This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure (PARADIGM-HF)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
NCT01035255
First received: December 16, 2009
Last updated: October 10, 2014
Last verified: October 2014
  Purpose

The study will evaluate the efficacy and safety of LCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV and EF =< 35%).


Condition Intervention Phase
Heart Failure With Reduced Ejection Fraction
Drug: LCZ696 200 mg BID
Drug: Enalapril 10 mg BID
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Patients With Chronic Heart Failure and Reduced Ejection Fraction

Resource links provided by NLM:


Further study details as provided by Novartis:

Primary Outcome Measures:
  • Time to first occurrence of the composite endpoint, which is defined as either CV death or HF hospitalization [ Time Frame: up to 4yrs ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Change in the clinical summary score for HF symptoms and physical limitations (as assessed by KCCQ). [ Time Frame: up to 4yrs ] [ Designated as safety issue: No ]
  • Time to all-cause mortality [ Time Frame: up to 4yrs ] [ Designated as safety issue: Yes ]
  • Time to occurrence of renal dysfunction [ Time Frame: up to 4yrs ] [ Designated as safety issue: No ]

Enrollment: 8456
Study Start Date: December 2009
Study Completion Date: May 2014
Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: LCZ696 200 mg BID
LCZ696 200mg BID
Drug: LCZ696 200 mg BID
LCZ696 200 mg BID
Active Comparator: Enalapril 10 mg BID
Enalapril 10 mg BID
Drug: Enalapril 10 mg BID
Enalapril 10 mg BID

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must give written informed consent before any assessment is performed.
  • Outpatients ≥ 18 years of age, male or female.
  • Patients with a diagnosis of CHF NYHA class II-IV and reduced ejection fraction (EF =< 35%) and elevated BNP.
  • Patients must be on an ACEI or an ARB at a stable dose of at least enalapril 10 mg/d or equivalent for at least 4 weeks.
  • Patients must be treated with a β-blocker, unless contraindicated or not tolerated, at a stable dose for at least 4 weeks.

Exclusion Criteria:

  • Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer.
  • History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACEIs, ARBs, or NEP inhibitors as well as known or suspected contraindications to the study drugs.
  • Previous history of intolerance to recommended target doses of ACEIs or ARBs
  • Known history of angioedema.
  • Requirement of treatment with both ACEIs and ARBs.
  • Current acute decompensated HF (exacerbation of chronic HF manifested by signs and symptoms that may require intravenous therapy).
  • Symptomatic hypotension and/or a SBP < 100 mmHg.
  • Estimated GFR < 30 mL/min/1.73m2 as measured by the simplified MDRD formula
  • Serum potassium > 5.2 mmol/L.

Other protocol-defined inclusion/exclusion criteria may apply.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01035255

