Trial record 1 of 1 for:    e7208
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Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2012 by Eastern Cooperative Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Pam Cogliano, Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier:
NCT01079780
First received: March 2, 2010
Last updated: September 19, 2014
Last verified: June 2012
  Purpose

RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab and ramucirumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab and ramucirumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. It is not yet know whether giving cetuximab and irinotecan hydrochloride together is more effective with or without ramucirumab in treating colorectal cancer.

PURPOSE: This randomized phase II trial is studying the side effects and how well giving cetuximab and irinotecan hydrochloride with or without ramucirumab work in treating patients with advanced colorectal cancer with progressive disease after treatment with bevacizumab-containing chemotherapy.


Condition Intervention Phase
Colorectal Cancer
Biological: cetuximab
Biological: ramucirumab
Drug: irinotecan hydrochloride
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomized Phase II Study of Irinotecan and Cetuximab With or Without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced, K-ras Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy

Resource links provided by NLM:


Further study details as provided by Eastern Cooperative Oncology Group:

Primary Outcome Measures:
  • Progression-free survival [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Response rate (complete response, partial response, stable disease) [ Designated as safety issue: No ]
  • Toxicity [ Designated as safety issue: Yes ]
  • Overall survival [ Designated as safety issue: No ]

Estimated Enrollment: 147
Study Start Date: November 2010
Estimated Primary Completion Date: June 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I
Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride over 60-90 minutes on day 1.
Biological: cetuximab
Given IV
Drug: irinotecan hydrochloride
Given IV
Experimental: Arm II
Patients receive ramucirumab IV over 60 minutes on day 1 and cetuximab and irinotecan hydrochloride as in arm I.
Biological: cetuximab
Given IV
Biological: ramucirumab
Given IV
Drug: irinotecan hydrochloride
Given IV

Detailed Description:

OBJECTIVES:

  • To evaluate the progression-free survival of patients with advanced K-ras wild-type colorectal cancer, following progression on bevacizumab-contained chemotherapy, treated with irinotecan hydrochloride and cetuximab with versus without ramucirumab as second-line therapy.
  • To evaluate the response rate in patients treated with these regimens.
  • To evaluate the grade 3-4 toxicity rates of these regimens in these patients.
  • To evaluate the overall suvival of patients treated with these regimens.

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to performance status (0 vs 1), discontinuation of oxaliplatin before disease progression (yes vs no), and time to disease progression since last treatment (≤ 6 months vs > 6 months). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride over 60-90 minutes on day 1.
  • Arm II: Patients receive ramucirumab IV over 60 minutes on day 1 and cetuximab and irinotecan hydrochloride as in arm I.

In both arms, courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for 5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the colon or rectum, including:

    • Advanced disease
    • Histologic variants of adenocarcinoma allowed
    • K-ras wild type based on either primary or metastatic tumor

      • No mutated type
  • Measurable disease
  • Must have received prior first-line therapy comprising oxaliplatin-based fluoropyrimidine-containing chemotherapy and bevacizumab for metastatic colorectal cancer
  • No more than 42 days since confirmed disease progression
  • No brain or CNS metastases

PATIENT CHARACTERISTICS:

  • Performance status 0-1
  • ANC ≥ 1,500/μL
  • Platelet count ≥ 75,000/μL
  • Hemoglobin ≥ 9 g/dL
  • Serum creatinine ≤ 1.5 times upper limit of normal (ULN) OR creatinine clearance ≥ 40 mL/min
  • Urine protein ≤ 1+ on dipstick or routine urinalysis (if ≥ 2+, a 24-hour urine collection must demonstrate < 1,000 mg of protein)
  • Total bilirubin ≤ 2.0 mg/dL
  • AST and ALT ≤ 3.0 times ULN (5.0 times ULN for patients with liver metastases)
  • INR ≤ 1.6 (≤ 3.0 for patients on warfarin and no active bleeding [i.e., no bleeding within the past 14 days])
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception during and for 3 months after completion of study therapy
  • No clinically significant (equivalent to NCI CTCAE grade 3-4) bleeding episodes within the past 3 months
  • None of the following:

    • Active infection
    • Symptomatic congestive heart failure
    • Unstable angina pectoris
    • Symptomatic or poorly controlled cardiac arrhythmia
    • Uncontrolled thrombotic or hemorrhagic disorder
  • No uncontrolled or poorly controlled hypertension despite standard medical management (e.g., consistently systolic BP > 160 mm Hg and diastolic BP > 90 mm Hg)
  • No acute arterial thrombotic events within the past 6 months, including cerebrovascular accident, transient ischemic attack, myocardial infarction, or unstable angina
  • No other cancer requiring therapy within the past 3 years except in situ carcinoma or nonmelanoma skin cancer
  • No acute or subacute intestinal obstruction
  • No history of inflammatory bowel disease requiring pharmacological and/or surgical intervention within the past 12 months
  • No known allergy to any of the treatment components

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • At least 28 days and no more than 90 days since prior bevacizumab
  • No prior therapy with drugs other than oxaliplatin and a fluoropyrimidine plus bevacizumab for colorectal cancer
  • No major surgery within the past 28 days
  • No subcutaneous venous access device placement within the past 7 days
  • Concurrent stable dose of oral anticoagulant or low-molecular weight heparin allowed
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01079780

  Hide Study Locations
Locations
United States, Alabama
UAB Comprehensive Cancer Center Recruiting
Birmingham, Alabama, United States, 35294
Contact: Clinical Trials Office - UAB Comprehensive Cancer Center    205-934-0309      
United States, Colorado
Aurora Presbyterian Hospital Recruiting
Aurora, Colorado, United States, 80012
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301-9019
Contact: Clinical Trials Office - Boulder Community Hospital    303-938-5253      
Penrose Cancer Center at Penrose Hospital Recruiting
Colorado Springs, Colorado, United States, 80933
Contact: Clinical Trials Office - Penrose Cancer Center    719-776-5275      
CCOP - Colorado Cancer Research Program Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
St. Anthony Central Hospital Recruiting
Denver, Colorado, United States, 80204
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
St. Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Presbyterian - St. Luke's Medical Center Recruiting
Denver, Colorado, United States, 80218
Contact: Clinical Trials Office - Presbyterian - St. Luke's Medical Cen    303-839-6000      
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80110
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Clinical Trials Office - Poudre Valley Hospital    970-495-8226      
Front Range Cancer Specialists Recruiting
Fort Collins, Colorado, United States, 80528
Contact: Diana C. Medgyesy, MD    970-212-7600      
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center Recruiting
Grand Junction, Colorado, United States, 81502
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Hope Cancer Care Center at Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
St. Mary - Corwin Regional Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
North Suburban Medical Center Recruiting
Thornton, Colorado, United States, 80229
Contact: Eduardo R. Pajon, MD    303-399-8020ext2261      
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Clinical Trials Office - Exempla Lutheran Medical Center    303-403-3605      
United States, Connecticut
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella, MD    734-712-1000      
Yale Cancer Center Recruiting
New Haven, Connecticut, United States, 06520-8028
Contact: Clinical Trials Office - Yale Cancer Center    203-785-5702      
United States, Georgia
Veterans Affairs Medical Center - Atlanta (Decatur) Recruiting
Decatur, Georgia, United States, 30033
Contact: Samuel N. Chan    404-728-7680      
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Mark A. Taylor, MD    912-354-6187      
United States, Illinois
Rush-Copley Cancer Care Center Recruiting
Aurora, Illinois, United States, 60504
Contact: Ronnie F. Luyun    630-499-2400      
St. Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: John W. Kugler, MD    309-243-3605      
Graham Hospital Recruiting
Canton, Illinois, United States, 61520
Contact: John W. Kugler, MD    309-243-3605      
Memorial Hospital Recruiting
Carthage, Illinois, United States, 62321
Contact: John W. Kugler, MD    309-243-3605      
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Recruiting
Chicago, Illinois, United States, 60611-3013
Contact: Clinical Trials Office - Robert H. Lurie Comprehensive Cancer    312-695-1301    cancer@northwestern.edu   
John H. Stroger, Jr. Hospital of Cook County Recruiting
Chicago, Illinois, United States, 60612-3785
Contact: Michael R. Mullane    312-864-3200      
Hematology and Oncology Associates Recruiting
Chicago, Illinois, United States, 60611
Contact: Clinical Trails Office - Hematology and Oncology Associates    312-695-1301      
Decatur Memorial Hospital Cancer Care Institute Recruiting
Decatur, Illinois, United States, 62526
