153
Komoro, Japan
Site Reference ID/Investigator# 41817
Konan, Japan
Site Reference ID/Investigator# 41819
Koriyama, Japan
Site Reference ID/Investigator# 41798
Koriyama, Japan
Site Reference ID/Investigator# 41262
Koshigaya, Japan
Site Reference ID/Investigator# 56263
Kudamatsu, Japan
Site Reference ID/Investigator# 56087
Kumamoto, Japan
Site Reference ID/Investigator# 56351
Kumamoto, Japan
Site Reference ID/Investigator# 60001
Kurashiki, Japan
Site Reference ID/Investigator# 41903
Kurashiki, Japan
Site Reference ID/Investigator# 41904
Kurashiki, Japan
Site Reference ID/Investigator# 41926
Kurashiki, Japan
Site Reference ID/Investigator# 41467
Kurashiki, Japan
Site Reference ID/Investigator# 41718
Kure, Japan
Site Reference ID/Investigator# 41689
Kurobe, Japan
Site Reference ID/Investigator# 41460
Kurume, Japan
Site Reference ID/Investigator# 56202
Kurume, Japan
Site Reference ID/Investigator# 41839
Kushiro, Japan
Site Reference ID/Investigator# 56344
Kyoto, Japan
Site Reference ID/Investigator# 41905
Kyoto, Japan
Site Reference ID/Investigator# 60005
Kyoto, Japan
Site Reference ID/Investigator# 41700
Kyoto, Japan
Site Reference ID/Investigator# 56193
Kyoto, Japan
Site Reference ID/Investigator# 41698
Kyoto, Japan
Site Reference ID/Investigator# 41801
Kyoto, Japan
Site Reference ID/Investigator# 41806
Kyoto, Japan
Site Reference ID/Investigator# 64807
Kyoto, Japan
Site Reference ID/Investigator# 41454
Kyoto, Japan
Site Reference ID/Investigator# 41705
Kyoto, Japan
Site Reference ID/Investigator# 41768
Kyoto, Japan
Site Reference ID/Investigator# 56194
Kyoto, Japan
Site Reference ID/Investigator# 41921
Kyoto, Japan
Site Reference ID/Investigator# 56259
Kyoto, Japan
Site Reference ID/Investigator# 41834
Maebashi, Japan
Site Reference ID/Investigator# 56121
Maebashi, Japan
Site Reference ID/Investigator# 67263
Maebashi, Japan
Site Reference ID/Investigator# 41831
Maebashi, Japan
Site Reference ID/Investigator# 59994
Maizuru, Japan
Site Reference ID/Investigator# 41901
Matsumoto, Japan
Site Reference ID/Investigator# 41900
Matsumoto, Japan
Site Reference ID/Investigator# 41902
Matsuyama, Japan
Site Reference ID/Investigator# 41723
Matsuyama, Japan
Site Reference ID/Investigator# 41324
Matsuyama, Japan
Site Reference ID/Investigator# 56208
Mie, Japan
Site Reference ID/Investigator# 59996
Mie, Japan
Site Reference ID/Investigator# 41308
MIE, Japan
Site Reference ID/Investigator# 41749
Mie, Japan
Site Reference ID/Investigator# 56255
Mie, Japan
Site Reference ID/Investigator# 41794
Minato, Japan
Site Reference ID/Investigator# 41608
Minato, Japan
Site Reference ID/Investigator# 41760
Mito, Japan
Site Reference ID/Investigator# 41855
Miyagi, Japan
Site Reference ID/Investigator# 56111
Miyagi, Japan
Site Reference ID/Investigator# 56112
Miyagi, Japan
Site Reference ID/Investigator# 41871
Miyagi, Japan
Site Reference ID/Investigator# 41865
Miyagi, Japan
Site Reference ID/Investigator# 56329
Miyagi, Japan
Site Reference ID/Investigator# 41859
Miyagi, Japan
Site Reference ID/Investigator# 41861
Miyagi, Japan
Site Reference ID/Investigator# 41919
Miyazaki, Japan
Site Reference ID/Investigator# 41790
Miyazaki, Japan
