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| Sponsor: | Pfizer |
|---|---|
| Information provided by: | Pfizer |
| ClinicalTrials.gov Identifier: | NCT00596830 |
Purpose
Determine whether the addition of CP 751,871 in combination with paclitaxel plus carboplatin prolongs survival in patients with locally advanced (Stage IIIB with pleural effusion) or metastatic (Stage IV or recurrent) NSCLC of non adenocarcinoma histology.
| Condition | Intervention | Phase |
|---|---|---|
|
Carcinoma, Squamous Cell Carcinoma, Adenosquamous Carcinoma, Large Cell Carcinoma, Non-Small-Cell Lung |
Drug: CP-751,871 + Carboplatin +Paclitaxel Drug: Carboplatin + Paclitaxel |
Phase III |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Open Label, Parallel Assignment, Safety/Efficacy Study |
| Official Title: | Randomized, Open Label, Phase III Trial Of CP- 751,871 In Combination With Paclitaxel And Carboplatin Versus Paclitaxel And Carboplatin In Patients With Non Small Cell Lung Cancer |
| Estimated Enrollment: | 820 |
| Study Start Date: | March 2008 |
| Estimated Study Completion Date: | July 2011 |
| Estimated Primary Completion Date: | July 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
A: Experimental
Patients in Arm A will receive CP-751, 871 in combination with paclitaxel and carboplatin intravenously every 21 days for up to six cycles.`
|
Drug: CP-751,871 + Carboplatin +Paclitaxel
CP 751,871 is a potent and selective fully human monoclonal antibody against the insulin like growth factor 1 receptor (IGF-1R). Carboplatin is a standard chemotherapeutic agent used in patients with lung cancer. Paclitaxel is a standard chemotherapeutic agent used in patients with lung cancer. |
|
B: Active Comparator
Patient in Arm B will receive paclitaxel and carboplatin intravenously every 21 days for up to six cycles.
|
Drug: Carboplatin + Paclitaxel
Carboplatin is a standard chemotherapeutic agent used in patients with lung cancer
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations
Hide Study Locations| United States, Alabama | |
| Pfizer Investigational Site | |
| Florence, Alabama, United States, 35630 | |
| Pfizer Investigational Site | |
| Muscle Shoals, Alabama, United States, 35661 | |
| Pfizer Investigational Site | |
| Huntsville, Alabama, United States, 35805 | |
| United States, Arizona | |
| Pfizer Investigational Site | |
| Phoenix, Arizona, United States, 85012 | |
| Pfizer Investigational Site | |
| Scottsdale, Arizona, United States, 85258 | |
| United States, Arkansas | |
| Pfizer Investigational Site | |
| Fort Smith, Arkansas, United States, 72903 | |
| Pfizer Investigational Site | |
| Hot Springs, Arkansas, United States, 71913 | |
| United States, California | |
| Pfizer Investigational Site | |
| Mather, California, United States, 95655 | |
| Pfizer Investigational Site | |
| Sacramento, California, United States, 95817 | |
| Pfizer Investigational Site | |
| Loma Linda, California, United States, 92354 | |
| United States, Colorado | |
| Pfizer Investigational Site | |
| Aurora, Colorado, United States, 80012 | |
| Pfizer Investigational Site | |
| Denver, Colorado, United States, 80205 | |
| Pfizer Investigational Site | |
| Colorado Springs, Colorado, United States, 80907 | |
| Pfizer Investigational Site | |
| Colorado Springs, Colorado, United States, 80909 | |
| Pfizer Investigational Site | |
| Denver, Colorado, United States, 80218 | |
| Pfizer Investigational Site | |
| Denver, Colorado, United States, 80220 | |
| Pfizer Investigational Site | |
| Lakewood, Colorado, United States, 80228 | |
| Pfizer Investigational Site | |
| Littleton, Colorado, United States, 80120 | |
| Pfizer Investigational Site | |
| Lone Tree, Colorado, United States, 80124 | |
| Pfizer Investigational Site | |
| Longmont, Colorado, United States, 80501 | |
| Pfizer Investigational Site | |
| Parker, Colorado, United States, 80138 | |
| Pfizer Investigational Site | |
| Thornton, Colorado, United States, 80260 | |
| Pfizer Investigational Site | |
| Boulder, Colorado, United States, 80303 | |
| Pfizer Investigational Site | |
| Colorado Springs, Colorado, United States, 80907 | |
| United States, Connecticut | |
| Pfizer Investigational Site | |