Contact: Clinical Trials Office - Decatur Memorial Hospital Cancer Care    217-876-4750      
Eureka Community Hospital Recruiting
Eureka, Illinois, United States, 61530
Contact: John W. Kugler, MD    309-243-3605      
Galesburg Clinic, PC Recruiting
Galesburg, Illinois, United States, 61401
Contact: John W. Kugler, MD    309-243-3605      
Mason District Hospital Recruiting
Havana, Illinois, United States, 62644
Contact: John W. Kugler, MD    309-243-3605      
Kellogg Cancer Care Center Recruiting
Highland Park, Illinois, United States, 60035
Contact: Al B. Benson, MD, FACP    312-695-6180      
Hinsdale Hematology Oncology Associates Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Elyse C. Schneiderman, MD    630-654-1790      
Provena St. Mary's Regional Cancer Center - Kankakee Recruiting
Kankakee, Illinois, United States, 60901
Contact: Al B. Benson, MD, FACP    312-695-6180      
North Shore Oncology and Hematology Associates, Limited - Libertyville Recruiting
Libertyville, Illinois, United States, 60048
Contact: Al B. Benson, MD, FACP    312-695-6180      
McDonough District Hospital Recruiting
Macomb, Illinois, United States, 61455
Contact: John W. Kugler, MD    309-243-3605      
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus Recruiting
Moline, Illinois, United States, 61265
Contact: Costas L. Constantinou, MD    563-359-9876      
Cancer Care and Hematology Specialists of Chicagoland - Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Al B. Benson, MD, FACP    312-695-6180      
Community Cancer Center Recruiting
Normal, Illinois, United States, 61761
Contact: John W. Kugler, MD    309-243-3605      
BroMenn Regional Medical Center Recruiting
Normal, Illinois, United States, 61761
Contact: John W. Kugler, MD    309-243-3605      
Advocate Christ Medical Center Recruiting
Oak Lawn, Illinois, United States, 60453-2699
Contact: Amar Hamad    708-684-8000      
Community Hospital of Ottawa Recruiting
Ottawa, Illinois, United States, 61350
Contact: John W. Kugler, MD    309-243-3605      
Cancer Treatment Center at Pekin Hospital Recruiting
Pekin, Illinois, United States, 61554
Contact: John W. Kugler, MD    309-243-3605      
Proctor Hospital Recruiting
Peoria, Illinois, United States, 61614
Contact: John W. Kugler, MD    309-243-3605      
CCOP - Illinois Oncology Research Association Recruiting
Peoria, Illinois, United States, 61615
Contact: John W. Kugler, MD    309-243-3605      
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61636
Contact: Clinical Trials Office - Methodist Medical Center of Illinois    309-243-3000      
Oncology Hematology Associates of Central Illinois, PC - Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: John W. Kugler, MD    309-243-3605      
OSF St. Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: John W. Kugler, MD    309-243-3605      
Illinois Valley Community Hospital Recruiting
Peru, Illinois, United States, 61354
Contact: John W. Kugler, MD    309-243-3605      
Perry Memorial Hospital Recruiting
Princeton, Illinois, United States, 61356
Contact: John W. Kugler, MD    309-243-3605      
West Suburban Center for Cancer Care Recruiting
River Forest, Illinois, United States, 60305
Contact: Isoken Koko    708-763-2700      
Swedish-American Regional Cancer Center Recruiting
Rockford, Illinois, United States, 61104-2315
Contact: Clinical Trials Office - Swedish-American Regional Cancer Cent    815-489-4413      
Hematology Oncology Associates - Skokie Recruiting
Skokie, Illinois, United States, 60076
Contact: Al B. Benson, MD, FACP    312-695-6180      
Regional Cancer Center at Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: Clinical Trials Office - Regional Cancer Center at Memorial Me    217-788-4233      
CCOP - Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Clinical Trials Office - CCOP - Carle Cancer Center    800-446-5532      
United States, Indiana
William N. Wishard Memorial Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Elena G. Chiorean, MD    317-278-0080      
Indiana University Melvin and Bren Simon Cancer Center Recruiting
Indianapolis, Indiana, United States, 46202-5289
Contact: Clinical Trials Office - Indiana University Cancer Center    317-274-2552      
Clarian Arnett Cancer Care Recruiting
Lafayette, Indiana, United States, 47904
Contact: Thomas I. Jones, MD    765-448-7500      
Saint Anthony Memorial Health Centers Recruiting
Michigan City, Indiana, United States, 46360
Contact: Ronnie F. Luyun    219-879-8511      
United States, Iowa
McFarland Clinic, PC Recruiting
Ames, Iowa, United States, 50010
Contact: Clinical Trials Office - McFarland Clinic, PC    515-239-2621      
Cedar Rapids Oncology Associates Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Clinical Trials Office - Cedar Rapids Oncology Associates    319-363-2690      
Mercy Regional Cancer Center at Mercy Medical Center Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    319-398-6011      
Medical Oncology and Hematology Associates - West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Robert J. Behrens    515-875-9713      