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San Miguel, Santiago, Chile, 8900000
Novartis Investigative Site
Vitacura, Santiago, Chile, 7630000
Novartis Investigative Site
Santiago, Chile
Novartis Investigative Site
Talcahuano, Chile
China, Beijing
Novartis Investigative Site
Beijing, Beijing, China, 100037
China, Heilongjiang
Novartis Investigative Site
Harbin, Heilongjiang, China, 150001
China, Hunan
Novartis Investigative Site
Changsha, Hunan, China, 410003
China, Jiangsu
Novartis Investigative Site
Nanjing, Jiangsu, China
Novartis Investigative Site
Nanjing, Jiangsu, China, 210029
Novartis Investigative Site
Nanjing, Jiangsu, China, 210009
China, Liaoning
Novartis Investigative Site
Shenyang, Liaoning, China, 110003
China, Shanxi
Novartis Investigative Site
Xi'an, Shanxi, China, 710061
China, Sichuan
Novartis Investigative Site
Chengdu, Sichuan, China, 610041
China, Zhejiang
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310009
China
Novartis Investigative Site
Baotou, China, 014040
Novartis Investigative Site
Beijing, China, 100730
Novartis Investigative Site
Beijing, China, 100044
Novartis Investigative Site
Beijing, China, 100029
Novartis Investigative Site
Chongqing, China, 400037
Novartis Investigative Site
Shanghai, China, 200080
Colombia
Novartis Investigative Site
Barranquilla, Atlantico, Colombia
Novartis Investigative Site
Cartagena, Bolivar, Colombia
Novartis Investigative Site
Bogota, Cundinamarca, Colombia, 0000
Novartis Investigative Site
Bucaramanga, Santander, Colombia
Novartis Investigative Site
Floridablanca, Santander, Colombia, 57-7
Novartis Investigative Site
Barranquilla, Colombia
Novartis Investigative Site
Bogotá, Colombia
Novartis Investigative Site
Cali, Colombia
Novartis Investigative Site
Cartegena, Colombia
Novartis Investigative Site
Florida Blanca, Colombia
Novartis Investigative Site
Medellín, Colombia
Czech Republic
Novartis Investigative Site
Bilovec, CZE, Czech Republic, 743 01
Novartis Investigative Site
Praha 2, CZE, Czech Republic, 128 08
Novartis Investigative Site
Beroun, Czech Republic, 266 01
Novartis Investigative Site
Brandys nad Labem, Czech Republic, 250 01
Novartis Investigative Site
Horovice, Czech Republic, 268 01
Novartis Investigative Site
Jablonec nad Nisou, Czech Republic, 466 01
Novartis Investigative Site
Karlovy Vary, Czech Republic, 360 09
Novartis Investigative Site
Kladno, Czech Republic, 272 01
Novartis Investigative Site
Klatovy, Czech Republic, 339 01
Novartis Investigative Site
Kolin, Czech Republic, 280 20
Novartis Investigative Site
Liberec 1, Czech Republic, 460 63
Novartis Investigative Site
Melnik, Czech Republic, 276 01
Novartis Investigative Site
Olomouc, Czech Republic, 779 00
Novartis Investigative Site
Plzen, Czech Republic, 301 00
Novartis Investigative Site
Prague 1, Czech Republic, 110 00
Novartis Investigative Site
Prague 10, Vrsovice, Czech Republic, 10100
Novartis Investigative Site
Prague 5, Czech Republic, 150 30
Novartis Investigative Site
Praha 2, Czech Republic, 128 08
Novartis Investigative Site
Praha 4, Czech Republic, 142 00
Novartis Investigative Site
Semily, Czech Republic, 513 31
Novartis Investigative Site
Strakonice, Czech Republic, 38601
Novartis Investigative Site
Trebic, Czech Republic, 674 01
Novartis Investigative Site
Uherske Hradiste, Czech Republic, 686 01
Novartis Investigative Site
Uherske Hradiste, Czech Republic, 68601
Novartis Investigative Site
Usti nad Labem, Czech Republic, 400 01
Denmark
Novartis Investigative Site
Aarhus C, Denmark, DK-8000
Novartis Investigative Site
Copenhagen, Denmark, DK-2100
Novartis Investigative Site
Esbjerg, Denmark, DK-6700
Novartis Investigative Site
Hellerup, Denmark, DK-2900
Novartis Investigative Site
Herning, Denmark, DK-7400
Novartis Investigative Site
Randers NØ, Denmark, DK-8930
Novartis Investigative Site
Roskilde, Denmark, DK-4000
Novartis Investigative Site
Svendborg, Denmark, DK-5700
Novartis Investigative Site
Vejle, Denmark, DK-7100
Novartis Investigative Site
Viborg, Denmark, DK-8800
Dominican Republic
Novartis Investigative Site
Santo Domingo, Republica Dominicana, Dominican Republic
Novartis Investigative Site
Santo Domingo, Dominican Republic
Ecuador
Novartis Investigative Site
Guayaquil, Guayas, Ecuador, 559
Novartis Investigative Site
Guayaquil, Guayas, Ecuador, 412
Novartis Investigative Site
Guayaquil, Guayas, Ecuador
Novartis Investigative Site
Quito, Pichincha, Ecuador, 1701
Estonia
Novartis Investigative Site
Haabneeme, Viimsi vald, Estonia, 74001
Novartis Investigative Site
Tallinn, Estonia, 13419
Novartis Investigative Site
Tallinn, Estonia, 10138
Novartis Investigative Site
Tartu, Estonia, 50410
Finland
Novartis Investigative Site
HUS, Finland, 00029
Novartis Investigative Site
Kemi, Finland, FIN-94100
Novartis Investigative Site
Kuopio, Finland, 70100
Novartis Investigative Site
Oulu, Finland, 90100
Novartis Investigative Site
Tampere, Finland, 33521
France
Novartis Investigative Site
Strasbourg, Cedex, France, 67091
Novartis Investigative Site
Abbeville, France, 80100
Novartis Investigative Site
Bayonne, France, 64100
Novartis Investigative Site
Bayonne, France, 64109
Novartis Investigative Site
Beziers Cedex, France, 34525
Novartis Investigative Site
Bordeaux Cedex, France, 33075
Novartis Investigative Site
Caen, France, 14000
Novartis Investigative Site
Cholet, France, 49325
Novartis Investigative Site
Creteil, France, 94010
Novartis Investigative Site
Essey Les Nancy, France, 54270
Novartis Investigative Site
Grenoble, France, 38043
Novartis Investigative Site
Lagny sur Marne, France, 77405
Novartis Investigative Site
Langres, France, 52206
Novartis Investigative Site
Le Chesnay, France
Novartis Investigative Site
Le Plessis Robinson, France, 92350
Novartis Investigative Site
Limoges, France, 87001
Novartis Investigative Site
Lomme, France, 59462
Novartis Investigative Site
Montpellier, France, 34195
Novartis Investigative Site
Nice Cedex 1, France, 06602
Novartis Investigative Site
Paris, France, 75015
Novartis Investigative Site
Paris cedex 10, France, 75475
Novartis Investigative Site
Reims, France, 51092
Novartis Investigative Site
Rouen, France, 76031
Novartis Investigative Site
St Aubin Lès Elbeuf, France, 76410
Novartis Investigative Site
Toulouse Cedex, France, 31059
Novartis Investigative Site
Tourcoing, France, 59208
Novartis Investigative Site
Valencienne, France, 59322
Novartis Investigative Site
Vandoeuvre les Nancy, France, 54511
Germany
Novartis Investigative Site
Mannheim, Baden-Württemberg, Germany, 68305
Novartis Investigative Site
Ahrensfelde, Germany, 16356
Novartis Investigative Site
Anderbeck, Germany, 38836
Novartis Investigative Site
Bad Homburg, Germany, 61348
Novartis Investigative Site
Bad Krozingen, Germany, 79189
Novartis Investigative Site
Bad Salzuflen, Germany, 32105
Novartis Investigative Site
Bad Schwartau, Germany, 23611
Novartis Investigative Site
Barsinghausen, Germany, 30890
Novartis Investigative Site
Berlin, Germany, 10787
Novartis Investigative Site
Berlin, Germany, 10559
Novartis Investigative Site
Berlin, Germany, 10115
Novartis Investigative Site
Berlin, Germany, 13055
Novartis Investigative Site
