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Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula

This study has been completed.
Sponsor:
Information provided by:
Centre Hospitalier Universitaire de Saint Etienne
ClinicalTrials.gov Identifier:
NCT00542906
First received: October 11, 2007
Last updated: June 16, 2009
Last verified: June 2009
History of Changes
  Purpose

The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown.

The aim of this fMRI study is to determine the functional cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volunteers, will be compared.


Condition Intervention
Healthy
 Other: localization

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area (SII) and Insula : an fMRI Study

Resource links provided by NLM:

MedlinePlus related topics: Anatomy
U.S. FDA Resources

Further study details as provided by Centre Hospitalier Universitaire de Saint Etienne:

Primary Outcome Measures:
  • Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula. [ Time Frame: one day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Determine the Talairach coordinates of the centroids of clusters of activations for the different types of somatosensory stimuli into SII and insula [ Time Frame: one day ] [ Designated as safety issue: No ]

Enrollment: 25
Study Start Date: October 2007
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
1
healthy volunteers
 Other: localization
localization of the several types of somatosensory stimuli

Detailed Description:

Aims : Demonstrate that localization of the several types of somatosensory stimuli is different into SII and into insula. If possible, we'll determine a functional cartography of these areas.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 25 healthy volunteers will be included ranging in age from 18 to 50 years
  • contraception needed for women
  • right handed
  • All the subjects have to give their written informed consent.

Exclusion Criteria:

  • pregnancy
  • neurological or psychiatric disease
  • drugs taken <12h before fMRI
  • contra-indications to fMRI : pacemaker, clip, metallic device
  • Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00542906

Locations
France
Service de Neurologie - CHU de Saint-Etienne
Saint-Etienne, France, 42055
Sponsors and Collaborators
Centre Hospitalier Universitaire de Saint Etienne
Investigators
Principal Investigator: Laure Mazzola, MD CHU de Saint-Etienne
  More Information

Publications:

Responsible Party: Clément CAILLAUX, Centre Hospitalier Universitaire de Saint Etienne
ClinicalTrials.gov Identifier: NCT00542906     History of Changes
Other Study ID Numbers: 0701023, 2007-A00328-45, DGS 2007-0273
Study First Received: October 11, 2007
Last Updated: June 16, 2009
Health Authority: France: Direction Générale de la Santé

Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:
healthy volunteers
Somatosensory stimuli
fMRI
 second somatosensory area
insular cortex
functional anatomy

ClinicalTrials.gov processed this record on June 17, 2013