Medical Oncology and Hematology Associates at Mercy Cancer Center Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-643-8740      
Mercy Cancer Center at Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-643-8206      
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-282-2921      
CCOP - Iowa Oncology Research Association Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-244-7586      
John Stoddard Cancer Center at Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Clinical Trials Office - John Stoddard Cancer Center at Iowa M    515-241-6727      
John Stoddard Cancer Center at Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Clinical Trials Office - John Stoddard Cancer Center at Iowa L    515-241-8704      
Mercy Cancer Center at Mercy Medical Center - North Iowa Recruiting
Mason City, Iowa, United States, 50401
Contact: Clinical Trials Office - Mercy Cancer Center at Mercy Medical    641-422-6304      
McCreery Cancer Center at Ottumwa Regional Recruiting
Ottumwa, Iowa, United States, 52501
Contact: Robert J. Behrens    641-684-2946      
Siouxland Hematology-Oncology Associates, LLP Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender, MD, PhD    712-252-0088      
St. Luke's Regional Medical Center Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender, MD, PhD    712-252-0088      
Mercy Medical Center - Sioux City Recruiting
Sioux City, Iowa, United States, 51102
Contact: Donald B. Wender, MD, PhD    712-252-0088      
United States, Kansas
Cancer Center of Kansas, PA - Chanute Recruiting
Chanute, Kansas, United States, 66720
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas - Fort Scott Recruiting
Fort Scott, Kansas, United States, 66701
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas-Independence Recruiting
Independence, Kansas, United States, 67301
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Kingman Recruiting
Kingman, Kansas, United States, 67068
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Liberal Recruiting
Liberal, Kansas, United States, 67901
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - McPherson Recruiting
McPherson, Kansas, United States, 67460
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Newton Recruiting
Newton, Kansas, United States, 67114
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Parsons Recruiting
Parsons, Kansas, United States, 67357
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Pratt Recruiting
Pratt, Kansas, United States, 67124
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Salina Recruiting
Salina, Kansas, United States, 67401
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Wellington Recruiting
Wellington, Kansas, United States, 67152
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
CCOP - Wichita Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Associates in Womens Health, PA - North Review Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Via Christi Cancer Center at Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Wichita Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
Cancer Center of Kansas, PA - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil, MD, FACP    316-262-4467      
United States, Louisiana
Ochsner Health Center - Bluebonnet Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Jyotsna Fuloria    225-761-5200      
Mary Bird Perkins Cancer Center - Baton Rouge Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert W. Veith    225-767-0847      
Ochsner Health Center - Covington Recruiting
Covington, Louisiana, United States, 70433
Contact: Jyotsna Fuloria    985-875-2828      
Ochsner Cancer Institute at Ochsner Clinic Foundation Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Jyotsna Fuloria    504-842-4360      
Medical Center of Louisiana - New Orleans Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-903-2311      
MBCCOP - LSU Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-568-5151      
United States, Maryland
Greater Baltimore Medical Center Cancer Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Clinical Trials Office - Greater Baltimore Medical Center Canc    443-849-3706      
United States, Massachusetts
Baystate Regional Cancer Program at D'Amour Center for Cancer Care Recruiting
Springfield, Massachusetts, United States, 01199
Contact: Armen Asik    413-794-9338      
United States, Michigan
Hickman Cancer Center at Bixby Medical Center Recruiting
Adrian, Michigan, United States, 49221
Contact: Clinical Trials Office - Hickman Cancer Center at Bixby Medica    517-265-0116      
CCOP - Michigan Cancer Research Consortium Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip J. Stella, MD    734-712-1000      
Saint Joseph Mercy Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella, MD    734-712-1000      
Oakwood Cancer Center at Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48123-2500
Contact: Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp    313-593-8090      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute    810-762-8057      
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Hurley Medical Center    810-762-8057      