Berlin, Germany, 10117
Novartis Investigative Site
Berlin, Germany, 10369
Novartis Investigative Site
Berlin, Germany, 13347
Novartis Investigative Site
Berlin, Germany, 14050
Novartis Investigative Site
Berlin, Germany, 10789
Novartis Investigative Site
Berlin, Germany, 13509
Novartis Investigative Site
Berlin-Buch, Germany, 13125
Novartis Investigative Site
Bernau, Germany, 16321
Novartis Investigative Site
Bitburg, Germany, 54634
Novartis Investigative Site
Bremen, Germany, 28277
Novartis Investigative Site
Chemnitz, Germany, 09130
Novartis Investigative Site
Darmstadt, Germany, 64287
Novartis Investigative Site
Dessau-Roßlau, Germany, 06846
Novartis Investigative Site
Dietzenbach, Germany, 63128
Novartis Investigative Site
Dortmund, Germany, 44137
Novartis Investigative Site
Dresden, Germany, 01309
Novartis Investigative Site
Dresden, Germany, 01129
Novartis Investigative Site
Dresden, Germany, 01127
Novartis Investigative Site
Dresden, Germany, 01099
Novartis Investigative Site
Eilenburg, Germany, 04838
Novartis Investigative Site
Elsterwerda, Germany, 04910
Novartis Investigative Site
Erfurt, Germany, 99084
Novartis Investigative Site
Frankfurt, Germany, 65929
Novartis Investigative Site
Frankfurt, Germany, 60488
Novartis Investigative Site
Georgsmarienhütte, Germany, 49124
Novartis Investigative Site
Giengen, Germany, 89537
Novartis Investigative Site
Goch, Germany, 47574
Novartis Investigative Site
Graben-Neudorf, Germany, 76676
Novartis Investigative Site
Hamburg, Germany, 22527
Novartis Investigative Site
Hamburg, Germany, 22041
Novartis Investigative Site
Hamburg, Germany, 22291
Novartis Investigative Site
Hamburg, Germany, 22765
Novartis Investigative Site
Hamburg, Germany, 21075
Novartis Investigative Site
Hamminkeln, Germany, 46499
Novartis Investigative Site
Hannover, Germany, 30165
Novartis Investigative Site
Heidelberg, Germany, 69115
Novartis Investigative Site
Homburg, Germany, 66421
Novartis Investigative Site
Hoppegarten-Dahlwitz, Germany, 15366
Novartis Investigative Site
Ingelheim, Germany, 55218
Novartis Investigative Site
Jena, Germany, 07740
Novartis Investigative Site
Jena, Germany, 07743
Novartis Investigative Site
Kallstadt, Germany, 67169
Novartis Investigative Site
Kassel, Germany, 34125
Novartis Investigative Site
Kassel, Germany, 34127
Novartis Investigative Site
Kassel, Germany, 34121
Novartis Investigative Site
Kelkheim, Germany, 65779
Novartis Investigative Site
Koethen, Germany, 06366
Novartis Investigative Site
Künzelsau, Germany, 74653
Novartis Investigative Site
Langen, Germany, 63225
Novartis Investigative Site
Leipzig, Germany, 04315
Novartis Investigative Site
Leipzig, Germany, 04103
Novartis Investigative Site
Leipzig, Germany, 04357
Novartis Investigative Site
Leipzig, Germany, 04109
Novartis Investigative Site
Leipzig, Germany, 04129
Novartis Investigative Site
Loehne, Germany, 32584
Novartis Investigative Site
Ludwigshafen, Germany, 67067
Novartis Investigative Site
Ludwigshafen, Germany, 67061
Novartis Investigative Site
Lübeck, Germany, 23558
Novartis Investigative Site
Lütjenburg, Germany, 24321
Novartis Investigative Site
Mainz, Germany, 55131
Novartis Investigative Site
Mainz, Germany, 55116
Novartis Investigative Site
Mannheim, Germany, 68165
Novartis Investigative Site
Meissen, Germany, 01662
Novartis Investigative Site
Meißen, Germany, 01663
Novartis Investigative Site
Muenster, Germany, 48149
Novartis Investigative Site
Mönchengladbach, Germany, 41063
Novartis Investigative Site
Mühldorf, Germany, 84453
Novartis Investigative Site
Mühlheim, Germany, 45468
Novartis Investigative Site
München, Germany, 80336
Novartis Investigative Site
Münster, Germany, 48149
Novartis Investigative Site
Neunkirchen, Germany, 66539
Novartis Investigative Site
Neunkirchen, Germany, 57290
Novartis Investigative Site
Nienburg, Germany, 31582
Novartis Investigative Site
Offenbach, Germany, 63073
Novartis Investigative Site
Oldenburg i.H., Germany, 23758
Novartis Investigative Site
Osnabrück, Germany, 49080
Novartis Investigative Site
Papenburg, Germany, 26871
Novartis Investigative Site
Rhaunen, Germany, 55624
Novartis Investigative Site
Riesa, Germany, 01589
Novartis Investigative Site
Rodgau, Germany, 63110
Novartis Investigative Site
Schenklengsfeld, Germany, 36277
Novartis Investigative Site
Schkeuditz, Germany, 04435
Novartis Investigative Site
Schwäbisch Hall, Germany, 74523
Novartis Investigative Site
St. Ingbert - Oberwuerzbach, Germany, 66386
Novartis Investigative Site
Unterschneidheim, Germany, 73485
Novartis Investigative Site
Wangen, Germany, 88239
Novartis Investigative Site
Wardenburg, Germany, 26203
Novartis Investigative Site
Weeze, Germany, 47652
Novartis Investigative Site
Wermsdorf, Germany, 04779
Novartis Investigative Site
Westhofen, Germany, 67593
Novartis Investigative Site
Wetzlar-Naunheim, Germany, 35584
Novartis Investigative Site
Weyhe, Germany, 28844
Novartis Investigative Site
Wolmirstedt, Germany, 39326
Guatemala
Novartis Investigative Site
Guatemala City, Guatemala, 01015
Novartis Investigative Site
Guatemala City, Guatemala, 01010
Novartis Investigative Site
Guatemala City, Guatemala, 01011
Hong Kong
Novartis Investigative Site
Hong Kong, Hong Kong
Novartis Investigative Site
Hong Kong, Hong Kong, Hong Kong
Novartis Investigative Site
Hong Kong SAR, Hong Kong
Hungary
Novartis Investigative Site
Pecs, Baranya, Hungary, 7621
Novartis Investigative Site
Baja, Hungary, 6500
Novartis Investigative Site
Balatonfured, Hungary, H-8231
Novartis Investigative Site
Budapest, Hungary, H-1032
Novartis Investigative Site
Budapest, Hungary, H-1106
Novartis Investigative Site
Budapest, Hungary, 1021
Novartis Investigative Site
Budapest, Hungary, 1096
Novartis Investigative Site
Budapest, Hungary, 1125
Novartis Investigative Site
Budapest, Hungary, 1085
Novartis Investigative Site
Budapest, Hungary, 1043
Novartis Investigative Site
Budapest, Hungary, 1134
Novartis Investigative Site
Budapest, Hungary, 1145
Novartis Investigative Site
Budapest, Hungary, H-1096
Novartis Investigative Site
Budapest, Hungary, 1122
Novartis Investigative Site
Budapest, Hungary, 1027
Novartis Investigative Site
Cegled, Hungary, 2700
Novartis Investigative Site
Debrecen, Hungary, 4032
Novartis Investigative Site
Eger, Hungary, H-3300
Novartis Investigative Site
Hodmezovasarhely, Hungary, 6800
Novartis Investigative Site
Kaposvár, Hungary, 7400
Novartis Investigative Site
Miskolc, Hungary, 3526
Novartis Investigative Site
Nagykanizsa, Hungary, 8800
Novartis Investigative Site
Nyiregyháza, Hungary, 4400
Novartis Investigative Site
Pecs, Hungary, 7643
Novartis Investigative Site
Sopron, Hungary, 9400
Novartis Investigative Site
Szeged, Hungary, H-6720
Novartis Investigative Site
Szekesfehervar, Hungary, 8000
Novartis Investigative Site
Szekszard, Hungary, 7100
Novartis Investigative Site
Zalaegerszeg, Hungary, 8900
Iceland
Novartis Investigative Site
Kopavogur, Iceland, 201
Novartis Investigative Site
Reykjavik, Iceland, IS-101
Novartis Investigative Site
Reykjavik, Iceland, IS-109
India
Novartis Investigative Site
Hyderabad, Andhra Pradesh, INDIA, India, 500034
Novartis Investigative Site
