S0800, Nab-Paclitaxel, Doxorubicin, Cyclophosphamide, and Pegfilgrastim With or Without Bevacizumab in Treating Women With Inflammatory or Locally Advanced Breast Cancer
This study is ongoing, but not recruiting participants.
Sponsor:
Southwest Oncology Group
Collaborator:
Information provided by (Responsible Party):
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT00856492
First received: March 4, 2009
Last updated: May 22, 2013
Last verified: May 2013
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Purpose
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them. Others interfere with the ability of tumor cells to grow and spread. Bevacizumab may also may stop the growth of tumor cells by blocking blood flow to the tumor. Giving these treatments before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known which treatment regimen is more effective in treating women with breast cancer.
PURPOSE: This randomized phase II trial is studying paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, cyclophosphamide, and pegfilgrastim to compare how well they work when given with or without bevacizumab in treating women with inflammatory or locally advanced breast cancer.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Cancer |
Biological: bevacizumab Biological: pegfilgrastim Drug: cyclophosphamide Drug: doxorubicin hydrochloride Drug: paclitaxel albumin-stabilized nanoparticle formulation |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Randomized Phase II Trial of Weekly Nanoparticle Albumin Bound Paclitaxel (Nab-Paclitaxel) (NSC-736631) With or Without Bevacizumab, Either Preceded by or Followed by Q 2 Week Doxorubicin (A)and Cyclophosphamide (C) Plus Pegfilgrastim (PEG-G) as Neoadjuvant Therapy For Inflammatory and Locally Advanced HER-2/NEU Negative Breast Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
Drug Information available for:
Cyclophosphamide
Doxorubicin
Doxorubicin hydrochloride
Paclitaxel
Pegfilgrastim
Bevacizumab
U.S. FDA Resources
Further study details as provided by Southwest Oncology Group:
Primary Outcome Measures:
- Pathological complete response rate [ Time Frame: pre-study pathology vs. post chemo surgery pathology ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Overall survival [ Time Frame: Disease assessed every 4 weeks while on treatment then every 6 months for one year then annually for four years from registration. ] [ Designated as safety issue: No ]
- Time to treatment failure [ Time Frame: Assessed every 4 weeks while on treatment. ] [ Designated as safety issue: No ]
- Disease-free survival [ Time Frame: Disease assessed every 4 weeks while on treatment then every 6 months for one year then annually for four years from registration or until recurrence ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 200 |
| Study Start Date: | April 2010 |
| Estimated Study Completion Date: | December 2016 |
| Estimated Primary Completion Date: | October 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Arm I
Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 and bevacizumab IV over 30- to 90-minutes on day 1 of weeks 1-12. Patients then receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 14, 16, 18, 20, 22, and 24.
|
Biological: bevacizumab
Given IV
Biological: pegfilgrastim
Given subcutaneously
Drug: cyclophosphamide
Given IV
Drug: doxorubicin hydrochloride
Given IV
Drug: paclitaxel albumin-stabilized nanoparticle formulation
Given IV
|
|
Active Comparator: Arm II
Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 1-12. Patients then receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 14, 16, 18, 20, 22, and 24.
|
Biological: pegfilgrastim
Given subcutaneously
Drug: cyclophosphamide
Given IV
Drug: doxorubicin hydrochloride
Given IV
Drug: paclitaxel albumin-stabilized nanoparticle formulation
Given IV
|
|
Active Comparator: Arm III
Patients receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 1, 3, 5, 7, 9, and 11. Patients then receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 14-25.
|
Biological: pegfilgrastim
Given subcutaneously
Drug: cyclophosphamide
Given IV
Drug: doxorubicin hydrochloride
Given IV
Drug: paclitaxel albumin-stabilized nanoparticle formulation
Given IV
|
Detailed Description:
OBJECTIVES:
- To compare the pathologic complete response rates in women with HER2/neu-negative inflammatory or locally advanced breast cancer treated with paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin hydrochloride, cyclophosphamide, and pegfilgrastim with vs without bevacizumab.
- To compare the overall survival of patients treated with these regimens.
- To assess whether there is a correlation between bevacizumab and stratification factors (type of disease and hormone receptor status).
- To compare the toxicities of these regimens.
- To explore the molecular biomarkers related to the biology and outcome of inflammatory breast cancer.
- To explore potential molecular biomarkers that predict response to therapy and drug sensitivity.
- To evaluate biomarkers with respect to the sequence of paclitaxel albumin-stabilized nanoparticle formulation and doxorubicin hydrochloride/cyclophosphamide/pegfilgrastim administration in patients not receiving bevacizumab.
- To explore residual cancer burden and correlate it with outcome.
- To evaluate the time to treatment failure prior to surgery.
- To evaluate disease-free survival from the time of surgery in patients undergoing definitive surgery.
OUTLINE: This is a multicenter study. Patients are stratified according to type of disease (inflammatory vs locally advanced breast cancer) and hormone receptor status (positive [estrogen receptor (ER)+ and/or progesterone receptor (PgR)+] vs negative [ER- and PgR-]). Patients are randomized to 1 of 3 treatment arms.
- Arm I: Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 and bevacizumab IV over 30- to 90-minutes on day 1 of weeks 1-12. Patients then receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 14, 16, 18, 20, 22, and 24.
- Arm II: Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 1-12. Patients then receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 14, 16, 18, 20, 22, and 24.
- Arm III: Patients receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 1, 3, 5, 7, 9, and 11. Patients then receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 14-25.
In all arms, patients with stable or responding disease undergo surgery 3-6 weeks after completion of chemotherapy. Patients may then undergo radiotherapy 5 days a week for 6 weeks.
Serum, whole blood, and tissue samples are collected periodically for biomarker analysis, circulating endothelial cell analysis, and pharmacogenomic studies, respectively.
