Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage III or Stage IV Breast Cancer

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00601900
First received: January 18, 2008
Last updated: July 23, 2014
Last verified: July 2014
  Purpose

This randomized phase III trial is studying giving tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in treating women with stage III or stage IV breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate* or letrozole may fight breast cancer by blocking the use of estrogen by the tumor cells. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether giving hormone therapy is more effective with or without bevacizumab in treating advanced breast cancer.


Condition Intervention Phase
Recurrent Breast Cancer
Stage IIIB Breast Cancer
Stage IV Breast Cancer
Drug: tamoxifen citrate
Drug: letrozole
Biological: bevacizumab
Other: laboratory biomarker analysis
Other: questionnaire administration
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Endocrine Therapy With or Without Anti-VEGF Therapy: A Randomized, Phase III Trial of Endocrine Therapy Alone or Endocrine Therapy Plus Bevacizumab (NSC 704865) for Women With Hormone Receptor-Positive Advanced Breast Cancer

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Progression-free survival [ Time Frame: From randomization until disease progression or death, assessed up to 5 years ] [ Designated as safety issue: No ]
  • Adverse events rate, especially for stroke, proteinuria, thrombosis, and hypertension in patients treated with tamoxifen citrate (As of 5/15/2011, patients only receive letrozole) [ Time Frame: Within 30 days of the last dose of investigational agent ] [ Designated as safety issue: Yes ]
    Graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Interpreted using P-values from the chi-square test (with one-sided alpha of 0.05).

  • Occurrence of grade 3, 4, or 5 toxicity [ Time Frame: Assessed up to 5 years ] [ Designated as safety issue: Yes ]
    Graded using the NCI CTCAE version 4.0.


Secondary Outcome Measures:
  • Objective tumor response as defined by RECIST criteria for patients with measurable disease [ Time Frame: Assessed up to 5 years ] [ Designated as safety issue: No ]
  • Probability of being progression-free [ Time Frame: At 6 months ] [ Designated as safety issue: No ]
    Difference in proportions tested using the chi-square test.

  • Probability of being progression-free [ Time Frame: At 12 months ] [ Designated as safety issue: No ]
    Difference in proportions tested using the chi-square test.

  • Site of progression [ Time Frame: Assessed up to 5 years ] [ Designated as safety issue: No ]
  • Treatment related toxicity [ Time Frame: Assessed up to 5 years ] [ Designated as safety issue: Yes ]
    Graded using the NCI CTCAE version 4.0. Tabulated by type, grade, and arm.

  • Time-to-treatment failure [ Time Frame: From randomization until first disease progression, early termination of protocol therapy due to toxicity or withdrawn consent, or beginning non-protocol therapy, whichever occurs first, assessed up to 5 years ] [ Designated as safety issue: No ]
    Defined by RECIST criteria.

  • Duration of tumor response [ Time Frame: From the time measurement criteria are met for CR/PR (whichever is first recorded) until the first date that recurrent or progressive disease is objectively documented, assessed up to 5 years ] [ Designated as safety issue: No ]
    Defined by RECIST criteria.

  • Overall survival (OS) [ Time Frame: Assessed up to 5 years ] [ Designated as safety issue: No ]
    Compared with a Kaplan-Meier analysis. 90% confidence interval will be calculated.

  • Probability of surviving until 36 months [ Time Frame: At 36 months ] [ Designated as safety issue: No ]

Other Outcome Measures:
  • PFS predicted by CTCs and CECs measured at baseline [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    Descriptive statistics and proportional hazards regression modeling will be examined. A variety of functional forms, including untransformed values, logarithms, and cut points will be used, as will regression trees and loess plots within test/validation samples to explore cutpoints.

  • Longitudinal aspect of CTC and CEC levels [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    A multivariate proportional hazards model that relates various functional forms of CTC and CEC levels to the hazard of progression. The mixed linear model will be used to test for arm differences in changes in CTCs and CECs across time.

  • Correlation of PIK3CA with CECs [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with dichotomous markers will be assessed with contingency tables and the chi-square test. A variety of functional forms will be considered through the use of cutpoints, loess plots and restricted cubic splines.

  • Correlation of PIK3CA with CTCs [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with dichotomous markers will be assessed with contingency tables and the chi-square test. A variety of functional forms will be considered through the use of cutpoints, loess plots and restricted cubic splines.

  • Correlation of PIK3CA with VEGF [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with continuous markers such as VEGF will be assessed by using the logistic regression model to examine the functional form of the association. A variety of functional forms will be examined through the use of cutpoints, loess plots and restricted cubic splines.

  • Correlation of PIK3CA with CD31 [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with continuous markers will be assessed by using the logistic regression model to examine the functional form of the association. A variety of functional forms will be examined through the use of cutpoints, loess plots and restricted cubic splines.

  • Correlation of PIK3CA with AR [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with continuous markers will be assessed by using the logistic regression model to examine the functional form of the association. A variety of functional forms will be examined through the use of cutpoints, loess plots and restricted cubic splines.

  • Correlation of PIK3CA with Luminal subtype [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    The association of PIK3CA with continuous markers will be assessed by using the logistic regression model to examine the functional form of the association. A variety of functional forms will be examined through the use of cutpoints, loess plots and restricted cubic splines.

  • Improvement in PFS due to bevacizumab depends on the VEGF gene [ Time Frame: Assessed up to 3 years ] [ Designated as safety issue: No ]
    This will be investigated in the framework of a two-way multiplicative log-linear Cox model with factors drug (P=control or B=bevacizumab) and VEGF gene (1=CT/TT or 2=CC).

  • Identify SNPs associated with PFS [ Time Frame: Assessed up to 3 years ] [ Designated as safety issue: No ]
    Logistic regression models and conditional inference trees (or more generally conditional random forests) will be used to construct multi-variable models based on the SNPs identified as interesting. This model also allows for inclusion of other potentially relevant clinical demographic variables.

