Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial (SOLID-TIMI 52)

This study has been completed.
Sponsor:
Collaborator:
The TIMI Study Group
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT01000727
First received: October 22, 2009
Last updated: October 23, 2014
Last verified: October 2014
  Purpose

This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or urgent coronary revascularization (e.g. medical procedures performed to restore the normal blood flow in patients with atherosclerosis)) when treatment is started within 30 days after an acute coronary syndrome (also called ACS).


Condition Intervention Phase
Acute Coronary Syndrome
Drug: Darapladib 160 mg
Drug: Placebo
Other: Standard Therapy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Clinical Outcomes Study of Darapladib Versus Placebo in Subjects Following Acute Coronary Syndrome to Compare the Incidence of Major Adverse Cardiovascular Events (MACE).

Resource links provided by NLM:


Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Time to the first occurrence of any component of the composite of major coronary events (i.e., Coronary Heart Disease (CHD) death, non-fatal myocardial infarction (MI), or urgent coronary revascularization for myocardial ischemia). [ Time Frame: Up to 5 years. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • The composite measure of Major Adverse Cardiovascular Event (MACE) that includes cardiovascular (CV) death (death due to a cardiovascular cause), non-fatal MI, or non-fatal stroke. [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • Individual components of MACE (CV death, MI (fatal and non-fatal), stroke (fatal and non-fatal)). [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • Individual components of major coronary events (CHD death, MI (fatal and non-fatal), urgent coronary revascularization for myocardial ischemia). [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • Composite measure of total coronary events that incl. first occurrence of CHD death, non-fatal MI, hosp. for unstable angina(UA), or any coronary revasc. proc.(excl. percutaneous coronary intervention(PCI) planned prior to but performed after rand.). [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • Any coronary revascularization procedures (excluding PCI planned prior to randomization but performed after randomization). [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • The first occurrence of any component of the composite of all-cause mortality, non-fatal MI, or non-fatal stroke. [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • The composite of CHD death and non-fatal MI. [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]
  • All cause mortality. [ Time Frame: Up to 1400 days. ] [ Designated as safety issue: No ]

Enrollment: 13026
Study Start Date: December 2009
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Darapladib 160 mg
Single daily oral tablet
Drug: Darapladib 160 mg
Lp-PLA2 inhibitor
Other Name: SB-480848
Other: Standard Therapy
Guideline mandated therapy for individual's condition
Placebo Comparator: Placebo
Single daily oral tablet
Drug: Placebo
Placebo administered
Other: Standard Therapy
Guideline mandated therapy for individual's condition

Detailed Description:

Subjects who qualify for the study will be randomized 1:1 to either darapladib or placebo administered in addition to standard therapy. Following the baseline visit, subjects will be expected to return for clinic visits at 1 month, 3 months, 6 months and every 6 months until the end of the study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Signed written informed consent.
  • Men or women at least 18 years old (in Taiwan, at least 20 years old). Women must be post-menopausal or using a highly effective method for avoidance of pregnancy.
  • Hospitalization for acute coronary syndrome (ACS) within 30 days prior to study entry.
  • Clinically stable for 24 hours prior to study entry.
  • A planned percutaneous coronary intervention (PCI) should be performed prior to study entry, whenever possible.
  • At least one of the following:
  • At least 60 years old.
  • Myocardial infarction prior to the qualifying ACS event.
  • Diabetes mellitus requiring treatment with medication.
  • Diagnosed mild or moderate reduction in kidney function.
  • Cerebrovascular disease (carotid artery disease or ischemic stroke more than 3 months prior to study entry) OR peripheral artery disease.

Exclusion Criteria:

  • ACS symptoms or lab results not believed to be caused by a narrowing or blocked coronary artery.
  • No major coronary artery with a blockage of more than 50% (unless all stenoses are successfully treated by PCI).
  • Planned coronary artery bypass graft (CABG) surgery, or CABG surgery performed after the qualifying ACS event and prior to study entry.
  • Certain types of liver disease.
  • Severe reduction in kidney function OR removal of a kidney OR kidney transplant.
  • Severe heart failure.
  • Blood pressure higher than normal despite lifestyle changes and treatment with medications.
  • Any life-threatening disease with a life expectancy of less than 2 years (other than heart disease) that may prevent the subject from completing the study.
  • Severe asthma that is poorly controlled with medication.
  • Pregnancy (Note: A pregnancy test will be performed on all non-sterile women prior to study entry).
  • Previous severe allergic reaction to food, medications, drink, insect stings, etc.
  • Drug or alcohol abuse within the past 6 months. Mental/psychological impairment that may prevent the subject from complying with study procedures or understanding the goal and potential risks of participating in the study.
  • Certain medications that may interfere with the study medication (these will be identified by the study doctor).
  • If both birth parents are at least 50% Japanese, Chinese, or Korean ancestry, must have a blood sample collected for Lp-PLA2 activity. Those with Lp-PLA2 activity less than or equal to 20.0 nmol/min/mL are excluded.
  • Previously took darapladib (SB-480848).
  • Participation in a study of an investigational medication within the past 30 days.
  • Current participation in a study of an investigational device.
  • Any other reason the investigator deems the subject should not participate in the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01000727

