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Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2014 by Pfizer
Sponsor:
Information provided by (Responsible Party):
Pfizer
ClinicalTrials.gov Identifier:
NCT00413699
First received: December 18, 2006
Last updated: October 3, 2014
Last verified: October 2014
  Purpose

The purpose of this study is to determine the long-term effectiveness and safety of CP-690,550 for the treatment of rheumatoid arthritis. Subjects are eligible for this study only after participating in another "qualifying" study of CP-690,550

A sub-study will be conducted within the A3921024 study, this study will evaluate the immune response to pneumococcal and influenza vaccines in patients receiving CP-690,550


Condition Intervention Phase
Arthritis, Rheumatoid
Drug: CP-690,550
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Long-term, Open-label Follow-up Study Of Tofacitinib (Cp-690,550) For Treatment Of Rheumatoid Arthritis

Resource links provided by NLM:


Further study details as provided by Pfizer:

Primary Outcome Measures:
  • Primary endpoints will be standard laboratory safety data (chemistry, hematology, etc.) and adverse event (AE) reports [ Time Frame: Every visit until last observation ] [ Designated as safety issue: Yes ]
  • The long-term safety and tolerability of CP-690,550 5 mg BID and 10 mg BID for the treatment of rheumatoid arthritis [ Time Frame: Every visit until last observation ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Percent of patients with ACR 20, 50, and 70 responses [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • Area under ACR n curve [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • DAS 28 (CRP) and DAS 28 (ESR)as well as incidence of Disease Activity Score <2.6 and <3.2 [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • HAQ DI score [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • SF 36 score [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • FACIT Fatigue Scale, EuroQol EQ 5D, Work Limitations Questionnaire, and RA Healthcare Resource Utilization Questionnaire [ Time Frame: Every visit until last observation. ] [ Designated as safety issue: No ]
  • Preservation of joint structure in patients who had baseline radiographs obtained in their qualifying index study [ Time Frame: Every 6 months until last observation. ] [ Designated as safety issue: No ]
  • Vaccine sub-study endpoints: 1. % achieving a satisfactory humoral response to the pneumococcal vaccine as defined by ≥ 2-fold increase in antibody concentrations [ Time Frame: at vaccine substudy visit 2 and 4 ] [ Designated as safety issue: No ]
  • Vaccine sub-study 2. % achieving a satisfactory humoral response to the seasonal influenza vaccine as defined by ≥ 4-fold increase in antibody titers [ Time Frame: at vaccine substudy visit 2 and 4 ] [ Designated as safety issue: No ]
  • 1. Percentage of subjects achieving protective antibody titers to the seasonal influenza vaccine as measured by a hemagglutination inhibition (HI) assay titer of ≥ 1:40 in ≥ 2 of 3 influenza antigens measured at vaccine sub-study [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 2. Percentage of subjects who respond to each of the 12 pneumococcal antigens as defined by ≥ 2-fold increase in antibody concentrations from vaccine sub-study visit 2 (vaccination baseline) measured at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 3. Percentage of subjects who respond to each of the 3 influenza antigens as defined by ≥ 4-fold increase in antibody titers from vaccine sub-study visit 2 (vaccination baseline) measured at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 4. Fold increase of anti-pneumococcal antibody levels to each of the 12 pneumococcal antigens above vaccination baseline values (vaccine sub-study visit 2) at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 5. Fold increase of anti-influenza antibody levels to each of the 3 influenza antigens above vaccination baseline values (vaccine sub-study visit 2) at vaccine sub-study visit 4 [ Time Frame: at visit 2 and 4 ] [ Designated as safety issue: No ]
  • 6. Concentrations of anti-pneumococcal antibodies at vaccine sub-study visit 3 and 4 [ Time Frame: at visit 3 and 4 ] [ Designated as safety issue: No ]
  • 7. Titers of anti-influenza antibodies at vaccine sub-study visit 3 and 4 [ Time Frame: at visit 3 and 4 ] [ Designated as safety issue: No ]