  • Association between each CNV marker and the clinical adverse event (AE) endpoint [ Time Frame: Assessed up to 3 years ] [ Designated as safety issue: No ]
    This will be assessed using the Wilcoxon two-sample test. Regression methods, as in the case of the SNP markers, will be employed to construct multivariable models based on the CVN markers.

  • Associations between the occurrence of grade 3, 4, or 5 toxicity and clinical factors [ Time Frame: Baseline to 3 years ] [ Designated as safety issue: No ]
    To account for multiple comparisons in the primary objective, a Bonferroni correction will be applied to a two-sided Type I error of 0.05. For the continuous factors (Medical Outcome Study [MOS] Physical Functioning, Karnofsky Performance Status Rated Healthcare Professional, Timed "Up and Go", Older American Resources and Services [OARS] Physical Health Section), logistic regression will be used to determine the odds ratio of toxicity.


Enrollment: 394
Study Start Date: May 2008
Study Completion Date: June 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (endocrine therapy with monoclonal antibody)
Patients receive endocrine therapy* (tamoxifen citrate* or letrozole) PO QD on days 1-21 and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: tamoxifen citrate
Given PO
Other Names:
  • Nolvadex
  • TAM
  • tamoxifen
  • TMX
Drug: letrozole
Given PO
Other Names:
  • CGS 20267
  • Femara
  • LTZ
Biological: bevacizumab
Given IV
Other Names:
  • anti-VEGF humanized monoclonal antibody
  • anti-VEGF monoclonal antibody
  • Avastin
  • rhuMAb VEGF
Other: laboratory biomarker analysis
Correlative studies
Other: questionnaire administration
Ancillary studies
Active Comparator: Arm II (endocrine therapy)
Patients receive endocrine therapy* (tamoxifen citrate* or letrozole) PO QD on days 1-21. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: tamoxifen citrate
Given PO
Other Names:
  • Nolvadex
  • TAM
  • tamoxifen
  • TMX
Drug: letrozole
Given PO
Other Names:
  • CGS 20267
  • Femara
  • LTZ
Other: laboratory biomarker analysis
Correlative studies
Other: questionnaire administration
Ancillary studies

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologic confirmation of invasive cancer of the female breast in either the primary or metastatic setting

    • Stage IV disease or stage IIIB disease (using American Joint Committee on Cancer [AJCC] criteria, 6th edition) not amenable to local therapy
  • Patients may not have a "currently active" second malignancy other than non-melanoma skin cancers; patients are not considered to have a "currently active" malignancy if they have completed therapy and are considered by their physician to be at less than 30% risk of relapse
  • Tumors (from either primary or metastatic sites) must express estrogen receptor (ER) and/or progesterone receptor (PgR) in >= 1% of cells will be considered positive
  • Postmenopausal women are eligible for this trial; before study registration, menopausal status must be defined according to the criteria below:

    • Age >= 55 years and one year or more of amenorrhea
    • Age < 55 years and one year or more of amenorrhea, with an estradiol assay < 20 pg/ml
    • For women age < 55 with prior hysterectomy but intact ovaries, with an estradiol assay < 20 pg/ml
    • Surgical menopause with bilateral oophorectomy (at least 28 days must elapse from surgery to time of study registration)
    • Ovarian suppression on a luteinizing hormone-releasing hormone (LH-RH) agonist
  • Premenopausal women who do not meet the postmenopausal criteria above are also eligible, but are required to undergo ovarian suppression; this can be initiated any time prior to or on day 1 of protocol therapy, regardless of chosen endocrine therapy, and will continue for the duration of protocol therapy
  • Must have measurable or nonmeasurable disease by RECIST criteria, with radiologic scans

    • Measurable disease: lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as >= 2.0 cm with conventional techniques or as >= 1.0 cm with spiral computed tomography (CT) scan
    • Nonmeasurable disease: all other lesions, including small lesions (longest diameter < 2.0 cm with conventional techniques or < 1.0 cm with spiral CT scan) and truly nonmeasurable lesions, including any of the following:

      • Bone lesions
      • Leptomeningeal disease
      • Ascites
      • Pleural/pericardial effusion
      • Inflammatory breast disease
      • Abdominal masses that are not confirmed and followed by imaging techniques
      • Cystic lesions
  • Prior endocrine therapy is not required

    • Prior endocrine therapy in the metastatic setting is not permitted (unless tamoxifen or an aromatase inhibitor was initiated within 4 weeks prior to registration to facilitate enrollment of patients who recently started first-line endocrine therapy for metastatic breast cancer); if prior letrozole therapy was initiated within the past 4 weeks, the patients should remain on letrozole as the study therapy; patients who began therapy with tamoxifen, anastrozole or exemestane must switch to letrozole to be eligible to participate in this study
    • Prior endocrine therapy in the adjuvant setting is permitted; there is no time restriction for how long the patient must be on the adjuvant endocrine therapy, nor is there a time restriction for how long the patient needs to be off prior adjuvant endocrine therapy before beginning protocol therapy on 40503
    • Prior treatment with ovarian suppression is allowed in either the adjuvant or metastatic setting; if medical ovarian suppression is being administered it can be initiated any time prior to or at the start of protocol therapy, and continued throughout the duration of the trial surgical castration with bilateral oophorectomy must be performed at least 28 days prior to study registration (due to concerns of poor wound healing on bevacizumab)
  • Patients may not have received any prior anti-VEGF or VEGF receptor (VEGFR) tyrosine kinase inhibitor therapy
  • Prior radiotherapy must have been completed and all toxicities resolved at least two weeks prior to registration
  • Chemotherapy in the adjuvant or neoadjuvant setting is permitted; at least twelve months prior to registration must have elapsed since the completion of adjuvant or neoadjuvant chemotherapy and all toxicities must have resolved; taxane-related neurotoxicity must have resolved to sensory grade < 2 and no motor neuropathy of any grade is allowed
  • Patients may have received one prior chemotherapy regimen for metastatic disease; the final dose of prior chemotherapy must have been administered at least 3 weeks prior to study registration
  • Treatment with bisphosphonates is allowed and recommended as per American Society of Clinical Oncology (ASCO) guidelines
  • Patients must not have had a major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study registration, and must have fully recovered from any such procedure
  • Patients must not have anticipation of need for major surgical procedure during the course of the study
  • Patients must not have had a core biopsy or other minor surgical procedure, within 7 days prior to study registration; placement of a vascular access device is allowed within 7 days of registration
  • Patients must not have a history of abdominal fistula, or intra-abdominal abscess within 6 months prior to study registration
  • Patients with a history of gastrointestinal (GI) perforation within 12 months prior to registration are not eligible
  • Patients with a history of significant bleeding episodes (e.g., hemoptysis, upper or lower GI bleeding) within 6 months prior to registration are not eligible
  • Patients must not have clinically significant cardiovascular disease that includes the following:

    • Uncontrolled hypertension defined as systolic blood pressure > 150 and/or diastolic blood pressure > 90 mmHg on antihypertensive medications or any prior history of hypertensive crisis or hypertensive encephalopathy
    • History of myocardial infarction or unstable angina within past 6 months
    • New York Heart Association (NYHA) grade 2 or greater congestive heart failure
    • Symptomatic peripheral vascular disease
    • Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or arterial thrombotic events
  • Full dose anticoagulation therapy is allowed for the treatment of prior conditions such as venous thromboses or atrial fibrillation, but not for the treatment of prior arterial thrombotic events; patients on full dose anticoagulants must be on a stable dose of warfarin and have an in-range international normalized ratio (INR) (usually between 2 and 3) or be on a stable dose of low-molecular weight (LMW) heparin; patients receiving antiplatelet agents are eligible, as are patients on daily prophylactic aspirin or anticoagulation for atrial fibrillation
  • Patients may not have a history of stroke or transient ischemic attack within 6 months prior to study registration
  • Patients with a history of seizures must be well controlled with standard medication
  • Patients must not have known central nervous system (CNS) metastases or leptomeningeal disease (screening with brain imaging is not required for asymptomatic patients)
  • In aromatase inhibitor (AI)-treated patients: no known allergies to imidazole drugs, (e.g. clotrimazole, ketoconazole, miconazole, econazole, sulconazole, ticonazole, or terconazole) or compounds structurally similar to bevacizumab
  • In tamoxifen treated patients: no known allergies to selective estrogen receptor modulators (e.g. tamoxifen, raloxifene or toremilfene) or compounds structurally similar to bevacizumab; for patients enrolled after Update #5, endocrine therapy will consist of letrozole only and this criterion will no longer apply
  • Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1
  • No serious, non-healing wound, ulcer, or bone fracture
  • Life expectancy of >= 12 weeks
  • All patients who are premenopausal (if not already receiving ovarian suppression therapy/surgical oophorectomy) must have a negative beta-human chorionic gonadotropin (beta-Hcg) prior to starting on study treatment; patients may not be pregnant or nursing at any time during the study; ovarian suppression is required in women of childbearing potential by the start of protocol therapy, and will continue for the duration of protocol therapy
  • Granulocytes >= 1,000/μl
  • Platelet count >= 100,000/μl
  • Creatinine =< 2.0 mg/dL
  • Bilirubin =< 1.5 times upper limit of normal (ULN) unless due to Gilbert's syndrome
  • Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 times ULN
  • International normalized ratio (INR) =< 1.6, unless on full dose warfarin
  • Beta-Hcg negative in premenopausal women
  • Urinalysis =< 1+ protein OR urine to plasma creatinine (UPC) < 1

    • Patients discovered to have > 2+ proteinuria at baseline must undergo a 24-hour urine collection that must demonstrate < 1 g of protein/24 hr, or UPC ratio < 1 to allow participation in the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00601900