Van Elslander Cancer Center at St. John Hospital and Medical Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo    313-343-3166      
Foote Memorial Hospital Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella, MD    734-712-1000      
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord, MD    269-373-7458      
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007-3731
Contact: Clinical Trials Office - West Michigan Cancer Center    269-373-7458      
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Raymond S. Lord, MD    269-373-7458      
Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912-1811
Contact: Clinical Trials Office - Sparrow Regional Cancer Center    517-364-2890      
St. Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella, MD    734-712-1000      
Community Cancer Center of Monroe Recruiting
Monroe, Michigan, United States, 48162
Contact: Rex B. Mowat    734-242-7902      
Mercy Memorial Hospital - Monroe Recruiting
Monroe, Michigan, United States, 48162
Contact: Rex B. Mowat    734-240-8400      
St. Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella, MD    734-712-1000      
Mercy Regional Cancer Center at Mercy Hospital Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella, MD    734-712-1000      
Seton Cancer Institute at Saint Mary's - Saginaw Recruiting
Saginaw, Michigan, United States, 48601
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw    989-776-8411      
St. John Macomb Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella, MD    734-712-1000      
United States, Minnesota
MeritCare Bemidji Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen, MD    701-234-2397      
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn, MD    612-863-8585      
Mercy and Unity Cancer Center at Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn, MD    612-863-8585      
CCOP - Duluth Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel Nikcevich, MD, PhD    218-786-3625      
Miller - Dwan Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel Nikcevich, MD, PhD    218-786-3625      
Duluth Clinic Cancer Center - Duluth Recruiting
Duluth, Minnesota, United States, 55805-1983
Contact: Clinical Trials Office - Duluth Clinic Cancer Center - Duluth    218-786-3308      
Fairview Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Clinical Trials Office - Fairview Southdale Hospital    612-625-3650      
Mercy and Unity Cancer Center at Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick J. Flynn, MD    612-863-8585      
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Patrick J. Flynn, MD    612-863-8585      
HealthEast Cancer Care at St. John's Hospital Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-863-8585      
Minnesota Oncology - Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-863-8585      
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Clinical Trials Office - Virginia Piper Cancer Institute    612-863-5654      
Hennepin County Medical Center - Minneapolis Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Clinical Trials Office - Hennepin County Medical Center - Minn    612-873-5911      
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Patrick J. Flynn, MD    612-863-8585      
Humphrey Cancer Center at North Memorial Outpatient Center Recruiting
Robbinsdale, Minnesota, United States, 55422-2900
Contact: Clinical Trials Office - Humphrey Cancer Center at North Memor    763-520-1893      
Park Nicollet Cancer Center Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-863-8585      
CCOP - Metro-Minnesota Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-863-8585      
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn, MD    612-863-8585      
St. Francis Cancer Center at St. Francis Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn, MD    612-863-8585      
Regions Hospital Cancer Care Center Recruiting
St. Paul, Minnesota, United States, 55101
Contact: Clinical Trials Office - Regions Hospital Cancer Care Center    651-254-1517      
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick J. Flynn, MD    612-863-8585      
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn, MD    612-863-8585      
Willmar Cancer Center at Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Patrick J. Flynn, MD    612-863-8585      
Minnesota Oncology - Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick J. Flynn, MD    612-863-8585      
United States, Nebraska
Cancer Resource Center - Lincoln Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
CCOP - Missouri Valley Cancer Consortium Recruiting
Omaha, Nebraska, United States, 68106
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Gamini S. Soori, MD, FACP, FRCP, MBA    402-393-3110      
Alegant Health Cancer Center at Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Clinical Trials Office - Alegant Health Cancer Center at Berge    402-398-6060      
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131-2197
Contact: Clinical Trials Office - Creighton University Medical Center    402-280-4100      
United States, New Jersey
Veterans Affairs Medical Center - East Orange Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Basil S. Kasimis, MD, DSc    973-395-7809      