After completion of study treatment, patients are followed every 6 months for 1 year and then annually for 4 years.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS:
Histologically or pathologically confirmed breast cancer meeting one of the following criteria:
- Locally advanced disease (stage IIIB disease, stage IIB/IIIA, or stage IIIC disease)
Inflammatory disease meeting the following two clinicopathologic criteria:
- Diffuse erythema AND edema (peau d'orange) of the breast involving the majority of the skin of the breast, i.e., more than 50%
- A biopsy demonstrating cancer either within the dermal lymphatics OR in the breast parenchyma itself
HER2/neu-negative tumor as demonstrated by 0 or 1+ (weak or no staining) by DAKO, IHC, or equivalent test OR no gene amplification by FISH*
- 2+ by DAKO or IHC allowed provided FISH* negative
- NOTE: *A negative FISH test ratio is < 1.8 or FISH HER2 gene copy < 4.0; if only a positive or negative result is available from the FISH test, a negative result is acceptable for study entry
- Hormone receptor status known
PATIENT CHARACTERISTICS:
- Menopausal status not specified
- Zubrod performance status 0-2
- Granulocyte count > 1,500/mm^3
- ANC ≥ 1,500/mm^3
- Platelet count > 100,000/mm^3
- Hemoglobin 9.0 g/dL
- Serum creatinine ≤ 1.5 times upper limit of normal (ULN)
- Bilirubin ≤ 1.5 mg/dL
- ALT and AST ≤ 3 times ULN
- Alkaline phosphatase ≤ 2.5 ULN (unless bone metastasis is present in the absence of liver metastasis)
- Urine protein:creatinine ratio ≤ 0.5 OR urine protein < 1,000 mg on 24-hour urine collection
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Able to take oral medications (e.g., no uncontrolled nausea, vomiting, or diarrhea, lack of physical integrity of the upper gastrointestinal tract, or malabsorption syndrome)
- QTc < 500 msec by EKG
- LVEF normal by MUGA or ECHO (for patients with hypertension or for patients > 60 years of age)
- NYHA class II cardiac function by baseline ECHO/MUGA (for patients who have received central thoracic radiotherapy that included the heart in the radiotherapy port, or for patients who have a history of class II heart failure but are asymptomatic on treatment are eligible)
No history of stroke (cerebrovascular accident), transient ischemic attack, or cardiac event within the past 12 months, including any of the following:
- Myocardial infarction (including severe/unstable angina)
- Coronary/peripheral artery bypass graft
- Symptomatic congestive heart failure
- Pulmonary embolism
- No poorly controlled hypertension, defined as recurrent or persistent (≥ 24 hours) elevated blood pressure (i.e., systolic blood pressure ≥ 140 mm Hg and/or diastolic blood pressure ≥ 90 mm Hg)
- No other malignancy within the past 5 years except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer
- Peripheral neuropathy < grade 2
PRIOR CONCURRENT THERAPY:
- No prior tyrosine kinase inhibitors
- More than 5 years since prior chemotherapy, radiotherapy, or biologic therapy (e.g., trastuzumab or bevacizumab) for invasive breast cancer
- At least 7 days since prior hormonal therapy
- At least 7 days since prior and no concurrent strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole) or grapefruit juice
- No concurrent CYP3A4 inducers (e.g., dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, St. John's wort)
- No other concurrent therapy for the treatment of breast cancer except for bisphosphonates
- No concurrent brachytherapy
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00856492
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Hide Study LocationsLocations
| United States, Alabama | |
| Providence Cancer Center at Providence Hospital | |
| Mobile, Alabama, United States, 36608 | |
| United States, Arkansas | |
| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | |
| Little Rock, Arkansas, United States, 72205 | |
| United States, California | |
| Alta Bates Summit Comprehensive Cancer Center | |
| Berkeley, California, United States, 94704 | |
| Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center | |
| Burbank, California, United States, 91505 | |
| Peninsula Medical Center | |
| Burlingame, California, United States, 94010 | |
| East Bay Radiation Oncology Center | |
| Castro Valley, California, United States, 94546 | |
| Valley Medical Oncology Consultants - Castro Valley | |
| Castro Valley, California, United States, 94546 | |
| Valley Medical Oncology | |
| Fremont, California, United States, 94538 | |
| Loma Linda University Cancer Institute at Loma Linda University Medical Center | |
| Loma Linda, California, United States, 92354 | |
| Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center | |
| Long Beach, California, United States, 90806 | |
| Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center | |
| Los Angeles, California, United States, 90048 | |
| USC/Norris Comprehensive Cancer Center and Hospital | |
| Los Angeles, California, United States, 90089-9181 | |
| Contra Costa Regional Medical Center | |
| Martinez, California, United States, 94553-3156 | |
| Tibotec Therapeutics - Division of Ortho Biotech Products, LP | |
| Marysville, California, United States, 95901 | |
| El Camino Hospital Cancer Center | |
| Mountain View, California, United States, 94040 | |
| Sutter Health - Western Division Cancer Research Group | |
| Novato, California, United States, 94945 | |
| Highland General Hospital | |
| Oakland, California, United States, 94602 | |
| Tom K Lee, Incorporated | |
| Oakland, California, United States, 94609 | |
| Bay Area Breast Surgeons, Incorporated | |