Site Reference ID/Investigator# 60021
Miyazaki, Japan
Site Reference ID/Investigator# 41475
Miyazaki, Japan
Site Reference ID/Investigator# 41791
Miyazaki, Japan
Site Reference ID/Investigator# 41458
Morioka, Japan
Site Reference ID/Investigator# 41545
Nagakute, Japan
Site Reference ID/Investigator# 41462
Nagakute, Japan
Site Reference ID/Investigator# 41863
Nagano, Japan
Site Reference ID/Investigator# 41797
Nagano, Japan
Site Reference ID/Investigator# 56124
Nagano, Japan
Site Reference ID/Investigator# 41870
Nagano, Japan
Site Reference ID/Investigator# 41866
Nagano, Japan
Site Reference ID/Investigator# 64808
Nagaokakyo, Japan
Site Reference ID/Investigator# 41864
Nagasaki, Japan
Site Reference ID/Investigator# 41464
Nagasaki, Japan
Site Reference ID/Investigator# 41728
Nagasaki, Japan
Site Reference ID/Investigator# 41736
Nagasaki, Japan
Site Reference ID/Investigator# 41730
Nagasaki, Japan
Site Reference ID/Investigator# 41877
Nagasaki, Japan
Site Reference ID/Investigator# 41756
Nagasaki, Japan
Site Reference ID/Investigator# 41789
Nagasaki, Japan
Site Reference ID/Investigator# 56130
Nagoya, Japan
Site Reference ID/Investigator# 41744
Nagoya, Japan
Site Reference ID/Investigator# 41909
Nagoya, Japan
Site Reference ID/Investigator# 41290
Nagoya, Japan
Site Reference ID/Investigator# 41289
Nagoya, Japan
Site Reference ID/Investigator# 41910
Nagoya, Japan
Site Reference ID/Investigator# 41549
Nagoya, Japan
Site Reference ID/Investigator# 41802
Nagoya, Japan
Site Reference ID/Investigator# 41804
Nanao, Japan
Site Reference ID/Investigator# 41478
Nankoku, Japan
Site Reference ID/Investigator# 59985
Nara, Japan
Site Reference ID/Investigator# 41710
Nara, Japan
Site Reference ID/Investigator# 56227
Nara, Japan
Site Reference ID/Investigator# 56091
Nara, Japan
Site Reference ID/Investigator# 80896
Nayori, Japan
Site Reference ID/Investigator# 67152
Nigata, Japan
Site Reference ID/Investigator# 56326
Niigata, Japan
Site Reference ID/Investigator# 41793
Niigata, Japan
Site Reference ID/Investigator# 41879
Niigata, Japan
Site Reference ID/Investigator# 41873
Niigata, Japan
Site Reference ID/Investigator# 64812
Niigata, Japan
Site Reference ID/Investigator# 41741
Nishihara, Japan
Site Reference ID/Investigator# 41682
Nishinomiya, Japan
Site Reference ID/Investigator# 41690
Nishinomiya, Japan
Site Reference ID/Investigator# 80877
Nishio, Japan
Site Reference ID/Investigator# 67264
Nisshin, Japan
Site Reference ID/Investigator# 41843
Obihiro, Japan
Site Reference ID/Investigator# 41841
Obihiro, Japan
Site Reference ID/Investigator# 41857
Odawara, Japan
Site Reference ID/Investigator# 41766
Ogaki, Japan
Site Reference ID/Investigator# 56203
Oita, Japan
Site Reference ID/Investigator# 41906
Oita, Japan
Site Reference ID/Investigator# 80876
Okawa, Japan
Site Reference ID/Investigator# 41709
Okayama, Japan
Site Reference ID/Investigator# 41703
Okayama, Japan
Site Reference ID/Investigator# 41701
Okayama, Japan
Site Reference ID/Investigator# 60019
Okayama, Japan
Site Reference ID/Investigator# 64809
Okayama, Japan
Site Reference ID/Investigator# 41702
Okayama, Japan
Site Reference ID/Investigator# 41918