Guntur, Andhra Pradesh, India, 522001
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India, 500082
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India, 500012
Novartis Investigative Site
Tirupati, Andhra Pradesh, India, 517501
Novartis Investigative Site
Vishakhapatnam, Andhra Pradesh, India, 530 013
Novartis Investigative Site
Vishakhapatnam, Andhra Pradesh, India, 530002
Novartis Investigative Site
Dehli, Delhi, India, 110080
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380014
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380 013
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380025
Novartis Investigative Site
Anand, Gujarat, India, 388325
Novartis Investigative Site
Surat, Gujarat, India, 395007
Novartis Investigative Site
Surat, Gujarat, India, 395001
Novartis Investigative Site
Rajkot, Gujrat, India, 360001
Novartis Investigative Site
Vadodara, Gujrat, India, 390015
Novartis Investigative Site
Gurgaon, Haryana, India, 122001
Novartis Investigative Site
Bangalore, Karnataka, India, 560038
Novartis Investigative Site
Bangalore, Karnataka, India, 560092
Novartis Investigative Site
Banglaore, Karnataka, India, 560054
Novartis Investigative Site
Mangalore, Karnataka, India, 575002
Novartis Investigative Site
Mysore, Karnataka, India, 570004
Novartis Investigative Site
Cochin, Kerala, India, 683572
Novartis Investigative Site
Trivandrum, Kerala, India, 695011
Novartis Investigative Site
Trivandrum, Kerala, India, 695607
Novartis Investigative Site
Mumbai, Maharashtra, India, 400012
Novartis Investigative Site
Nagpur, Maharashtra, India, 44000033
Novartis Investigative Site
Nagpur, Maharashtra, India, 440 010
Novartis Investigative Site
Nagpur, Maharashtra, India, 400012
Novartis Investigative Site
Nashik, Maharashtra, India, 422 005
Novartis Investigative Site
Nashik, Maharashtra, India, 422002
Novartis Investigative Site
Nashik, Maharashtra, India, 422005
Novartis Investigative Site
Pune, Maharashtra, India, 411011
Novartis Investigative Site
Pune, Maharashtra, India, 411 005
Novartis Investigative Site
Pune, Maharashtra, India, 411 011
Novartis Investigative Site
Ludhiana, Punjab, India, 141002
Novartis Investigative Site
Bikaner, Rajasthan, India, 334003
Novartis Investigative Site
Jaipur, Rajasthan, India, 302016
Novartis Investigative Site
Kota, Rajasthan, India, 324005
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600004
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600020
Novartis Investigative Site
Lucknow, Uttar Pradesh, India, 226003
Novartis Investigative Site
Varanasi, Uttar Pradesh, India, 221 005
Novartis Investigative Site
Ahmedabad, India, 380052
Novartis Investigative Site
Hyderabad, India, 500 063
Novartis Investigative Site
Indore, India, 452014
Israel
Novartis Investigative Site
Ashkelon, Israel, 78278
Novartis Investigative Site
Hadera, Israel, 38100
Novartis Investigative Site
Haifa, Israel, 31096
Novartis Investigative Site
Haifa, Israel, 34362
Novartis Investigative Site
Jerusalem, Israel, 91031
Novartis Investigative Site
Jerusalem, Israel, 91120
Novartis Investigative Site
Petach Tikva, Israel, 49100
Novartis Investigative Site
Rehovot, Israel, 76100
Novartis Investigative Site
Safed, Israel, 13100
Italy
Novartis Investigative Site
Aosta, AO, Italy, 11100
Novartis Investigative Site
Cortona, AR, Italy, 52044
Novartis Investigative Site
Bergamo, BG, Italy, 24128
Novartis Investigative Site
Seriate, BG, Italy, 24068
Novartis Investigative Site
Treviglio, BG, Italy, 24047
Novartis Investigative Site
San Pietro Vernotico, BR, Italy, 72027
Novartis Investigative Site
Bolzano, BZ, Italy, 39100
Novartis Investigative Site
Cosenza, CS, Italy, 87100
Novartis Investigative Site
Catanzaro, CZ, Italy, 88100
Novartis Investigative Site
Cona, FE, Italy, 44100
Novartis Investigative Site
Firenze, FI, Italy, 50143
Novartis Investigative Site
Genova, GE, Italy, 16132
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
Novartis Investigative Site
Lido di Camaiore, LU, Italy, 55041
Novartis Investigative Site
Monza, MB, Italy, 20900
Novartis Investigative Site
Milazzo, ME, Italy, 98057
Novartis Investigative Site
Milano, MI, Italy, 20122
Novartis Investigative Site
Modena, MO, Italy, 41100
Novartis Investigative Site
Piove di Sacco, PD, Italy, 35028
Novartis Investigative Site
Perugia, PG, Italy, 06100
Novartis Investigative Site
Pisa, PI, Italy, 56126
Novartis Investigative Site
Pescia, PT, Italy, 51017
Novartis Investigative Site
Casorate Primo, PV, Italy, 27022
Novartis Investigative Site
Pavia, PV, Italy, 27100
Novartis Investigative Site
Stradella, PV, Italy, 27049
Novartis Investigative Site
Albano Laziale, RM, Italy, 00041
Novartis Investigative Site
Roma, RM, Italy, 00163
Novartis Investigative Site
Battipaglia, SA, Italy, 84091
Novartis Investigative Site
Cava De' Tirreni, SA, Italy, 84013
Novartis Investigative Site
Salerno, SA, Italy, 84131
Novartis Investigative Site
Sassari, SS, Italy, 07100
Novartis Investigative Site
Thiesi, SS, Italy, 07047
Novartis Investigative Site
Palmanova, UD, Italy, 33057
Novartis Investigative Site
San Daniele Del Friuli, UD, Italy, 33038
Novartis Investigative Site
Tradate, VA, Italy, 21049
Novartis Investigative Site
Varese, VA, Italy, 21100
Novartis Investigative Site
Vibo Valentia, VV, Italy, 89900
Korea, Republic of
Novartis Investigative Site
Wonju, Gangwon-Do, Korea, Republic of, 220-701
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 120-752
Novartis Investigative Site
Busan, Korea, Republic of, 602-739
Novartis Investigative Site
Daegu, Korea, Republic of, 705-718
Novartis Investigative Site
Daegu, Korea, Republic of, 706-717
Novartis Investigative Site
Gwangju, Korea, Republic of, 501-575
Novartis Investigative Site
Pusan, Korea, Republic of, 614-735
Novartis Investigative Site
Seoul, Korea, Republic of, 110-102
Novartis Investigative Site
Seoul, Korea, Republic of, 137-701
Novartis Investigative Site
Seoul, Korea, Republic of, 134-701
Novartis Investigative Site
Seoul, Korea, Republic of, 738-736
Novartis Investigative Site
Seoul, Korea, Republic of, 156-707
Novartis Investigative Site
Suwon, Korea, Republic of, 442-721
Latvia
Novartis Investigative Site
Liepaja, LV, Latvia, LV-3414
Novartis Investigative Site
Daugavplis, Latvia, LV-5417
Novartis Investigative Site
Kuldiga, Latvia, LV-3300
Novartis Investigative Site
Preili, Latvia, LV-5301
Novartis Investigative Site
Riga, Latvia, 1002
Novartis Investigative Site
Ventspils, Latvia, LV-3601
Lithuania
Novartis Investigative Site
Kaunas, Lithuania, LT-49387
Novartis Investigative Site
Kaunas, Lithuania, 50009
Novartis Investigative Site
Kedainiai, Lithuania, LT-57164
Novartis Investigative Site
Siauliai, Lithuania, LT-76231
Novartis Investigative Site
Vilnius, Lithuania, LT-08661
Malaysia
Novartis Investigative Site
Pulau Pinang, Penang, Malaysia, 10990
Novartis Investigative Site
Kuching, Sarawak, Malaysia, 94300
Novartis Investigative Site
Kuala Lumpur, Malaysia, 50400
Novartis Investigative Site
Kuala Lumpur, Malaysia, 59100
Mexico
Novartis Investigative Site
Mexico, Distrito Federal, Mexico, 07300
Novartis Investigative Site
Mexico City, Distrito Federal, Mexico, 06700
