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| Sponsor: | Ariad Pharmaceuticals |
|---|---|
| Collaborator: |
Merck |
| Information provided by: | Ariad Pharmaceuticals |
| ClinicalTrials.gov Identifier: | NCT00538239 |
Purpose
The purpose of this study is to determine whether maintenance therapy with oral AP23573 (ridaforolimus), by preventing and controlling tumor growth for a prolonged period of time in patients with metastatic soft-tissue or bone sarcomas responding to chemotherapy, will result in clinically significant improvement in progression-free survival as compared to oral placebo.
| Condition | Intervention | Phase |
|---|---|---|
|
Metastatic Soft-Tissue Sarcomas Metastatic Bone Sarcomas |
Drug: ridaforolimus Drug: Placebo |
Phase III |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment |
| Official Title: | A Pivotal Trial to Determine the Efficacy and Safety of AP23573 When Administered as Maintenance Therapy to Patients With Metastatic Soft-Tissue or Bone Sarcomas |
| Estimated Enrollment: | 650 |
| Study Start Date: | September 2007 |
| Estimated Study Completion Date: | June 2014 |
| Estimated Primary Completion Date: | June 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Ridaforolimus: Experimental |
Drug: ridaforolimus
40 mg, Oral, QDx5 (five consecutive days each week followed by two day holiday) until disease progression
|
| Placebo: Placebo Comparator |
Drug: Placebo
Placebo
|
Eligibility| Ages Eligible for Study: | 13 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Toll-Free Phone Number (US callers only) | 877-621-2302 | |
| Contact: International callers | 1-617-621-2302 |
Hide Study Locations| United States, Alaska | |
| ARIAD Investigational Site #102 | Withdrawn |
| Anchorage, Alaska, United States, 99508 | |
| United States, Arizona | |
| ARIAD Investigational Site #046 | Recruiting |
| Tucson, Arizona, United States, 85724 | |
| United States, California | |
| ARIAD Investigational Site # 014 | Recruiting |
| Santa Monica, California, United States, 90403 | |
| ARIAD Investigational Site # 053 | Recruiting |
| Burbank, California, United States, 91505 | |
| ARIAD Investigational Site # 009 | Recruiting |
| Duarte, California, United States, 91010 | |
| ARIAD Investigational Site #093 | Recruiting |
| Orange, California, United States, 92868 | |
| ARIAD Investigational Site #010 | Recruiting |
| Los Angeles, California, United States, 90033 | |
| ARIAD Investigational Site #119 | Recruiting |
| Monterey, California, United States, 93940 | |
| ARIAD Investigational Site #099 | Recruiting |
| La Jolla, California, United States, 92103 | |
| ARIAD Investigational Site #020 | Recruiting |
| Los Angeles, California, United States, 90048 | |
| ARIAD Investigational Site # 071 | Recruiting |
| Sacramento, California, United States, 95817 | |
| United States, Colorado | |
| ARIAD Investigational Site #015 | Recruiting |
| Aurora, Colorado, United States, 80045 | |
| United States, Florida | |
| ARIAD Investigational Site # 052 | Recruiting |
| Ft. Lauderdale, Florida, United States, 33308 | |
| ARIAD Investigational Site #017 | Recruiting |
| Tampa, Florida, United States, 33612 | |
| ARIAD Investigational Site #096 | Recruiting |