Okayama, Japan
Site Reference ID/Investigator# 56205
Osaka, Japan
Site Reference ID/Investigator# 80882
Osaka, Japan
Site Reference ID/Investigator# 59990
Osaka, Japan
Site Reference ID/Investigator# 41664
Osaka, Japan
Site Reference ID/Investigator# 67143
Osaka, Japan
Site Reference ID/Investigator# 41662
Osaka, Japan
Site Reference ID/Investigator# 41874
Osaka, Japan
Site Reference ID/Investigator# 41875
Osaka, Japan
Site Reference ID/Investigator# 41667
Osaka, Japan
Site Reference ID/Investigator# 56256
Osaka, Japan
Site Reference ID/Investigator# 41878
Osaka, Japan
Site Reference ID/Investigator# 41743
Osaka, Japan
Site Reference ID/Investigator# 41310
Osaka, Japan
Site Reference ID/Investigator# 41669
Osaka, Japan
Site Reference ID/Investigator# 41663
Osaka, Japan
Site Reference ID/Investigator# 41670
Osaka, Japan
Site Reference ID/Investigator# 41671
Osaka, Japan
Site Reference ID/Investigator# 41672
Osaka, Japan
Site Reference ID/Investigator# 41675
Osaka, Japan
Site Reference ID/Investigator# 41674
Osaka, Japan
Site Reference ID/Investigator# 67148
Osaka, Japan
Site Reference ID/Investigator# 41673
Osaka, Japan
Site Reference ID/Investigator# 41676
Osaka, Japan
Site Reference ID/Investigator# 41678
Osaka, Japan
Site Reference ID/Investigator# 41679
Osaka, Japan
Site Reference ID/Investigator# 41680
Osaka, Japan
Site Reference ID/Investigator# 56257
Osaka, Japan
Site Reference ID/Investigator# 56325
Osaka, Japan
Site Reference ID/Investigator# 56134
Osaka, Japan
Site Reference ID/Investigator# 41809
Osaka, Japan
Site Reference ID/Investigator# 80878
Osaka, Japan
Site Reference ID/Investigator# 41456
Osaka, Japan
Site Reference ID/Investigator# 41799
Osaka, Japan
Site Reference ID/Investigator# 41455
Osaka, Japan
Site Reference ID/Investigator# 56341
Osaka, Japan
Site Reference ID/Investigator# 41811
Osaka, Japan
Site Reference ID/Investigator# 80915
Osaka, Japan
Site Reference ID/Investigator# 67151
Osaka, Japan
Site Reference ID/Investigator# 41466
Osaka, Japan
Site Reference ID/Investigator# 41477
Osaka, Japan
Site Reference ID/Investigator# 56088
Osaka, Japan
Site Reference ID/Investigator# 41786
Osaka, Japan
Site Reference ID/Investigator# 41469
Osakasayama, Japan
Site Reference ID/Investigator# 41457
Osakasayama, Japan
Site Reference ID/Investigator# 56113
Osaki, Japan
Site Reference ID/Investigator# 41840
Osaki, Japan
Site Reference ID/Investigator# 41867
Osaki, Japan
Site Reference ID/Investigator# 41869
Osaki, Japan
Site Reference ID/Investigator# 41708
Otsu, Japan
Site Reference ID/Investigator# 56345
Otsu, Japan
Site Reference ID/Investigator# 80875
Rifu, Japan
Site Reference ID/Investigator# 41729
Saga, Japan
Site Reference ID/Investigator# 41876
Saga, Japan
Site Reference ID/Investigator# 41732
Saga, Japan
Site Reference ID/Investigator# 41323
Sagamihara, Japan
Site Reference ID/Investigator# 41468
Sagamihara, Kanagawa, Japan
Site Reference ID/Investigator# 41278
Saitama, Japan
Site Reference ID/Investigator# 64810
Saitama, Japan
Site Reference ID/Investigator# 41329
Saitama, Japan
Site Reference ID/Investigator# 64804
Saitama, Japan
Site Reference ID/Investigator# 60009