  Hide Study Locations
Locations
United States, Alabama
Providence Hospital
Mobile, Alabama, United States, 36608
United States, Arkansas
Sparks Regional Medical Center
Fort Smith, Arkansas, United States, 72901
United States, California
East Bay Medical Oncology Hematology Medical Associates-Antioch
Antioch, California, United States, 94531
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States, 94704
Roy and Patricia Disney Family Cancer Center
Burbank, California, United States, 91505
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, United States, 91505
Mills - Peninsula Hospitals
Burlingame, California, United States, 94010
East Bay Radiation Oncology Center
Castro Valley, California, United States, 94546
Eden Hospital Medical Center
Castro Valley, California, United States, 94546
Valley Medical Oncology Consultants-Castro Valley
Castro Valley, California, United States, 94546
Northbay Cancer Center
Fairfield, California, United States, 94533
Valley Medical Oncology Consultants-Fremont
Fremont, California, United States, 94538
California Cancer Center - North Fresno
Fresno, California, United States, 93720
Marin General Hospital
Greenbrae, California, United States, 94904
Los Angeles County-USC Medical Center
Los Angeles, California, United States, 90033
University of Southern California/Norris Cancer Center
Los Angeles, California, United States, 90033
Contra Costa Regional Medical Center
Martinez, California, United States, 94553-3156
Fremont - Rideout Cancer Center
Marysville, California, United States, 95901
El Camino Hospital
Mountain View, California, United States, 94040
Sutter Cancer Research Consortium
Novato, California, United States, 94945
Larry G Strieff MD Medical Corporation
Oakland, California, United States, 94609
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States, 94609
Bay Area Tumor Institute CCOP
Oakland, California, United States, 94609
Bay Area Breast Surgeons Inc
Oakland, California, United States, 94609
Highland General Hospital
Oakland, California, United States, 94602
Tom K Lee Inc
Oakland, California, United States, 94609
University of California Medical Center At Irvine-Orange Campus
Orange, California, United States, 92868
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
Pleasant Hill, California, United States, 94523
Diablo Valley Oncology and Hematology Medical Group-Pleasant Hill
Pleasant Hill, California, United States, 94523
Valley Medical Oncology Consultants
Pleasanton, California, United States, 94588
Valley Care Health System - Pleasanton
Pleasanton, California, United States, 94588
Pomona Valley Hospital Medical Center
Pomona, California, United States, 91767
University of California at Davis Cancer Center
Sacramento, California, United States, 95817
Saint Helena Hospital
Saint Helena, California, United States, 94574
San Francisco General Hospital
San Francisco, California, United States, 94110
UCSF-Mount Zion
San Francisco, California, United States, 94115
California Pacific Medical Center
San Francisco, California, United States, 94118
East Bay Medical Oncology Hematology Associates Inc
San Leandro, California, United States, 94578
Doctors Medical Center- JC Robinson Regional Cancer Center
San Pablo, California, United States, 94806
Tahoe Forest Cancer Center
Truckee, California, United States, 96161
Sutter Solano Medical Center
Vallejo, California, United States, 94589
United States, Colorado
The Medical Center of Aurora
Aurora, Colorado, United States, 80012
Boulder Community Hospital
Boulder, Colorado, United States, 80301
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States, 80907
Colorado Cancer Research Program CCOP
Denver, Colorado, United States, 80224-2522
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, United States, 80218
Rose Medical Center
Denver, Colorado, United States, 80220
Exempla Saint Joseph Hospital
Denver, Colorado, United States, 80218
Swedish Medical Center
Englewood, Colorado, United States, 80113
Front Range Cancer Specialists
Fort Collins, Colorado, United States, 80528
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, United States, 81502
North Colorado Medical Center
Greeley, Colorado, United States, 80631
Saint Anthony Hospital
Lakewood, Colorado, United States, 80228
Littleton Adventist Hospital
Littleton, Colorado, United States, 80122
Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
Longmont United Hospital
Longmont, Colorado, United States, 80501
McKee Medical Center
Loveland, Colorado, United States, 80539
Saint Mary Corwin Medical Center
Pueblo, Colorado, United States, 81004
North Suburban Medical Center
Thornton, Colorado, United States, 80229
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
Hartford Hospital
Hartford, Connecticut, United States, 06102
Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States, 06105
Middlesex Hospital
Middletown, Connecticut, United States, 06457
The Hospital of Central Connecticut
New Britain, Connecticut, United States, 06050
Yale University
New Haven, Connecticut, United States, 06520
Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut, United States, 06904
United States, Delaware
Beebe Medical Center
Lewes, Delaware, United States, 19958
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
United States, District of Columbia
Sibley Memorial Hospital
Washington, District of Columbia, United States, 20016
United States, Florida
Boca Raton Regional Hospital
Boca Raton, Florida, United States, 33486
Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Gainesville Hematology Oncology Associates
Gainesville, Florida, United States, 32605
Jupiter Medical Center
Jupiter, Florida, United States, 33458
Mount Sinai Medical Center CCOP
Miami Beach, Florida, United States, 33140
United States, Georgia
University Cancer and Blood Center LLC
Athens, Georgia, United States, 30607
Northside Hospital
Atlanta, Georgia, United States, 30342
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Atlanta Regional CCOP
Atlanta, Georgia, United States, 30342
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, United States, 30342
Georgia Regents University
Augusta, Georgia, United States, 30912
Well Star Cobb Hospital
Austell, Georgia, United States, 30106
John B Amos Cancer Center
Columbus, Georgia, United States, 31904
Dekalb Medical Center
Decatur, Georgia, United States, 30033
Dublin Hematology Oncology Care PC
Dublin, Georgia, United States, 31021
Piedmont Fayette Hospital
Fayetteville, Georgia, United States, 30214
Eisenhower Army Medical Center
Fort Gordon, Georgia, United States, 30905-5650
Northeast Georgia Medical Center
Gainesville, Georgia, United States, 30501
Gwinnett Medical Center
Lawrenceville, Georgia, United States, 30045
Medical Center of Central Georgia
Macon, Georgia, United States, 31208