  Hide Study Locations
Locations
United States, Alabama
GSK Investigational Site
Birmingham, Alabama, United States, 35243
GSK Investigational Site
Birmingham, Alabama, United States, 35294
GSK Investigational Site
Huntsville, Alabama, United States, 35801
GSK Investigational Site
Mobile, Alabama, United States, 36604
GSK Investigational Site
Mobile, Alabama, United States, 36608
United States, Alaska
GSK Investigational Site
Anchorage, Alaska, United States, 99508
United States, Arizona
GSK Investigational Site
Cottonwood, Arizona, United States, 86326
GSK Investigational Site
Glendale, Arizona, United States, 85306
GSK Investigational Site
Tucson, Arizona, United States, 85724
GSK Investigational Site
Tucson, Arizona, United States, 85723
GSK Investigational Site
Tucson, Arizona, United States, 85710
United States, Arkansas
GSK Investigational Site
Fort Smith, Arkansas, United States, 72903
GSK Investigational Site
Jonesboro, Arkansas, United States, 72401
GSK Investigational Site
Little Rock, Arkansas, United States, 72205
United States, California
GSK Investigational Site
Bakersfield, California, United States, 93308
GSK Investigational Site
Bakersfield, California, United States, 93309
GSK Investigational Site
Beverly Hills, California, United States, 90211
GSK Investigational Site
Fresno, California, United States, 93721
GSK Investigational Site
Glendale, California, United States, 91204
GSK Investigational Site
La Mesa, California, United States, 91942
GSK Investigational Site
Lomita, California, United States, 90717
GSK Investigational Site
Los Alamitos, California, United States, 90720
GSK Investigational Site
Los Angeles, California, United States, 90015
GSK Investigational Site
Los Angeles, California, United States, 90073
GSK Investigational Site
Mission Hills, California, United States, 91345
GSK Investigational Site
Roseville, California, United States, 95661
GSK Investigational Site
Sacramento, California, United States, 95819
GSK Investigational Site
San Diego, California, United States, 92161
GSK Investigational Site
Santa Ana, California, United States, 92704
GSK Investigational Site
Santa Ana, California, United States, 92705
GSK Investigational Site
Stockton, California, United States, 95204
GSK Investigational Site
Thousand Oaks, California, United States, 91360
GSK Investigational Site
Torrance, California, United States, 90509
GSK Investigational Site
Ventura, California, United States, 93003
United States, Colorado
GSK Investigational Site
Colorado Springs, Colorado, United States, 80920
GSK Investigational Site
Golden, Colorado, United States, 80401
GSK Investigational Site
Greeley, Colorado, United States, 80631
GSK Investigational Site
Littleton, Colorado, United States, 80120
GSK Investigational Site
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
GSK Investigational Site
Bridgeport, Connecticut, United States, 06610
GSK Investigational Site
Bridgeport, Connecticut, United States, 06606
GSK Investigational Site
Guilford, Connecticut, United States, 06437
GSK Investigational Site
Hartford, Connecticut, United States, 06067
United States, Florida
GSK Investigational Site
Atlantis, Florida, United States, 33462
GSK Investigational Site
Aventura, Florida, United States, 33180
GSK Investigational Site
Brandon, Florida, United States, 33511
GSK Investigational Site
Clearwater, Florida, United States, 33756
GSK Investigational Site
Daytona Beach, Florida, United States, 32114
GSK Investigational Site
Daytona Beach, Florida, United States, 32117
GSK Investigational Site
Fleming Island, Florida, United States, 32003
GSK Investigational Site
Fort Lauderdale, Florida, United States, 33316
GSK Investigational Site
Gainesville, Florida, United States, 32610
GSK Investigational Site
Gulf Breeze, Florida, United States, 32561
GSK Investigational Site
Hollywood, Florida, United States, 33021
GSK Investigational Site
Inverness, Florida, United States, 34452
GSK Investigational Site
Jacksonville, Florida, United States, 32216
GSK Investigational Site
Jacksonville, Florida, United States, 32207
GSK Investigational Site
Jacksonville, Florida, United States, 32209
GSK Investigational Site
Jacksonville Beach, Florida, United States, 32250
GSK Investigational Site
Jupiter, Florida, United States, 33458
GSK Investigational Site
Kissimmee, Florida, United States, 34741
GSK Investigational Site
Miramar, Florida, United States, 33025
GSK Investigational Site
Ocala, Florida, United States, 34471
GSK Investigational Site
Palm Beach Gardens, Florida, United States, 33410
GSK Investigational Site
Pensacola, Florida, United States, 32501
GSK Investigational Site
Plantation, Florida, United States, 33317
GSK Investigational Site
Port Charlotte, Florida, United States, 33952
GSK Investigational Site
Safety Harbor, Florida, United States, 34695
GSK Investigational Site
Sarasota, Florida, United States, 34232
GSK Investigational Site
St. Petersburg, Florida, United States, 33713
GSK Investigational Site
Tallahassee, Florida, United States, 32308
GSK Investigational Site
Trinity, Florida, United States, 34655
GSK Investigational Site
Vero Beach, Florida, United States, 32960
GSK Investigational Site
Wellington, Florida, United States, 33449
United States, Georgia
GSK Investigational Site
Atlanta, Georgia, United States, 30342
GSK Investigational Site
Augusta, Georgia, United States, 30901
GSK Investigational Site
Cumming, Georgia, United States, 30041
United States, Idaho
GSK Investigational Site
Boise, Idaho, United States, 83712
United States, Illinois
GSK Investigational Site
Aurora, Illinois, United States, 60504
GSK Investigational Site
Bannockburn, Illinois, United States, 60015
GSK Investigational Site
Chicago, Illinois, United States, 60612
GSK Investigational Site
Melrose Park, Illinois, United States, 60160
GSK Investigational Site
Mokena, Illinois, United States, 60448
GSK Investigational Site
North Chicago, Illinois, United States, 60064
GSK Investigational Site
Oakbrook Terrace, Illinois, United States, 60181
GSK Investigational Site
Park Ridge, Illinois, United States, 60068
GSK Investigational Site
Peoria, Illinois, United States, 61614
GSK Investigational Site
Rock Island, Illinois, United States, 61201
United States, Indiana
GSK Investigational Site
Avon, Indiana, United States, 46123
GSK Investigational Site
Fort Wayne, Indiana, United States, 46804
GSK Investigational Site
Hammond, Indiana, United States, 46320
GSK Investigational Site
Indianapolis, Indiana, United States, 46237
GSK Investigational Site
Indianapolis, Indiana, United States, 46290
GSK Investigational Site
Muncie, Indiana, United States, 47303
GSK Investigational Site
Munster, Indiana, United States, 46321
GSK Investigational Site
South Bend, Indiana, United States, 46601-1066
GSK Investigational Site
Valparaiso, Indiana, United States, 46383
United States, Iowa
GSK Investigational Site
Iowa City, Iowa, United States, 52242
GSK Investigational Site
West Des Moines, Iowa, United States, 50266
United States, Kentucky
GSK Investigational Site
Crestview Hill, Kentucky, United States, 41017
GSK Investigational Site
Lexington, Kentucky, United States, 40536-0294
GSK Investigational Site
Louisville, Kentucky, United States, 40207
GSK Investigational Site
Louisville, Kentucky, United States, 40205
United States, Louisiana
GSK Investigational Site
Alexandria, Louisiana, United States, 71301
GSK Investigational Site
Lafayette, Louisiana, United States, 70506
GSK Investigational Site
Lake Charles, Louisiana, United States, 70601
GSK Investigational Site
Shreveport, Louisiana, United States, 71105
United States, Maine
GSK Investigational Site
Bangor, Maine, United States, 04401
GSK Investigational Site
Lewiston, Maine, United States, 04240
GSK Investigational Site
Scarborough, Maine, United States, 04074
United States, Maryland
GSK Investigational Site
Baltimore, Maryland, United States, 21229
GSK Investigational Site
Baltimore, Maryland, United States, 21201
GSK Investigational Site
Baltimore, Maryland, United States, 21208
GSK Investigational Site
Baltimore, Maryland, United States, 21236
GSK Investigational Site
Baltimore, Maryland, United States, 21218
GSK Investigational Site
Bel Air, Maryland, United States, 21014
GSK Investigational Site
Columbia, Maryland, United States, 21044
GSK Investigational Site
Salisbury, Maryland, United States, 21801
GSK Investigational Site
Townson, Maryland, United States, 21204
GSK Investigational Site
Towson, Maryland, United States, 21204
United States, Massachusetts
GSK Investigational Site
Ayer, Massachusetts, United States, 01432
GSK Investigational Site
Boston, Massachusetts, United States, 02111
GSK Investigational Site
Boston, Massachusetts, United States, 02115
GSK Investigational Site
Fall River, Massachusetts, United States, 02720
GSK Investigational Site
Springfield, Massachusetts, United States, 01199
GSK Investigational Site
Worcester, Massachusetts, United States, 01655
United States, Michigan
GSK Investigational Site
Ann Arbor, Michigan, United States, 48109
GSK Investigational Site
Dearborn, Michigan, United States, 48124
GSK Investigational Site
Detroit, Michigan, United States, 48201
GSK Investigational Site
Flint, Michigan, United States, 48532
GSK Investigational Site
Kalamazoo, Michigan, United States, 49048
GSK Investigational Site
Marquette, Michigan, United States, 49855
GSK Investigational Site