| Oakland, California, United States, 94609 | |
| Alta Bates Summit Medical Center - Summit Campus | |
| Oakland, California, United States, 94609 | |
| CCOP - Bay Area Tumor Institute | |
| Oakland, California, United States, 94609 | |
| Epic Care - Oakland | |
| Oakland, California, United States, 94612 | |
| Larry G Strieff MD Medical Corporation | |
| Oakland, California, United States, 94609 | |
| St. Joseph Hospital Regional Cancer Center - Orange | |
| Orange, California, United States, 92868 | |
| Desert Regional Medical Center Comprehensive Cancer Center | |
| Palm Springs, California, United States, 92262 | |
| Valley Medical Oncology Consultants - Pleasanton | |
| Pleasanton, California, United States, 94588 | |
| University of California Davis Cancer Center | |
| Sacramento, California, United States, 95817 | |
| California Pacific Medical Center - California Campus | |
| San Francisco, California, United States, 94118 | |
| Doctors Medical Center - San Pablo Campus | |
| San Pablo, California, United States, 94806 | |
| Sutter Pacific Medical Foundation | |
| Santa Rosa, California, United States, 95403 | |
| Tahoe Forest Cancer Center | |
| Truckee, California, United States, 96161 | |
| Sutter Solano Medical Center | |
| Vallejo, California, United States, 94589 | |
| United States, Colorado | |
| San Luis Valley Regional Medical Center | |
| Alamosa, Colorado, United States, 81101 | |
| University of Colorado Cancer Center at UC Health Sciences Center | |
| Aurora, Colorado, United States, 80045 | |
| Memorial Hospital Cancer Center - Colorado Springs | |
| Colorado Springs, Colorado, United States, 80909 | |
| Shaw Regional Cancer Center | |
| Edwards, Colorado, United States, 81632 | |
| Valley View Hospital Cancer Center | |
| Glenwood Springs, Colorado, United States, 81601 | |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | |
| Grand Junction, Colorado, United States, 81502 | |
| Montrose Memorial Hospital Cancer Center | |
| Montrose, Colorado, United States, 81401 | |
| United States, Connecticut | |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | |
| Hartford, Connecticut, United States, 06105 | |
| United States, Delaware | |
| Tunnell Cancer Center at Beebe Medical Center | |
| Lewes, Delaware, United States, 19958 | |
| CCOP - Christiana Care Health Services | |
| Newark, Delaware, United States, 19713 | |
| United States, Florida | |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | |
| Fort Lauderdale, Florida, United States, 33308 | |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | |
| Jupiter, Florida, United States, 33458 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| United States, Georgia | |
| Phoebe Cancer Center at Phoebe Putney Memorial Hospital | |
| Albany, Georgia, United States, 31701 | |
| Northeast Georgia Cancer Care, LLC - Medical Oncology | |
| Athens, Georgia, United States, 30607 | |
| CCOP - Atlanta Regional | |
| Atlanta, Georgia, United States, 30342 | |
| Saint Joseph's Hospital of Atlanta | |
| Atlanta, Georgia, United States, 30342-1701 | |
| Northside Hospital Cancer Center | |
| Atlanta, Georgia, United States, 30342-1611 | |
| Piedmont Hospital | |
| Atlanta, Georgia, United States, 30309 | |
| MBCCOP - Medical College of Georgia Cancer Center | |
| Augusta, Georgia, United States, 30912 | |
| WellStar Cobb Hospital | |
| Austell, Georgia, United States, 30106 | |
| John B. Amos Cancer Center | |
| Columbus, Georgia, United States, 31904 | |
| Charles B. Eberhart Cancer Center at DeKalb Medical Center | |
| Decatur, Georgia, United States, 30033 | |
| Piedmont Fayette Hospital | |
| Fayetteville, Georgia, United States, 30214 | |
| Northeast Georgia Medical Center | |
| Gainesville, Georgia, United States, 30501 | |
| Gwinnett Medical Center | |
| Lawrenceville, Georgia, United States, 30045 | |
| Kennestone Cancer Center at Wellstar Kennestone Hospital | |
| Marietta, Georgia, United States, 30060 | |
| Southern Regional Medical Center | |
| Riverdale, Georgia, United States, 30274-2600 | |
| Harbin Clinic Cancer Center - Medical Oncology | |
| Rome, Georgia, United States, 30165 | |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | |
| Savannah, Georgia, United States, 31405 | |
| United States, Hawaii | |
| Kapiolani Medical Center at Pali Momi | |
| Aiea, Hawaii, United States, 96701 | |
| OnCare Hawaii, Incorporated - Lusitana | |
| Honolulu, Hawaii, United States, 96813 | |
| Hawaii Medical Center - East | |
| Honolulu, Hawaii, United States, 96817 | |
| Kapiolani Medical Center for Women and Children | |
| Honolulu, Hawaii, United States, 96826 | |
| Queen's Cancer Institute at Queen's Medical Center | |
| Honolulu, Hawaii, United States, 96813 | |
| Cancer Research Center of Hawaii | |
| Honolulu, Hawaii, United States, 96813 | |
| Straub Clinic and Hospital, Incorporated | |
| Honolulu, Hawaii, United States, 96813 | |
| OnCare Hawaii, Incorporated - Kuakini | |
| Honolulu, Hawaii, United States, 96817 | |
| Castle Medical Center | |
| Kailua, Hawaii, United States, 96734 | |
| Kauai Medical Clinic | |
| Lihue, Hawaii, United States, 96766 | |
| Maui Memorial Medical Center | |
| Wailuku, Hawaii, United States, 96793 | |
| Pacific Cancer Institute - Maui | |
| Wailuku, Hawaii, United States, 96793 | |
| United States, Idaho | |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |
| Boise, Idaho, United States, 83706 | |
| St. Joseph Regional Medical Center | |
| Lewiston, Idaho, United States, 83501 | |
| United States, Illinois | |
| St. Joseph Medical Center | |
| Bloomington, Illinois, United States, 61701 | |
| Illinois CancerCare - Bloomington | |