| Norwich, Connecticut, United States, 06360 | |
| Pfizer Investigational Site | |
| Norwalk, Connecticut, United States, 06856 | |
| United States, District of Columbia | |
| Pfizer Investigational Site | |
| Washington, District of Columbia, United States, 20007 | |
| Pfizer Investigational Site | |
| Washington, District of Columbia, United States, 20007-2197 | |
| United States, Florida | |
| Pfizer Investigational Site | |
| Hollywood, Florida, United States, 33021 | |
| Pfizer Investigational Site | |
| Pembroke Pines, Florida, United States, 33028 | |
| Pfizer Investigational Site | |
| Jacksonville, Florida, United States, 32205 | |
| Pfizer Investigational Site | |
| Jacksonville, Florida, United States, 32207 | |
| Pfizer Investigational Site | |
| Jacksonville, Florida, United States, 32256 | |
| Pfizer Investigational Site | |
| Jacksonville, Florida, United States, 32258 | |
| Pfizer Investigational Site | |
| Pensacola, Florida, United States, 32514 | |
| Pfizer Investigational Site | |
| Orlando, Florida, United States, 32803 | |
| Pfizer Investigational Site | |
| Port St. Lucie, Florida, United States, 34952 | |
| Pfizer Investigational Site | |
| Lake City, Florida, United States, 32024 | |
| Pfizer Investigational Site | |
| Lake City, Florida, United States, 32055 | |
| Pfizer Investigational Site | |
| Boynton Beach, Florida, United States, 33426 | |
| Pfizer Investigational Site | |
| Lake Worth, Florida, United States, 33461 | |
| Pfizer Investigational Site | |
| Hudson, Florida, United States, 34667 | |
| Pfizer Investigational Site | |
| New Port Richey, Florida, United States, 34655 | |
| Pfizer Investigational Site | |
| Spring Hill, Florida, United States, 34608 | |
| Pfizer Investigational Site | |
| Lakeland, Florida, United States, 33805 | |
| Pfizer Investigational Site | |
| Pensacola, Florida, United States, 32504 | |
| Pfizer Investigational Site | |
| Orlando, Florida, United States, 32804 | |
| Pfizer Investigational Site | |
| Fort Lauderdale, Florida, United States, 33308 | |
| Pfizer Investigational Site | |
| Miami, Florida, United States, 33133 | |
| United States, Georgia | |
| Pfizer Investigational Site | |
| Atlanta, Georgia, United States, 30341 | |
| Pfizer Investigational Site | |
| Atlanta, Georgia, United States, 30342 | |
| Pfizer Investigational Site | |
| Decatur, Georgia, United States, 30033 | |
| Pfizer Investigational Site | |
| Snellville, Georgia, United States, 30078 | |
| Pfizer Investigational Site | |
| Marietta, Georgia, United States, 30060 | |
| Pfizer Investigational Site | |
| Atlanta, Georgia, United States, 30318 | |
| Pfizer Investigational Site | |
| Duluth, Georgia, United States, 30096 | |
| Pfizer Investigational Site | |
| Lawrenceville, Georgia, United States, 30045 | |
| Pfizer Investigational Site | |
| Macon, Georgia, United States, 31217 | |
| Pfizer Investigational Site | |
| Conyers, Georgia, United States, 30094 | |
| Pfizer Investigational Site | |
| Cumming, Georgia, United States, 30041 | |
| Pfizer Investigational Site | |
| Roswell, Georgia, United States, 30076 | |
| Pfizer Investigational Site | |
| Stockbridge, Georgia, United States, 30281 | |
| United States, Idaho | |
| Pfizer Investigational Site | |
| Boise, Idaho, United States, 83712 | |
| Pfizer Investigational Site | |
| Fruitland, Idaho, United States, 83619 | |
| Pfizer Investigational Site | |
| Meridian, Idaho, United States, 83642 | |
| Pfizer Investigational Site | |
| Nampa, Idaho, United States, 83686 | |
| Pfizer Investigational Site | |
| Twin Falls, Idaho, United States, 83301 | |
| Pfizer Investigational Site | |
| Coeur D' Alene, Idaho, United States, 83814 | |
| United States, Illinois | |
| Pfizer Investigational Site | |
| Chicago, Illinois, United States, 60637 | |
| Pfizer Investigational Site | |
| Aurora, Illinois, United States, 60504 | |
| Pfizer Investigational Site | |
| Aurora, Illinois, United States, 61342 | |
| Pfizer Investigational Site | |
| Arlington Heights, Illinois, United States, 60005 | |
| Pfizer Investigational Site | |
| Elk Grove Village, Illinois, United States, 60007 | |
| Pfizer Investigational Site | |
| Galesburg, Illinois, United States, 61401 | |