Pontiac, Michigan, United States, 48341-2985
GSK Investigational Site
Troy, Michigan, United States, 48085
GSK Investigational Site
Ypsilanti, Michigan, United States, 48197
United States, Minnesota
GSK Investigational Site
Duluth, Minnesota, United States, 55805
GSK Investigational Site
Minneapolis, Minnesota, United States, 55426
GSK Investigational Site
Robbinsdale, Minnesota, United States, 55422
GSK Investigational Site
Saint Paul, Minnesota, United States, 55101
GSK Investigational Site
St Cloud, Minnesota, United States, 56303
United States, Mississippi
GSK Investigational Site
Tupelo, Mississippi, United States, 38801
United States, Missouri
GSK Investigational Site
Columbia, Missouri, United States, 65212
GSK Investigational Site
Joplin, Missouri, United States, 64804
GSK Investigational Site
kansas City, Missouri, United States, 64114
GSK Investigational Site
Springfield, Missouri, United States, 65804
GSK Investigational Site
St Louis, Missouri, United States, 63110
GSK Investigational Site
St.Louis, Missouri, United States, 63128
United States, Montana
GSK Investigational Site
Columbia, Montana, United States, 65201
GSK Investigational Site
Great Falls, Montana, United States, 59405
GSK Investigational Site
Kalispell, Montana, United States, 59901
United States, Nebraska
GSK Investigational Site
Grand Island, Nebraska, United States, 68803
GSK Investigational Site
Lincoln, Nebraska, United States, 68526
GSK Investigational Site
Omaha, Nebraska, United States, 68131
GSK Investigational Site
Papillion, Nebraska, United States, 68046
United States, Nevada
GSK Investigational Site
Las Vegas, Nevada, United States, 89103
United States, New Jersey
GSK Investigational Site
Browns Mills, New Jersey, United States, 08015
GSK Investigational Site
Elizabeth, New Jersey, United States, 07202
GSK Investigational Site
Elmer, New Jersey, United States, 8318
GSK Investigational Site
Haddon Heights, New Jersey, United States, 08035
GSK Investigational Site
Linden, New Jersey, United States, 07036
GSK Investigational Site
Paterson, New Jersey, United States, 07503
GSK Investigational Site
Pomona, New Jersey, United States, 8240
GSK Investigational Site
Sewell, New Jersey, United States, 08080
GSK Investigational Site
Somerset, New Jersey, United States, 08873
GSK Investigational Site
Summit, New Jersey, United States, 07902
GSK Investigational Site
Voorhees, New Jersey, United States, 08043
GSK Investigational Site
West Orange, New Jersey, United States, 07052
United States, New Mexico
GSK Investigational Site
Albuquerque, New Mexico, United States, 87131-0001
United States, New York
GSK Investigational Site
Albany, New York, United States, 12211
GSK Investigational Site
Bronx, New York, United States, 10467
GSK Investigational Site
Brooklyn, New York, United States, 11219
GSK Investigational Site
Buffalo, New York, United States, 14215
GSK Investigational Site
Cortlandt Manor, New York, United States, 10567
GSK Investigational Site
New York, New York, United States, 10021
GSK Investigational Site
New York, New York, United States, 10016
GSK Investigational Site
New York, New York, United States, 10001
GSK Investigational Site
Roslyn, New York, United States, 11576
GSK Investigational Site
Stony Brook, New York, United States, 11794
GSK Investigational Site
Syracuse, New York, United States, 13202
GSK Investigational Site
Troy, New York, United States, 12180
GSK Investigational Site
Williamsville, New York, United States, 14221
United States, North Carolina
GSK Investigational Site
Asheville, North Carolina, United States, 28803
GSK Investigational Site
Burlington, North Carolina, United States, 27215
GSK Investigational Site
Charlotte, North Carolina, United States, 28204
GSK Investigational Site
Concord, North Carolina, United States, 28025
GSK Investigational Site
Gastonia, North Carolina, United States, 28054
GSK Investigational Site
Greensboro, North Carolina, United States, 27401
GSK Investigational Site
Huntersville, North Carolina, United States, 28078
GSK Investigational Site
Matthews, North Carolina, United States, 28105
GSK Investigational Site
Monroe, North Carolina, United States, 28112
GSK Investigational Site
Pinehurst, North Carolina, United States, 28374
GSK Investigational Site
Raleigh, North Carolina, United States, 27610
GSK Investigational Site
Rocky Mount, North Carolina, United States, 27804
GSK Investigational Site
Salisbury, North Carolina, United States, 28144
GSK Investigational Site
Sanford, North Carolina, United States, 27330
GSK Investigational Site
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
GSK Investigational Site
Grand Forks, North Dakota, United States, 58201
United States, Ohio
GSK Investigational Site
Canton, Ohio, United States, 44718
GSK Investigational Site
Cincinnati, Ohio, United States, 45267
GSK Investigational Site
Cincinnati, Ohio, United States, 45219
GSK Investigational Site
Cleveland, Ohio, United States, 44106
GSK Investigational Site
Dayton, Ohio, United States, 45414
GSK Investigational Site
Elyria, Ohio, United States, 44035
GSK Investigational Site
Fairfield, Ohio, United States, 45014
GSK Investigational Site
Fairview Park, Ohio, United States, 44126
GSK Investigational Site
Lorain, Ohio, United States, 44053
GSK Investigational Site
Mansfield, Ohio, United States, 44906
GSK Investigational Site
Middleburg Heights, Ohio, United States, 44130
GSK Investigational Site
Oakbrook Terrace, Ohio, United States, 60181
GSK Investigational Site
Sandusky, Ohio, United States, 44870
GSK Investigational Site
Toledo, Ohio, United States, 43614
GSK Investigational Site
Toledo, Ohio, United States, 43606
GSK Investigational Site
Youngstown, Ohio, United States, 44501-1790
GSK Investigational Site
Zaneville, Ohio, United States, 43701
United States, Oklahoma
GSK Investigational Site
Midwest City, Oklahoma, United States, 73110
GSK Investigational Site
Oklahoma, Oklahoma, United States, 73104
GSK Investigational Site
Oklahoma City, Oklahoma, United States, 73112
United States, Oregon
GSK Investigational Site
Portland, Oregon, United States, 97220
GSK Investigational Site
Portland, Oregon, United States, 97239
United States, Pennsylvania
GSK Investigational Site
Allentown, Pennsylvania, United States, 18103
GSK Investigational Site
Beaver, Pennsylvania, United States, 15009
GSK Investigational Site
Bethlehem, Pennsylvania, United States, 18015
GSK Investigational Site
Camp Hill, Pennsylvania, United States, 17011
GSK Investigational Site
Chambersburg, Pennsylvania, United States, 17201
GSK Investigational Site
Doylestown, Pennsylvania, United States, 18901
GSK Investigational Site
Erie, Pennsylvania, United States, 16502
GSK Investigational Site
Hershey, Pennsylvania, United States, 17033
GSK Investigational Site
Jenkintown, Pennsylvania, United States, 19046
GSK Investigational Site
Jersey Shore, Pennsylvania, United States, 17740
GSK Investigational Site
Lancaster, Pennsylvania, United States, 17604
GSK Investigational Site
Landsdale, Pennsylvania, United States, 19446
GSK Investigational Site
Leetsdale, Pennsylvania, United States, 15056
GSK Investigational Site
Philadelphia, Pennsylvania, United States, 19141
GSK Investigational Site
Pittsburgh, Pennsylvania, United States, 15212
GSK Investigational Site
Pittsburgh, Pennsylvania, United States, 15240
GSK Investigational Site
Sayre, Pennsylvania, United States, 18840
GSK Investigational Site
Scranton, Pennsylvania, United States, 18501
GSK Investigational Site
Sellersville, Pennsylvania, United States, 18960
GSK Investigational Site
West Chester, Pennsylvania, United States, 19380
GSK Investigational Site
York, Pennsylvania, United States, 17405
United States, South Carolina
GSK Investigational Site
Charleston, South Carolina, United States, 29401
GSK Investigational Site
Charleston, South Carolina, United States, 29425
GSK Investigational Site
Columbia, South Carolina, United States, 29204
GSK Investigational Site
Greenville, South Carolina, United States, 29607
United States, South Dakota
GSK Investigational Site
Rapid City, South Dakota, United States, 57701
United States, Tennessee
GSK Investigational Site
Chattanooga, Tennessee, United States, 37404
GSK Investigational Site
Columbia, Tennessee, United States, 38401
GSK Investigational Site
Jackson, Tennessee, United States, 38301
GSK Investigational Site
Jackson, Tennessee, United States, 38085
GSK Investigational Site
Johnson City, Tennessee, United States, 37604
GSK Investigational Site
Nashville, Tennessee, United States, 37205
GSK Investigational Site
Oak Ridge, Tennessee, United States, 37830
United States, Texas
GSK Investigational Site
Amarillo, Texas, United States, 79106
GSK Investigational Site
Austin, Texas, United States, 78705
GSK Investigational Site
Corpus Christi/Texas, Texas, United States, 78404
GSK Investigational Site
Dallas, Texas, United States, 75226
GSK Investigational Site
Dallas, Texas, United States, 75390-8887
GSK Investigational Site
Fort Worth, Texas, United States, 76104
GSK Investigational Site
Galveston, Texas, United States, 77555-0553
GSK Investigational Site
Harker Heights, Texas, United States, 76548
GSK Investigational Site
Houston, Texas, United States, 77090
GSK Investigational Site
Houston, Texas, United States, 77002
GSK Investigational Site
Houston, Texas, United States, 77124
GSK Investigational Site
Houston, Texas, United States, 77030
GSK Investigational Site