| Bloomington%, Illinois, United States, 61701 | |
| Graham Hospital | |
| Canton, Illinois, United States, 61520 | |
| Illinois CancerCare - Canton | |
| Canton, Illinois, United States, 61520 | |
| Memorial Hospital | |
| Carthage, Illinois, United States, 62321 | |
| Illinois CancerCare - Carthage | |
| Carthage, Illinois, United States, 62321 | |
| Resurrection Medical Center | |
| Chicago, Illinois, United States, 60631 | |
| University of Chicago Cancer Research Center | |
| Chicago, Illinois, United States, 60637-1470 | |
| Decatur Memorial Hospital Cancer Care Institute | |
| Decatur, Illinois, United States, 62526 | |
| Illinois CancerCare - Eureka | |
| Eureka, Illinois, United States, 61530 | |
| Eureka Community Hospital | |
| Eureka, Illinois, United States, 61530 | |
| Illinois CancerCare - Galesburg | |
| Galesburg, Illinois, United States, 61401 | |
| Galesburg Clinic, PC | |
| Galesburg, Illinois, United States, 61401 | |
| Illinois CancerCare - Havana | |
| Havana, Illinois, United States, 62644 | |
| Mason District Hospital | |
| Havana, Illinois, United States, 62644 | |
| Illinois CancerCare - Kewanee Clinic | |
| Kewanee, Illinois, United States, 61443 | |
| McDonough District Hospital | |
| Macomb, Illinois, United States, 61455 | |
| Illinois CancerCare - Macomb | |
| Macomb, Illinois, United States, 61455 | |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |
| Maywood, Illinois, United States, 60153 | |
| Illinois CancerCare - Monmouth | |
| Monmouth, Illinois, United States, 61462 | |
| OSF Holy Family Medical Center | |
| Monmouth, Illinois, United States, 61462 | |
| BroMenn Regional Medical Center | |
| Normal, Illinois, United States, 61761 | |
| Community Cancer Center | |
| Normal, Illinois, United States, 61761 | |
| Illinois CancerCare - Community Cancer Center | |
| Normal, Illinois, United States, 61761 | |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | |
| Ottawa, Illinois, United States, 61350 | |
| Community Hospital of Ottawa | |
| Ottawa, Illinois, United States, 61350 | |
| Cancer Treatment Center at Pekin Hospital | |
| Pekin, Illinois, United States, 61554 | |
| Illinois CancerCare - Pekin | |
| Pekin, Illinois, United States, 61603 | |
| CCOP - Illinois Oncology Research Association | |
| Peoria, Illinois, United States, 61615 | |
| Methodist Medical Center of Illinois | |
| Peoria, Illinois, United States, 61636 | |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | |
| Peoria, Illinois, United States, 61615 | |
| OSF St. Francis Medical Center | |
| Peoria, Illinois, United States, 61637 | |
| Proctor Hospital | |
| Peoria, Illinois, United States, 61614 | |
| Illinois Valley Community Hospital | |
| Peru, Illinois, United States, 61354 | |
| Illinois CancerCare - Peru | |
| Peru, Illinois, United States, 61354 | |
| Illinois CancerCare - Princeton | |
| Princeton, Illinois, United States, 61356 | |
| Perry Memorial Hospital | |
| Princeton, Illinois, United States, 61356 | |
| Illinois CancerCare - Spring Valley | |
| Spring Valley, Illinois, United States, 61362 | |
| Regional Cancer Center at Memorial Medical Center | |
| Springfield, Illinois, United States, 62781-0001 | |
| United States, Indiana | |
| St. Francis Hospital and Health Centers - Beech Grove Campus | |
| Beech Grove, Indiana, United States, 46107 | |
| Fort Wayne Medical Oncology and Hematology | |
| Fort Wayne, Indiana, United States, 46845 | |
| Reid Hospital & Health Care Services | |
| Richmond, Indiana, United States, 47374 | |
| United States, Iowa | |
| McFarland Clinic, PC | |
| Ames, Iowa, United States, 50010 | |
| Mercy Medical Center - Sioux City | |
| Sioux City, Iowa, United States, 51102 | |
| Siouxland Hematology-Oncology Associates, LLP | |
| Sioux City, Iowa, United States, 51101 | |
| St. Luke's Regional Medical Center | |
| Sioux City, Iowa, United States, 51104 | |
| United States, Kansas | |
| Cancer Center of Kansas, PA - Chanute | |
| Chanute, Kansas, United States, 66720 | |
| Cancer Center of Kansas, PA - Dodge City | |
| Dodge City, Kansas, United States, 67801 | |
| Cancer Center of Kansas, PA - El Dorado | |
| El Dorado, Kansas, United States, 67042 | |
| Cancer Center of Kansas - Fort Scott | |
| Fort Scott, Kansas, United States, 66701 | |
| Cancer Center of Kansas-Independence | |
| Independence, Kansas, United States, 67301 | |
| Cancer Center of Kansas, PA - Kingman | |
| Kingman, Kansas, United States, 67068 | |
| Lawrence Memorial Hospital | |
| Lawrence, Kansas, United States, 66044 | |
| Cancer Center of Kansas, PA - Liberal | |
| Liberal, Kansas, United States, 67901 | |
| Cancer Center of Kansas, PA - McPherson | |
| McPherson, Kansas, United States, 67460 | |
| Cancer Center of Kansas, PA - Newton | |
| Newton, Kansas, United States, 67114 | |
| Saint Luke's Hospital - South | |
| Overland Park, Kansas, United States, 66213 | |
| Menorah Medical Center | |
| Overland Park, Kansas, United States, 66209 | |
| Cancer Center of Kansas, PA - Parsons | |
| Parsons, Kansas, United States, 67357 | |
| CCOP - Kansas City | |
| Prairie Village, Kansas, United States, 66208 | |
| Cancer Center of Kansas, PA - Pratt | |
| Pratt, Kansas, United States, 67124 | |
| Cancer Center of Kansas, PA - Salina | |
| Salina, Kansas, United States, 67401 | |
| Cancer Center of Kansas, PA - Wellington | |
| Wellington, Kansas, United States, 67152 | |
| Cancer Center of Kansas, PA - Wichita | |
| Wichita, Kansas, United States, 67214 | |
| CCOP - Wichita | |
| Wichita, Kansas, United States, 67214 | |
| Via Christi Cancer Center at Via Christi Regional Medical Center | |