Estimated Enrollment: 4385
Study Start Date: February 2007
Estimated Study Completion Date: November 2019
Estimated Primary Completion Date: November 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Open-Label Active Treatment Enrolled from Phase 2
Patients enrolling from Phase 2 studies
Drug: CP-690,550
5 mg PO BID open label; may increase to 10 mg PO BID to provide greater control of RA if no related AEs are present. May be off study drug temporarily for up to 28 days for mild to moderate AEs.
Experimental: Open-Label Active Treatment Enrolled from Phase 3
Patients enrolling from Phase 3 studies
Drug: CP-690,550
10 mg PO BID open label; may decrease to 5 mg PO BID for mild to moderate AEs. May be off study drug temporarily for up to 28 days for mild to moderate AEs.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subjects who have participated in a randomized "qualifying" study of CP-690,550 for the treatment of rheumatoid arthritis

Vaccine sub-study visit

  • Subjects actively participating in Study A3921024 must have completed at least 3 months of continuous 10 mg BID CP-690,550 treatment in A3921024 as defined by >80% compliance with prescribed dose consumption of CP-690,550 over the previous 3 months.

Exclusion Criteria:

  • Serious medical conditions that would make treatment with CP-690,550 potentially unsafe

Vaccine sub-study visit

  1. Any documented influenza or pneumococcal infection within the last 3 months prior to randomization in this study
  2. Received any vaccine within 1 month prior to randomization in this study
  3. Received an influenza vaccine within 6 months or a pneumococcal vaccine within 5 years of randomization in this study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00413699