Hunterdon Regional Cancer Center at Hunterdon Medical Center Recruiting
Flemington, New Jersey, United States, 08822
Contact: Kenneth B. Blankstein, MD    908-788-6100      
CentraState Medical Center Recruiting
Freehold, New Jersey, United States, 07728
Contact: Jeffrey M. Silberberg, MD    732-431-8400      
United States, New Mexico
Hematology Oncology Associates, PC Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Fa-Chyi Lee, MD    505-272-4175      
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital Recruiting
Albuquerque, New Mexico, United States, 87110
Contact: Fa-Chyi Lee, MD    505-272-4175      
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87131-5636
Contact: Clinical Trials Office - University of New Mexico Cancer Cente    505-272-6972      
New Mexico Cancer Care Associates Recruiting
Santa Fe, New Mexico, United States, 87505
Contact: Clinical Trials Office - New Mexico Cancer Care Associates    505-955-7910      
United States, New York
NYU Cancer Institute at New York University Medical Center Recruiting
New York, New York, United States, 10016
Contact: Deirdre J. Cohen    212-263-6485      
United States, North Dakota
CCOP - MeritCare Hospital Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen, MD    701-234-2397      
Roger Maris Cancer Center at MeritCare Hospital Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen, MD    701-234-2397      
United States, Ohio
Summa Center for Cancer Care at Akron City Hospital Recruiting
Akron, Ohio, United States, 44309-2090
Contact: Clinical Trials Office - Akron City Hospital    330-375-6101      
Wood County Oncology Center Recruiting
Bowling Green, Ohio, United States, 43402
Contact: Rex B. Mowat    419-352-9498      
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: Clinical Trials Office - Adena Regional Medical Center    877-779-7585      
MetroHealth Cancer Care Center at MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook, MD, FACS    216-778-4795      
Case Comprehensive Cancer Center Recruiting
Cleveland, Ohio, United States, 44106-5065
Contact: Clinical Trials Office - Case Comprehensive Cancer Center    800-641-2422      
Doctors Hospital at Ohio Health Recruiting
Columbus, Ohio, United States, 43228
Contact: Clinical Trials Office - Doctors Hospital at Ohio Health    614-566-3275      
Mount Carmel Health - West Hospital Recruiting
Columbus, Ohio, United States, 43222
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
CCOP - Columbus Recruiting
Columbus, Ohio, United States, 43215
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Grant Medical Center Cancer Care Recruiting
Columbus, Ohio, United States, 43215
Contact: Clinical Trials Office - Grant Medical Center Cancer Care    614-566-4475      
Riverside Methodist Hospital Cancer Care Recruiting
Columbus, Ohio, United States, 43214-3998
Contact: Clinical Trials Office - Riverside Methodist Hospital Cancer C    614-566-4475      
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Hematology Oncology Center Recruiting
Elyria, Ohio, United States, 44035
Contact: Rex B. Mowat    440-324-0401      
Community Cancer Center Recruiting
Elyria, Ohio, United States, 44035
Contact: Rex B. Mowat    440-324-0400      
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
St. Rita's Medical Center Recruiting
Lima, Ohio, United States, 45801
Contact: Clinical Trials Office - St. Rita's Medical Center    419-226-9617      
Lima Memorial Hospital Recruiting
Lima, Ohio, United States, 45804
Contact: Rex B. Mowat    419-228-3335      
Strecker Cancer Center at Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Northwest Ohio Oncology Center Recruiting
Maumee, Ohio, United States, 43537-1839
Contact: Rex B. Mowat    419-891-5600      
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Licking Memorial Cancer Care Program at Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Toledo Clinic - Oregon Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    419-691-4235      
St. Charles Mercy Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    419-696-7200      
North Coast Cancer Care, Incorporated Recruiting
Sandusky, Ohio, United States, 44870
Contact: Rex B. Mowat    419-626-9090      
Community Hospital of Springfield and Clark County Recruiting
Springfield, Ohio, United States, 45505
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Flower Hospital Cancer Center Recruiting
Sylvania, Ohio, United States, 43560
Contact: Clinical Trials Office - Flower Hospital Cancer Center    419-824-1842      
Mercy Hospital of Tiffin Recruiting
Tiffin, Ohio, United States, 44883
Contact: Rex B. Mowat    419-447-3130      
Toledo Clinic, Incorporated - Main Clinic Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    419-479-5605      
CCOP - Toledo Community Hospital Recruiting
Toledo, Ohio, United States, 43617
Contact: Rex B. Mowat    419-843-6147      
St. Vincent Mercy Medical Center Recruiting
Toledo, Ohio, United States, 43608
Contact: Rex B. Mowat    419-251-4515      
Toledo Hospital Recruiting
Toledo, Ohio, United States, 43606