| Wichita, Kansas, United States, 67214 | |
| Associates in Womens Health, PA - North Review | |
| Wichita, Kansas, United States, 67208 | |
| Cancer Center of Kansas, PA - Medical Arts Tower | |
| Wichita, Kansas, United States, 67208 | |
| Cancer Center of Kansas, PA - Winfield | |
| Winfield, Kansas, United States, 67156 | |
| United States, Louisiana | |
| Mary Bird Perkins Cancer Center - Baton Rouge | |
| Baton Rouge, Louisiana, United States, 70809 | |
| United States, Maryland | |
| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital | |
| Baltimore, Maryland, United States, 21215 | |
| Greater Baltimore Medical Center Cancer Center | |
| Baltimore, Maryland, United States, 21204 | |
| Union Hospital of Cecil County | |
| Elkton MD, Maryland, United States, 21921 | |
| Peninsula Regional Medical Center | |
| Salisbury, Maryland, United States, 21801 | |
| United States, Massachusetts | |
| Boston University Cancer Research Center | |
| Boston, Massachusetts, United States, 02118 | |
| United States, Michigan | |
| Hickman Cancer Center at Bixby Medical Center | |
| Adrian, Michigan, United States, 49221 | |
| Saint Joseph Mercy Cancer Center | |
| Ann Arbor, Michigan, United States, 48106-0995 | |
| CCOP - Michigan Cancer Research Consortium | |
| Ann Arbor, Michigan, United States, 48106 | |
| University of Michigan Comprehensive Cancer Center | |
| Ann Arbor, Michigan, United States, 48109-0942 | |
| Bay Regional Medical Center | |
| Bay City, Michigan, United States, 48708 | |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |
| Dearborn, Michigan, United States, 48123-2500 | |
| Josephine Ford Cancer Center at Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Barbara Ann Karmanos Cancer Institute | |
| Detroit, Michigan, United States, 48201-1379 | |
| Green Bay Oncology, Limited - Escanaba | |
| Escanaba, Michigan, United States, 49431 | |
| Genesys Hurley Cancer Institute | |
| Flint, Michigan, United States, 48503 | |
| McLaren Cancer Institute | |
| Flint, Michigan, United States, 48532 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| Singh and Arora Hematology Oncology, PC | |
| Flint, Michigan, United States, 48532 | |
| Genesys Regional Medical Center | |
| Grand Blanc, Michigan, United States, 48439 | |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | |
| Grosse Pointe Woods, Michigan, United States, 48236 | |
| Dickinson County Healthcare System | |
| Iron Mountain, Michigan, United States, 49801 | |
| Foote Memorial Hospital | |
| Jackson, Michigan, United States, 49201 | |
| Sparrow Regional Cancer Center | |
| Lansing, Michigan, United States, 48912-1811 | |
| Great Lakes Cancer Institute - Lapeer Campus | |
| Lapeer, Michigan, United States, 48446 | |
| St. Mary Mercy Hospital | |
| Livonia, Michigan, United States, 48154 | |
| MidMichigan Medical Center - Midland | |
| Midland, Michigan, United States, 48670 | |
| Mercy Memorial Hospital - Monroe | |
| Monroe, Michigan, United States, 48162 | |
| Clemens Regional Medical Center | |
| Mount Clemens, Michigan, United States, 48043 | |
| Northern Michigan Hospital | |
| Petoskey, Michigan, United States, 49770 | |
| St. Joseph Mercy Oakland | |
| Pontiac, Michigan, United States, 48341-2985 | |
| Mercy Regional Cancer Center at Mercy Hospital | |
| Port Huron, Michigan, United States, 48060 | |
| Seton Cancer Institute at Saint Mary's - Saginaw | |
| Saginaw, Michigan, United States, 48601 | |
| Providence Cancer Institute at Providence Hospital - Southfield Campus | |
| Southfield, Michigan, United States, 48075 | |
| St. John Macomb Hospital | |
| Warren, Michigan, United States, 48093 | |
| United States, Minnesota | |
| Fairview Ridges Hospital | |
| Burnsville, Minnesota, United States, 55337 | |
| Mercy and Unity Cancer Center at Mercy Hospital | |
| Coon Rapids, Minnesota, United States, 55433 | |
| Fairview Southdale Hospital | |
| Edina, Minnesota, United States, 55435 | |
| Mercy and Unity Cancer Center at Unity Hospital | |
| Fridley, Minnesota, United States, 55432 | |
| Hutchinson Area Health Care | |
| Hutchinson, Minnesota, United States, 55350 | |
| HealthEast Cancer Care at St. John's Hospital | |
| Maplewood, Minnesota, United States, 55109 | |
| Minnesota Oncology - Maplewood | |
| Maplewood, Minnesota, United States, 55109 | |
| Hennepin County Medical Center - Minneapolis | |
| Minneapolis, Minnesota, United States, 55415 | |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |
| Minneapolis, Minnesota, United States, 55407 | |
| New Ulm Medical Center | |
| New Ulm, Minnesota, United States, 56073 | |
| Humphrey Cancer Center at North Memorial Outpatient Center | |
| Robbinsdale, Minnesota, United States, 55422-2900 | |
| CCOP - Metro-Minnesota | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| Park Nicollet Cancer Center | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United Hospital | |
| Saint Paul, Minnesota, United States, 55102 | |
| St. Francis Cancer Center at St. Francis Medical Center | |
| Shakopee, Minnesota, United States, 55379 | |
| Regions Hospital Cancer Care Center | |
| St. Paul, Minnesota, United States, 55101 | |
| Lakeview Hospital | |
| Stillwater, Minnesota, United States, 55082 | |
| Ridgeview Medical Center | |
| Waconia, Minnesota, United States, 55387 | |
| Willmar Cancer Center at Rice Memorial Hospital | |
| Willmar, Minnesota, United States, 56201 | |
| Minnesota Oncology - Woodbury | |
| Woodbury, Minnesota, United States, 55125 | |
| United States, Mississippi | |
| University of Mississippi Cancer Clinic | |
| Jackson, Mississippi, United States, 39216 | |