| Miami, Florida, United States, 33136 | |
| United States, Georgia | |
| ARIAD Investigational Site #058 | Recruiting |
| Atlanta, Georgia, United States, 30308 | |
| United States, Idaho | |
| ARIAD Investigational Site #049 | Recruiting |
| Coeur D'Alene, Idaho, United States, 83814 | |
| United States, Illinois | |
| ARIAD Investigational Site # 001 | Recruiting |
| Chicago, Illinois, United States, 60637 | |
| ARIAD Investigational Site # 055 | Withdrawn |
| Park Ridge, Illinois, United States, 60068 | |
| ARIAD Investigational Site # 054 | Recruiting |
| Maywood, Illinois, United States, 60153 | |
| ARIAD Investigational Site #023 | Recruiting |
| Chicago, Illinois, United States, 60611 | |
| United States, Indiana | |
| ARIAD Investigational Site # 037 | Recruiting |
| Indianapolis, Indiana, United States, 46202 | |
| United States, Iowa | |
| ARIAD Investigational Site # 050 | Recruiting |
| Iowa City, Iowa, United States, 52242 | |
| United States, Kansas | |
| ARIAD Investigational Site # 062 | Recruiting |
| Overland Park, Kansas, United States, 66209 | |
| United States, Maryland | |
| ARIAD Investigational Site #040 | Withdrawn |
| Baltimore, Maryland, United States, 21201 | |
| ARIAD Investigational Site #059 | Recruiting |
| Baltimore, Maryland, United States, 21231 | |
| United States, Massachusetts | |
| ARIAD Investigational Site # 008 | Recruiting |
| Boston, Massachusetts, United States, 02115 | |
| ARIAD Investigational Site #047 | Recruiting |
| Boston, Massachusetts, United States, 02114 | |
| United States, Minnesota | |
| ARIAD Investigational Site #044 | Recruiting |
| Rochester, Minnesota, United States, 55905 | |
| ARIAD Investigational Site #101 | Recruiting |
| Minneapolis, Minnesota, United States, 55455 | |
| United States, Missouri | |
| ARIAD Investigational Site # 051 | Withdrawn |
| Jefferson City, Missouri, United States, 65109 | |
| ARIAD Investigational Site #007 | Recruiting |
| St. Louis, Missouri, United States, 63110 | |
| United States, Montana | |
| ARIAD Investigational Site #105 | Withdrawn |
| Billings, Montana, United States, 59101 | |
| United States, Nebraska | |
| ARIAD Investigational Site #074 | Withdrawn |
| Omaha, Nebraska, United States, 68198 | |
| United States, New Mexico | |
| ARIAD Investigational Site # 060 | Recruiting |
| Albuquerque, New Mexico, United States, 87131-0001 | |
| United States, New York | |
| ARIAD Investigational Site #065 | Recruiting |
| Stony Brook, New York, United States, 11794 | |
| ARIAD Investigational Site #029 | Withdrawn |
| Buffalo, New York, United States, 14263 | |
| ARIAD Investigational Site #072 | Recruiting |
| New York, New York, United States, 10032 | |
| ARIAD Investigational Site #094 | Recruiting |
| Syracuse, New York, United States, 13210 | |
| ARIAD Investigational Site # 092 | Recruiting |
| New York, New York, United States, 10011 | |
| ARIAD Investigational Site # 117 | Recruiting |
| Rochester, New York, United States, 14642 | |
| ARIAD Investigational Site # 124 | Recruiting |
| New York, New York, United States, 10032 | |
| United States, North Carolina | |
| ARIAD Investigational Site #003 | Recruiting |
| Durham, North Carolina, United States, 27710 | |