Contact: Clinical Trials Office - Toledo Hospital    419-824-1842      
Medical University of Ohio Cancer Center Recruiting
Toledo, Ohio, United States, 43614
Contact: Clinical Trials Office - Medical University of Ohio Cancer Cen    419-383-6583      
St. Anne Mercy Hospital Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    419-407-2663      
Fulton County Health Center Recruiting
Wauseon, Ohio, United States, 43567
Contact: Clinical Trials Office - Fulton County Health Center    419-330-2708      
Mount Carmel St. Ann's Cancer Center Recruiting
Westerville, Ohio, United States, 43081
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Genesis - Good Samaritan Hospital Recruiting
Zanesville, Ohio, United States, 43701
Contact: Clinical Trials Office - Genesis - Good Samaritan Hospital    740-454-5232      
United States, Oklahoma
Natalie Warren Bryant Cancer Center at St. Francis Hospital Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Joseph P. Lynch, MD    918-494-8275      
United States, Pennsylvania
St. Luke's Cancer Network at St. Luke's Hospital Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Sanjiv S. Agarwala, MD    610-954-2145      
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Clinical Trials Office - Bryn Mawr Hospital    610-645-2680      
Geisinger Cancer Institute at Geisinger Health Recruiting
Danville, Pennsylvania, United States, 17822-0001
Contact: Clinical Trials Office - Geisinger Cancer Institute    570-271-5251      
Doylestown Hospital Cancer Center Recruiting
Doylestown, Pennsylvania, United States, 18901
Contact: Mitchell Alden, DO    215-345-8444      
PinnacleHealth Regional Cancer Center at Polyclinic Hospital Recruiting
Harrisburg, Pennsylvania, United States, 17110-2098
Contact: Oncology Clinical Trial Coordinator    717-782-4750      
Geisinger Hazleton Cancer Center Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Maged F. Khalil    570-459-2901      
Cancer Center of Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301-1792
Contact: Clinical Trials Office - Cancer Center of Paoli Memorial Hospi    610-648-1637      
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19107-5541
Contact: Clinical Trials Office - Kimmel Cancer Center at Thomas Jeffer    215-955-6084      
Joan Karnell Cancer Center at Pennsylvania Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Bernard A. Mason, MD    215-829-6088      
Abramson Cancer Center of the University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104-4283
Contact: Clinical Trials Office - Abramson Cancer Center of the Univers    800-474-9892      
Fox Chase Cancer Center - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19111-2497
Contact: Clinical Trials Office - Fox Chase Cancer Center - Philadelphi    215-728-4790      
Pottstown Memorial Regional Cancer Center Recruiting
Pottstown, Pennsylvania, United States, 19464
Contact: Wei Song, MD, PhD    610-327-7555      
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center Recruiting
Reading, Pennsylvania, United States, 19612-6052
Contact: Clinical Trials Office - McGlinn Family Regional Cancer Center    610-988-9323      
Hematology and Oncology Associates of Northeastern Pennsylvania Recruiting
Scranton, Pennsylvania, United States, 18508
Contact: Edith P. Mitchell, MD, FACP    215-955-8874      
Grand View Hospital Recruiting
Sellersville, Pennsylvania, United States, 18960
Contact: Anthony J. Magdalinski, III    215-453-4000      
Geisinger Medical Group - Scenery Park Recruiting
State College, Pennsylvania, United States, 16801
Contact: Maged F. Khalil    814-231-4560      
Chester County Hospital Recruiting
West Chester, Pennsylvania, United States, 19380
Contact: Clinical Trials Office - Chester County Hospital    610-431-5297      
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Clinical Trials Office - Frank M. and Dorothea Henry Cancer Ce    570-271-5251      
Lankenau Cancer Center at Lankenau Hospital Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Paul B. Gilman, MD    610-645-2000      
CCOP - Main Line Health Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Paul B. Gilman, MD    610-645-2000      
United States, South Dakota
Sanford Cancer Center at Sanford USD Medical Center Recruiting
Sioux Falls, South Dakota, United States, 57117-5039
Contact: Clinical Trials Office - Sanford Cancer Center    605-328-1367      
United States, Texas
Parkland Memorial Hospital Recruiting
Dallas, Texas, United States, 75235
Contact: Udit Verma    214-590-5582      
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Clinical Trials Office - Simmons Comprehensive Cancer Center a    866-460-4673; 214-648-7097      
CCOP - Scott and White Hospital Recruiting
Temple, Texas, United States, 76508
Contact: Lucas Wong, MD    254-724-1053      
United States, Virginia
Fredericksburg Oncology, Incorporated Recruiting
Fredericksburg, Virginia, United States, 22401
Contact: Rex B. Mowat    540-368-0500      
United States, West Virginia
West Virginia University Health Sciences Center - Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer, MD    304-388-8380      