Wellstar Kennestone Hospital
Marietta, Georgia, United States, 30060
Southern Regional Medical Center
Riverdale, Georgia, United States, 30274
Harbin Clinic Medical Oncology and Clinical Research
Rome, Georgia, United States, 30165
United States, Illinois
Rush - Copley Medical Center
Aurora, Illinois, United States, 60504
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States, 61701
Saint Joseph Medical Center
Bloomington, Illinois, United States, 61701
Graham Hospital Association
Canton, Illinois, United States, 61520
Illinois CancerCare-Canton
Canton, Illinois, United States, 61520
Illinois CancerCare-Carthage
Carthage, Illinois, United States, 62321
Memorial Hospital
Carthage, Illinois, United States, 62321
Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
University of Chicago
Chicago, Illinois, United States, 60637
Resurrection Healthcare
Chicago, Illinois, United States, 60631
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States, 60612-3785
Mount Sinai Hospital Medical Center
Chicago, Illinois, United States, 60608
Mercy Hospital and Medical Center
Chicago, Illinois, United States, 60616
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Alexian Brothers Medical and Cancer Center
Elk Grove Village, Illinois, United States, 60007
Elmhurst Memorial Hospital
Elmhurst, Illinois, United States, 60126
Eureka Hospital
Eureka, Illinois, United States, 61530
Illinois CancerCare-Eureka
Eureka, Illinois, United States, 61530
FHN Leonard C. Ferguson Cancer Center
Freeport, Illinois, United States, 61032
Illinois CancerCare Galesburg
Galesburg, Illinois, United States, 61401
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Mason District Hospital
Havana, Illinois, United States, 62644
Illinois CancerCare-Havana
Havana, Illinois, United States, 62644
Joliet Oncology-Hematology Associates Limited
Joliet, Illinois, United States, 60435
Presence Saint Mary's Hospital
Kankakee, Illinois, United States, 60901
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, United States, 61443
Illinois CancerCare-Macomb
Macomb, Illinois, United States, 61455
Mcdonough District Hospital
Macomb, Illinois, United States, 61455
Sharis, Christine M MD (UIA Investigator)
Moline, Illinois, United States, 61265
Stoffel, Thomas J MD (UIA Investigator)
Moline, Illinois, United States, 61265
Porubcin, Michael MD (UIA Investigator)
Moline, Illinois, United States, 61265
Spector, David MD (UIA Investigator)
Moline, Illinois, United States, 61265
Garneau, Stewart C MD (UIA Investigator)
Moline, Illinois, United States, 61265
Trinity Medical Center
Moline, Illinois, United States, 61265
Holy Family Medical Center
Monmouth, Illinois, United States, 61462
Illinois CancerCare-Monmouth
Monmouth, Illinois, United States, 61462
Hematology Oncology Consultants Limited
Naperville, Illinois, United States, 60540
Illinois CancerCare-Community Cancer Center
Normal, Illinois, United States, 61761
Bromenn Regional Medical Center
Normal, Illinois, United States, 61761
Community Cancer Center Foundation
Normal, Illinois, United States, 61761
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States, 61350
Ottawa Regional Hospital and Healthcare Center
Ottawa, Illinois, United States, 61350
Illinois CancerCare-Pekin
Pekin, Illinois, United States, 61554
Pekin Cancer Treatment Center
Pekin, Illinois, United States, 61554
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61603
Illinois Oncology Research Association CCOP
Peoria, Illinois, United States, 61615
Proctor Hospital
Peoria, Illinois, United States, 61614
Illinois CancerCare-Peoria
Peoria, Illinois, United States, 61615
Illinois Valley Hospital
Peru, Illinois, United States, 61354
Illinois CancerCare-Peru
Peru, Illinois, United States, 61354
Perry Memorial Hospital
Princeton, Illinois, United States, 61356
Illinois CancerCare-Princeton
Princeton, Illinois, United States, 61356
Illinois CancerCare-Spring Valley
Spring Valley, Illinois, United States, 61362
Memorial Medical Center
Springfield, Illinois, United States, 62781-0001
Carle Clinic-Urbana Main
Urbana, Illinois, United States, 61801
Carle Cancer Center
Urbana, Illinois, United States, 61801
United States, Indiana
Elkhart Clinic
Elkhart, Indiana, United States, 46514-2098
Elkhart General Hospital
Elkhart, Indiana, United States, 46515
Michiana Hematology Oncology PC-Elkhart
Elkhart, Indiana, United States, 46514
Fort Wayne Medical Oncology and Hematology Inc-Parkview
Fort Wayne, Indiana, United States, 46845
Saint Vincent Hospital and Health Services
Indianapolis, Indiana, United States, 46260
Community Howard Regional Health
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital
La Porte, Indiana, United States, 46350
IU Health Arnett
Lafayette, Indiana, United States, 47904
Franciscan Saint Anthony Health-Michigan City
Michigan City, Indiana, United States, 46360
Michiana Hematology Oncology PC-Mishawaka
Mishawaka, Indiana, United States, 46545-1470
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka, Indiana, United States, 46545-1470
Michiana Hematology Oncology PC-Plymouth
Plymouth, Indiana, United States, 46563
Michiana Hematology Oncology PC-South Bend
South Bend, Indiana, United States, 46601
Memorial Hospital of South Bend
South Bend, Indiana, United States, 46601
Northern Indiana Cancer Research Consortium
South Bend, Indiana, United States, 46628
Michiana Hematology Oncology-PC Westville
Westville, Indiana, United States, 46391
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center
Ames, Iowa, United States, 50010
Hematology Oncology Associates-Quad Cities
Bettendorf, Iowa, United States, 52722
Constantinou, Costas L MD (UIA Investigator)
Bettendorf, Iowa, United States, 52722
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, United States, 50325
Iowa Oncology Research Association CCOP
Des Moines, Iowa, United States, 50309
Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, United States, 50314
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Mercy Capitol
Des Moines, Iowa, United States, 50307
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
Mercy Medical Center-Sioux City
Sioux City, Iowa, United States, 51104
Saint Luke's Regional Medical Center
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates
Sioux City, Iowa, United States, 51101
United States, Kansas
Hays Medical Center
Hays, Kansas, United States, 67601
Promise Regional Medical Center-Hutchinson
Hutchinson, Kansas, United States, 65702
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Olathe Cancer Center
Olathe, Kansas, United States, 66061
Via Christi Hospital-Pittsburg
Pittsburg, Kansas, United States, 66762
Salina Regional Health Center
Salina, Kansas, United States, 67401
Stormont-Vail Regional Health Center
Topeka, Kansas, United States, 66604
Saint Francis Hospital and Medical Center - Topeka
