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| Sponsor: | The University of Texas Health Science Center at San Antonio |
|---|---|
| Information provided by: | The University of Texas Health Science Center at San Antonio |
| ClinicalTrials.gov Identifier: | NCT00595595 |
Purpose
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.
| Condition |
|---|
|
Regenerative Endodontic Tissue Engineering Dental Pulp Diseases |
| Study Type: | Observational |
| Study Design: | Case Control, Cross-Sectional |
| Official Title: | Development of a Model to Evaluate Regenerative Endodontic Techniques |
extracted teeth 10ml of blood for DNA banking
| Estimated Enrollment: | 1080 |
| Study Start Date: | February 2007 |
| Estimated Study Completion Date: | February 2010 |
| Estimated Primary Completion Date: | February 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| 1 |
| 2 |
The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.
Eligibility| Ages Eligible for Study: | 16 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Patients presenting for surgical removal of impacted teeth
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Texas | |
| The University of Texas Health Science Center at San Antonio | Recruiting |
| San Antonio, Texas, United States, 78229 | |
| Contact: Kenneth M. Hargreaves, DDS, PhD 210-567-3385 Hargreaves@uthscsa.edu | |
| Contact: Erin Locke, RN, BSN 210-567-0895 Locke@uthscsa.edu | |
| Principal Investigator: Kenneth M. Hargreaves, DDS, PhD | |
| Sub-Investigator: Karl Keiser, DDS, MS | |
| Principal Investigator: | Kenneth M Hargreaves, DDS, PhD | University of Texas |
More Information
| Responsible Party: | University of Texas Health Science Center at San Antonio ( Kenneth M. Hargreaves ) |
| Study ID Numbers: | HSC20070149H |
| Study First Received: | January 7, 2008 |
| Last Updated: | March 13, 2009 |
| ClinicalTrials.gov Identifier: | NCT00595595 History of Changes |
| Health Authority: | United States: Institutional Review Board |
|
Dental Pulp Regenerative Medicine Odontoblasts |
Stem Cells Growth factor differentiation of stem/progenitor cells Odontoblast-specific cell phenotypes |
|
Tooth Diseases Dental Pulp Diseases Stomatognathic Diseases |