| ARIAD Investigational Site #056 | Withdrawn |
| Charlotte, North Carolina, United States, 28203 | |
| United States, Ohio | |
| ARIAD Investigational Site # 022 | Withdrawn |
| Canton, Ohio, United States, 44718 | |
| United States, Pennsylvania | |
| ARIAD Investigational Site # 021 | Recruiting |
| Philadelphia, Pennsylvania, United States, 19106 | |
| ARIAD Investigational Site #012 | Recruiting |
| Philadelphia, Pennsylvania, United States, 19111 | |
| ARIAD Investigational Site #066 | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15232 | |
| United States, South Carolina | |
| ARIAD Investigational Site #064 | Withdrawn |
| Charleston, South Carolina, United States, 29425 | |
| ARIAD Investigational Site #090 | Withdrawn |
| Columbia, South Carolina, United States, 29210 | |
| United States, Tennessee | |
| ARIAD Investigational Site #097 | Recruiting |
| Nashville, Tennessee, United States, 37232 | |
| United States, Texas | |
| ARIAD Investigational Site #039 | Recruiting |
| San Antonio, Texas, United States, 75246 | |
| ARIAD Investigational Site #019 | Recruiting |
| Dallas, Texas, United States, 75246 | |
| ARIAD Investigational Site #002 | Recruiting |
| San Antonio, Texas, United States, 78229 | |
| ARIAD Investigational Site #063 | Recruiting |
| Houston, Texas, United States, 77030 | |
| ARIAD Investigational Site #106 | Withdrawn |
| Dallas, Texas, United States, 75231 | |
| ARIAD Investigational Site #107 | Withdrawn |
| Tyler, Texas, United States, 75702 | |
| ARIAD Investigational Site #790 | Recruiting |
| Houston, Texas, United States, 77030 | |
| United States, Utah | |
| ARIAD Investigational Site # 045 | Recruiting |
| Salt Lake City, Utah, United States, 84106 | |
| ARIAD Investigational Site # 043 | Recruiting |
| Salt Lake City, Utah, United States, 84112 | |
| United States, Vermont | |
| ARIAD Investigational Site #089 | Recruiting |
| Burlington, Vermont, United States, 05401 | |
| United States, Virginia | |
| ARIAD Investigational Site #042 | Recruiting |
| Fairfax, Virginia, United States, 22031 | |
| United States, Washington | |
| ARIAD Investigational Site #100 | Recruiting |
| Seattle, Washington, United States, 98109 | |
| Australia, Australian Capital Territory | |
| ARIAD Investigational Site #911, The Canberra Hospital | Recruiting |
| Garran, Australian Capital Territory, Australia, 2606 | |
| Australia, New South Wales | |
| ARIAD Investigational Site #900, Prince of Wales Hospital | Recruiting |
| Randwick, New South Wales, Australia, 2031 | |
| ARIAD Investigational Site #901, Sydney Cancer Center | Recruiting |
| Camperdown, New South Wales, Australia, 2050 | |
| Australia, South Australia | |
| ARIAD Investigational Site #912, Ashford Cancer Centre | Withdrawn |
| Ashford, South Australia, Australia, 5035 | |
| Australia, Victoria | |
| ARIAD Investigational Site #920, Children's Cancer Center, Royal Children's Hospital | Withdrawn |
| Parkville, Victoria, Australia, 3052 | |
| Australia, Western Australia | |
| ARIAD Investigational Site #919, Mount Medical Centre | Recruiting |
| Perth, Western Australia, Australia, 6000 | |
| Brazil | |
| ARIAD Investigational Site #806, Centro de Oncologia Inrad - HCFMUSP | Recruiting |
| Sao Paulo, Brazil, 01246 | |