Saitama, Japan
Site Reference ID/Investigator# 56099
Saitama, Japan
Site Reference ID/Investigator# 41256
Saitama, Japan
Site Reference ID/Investigator# 41257
Saitama, Japan
Site Reference ID/Investigator# 41261
Saitama, Japan
Site Reference ID/Investigator# 56249
Saitama, Japan
Site Reference ID/Investigator# 41264
Saitama, Japan
Site Reference ID/Investigator# 41265
Saitama, Japan
Site Reference ID/Investigator# 56094
Saitama, Japan
Site Reference ID/Investigator# 56100
Saitama, Japan
Site Reference ID/Investigator# 41267
Saitama, Japan
Site Reference ID/Investigator# 41274
Saitama, Japan
Site Reference ID/Investigator# 64803
Saitama, Japan
Site Reference ID/Investigator# 41270
Saitama, Japan
Site Reference ID/Investigator# 41271
Saitama, Japan
Site Reference ID/Investigator# 41272
Saitama, Japan
Site Reference ID/Investigator# 41266
Saitama, Japan
Site Reference ID/Investigator# 56136
Sakai, Japan
Site Reference ID/Investigator# 41603
Sakai, Japan
Site Reference ID/Investigator# 41868
Saku, Japan
Site Reference ID/Investigator# 41826
Sakura, Japan
Site Reference ID/Investigator# 56107
Sapporo, Japan
Site Reference ID/Investigator# 56209
Sapporo, Japan
Site Reference ID/Investigator# 56108
Sapporo, Japan
Site Reference ID/Investigator# 41853
Sapporo, Japan
Site Reference ID/Investigator# 80884
Sapporo, Japan
Site Reference ID/Investigator# 56105
Sapporo, Japan
Site Reference ID/Investigator# 41850
Sapporo, Japan
Site Reference ID/Investigator# 41763
Sapporo, Japan
Site Reference ID/Investigator# 41739
Sasebo, Japan
Site Reference ID/Investigator# 41755
Sasebo, Japan
Site Reference ID/Investigator# 80889
Sendai, Japan
Site Reference ID/Investigator# 41813
Sendai, Japan
Site Reference ID/Investigator# 41605
Sendai, Japan
Site Reference ID/Investigator# 41930
Sendai, Japan
Site Reference ID/Investigator# 41814
Sendai, Japan
Site Reference ID/Investigator# 41546
Seto, Japan
Site Reference ID/Investigator# 41707
Shiga, Japan
Site Reference ID/Investigator# 59993
Shiga, Japan
Site Reference ID/Investigator# 41754
Shiga, Japan
Site Reference ID/Investigator# 41922
Shiga, Japan
Site Reference ID/Investigator# 41553
Shiga, Japan
Site Reference ID/Investigator# 60007
Shimane, Japan
Site Reference ID/Investigator# 41885
Shimotsuke, Japan
Site Reference ID/Investigator# 41884
Shimotsuke, Japan
Site Reference ID/Investigator# 41292
Shizuoka, Japan
Site Reference ID/Investigator# 41808
Shizuoka, Japan
Site Reference ID/Investigator# 41880
Shizuoka, Japan
Site Reference ID/Investigator# 41881
Shizuoka, Japan
Site Reference ID/Investigator# 56132
Shizuoka, Japan
Site Reference ID/Investigator# 41872
Shizuoka, Japan
Site Reference ID/Investigator# 41296
Shizuoka, Japan
Site Reference ID/Investigator# 68628
Shizuoka, Japan
Site Reference ID/Investigator# 41295
Shizuoka, Japan
Site Reference ID/Investigator# 56133
Shizuoka, Japan
Site Reference ID/Investigator# 56101
Shizuoka, Japan
Site Reference ID/Investigator# 41328
Shizuoka, Japan
Site Reference ID/Investigator# 56253
Shizuoka, Japan
Site Reference ID/Investigator# 56339
Shizuoka, Japan
Site Reference ID/Investigator# 41298
Shizuoka, Japan
Site Reference ID/Investigator# 41479
