Congestive Heart Failure: Causes of Sudden Worsening

The recruitment status of this study is unknown because the information has not been verified recently.

Verified February 2010 by University Hospital Hradec Kralove.
Recruitment status was Recruiting

Sponsor:

Information provided by:

University Hospital Hradec Kralove

ClinicalTrials.gov Identifier:

NCT01081925

First received: March 4, 2010

Last updated: NA

Last verified: February 2010

History: No changes posted

Purpose

The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.

Condition
Congestive Heart Failure

Study Type:	Observational
Study Design:	Observational Model: Case-Only Time Perspective: Cross-Sectional
Official Title:	Congestive Heart Failure: Causes of Sudden Worsening

Resource links provided by NLM:

MedlinePlus related topics: Heart Failure

U.S. FDA Resources

Further study details as provided by University Hospital Hradec Kralove:

Estimated Enrollment:	100
Study Start Date:	February 2010
Estimated Study Completion Date:	February 2012
Estimated Primary Completion Date:	February 2012 (Final data collection date for primary outcome measure)

Groups/Cohorts
Congestive heart failure Patients suffering from sudden worsening of congestive heart failure

Detailed Description:

Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients suffering from sudden worsening of congestive heart failure, who are examined at the Emergency department or admitted to University Hospital

Criteria

Inclusion Criteria:

able to provide informed consent
aged 19 years or more
history of heart failure of at least one month
examined or hospitalized for acute dyspnea at rest or with minimal exertion
clinical signs of fluid overload defined as at least one of following:
rales
jugular venous distension
peripheral edema
pulmonary congestion on X-ray
NT-proBNP above 210 pmo/l

Exclusion Criteria:

none

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01081925

Contacts

Contact: Radek Pelouch, MD	00420495834740	pelouch@centrum.cz
Contact: Jiri Ceral, MD	00420495832652	ceral@seznam.cz

Locations

Czech Republic
University Hospital Hradec Kralove	Recruiting
Hradec Kralove, Czech Republic, 50005
Principal Investigator: Radek Pelouch
Sub-Investigator: Jiri Ceral, MD
Sub-Investigator: Miroslav Solar, MD

Sponsors and Collaborators

University Hospital Hradec Kralove

Investigators

Principal Investigator:

Radek Pelouch, MD

University Hospital Hradec Kralove

More Information

No publications provided

Responsible Party:	Pelouch Radek, MD, University Hospital Hradec Kralove
ClinicalTrials.gov Identifier:	NCT01081925 History of Changes
Other Study ID Numbers:	MSM0021620817-HKJC
Study First Received:	March 4, 2010
Last Updated:	March 4, 2010
Health Authority:	Czech Republic: Ethics Committee

Keywords provided by University Hospital Hradec Kralove:

Congestive Heart Failure
Cardiac Failure

Additional relevant MeSH terms:

Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 21, 2013

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