| Brazil, Rio Grande do Sol | |
| ARIAD Investigational Site #805, Clinica de Oncologia de Porto Alegre | Recruiting |
| Porto Alegre, Rio Grande do Sol, Brazil, 90430-090 | |
| Brazil, Sao Paulo | |
| ARIAD Investigational Site #820, Fundacao Pio XII - Hospital de Cancer De Barretos | Recruiting |
| Barretos, Sao Paulo, Brazil, 14784-400 | |
| Brazil, SP | |
| ARIAD Investigational Site # 804, Fundacao Antonio Prudente Hospital A.C. Camargo | Recruiting |
| Sao Paulo, SP, Brazil, 01509-900 | |
| Canada, Alberta | |
| ARIAD Investigational Site #086, Cross Cancer Institute | Withdrawn |
| Edmonton, Alberta, Canada, T6G1Z2 | |
| Canada, Manitoba | |
| ARIAD Investigational Site #087, CancerCare Manitoba | Recruiting |
| Winnipeg, Manitoba, Canada, R2H2A6 | |
| Canada, Nova Scotia | |
| ARIAD Investigational Site #081, QEII Health Sciences Centre | Withdrawn |
| Halifax, Nova Scotia, Canada, NS B3H 1V7 | |
| Canada, Ontario | |
| ARIAD Investigational Site #088, London Regional Cancer Program | Recruiting |
| London, Ontario, Canada, N6A 4L6 | |
| ARIAD Investigational Site # 083, Princess Margaret Hospital | Recruiting |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Canada, Quebec | |
| ARIAD Investigational Site #079, Royal Victoria Hospital | Recruiting |
| Montreal, Quebec, Canada, H2W 1S6 | |
| Chile | |
| ARIAD Investigational Site #808, Oncomed (Dr. Francisco Javier Orlandi Jorquera) | Recruiting |
| Santiago, Chile, 7510032 | |
| ARIAD Investigational Site #807, Instituto Nacional del Cancer (Dr. Berta Silvia Cerda Alvarez) | Recruiting |
| Santiago, Chile, 8380-455 | |
| China | |
| ARIAD Investigational Site #930, Tianjin Cancer Hospital | Recruiting |
| Tianjin, China, 300060 | |
| Colombia, Narino | |
| ARIAD Investigational Site #821, Unidad de Oncologia Clinica los Andes (Dr. Carlos J. Narvaez L.) | Withdrawn |
| Pasto, Narino, Colombia, 704 | |
| Czech Republic, Central Bohemian Region | |
| ARIAD Investigational Site #718, University Hospital Motol | Recruiting |
| Prague, Central Bohemian Region, Czech Republic, 150 06 | |
| Czech Republic, Moravia | |
| ARIAD Investigational Site #717, Masaryk Memorial Cancer Institute | Recruiting |
| Brno, Moravia, Czech Republic, 65653 | |
| France | |
| ARIAD Investigational Site # 789, Institut Paoli Calmette - Marseille | Recruiting |
| Marseille, France, 13273 | |
| ARIAD Investigational Site # 500, Hospital Jean Minjoz | Recruiting |
| Besancon Dedex, France, 25030 | |
| ARIAD Investigational Site #791, Institut Claudius Regaud | Recruiting |
| Toulouse Cedex, France, 31052 | |
| France, Cedex | |
| ARIAD Investigational Site # 772, Institut Bergonie | Recruiting |
| Bordeaux, Cedex, France, 33076 | |
| ARIAD Investigational Site # 788, Centre Regional de Lutte contre le Cancer Val D'Aurelle | Recruiting |
| Montpellier, Cedex, France, 34298 | |
| France, Cedx 05 | |
| ARIAD Investigational Site #781, Institut Curie | Recruiting |
| Paris, Cedx 05, France, 75248 | |
| France, Cote-d'Or | |
| ARIAD Investigational Site #750, Centre Georges-Francois Leclerc | Recruiting |
| Dijon, Cote-d'Or, France, 21079 | |
| France, Ile-de-France | |
| ARIAD Investigational Site #703, Institut Gustave Roussy | Recruiting |