Shizuoka, Japan
Site Reference ID/Investigator# 41772
Shizuoka, Japan
Site Reference ID/Investigator# 41928
Shunan, Japan
Site Reference ID/Investigator# 80886
Soka, Japan
Site Reference ID/Investigator# 41552
Takamatsu, Japan
Site Reference ID/Investigator# 41551
Takamatsu, Japan
Site Reference ID/Investigator# 41761
Takamatsu, Japan
Site Reference ID/Investigator# 41836
Takasaki, Japan
Site Reference ID/Investigator# 41767
Takatsuki, Japan
Site Reference ID/Investigator# 41665
Takatsuki, Japan
Site Reference ID/Investigator# 41666
Takatsuki, Japan
Site Reference ID/Investigator# 56138
Tanabe, Japan
Site Reference ID/Investigator# 41465
Tenri, Japan
Site Reference ID/Investigator# 41752
Tenri, Japan
Site Reference ID/Investigator# 41803
Tokushima, Japan
Site Reference ID/Investigator# 56222
Tokushima, Japan
Site Reference ID/Investigator# 67146
Tokushima, Japan
Site Reference ID/Investigator# 41742
Tokyo, Japan
Site Reference ID/Investigator# 41449
Tokyo, Japan
Site Reference ID/Investigator# 41892
Tokyo, Japan
Site Reference ID/Investigator# 41610
Tokyo, Japan
Site Reference ID/Investigator# 41444
Tokyo, Japan
Site Reference ID/Investigator# 41891
Tokyo, Japan
Site Reference ID/Investigator# 56243
Tokyo, Japan
Site Reference ID/Investigator# 56244
Tokyo, Japan
Site Reference ID/Investigator# 56245
Tokyo, Japan
Site Reference ID/Investigator# 56246
Tokyo, Japan
Site Reference ID/Investigator# 56247
Tokyo, Japan
Site Reference ID/Investigator# 56248
Tokyo, Japan
Site Reference ID/Investigator# 41445
Tokyo, Japan
Site Reference ID/Investigator# 41459
Tokyo, Japan
Site Reference ID/Investigator# 41206
Tokyo, Japan
Site Reference ID/Investigator# 41259
Tokyo, Japan
Site Reference ID/Investigator# 41890
Tokyo, Japan
Site Reference ID/Investigator# 41888
Tokyo, Japan
Site Reference ID/Investigator# 41887
Tokyo, Japan
Site Reference ID/Investigator# 41886
Tokyo, Japan
Site Reference ID/Investigator# 56104
Tokyo, Japan
Site Reference ID/Investigator# 41924
Tokyo, Japan
Site Reference ID/Investigator# 41602
Tokyo, Japan
Site Reference ID/Investigator# 56125
Tokyo, Japan
Site Reference ID/Investigator# 56126
Tokyo, Japan
Site Reference ID/Investigator# 41883
Tokyo, Japan
Site Reference ID/Investigator# 41925
Tokyo, Japan
Site Reference ID/Investigator# 41764
Tokyo, Japan
Site Reference ID/Investigator# 41765
Tokyo, Japan
Site Reference ID/Investigator# 41547
Tokyo, Japan
Site Reference ID/Investigator# 41268
Tokyo, Japan
Site Reference ID/Investigator# 56102
Tokyo, Japan
Site Reference ID/Investigator# 56225
Tokyo, Japan
Site Reference ID/Investigator# 41447
Tokyo, Japan
Site Reference ID/Investigator# 41448
Tokyo, Japan
Site Reference ID/Investigator# 41897
Tokyo, Japan
Site Reference ID/Investigator# 41246
Tokyo, Japan
Site Reference ID/Investigator# 41907
Tokyo, Japan
Site Reference ID/Investigator# 41273
Tokyo, Japan
Site Reference ID/Investigator# 41911
Tokyo, Japan
Site Reference ID/Investigator# 41446
Tokyo, Japan
Site Reference ID/Investigator# 60008
Tokyo, Japan
Site Reference ID/Investigator# 41245
Tokyo, Japan
Site Reference ID/Investigator# 41244
Tokyo, Japan