Topeka, Kansas, United States, 66606
United States, Kentucky
Our Lady Bellefonte Hospital
Ashland, Kentucky, United States, 41101
Doctors Carrol, Sheth, Raghavan
Louisville, Kentucky, United States, 40215
United States, Louisiana
Hematology/Oncology Clinic LLP
Baton Rouge, Louisiana, United States, 70809
Ochsner Health Center-Summa
Baton Rouge, Louisiana, United States, 70809
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809
Ochsner Health Center-Covington
Covington, Louisiana, United States, 70433
Ochsner Baptist Medical Center
New Orleans, Louisiana, United States, 70115
Tulane University Health Sciences Center
New Orleans, Louisiana, United States, 70112
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Ochsner Clinic CCOP
New Orleans, Louisiana, United States, 70121
United States, Maine
Harold Alfond Center for Cancer Care
Augusta, Maine, United States, 04330
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Maine Center for Cancer Medicine and Blood Disorders-Scarborough
Scarborough, Maine, United States, 04074
United States, Maryland
Veterans Administration Medical Center-Baltimore
Baltimore, Maryland, United States, 21201
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States, 21201
Union Hospital of Cecil County
Elkton MD, Maryland, United States, 21921
Frederick Memorial Hospital
Frederick, Maryland, United States, 21701
Kaiser Permanente - Largo Medical Center
Largo, Maryland, United States, 20774
Kaiser Permanente - Towson Medical Center
Lutherville, Maryland, United States, 21093
Kaiser Permanente - Shady Grove Medical Center
Rockville, Maryland, United States, 20850
Holy Cross Hospital
Silver Spring, Maryland, United States, 20910
United States, Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Cape Cod Hospital
Hyannis, Massachusetts, United States, 02601
Lowell General Hospital
Lowell, Massachusetts, United States, 01854
Holy Family Hospital
Methuen, Massachusetts, United States, 01844
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford, Massachusetts, United States, 01757
Newton-Wellesley Hospital
Newton, Massachusetts, United States, 02462
United States, Michigan
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106-0995
Michigan Cancer Research Consortium Community Clinical Oncology Program
Ann Arbor, Michigan, United States, 48106
McLaren-Bay Region
Bay City, Michigan, United States, 48708
Oakwood Hospital
Dearborn, Michigan, United States, 48124
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Saint John Hospital and Medical Center
Detroit, Michigan, United States, 48236
Michigan State University Clinical Center
East Lansing, Michigan, United States, 48824-7016
Green Bay Oncology - Escanaba
Escanaba, Michigan, United States, 49431
Hurley Medical Center
Flint, Michigan, United States, 48502
Genesys Regional Medical Center-West Flint Campus
Flint, Michigan, United States, 48532
McLaren-Flint
Flint, Michigan, United States, 48532
Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, United States, 49503
Green Bay Oncology - Iron Mountain
Iron Mountain, Michigan, United States, 49801
Allegiance Health
Jackson, Michigan, United States, 49201
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center
Kalamazoo, Michigan, United States, 49001
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
McLaren-Greater Lansing
Lansing, Michigan, United States, 48910
Sparrow Hospital
Lansing, Michigan, United States, 48912
Saint Mary Mercy Hospital
Livonia, Michigan, United States, 48154
Marquette General Hospital
Marquette, Michigan, United States, 49855
Mid-Michigan Medical Center - Midland
Midland, Michigan, United States, 48670
Mercy Health Partners-Hackley Campus
Muskegon, Michigan, United States, 49442
Michiana Hematology Oncology PC-Niles
Niles, Michigan, United States, 49120
Northern Michigan Regional Hospital
Petoskey, Michigan, United States, 49770
Saint Joseph Mercy Oakland
Pontiac, Michigan, United States, 48341-2985
Saint Joseph Mercy Port Huron
Port Huron, Michigan, United States, 48060
Saint Mary's of Michigan
Saginaw, Michigan, United States, 48601
Marie Yeager Cancer Center
Saint Joseph, Michigan, United States, 49085
Providence Hospital
Southfield, Michigan, United States, 48075
Lakeland Hospital
St. Joseph, Michigan, United States, 49085
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States, 48093
United States, Minnesota
Medini, Eitan MD (UIA Investigator)
Alexandria, Minnesota, United States, 56308
Essentia Health Duluth Clinic CCOP
Duluth, Minnesota, United States, 55805
Miller-Dwan Hospital
Duluth, Minnesota, United States, 55805
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, United States, 55805
Swenson, Wade II, MD (UIA Investigator)
Fergus Falls, Minnesota, United States, 56537
Etzell, Paul S MD (UIA Investigator)
Fergus Falls, Minnesota, United States, 56537
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States, 56001
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
Saint Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Singing River Hospital
Pascagoula, Mississippi, United States, 39581
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center
Bolivar, Missouri, United States, 65613
CoxHealth Cancer Center
Branson, Missouri, United States, 65616
Southeast Cancer Center
Cape Girardeau, Missouri, United States, 63703
Southeast Missouri Hospital
Cape Girardeau, Missouri, United States, 63701
University of Missouri - Ellis Fischel
Columbia, Missouri, United States, 65212
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City, Missouri, United States, 65109
Freeman Health System
Joplin, Missouri, United States, 64804
Truman Medical Center
Kansas City, Missouri, United States, 64108
Phelps County Regional Medical Center
Rolla, Missouri, United States, 65401
Missouri Baptist Medical Center
Saint Louis, Missouri, United States, 63131
Comprehensive Cancer Care PC
Saint Louis, Missouri, United States, 63141
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
CoxHealth South Hospital
Springfield, Missouri, United States, 65807
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield
Springfield, Missouri, United States, 65804
United States, Montana
Billings Clinic
Billings, Montana, United States, 59107-7000
Saint Vincent Healthcare
Billings, Montana, United States, 59101
Montana Cancer Consortium CCOP
Billings, Montana, United States, 59101
Northern Rockies Radiation Oncology Center
Billings, Montana, United States, 59101
Hematology-Oncology Centers of the Northern Rockies PC
Billings, Montana, United States, 59102
Bozeman Deaconess Cancer Center
Bozeman, Montana, United States, 59715
Bozeman Deaconess Hospital
Bozeman, Montana, United States, 59715
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, United States, 59701
Great Falls Clinic
Great Falls, Montana, United States, 59405