| Villejuif, Ile-de-France, France, 94805 | |
| France, Nord-Pas de Calais | |
| ARIAD Investigational Site #736, Centre Oscar Lambert - Lille | Recruiting |
| Lille, Nord-Pas de Calais, France, 5900 | |
| France, Pays de la Loire | |
| ARIAD Investigational Site #751, Centre Rene Gauducheau-Saint Herblain | Recruiting |
| Nantes, Pays de la Loire, France, 44805 | |
| France, Provence-Alpes-Cote d'Azure | |
| ARIAD Investigational Site #739, Centre Hospitalo-Universitaire Timone Adultes-Marseille | Recruiting |
| Marseille, Provence-Alpes-Cote d'Azure, France, 13385 | |
| France, Rhone-Alpes | |
| ARIAD Investigational Site #702, Hospital Edouard Herriot-Lyon | Recruiting |
| Lyon, Rhone-Alpes, France, 69003 | |
| ARIAD Investigational Site #746, Centre Leon Berard | Recruiting |
| Lyon, Rhone-Alpes, France, 69373 | |
| Germany | |
| ARIAD Investigational Site # 794, Klinik fur Hamatologie Hamostaseologie | Recruiting |
| Hannover, Germany, 30625 | |
| Germany, Bradenburg | |
| ARIAD Investigational Site #729, Helios Klinikum Bad Saarow | Recruiting |
| Bad Saarow, Bradenburg, Germany, 15526 | |
| Germany, Hesse | |
| ARIAD Investigational Site #741 | Recruiting |
| Frankfurt, Hesse, Germany, 60590 | |
| Germany, Saxony | |
| ARIAD Investigational Site #728, Klinik fur Gynakologie und Geburtshilfe | Recruiting |
| Aue, Saxony, Germany, 08280 | |
| Greece | |
| ARIAD Investigational Site # 727, Anti-Cancer Hospital of Thessaloniki "Theagenio" | Recruiting |
| Thessaloniki, Greece, 54007 | |
| Greece, Crete | |
| ARIAD Investigational Site # 742, University Hospital of Iraklion | Recruiting |
| Iraklion, Crete, Greece, 71110 | |
| India | |
| ARIAD Investigational Site #924, Kidwai Memorial Institute of Oncology | Recruiting |
| Bangalore, India, 560029 | |
| India, Andhra Pradesh | |
| ARIAD Investigational Site #908, Nizam's Institute of Medical Sciences | Withdrawn |
| Hyderabaad, Andhra Pradesh, India, 500082 | |
| ARIAD Investigational Site #906, Krishna Institute of Medical Sciences (KIMS) (Dr. Anjna Surath) | Withdrawn |
| Secunderabad, Andhra Pradesh, India, 500 033 | |
| India, Gujarat | |
| ARIAD Investigational Site #902, Vedanta Instiute of Medical Sciences (Dr. Chirag Desai) | Recruiting |
| Ahmedabad, Gujarat, India, 380009 | |
| India, Kerala | |
| ARIAD Investigational Site #904, Regional Cancer Centre (Dr. Sreejith Gopinathan Nair) | Recruiting |
| Thiruvananthapuram, Kerala, India, 69501 | |
| India, Maharashta | |
| ARIAD Investigational Site #910, Tata Memorial Hospital (Dr. Sudeep Gupta) | Recruiting |
| Mumbai, Maharashta, India, 400012 | |
| India, Maharashtra | |
| ARIAD Investigational Site #905, Jehangir Clinical Development Centre Pvt. Ltd. | Recruiting |
| Pune, Maharashtra, India, 411 011 | |
| India, Rajasthan | |
| ARIAD Investigational Site #909, Searoc Cancer Center (Dr. Anish Maru) | Recruiting |
| Jaipur, Rajasthan, India, 302013 | |
| India, Tamil Nadu | |
| ARIAD Investigational Site #903, Apollo Specialty Hospital (Dr. Ranjan Kumar Mohapatra) | Recruiting |
| Chennai, Tamil Nadu, India, 600035 | |
| ARIAD Investigational Site #907, Christian Medical College (Dr. Subhashini John) | Recruiting |
| Vellore, Tamil Nadu, India, 632 004 | |