Novartis Investigative Site
México, Distrito Federal, Mexico, 06720
Novartis Investigative Site
México D.F, Distrito Federal, Mexico, 03100
Novartis Investigative Site
Guadalajara, Jalisco, Mexico, 44280
Novartis Investigative Site
Zapopan, Jalisco, Mexico, 45200
Novartis Investigative Site
Monterrey, Nuevo León, Mexico, 64710
Novartis Investigative Site
San Juan del Rio, Querétaro, Mexico, 76800
Novartis Investigative Site
Aguascalientes, Mexico, 20230
Novartis Investigative Site
Querétaro, Mexico, 76000
Novartis Investigative Site
San Luis Potosi, Mexico, 78200
Novartis Investigative Site
San Luis Potosí, Mexico, 78240
Novartis Investigative Site
San Luis Potosí, Mexico, 78200
Netherlands
Novartis Investigative Site
Oss, NL, Netherlands, 5342 BT
Novartis Investigative Site
Amersfoort, Netherlands, 3813 TZ
Novartis Investigative Site
Arnhem, Netherlands, 6815 AD
Novartis Investigative Site
Blaricum, Netherlands, 1261 AN
Novartis Investigative Site
Breda, Netherlands, 4818 CK
Novartis Investigative Site
Delft, Netherlands, 2625 AD
Novartis Investigative Site
Den Bosch, Netherlands, 5223 GZ
Novartis Investigative Site
Den Haag, Netherlands, 2512 VA
Novartis Investigative Site
Ede, Netherlands, 6710 HN
Novartis Investigative Site
Eindhoven, Netherlands, 5623 EJ
Novartis Investigative Site
Goes, Netherlands, 4462 RA
Novartis Investigative Site
Gorinchem, Netherlands, 4204 AA
Novartis Investigative Site
Hardenberg, Netherlands, 7770 AA
Novartis Investigative Site
Harderwijk, Netherlands, 3840 AC
Novartis Investigative Site
Heerenveen, Netherlands, 8441 PW
Novartis Investigative Site
Hengelo, Netherlands, 7555 DL
Novartis Investigative Site
Hoorn, Netherlands, 1625 HV
Novartis Investigative Site
Maastricht, Netherlands, 6229 HX
Novartis Investigative Site
Nijmegen, Netherlands, 6525 GA
Novartis Investigative Site
Sneek, Netherlands, 8601 ZK
Novartis Investigative Site
Tilburg, Netherlands, 5022 GC
Novartis Investigative Site
Veldhoven, Netherlands, 5504 DB
Panama
Novartis Investigative Site
Panama City, Panamá, Panama, 0831-02351
Novartis Investigative Site
Panama City, Panamá, Panama
Peru
Novartis Investigative Site
Bellavista, Lima, Peru, Callao 02
Novartis Investigative Site
Cercado de Lima, Lima, Peru, 01
Novartis Investigative Site
Jesus Maria, Lima, Peru, 11
Novartis Investigative Site
La Molina, Lima, Peru, 12
Novartis Investigative Site
San Borja, Lima, Peru, 41
Novartis Investigative Site
San Isidro, Lima, Peru, 27
Novartis Investigative Site
San Miguel, Lima, Peru, 32
Novartis Investigative Site
Arequipa, Peru, Areq01
Philippines
Novartis Investigative Site
Lipa City, Batangas, Philippines, 4217
Novartis Investigative Site
Quezon City, Metro Manila, Philippines, 1109
Novartis Investigative Site
Bulacan, Philippines, 3020
Novartis Investigative Site
Manila, Philippines
Novartis Investigative Site
Manila, Philippines, 1004
Novartis Investigative Site
Manila, Philippines, 1000
Novartis Investigative Site
Pasig City, Philippines, 1605
Novartis Investigative Site
Quezon City, Philippines, 1102
Novartis Investigative Site
Quezon City, Philippines, 1100
Novartis Investigative Site
San Juan City, Philippines, 1500
Poland
Novartis Investigative Site
Bialystok, Poland, 15-875
Novartis Investigative Site
Gdynia, Poland, 81-519
Novartis Investigative Site
Gdynia, Poland, 81-548
Novartis Investigative Site
Gdynia, Poland, 81-472
Novartis Investigative Site
Gdynia, Poland, 81-157
Novartis Investigative Site
Gliwice, Poland, 44-100
Novartis Investigative Site
Golub-Dobrzyn, Poland, 87-400
Novartis Investigative Site
Katowice, Poland, 40-084
Novartis Investigative Site
Katowice, Poland, 40-645
Novartis Investigative Site
Katowice, Poland, 40-530
Novartis Investigative Site
Krakow, Poland, 30-015
Novartis Investigative Site
Krakow, Poland, 30-082
Novartis Investigative Site
Kutno, Poland, 99-300
Novartis Investigative Site
Lodz, Poland, 91-302
Novartis Investigative Site
Lublin, Poland, 20-857
Novartis Investigative Site
Olawa, Poland, 55-200
Novartis Investigative Site
Skierniewice, Poland, 96-100
Novartis Investigative Site
Wroclaw, Poland, 51-312
Novartis Investigative Site
Wroclaw, Poland, 50-088
Novartis Investigative Site
Wroclaw, Poland, 52-612
Novartis Investigative Site
Zabrze, Poland, 41-800
Portugal
Novartis Investigative Site
Vila Real, Portuigal, Portugal, 5000-508
Novartis Investigative Site
Amadora, Portugal, 2720-276
Novartis Investigative Site
Covilhã, Portugal, 6200-251
Novartis Investigative Site
Guimarães, Portugal, 4835-044
Novartis Investigative Site
Lisboa, Portugal, 1169-024
Novartis Investigative Site
Lisbon, Portugal, 1449-005
Novartis Investigative Site
Penafiel, Portugal, 4564-007
Novartis Investigative Site
Portalegre, Portugal, 7301-853
Novartis Investigative Site
Porto, Portugal, 4200-319
Novartis Investigative Site
Setúbal, Portugal, 2910-446
Romania
Novartis Investigative Site
Bucharest, District 1, Romania
Novartis Investigative Site
Bucuresti, District 1, Romania, 014461
Novartis Investigative Site
Bucuresti, District 2, Romania, 021345
Novartis Investigative Site
Bucharest, District 5, Romania, 050538
Novartis Investigative Site
Craiova, Jud. Dolj, Romania, 200147
Novartis Investigative Site
Timisoara, jud. Timis, Romania, 300359
Novartis Investigative Site
Craiova, Jud.Dolj, Romania, 200235
Novartis Investigative Site
Ploiesti, Jud.Prahova, Romania, 100410
Novartis Investigative Site
Arad, Romania, 310158
Novartis Investigative Site
Bucharest, Romania, 060011
Novartis Investigative Site
Bucharest, Romania, 050098
Novartis Investigative Site
Bucharest, Romania, 050659
Novartis Investigative Site
Bucharest, Romania, 020054
Novartis Investigative Site
Bucuresti, Romania, 062272
Novartis Investigative Site
Bucuresti, Romania, 011728
Novartis Investigative Site
Deva, Romania, 330084
Novartis Investigative Site
Pitesti, Romania, 110114
Novartis Investigative Site
Timisoara, Romania, 300361
Novartis Investigative Site
Timisoara, Romania, 300736
Novartis Investigative Site
Timisoara, Romania, 300020
Novartis Investigative Site
Timisoara, Romania, 300041
Novartis Investigative Site
Timisoara, Romania, 300310
Russian Federation
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620219
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620137
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620102
Novartis Investigative Site
Gatchina, Russian Federation, 188300
Novartis Investigative Site
Ivanovo, Russian Federation, 153012
Novartis Investigative Site
Izhevsk, Russian Federation, 426063
Novartis Investigative Site
Kazan, Russian Federation, 420012
Novartis Investigative Site
Kemerovo, Russian Federation, 650002
Novartis Investigative Site
Kemerovo, Russian Federation, 650029
Novartis Investigative Site
Kemerovo, Russian Federation, 650099
Novartis Investigative Site
Kirov, Russian Federation, 610027
Novartis Investigative Site
Krasnodar, Russian Federation, 350086
Novartis Investigative Site
Krasnodar, Russian Federation, 350012
Novartis Investigative Site
Moscow, Russian Federation, 119992
Novartis Investigative Site
Moscow, Russian Federation, 111539
Novartis Investigative Site
Moscow, Russian Federation, 109240
