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The Genetics of Diabetes in Southern California Chinese Americans

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2011 by University of California, Irvine.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Doris Duke Charitable Foundation
Information provided by:
University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00824395
First received: January 15, 2009
Last updated: February 2, 2011
Last verified: February 2011
History of Changes
  Purpose

The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.


Condition
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of California, Irvine:

Biospecimen Retention:   Samples With DNA

whole blood and serum


Estimated Enrollment: 500
Study Start Date: January 2006
Estimated Study Completion Date: November 2010
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Individuals with diabetes
2
Individuals without diabetes

Detailed Description:

Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.

  Eligibility

Ages Eligible for Study:   40 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.

Criteria

Inclusion Criteria:

  • Chinese or Taiwanese ancestry
  • Resident of Southern California
  • Age between 40 and 65
  • Both people with and without diabetes are welcome to enroll.

Exclusion Criteria:

  • Younger than 40 years or older than 65 years
  • Ancestry is not Chinese or Taiwanese
  • Not a resident of Southern California
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00824395

Contacts
Contact: Julia Platt, MS 949-824-9232 jplatt@uci.edu
Contact: Shiqin Xu, PhD 949-892-7645 shiqinx@uci.edu

Locations
United States, California
UC Irvine General Clinical Research Center Recruiting
Irvine, California, United States, 92697
Contact: Julia Platt, MS     949-824-9232     jplatt@uci.edu    
Sponsors and Collaborators
University of California, Irvine
Doris Duke Charitable Foundation
Investigators
Principal Investigator: Douglas C Wallace, PhD UC Irvine Center for Mitochondrial Medicine
  More Information

No publications provided

Responsible Party: Douglas C. Wallace, Ph.D / Principal Investigator, UC Irvine Center for Mitochondrial Medicine and Genetics
ClinicalTrials.gov Identifier: NCT00824395     History of Changes
Other Study ID Numbers: 2005-4675
Study First Received: January 15, 2009
Last Updated: February 2, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Irvine:
diabetes
type 1
type 2
metabolic syndrome
mitochondria

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Metabolic Syndrome X
Glucose Metabolism Disorders
Metabolic Diseases
 Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases
Insulin Resistance
Hyperinsulinism

ClinicalTrials.gov processed this record on June 18, 2013