| Israel | |
| ARIAD Investigational Site #761, Rambam Medical Center | Recruiting |
| Haifa, Israel, 35254 | |
| ARIAD Investigational Site #716, Hadassah University Hospital | Recruiting |
| Jerusalem, Israel, 91120 | |
| Israel, Gush Dan | |
| ARIAD Investigational Site #732, Tel Aviv Sourasky Medical Center | Recruiting |
| Tel Aviv, Gush Dan, Israel, 64239 | |
| Israel, Tel Aviv district | |
| ARIAD Investigational Site #731, The Chaim Medical Center | Recruiting |
| Ramat Gan, Tel Aviv district, Israel, 52621 | |
| Italy | |
| ARIAD Investigational Site #767, University Campus Bio-Medico of Rome | Recruiting |
| Rome, Italy, 00128 | |
| Italy, Emilia Romagna | |
| ARIAD Investigational Site #726, Istituto Ortopedica Rizzoli | Recruiting |
| Bologna, Emilia Romagna, Italy, 40136 | |
| Italy, Lazio | |
| ARIAD Investigational Site #768, Istituto Regina Elena | Recruiting |
| Rome, Lazio, Italy, 00144 | |
| Italy, Lombardy | |
| ARIAD Investigational Site #705, IRCCS Instituto Nazionale Dei Tumori | Recruiting |
| Milan, Lombardy, Italy, 20133 | |
| Italy, Province of Milan | |
| ARIAD Investigational Site #740, Instituto Clinico Humanitas | Recruiting |
| Rozzano, Province of Milan, Italy, 20089 | |
| Italy, Province of Turino | |
| ARIAD Investigational Site #737, Instituto per la Ricerca e la Cura del Cancro (IRCC) | Recruiting |
| Candiolo, Province of Turino, Italy, 1-10060 | |
| Italy, Sicily | |
| ARIAD Investigational Site #760, University of Palermo | Recruiting |
| Palermo, Sicily, Italy, 90127 | |
| Italy, Veneto | |
| ARIAD Investigational Site #733, Instituto Oncologico Vento IOV IRCCS | Recruiting |
| Padua, Veneto, Italy, 35128 | |
| Korea, Republic of | |
| ARIAD Investigational Site #918, Samsung Medical Center | Recruiting |
| Seoul, Korea, Republic of, 135-710 | |
| ARIAD Investigational Site #915, Seoul National University Hospital | Recruiting |
| Seoul, Korea, Republic of, 110-744 | |
| ARIAD Investigational Site #916, National Cancer Center (Dr. Tak Yun) | Recruiting |
| Seoul, Korea, Republic of, 410-769 | |
| ARIAD Investigational Site #917, Asan Medical Center (Dr. Jin-Hee Ahn) | Recruiting |
| Seoul, Korea, Republic of, 138-736 | |
| ARIAD Investigational Site #913, Younsei University Severance Hospital (Dr. Sun-Young Rha) | Recruiting |
| Seoul, Korea, Republic of, 120-752 | |
| ARIAD Investigational Site #914, Korean Cancer Center Hospital (Dr. Soo-Yong Lee) | Recruiting |
| Seoul, Korea, Republic of, 139-706 | |
| Mexico | |
| ARIAD Investigational Site #812, Centenario Hospital Miguel Hidalgo de Aguascalientes (Dr. Froylan Lopez-Lopez) | Recruiting |
| Aguascalientes, Mexico, 20230 | |
| ARIAD Investigational Site #811, Hospital General "Dr. Santiago Ramon y Cajal" ISSSTE | Withdrawn |
| Durango, Mexico, 34079 | |
| Mexico, Greater Mexico City | |
| ARIAD Investigational Site #814, Hospital General de Mexico OD (Dr. Mario Antonio Alvarez-Blanco) | Recruiting |
| Mexico City, Greater Mexico City, Mexico, 06726 | |
| Mexico, Jalisco | |
| ARIAD Investigational Site #813, Instituto Jalisciense de Cancerologia (Dr. Ana Laura Rodriguez-Garcia) | Withdrawn |
| Guadalajara, Jalisco, Mexico, 44280 | |
| ARIAD Investigational Site # 815, Hospital Angeles del Carmen (Jorge Emilio Arch-Ferrer, MD) | Recruiting |