Novartis Investigative Site
Moscow, Russian Federation, 121309
Novartis Investigative Site
Moscow, Russian Federation, 101990
Novartis Investigative Site
Moscow, Russian Federation, 105203
Novartis Investigative Site
Moscow, Russian Federation, 119881
Novartis Investigative Site
Moscow, Russian Federation, 127473
Novartis Investigative Site
Moscow, Russian Federation, 115280
Novartis Investigative Site
Moscow, Russian Federation, 125284
Novartis Investigative Site
Moscow, Russian Federation, 105229
Novartis Investigative Site
Moscow, Russian Federation, 119333
Novartis Investigative Site
Moscow, Russian Federation, 121552
Novartis Investigative Site
Moscow, Russian Federation, 115487
Novartis Investigative Site
Moscow, Russian Federation, 115516
Novartis Investigative Site
Moscow, Russian Federation, 117198
Novartis Investigative Site
Moscow, Russian Federation, 117556
Novartis Investigative Site
N. Novgorod, Russian Federation, 603003
Novartis Investigative Site
N.Novgorod, Russian Federation, 603005
Novartis Investigative Site
N.Novgorod, Russian Federation, 603073
Novartis Investigative Site
Nizhnii Novgorod, Russian Federation, 603126
Novartis Investigative Site
Novosibirsk, Russian Federation, 630091
Novartis Investigative Site
Novosibirsk, Russian Federation, 630087
Novartis Investigative Site
Novosibirsk-117, Russian Federation, 630117
Novartis Investigative Site
Orenburg, Russian Federation, 460040
Novartis Investigative Site
Orenburg, Russian Federation, 460000
Novartis Investigative Site
Penza, Russian Federation, 440026
Novartis Investigative Site
Perm, Russian Federation, 614097
Novartis Investigative Site
Petrozavodsk, Russian Federation, 185019
Novartis Investigative Site
Rostov-on-Don, Russian Federation, 344718
Novartis Investigative Site
S-Petersburg, Russian Federation, 191144
Novartis Investigative Site
S.-Petersburg, Russian Federation, 194354
Novartis Investigative Site
S.-Petersburg, Russian Federation, 198205
Novartis Investigative Site
Saint Petersburg, Russian Federation, 195067
Novartis Investigative Site
Saint Petersburg, Russian Federation, 199106
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 194044
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 197341
Novartis Investigative Site
Samara, Russian Federation, 443095
Novartis Investigative Site
Samara, Russian Federation, 443070
Novartis Investigative Site
Sankt-Peterburg, Russian Federation, 197022
Novartis Investigative Site
Saratov, Russian Federation, 410028
Novartis Investigative Site
Saratov, Russian Federation, 410012
Novartis Investigative Site
Smolensk, Russian Federation, 214018
Novartis Investigative Site
St-Peterburg, Russian Federation, 190000
Novartis Investigative Site
St-Petersburg, Russian Federation, 197119
Novartis Investigative Site
St-Petersburg, Russian Federation, 194017
Novartis Investigative Site
St-Petersburg, Russian Federation, 194295
Novartis Investigative Site
St-Petersburg, Russian Federation, 196084
Novartis Investigative Site
St. Petersburg, Russian Federation, 198013
Novartis Investigative Site
St.Petersburg, Russian Federation, 193163
Novartis Investigative Site
Syktyvkar, Russian Federation, 167981
Novartis Investigative Site
Tula, Russian Federation, 300053
Novartis Investigative Site
Tver, Russian Federation, 170036
Novartis Investigative Site
Vladimir, Russian Federation, 600020
Novartis Investigative Site
Volgograd, Russian Federation, 400008
Novartis Investigative Site
Voronezh, Russian Federation, 394065
Novartis Investigative Site
Yaroslavl, Russian Federation, 150003
Novartis Investigative Site
Yaroslavl, Russian Federation, 150062
Singapore
Novartis Investigative Site
Singapore, Singapore, 169609
Novartis Investigative Site
Singapore, Singapore, 308433
Novartis Investigative Site
Singapore, Singapore, 119074
Novartis Investigative Site
Singapore, Singapore, 768825
Slovakia
Novartis Investigative Site
Bratislava, Slovak Republic, Slovakia, 841 04
Novartis Investigative Site
Brezno, Slovak Republic, Slovakia, 977 42
Novartis Investigative Site
Kosice, Slovak Republic, Slovakia, 040 22
Novartis Investigative Site
Levice, Slovak Republic, Slovakia, 93401
Novartis Investigative Site
Presov, Slovak Republic, Slovakia, 080 01
Novartis Investigative Site
Presov, Slovak Republic, Slovakia, 08001
Novartis Investigative Site
Svidnik, Slovak Republic, Slovakia, 08901
Novartis Investigative Site
Vranov nad Toplou, Slovak Republic, Slovakia, 09301
Novartis Investigative Site
Bratislava, Slovakia, 81369
Novartis Investigative Site
Bratislava, Slovakia, 821 07
Novartis Investigative Site
Bratislava, Slovakia, 841 04
Novartis Investigative Site
Bratislava, Slovakia, 851 07
Novartis Investigative Site
Dolny Kubin, Slovakia, 026 01
Novartis Investigative Site
Dunajska Streda, Slovakia, 929 01
Novartis Investigative Site
Kosice, Slovakia, 040 01
Novartis Investigative Site
Kosice, Slovakia, 04001
Novartis Investigative Site
Kralovsky Chlmec, Slovakia, 077 01
Novartis Investigative Site
Levice, Slovakia, 934 01
Novartis Investigative Site
Levice, Slovakia, 934 05
Novartis Investigative Site
Lucenec, Slovakia, 984 01
Novartis Investigative Site
Martin, Slovakia, 036 01
Novartis Investigative Site
Nitra, Slovakia, 949 88
Novartis Investigative Site
Trnava, Slovakia, 917 01
Novartis Investigative Site
Trnava, Slovakia, 91701
South Africa
Novartis Investigative Site
Mthatha, Eastern Cape, South Africa
Novartis Investigative Site
Bloemfontein, Free State, South Africa, 9301
Novartis Investigative Site
Soweto, Gauteng, South Africa, 2013
Novartis Investigative Site
Middelburg, Mpumalanga, South Africa, 1050
Novartis Investigative Site
Paarl, Western Cape, South Africa, 7626
Novartis Investigative Site
Somerset West, Western Cape, South Africa, 7130
Novartis Investigative Site
Alberton, South Africa, 1449
Novartis Investigative Site
Bloemfontein, South Africa, 9301
Novartis Investigative Site
Bloemfontein, South Africa, 9317
Novartis Investigative Site
Breyton, South Africa, 2330
Novartis Investigative Site
Brits, South Africa, 250
Novartis Investigative Site
Cape Town, South Africa, 7405
Novartis Investigative Site
Cape Town, South Africa, 7531
Novartis Investigative Site
Cape Town, South Africa
Novartis Investigative Site
Cape Town, South Africa, 7505
Novartis Investigative Site
Durban, South Africa, 4110
Novartis Investigative Site
Durban, South Africa, 4001
Novartis Investigative Site
Durban, South Africa, 4052
Novartis Investigative Site
East London, South Africa
Novartis Investigative Site
Gatesville, South Africa, 7764
Novartis Investigative Site
Johannesburg, South Africa, 2193
Novartis Investigative Site
Kempton Park, South Africa, 1620
Novartis Investigative Site
Port Elizabeth, South Africa, 6014
Novartis Investigative Site
Pretoria, South Africa
Novartis Investigative Site
Pretoria, South Africa, 0001
Novartis Investigative Site
Pretoria, South Africa, 0184
Novartis Investigative Site
Umkomaas, South Africa, 4170
Novartis Investigative Site
Witbank, South Africa
Novartis Investigative Site
Worcester, South Africa, 6850
Spain
Novartis Investigative Site
Almeria, Andalucia, Spain, 04120