Contacts
Contact: Pfizer CT.gov Call Center 1-800-718-1021

  Hide Study Locations
Locations
United States, Alabama
The University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Rheumatology Associates of North Alabama, P.C. Recruiting
Huntsville, Alabama, United States, 35801
United States, Arizona
ArthroCare, Arthritis Care & Research P.C. Recruiting
Gilbert, Arizona, United States, 85234
Arizona Arthritis and Rheumatology Associates, PC Recruiting
Glendale, Arizona, United States, 85304
Arizona Arthritis & Rheumatology Associates, P.C. Recruiting
Paradise Valley, Arizona, United States, 85202
Arizona Arthritis and Rheumatology Research PLLC Recruiting
Paradise Valley, Arizona, United States, 85253
Arizona Arthritis and Rheumatology Associates, PC Recruiting
Phoenix, Arizona, United States, 85037
Arizona Arthritis Research PLC Recruiting
Phoenix, Arizona, United States, 85032-9385
Radiant Research, Inc. Recruiting
Scottsdale, Arizona, United States, 85251
Catalina Pointe Clinical Research Active, not recruiting
Tucson, Arizona, United States, 85704
United States, Arkansas
Mercy Clinical Hot Springs Communities Recruiting
Hot Springs, Arkansas, United States, 71913
NEA Baptist Clinic Recruiting
Jonesboro, Arkansas, United States, 72401
Little Rock Diagnostic Clinic, P.A. Recruiting
Little Rock, Arkansas, United States, 72205
Osborne Research Center, LLC Terminated
Little Rock, Arkansas, United States, 72201
United States, California
Med Investigations Recruiting
Fair Oaks, California, United States, 95628
Office of Douglas Menzies Haselwood, MD Recruiting
Fair Oaks, California, United States, 95628
Talbert Medical Group Recruiting
Huntington Beach, California, United States, 92646
University of California San Diego Recruiting
La Jolla, California, United States, 92037
University of California San Diego Center for Innovative Therapy Recruiting
La Jolla, California, United States, 92093
University of California Recruiting
LaJolla, California, United States, 92037-0943
Keck Medicine of USC Recruiting
Los Angeles, California, United States, 90033
UCLA Medical Center Recruiting
Los Angeles, California, United States, 90095
University of California Los Angeles Recruiting
Los Angeles, California, United States, 90095
University of California Los Angeles - David Geffen School of Medicine - Division of Rheumatology Recruiting
Los Angeles, California, United States, 90095
Stanford University School of Medicine Terminated
Palo Alto, California, United States, 94304
Office of Anupama Bhat, MD Recruiting
Roseville, California, United States, 95661
Office of Douglas M. Haselwood, MD Recruiting
Roseville, California, United States, 95661
Sierra Rheumatology Recruiting
Roseville, California, United States, 95661
San Diego Arthritis Medical Clinic Recruiting
San Diego, California, United States, 92108
Pacific Arthritis Center Medical Group Recruiting
Santa Maria, California, United States, 93454
Stanford Health Services Terminated
Stanford, California, United States, 94305
Stanford Health Services GCRC Terminated
Stanford, California, United States, 94305
Stanford Investigational Pharmacy Terminated
Stanford, California, United States, 94305
Inland Rheumatology Clinical Trials Recruiting
Upland, California, United States, 91786
Inland Rheumatology Clinical Trials, Inc. Recruiting
Upland, California, United States, 91786
United States, Colorado
Boulder Medical Center, PC Recruiting
Boulder, Colorado, United States, 80304
Arthritis Associates and Osteoporosis Center of Colorado Springs Terminated
Colorado Springs, Colorado, United States, 80910
United States, Connecticut
University of Connecticut Health Center Active, not recruiting
Farmington, Connecticut, United States, 06030-5353
Arthritis & Osteoporosis Center, PC Terminated
Hamden, Connecticut, United States, 06518
New England Research Associates, LLC Recruiting
Trumbull, Connecticut, United States, 06611
United States, Delaware
Delaware Arthritis and Osteoporosis Center Active, not recruiting
Newark, Delaware, United States, 19713
United States, Florida
Arthritis and Rheumatic Disease Specialties Recruiting
Aventura, Florida, United States, 33180
Allergy, Asthma, Arthritis, & Lung Recruiting
Daytona Beach, Florida, United States, 32114
Physicians Research Alliance Terminated
Debary, Florida, United States, 32713
Southeastern Arthritis Center Active, not recruiting
Gainesville, Florida, United States, 32607
Southeastern Imaging & Diagnostics Active, not recruiting
Gainesville, Florida, United States, 32607
Southeastern Integrated Medical, PL Active, not recruiting
Gainesville, Florida, United States, 32607