| Guadalajara, Jalisco, Mexico, 44670 | |
| Netherlands, Limburg | |
| ARIAD Investigational Site #743, University Hospital Maastricht | Recruiting |
| Maastricht, Limburg, Netherlands, 6229 | |
| New Zealand | |
| ARIAD Investigational Site #923, Wellington Blood & Cancer Centre | Recruiting |
| Wellington, New Zealand, 6021 | |
| New Zealand, Canterbury | |
| ARIAD Investigational Site #922, Christchurch Hospital | Recruiting |
| Christchurch, Canterbury, New Zealand, 8011 | |
| New Zealand, Greater Aukland | |
| ARIAD Investigational Site #921, Auckland Hospital | Recruiting |
| Auckland, Greater Aukland, New Zealand | |
| Peru, Arequipa Region | |
| ARIAD Investigaional Site #818, Hospital Nacional Carlos Alberto Seguin Escobedo (EsSalud)-Arequipe (Dr. Herman David Moron Escobar) | Recruiting |
| Arequipa, Arequipa Region, Peru | |
| Peru, Lima | |
| ARIAD Investigational Site #817, Hospital Nacional Edgardo Rebagliatti Martins (Dr. Silvia Falcon Lizaraso) | Recruiting |
| Jesus Maria, Lima, Peru, 11 | |
| ARIAD Investigational Site #816, Instituto Nacional de Enfermedades Neoplasicas (Dr. Luis Mas Lopez) | Recruiting |
| Surquillo, Lima, Peru, 34 | |
| Poland | |
| ARIAD Investigational Site #765, Instytut Matki i Dziecka | Recruiting |
| Warsaw, Poland, 01-211 | |
| Poland, Masovia Province | |
| ARIAD Investigational Site #738, Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie | Recruiting |
| Warsaw, Masovia Province, Poland, 02-781 | |
| Romania | |
| ARIAD Investigational Site #709, Spitalul Judetean de Urgenta Sf. Loan cel Nou | Withdrawn |
| Suceava, Romania, 720237 | |
| Romania, Dolj | |
| ARIAD Investigational Site #710, Spitalul Clinic Judetean de Urgenta Craiova | Withdrawn |
| Craiova, Dolj, Romania, 200642 | |
| Romania, Hunedoara County | |
| ARIAD Investigational Site #759, Spitalul Municipal Dr. Alexandru Simionescu | Withdrawn |
| Hunedoara, Hunedoara County, Romania, 331057 | |
| Romania, Maldova | |
| ARIAD Investigational Site #711, Centrul de Oncologie Medicala | Withdrawn |
| Iasi, Maldova, Romania, 700106 | |
| Romania, Timis | |
| ARIAD Investigation Site #748, Oncomed SRL | Withdrawn |
| Timisoara, Timis, Romania, 300239 | |
| Slovakia | |
| ARIAD Investigational Site #753, Onkologicky ustav sv. Alzbety | Recruiting |
| Bratislava, Slovakia, 81250 | |
| ARIAD Investigational Site #757, Narodny Onkologicky Ustav | Recruiting |
| Bratislava, Slovakia, 83310 | |
| ARIAD Investigational Site #752, Vychodoslovensky onkologicky ustav | Recruiting |
| Kosice, Slovakia, 04191 | |
| Slovakia, Banska Bystrica | |
| ARIAD Investigational Site #764, Fakultna nemocnica s poliklinikou F.D. Roosevelt | Withdrawn |
| Banska Bysterica, Banska Bystrica, Slovakia, 97517 | |
| South Africa, Gauteng | |
| ARIAD Investigational Site #713, Mary Potter Oncology Centre | Recruiting |
| Groenkloof, Pretoria, Gauteng, South Africa, 0181 | |
| ARIAD Investigational Site #723, Pretoria Academic Hospital | Recruiting |
| Pretoria, Gauteng, South Africa, 0084 | |
| ARIAD Investigational Site #715, The Medical Oncology Centre of Rosebank | Recruiting |
| Johannesburg, Gauteng, South Africa, 2193 | |
| South Africa, Western Cape | |