Katy, Texas, United States, 77493
GSK Investigational Site
Kingwood, Texas, United States, 77339
GSK Investigational Site
Round Rock, Texas, United States, 78681
GSK Investigational Site
San Antonio, Texas, United States, 78229
GSK Investigational Site
San Marcos, Texas, United States, 78666
GSK Investigational Site
Sugar Land, Texas, United States, 77479
GSK Investigational Site
Tyler, Texas, United States, 75708
GSK Investigational Site
Victoria, Texas, United States, 77901
United States, Virginia
GSK Investigational Site
Lynchburg, Virginia, United States, 24501
GSK Investigational Site
Midlothian, Virginia, United States, 23114
GSK Investigational Site
Richmond, Virginia, United States, 23298
GSK Investigational Site
Richmond, Virginia, United States, 23249
GSK Investigational Site
Richmond, Virginia, United States, 23294
GSK Investigational Site
Winchester, Virginia, United States, 22601
United States, Washington
GSK Investigational Site
Bellevue, Washington, United States, 98004
GSK Investigational Site
Bellingham, Washington, United States, 98225
GSK Investigational Site
Burien, Washington, United States, 98166
GSK Investigational Site
Everett, Washington, United States, 98201
GSK Investigational Site
Kirkland, Washington, United States, 98034
GSK Investigational Site
Spokane, Washington, United States, 99204
GSK Investigational Site
Spokane, Washington, United States, 99204-2334
GSK Investigational Site
Tacoma, Washington, United States, 98405
GSK Investigational Site
Walla Walla, Washington, United States, 99362
United States, Wisconsin
GSK Investigational Site
Beloit, Wisconsin, United States, 53511
GSK Investigational Site
Green Bay, Wisconsin, United States, 54301
GSK Investigational Site
Madison, Wisconsin, United States, 53713
GSK Investigational Site
Wausau, Wisconsin, United States, 54401
Argentina
GSK Investigational Site
Capital Federal, Buenos Aires, Argentina, C1180AAX
GSK Investigational Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1425AST
GSK Investigational Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1179AAB
GSK Investigational Site
Mar del Plata, Buenos Aires, Argentina, B7600FZN
GSK Investigational Site
Ramos Mejia, Buenos Aires, Argentina, B1704ETD
GSK Investigational Site
San Justo, Buenos Aires, Argentina, B1754FPI
GSK Investigational Site
San Nicolas, Buenos Aires, Argentina, B2900DMH
GSK Investigational Site
Cordoba, Córdova, Argentina, X5000AAW
GSK Investigational Site
Cordoba, Córdova, Argentina, X5000EPU
GSK Investigational Site
Rosario, Santa Fe, Argentina, 2002
GSK Investigational Site
Rosario, Santa Fe, Argentina, S2002OUR
GSK Investigational Site
Rosario, Santa Fe, Argentina, S2000BIF
GSK Investigational Site
Rosario, Santa Fe, Argentina, S2000CVD
GSK Investigational Site
Rosario, Santa Fe, Argentina, S2000ODA
GSK Investigational Site
Buenos Aires, Argentina, 1425
GSK Investigational Site
Cipolletti, Argentina, R8324CVM
GSK Investigational Site
Ciudad Autonoma de Buenos Aires, Argentina, C1181ACH
GSK Investigational Site
Corrientes, Argentina, W3400AMZ
GSK Investigational Site
Haedo, Buenos Aires, Argentina, B1706AJU
GSK Investigational Site
San Miguel de Tucuman, Argentina, T4000IFL
GSK Investigational Site
Santa fe, Argentina, 3000
GSK Investigational Site
Sante Fe, Argentina, S3000GCI
GSK Investigational Site
Sante Fe, Argentina, S3000FSO
GSK Investigational Site
Tucuman, Argentina, T4000ICL
GSK Investigational Site
Zárate, Argentina, B2800DGH
Australia, Australian Capital Territory
GSK Investigational Site
Garran, Australian Capital Territory, Australia, 2606
Australia, New South Wales
GSK Investigational Site
Camperdown, New South Wales, Australia, 2050
GSK Investigational Site
Gosford, New South Wales, Australia, 2250
Australia, Queensland
GSK Investigational Site
Auchenflower, Queensland, Australia, 4066
GSK Investigational Site
Herston, Queensland, Australia, 4029
GSK Investigational Site
Milton, Queensland, Australia, 4064
Australia, South Australia
GSK Investigational Site
Adelaide, South Australia, Australia, 5000
GSK Investigational Site
Elizabeth Vale, South Australia, Australia, 5112
Australia, Tasmania
GSK Investigational Site
Hobart, Tasmania, Australia, 7000
Australia, Victoria
GSK Investigational Site
Box Hill, Victoria, Australia, 3128
GSK Investigational Site
Nedlands, Victoria, Australia, 6009
Australia, Western Australia
GSK Investigational Site
Fremantle, Western Australia, Australia, 6160
Australia
GSK Investigational Site
Ashford, Australia, 5035
Belgium
GSK Investigational Site
Aalst, Belgium, 9300
GSK Investigational Site
Bonheiden, Belgium, 2820
GSK Investigational Site
Brussels, Belgium, 1090
GSK Investigational Site
Brussels, Belgium, 1000
GSK Investigational Site
Bruxelles, Belgium, 1200
GSK Investigational Site
Edegem, Belgium, 2650
GSK Investigational Site
Genk, Belgium, 3600
GSK Investigational Site
La Louvière, Belgium, 7100
GSK Investigational Site
Leuven, Belgium, 3000
GSK Investigational Site
Liège, Belgium, 4000
GSK Investigational Site
Roeselaere, Belgium, 8800
Brazil
GSK Investigational Site
Salvador, Bahía, Brazil, 41810010
GSK Investigational Site
Fortaleza, Ceará, Brazil, 60864-190
GSK Investigational Site
Goiânia - GO, Goiás, Brazil, 74605-050
GSK Investigational Site
Belo Horizonte, Minas Gerais, Brazil, 30130-110
GSK Investigational Site
Belo Horizonte, Minas Gerais, Brazil, 30150-221.
GSK Investigational Site
Campina Grande do Sul, Paraná, Brazil, 83430000
GSK Investigational Site
Curitiba, Paraná, Brazil, 80730-150
GSK Investigational Site
Pelotas, Rio Grande Do Sul, Brazil, 96015-290
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 90610000
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 91350-200
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 90880-480
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 90020-090
GSK Investigational Site
Porto Alegre, Rio Grande Do Sul, Brazil, 90620001
GSK Investigational Site
Natal, Rio Grande Du Norte, Brazil, 59020-100
GSK Investigational Site
Marília, São Paulo, Brazil, 17515-000
GSK Investigational Site
Sao Jose do Rio Preto, São Paulo, Brazil, 15090-000
GSK Investigational Site
Sao Paulo, São Paulo, Brazil, 04024-900
GSK Investigational Site
São José do Rio Preto, São Paulo, Brazil, 15015210
GSK Investigational Site
Votuporanga, São Paulo, Brazil, 15500-003
GSK Investigational Site
Bahia, Brazil, 40050-410
GSK Investigational Site
Brasília, Brazil, 70658-700
GSK Investigational Site
Campinas, Brazil, 13060-803
GSK Investigational Site
Campo Grande, Brazil, 79080-090
GSK Investigational Site
Rio De Janeiro, Brazil, RJ 22240-000
GSK Investigational Site
Rio de Janeiro, Brazil, 21041-030
GSK Investigational Site
São Paulo, Brazil, 05508-900
GSK Investigational Site
São Paulo, Brazil, 04012-180
GSK Investigational Site
São Paulo, Brazil, 05403000
GSK Investigational Site
São Paulo - SP, Brazil, 01323-900
GSK Investigational Site
Uberlandia, Brazil, 38400-902
Bulgaria
GSK Investigational Site
Dimitrovgrad, Bulgaria, 6400
GSK Investigational Site
Haskovo, Bulgaria, 6300
GSK Investigational Site
Pleven, Bulgaria, 5800
GSK Investigational Site
Plovdiv, Bulgaria, 4002
GSK Investigational Site
Plovdiv, Bulgaria, 4003
GSK Investigational Site
Sofia, Bulgaria, 1202
GSK Investigational Site
Sofia, Bulgaria, 1709
GSK Investigational Site
Sofia, Bulgaria, 1527
GSK Investigational Site
Sofia, Bulgaria, 1407
GSK Investigational Site
Sofia, Bulgaria, 1606
GSK Investigational Site
Sofia, Bulgaria, 1000
GSK Investigational Site
Veliko Tarnovo, Bulgaria, 5000
Canada, Alberta
GSK Investigational Site
Edmonton, Alberta, Canada, T6G 2B7
Canada, British Columbia
GSK Investigational Site
Campbell River, British Columbia, Canada, V9W 5Y4
GSK Investigational Site
New Westminister, British Columbia, Canada, V3L 3W4
GSK Investigational Site
Surrey, British Columbia, Canada, V3V 1N1
GSK Investigational Site
Vancouver, British Columbia, Canada, V5Z 1M9
GSK Investigational Site
Victoria, British Columbia, Canada, V8R 4R2
Canada, Newfoundland and Labrador
GSK Investigational Site
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
GSK Investigational Site
Truro, Nova Scotia, Canada, B2N 1L2
Canada, Ontario
GSK Investigational Site
Ajax, Ontario, Canada, L1S 7K8
GSK Investigational Site
Brampton, Ontario, Canada, L6Z 4N5
GSK Investigational Site
Cambridge, Ontario, Canada, N1R 6V6
GSK Investigational Site
Cambridge, Ontario, Canada, N1R 7R1
GSK Investigational Site
Hamilton, Ontario, Canada, L8L 2X2
GSK Investigational Site
Kelowna, Ontario, Canada, V1Y 1E4
GSK Investigational Site
Mississauga, Ontario, Canada, L5B 2P7
GSK Investigational Site
Newmarket, Ontario, Canada, L3Y 8C3
GSK Investigational Site
Oshawa, Ontario, Canada, L1J 2J9
GSK Investigational Site
Oshawa, Ontario, Canada, L1J 2K1
GSK Investigational Site
Ottawa, Ontario, Canada, K1Y 4W7
GSK Investigational Site
Sarnia, Ontario, Canada, N7T 4X3
GSK Investigational Site
Sudbury, Ontario, Canada, P3E 3B8
GSK Investigational Site
Sudbury, Ontario, Canada, P3C 1S8
GSK Investigational Site
Thunder Bay, Ontario, Canada, P7B 7C7
GSK Investigational Site
Toronto, Ontario, Canada, M4C 3E7
GSK Investigational Site
Toronto, Ontario, Canada, M5C 2T2
Canada, Quebec
GSK Investigational Site
Greenfield Park, Quebec, Canada, JAV 2GB
GSK Investigational Site
Longueuil, Quebec, Canada, J4M 2X1
GSK Investigational Site
Montreal, Quebec, Canada, H1T 3Y7