Berdeaux, Donald MD (UIA Investigator)
Great Falls, Montana, United States, 59405
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Big Sky Oncology
Great Falls, Montana, United States, 59405
Northern Montana Hospital
Havre, Montana, United States, 59501
Saint Peter's Community Hospital
Helena, Montana, United States, 59601
Kalispell Medical Oncology
Kalispell, Montana, United States, 59901
Glacier Oncology PLLC
Kalispell, Montana, United States, 59901
Kalispell Regional Medical Center
Kalispell, Montana, United States, 59901
Community Medical Hospital
Missoula, Montana, United States, 59801
Saint Patrick Hospital - Community Hospital
Missoula, Montana, United States, 59802
Montana Cancer Specialists
Missoula, Montana, United States, 59802
Guardian Oncology and Center for Wellness
Missoula, Montana, United States, 59804
United States, Nebraska
Saint Francis Medical Center
Grand Island, Nebraska, United States, 68803
Nebraska Cancer Research Center
Lincoln, Nebraska, United States, 68510
Great Plains Regional Medical Center
North Platte, Nebraska, United States, 69103
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Missouri Valley Cancer Consortium CCOP
Omaha, Nebraska, United States, 68106
Creighton University Medical Center
Omaha, Nebraska, United States, 68131
Alegent Health Immanuel Medical Center
Omaha, Nebraska, United States, 68122
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
United States, New Hampshire
New Hampshire Oncology-Hematology PA
Concord, New Hampshire, United States, 03301
New Hampshire Oncology Hematology Associates
Hooksett, New Hampshire, United States, 03106
Cheshire Medical Center-Dartmouth-Hitchcock Keene
Keene, New Hampshire, United States, 03431
LRGHealthcare-Lakes Region General Hospital
Laconia, New Hampshire, United States, 03246
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Saint Joseph Hospital
Nashua, New Hampshire, United States, 03060
United States, New Jersey
Cooper Hospital University Medical Center
Camden, New Jersey, United States, 08103
CentraState Medical Center
Freehold, New Jersey, United States, 07728
Hackensack University Medical CCOP
Hackensack, New Jersey, United States, 07601
Morristown Memorial Hospital
Morristown, New Jersey, United States, 07962
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Overlook Hospital
Summit, New Jersey, United States, 07902
Inspira Medical Center Vineland
Vineland, New Jersey, United States, 08360
United States, New York
Albert Einstein College of Medicine
Bronx, New York, United States, 10461
Montefiore Medical Center - Moses Campus
Bronx, New York, United States, 10467-2490
Hematology Oncology Associates of Central New York PC-East Syracuse
East Syracuse, New York, United States, 13057
Elmhurst Hospital Center
Elmhurst, New York, United States, 11373
Arnot Ogden Medical Center
Elmira, New York, United States, 14905
Adirondack Cancer Center
Glens Falls, New York, United States, 12801
Queens Hospital Center
Jamaica, New York, United States, 11432
Beth Israel Medical Center
New York, New York, United States, 10003
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065
Columbia University Medical Center
New York, New York, United States, 10032
Saint Vincent's Hospital and Medical Center of New York
New York, New York, United States, 10011
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division
New York, New York, United States, 10025
Weill Medical College of Cornell University
New York, New York, United States, 10065
Staten Island University Hospital
Staten Island, New York, United States, 10305
Faxton-Saint Luke's Healthcare
Utica, New York, United States, 13502
United States, North Carolina
Randolph Hospital
Asheboro, North Carolina, United States, 27203
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Wayne Memorial Hospital
Goldsboro, North Carolina, United States, 27534
Cone Health Cancer Center
Greensboro, North Carolina, United States, 27403
Kinston Medical Specialists PA
Kinston, North Carolina, United States, 28501
Annie Penn Memorial Hospital
Reidsville, North Carolina, United States, 27320
Rutherford Hospital
Rutherfordton, North Carolina, United States, 28139
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
Saint Alexius Medical Center
Bismarck, North Dakota, United States, 58501
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Mid Dakota Clinic
Bismarck, North Dakota, United States, 58501
Bismarck Cancer Center
Bismarck, North Dakota, United States, 58501
Altru Cancer Center
Grand Forks, North Dakota, United States, 58201
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
United States, Ohio
Mary Rutan Hospital
Bellefontaine, Ohio, United States, 43311
Aultman Health Foundation
Canton, Ohio, United States, 44710
Adena Regional Medical Center
Chillicothe, Ohio, United States, 45601
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Ohio State University Medical Center
Columbus, Ohio, United States, 43210
Columbus CCOP
Columbus, Ohio, United States, 43215
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus, Ohio, United States, 43210
Doctors Hospital
Columbus, Ohio, United States, 43228
Grant Medical Center
Columbus, Ohio, United States, 43215
Mount Carmel Health Center West
Columbus, Ohio, United States, 43222
Riverside Methodist Hospital
Columbus, Ohio, United States, 43214
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Fairfield Medical Center
Lancaster, Ohio, United States, 43130
Saint Rita's Medical Center
Lima, Ohio, United States, 45801
Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
Knox Community Hospital
Mount Vernon, Ohio, United States, 43050
Licking Memorial Hospital
Newark, Ohio, United States, 43055
Southern Ohio Medical Center
Portsmouth, Ohio, United States, 45662
Springfield Regional Medical Center
Springfield, Ohio, United States, 45505
Saint Ann's Hospital
Westerville, Ohio, United States, 43081
Genesis HealthCare System
Zanesville, Ohio, United States, 43701
United States, Oregon
Saint Charles Medical Center-Bend
Bend, Oregon, United States, 97701
Clackamas Radiation Oncology Center
Clackamas, Oregon, United States, 97015
Providence Milwaukie Hospital
Milwaukie, Oregon, United States, 97222
Providence Newberg Medical Center
Newberg, Oregon, United States, 97132
Providence Willamette Falls Medical Center
Oregon City, Oregon, United States, 97045
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center
Portland, Oregon, United States, 97225
Western Oncology Research Consortium
Portland, Oregon, United States, 97213
Adventist Medical Center
Portland, Oregon, United States, 97216
Kaiser Permanente
Portland, Oregon, United States, 97227
United States, Pennsylvania
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18105
Doylestown Hospital
Doylestown, Pennsylvania, United States, 18901