| Pfizer Investigational Site | |
| Skokie, Illinois, United States, 60076 | |
| Pfizer Investigational Site | |
| Winfield, Illinois, United States, 60190 | |
| United States, Indiana | |
| Pfizer Investigational Site | |
| Avon, Indiana, United States, 46123 | |
| Pfizer Investigational Site | |
| Beech Grove, Indiana, United States, 46107 | |
| Pfizer Investigational Site | |
| Indianapolis, Indiana, United States, 46237 | |
| Pfizer Investigational Site | |
| Indianapolis, Indiana, United States, 46260 | |
| Pfizer Investigational Site | |
| Mooresville, Indiana, United States, 46158 | |
| Pfizer Investigational Site | |
| Mooresville, Indiana, United States, 46158-1737 | |
| Pfizer Investigational Site | |
| Hobart, Indiana, United States, 46342 | |
| Pfizer Investigational Site | |
| Hobart, Indiana, United States, 46432 | |
| Pfizer Investigational Site | |
| Munster, Indiana, United States, 46321 | |
| United States, Iowa | |
| Pfizer Investigational Site | |
| Cedar Rapids, Iowa, United States, 52402 | |
| United States, Kansas | |
| Pfizer Investigational Site | |
| Kansas City, Kansas, United States, 66112 | |
| Pfizer Investigational Site | |
| Overland Park, Kansas, United States, 66210 | |
| United States, Kentucky | |
| Pfizer Investigational Site | |
| Louisville, Kentucky, United States, 40202 | |
| Pfizer Investigational Site | |
| Louisville, Kentucky, United States, 40207 | |
| United States, Louisiana | |
| Pfizer Investigational Site | |
| New Orleans, Louisiana, United States, 70121 | |
| Pfizer Investigational Site | |
| New Orleans, Louisiana, United States, 70112-2699 | |
| United States, Maryland | |
| Pfizer Investigational Site | |
| Baltimore, Maryland, United States, 21237 | |
| Pfizer Investigational Site | |
| Baltimore, Maryland, United States, 21225 | |
| Pfizer Investigational Site | |
| Bethesda, Maryland, United States, 20817 | |
| United States, Massachusetts | |
| Pfizer Investigational Site | |
| Lawrence, Massachusetts, United States, 01842 | |
| Pfizer Investigational Site | |
| Quincy, Massachusetts, United States, 02169 | |
| Pfizer Investigational Site | |
| Stoneham, Massachusetts, United States, 02180 | |
| Pfizer Investigational Site | |
| Weymouth, Massachusetts, United States, 02189 | |
| Pfizer Investigational Site | |
| Worcester, Massachusetts, United States, 01605 | |
| Pfizer Investigational Site | |
| Boston, Massachusetts, United States, 02114 | |
| Pfizer Investigational Site | |
| Boston, Massachusetts, United States, 02115 | |
| Pfizer Investigational Site | |
| Boston, Massachusetts, United States, 02215 | |
| United States, Michigan | |
| Pfizer Investigational Site | |
| Detroit, Michigan, United States, 48201 | |
| Pfizer Investigational Site | |
| Farmington Hills, Michigan, United States, 48334 | |
| Pfizer Investigational Site | |
| St. Joseph, Michigan, United States, 49085 | |
| Pfizer Investigational Site | |
| Petoskey, Michigan, United States, 49770 | |
| United States, Minnesota | |
| Pfizer Investigational Site | |
| St. Louis Park, Minnesota, United States, 55416 | |
| Pfizer Investigational Site | |
| St. Louis Park, Minnesota, United States, 55426 | |
| Pfizer Investigational Site | |
| Burnsville, Minnesota, United States, 55337 | |
| Pfizer Investigational Site | |
| Woodbury, Minnesota, United States, 55125 | |
| Pfizer Investigational Site | |
| Maplewood, Minnesota, United States, 55109 | |
| Pfizer Investigational Site | |
| Minneapolis, Minnesota, United States, 55404 | |
| Pfizer Investigational Site | |
| St. Paul, Minnesota, United States, 55102 | |
| Pfizer Investigational Site | |
| Edina, Minnesota, United States, 55435 | |
| United States, Mississippi | |
| Pfizer Investigational Site | |
| Columbus, Mississippi, United States, 39705 | |
| Pfizer Investigational Site | |
| Corinth, Mississippi, United States, 38834 | |
| Pfizer Investigational Site | |
| Tupelo, Mississippi, United States, 38801 | |
| Pfizer Investigational Site | |
| New Albany, Mississippi, United States, 38652 | |
| Pfizer Investigational Site | |
| Oxford, Mississippi, United States, 38655 | |
| Pfizer Investigational Site | |
| Southaven, Mississippi, United States, 38671 | |
| United States, Missouri | |