Novartis Investigative Site
Malaga, Andalucia, Spain, 29010
Novartis Investigative Site
Marbella, Andalucia, Spain, 29600
Novartis Investigative Site
Málaga, Andalucia, Spain, 29010
Novartis Investigative Site
Sevilla, Andalucia, Spain, 41014
Novartis Investigative Site
Sevilla, Andalucia, Spain, 41017
Novartis Investigative Site
Barcelona, Catalunya, Spain, 08035
Novartis Investigative Site
Barcelona, Catalunya, Spain, 08003
Novartis Investigative Site
Sant Joan Despí, Cataluña, Spain, 08970
Novartis Investigative Site
Alicante, Comunidad Valenciana, Spain, 03004
Novartis Investigative Site
Requena, Comunidad Valenciana, Spain, 46340
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain, 46010
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain
Novartis Investigative Site
Mérida, Extremadura, Spain, 06800
Novartis Investigative Site
A Coruña, Galicia, Spain, 15006
Novartis Investigative Site
Ferrol, Galicia, Spain, 15405
Novartis Investigative Site
La Coruna, Galicia, Spain, 15006
Novartis Investigative Site
Santiago de Compostela, Galicia, Spain, 15706
Novartis Investigative Site
Vigo, Galicia, Spain, 36211
Novartis Investigative Site
Mallorca, Islas Baleares, Spain, 07198
Novartis Investigative Site
Alcala de Henares, Madrid, Spain, 28805
Novartis Investigative Site
Majadanonda, Madrid, Spain, 28220
Novartis Investigative Site
El Palmar, Murcia, Spain, 30120
Novartis Investigative Site
Madrid, Spain, 28009
Novartis Investigative Site
Madrid, Spain, 28935
Sweden
Novartis Investigative Site
Göteborg, Sweden, 416 85
Novartis Investigative Site
Göteborg, Sweden
Novartis Investigative Site
Helsingborg, Sweden, 25232
Novartis Investigative Site
Härnösand, Sweden, 871 82
Novartis Investigative Site
Karlshamn, Sweden, 37480
Novartis Investigative Site
Lund, Sweden, 221 85
Novartis Investigative Site
Motala, Sweden, 59185
Novartis Investigative Site
Stockholm, Sweden, 141 86
Novartis Investigative Site
Vällingby, Sweden, 162 68
Taiwan
Novartis Investigative Site
Tainan 704, Taiwan ROC, Taiwan
Novartis Investigative Site
Taipei, Taiwan, ROC, Taiwan, 112
Novartis Investigative Site
Changhua, Taiwan, 500
Novartis Investigative Site
Ilan, Taiwan
Novartis Investigative Site
Kaohsiung, Taiwan, 82445
Novartis Investigative Site
Taichung, Taiwan, 40447
Novartis Investigative Site
Taipei, Taiwan, 114
Novartis Investigative Site
Taipei, Taiwan, 10002
Thailand
Novartis Investigative Site
Taladkwan, Nonthaburi, Thailand, 11000
Novartis Investigative Site
Bangkok, Thailand, 10400
Novartis Investigative Site
Khon Kaen, Thailand, 40002
Novartis Investigative Site
Muang, Thailand, 65000
Novartis Investigative Site
Muang, Thailand, 12120
Turkey
Novartis Investigative Site
Adana, Turkey, 01250
Novartis Investigative Site
Ankara, Turkey, 06100
Novartis Investigative Site
Antalya, Turkey, 07070
Novartis Investigative Site
Edirne, Turkey, 22030
Novartis Investigative Site
Etlik / Ankara, Turkey, 06018
Novartis Investigative Site
Haseki / Istanbul, Turkey, 34096
Novartis Investigative Site
Istanbul, Turkey, 34304
Novartis Investigative Site
Istanbul, Turkey, 34093
Novartis Investigative Site
Izmir, Turkey, 35040
Novartis Investigative Site
Izmir, Turkey, 35340
Novartis Investigative Site
Kocaeli, Turkey, 41380
Novartis Investigative Site
Mersin, Turkey, 33079
Novartis Investigative Site
Meselik / Eskisehir, Turkey, 26480
Novartis Investigative Site
Sivas, Turkey, 58140
United Kingdom
Novartis Investigative Site
Bristol, Bs2 8hw, United Kingdom
Novartis Investigative Site
Cambridge, Cambrigdeshire, United Kingdom, CB2 0QQ
Novartis Investigative Site
Durham, County Durham, United Kingdom, DH1 5TW
Novartis Investigative Site
Dorchester, Dorset, United Kingdom, DT1 2JY
Novartis Investigative Site
Brighton, East Sussex, United Kingdom, BN2 5BE
Novartis Investigative Site
Swansea, England, United Kingdom, SA6 6NL
Novartis Investigative Site
Romford, Essex, United Kingdom, RM7 0AG
Novartis Investigative Site
Basingstoke, Hampshire, United Kingdom, RG24 9NA
Novartis Investigative Site
Portsmouth, Hampshire, United Kingdom, PO6 3LY
Novartis Investigative Site
Royal Bridge Wells, Kent, United Kingdom, TN4 8AT
Novartis Investigative Site
Oldham, Lancashire, United Kingdom, OL1 2JH
Novartis Investigative Site
Leicester, Leicestershire, United Kingdom, LE2 7LX
Novartis Investigative Site
Craigavon, Northern Ireland, United Kingdom, BT63 5QQ
Novartis Investigative Site
Dundee, Perthshire, United Kingdom, DD1 2BU
Novartis Investigative Site
Taunton, Somerset, United Kingdom, TA1 5DA
Novartis Investigative Site
Yeovil, Somerset, United Kingdom, BA21 4AT
Novartis Investigative Site
Sheffield, South Yorkshire, United Kingdom, S10 2JF
Novartis Investigative Site
Redhill, Surrey, United Kingdom, RH1 5RH
Novartis Investigative Site
South Shields, Tyne and Wear, United Kingdom, NE34 0PL
Novartis Investigative Site
Dudley, West Midlands, United Kingdom, DY1 2HQ
Novartis Investigative Site
Sutton Coldfield, West Midlands, United Kingdom, B75 7RR
Novartis Investigative Site
Birmingham, United Kingdom, B18 7QH
Novartis Investigative Site
Blackpool, United Kingdom, FY3 8NR
Novartis Investigative Site
Bournemouth, United Kingdom, BH7 7DW
Novartis Investigative Site
Bradford, United Kingdom, BD9 6RJ
Novartis Investigative Site
Cheshire, United Kingdom, CW1 4QJ
Novartis Investigative Site
Coventry, United Kingdom, CV2 2DX
Novartis Investigative Site
Croydon, United Kingdom, CR7 7YE
Novartis Investigative Site
Darlington, United Kingdom, DL3 6HX
Novartis Investigative Site
Exeter, United Kingdom, EX2 5AX
Novartis Investigative Site
Inverness, United Kingdom, IV2 3UJ
Novartis Investigative Site
Kent, United Kingdom, DA2 8DA
Novartis Investigative Site
Liverpool, United Kingdom, L7 8XP
Novartis Investigative Site
London, United Kingdom, W1G 8PH
Novartis Investigative Site
Londonderry, United Kingdom, BT47 1SB
Novartis Investigative Site
Manchester, United Kingdom, M13 9WL
Novartis Investigative Site
Middlesborough, United Kingdom, TS4 3BW
Novartis Investigative Site
Milton Keynes, United Kingdom, MK6 5LD
Novartis Investigative Site
Newport, United Kingdom, P030 5TG
Novartis Investigative Site
Newport, United Kingdom, NP20 2UB
Novartis Investigative Site
Norwich, United Kingdom, NR4 7UY
Novartis Investigative Site
Poole, United Kingdom, BH15 2JB
Novartis Investigative Site
Rotherham, United Kingdom, S60 2OD
Novartis Investigative Site
Stevenage, United Kingdom, SG1 4AB
Novartis Investigative Site
Sunderland, United Kingdom, SR4 7TP
Novartis Investigative Site
Surrey, United Kingdom, SM5 1AA
Novartis Investigative Site
Vale of Glamorgan, United Kingdom, CF64 2XX
Novartis Investigative Site
Worcester, United Kingdom, WR5 1DD
Novartis Investigative Site
York, United Kingdom, YO31 8HE
Venezuela
Novartis Investigative Site
Caracas, Distrito Capital, Venezuela, 1060
Novartis Investigative Site
Caracas, Estado Miranda, Venezuela, 1061
Novartis Investigative Site
Maturin, Estado Monagas, Venezuela, 6201
Novartis Investigative Site
Maracaibo, Estado Zulia, Venezuela
Novartis Investigative Site
Maracaibo, Estado Zulia, Venezuela, 4011
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