United States, Wisconsin
Langlade Memorial Hospital Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Hamied R. Rezazadeh, MD    715-847-2121      
Marshfield Clinic Cancer Care at Regional Cancer Center Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Elena N. Theodosiou    715-387-5426      
St. Vincent Hospital Regional Cancer Center Recruiting
Green Bay, Wisconsin, United States, 54307-3508
Contact: Clinical Trials Office - St. Vincent Hospital Regional Cancer    920-433-8889      
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Clinical Trials Office - Vince Lombardi Cancer Clinic - Green    414-649-5717      
UW Cancer Center Johnson Creek Recruiting
Johnson Creek, Wisconsin, United States, 53038
Contact: Sam J. Lubner    920-699-3500      
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792-6164
Contact: Clinical Trials Office - University of Wisconsin Paul P. Carbo    608-262-5223      
Holy Family Memorial Medical Center Cancer Care Center Recruiting
Manitowoc, Wisconsin, United States, 54221-1450
Contact: Clinical Trials Office - Holy Family Memorial Medical Center C    920-320-2749      
Vince Lombardi Cancer Clinic - Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Dhimant R. Patel, MD    920-288-4180      
Bay Area Cancer Care Center at Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Gerald K. Bayer, MD    920-432-6049      
Marshfield Clinic - Marshfield Center Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Clinical Trials Office - Marshfield Clinic - Marshfield Center    800-782-1581 ext. 94457      
Marshfield Clinic - Lakeland Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Elena N. Theodosiou    715-358-1000      
Regional Cancer Center at Oconomowoc Memorial Hospital Recruiting
Oconomowoc, Wisconsin, United States, 53066
Contact: Clinical Trials Office - Regional Cancer Center at Oconomowoc    262-928-7878      
Ministry Medical Group at Saint Mary's Hospital Recruiting
Rhinelander, Wisconsin, United States, 54501
Contact: Elena N. Theodosiou    715-361-4700      
Marshfield Clinic - Indianhead Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Elena N. Theodosiou    715-236-8100      
St. Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Gerald K. Bayer, MD    920-432-6049      
Vince Lombardi Cancer Clinic - Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Clinical Trials Office - Vince Lombardi Cancer Clinic - Sheboy    414-649-7200      
Marshfield Clinic at Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Elena N. Theodosiou    715-295-1900      
Aurora Medical Center Recruiting
Summit, Wisconsin, United States, 53066
Contact: Dhimant R. Patel, MD    920-288-4180      
Vince Lombardi Cancer Clinic - Two Rivers Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Dhimant R. Patel, MD    920-288-4180      
Waukesha Memorial Hospital Regional Cancer Center Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Clinical Trials Office - Waukesha Memorial Hospital Regional C    262-928-7632      
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Clinical Trials Office - University of Wisconsin Cancer Center    608-262-5223      
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Elena N. Theodosiou    715-393-3900      
Marshfield Clinic - Weston Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Elena N. Theodosiou    715-393-1000      
Riverview UW Cancer Center at Riverview Hospital Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Ron J. Kirschling, MD, FACP    715-421-7442      
Marshfield Clinic - Wisconsin Rapids Center Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Elena N. Theodosiou    715-424-8600      
Sponsors and Collaborators
Pam Cogliano
Investigators
Principal Investigator: Howard S. Hochster, MD New York University School of Medicine
  More Information

Additional Information:
No publications provided

Responsible Party: Pam Cogliano, Protocol Development Manager, Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier: NCT01079780     History of Changes
Other Study ID Numbers: CDR0000666736, ECOG-E7208
Study First Received: March 2, 2010
Last Updated: September 19, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Eastern Cooperative Oncology Group:
mucinous adenocarcinoma of the colon
recurrent colon cancer
signet ring adenocarcinoma of the colon
stage III colon cancer
stage IV colon cancer
mucinous adenocarcinoma of the rectum
recurrent rectal cancer
signet ring adenocarcinoma of the rectum
stage III rectal cancer
stage IV rectal cancer

Additional relevant MeSH terms:
Colorectal Neoplasms
Colonic Diseases
Digestive System Diseases
Digestive System Neoplasms
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Intestinal Diseases
Intestinal Neoplasms
Neoplasms
Neoplasms by Site
Rectal Diseases
Bevacizumab
Camptothecin
Cetuximab
Irinotecan
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Enzyme Inhibitors
Growth Inhibitors
Growth Substances
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Radiation-Sensitizing Agents
Therapeutic Uses
Topoisomerase I Inhibitors
Topoisomerase Inhibitors

ClinicalTrials.gov processed this record on October 30, 2014