| Pfizer Investigational Site | |
| Kansas City, Missouri, United States, 64111 | |
| Pfizer Investigational Site | |
| Kansas City, Missouri, United States, 64131 | |
| Pfizer Investigational Site | |
| Kansas City, Missouri, United States, 64154 | |
| Pfizer Investigational Site | |
| Lee's Summit, Missouri, United States, 64064 | |
| United States, Nebraska | |
| Pfizer Investigational Site | |
| Lincoln, Nebraska, United States, 68506 | |
| Pfizer Investigational Site | |
| Omaha, Nebraska, United States, 68105 | |
| Pfizer Investigational Site | |
| Lincoln, Nebraska, United States, 68510 | |
| Pfizer Investigational Site | |
| Lincoln, Nebraska, United States, 68516 | |
| Pfizer Investigational Site | |
| Grand Island, Nebraska, United States, 68803 | |
| Pfizer Investigational Site | |
| Kearney, Nebraska, United States, 68847 | |
| United States, Nevada | |
| Pfizer Investigational Site | |
| Las Vegas, Nevada, United States, 89102 | |
| Pfizer Investigational Site | |
| Las Vegas, Nevada, United States, 89106 | |
| United States, New Hampshire | |
| Pfizer Investigational Site | |
| Lebanon, New Hampshire, United States, 03756-0001 | |
| Pfizer Investigational Site | |
| Manchester, New Hampshire, United States, 03102 | |
| United States, New York | |
| Pfizer Investigational Site | |
| Lake Success, New York, United States, 11042 | |
| Pfizer Investigational Site | |
| Manhasset, New York, United States, 11030 | |
| Pfizer Investigational Site | |
| New Hyde Park, New York, United States, 11040 | |
| Pfizer Investigational Site | |
| Oneida, New York, United States, 13421 | |
| Pfizer Investigational Site | |
| Oswego, New York, United States, 13126 | |
| Pfizer Investigational Site | |
| Syracuse, New York, United States, 13210 | |
| Pfizer Investigational Site | |
| Syracuse, New York, United States, 13210-2306 | |
| United States, North Carolina | |
| Pfizer Investigational Site | |
| Burlington, North Carolina, United States, 27215 | |
| Pfizer Investigational Site | |
| Durham, North Carolina, United States, 27704 | |
| United States, Ohio | |
| Pfizer Investigational Site | |
| Canton, Ohio, United States, 44718 | |
| Pfizer Investigational Site | |
| Dover, Ohio, United States, 44622 | |
| Pfizer Investigational Site | |
| Cleveland, Ohio, United States, 44195 | |
| United States, Oklahoma | |
| Pfizer Investigational Site | |
| Norman, Oklahoma, United States, 73071 | |
| Pfizer Investigational Site | |
| Oklahoma City, Oklahoma, United States, 73102 | |
| Pfizer Investigational Site | |
| Oklahoma City, Oklahoma, United States, 73109 | |
| Pfizer Investigational Site | |
| Oklahoma City, Oklahoma, United States, 73112 | |
| Pfizer Investigational Site | |
| Oklahoma City, Oklahoma, United States, 73120 | |
| Pfizer Investigational Site | |
| Tulsa, Oklahoma, United States, 74104 | |
| Pfizer Investigational Site | |
| Tulsa, Oklahoma, United States, 74133 | |
| Pfizer Investigational Site | |
| Tulsa, Oklahoma, United States, 74136 | |
| United States, Pennsylvania | |
| Pfizer Investigational Site | |
| Allentown, Pennsylvania, United States, 18104 | |
| Pfizer Investigational Site | |
| McKeesport, Pennsylvania, United States, 15132 | |
| Pfizer Investigational Site | |
| Clairton, Pennsylvania, United States, 15025 | |
| Pfizer Investigational Site | |
| Greensburg, Pennsylvania, United States, 15601 | |
| Pfizer Investigational Site | |
| Johnstown, Pennsylvania, United States, 15901 | |
| Pfizer Investigational Site | |
| Bethlehem, Pennsylvania, United States, 18015 | |
| Pfizer Investigational Site | |
| Pittsburgh, Pennsylvania, United States, 15215 | |
| Pfizer Investigational Site | |
| Pittsburgh, Pennsylvania, United States, 15232 | |
| Pfizer Investigational Site | |
| Pittsburgh, Pennsylvania, United States, 15237 | |
| Pfizer Investigational Site | |
| Wexford, Pennsylvania, United States, 15090 | |
| Pfizer Investigational Site | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| Pfizer Investigational Site | |
| Philadelphia, Pennsylvania, United States, 19106 | |
| Pfizer Investigational Site | |
| Radnor, Pennsylvania, United States, 19087 | |
| Pfizer Investigational Site | |
| Sayre, Pennsylvania, United States, 18840 | |