No publications provided by Novartis

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier: NCT01035255     History of Changes
Other Study ID Numbers: CLCZ696B2314, 2009-015834-31
Study First Received: December 16, 2009
Last Updated: October 10, 2014
Health Authority: United States: Food and Drug Administration
Argentina: National Administration of Drugs, Foods and Medical Technology
Belgium: Federal Agency for Medicines and Health Products, FAMHP
Brazil: Ministry of Health
Bulgaria: Ministry of Health
Canada: Health Canada
Chile: Comisión Nacional de Investigación Científica y Tecnológica
China: Food and Drug Administration
Colombia: National Institute of Food and Drug Vigilance
Czech Republic: State Institute for Drug Control
Denmark: Danish Medicines Agency
Ecuador: Public Health Ministry
Estonia: The State Agency of Medicine
Finland: Finnish Medicines Agency
France: Sanitary Safety of Health Products Agency
Germany: Federal Institute for Drugs and Medical Devices
Guatemala: Ministry of health
Hong Kong: Department of Health
Hungary: National Institute of Pharmacy
Iceland: Icelandic Medicines Control Agency
India: Central Drug Standard Organization
Israel: Ministry of Health
Italy: National Institute of Health
Korea: Korea Food and Drug Administration
Latvia: State Agency of Medicines
Lithuania: State Medicines Control Agency
Malaysia: Ministry of Health
Mexico: Ministry of Health
Netherlands: Medicines Evaluation Board
Panama: Ministry of Health
Peru: General Directorate of Pharmaceuticals, Devices, and Drugs
Philippines: Bureau of Food and Drugs
Poland: Ministry of Health
Portugal: National Institute of Pharmacy and Medicines
Romania: National Medicines Agency
Russia: Pharmacological Committee, Ministry of Health
Singapore: Center for Drug Administration
Slovakia: State Institute for Drug Control
South Africa: Medicines Control Council
Spain: Spanish Drug Agency
Sweden: Medical Products Agency
Taiwan: Department of Health
Thailand: Ministry of Public Health
Turkey: General Directorate of Pharmaceuticals and Pharmacy
United Kingdom: Medicines and Healthcare Products Regulatory Agency
Venezuela: Ministry of Health and Social Development
Argentina: Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica
Belgium: Federal Agency for Medicinal Products and Health Products
Colombia: INVIMA Instituto Nacional de Vigilancia de Medicamentos y Alimentos
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Guatemala: Ministry of Public Health and Social Assistance
India: Central Drugs Standard Control Organization
Korea: Food and Drug Administration
Lithuania: State Medicine Control Agency - Ministry of Health
Netherlands: Medicines Evaluation Board (MEB)
Portugal: National Pharmacy and Medicines Institute
Spain: Spanish Agency of Medicines

Keywords provided by Novartis:
chronic heart failure
cardiovascular death
hospitalization
outcome study
BNP
KCCQ
eGFR

Additional relevant MeSH terms:
Heart Failure
Cardiovascular Diseases
Heart Diseases
Enalapril
Enalaprilat
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Cardiovascular Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protease Inhibitors
Therapeutic Uses

ClinicalTrials.gov processed this record on October 22, 2014