Jacksonville Center for Clinical Research Recruiting
Jacksonville, Florida, United States, 32216
BayCare Outpatient Imaging at Bardmoor Recruiting
Largo, Florida, United States, 33777
Arthritis & Rheumatic Care Center Recruiting
Miami, Florida, United States, 33143
Center for Arthritis and Rheumatic Diseases Recruiting
Miami, Florida, United States, 33173
Miami Research Associates Recruiting
Miami, Florida, United States, 33143
Jeffrey Alper MD Research Recruiting
Naples, Florida, United States, 34102
Suncoast Clinical Research, Inc. Recruiting
New Port Richey, Florida, United States, 34652
Ocala Rheumatology Research Center Active, not recruiting
Ocala, Florida, United States, 34474
The Office of Jeffrey E. Poiley, MD Recruiting
Orlando, Florida, United States, 32804
Millennium Research Recruiting
Ormond Beach, Florida, United States, 32174
DMI Research, Inc. Recruiting
Pinellas Park, Florida, United States, 33782
Florida Arthritis & Osteoporosis Center Recruiting
Port Richey, Florida, United States, 34668
Lovelace Scientific Resources, Inc. Recruiting
Sarasota, Florida, United States, 34233
Sarasota Arthritis Research Center Recruiting
Sarasota, Florida, United States, 34239
St. Petersburg Arthritis Center Recruiting
St. Petersburg, Florida, United States, 33710
West Broward Rheumatology Associates, Inc. Recruiting
Tamarac, Florida, United States, 33321
Bernard Germain, MD Recruiting
Tampa, Florida, United States, 33613
Burnette & Silverfield, MDS, PLC Recruiting
Tampa, Florida, United States, 33614
Tampa Medical Group, P.A. Recruiting
Tampa, Florida, United States, 33613
Lovelace Scientific Resources Recruiting
Venice, Florida, United States, 34292
Venice Arthritis Center Recruiting
Venice, Florida, United States, 34292
Florida Medical Clinic, P.A. Recruiting
Zephyrhills, Florida, United States, 33542
United States, Georgia
Arthritis and Rheumatology of Georgia Recruiting
Atlanta, Georgia, United States, 30342
Jeffrey D. Lieberman, MD, PC Recruiting
Decatur, Georgia, United States, 30333
Marietta Rheumatology Recruiting
Marietta, Georgia, United States, 30060
United States, Idaho
St. Luke's Clinic - Rheumatology Active, not recruiting
Boise, Idaho, United States, 83702
St. Luke's Intermountain Research Center Active, not recruiting
Boise, Idaho, United States, 83702
Institute of Arthritis Research Recruiting
Idaho Falls, Idaho, United States, 83404
St. Luke's Clinic - Rheumatology Active, not recruiting
Meridian, Idaho, United States, 83642
United States, Illinois
Loyola University Medical Center Terminated
Maywood, Illinois, United States, 60153
Illinois Bone and Joint Institute, LLC Recruiting
Morton Grove, Illinois, United States, 60053
Rockford Health Physicians Terminated
Rockford, Illinois, United States, 61103-3692
Rockford Orthopedic Associates Recruiting
Rockford, Illinois, United States, 61114
The Arthritis Center Recruiting
Springfield, Illinois, United States, 62704
Deerbrook Medical Associates Recruiting
Vernon Hills, Illinois, United States, 60061
United States, Indiana
Diagnostic Rheumatology and Research PC Recruiting
Indianapolis, Indiana, United States, 46227
United States, Iowa
Physicians Clinic of Iowa Recruiting
Cedar Rapids, Iowa, United States, 52403
Medical Associates Clinic, PC Active, not recruiting
Dubuque, Iowa, United States, 52002
United States, Kansas
Via Christi Clinic, P.A. Active, not recruiting
Wichita, Kansas, United States, 67208
Professional Research Network of Kansas Recruiting
Wichita, Kansas, United States, 67203
United States, Kentucky
Bluegrass Community Reaserch, Inc. Recruiting
Lexington, Kentucky, United States, 40504
United States, Louisiana
Ochsner Clinic Foundation - Baton Rouge Recruiting
Baton Rouge, Louisiana, United States, 70809
Louisana State University Health Sciences Center Active, not recruiting
New Orleans, Louisiana, United States, 70115
Louisiana State University Health Sciences Center Active, not recruiting
New Orleans, Louisiana, United States, 70115
United States, Maine
Rheumatology Associates Recruiting
Portland, Maine, United States, 04102
United States, Maryland
Klein and Associates, MD, PA Recruiting
Cumberland, Maryland, United States, 21502
Arthritis Treatment Center Recruiting
Frederick, Maryland, United States, 21702
The Arthritis and Osteoporosis Center of Maryland Recruiting
Frederick, Maryland, United States, 21702
Center for Rheumatology and Bone Research Recruiting
Wheaton, Maryland, United States, 20902
United States, Massachusetts
Clinical Research Center of Cape Cod, Inc. Active, not recruiting
Hyannis, Massachusetts, United States, 02601
Fallon Clinic, Inc. Recruiting
Leominster, Massachusetts, United States, 01453
