Role of Volatile Anesthetics for Hepatic Protection

This study has been completed.

First Received: August 14, 2007 Last Updated: October 22, 2009 History of Changes

Sponsor:	University of Zurich
Information provided by:	University of Zurich
ClinicalTrials.gov Identifier:	NCT00516711

Purpose

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Condition	Intervention
Reperfusion Injury	Drug: Sevoflurane

Study Type:	Interventional
Study Design:	Prevention, Randomized, Open Label, Placebo Control, Parallel Assignment, Pharmacodynamics Study
Official Title:	Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion

Resource links provided by NLM:

MedlinePlus related topics: Anesthesia

Drug Information available for: Sevoflurane

U.S. FDA Resources

Further study details as provided by University of Zurich:

Primary Outcome Measures:

Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)

Study Start Date:	March 2006
Study Completion Date:	December 2007
Primary Completion Date:	December 2007 (Final data collection date for primary outcome measure)

Detailed Description:

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Eligibility

Ages Eligible for Study:	18 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Older than 18 years of age
Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria:

Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
Liver cirrhosis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00516711

Locations

Switzerland
University Hospital of Zurich
Zurich, Switzerland

Sponsors and Collaborators

University of Zurich

Investigators

Study Director:

01 Studienregister MasterAdmins

UniversitaetsSpital Zuerich

More Information

No publications provided by University of Zurich

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Beck-Schimmer B, Breitenstein S, Urech S, De Conno E, Wittlinger M, Puhan M, Jochum W, Spahn DR, Graf R, Clavien PA. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008 Dec;248(6):909-18.

Study ID Numbers:	StV 5-2006
Study First Received:	August 14, 2007
Last Updated:	October 22, 2009
ClinicalTrials.gov Identifier:	NCT00516711 History of Changes
Health Authority:	Switzerland: Swissmedic

Keywords provided by University of Zurich:

Surgery with Pringle maneuver needed for liver resection

Additional relevant MeSH terms:

Hematologic Agents
Physiological Effects of Drugs
Vascular Diseases
Anesthetics
Central Nervous System Depressants
Pharmacologic Actions
Sevoflurane
Anesthetics, Inhalation

Pathologic Processes
Postoperative Complications
Anesthetics, General
Therapeutic Uses
Cardiovascular Diseases
Platelet Aggregation Inhibitors
Central Nervous System Agents
Reperfusion Injury

ClinicalTrials.gov processed this record on November 27, 2009