Site Reference ID/Investigator# 41912
Tokyo, Japan
Site Reference ID/Investigator# 41243
Tokyo, Japan
Site Reference ID/Investigator# 41242
Tokyo, Japan
Site Reference ID/Investigator# 80885
Tokyo, Japan
Site Reference ID/Investigator# 26162
Tokyo, Japan
Site Reference ID/Investigator# 41241
Tokyo, Japan
Site Reference ID/Investigator# 41240
Tokyo, Japan
Site Reference ID/Investigator# 41239
Tokyo, Japan
Site Reference ID/Investigator# 41230
Tokyo, Japan
Site Reference ID/Investigator# 41792
Tokyo, Japan
Site Reference ID/Investigator# 41229
Tokyo, Japan
Site Reference ID/Investigator# 41228
Tokyo, Japan
Site Reference ID/Investigator# 41913
Tokyo, Japan
Site Reference ID/Investigator# 56093
Tokyo, Japan
Site Reference ID/Investigator# 41227
Tokyo, Japan
Site Reference ID/Investigator# 41474
Tokyo, Japan
Site Reference ID/Investigator# 41226
Tokyo, Japan
Site Reference ID/Investigator# 41470
Tokyo, Japan
Site Reference ID/Investigator# 41225
Tokyo, Japan
Site Reference ID/Investigator# 60000
Tokyo, Japan
Site Reference ID/Investigator# 56211
Tokyo, Japan
Site Reference ID/Investigator# 60002
Tokyo, Japan
Site Reference ID/Investigator# 41896
Tokyo, Japan
Site Reference ID/Investigator# 41443
Tokyo, Japan
Site Reference ID/Investigator# 41795
Tokyo, Japan
Site Reference ID/Investigator# 56092
Tokyo, Japan
Site Reference ID/Investigator# 56331
Tokyo, Japan
Site Reference ID/Investigator# 80888
Tokyo, Japan
Site Reference ID/Investigator# 41882
Tokyo, Japan
Site Reference ID/Investigator# 41211
Tokyo, Japan
Site Reference ID/Investigator# 41209
Tokyo, Japan
Site Reference ID/Investigator# 41224
Tokyo, Japan
Site Reference ID/Investigator# 41223
Tokyo, Japan
Site Reference ID/Investigator# 41222
Tokyo, Japan
Site Reference ID/Investigator# 41214
Tokyo, Japan
Site Reference ID/Investigator# 41213
Tokyo, Japan
Site Reference ID/Investigator# 41210
Tokyo, Japan
Site Reference ID/Investigator# 41212
Tokyo, Japan
Site Reference ID/Investigator# 41208
Tokyo, Japan
Site Reference ID/Investigator# 60020
Tokyo, Japan
Site Reference ID/Investigator# 41787
Tonami, Japan
Site Reference ID/Investigator# 67142
Toride, Japan
Site Reference ID/Investigator# 56262
Tottori, Japan
Site Reference ID/Investigator# 41685
Toyama, Japan
Site Reference ID/Investigator# 56097
Toyama, Japan
Site Reference ID/Investigator# 64806
Toyama, Japan
Site Reference ID/Investigator# 41692
Toyama, Japan
Site Reference ID/Investigator# 56258
Toyama, Japan
Site Reference ID/Investigator# 41609
Toyama, Japan
Site Reference ID/Investigator# 41325
Toyama, Japan
Site Reference ID/Investigator# 56192
Toyama, Japan
Site Reference ID/Investigator# 41688
Toyama, Japan
Site Reference ID/Investigator# 41783
Toyama, Japan
Site Reference ID/Investigator# 60004
Toyama, Japan
Site Reference ID/Investigator# 67147
Toyoake, Japan
Site Reference ID/Investigator# 60010
Toyoake, Japan
Site Reference ID/Investigator# 41288
Toyoake, Japan
Site Reference ID/Investigator# 41307
Toyohashi, Japan
Site Reference ID/Investigator# 56228
Toyooka, Japan
Site Reference ID/Investigator# 41845
Toyooka, Japan
Site Reference ID/Investigator# 56089
Toyota, Japan
Site Reference ID/Investigator# 56114