Fallon Clinic, Inc. Recruiting
Lincoln Street, Massachusetts, United States, 01605
Clinical Research Center of Cape Cod, Inc. Active, not recruiting
West Yarmouth, Massachusetts, United States, 02673
Clinical Pharmacalogy Study Group Recruiting
Worcester, Massachusetts, United States, 01605
Clinical Pharmacology Study Group Recruiting
Worcester, Massachusetts, United States, 01610
Fallon Clinic, Inc. at Recruiting
Worcester, Massachusetts, United States, 01608
United States, Michigan
Bronson Internal Medicine and Rheumatology Recruiting
Battle Creek, Michigan, United States, 49015
Associated Internal Medicine Specialists Recruiting
Battle Creek, Michigan, United States, 49015
Premier Imaging Center, PLC Recruiting
Bingham Farms, Michigan, United States, 48025
QUEST Research Institiute Recruiting
Bingham Farms, Michigan, United States, 48025
Borgess Internal Medicine Recruiting
Kalamazoo, Michigan, United States, 49048
Borgess Research Institute Recruiting
Kalamazoo, Michigan, United States, 49048
Borgess Rheumatology Recruiting
Kalamazoo, Michigan, United States, 49009
United States, Minnesota
Arthritis and Rheumatology Consultants, P.A. Recruiting
Edina, Minnesota, United States, 55435
United States, Mississippi
North Mississippi Medical Clinics, Inc. Recruiting
Tupelo, Mississippi, United States, 38801
United States, Missouri
University of Missouri-Columbia Recruiting
Columbia, Missouri, United States, 65212
University Physicians Recruiting
Columbia, Missouri, United States, 65203
Kansas City Internal Medicine Recruiting
Lee's Summit, Missouri, United States, 64086
United States, Nebraska
Arthritis Center of Nebraska Recruiting
Lincoln, Nebraska, United States, 68516
Physician Research Collaboration, LLC Recruiting
Lincoln, Nebraska, United States, 68516
Heartland Clinic Research, Inc. Active, not recruiting
Omaha, Nebraska, United States, 68134
Westroads Medical Group Recruiting
Omaha, Nebraska, United States, 68114
United States, New Hampshire
Dartmouth-Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Rheumatology Associates of North Jersey Active, not recruiting
Teaneck, New Jersey, United States, 07666
Arthritis, Rheumatic & Back Disease Associates Terminated
Voorhees, New Jersey, United States, 08043
United States, New York
The Center for Rheumatology, LLP Recruiting
Albany, New York, United States, 12206
Regional Rheumatology Associates Recruiting
Binghamton, New York, United States, 13905
Southern Tier Arthritis and Rheumatism Recruiting
Olean, New York, United States, 14760
Buffalo Rheumatology Recruiting
Orchard Park, New York, United States, 14127
AAIR Research Center Recruiting
Rochester, New York, United States, 14618
United States, North Carolina
Asheville Rheumatology & Osteoporosis Research Associates, P.A. Recruiting
Asheville, North Carolina, United States, 28801
Asheville Rheumatology & Osteoporosis Research Associates, PA Recruiting
Asheville, North Carolina, United States, 28803
Asheville Rheumatology and Osteoporosis Research Associates Recruiting
Asheville, North Carolina, United States, 28801
Box Arthritis & Rheumatology of the Carolinas, PLLC Recruiting
Charlotte, North Carolina, United States, 28210
PMG Research Hickory, LLC Recruiting
Hickory, North Carolina, United States, 28602
PMG Research Hickory, LLC Recruiting
Hickory, North Carolina, United States, 28601
Boice-Willis Clinic Active, not recruiting
Rocky Mount, North Carolina, United States, 27804
United States, North Dakota
Trinity Health Center - Medical Arts Recruiting
Minot, North Dakota, United States, 58701
United States, Ohio
Cincinnati Rheumatic Disease Study Group, Inc. Recruiting
Cincinnati, Ohio, United States, 45219
STAT Research, Inc. Recruiting
Dayton, Ohio, United States, 45417
The Office of Dr. Sanford M. Wolfe, D.O. - STAT Research, Inc. Recruiting
Dayton, Ohio, United States, 45417
Office of David R. Mandel, MD, Inc. Active, not recruiting
Mayfield Village, Ohio, United States, 44143
United States, Oklahoma
Lynn Health Science Institute Recruiting
Oklahoma City, Oklahoma, United States, 73112
Oklahoma Medical Research Foundation Omrf Recruiting
Oklahoma City, Oklahoma, United States, 73104
United States, Pennsylvania
East Penn Rheumatology Associates, PC Recruiting
Bethlehem, Pennsylvania, United States, 18015
Altoona Center for Clinical Research Recruiting
Duncansville, Pennsylvania, United States, 16635
Clinical Research Center of Reading, LLP Active, not recruiting
West Reading, Pennsylvania, United States, 19611
Rheumatic Disease Associates, Ltd. Recruiting
Willow Grove, Pennsylvania, United States, 19090
Clinical Research Center of Reading, LLP Active, not recruiting