| United States, South Carolina | |
| Pfizer Investigational Site | |
| Columbia, South Carolina, United States, 29203 | |
| Pfizer Investigational Site | |
| Sumter, South Carolina, United States, 29150 | |
| United States, Tennessee | |
| Pfizer Investigational Site | |
| Germantown, Tennessee, United States, 38138 | |
| Pfizer Investigational Site | |
| Bartlett, Tennessee, United States, 38133 | |
| Pfizer Investigational Site | |
| Collierville, Tennessee, United States, 38017 | |
| Pfizer Investigational Site | |
| Memphis, Tennessee, United States, 38119 | |
| Pfizer Investigational Site | |
| Memphis, Tennessee, United States, 38120 | |
| Pfizer Investigational Site | |
| Knoxville, Tennessee, United States, 37909 | |
| Pfizer Investigational Site | |
| Knoxville, Tennessee, United States, 37916 | |
| Pfizer Investigational Site | |
| Knoxville, Tennessee, United States, 37932 | |
| Pfizer Investigational Site | |
| Maryville, Tennessee, United States, 37804 | |
| Pfizer Investigational Site | |
| Knoxville, Tennessee, United States, 37920 | |
| United States, Texas | |
| Pfizer Investigational Site | |
| Grapevine, Texas, United States, 76051 | |
| Pfizer Investigational Site | |
| Irving, Texas, United States, 75063 | |
| Pfizer Investigational Site | |
| Houston, Texas, United States, 77030 | |
| Pfizer Investigational Site | |
| San Antonio, Texas, United States, 78229 | |
| Pfizer Investigational Site | |
| Irving, Texas, United States, 75063 | |
| Pfizer Investigational Site | |
| Southlake, Texas, United States, 76092 | |
| Pfizer Investigational Site | |
| Fort Worth, Texas, United States, 76177 | |
| Pfizer Investigational Site | |
| Fort Worth, Texas, United States, 76177 | |
| Pfizer Investigational Site | |
| Dallas, Texas, United States, 75230-2510 | |
| Pfizer Investigational Site | |
| Austin, Texas, United States, 78731 | |
| Pfizer Investigational Site | |
| Longview, Texas, United States, 75601 | |
| Pfizer Investigational Site | |
| Fort Worth, Texas, United States, 76111 | |
| Pfizer Investigational Site | |
| Sugar Land, Texas, United States, 77479 | |
| Pfizer Investigational Site | |
| Austin, Texas, United States, 78705 | |
| Pfizer Investigational Site | |
| Plano, Texas, United States, 75075-7787 | |
| Pfizer Investigational Site | |
| Austin, Texas, United States, 78745 | |
| Pfizer Investigational Site | |
| Austin, Texas, United States, 78758 | |
| Pfizer Investigational Site | |
| Austin, Texas, United States, 78759-5249 | |
| Pfizer Investigational Site | |
| Round Rock, Texas, United States, 78665 | |
| Pfizer Investigational Site | |
| Round Rock, Texas, United States, 78681 | |
| Pfizer Investigational Site | |
| San Marcos, Texas, United States, 78666 | |
| Pfizer Investigational Site | |
| Tyler, Texas, United States, 75702 | |
| United States, Utah | |
| Pfizer Investigational Site | |
| Bountiful, Utah, United States, 84010 | |
| Pfizer Investigational Site | |
| Layton, Utah, United States, 84041 | |
| Pfizer Investigational Site | |
| Murray, Utah, United States, 84157 | |
| Pfizer Investigational Site | |
| Provo, Utah, United States, 84604 | |
| Pfizer Investigational Site | |
| Salt Lake City, Utah, United States, 84102 | |
| Pfizer Investigational Site | |
| Salt Lake City, Utah, United States, 84106 | |
| Pfizer Investigational Site | |
| West Valley City, Utah, United States, 84120 | |
| United States, Virginia | |
| Pfizer Investigational Site | |
| Gloucester, Virginia, United States, 23061 | |
| Pfizer Investigational Site | |
| Newport News, Virginia, United States, 23601 | |
| Pfizer Investigational Site | |
| Williamsburg, Virginia, United States, 23185 | |
| Pfizer Investigational Site | |
| Woodbridge, Virginia, United States, 22191 | |
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| Fairfax, Virginia, United States, 22031 | |
| Pfizer Investigational Site | |
| Fairfax, Virginia, United States, 22033 | |
| Pfizer Investigational Site | |
| Gainesville, Virginia, United States, 20155 | |
| Pfizer Investigational Site | |
| Leesburg, Virginia, United States, 20176 | |
| Pfizer Investigational Site | |
| Arlington, Virginia, United States, 22205 | |
| Pfizer Investigational Site | |