GSK Investigational Site
Montreal, Quebec, Canada, H3G 1A4
GSK Investigational Site
Sherbrooke, Quebec, Canada, J1H 5N4
GSK Investigational Site
Thetford Mines, Quebec, Canada, G6G 2V4
Chile
GSK Investigational Site
Temuco, Región De La Araucania, Chile
GSK Investigational Site
Concepción, Región Del Biobio, Chile, 56-41
GSK Investigational Site
Talcahuano, Región Del Biobio, Chile, 427 0918
GSK Investigational Site
Santiago, Región Metro De Santiago, Chile, 7650018
GSK Investigational Site
Santiago, Región Metro De Santiago, Chile, 8330024
GSK Investigational Site
Santiago, Región Metro De Santiago, Chile, 750 0922
GSK Investigational Site
Viña del Mar, Valparaíso, Chile
GSK Investigational Site
Santiago, Chile, 8900085
GSK Investigational Site
Santiago, Chile, 8207257
GSK Investigational Site
Temuco, Chile
China, Gansu
GSK Investigational Site
Lanzhou, Gansu, China, 730030
China, Guangdong
GSK Investigational Site
Guangzhou, Guangdong, China, 510080
GSK Investigational Site
Guangzhou, Guangdong, China, 510120
China, Guangxi
GSK Investigational Site
Nanning, Guangxi, China, 530021
China, Hainan
GSK Investigational Site
Haikou, Hainan, China, 570102
China, Hebei
GSK Investigational Site
Shijiazhuang, Hebei, China, 050000
China, Jiangsu
GSK Investigational Site
Nanjing, Jiangsu, China, 210029
China, Liaoning
GSK Investigational Site
Dalian, Liaoning, China, 116027
GSK Investigational Site
Shenyang, Liaoning, China, 110004
GSK Investigational Site
Shenyang, Liaoning, China, 110016
China, Shaanxi
GSK Investigational Site
Xian, Shaanxi, China, 710061
China, Shandong
GSK Investigational Site
Jinan, Shandong, China, 250033
China, Sichuan
GSK Investigational Site
Chengdu, Sichuan, China, 610041
China, Zhejiang
GSK Investigational Site
Hangzhou, Zhejiang, China, 310009
China
GSK Investigational Site
Beijing, China, 100037
GSK Investigational Site
Beijing, China, 100020
GSK Investigational Site
Beijing, China, 100029
GSK Investigational Site
Beijing, China, 100730
GSK Investigational Site
Beijing, China, 100050
GSK Investigational Site
Beijing, China, 100853
GSK Investigational Site
Hangzhou, China, 310016
GSK Investigational Site
Jinan, China, 250012
GSK Investigational Site
Shanghai, China, 200003
GSK Investigational Site
Shanghai, China, 200040
GSK Investigational Site
Shanghai, China, 200065
GSK Investigational Site
Suzhou, China, 215004
Colombia
GSK Investigational Site
Armenia, Colombia
GSK Investigational Site
Barranquilla, Colombia
GSK Investigational Site
Bogota, Colombia, 38007
GSK Investigational Site
Bogota, Colombia, 5600520
GSK Investigational Site
Bogota, Colombia
GSK Investigational Site
Bogotá, Colombia
GSK Investigational Site
Bucaramanga, Colombia
GSK Investigational Site
Cartagena, Colombia
GSK Investigational Site
Manizales, Colombia
GSK Investigational Site
Medellin, Colombia
GSK Investigational Site
Medellín, Colombia
Czech Republic
GSK Investigational Site
Brno, Czech Republic, 625 00
GSK Investigational Site
Brno, Czech Republic, 656 91
GSK Investigational Site
Brno, Czech Republic, 656 91
GSK Investigational Site
Caslav, Czech Republic, 286 01
GSK Investigational Site
Jihlava, Czech Republic, 586 33
GSK Investigational Site
Kromeriz, Czech Republic, 767 55
GSK Investigational Site
Milevsko, Czech Republic, 399 01
GSK Investigational Site
Olomouc, Czech Republic, 775 20
GSK Investigational Site
Plzen - Bory, Czech Republic, 305 99
GSK Investigational Site
Praha 10, Czech Republic, 100 34
GSK Investigational Site
Praha 2, Czech Republic, 128 08
GSK Investigational Site
Slany, Czech Republic
GSK Investigational Site
Svitavy, Czech Republic, 568 25
GSK Investigational Site
Usti nad Orlici, Czech Republic, 562 18
GSK Investigational Site
Zlin, Czech Republic, 762 75
Denmark
GSK Investigational Site
Aalborg, Denmark, DK-9000
GSK Investigational Site
Aarhus, Denmark, DK-8000
GSK Investigational Site
Esbjerg, Denmark, 6700
GSK Investigational Site
Frederikssund, Denmark, DK-3600
GSK Investigational Site
Glostrup, Denmark, DK-2600
GSK Investigational Site
Hellerup, Denmark, 2900
GSK Investigational Site
Herlev, Denmark, DK-2730
GSK Investigational Site
Holbæk, Denmark, DK-4300
GSK Investigational Site
Hvidovre, Denmark, DK-2650
GSK Investigational Site
Koebenhavn N, Denmark, 2100
GSK Investigational Site
Kolding, Denmark, DK-6000
GSK Investigational Site
København NV, Denmark, DK-2400
GSK Investigational Site
København S, Denmark, DK-2300
GSK Investigational Site
Køge, Denmark, DK-4600
GSK Investigational Site
Næstved, Denmark, 4700
GSK Investigational Site
Odense C, Denmark, DK-5000
GSK Investigational Site
Roskilde, Denmark, 4000
GSK Investigational Site
Silkeborg, Denmark, DK-8600
GSK Investigational Site
Svendborg, Denmark, 5700
France
GSK Investigational Site
Pau, Aquitaine, France, 64046
GSK Investigational Site
Langres, Champagne-Ardenne, France, 52206
GSK Investigational Site
Dunkerque, Nord-Pas-de-Calais, France, 59240
GSK Investigational Site
Avignon, France, 84000
GSK Investigational Site
Besançon Cedex, France, 25030
GSK Investigational Site
Bron, France, 69677
GSK Investigational Site
Créteil, France, 94010
GSK Investigational Site
Dijon Cedex, France, 21079
GSK Investigational Site
Lagny sur Marne, France, 77405
GSK Investigational Site
Le Plessis Robinson, France, 92350
GSK Investigational Site
Lille, France, 59000
GSK Investigational Site
Marseille Cedex 08, France, 13285
GSK Investigational Site
Montfermeil, France, 93370
GSK Investigational Site
Paris, France, 75651
GSK Investigational Site
Paris Cedex 18, France, 75877
GSK Investigational Site
Poitiers, France, 86021
GSK Investigational Site
Quincy sous Sénart, France, 91480
GSK Investigational Site
Rennes, France, 35033
GSK Investigational Site
Strasbourg Cedex, France, 67091
GSK Investigational Site
Toulouse, France, 31500
GSK Investigational Site
Tourcoing, France, 59200
GSK Investigational Site
Valenciennes, France, 59300
Germany
GSK Investigational Site
Bad Krozingen, Baden-Wuerttemberg, Germany, 79189
GSK Investigational Site
Freiburg, Baden-Wuerttemberg, Germany, 79106
GSK Investigational Site
Heidelberg, Baden-Wuerttemberg, Germany, 69120
GSK Investigational Site
Stuttgart, Baden-Wuerttemberg, Germany, 70376
GSK Investigational Site
Ulm, Baden-Wuerttemberg, Germany, 89081
GSK Investigational Site
Muenchen, Bayern, Germany, 81737
GSK Investigational Site
Muenchen, Bayern, Germany, 80336
GSK Investigational Site
Bad Nauheim, Hessen, Germany, 61231
GSK Investigational Site
Darmstadt, Hessen, Germany, 64283
GSK Investigational Site
Frankfurt, Hessen, Germany, 65929
GSK Investigational Site
Frankfurt, Hessen, Germany, 60590
GSK Investigational Site
Langen, Hessen, Germany, 63225
GSK Investigational Site
Limburg, Hessen, Germany, 65549
GSK Investigational Site
Bad Rothenfelde, Niedersachsen, Germany, 49214
GSK Investigational Site
Hannover, Niedersachsen, Germany, 30625
GSK Investigational Site
Oldenburg, Niedersachsen, Germany, 26133
GSK Investigational Site
Bielefeld, Nordrhein-Westfalen, Germany, 33604
GSK Investigational Site
Eschweiler, Nordrhein-Westfalen, Germany, 52249
GSK Investigational Site
Essen, Nordrhein-Westfalen, Germany, 45122
GSK Investigational Site
Essen, Nordrhein-Westfalen, Germany, 45359
GSK Investigational Site
Neuss, Nordrhein-Westfalen, Germany, 41464
GSK Investigational Site
Wuppertal, Nordrhein-Westfalen, Germany, 42117
GSK Investigational Site
Ludwigshafen, Rheinland-Pfalz, Germany, 67063
GSK Investigational Site
Homburg, Saarland, Germany, 66421
GSK Investigational Site
Kiel, Schleswig-Holstein, Germany, 24105
GSK Investigational Site
Luebeck, Schleswig-Holstein, Germany, 23538
GSK Investigational Site
Altenburg, Thueringen, Germany, 04600
GSK Investigational Site
Berlin, Germany, 12351
GSK Investigational Site
Berlin, Germany, 13353
GSK Investigational Site
Berlin, Germany, 12559
GSK Investigational Site
Bremen, Germany, 28277
GSK Investigational Site
Halle, Germany, 06120
GSK Investigational Site
Hamburg, Germany, 20246
Hungary
GSK Investigational Site
Budapest, Hungary, 1032
GSK Investigational Site
Budapest, Hungary, 1125
GSK Investigational Site
Budapest, Hungary, 1122
GSK Investigational Site
Budapest, Hungary, 1145
GSK Investigational Site
Budapest, Hungary, 1106
GSK Investigational Site
Budapest, Hungary, 1096
GSK Investigational Site
Budapest, Hungary, 1134
GSK Investigational Site
Cegléd, Hungary, 2700
GSK Investigational Site
Eger, Hungary, 3300
GSK Investigational Site
Gyula, Hungary, 5700
GSK Investigational Site
Hodmezovasarhely, Hungary, 6800
GSK Investigational Site
Kistarcsa, Hungary, 2143
GSK Investigational Site
Miskolc, Hungary, 3526
GSK Investigational Site
Szolnok, Hungary, 5004
GSK Investigational Site
Szombathely, Hungary, 9700
GSK Investigational Site
Székesfehérvár, Hungary, 8000
GSK Investigational Site
Zalaegerszeg, Hungary, 8900
India
GSK Investigational Site
Ahmedabad, India, 380052
GSK Investigational Site
Ahmedabad, India, 380060
GSK Investigational Site
Amritsar, India, 143004
GSK Investigational Site
Chennai, India, 600037
GSK Investigational Site
Chennai, India, 600081
GSK Investigational Site
Faridabad, India, 121001
GSK Investigational Site
Gandhinagar, India, 382428
GSK Investigational Site
Gurgaon, India, 122001
GSK Investigational Site
Hyderabad, India, 500001
GSK Investigational Site
Hyderabad, India, 500020
GSK Investigational Site
Hyderabad, India, 500033
GSK Investigational Site
Hyderabad, India, 500082