| Regional Cancer Center at Singing River Hospital | |
| Pascagoula, Mississippi, United States, 39581 | |
| United States, Missouri | |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | |
| Columbia, Missouri, United States, 65203 | |
| St. John's Regional Medical Center | |
| Joplin, Missouri, United States, 64804 | |
| Heartland Hematology Oncology Associates, Incorporated | |
| Kansas City, Missouri, United States, 64118 | |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | |
| Kansas City, Missouri, United States, 64111 | |
| Research Medical Center | |
| Kansas City, Missouri, United States, 64132 | |
| North Kansas City Hospital | |
| Kansas City, Missouri, United States, 64116 | |
| Saint Luke's East - Lee's Summit | |
| Lee's Summit, Missouri, United States, 64086 | |
| Parvin Radiation Oncology | |
| Liberty, Missouri, United States, 64068 | |
| Phelps County Regional Medical Center | |
| Rolla, Missouri, United States, 65401 | |
| Saint Joseph Oncology, Incorporated | |
| Saint Joseph, Missouri, United States, 64507 | |
| Heartland Regional Medical Center | |
| Saint Joseph, Missouri, United States, 64506 | |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |
| Saint Louis, Missouri, United States, 63110 | |
| Hulston Cancer Center at Cox Medical Center South | |
| Springfield, Missouri, United States, 65807 | |
| St. John's Regional Health Center | |
| Springfield, Missouri, United States, 65804 | |
| CCOP - Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65802 | |
| United States, Montana | |
| Billings Clinic - Downtown | |
| Billings, Montana, United States, 59107-7000 | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| St. Vincent Healthcare Cancer Care Services | |
| Billings, Montana, United States, 59101 | |
| Hematology-Oncology Centers of the Northern Rockies - Billings | |
| Billings, Montana, United States, 59102 | |
| Bozeman Deaconess Cancer Center | |
| Bozeman, Montana, United States, 59715 | |
| St. James Healthcare Cancer Care | |
| Butte, Montana, United States, 59701 | |
| Big Sky Oncology | |
| Great Falls, Montana, United States, 59405-5309 | |
| Great Falls Clinic - Main Facility | |
| Great Falls, Montana, United States, 59405 | |
| Sletten Cancer Institute at Benefis Healthcare | |
| Great Falls, Montana, United States, 59405 | |
| St. Peter's Hospital | |
| Helena, Montana, United States, 59601 | |
| Glacier Oncology, PLLC | |
| Kalispell, Montana, United States, 59901 | |
| Kalispell Regional Medical Center | |
| Kalispell, Montana, United States, 59901 | |
| Kalispell Medical Oncology at KRMC | |
| Kalispell, Montana, United States, 59901 | |
| Montana Cancer Specialists at Montana Cancer Center | |
| Missoula, Montana, United States, 59807-7877 | |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | |
| Missoula, Montana, United States, 59807 | |
| United States, New Jersey | |
| Hunterdon Regional Cancer Center at Hunterdon Medical Center | |
| Flemington, New Jersey, United States, 08822 | |
| Cancer Institute of New Jersey at Cooper - Voorhees | |
| Voorhees, New Jersey, United States, 08043 | |
| United States, New Mexico | |
| Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital | |
| Albuquerque, New Mexico, United States, 87110 | |
| University of New Mexico Cancer Center | |
| Albuquerque, New Mexico, United States, 87131-5636 | |
| University of New Mexico Cancer Center - South | |
| Las Cruces, New Mexico, United States, 88011 | |
| United States, New York | |
| Charles R. Wood Cancer Center at Glens Falls Hospital | |
| Glens Falls, New York, United States, 12801 | |
| Nalitt Cancer Institute at Staten Island University Hospital | |
| Staten Island, New York, United States, 10305 | |
| United States, North Carolina | |
| Wayne Memorial Hospital, Incorporated | |
| Goldsboro, North Carolina, United States, 27534 | |
| Kinston Medical Specialists | |
| Kinston, North Carolina, United States, 28501 | |
| Rutherford Hospital | |
| Rutherfordton, North Carolina, United States, 28139 | |
| Iredell Memorial Hospital | |
| Statesville, North Carolina, United States, 28677 | |
| United States, Ohio | |
| Summa Center for Cancer Care at Akron City Hospital | |
| Akron, Ohio, United States, 44309-2090 | |
| Barberton Citizens Hospital | |
| Barberton, Ohio, United States, 44203 | |
| Cleveland Clinic Beachwood Family Health and Surgery Center | |
| Beachwood, Ohio, United States, 44122 | |
| Adena Regional Medical Center | |
| Chillicothe, Ohio, United States, 45601 | |
| Cleveland Clinic Taussig Cancer Center | |
| Cleveland, Ohio, United States, 44195 | |
| Cleveland Clinic Cancer Center at Fairview Hospital | |
| Cleveland, Ohio, United States, 44111 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43215 | |
| Mount Carmel Health - West Hospital | |
| Columbus, Ohio, United States, 43222 | |
| Grant Medical Center Cancer Care | |
| Columbus, Ohio, United States, 43215 | |
| Riverside Methodist Hospital Cancer Care | |
| Columbus, Ohio, United States, 43214-3998 | |
| Doctors Hospital at Ohio Health | |
| Columbus, Ohio, United States, 43228 | |
| Grandview Hospital | |
| Dayton, Ohio, United States, 45405 | |
| CCOP - Dayton | |
| Dayton, Ohio, United States, 45420 | |
| David L. Rike Cancer Center at Miami Valley Hospital | |
| Dayton, Ohio, United States, 45409 | |
| Good Samaritan Hospital | |
| Dayton, Ohio, United States, 45406 | |
| Samaritan North Cancer Care Center | |
| Dayton, Ohio, United States, 45415 | |
| Grady Memorial Hospital | |
| Delaware, Ohio, United States, 43015 | |
| Community Cancer Center | |
| Elyria, Ohio, United States, 44035 | |