| Christiansburg, Virginia, United States, 24073 | |
| Pfizer Investigational Site | |
| Roanoke, Virginia, United States, 24014 | |
| Pfizer Investigational Site | |
| Salem, Virginia, United States, 24153 | |
| Pfizer Investigational Site | |
| Wytheville, Virginia, United States, 24382 | |
| United States, Washington | |
| Pfizer Investigational Site | |
| Seattle, Washington, United States, 98104 | |
| Pfizer Investigational Site | |
| Seattle, Washington, United States, 98122 | |
| Pfizer Investigational Site | |
| Seattle, Washington, United States, 98133 | |
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| Spokane, Washington, United States, 99216 | |
| Pfizer Investigational Site | |
| Spokane, Washington, United States, 99218 | |
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| Spokane Valley, Washington, United States, 99202 | |
| Pfizer Investigational Site | |
| Spokane, Washington, United States, 99218 | |
| United States, West Virginia | |
| Pfizer Investigational Site | |
| Wheeling, West Virginia, United States, 26003-6300 | |
| Pfizer Investigational Site | |
| Morgantown, West Virginia, United States, 26506-9162 | |
| Australia, New South Wales | |
| Pfizer Investigational Site | |
| Albury, New South Wales, Australia, 2640 | |
| Pfizer Investigational Site | |
| Port Macquarie, New South Wales, Australia, 2444 | |
| Australia, Victoria | |
| Pfizer Investigational Site | |
| Geelong, Victoria, Australia, 3220 | |
| Pfizer Investigational Site | |
| Wodonga, Victoria, Australia, 3690 | |
| Austria | |
| Pfizer Investigational Site | |
| Linz, Austria, A-4010 | |
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| Innsbruck, Austria, A-6020 | |
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| Wien, Austria, A-1090 | |
| Brazil, RJ | |
| Pfizer Investigational Site | |
| Rio de Janeiro, RJ, Brazil, 20231 -050 | |
| Brazil, RS | |
| Pfizer Investigational Site | |
| Porto Alegre, RS, Brazil, 90035-903 | |
| Brazil, SP | |
| Pfizer Investigational Site | |
| Sao Paulo, SP, Brazil, 01224-010 | |
| Bulgaria | |
| Pfizer Investigational Site | |
| Varna, Bulgaria, 9000 | |
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| Sofia, Bulgaria, 1233 | |
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| Sofia, Bulgaria, 1756 | |
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| Sofia, Bulgaria, 1527 | |
| Canada, Alberta | |
| Pfizer Investigational Site | |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, Ontario | |
| Pfizer Investigational Site | |
| Oshawa, Ontario, Canada, L1G 2B9 | |
| Canada, Quebec | |
| Pfizer Investigational Site | |
| Montreal, Quebec, Canada, H3T 1E2 | |
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| Greenfield Park, Quebec, Canada, J4V 2H1 | |
| Pfizer Investigational Site | |
| Levis, Quebec, Canada, G6V 3Z1 | |
| Czech Republic | |
| Pfizer Investigational Site | |
| Praha 8, Czech Republic, 180 81 | |
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| Pribram V, Czech Republic, 261 95 | |
| Pfizer Investigational Site | |
| Nova Ves Pod Plesi, Czech Republic, 262 04 | |
| Pfizer Investigational Site | |
| Pribram I, Czech Republic, 261 26 | |
| Finland | |
| Pfizer Investigational Site | |
| Helsinki, Finland, 00290 | |
| Pfizer Investigational Site | |
| Pori, Finland, 28500 | |
| France | |
| Pfizer Investigational Site | |
| Lyon Cedex 04, France, 69317 | |
| Pfizer Investigational Site | |
| Saint Herblain Cedex, France, 44805 | |
| Pfizer Investigational Site | |
| Dijon, France, 21079 | |
| Pfizer Investigational Site | |
| Rennes Cedex 9, France, 35033 | |
| Pfizer Investigational Site | |
| Clermond-Ferrand Cedex 01, France, 63003 | |
| Pfizer Investigational Site | |
| Caen Cedex, France, 14033 | |
| Pfizer Investigational Site | |
| Saint Pierre La Réunion Cedex, France, 97448 | |
| Pfizer Investigational Site | |
| Nantes Cedex 2, France, 44202 | |
| Pfizer Investigational Site | |
| Caen Cedex 05, France, 14076 | |
| Germany | |
| Pfizer Investigational Site | |
| Oldenburg, Germany, 26133 | |
| Pfizer Investigational Site | |
| Grosshansdorf, Germany, 22927 | |
| Pfizer Investigational Site | |
| Mainz, Germany, 55131 | |