GSK Investigational Site
Hyderabad, India, 500063
GSK Investigational Site
Indore, India, 452018
GSK Investigational Site
Jaipur, India, 302017
GSK Investigational Site
Lucknow, India, 226014
GSK Investigational Site
Mohali, India, 160062
GSK Investigational Site
New Delhi, India, 110060
GSK Investigational Site
New Delhi, India, 110070
GSK Investigational Site
New Delhi, India, 110025
GSK Investigational Site
Noida, India, 201301
GSK Investigational Site
Patiala, India, 147001
GSK Investigational Site
Pune, India, 411004
GSK Investigational Site
Pune,, India, 411001
GSK Investigational Site
Secunderabad,, India, 500003
GSK Investigational Site
Vadodara, India, 390015
GSK Investigational Site
Visakhapatnam, India, 530002
Israel
GSK Investigational Site
Ashkelon, Israel, 78278
GSK Investigational Site
Beer Sheva, Israel, 84350
GSK Investigational Site
Haddera, Israel, 38100
GSK Investigational Site
Haifa, Israel, 31048
GSK Investigational Site
Haifa, Israel, 34362
GSK Investigational Site
Haifa, Israel, 31096
GSK Investigational Site
Holon, Israel, 58100
GSK Investigational Site
Jerusalem, Israel, 91031
GSK Investigational Site
Jerusalem, Israel, 91004
GSK Investigational Site
Jerusalem, Israel, 91120
GSK Investigational Site
Jerusalem, Israel, 91240
GSK Investigational Site
Kfar Saba, Israel, 44281
GSK Investigational Site
Nahariya, Israel, 22100
GSK Investigational Site
Poriya, Israel, 15208
GSK Investigational Site
Raanana, Israel, 43000
GSK Investigational Site
Ramat-Gan, Israel, 52621
GSK Investigational Site
Rehovot, Israel, 76100
GSK Investigational Site
Safed, Israel, 13110
GSK Investigational Site
Tel Aviv, Israel, 64239
Italy
GSK Investigational Site
Catanzaro, Calabria, Italy, 88100
GSK Investigational Site
Napoli, Campania, Italy, 80131
GSK Investigational Site
Bologna, Emilia-Romagna, Italy, 40138
GSK Investigational Site
Carpi, Emilia-Romagna, Italy, 41012
GSK Investigational Site
Ferrara, Emilia-Romagna, Italy, 44100
GSK Investigational Site
Parma, Emilia-Romagna, Italy, 43100
GSK Investigational Site
Palmanova, Friuli-Venezia-Giulia, Italy, 33057
GSK Investigational Site
San Daniele del Friuli, Friuli-Venezia-Giulia, Italy, 33038
GSK Investigational Site
Udine, Friuli-Venezia-Giulia, Italy, 33100
GSK Investigational Site
Roma, Lazio, Italy, 00135
GSK Investigational Site
Roma, Lazio, Italy, 00168
GSK Investigational Site
Roma, Lazio, Italy, 00189
GSK Investigational Site
Bergamo, Lombardia, Italy, 24128
GSK Investigational Site
Milano, Lombardia, Italy, 20162
GSK Investigational Site
Rozzano (Mi), Lombardia, Italy, 20089
GSK Investigational Site
Ascoli Piceno, Marche, Italy, 63100
GSK Investigational Site
Novara, Piemonte, Italy, 28100
GSK Investigational Site
Sassari, Sardegna, Italy, 07100
GSK Investigational Site
Pisa, Toscana, Italy, 56126
GSK Investigational Site
Treviso, Veneto, Italy, 31100
GSK Investigational Site
Legnano, Italy, 20025
GSK Investigational Site
Sassuolo, Italy, 41049
Japan
GSK Investigational Site
Chiba, Japan, 270-2251
GSK Investigational Site
Fukuoka, Japan, 811-0213
GSK Investigational Site
Fukuoka, Japan, 807-0051
GSK Investigational Site
Fukuoka, Japan, 816-0864
GSK Investigational Site
Hokkaido, Japan, 006-8555
GSK Investigational Site
Hokkaido, Japan, 063-0005
GSK Investigational Site
Hokkaido, Japan, 065-0033
GSK Investigational Site
Hyogo, Japan, 650-0047
GSK Investigational Site
Kanagawa, Japan, 243-8551
GSK Investigational Site
Kanagawa, Japan, 247-8533
GSK Investigational Site
Kanagawa, Japan, 232-0024
GSK Investigational Site
Kyoto, Japan, 606-8507
GSK Investigational Site
Nagasaki, Japan, 856-8562
GSK Investigational Site
Oita, Japan, 870-0263
GSK Investigational Site
Okayama, Japan, 700-8558
GSK Investigational Site
Osaka, Japan, 574-0074
GSK Investigational Site
Osaka, Japan, 580-0032
GSK Investigational Site
Osaka, Japan, 565-8565
GSK Investigational Site
Saga, Japan, 843-0393
GSK Investigational Site
Shizuoka, Japan, 410-2295
GSK Investigational Site
Tokyo, Japan, 160-8582
GSK Investigational Site
Tokyo, Japan, 196-0003
GSK Investigational Site
Tokyo, Japan, 113-8431
GSK Investigational Site
Tokyo, Japan, 101-8643
Korea, Republic of
GSK Investigational Site
Dae-Gu, Korea, Republic of, 700-721
GSK Investigational Site
Daejeon, Korea, Republic of, 301721
GSK Investigational Site
Gangnam-gu, Seoul, Korea, Republic of, 135-710
GSK Investigational Site
Gwangju, Korea, Republic of, 501-757
GSK Investigational Site
Kangwon-do, Korea, Republic of, 220-701
GSK Investigational Site
Pusan, Korea, Republic of, 602-739
GSK Investigational Site
Seoul, Korea, Republic of, 110-744
GSK Investigational Site
Seoul, Korea, Republic of, 137-701
GSK Investigational Site
Seoul, Korea, Republic of, 120-752
GSK Investigational Site
Seoul, Korea, Republic of, 138-736
Netherlands
GSK Investigational Site
's-Hertogenbosch, Netherlands, 5223 GZ
GSK Investigational Site
Amersfoort, Netherlands, 3818 ES
GSK Investigational Site
Amsterdam, Netherlands, 1091 AC
GSK Investigational Site
Amsterdam, Netherlands, 1105 AZ
GSK Investigational Site
Amsterdam, Netherlands, 1061 AE
GSK Investigational Site
Apeldoorn, Netherlands, 7334 DZ
GSK Investigational Site
Blaricum, Netherlands, 1261 AN
GSK Investigational Site
Den Haag, Netherlands, 2597 AX
GSK Investigational Site
Deventer, Netherlands, 7416 SE
GSK Investigational Site
Dirksland, Netherlands, 3247 BW
GSK Investigational Site
Doetinchem, Netherlands, 7009 BL
GSK Investigational Site
Drachten, Netherlands, 9202 NN
GSK Investigational Site
Eindhoven, Netherlands, 5623 EJ
GSK Investigational Site
Gorinchem, Netherlands, 4204 AA
GSK Investigational Site
Gouda, Netherlands, 2803 HH
GSK Investigational Site
Groningen, Netherlands, 9728 NT
GSK Investigational Site
Hardenberg, Netherlands, 7772 SE
GSK Investigational Site
Harderwijk, Netherlands, 3844 DG
GSK Investigational Site
Heerenveen, Netherlands, 8441 PW
GSK Investigational Site
Heerlen, Netherlands, 6419 PC
GSK Investigational Site
Helmond, Netherlands, 5707 HA
GSK Investigational Site
Hilversum, Netherlands, 1213 XZ
GSK Investigational Site
Hoofddorp, Netherlands, 2134 TM
GSK Investigational Site
Hoorn, Netherlands, 1625 HV
GSK Investigational Site
Nijmegen, Netherlands, 6532 SZ
GSK Investigational Site
OSS, Netherlands, 5342 BT
GSK Investigational Site
Roermond, Netherlands, 6043 CV
GSK Investigational Site
Rotterdam, Netherlands, 3045 PM
GSK Investigational Site
Rotterdam, Netherlands, 3083 AN
GSK Investigational Site
Sittard-geleen, Netherlands, 6162 BG
GSK Investigational Site
Sneek, Netherlands, 8601 ZR
GSK Investigational Site
Tiel, Netherlands, 4002 WP
GSK Investigational Site
Tilburg, Netherlands, 5042AD
GSK Investigational Site
Veldhoven, Netherlands, 5504 DB
GSK Investigational Site
Venlo, Netherlands, 5912 BL
GSK Investigational Site
Zoetermeer, Netherlands, 2725 NA
New Zealand
GSK Investigational Site
Auckland, New Zealand
GSK Investigational Site
Auckland, New Zealand, 2025
GSK Investigational Site
Christchurch, New Zealand
GSK Investigational Site
Dunedin, New Zealand
GSK Investigational Site
Hamilton, New Zealand, 3204
GSK Investigational Site
Lower Hutt, New Zealand, 6007
GSK Investigational Site
New Plymouth, New Zealand, 4310
GSK Investigational Site
Palmerston North, New Zealand
GSK Investigational Site
Takapuna, Auckland, New Zealand, 0622
GSK Investigational Site
Tauranga, New Zealand
GSK Investigational Site
Whangarei, New Zealand
Peru
GSK Investigational Site
Miraflores, Lima, Lima, Peru, Lima 18
GSK Investigational Site
San Martin de Porres, Lima, Peru, Lima 31
GSK Investigational Site
Callao, Peru, Callao 02
GSK Investigational Site
Lima, Peru, Lima 11
GSK Investigational Site
Lima, Peru, Lima 27
GSK Investigational Site
Lima, Peru, Lima 33
GSK Investigational Site
Lima Cercado, Peru, LIMA 01
Philippines
GSK Investigational Site
Cebu City, Philippines, 6000
GSK Investigational Site
Davao, Philippines, 8000
GSK Investigational Site
Manila, Philippines, 1000
GSK Investigational Site
Quezon City, Philippines, 1100
GSK Investigational Site
Quezon City, Philippines, 1109
GSK Investigational Site
Quezon City, Philippines, 1113
Poland
GSK Investigational Site
Bialystok, Poland, 15-276
GSK Investigational Site
Bydgoszcz, Poland, 85-079
GSK Investigational Site
Bytom, Poland, 41-902
GSK Investigational Site
Chrzanow, Poland, 32-500
GSK Investigational Site
Gdansk, Poland, 80-952
GSK Investigational Site
Gdynia, Poland, 81-423
GSK Investigational Site
Gdynia, Poland, 81-472
GSK Investigational Site
Gdynia, Poland, 81-519
GSK Investigational Site
Inowroclaw, Poland
GSK Investigational Site
Krakow, Poland, 31-202
GSK Investigational Site
Krakow, Poland, 31-121
GSK Investigational Site
Lodz, Poland, 91-347
GSK Investigational Site
Lubin, Poland, 59-300
GSK Investigational Site
Mielec, Poland, 39-300
GSK Investigational Site
Olawa, Poland, 55-200
GSK Investigational Site
Opole, Poland, 45-418
GSK Investigational Site
Radom, Poland, 26-617
GSK Investigational Site
Skierniewice, Poland, 96-100
GSK Investigational Site
Tarnow, Poland, 33-100
GSK Investigational Site
Torun, Poland, 87-100
GSK Investigational Site
Tychy, Poland, 43-100
GSK Investigational Site
Walbrzych, Poland, 58-309
GSK Investigational Site
Warsaw, Poland, 02-507
GSK Investigational Site
Warszawa, Poland, 02-637
GSK Investigational Site
Warszawa, Poland, 04-073
GSK Investigational Site
Warszawa, Poland, 00-685
GSK Investigational Site