| Hematology Oncology Center | |
| Elyria, Ohio, United States, 44035 | |
| Blanchard Valley Medical Associates | |
| Findlay, Ohio, United States, 45840 | |
| Middletown Regional Hospital | |
| Franklin, Ohio, United States, 45005-1066 | |
| Wayne Hospital | |
| Greenville, Ohio, United States, 45331 | |
| Cleveland Clinic Cancer Center | |
| Independence, Ohio, United States, 44131 | |
| Charles F. Kettering Memorial Hospital | |
| Kettering, Ohio, United States, 45429 | |
| Fairfield Medical Center | |
| Lancaster, Ohio, United States, 43130 | |
| Lima Memorial Hospital | |
| Lima, Ohio, United States, 45804 | |
| Strecker Cancer Center at Marietta Memorial Hospital | |
| Marietta, Ohio, United States, 45750 | |
| Northwest Ohio Oncology Center | |
| Maumee, Ohio, United States, 43537-1839 | |
| Hillcrest Cancer Center at Hillcrest Hospital | |
| Mayfield Heights, Ohio, United States, 44124 | |
| Knox Community Hospital | |
| Mount Vernon, Ohio, United States, 43050 | |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | |
| Newark, Ohio, United States, 43055 | |
| St. Charles Mercy Hospital | |
| Oregon, Ohio, United States, 43616 | |
| Parma Community General Hospital | |
| Parma, Ohio, United States, 44129 | |
| Southern Ohio Medical Center Cancer Center | |
| Portsmouth, Ohio, United States, 45662 | |
| North Coast Cancer Care, Incorporated | |
| Sandusky, Ohio, United States, 44870 | |
| Community Hospital of Springfield and Clark County | |
| Springfield, Ohio, United States, 45505 | |
| Cleveland Clinic Foundation - Strongsville | |
| Strongsville, Ohio, United States, 44136 | |
| Flower Hospital Cancer Center | |
| Sylvania, Ohio, United States, 43560 | |
| Mercy Hospital of Tiffin | |
| Tiffin, Ohio, United States, 44883 | |
| St. Vincent Mercy Medical Center | |
| Toledo, Ohio, United States, 43608 | |
| Toledo Hospital | |
| Toledo, Ohio, United States, 43606 | |
| Toledo Clinic, Incorporated - Main Clinic | |
| Toledo, Ohio, United States, 43623 | |
| St. Anne Mercy Hospital | |
| Toledo, Ohio, United States, 43623 | |
| Medical University of Ohio Cancer Center | |
| Toledo, Ohio, United States, 43614 | |
| CCOP - Toledo Community Hospital | |
| Toledo, Ohio, United States, 43617 | |
| UVMC Cancer Care Center at Upper Valley Medical Center | |
| Troy, Ohio, United States, 45373-1300 | |
| Fulton County Health Center | |
| Wauseon, Ohio, United States, 43567 | |
| Mount Carmel St. Ann's Cancer Center | |
| Westerville, Ohio, United States, 43081 | |
| Cleveland Clinic - Wooster | |
| Wooster, Ohio, United States, 44691 | |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |
| Xenia, Ohio, United States, 45385 | |
| Genesis - Good Samaritan Hospital | |
| Zanesville, Ohio, United States, 43701 | |
| United States, Oregon | |
| Legacy Mount Hood Medical Center | |
| Gresham, Oregon, United States, 97030 | |
| Legacy Emanuel Hospital and Health Center and Children's Hospital | |
| Portland, Oregon, United States, 97227 | |
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | |
| Portland, Oregon, United States, 97210 | |
| Legacy Meridian Park Hospital | |
| Tualatin, Oregon, United States, 97062 | |
| United States, Pennsylvania | |
| Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | |
| Hershey, Pennsylvania, United States, 17033-0850 | |
| Lewistown Hospital | |
| Lewistown, Pennsylvania, United States, 17044 | |
| Pottstown Memorial Regional Cancer Center | |
| Pottstown, Pennsylvania, United States, 19464 | |
| Mount Nittany Medical Center | |
| State College, Pennsylvania, United States, 16803 | |
| United States, South Carolina | |
| AnMed Cancer Center | |
| Anderson, South Carolina, United States, 29621 | |
| McLeod Regional Medical Center | |
| Florence, South Carolina, United States, 29501 | |
| Bon Secours St. Francis Health System | |
| Greenville, South Carolina, United States, 29601 | |
| CCOP - Upstate Carolina | |
| Spartanburg, South Carolina, United States, 29303 | |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | |
| Spartanburg, South Carolina, United States, 29303 | |
| United States, South Dakota | |
| Rapid City Regional Hospital | |
| Rapid City, South Dakota, United States, 57701 | |
| United States, Tennessee | |
| Erlanger Cancer Center at Erlanger Hospital - Baroness | |
| Chattanooga, Tennessee, United States, 37403 | |
| Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | |
| Kingsport, Tennessee, United States, 37662 | |
| United States, Texas | |
| Doctor's Hospital of Laredo | |
| Laredo, Texas, United States, 78045 | |
| CCOP - Scott and White Hospital | |
| Temple, Texas, United States, 76508 | |
| United States, Utah | |
| American Fork Hospital | |
| American Fork, Utah, United States, 84003 | |
| Sandra L. Maxwell Cancer Center | |
| Cedar City, Utah, United States, 84720 | |
| Logan Regional Hospital | |
| Logan, Utah, United States, 84321 | |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | |
| Murray, Utah, United States, 84157 | |
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | |
| Ogden, Utah, United States, 84403 | |
| Utah Valley Regional Medical Center - Provo | |
| Provo, Utah, United States, 84604 | |
| Dixie Regional Medical Center - East Campus | |
| Saint George, Utah, United States, 84770 | |
| Utah Cancer Specialists at UCS Cancer Center | |
| Salt Lake City, Utah, United States, 84106 | |
| LDS Hospital | |
| Salt Lake City, Utah, United States, 84143 | |
| United States, Virginia | |
| Fredericksburg Oncology, Incorporated | |
| Fredericksburg, Virginia, United States, 22401 | |
| Southwest Virginia Regional Cancer Center at Wellmonth Health | |