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| Leipzig, Germany, 04207 | |
| Pfizer Investigational Site | |
| Karlsruhe, Germany, 76137 | |
| Pfizer Investigational Site | |
| Berlin, Germany, 14165 | |
| Pfizer Investigational Site | |
| Gauting, Germany, 82131 | |
| Greece | |
| Pfizer Investigational Site | |
| Athens, Greece, 11527 | |
| Pfizer Investigational Site | |
| Thessaloniki, Greece, 56429 | |
| Pfizer Investigational Site | |
| Athens, Greece, 10676 | |
| Greece, Pylaia | |
| Pfizer Investigational Site | |
| Thessaloniki, Pylaia, Greece, 57001 | |
| Hong Kong | |
| Pfizer Investigational Site | |
| Shatin, New Territories, Hong Kong | |
| Pfizer Investigational Site | |
| Kowloon, Hong Kong, 0 | |
| Pfizer Investigational Site | |
| Tuen Mun, Hong Kong | |
| Hungary | |
| Pfizer Investigational Site | |
| Szombathely, Hungary, 9700 | |
| Pfizer Investigational Site | |
| Torokbalint, Hungary, 2045 | |
| Pfizer Investigational Site | |
| Szekesfehervar, Hungary, 8000 | |
| Pfizer Investigational Site | |
| Deszk, Hungary, 6772 | |
| Pfizer Investigational Site | |
| Budapest, Hungary, 1525 | |
| India | |
| Pfizer Investigational Site | |
| New Delhi, India, 110 030 | |
| India, GUJARAT | |
| Pfizer Investigational Site | |
| Navrangpura / Ahmedabad, GUJARAT, India, 380 009 | |
| India, Karnataka | |
| Pfizer Investigational Site | |
| Bangalore, Karnataka, India, 560 078 | |
| India, Maharashtra | |
| Pfizer Investigational Site | |
| Mumbai, Maharashtra, India, 400 012 | |
| Pfizer Investigational Site | |
| Nagpur, Maharashtra, India, 440012 | |
| Ireland | |
| Pfizer Investigational Site | |
| Dublin, Ireland, 9 | |
| Pfizer Investigational Site | |
| Dublin 24, Ireland | |
| Italy | |
| Pfizer Investigational Site | |
| Orbassano (to), Italy, 10043 | |
| Pfizer Investigational Site | |
| Genova, Italy, 16132 | |
| Pfizer Investigational Site | |
| Padova, Italy, 35128 | |
| Pfizer Investigational Site | |
| Roma, Italy, 00152 | |
| Japan | |
| Pfizer Investigational Site | |
| Koto-ku, Tokyo, Japan | |
| Pfizer Investigational Site | |
| Fukuoka, Japan | |
| Pfizer Investigational Site | |
| Osaka, Japan | |
| Japan, Aichi | |
| Pfizer Investigational Site | |
| Nagoya, Aichi, Japan | |
| Pfizer Investigational Site | |
| Okazaki-City, Aichi, Japan | |
| Japan, Chiba | |
| Pfizer Investigational Site | |
| Kashiwa, Chiba, Japan | |
| Japan, Ehime | |
| Pfizer Investigational Site | |
| Matsuyama-shi, Ehime, Japan | |
| Japan, Gifu | |
| Pfizer Investigational Site | |
| Gifu-shi, Gifu, Japan | |
| Japan, Hokkaido | |
| Pfizer Investigational Site | |
| Sapporo-shi, Hokkaido, Japan | |
| Pfizer Investigational Site | |
| Sapporo-shi, Hokkaido, Japan | |
| Japan, Hyogo | |
| Pfizer Investigational Site | |
| Akashi, Hyogo, Japan | |
| Japan, Kanagawa | |
| Pfizer Investigational Site | |
| Yokohama-city, Kanagawa, Japan | |
| Pfizer Investigational Site | |
| Yokohama, Kanagawa, Japan | |
| Japan, Niigata | |
| Pfizer Investigational Site | |
| Niigata-shi, Niigata, Japan | |
| Japan, Okayama | |
| Pfizer Investigational Site | |
| Okayama-city, Okayama, Japan | |
| Japan, Osaka | |
| Pfizer Investigational Site | |
| Habikino-shi, Osaka, Japan | |
| Pfizer Investigational Site | |
| Osakasayama-shi, Osaka, Japan | |
| Pfizer Investigational Site | |
| Osaka-city, Osaka, Japan | |
| Pfizer Investigational Site | |
| Osaka-city, Osaka, Japan | |
| Japan, Osaka-fu | |
| Pfizer Investigational Site | |
| Sakai-shi, Osaka-fu, Japan | |
| Japan, Shizuoka | |
| Pfizer Investigational Site | |
| Sunto-gun, Shizuoka, Japan | |
| Japan, Tokyo | |
| Pfizer Investigational Site | |
| Chuo-Ku, Tokyo, Japan | |
| Japan, Yamaguchi | |
| Pfizer Investigational Site | |
| Ube-shi, Yamaguchi, Japan | |
| Korea, Republic of | |
| Pfizer Investigational Site | |
| Seoul, Korea, Republic of, 110-744 | |
| Pfizer Investigational Site | |
| Seoul, Korea, Republic of, 135-710 | |
| Pfizer Investigational Site | |
| Gyeonggi-do, Korea, Republic of, 410-769 | |
| Pfizer Investigational Site | |
| Seoul, Korea, Republic of, 138-736 | |
| Poland | |
| Pfizer Investigational Site | |
| Warszawa, Poland, 02-781 | |
| Pfizer Investigational Site | |
| Warszawa, Poland, 01-138 | |