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15232
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, United States, 18840
Scranton Hematology Oncology
Scranton, Pennsylvania, United States, 18510
Mercy Hospital
Scranton, Pennsylvania, United States, 18501
Grand View Hospital
Sellersville, Pennsylvania, United States, 18960
Chester County Hospital
West Chester, Pennsylvania, United States, 19380
Reading Hospital
West Reading, Pennsylvania, United States, 19611
United States, Rhode Island
Hematology and Oncology Associates of Rhode Island Inc
Cranston, Rhode Island, United States, 02920
Kent County Hospital
Warwick, Rhode Island, United States, 02886
United States, South Carolina
AnMed Health Cancer Center
Anderson, South Carolina, United States, 29621
AnMed Health Hospital
Anderson, South Carolina, United States, 29621
McLeod Regional Medical Center
Florence, South Carolina, United States, 29506
Saint Francis Hospital
Greenville, South Carolina, United States, 29601
Spartanburg Regional Medical Center
Spartanburg, South Carolina, United States, 29303
Upstate Carolina CCOP
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Conklin Regional Cancer Center
Aberdeen, South Dakota, United States, 57401
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, United States, 57105
Medical X-Ray Center
Sioux Falls, South Dakota, United States, 57105
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Sanford Cancer Center-Oncology Clinic
Sioux Falls, South Dakota, United States, 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
United States, Tennessee
Erlanger Medical Center
Chattanooga, Tennessee, United States, 37403
United States, Texas
Doctor's Hospital of Laredo
Laredo, Texas, United States, 78041
United States, Virginia
Danville Regional Medical Center
Danville, Virginia, United States, 24541
Kaiser Permanente - Fair Oaks Medical Center
Fairfax, Virginia, United States, 22033
United States, Washington
Providence Holy Family Hospital
Spokane, Washington, United States, 99208
Rockwood Clinic
Spokane, Washington, United States, 99220
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
PeaceHealth Southwest Medical Center
Vancouver, Washington, United States, 98664
United States, West Virginia
West Virginia University Charleston
Charleston, West Virginia, United States, 25304
The Schiffler Cancer Center of Wheeling Hospital
Wheeling, West Virginia, United States, 26003
Wheeling Hospital
Wheeling, West Virginia, United States, 26003
United States, Wisconsin
Aurora Cancer Care-Burlington
Burlington, Wisconsin, United States, 53105
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, United States, 54729
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, Wisconsin, United States, 54701
Aurora Cancer Care-Southern Lakes
Elkhorn, Wisconsin, United States, 53121
Aurora Cancer Care-Franklin
Franklin, Wisconsin, United States, 53132
Aurora Cancer Care-Glendale
Glendale, Wisconsin, United States, 53212
Bellin Memorial Hospital
Green Bay, Wisconsin, United States, 54301
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311-6519
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Saint Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Saint Vincent Hospital
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology at Saint Vincent Hospital
Green Bay, Wisconsin, United States, 54301-3526
Mercy Health System
Janesville, Wisconsin, United States, 53547
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, United States, 53142
Gundersen Lutheran
La Crosse, Wisconsin, United States, 54601
Dean Hematology and Oncology Clinic
Madison, Wisconsin, United States, 53717
Holy Family Memorial Hospital
Manitowoc, Wisconsin, United States, 54221
Vince Lombardi Cancer Clinic-Marinette
Marinette, Wisconsin, United States, 54143
Bay Area Medical Center
Marinette, Wisconsin, United States, 54143
Saint Joseph's Hospital
Marshfield, Wisconsin, United States, 54449
Marshfield Clinic
Marshfield, Wisconsin, United States, 54449
Aurora Advanced Healthcare Inc-Mequon
Mequon, Wisconsin, United States, 53092
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Medical Consultants Limited
Milwaukee, Wisconsin, United States, 53215
Aurora Cancer Care-Milwaukee South
Milwaukee, Wisconsin, United States, 53215
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, United States, 54548
Oconomowoc Memorial Hospital-ProHealth Care Inc
Oconomowoc, Wisconsin, United States, 53066-3896
Green Bay Oncology - Oconto Falls
Oconto Falls, Wisconsin, United States, 54154
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Aurora Cancer Care-Racine
Racine, Wisconsin, United States, 53406-5661
Marshfield Clinic at James Beck Cancer Center
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic-Rice Lake Center
Rice Lake, Wisconsin, United States, 54868
Saint Nicholas Hospital
Sheboygan, Wisconsin, United States, 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, United States, 53081
Marshfield Clinic Cancer Care at Saint Michael's Hospital
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235
Aurora Medical Center in Summit
Summit, Wisconsin, United States, 53066
Vince Lombardi Cancer Clinic
Two Rivers, Wisconsin, United States, 54241
Aurora Cancer Care-Waukesha
Waukesha, Wisconsin, United States, 53188
Waukesha Memorial Hospital - ProHealth Care
Waukesha, Wisconsin, United States, 53188
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, United States, 53226
Marshfield Clinic - Weston Center
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, United States, 54494
Riverview Hospital
Wisconsin Rapids, Wisconsin, United States, 54494
United States, Wyoming
Rocky Mountain Oncology
Casper, Wyoming, United States, 82609
Welch Cancer Center
Sheridan, Wyoming, United States, 82801
Puerto Rico
San Juan City Hospital
San Juan, Puerto Rico, 00936
Sponsors and Collaborators
Investigators
Principal Investigator: Maura Dickler Cancer and Leukemia Group B
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00601900     History of Changes
Other Study ID Numbers: NCI-2009-00477, NCI-2009-00477, CDR0000584091, CALGB-40503, CALGB 40503, CALGB-40503, P30CA014236, U10CA031946
Study First Received: January 18, 2008
Last Updated: July 23, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases
Antibodies
Antibodies, Monoclonal
Citric Acid
Tamoxifen
Letrozole
Bevacizumab
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Anticoagulants
Hematologic Agents
Therapeutic Uses
Chelating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Selective Estrogen Receptor Modulators
Estrogen Receptor Modulators
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Bone Density Conservation Agents
Estrogen Antagonists
Aromatase Inhibitors
Enzyme Inhibitors
Angiogenesis Inhibitors

ClinicalTrials.gov processed this record on July 23, 2014