Wloclawek, Poland, 87-800
GSK Investigational Site
Wroclaw, Poland, 51-124
GSK Investigational Site
Wroclaw, Poland, 50-349
GSK Investigational Site
Wroclaw, Poland, 50-367
GSK Investigational Site
Zamosc, Poland, 22-400
GSK Investigational Site
Zielona Gora, Poland, 65-046
Romania
GSK Investigational Site
Baia Mare, Romania, 430123
GSK Investigational Site
Braila, Romania, 810249
GSK Investigational Site
Brasov, Romania, 500326
GSK Investigational Site
Bucharest, Romania, 011794
GSK Investigational Site
Bucharest, Romania, 041915
GSK Investigational Site
Bucharest, Romania, 011461
GSK Investigational Site
Bucharest, Romania, 014461
GSK Investigational Site
Bucharest, Romania, 022328
GSK Investigational Site
Bucharest, Romania, 050098
GSK Investigational Site
Cluj-Napoca, Romania, 400001
GSK Investigational Site
Constanta, Romania, 900591
GSK Investigational Site
Craiova, Romania, 200642
GSK Investigational Site
Iasi, Romania, 700503
GSK Investigational Site
Targu Mures, Romania, 540136
Russian Federation
GSK Investigational Site
Barnaul, Russian Federation, 656024
GSK Investigational Site
Ekaterinburg, Russian Federation, 620039
GSK Investigational Site
Ekaterinburg, Russian Federation, 620109
GSK Investigational Site
Gatchina, Russian Federation, 188300
GSK Investigational Site
Kemerovo, Russian Federation, 650036
GSK Investigational Site
Kemerovo, Russian Federation, 650002
GSK Investigational Site
Krasnoyarsk, Russian Federation, 660097
GSK Investigational Site
Moscow, Russian Federation, 121552
GSK Investigational Site
Moscow, Russian Federation, 117292
GSK Investigational Site
Moscow, Russian Federation, 127473
GSK Investigational Site
Moscow, Russian Federation, 127018
GSK Investigational Site
Moscow, Russian Federation, 121 309
GSK Investigational Site
Moscow, Russian Federation, 105187
GSK Investigational Site
Moscow, Russian Federation, 111539
GSK Investigational Site
Moscow, Russian Federation, 119620
GSK Investigational Site
Moscow, Russian Federation, 111020
GSK Investigational Site
Moscow, Russian Federation, 119991
GSK Investigational Site
Nizhniy Novgorod, Russian Federation, 603035
GSK Investigational Site
Nizhniy Novgorod, Russian Federation, 603076
GSK Investigational Site
Novosibirsk, Russian Federation, 630047
GSK Investigational Site
Novosibirsk, Russian Federation, 630008
GSK Investigational Site
Orenburg, Russian Federation, 460040
GSK Investigational Site
Samara, Russian Federation, 443070
GSK Investigational Site
Saratov, Russian Federation, 410054
GSK Investigational Site
Saratov, Russian Federation, 410028
GSK Investigational Site
St'Petersburg, Russian Federation, 194156
GSK Investigational Site
St-Petersburg, Russian Federation, 193312
GSK Investigational Site
St-Petersburg, Russian Federation, 199106
GSK Investigational Site
St-Petersburg, Russian Federation, 195067
GSK Investigational Site
St. Petersburg, Russian Federation, 196247
GSK Investigational Site
St. Petersburg, Russian Federation, 190000
GSK Investigational Site
St. Petersburg, Russian Federation, 198013
GSK Investigational Site
St. Petersburg, Russian Federation, 198205
GSK Investigational Site
St. Petersburg, Russian Federation, 196601
GSK Investigational Site
St. Petersburg, Russian Federation, 192242
GSK Investigational Site
St. Petersburg, Russian Federation, 193079
GSK Investigational Site
Tomsk, Russian Federation, 643012
GSK Investigational Site
Tyumen, Russian Federation, 625023
GSK Investigational Site
Tyumen, Russian Federation, 625026
GSK Investigational Site
Yaroslavl, Russian Federation, 150003
Slovakia
GSK Investigational Site
Bratislava, Slovakia, 833 48
GSK Investigational Site
Bratislava, Slovakia, 826 06
GSK Investigational Site
Bratislava, Slovakia, 813 69
GSK Investigational Site
Bratislava, Slovakia, 833 05
GSK Investigational Site
Kosice, Slovakia, 040 22
GSK Investigational Site
Nitra, Slovakia, 950 01
GSK Investigational Site
Nitra, Slovakia, 949 01
GSK Investigational Site
Nove Zamky, Slovakia, 940 52
South Africa
GSK Investigational Site
Bloemfontein, Free State, South Africa, 9301
GSK Investigational Site
Alberton, Gauteng, South Africa, 1449
GSK Investigational Site
Johannesburg, Gauteng, South Africa, 2000
GSK Investigational Site
Pretoria, Gauteng, South Africa, 0132
GSK Investigational Site
Pretoria, Gauteng, South Africa, 0001
GSK Investigational Site
Durban, KwaZulu- Natal, South Africa, 4001
GSK Investigational Site
Durban, KwaZulu- Natal, South Africa, 4052
GSK Investigational Site
Cape Town, Western Province, South Africa, 7500
GSK Investigational Site
Cape Town, Western Province, South Africa, 7530
GSK Investigational Site
Panorama, Western Province, South Africa, 7500
GSK Investigational Site
Goodwood, South Africa, 7460
GSK Investigational Site
Kempton Park, South Africa, 1619
GSK Investigational Site
Paarl, South Africa, 7646
GSK Investigational Site
Parktown West, South Africa, 2193
GSK Investigational Site
Parow, South Africa, 7505
GSK Investigational Site
Pretoria, South Africa, 0041
GSK Investigational Site
Pretoria, South Africa, 0002
GSK Investigational Site
Somerset West, South Africa, 7130
GSK Investigational Site
Worcester, South Africa, 6850
Spain
GSK Investigational Site
Alicante, Spain, 03010
GSK Investigational Site
Barcelona, Spain, 08035
GSK Investigational Site
Lerida, Spain, 25198
GSK Investigational Site
León, Spain, 24071
GSK Investigational Site
Madrid, Spain, 28006
GSK Investigational Site
Madrid, Spain, 28046
GSK Investigational Site
Malaga, Spain, 29010
GSK Investigational Site
Oviedo, Spain, 33006
GSK Investigational Site
San Juan/Alicante, Spain, 03550
GSK Investigational Site
San Sebastián, Spain, 20014
GSK Investigational Site
San Sebastián de los Reyes/Madrid, Spain
GSK Investigational Site
Sevilla, Spain, 41009
GSK Investigational Site
Valencia, Spain, 46014
GSK Investigational Site
Vigo/Pontevedra, Spain, 36200
Sweden
GSK Investigational Site
Göteborg, Sweden, SE-41685
GSK Investigational Site
Göteborg, Sweden, SE-43180
GSK Investigational Site
Göteborg, Sweden, SE-413 45
GSK Investigational Site
Hässleholm, Sweden, SE-28125
GSK Investigational Site
Jönköping, Sweden, SE-551 85
GSK Investigational Site
Stockholm, Sweden, SE-11883
GSK Investigational Site
Västerås, Sweden, SE-721 89
GSK Investigational Site
Örebro, Sweden, SE-70185
GSK Investigational Site
Östersund, Sweden, SE-831 83
Taiwan
GSK Investigational Site
Kaohsiung, Taiwan, 833
GSK Investigational Site
Kaohsiung City, Taiwan, 807
GSK Investigational Site
Taipei, Taiwan, 220
GSK Investigational Site
Taipei, Taiwan, 111
GSK Investigational Site
Taipei, Taiwan, 112
GSK Investigational Site
Yung Kang City, Taiwan, 71044
Thailand
GSK Investigational Site
Bangkok, Thailand, 10400
GSK Investigational Site
Bangkoknoi, Thailand, 10700
GSK Investigational Site
Chiangmai, Thailand, 50200
GSK Investigational Site
Khon Kaen, Muang, Thailand, 40002
GSK Investigational Site
Nakhon Ratchasima, Thailand, 30000
GSK Investigational Site
Pathumthani, Thailand, 12120
Turkey
GSK Investigational Site
Ankara, Turkey, 06500
GSK Investigational Site
Erzurum, Turkey, 25240
GSK Investigational Site
Eskisehir, Turkey, 26480
GSK Investigational Site
Izmir, Turkey, 35360
GSK Investigational Site
Izmir, Turkey, 35340
GSK Investigational Site
Izmir, Turkey, 35100
Ukraine
GSK Investigational Site
Dnipropetrovsk, Ukraine, 49006
GSK Investigational Site
Donetsk, Ukraine, 83114
GSK Investigational Site
Kharkiv, Ukraine, 61002
GSK Investigational Site
Kharkiv, Ukraine, 61176
GSK Investigational Site
Kharkiv, Ukraine, 61018
GSK Investigational Site
Kharkiv, Ukraine, 61039
GSK Investigational Site
Kyiv, Ukraine, 03680
GSK Investigational Site
Kyiv, Ukraine, 03049
GSK Investigational Site
Kyiv, Ukraine, 02660
GSK Investigational Site
Kyiv, Ukraine, 3115
GSK Investigational Site
Kyiv, Ukraine, 01601
GSK Investigational Site
Kyiv, Ukraine, 02091
GSK Investigational Site
Lugansk, Ukraine, 91045
GSK Investigational Site
Lutsk, Ukraine, 43024
GSK Investigational Site
Mykolaiv, Ukraine, 54033
GSK Investigational Site
Odesa, Ukraine, 65014
GSK Investigational Site
Simferopol, Ukraine, 95026
GSK Investigational Site
Vinnytsia, Ukraine, 21018
GSK Investigational Site
Vinnytsia, Ukraine, 21029
GSK Investigational Site
Zaporizhzhya, Ukraine, 69000
United Kingdom
GSK Investigational Site
Exeter, Devon, United Kingdom, EX2 5DW
GSK Investigational Site
Torquay, Devon, United Kingdom, TQ2 7AA
GSK Investigational Site
Airdrie, Lanarkshire, United Kingdom, ML6 0JS
GSK Investigational Site
Harrow, Middlesex, United Kingdom, HA1 3UJ
GSK Investigational Site
Northampton, Northamptonshire, United Kingdom, NN1 5BD
GSK Investigational Site
Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
GSK Investigational Site
Chertsey, Surrey, United Kingdom, KT16 0PZ
GSK Investigational Site
Coventry, West Midlands, United Kingdom, CV2 2DX
GSK Investigational Site
Antrim, United Kingdom, BT41 2RL
GSK Investigational Site
Chichester, United Kingdom, PO19 6SE
GSK Investigational Site
East Kilbride, United Kingdom, G75 8RG
GSK Investigational Site
Hertfordshire, United Kingdom
GSK Investigational Site
Liverpool, United Kingdom, L7 8XP
GSK Investigational Site
Paisley, United Kingdom, PA2 9PN
GSK Investigational Site
Stirling, United Kingdom, FK8 2AU
Sponsors and Collaborators
GlaxoSmithKline
The TIMI Study Group
Investigators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

