Inclusion Criteria:

• Thoracic aortic disease deemed to warrant exclusion in order to prevent rupture or extension including dissection and transections.
• Anatomy meets Thoracic EXCLUDER Endoprosthesis specification criteria.

• Minimum 2 cm non-aneurysmal segment proximal and distal to the aneurysm.

  • < 60 angle in the aortic arch may require additional length of non- aneurysmal segment if the arch is included in the treatment segment.
• The patient is of a "high risk" status for surgical repair. The patient is characterized by the presence of co-morbid factors and/or thoracic aortic pathology that place the patient in a category of prohibitive risk for open repair, and, without intervention, and adverse event could be anticipated within days or weeks. The patient has an ASA score of IV or V.
• Ability to comply with protocol requirements including follow-up.
• Signed Informed Consent Form.

Exclusion Criteria:

• > 4 mm aortic taper and inability to use devices of different diameters, to compensate for the taper, in the treatment area of the aorta.
• Significant thrombus at the proximal or distal implantation sites.
• Planned occlusion of the left carotid or celiac arteries, unless supplemental conduit provided.
• Myocardial infarction within six weeks.
• Degenerative connective tissue disease, e.g. Marfan's or Ehler Danlos Syndrome, unless the proximal and distal implantation sites of the Thoracic EXCLUDER Endoprosthesis are located within previously placed surgical grafts.
• Female of child bearing potential with positive pregnancy test.