| Pfizer Investigational Site | |
| Krakow, Poland, 31-115 | |
| Pfizer Investigational Site | |
| Siedlce, Poland, 08-110 | |
| Pfizer Investigational Site | |
| Warszawa, Poland, 02-097 | |
| Pfizer Investigational Site | |
| Wroclaw, Poland, 53-439 | |
| Pfizer Investigational Site | |
| Gdansk, Poland, 80-952 | |
| Puerto Rico | |
| Pfizer Investigational Site | |
| Ponce, Puerto Rico, 00716 | |
| Pfizer Investigational Site | |
| Manatí, Puerto Rico, 00674 | |
| Pfizer Investigational Site | |
| San Juan, Puerto Rico, 00917 | |
| Pfizer Investigational Site | |
| San Juan, Puerto Rico, 00935 | |
| Russian Federation | |
| Pfizer Investigational Site | |
| St-Petersburg, Russian Federation, 194044 | |
| Pfizer Investigational Site | |
| St. Petersburg, Russian Federation, 198255 | |
| Pfizer Investigational Site | |
| Sochi, Russian Federation, 354057 | |
| Pfizer Investigational Site | |
| Moscow, Russian Federation, 115478 | |
| Pfizer Investigational Site | |
| Moscow, Russian Federation, 111033 | |
| Pfizer Investigational Site | |
| Saint-Petersburg, Russian Federation, 197089 | |
| Pfizer Investigational Site | |
| Samara, Russian Federation, 443066 | |
| Slovakia | |
| Pfizer Investigational Site | |
| Nitra-Zobor, Slovakia, 949 88 | |
| Pfizer Investigational Site | |
| Nove Zamky, Slovakia, 94034 | |
| Pfizer Investigational Site | |
| Kosice, Slovakia, 041 90 | |
| Pfizer Investigational Site | |
| Poprad, Slovakia, 058 01 | |
| Spain | |
| Pfizer Investigational Site | |
| Cordoba, Spain, 14004 | |
| Pfizer Investigational Site | |
| Madrid, Spain, 28033 | |
| Pfizer Investigational Site | |
| Valencia, Spain, 46010 | |
| Spain, BARCELONA | |
| Pfizer Investigational Site | |
| L'hospitalet de Llobregat, BARCELONA, Spain, 08907 | |
| Spain, CANTABRIA | |
| Pfizer Investigational Site | |
| Santander, CANTABRIA, Spain, 39008 | |
| Spain, NAVARRA | |
| Pfizer Investigational Site | |
| Pamplona, NAVARRA, Spain, 31008 | |
| Switzerland | |
| Pfizer Investigational Site | |
| Zuerich, Switzerland, 8091 | |
| Pfizer Investigational Site | |
| Fribourg, Switzerland, 1708 | |
| Taiwan | |
| Pfizer Investigational Site | |
| Taipei, Taiwan, 112 | |
| Pfizer Investigational Site | |
| Taichung, Taiwan, 40705 | |
| Pfizer Investigational Site | |
| Tainan, Taiwan, 704 | |
| Pfizer Investigational Site | |
| Taipei, Taiwan, 100 | |
| Pfizer Investigational Site | |
| Taipei, Taiwan, 114 | |
| Taiwan, Kaohsiung Hsien | |
| Pfizer Investigational Site | |
| Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, 833 | |
| Turkey | |
| Pfizer Investigational Site | |
| Ankara, Turkey, 06100 | |
| Pfizer Investigational Site | |
| Adana, Turkey, 01330 | |
| Pfizer Investigational Site | |
| Ankara, Turkey, 06500 | |
| Turkey, Ankara | |
| Pfizer Investigational Site | |
| Sihhiye, Ankara, Turkey, 06100 | |
| Ukraine | |
| Pfizer Investigational Site | |
| Sumy, Ukraine, 40005 | |
| Pfizer Investigational Site | |
| Kyiv, Ukraine, 03115 | |
| Pfizer Investigational Site | |
| Dnipropetrovsk, Ukraine, 49102 | |
| Pfizer Investigational Site | |
| Donetsk, Ukraine, 83092 | |
| Pfizer Investigational Site | |
| Lviv, Ukraine, 79031 | |
| Study Director: | Pfizer CT.gov Call Center | Pfizer |
More Information
| Responsible Party: | Pfizer, Inc. ( Director, Clinical Trial Disclosure Group ) |
| Study ID Numbers: | A4021016 |
| Study First Received: | January 3, 2008 |
| Last Updated: | November 11, 2009 |
| ClinicalTrials.gov Identifier: | NCT00596830 History of Changes |
| Health Authority: | United States: Food and Drug Administration |
|
IGF-1R inhibitor Non-small-cell lung carcinoma CP-751871 |
|
Thoracic Neoplasms Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Neoplasms by Site Respiratory Tract Diseases Lung Neoplasms Therapeutic Uses Neoplasms, Squamous Cell Respiratory Tract Neoplasms Neoplasms by Histologic Type Mitosis Modulators Carboplatin Antimitotic Agents |
Pharmacologic Actions Carcinoma Neoplasms Paclitaxel Lung Diseases Carcinoma, Large Cell Tubulin Modulators Carcinoma, Squamous Cell Antineoplastic Agents, Phytogenic Carcinoma, Adenosquamous Carcinoma, Non-Small-Cell Lung Neoplasms, Complex and Mixed Neoplasms, Glandular and Epithelial |