No publications provided by GlaxoSmithKline

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT01000727     History of Changes
Other Study ID Numbers: 480848/033
Study First Received: October 22, 2009
Last Updated: October 23, 2014
Health Authority: Spain: Agencia Espanola de Medicamentos y Productos Sanitarios
Slovakia: State Institute for Drug Control
Estonia: State Agency of Medicines
Colombia: INVIMA
Chile: Institutional Review Board
Brazil: Institutional Review Board
Peru: Institutional Review Board
Greece: National Ethics Committee
United Kingdom: Medicines and Healthcare Products Regulatory Agency
Italy: Comitato Etico Unico per la Provincia di Parma - Via Gramsci, 14- 43100 Parma
Belgium: Federal Agency for Medicinal Products and Health Products
Bulgaria: The Bulgarian Drug Agency
Argentina: Ministry of Health - A.N.M.A.T
Romania: Agentia Nationala a Medicamentului
Ukraine: The Central Ethics Committee of Ministry of Health of Ukraine
Japan: Pharmaceutical and Medical Device Agency
Russia: Federal Service of Surveillance in Healthcare and Social development of Russian federation
Norway: Statens Legemiddelverk
Taiwan: Department of Health
India: Drugs Controller General of India
Thailand: Ministry of Public Health
Philippines: Bureau of Food and Drugs
Hungary: Országos Gyógyszerészeti Intézet
South Africa: Medicines Control Council
Poland: URZ.D REJESTRACJI PRODUKTÓW LECZNICZYCH, WYROBÓW MEDYCZNYCH I PRODUKTÓW BIOBÓJCZYCH,CEBK
Mexico: Ministry of Health
New Zealand: Medicines and Medical Devices Safety Authority
Denmark: Danish Medicines Agency
France: Agence Française de Sécurité Sanitaire des Produits de Santé
Germany: Federal Institute for Drugs and Medical Devices
Netherlands: De Centrale Commissie Mensgebonden Onderzoek
Israel: Ministry of Health
Czech: State Institute for Drug Control
China: Food and Drug Administration
South Korea: Food and Drug Administration
United States: Food and Drug Administration
Sweden: Läkemedelsverket
Turkey: Ministry of Health
Australia: Therapeutic Goods Administration
Greece: National Drug Organisation

Keywords provided by GlaxoSmithKline:
Cardiovascular disease
Atherosclerosis
Coronary Heart Disease (CHD)
Heart disease
Lp-PLA2 inhibitor
The TIMI Study Group
Acute Coronary Syndrome (ACS)

Additional relevant MeSH terms:
Acute Coronary Syndrome
Syndrome
Angina Pectoris
Cardiovascular Diseases
Chest Pain
Disease
Heart Diseases
Myocardial Ischemia
Pain
Pathologic Processes
Signs and Symptoms
Vascular Diseases
Darapladib
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Phospholipase A2 Inhibitors

ClinicalTrials.gov processed this record on November 27, 2014