Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Evaluation of Pharmacogenetic Factors Contributing to Dose Requirement of Fentanyl for Postoperative Pain Control: Genetic Polymorphisms of OPRM1, ABCB1, CYP3A4 and CYP3A5|
- Postoperative Cumulative Fentanyl Consumption [ Time Frame: 24 hr after surgery ] [ Designated as safety issue: No ]
- Postoperative Cumulative Fentanyl Consumption [ Time Frame: 48hr after surgery ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||September 2008|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.
|Korea, Republic of|
|Inje University Sanggye Paik Hospital|
|Seoul, Korea, Republic of, 139-707|
|Principal Investigator:||Kye-Min Kim, MD. PhD.||Department of Anesthesia, Inje University Sanggye Paik Hospital|