Tsukuba, Japan
Site Reference ID/Investigator# 56115
Tsukuba, Japan
Site Reference ID/Investigator# 56204
Tsuyama, Japan
Site Reference ID/Investigator# 56210
Uji, Japan
Site Reference ID/Investigator# 41759
Urayasu, Japan
Site Reference ID/Investigator# 41453
Urayasu, Japan
Site Reference ID/Investigator# 41923
Utazu, Japan
Site Reference ID/Investigator# 41807
Utazu, Japan
Site Reference ID/Investigator# 80913
Utsunomiya, Japan
Site Reference ID/Investigator# 41677
Wakayama, Japan
Site Reference ID/Investigator# 41681
Wakayama, Japan
Site Reference ID/Investigator# 41770
Wakayama, Japan
Site Reference ID/Investigator# 41463
Wakayama, Japan
Site Reference ID/Investigator# 80890
Yachiyo, Japan
Site Reference ID/Investigator# 80891
Yachiyo, Japan
Site Reference ID/Investigator# 80894
Yachiyo, Japan
Site Reference ID/Investigator# 41898
Yamagata, Japan
Site Reference ID/Investigator# 56328
Yamagata, Japan
Site Reference ID/Investigator# 56110
Yamagata, Japan
Site Reference ID/Investigator# 41895
Yamagata, Japan
Site Reference ID/Investigator# 41894
Yamagata, Japan
Site Reference ID/Investigator# 41711
Yamaguchi, Japan
Site Reference ID/Investigator# 56223
Yamaguchi, Japan
Site Reference ID/Investigator# 56199
Yamaguchi, Japan
Site Reference ID/Investigator# 41726
Yamaguchi, Japan
Site Reference ID/Investigator# 41722
Yamaguchi, Japan
Site Reference ID/Investigator# 41899
Yamanashi, Japan
Site Reference ID/Investigator# 41297
Yatomi, Japan
Site Reference ID/Investigator# 41277
Yokohama, Japan
Site Reference ID/Investigator# 56332
Yokohama, Japan
Site Reference ID/Investigator# 56128
Yokohama, Japan
Site Reference ID/Investigator# 41860
Yokohama, Japan
Site Reference ID/Investigator# 71459
Yokohama, Japan
Site Reference ID/Investigator# 41286
Yokohama, Japan
Site Reference ID/Investigator# 41275
Yokohama, Japan
Site Reference ID/Investigator# 41276
Yokohama, Japan
Site Reference ID/Investigator# 41916
Yokohama, Japan
Site Reference ID/Investigator# 41285
Yokohama, Japan
Site Reference ID/Investigator# 41450
Yokohama, Japan
Site Reference ID/Investigator# 80917
Yokohama, Japan
Site Reference ID/Investigator# 41291
Yokosuka, Japan
Site Reference ID/Investigator# 71458
Yokosuka, Japan
Site Reference ID/Investigator# 41706
Yonago, Japan
Site Reference ID/Investigator# 41738
Yufu, Japan
Sponsors and Collaborators
AbbVie (prior sponsor, Abbott)
Investigators
Study Director: Yuji Yamaguchi, MD Abbvie GK
  More Information

Additional Information:
No publications provided

Responsible Party: AbbVie ( AbbVie (prior sponsor, Abbott) )
ClinicalTrials.gov Identifier: NCT01155570     History of Changes
Other Study ID Numbers: P12-077
Study First Received: June 30, 2010
Results First Received: July 23, 2013
Last Updated: September 30, 2013
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by AbbVie:
Psoriasis

Additional relevant MeSH terms:
Arthritis, Psoriatic
Psoriasis
Spondylarthropathies
Spondylarthritis
Spondylitis
Spinal Diseases
Bone Diseases
Musculoskeletal Diseases
Arthritis
Joint Diseases
Skin Diseases, Papulosquamous
Skin Diseases

ClinicalTrials.gov processed this record on September 16, 2014