| ARIAD Investigational Site #714, Groote Shuur Hospital | Recruiting |
| Cape Town, Western Cape, South Africa, 7460 | |
| Spain | |
| ARIAD Investigational Site #755, Hospital Universitario le Fe | Recruiting |
| Valencia, Spain, 46009 | |
| Spain, Balearic Islands | |
| ARIAD Investigational Site #730, Hospital Universitario Son Dureta | Recruiting |
| Palma de Mallorca, Balearic Islands, Spain, 07014 | |
| Spain, Catalonia | |
| ARIAD Investigational Site #734, Institut Catala d'Oncologia | Recruiting |
| Barcelona, Catalonia, Spain, 08907 | |
| Spain, Navarre | |
| ARIAD Investigational Site #735, Clinica Universitaria de Nevarra | Recruiting |
| Pamplona, Navarre, Spain, 31008 | |
| Spain, Tenerife | |
| ARIAD Investigational Site #712, Hospital Universitario de Canarias | Recruiting |
| La Laguna, Tenerife, Spain, 38320 | |
| Sweden, Ostergotland | |
| ARIAD Investigational Site #754, University Hospital | Recruiting |
| Linkoping, Ostergotland, Sweden, 581 | |
| Sweden, Vasterbotten | |
| ARIAD Investigational Site #722, Umea University Hospital | Recruiting |
| Umea, Vasterbotten, Sweden, 901 | |
| United Kingdom | |
| ARIAD Investigational Site #504, Cambridge University Hospitals NHS Foundation Trust Addenbrooke's Hospital | Recruiting |
| Cambridge, United Kingdom, CB2 0QQ | |
| ARIAD Investigational Site #747, Royal Marsden Hospital | Recruiting |
| London, United Kingdom, SW3 6JJ | |
| United Kingdom, Greater London | |
| ARIAD Investigational Site #720, University College London Hospital NHS Trust | Recruiting |
| London, Greater London, United Kingdom, NW1 2PG | |
| United Kingdom, North West England | |
| ARIAD Investigational Site #725, Christie Hospital NHS Trust | Recruiting |
| Manchester, North West England, United Kingdom, M20 | |
| United Kingdom, Scotland | |
| ARIAD Investigational Site #719 | Recruiting |
| Glasgow, Scotland, United Kingdom, G12 0YN | |
| United Kingdom, South East England | |
| ARIAD Investigational Site #762, Southampton General Hospital | Recruiting |
| Southampton, South East England, United Kingdom, AO16 6 YD | |
| United Kingdom, South Yorkshire | |
| ARIAD Investigational Site #749, University of Sheffield, Weston Park Hospital | Recruiting |
| Sheffield, South Yorkshire, United Kingdom, S10 2SJ | |
| United Kingdom, West Midlands | |
| ARIAD Investigational Site #721, University of Birmingham | Recruiting |
| Birmingham, West Midlands, United Kingdom, B15 2TA | |
| Study Director: | ARIAD Medical Monitor | ARIAD Pharmaceuticals, Inc. 617-494-0400 |
More Information
| Responsible Party: | ARIAD Pharmaceuticals, Inc. ( Frank Haluska, M.D. ) |
| Study ID Numbers: | AP23573-07-302 |
| Study First Received: | September 28, 2007 |
| Last Updated: | November 13, 2009 |
| ClinicalTrials.gov Identifier: | NCT00538239 History of Changes |
| Health Authority: | United States: Food and Drug Administration |
|
Sirolimus Anti-Infective Agents Neoplasms by Histologic Type Immunologic Factors Antineoplastic Agents Physiological Effects of Drugs Antibiotics, Antineoplastic Immunosuppressive Agents |
Pharmacologic Actions Anti-Bacterial Agents Neoplasms, Connective and Soft Tissue Neoplasms Therapeutic Uses Antifungal Agents Sarcoma |