| Norton, Virginia, United States, 24273 | |
| United States, Washington | |
| Island Hospital Cancer Care Center at Island Hospital | |
| Anacortes, Washington, United States, 98221 | |
| Overlake Cancer Center at Overlake Hospital Medical Center | |
| Bellevue, Washington, United States, 98004 | |
| St. Joseph Cancer Center | |
| Bellingham, Washington, United States, 98225 | |
| Olympic Hematology and Oncology | |
| Bremerton, Washington, United States, 98310 | |
| Highline Medical Center Cancer Center | |
| Burien, Washington, United States, 98166 | |
| Providence Centralia Hospital | |
| Centralia, Washington, United States, 98531-9027 | |
| Providence Regional Cancer Partnership | |
| Everett, Washington, United States, 98201 | |
| St. Francis Hospital | |
| Federal Way, Washington, United States, 98003 | |
| Swedish Medical Center - Issaquah Campus | |
| Issaquah, Washington, United States, 98029 | |
| Columbia Basin Hematology | |
| Kennewick, Washington, United States, 99336 | |
| Skagit Valley Hospital Cancer Care Center | |
| Mount Vernon, Washington, United States, 98274 | |
| Providence St. Peter Hospital Regional Cancer Center | |
| Olympia, Washington, United States, 98506-5166 | |
| Harrison Poulsbo Hematology and Onocology | |
| Poulsbo, Washington, United States, 98370 | |
| Good Samaritan Cancer Center | |
| Puyallup, Washington, United States, 98372 | |
| Group Health Central Hospital | |
| Seattle, Washington, United States, 98112 | |
| Harborview Medical Center | |
| Seattle, Washington, United States, 98104 | |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | |
| Seattle, Washington, United States, 98122-4307 | |
| University Cancer Center at University of Washington Medical Center | |
| Seattle, Washington, United States, 98195 | |
| Polyclinic First Hill | |
| Seattle, Washington, United States, 98122 | |
| Fred Hutchinson Cancer Research Center | |
| Seattle, Washington, United States, 98109 | |
| North Puget Oncology at United General Hospital | |
| Sedro-Woolley, Washington, United States, 98284 | |
| Providence Cancer Center at Sacred Heart Medical Center | |
| Spokane, Washington, United States, 99204 | |
| Cancer Care Northwest - Spokane South | |
| Spokane, Washington, United States, 99202 | |
| Evergreen Hematology and Oncology, PS | |
| Spokane, Washington, United States, 99218 | |
| CCOP - Northwest | |
| Tacoma, Washington, United States, 98405 | |
| Franciscan Cancer Center at St. Joseph Medical Center | |
| Tacoma, Washington, United States, 98405-3004 | |
| MultiCare Regional Cancer Center at Tacoma General Hospital | |
| Tacoma, Washington, United States, 98405 | |
| St. Clare Hospital | |
| Tacoma, Washington, United States, 98499 | |
| Allenmore Hospital | |
| Tacoma, Washington, United States, 98405 | |
| Legacy Salmon Creek Medical Center | |
| Vancouver, Washington, United States, 98686 | |
| Wenatchee Valley Medical Center | |
| Wenatchee, Washington, United States, 98801-2028 | |
| United States, Wisconsin | |
| St. Mary's Hospital Medical Center - Green Bay | |
| Green Bay, Wisconsin, United States, 54303 | |
| St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54307-3508 | |
| Green Bay Oncology, Limited at St. Mary's Hospital | |
| Green Bay, Wisconsin, United States, 54303 | |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54301-3526 | |
| Gundersen Lutheran Center for Cancer and Blood | |
| La Crosse, Wisconsin, United States, 54601 | |
| Holy Family Memorial Medical Center Cancer Care Center | |
| Manitowoc, Wisconsin, United States, 54221-1450 | |
| Bay Area Cancer Care Center at Bay Area Medical Center | |
| Marinette, Wisconsin, United States, 54143 | |
| Green Bay Oncology, Limited - Oconto Falls | |
| Oconto Falls, Wisconsin, United States, 54154 | |
| St. Nicholas Hospital | |
| Sheboygan, Wisconsin, United States, 53081 | |
| Green Bay Oncology, Limited - Sturgeon Bay | |
| Sturgeon Bay, Wisconsin, United States, 54235 | |
| United States, Wyoming | |
| Rocky Mountain Oncology | |
| Casper, Wyoming, United States, 82609 | |
| Puerto Rico | |
| San Juan City Hospital | |
| San Juan, Puerto Rico, 00936 | |
Sponsors and Collaborators
Southwest Oncology Group
Investigators
| Principal Investigator: | Zeina Nahleh, MD | Barbara Ann Karmanos Cancer Institute |
More Information
Additional Information:
No publications provided
| Responsible Party: | Southwest Oncology Group |
| ClinicalTrials.gov Identifier: | NCT00856492 History of Changes |
| Other Study ID Numbers: | CDR0000636131, S0800, U10CA032102 |
| Study First Received: | March 4, 2009 |
| Last Updated: | May 22, 2013 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by Southwest Oncology Group:
|
inflammatory breast cancer stage II breast cancer stage IIIA breast cancer stage IIIB breast cancer HER2-negative breast cancer |
estrogen receptor-negative breast cancer estrogen receptor-positive breast cancer progesterone receptor-negative breast cancer progesterone receptor-positive breast cancer stage IIIC breast cancer |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Cyclophosphamide Bevacizumab Doxorubicin Paclitaxel Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Pharmacologic Actions Antirheumatic Agents Therapeutic Uses |
Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Myeloablative Agonists Antibiotics, Antineoplastic Tubulin Modulators Antimitotic Agents Mitosis Modulators Antineoplastic Agents, Phytogenic Angiogenesis Inhibitors Angiogenesis Modulating Agents Growth Substances Growth Inhibitors |
ClinicalTrials.gov processed this record on June 18, 2013