Wyomissing, Pennsylvania, United States, 19610
United States, South Carolina
Palmetto Clinical at Piedmont Arthritis Recruiting
Greenville, South Carolina, United States, 29601
Piedmont Arthritis Clinic, PA Recruiting
Greenville, South Carolina, United States, 29601
Palmetto Clinical Trial Services, LLC Recruiting
Simpsonville, South Carolina, United States, 29681
United States, Tennessee
Arthritis Associates, PLLC Recruiting
Hixson, Tennessee, United States, 37343
Arthritis Clinic Recruiting
Jackson, Tennessee, United States, 38305
Rheumatology Consultants, PLLC Recruiting
Knoxville, Tennessee, United States, 37909-1907
Vanderbilt University Medical Center Active, not recruiting
Nashville, Tennessee, United States, 37203
United States, Texas
Office of John P. Lavery, MD, PA Recruiting
Allen, Texas, United States, 75013
Austin Rheumatology Research Recruiting
Austin, Texas, United States, 78705
Metroplex Clinical Research Center Recruiting
Dallas, Texas, United States, 75231
Baylor Research Institute Recruiting
Dallas, Texas, United States, 75231
Arthritis Care and Diagnostic Center, P.A. Recruiting
Dallas, Texas, United States, 75231
Presbyterian Hospital of Dallas, Arthritis Consultation Center Recruiting
Dallas, Texas, United States, 75231-4496
Radiant Research-Dallas Recruiting
Dallas, Texas, United States, 75235
University of North Texas Health Science Center at Fort Worth Terminated
Fort Worth, Texas, United States, 76107
Accurate Clinical Research, Inc. Recruiting
Houston, Texas, United States, 77034
Houston Institute for Clinical Research Recruiting
Houston, Texas, United States, 77074
Arthritis and Osteoporosis Associates, LLP Recruiting
Lubbock, Texas, United States, 79424
Southwest Rheumatology Research, LLC Recruiting
Mesquite, Texas, United States, 75150
United States, Washington
Investigational Drug Service Recruiting
Seattle, Washington, United States, 98122
Seattle Rheumatology Associates Recruiting
Seattle, Washington, United States, 98122
Virginia Mason Medical Center Terminated
Seattle, Washington, United States, 98101
Swedish Medical Center Recruiting
Seattle, Washington, United States, 98122
The Seattle Arthritis Clinic Recruiting
Seattle, Washington, United States, 98133
Swedish Clinical Research Recruiting
Seattle, Washington, United States, 98122
Tacoma Center for Arthritis Research, PS Active, not recruiting
Tacoma, Washington, United States, 98405
Tacoma Center of Arthritis Research, PS Active, not recruiting
Tacoma, Washington, United States, 98405
The Office of Robert E. Ettlinger, MD Active, not recruiting
Tacoma, Washington, United States, 98405
The Vancouver Clinic, Inc., PS Recruiting
Vancouver, Washington, United States, 98664
United States, West Virginia
Mountain State Clinical Research Recruiting
Clarksburg, West Virginia, United States, 26301
United Hospital Center Clinical Trials Office Recruiting
Clarksburg, West Virginia, United States, 26301
United States, Wisconsin
Gundersen Clinic, Ltd Recruiting
Onalaska, Wisconsin, United States, 54601
Gundersen Clinic, Ltd Recruiting
Onalaska, Wisconsin, United States, 54650
Argentina
Centro Médico Dra. De Salvo Recruiting
Buenos Aires, Argentina, C1426ABP
Consultorios Reumatológicos Pampa Active, not recruiting
Buenos Aires, Argentina, C1428DZF
Hospital Sirio Libanes Recruiting
Buenos Aires, Argentina, C1419AHN
Investigaciones Reumatologicas y Osteologicas (IRO) Recruiting
Buenos Aires, Argentina, C1114AAH
OMI - Organizacion Medica de Investigacion Recruiting
Buenos Aires, Argentina, C1015ABO
Saint Dennis Medical Group S.A. Terminated
Buenos Aires, Argentina, C1034ACO
Australia, New South Wales
Royal North Shore Hospital Recruiting
St Leonards, New South Wales, Australia, 2065
Australia, Queensland
Rheumatology Research Terminated
Cairns, Queensland, Australia, 4870
Rheumatology Research Unit Sunshine Coast Recruiting
Maroochydore, Queensland, Australia, 4558
Australia, South Australia
The Queen Elizabeth Hospital, Department of Rheumatology Recruiting
Woodville, South Australia, Australia, 5011
Australia, Victoria
Emeritus Research Recruiting
Malvern East, Victoria, Australia, 3145
Australia, Western Australia
Goatcher Clinical Research Unit Royal Perth Hospital Shenton Park Campus Recruiting
Shenton Park, Western Australia, Australia, 6008
Australia
Optimus Clinical Research Pvt. Ltd. Recruiting
Kogarah, Australia
Pharmacy Department Recruiting
St. Leonards, Australia, NSW 2065
Pharmacy Department (W) Recruiting
St. Leonards, Australia, NSW 2065
Austria
Kaiser Franz Josef Spital Active, not recruiting
Wien, Austria, 1100
Medizinische Universitaet Wien / AKH Active, not recruiting
Wien, Austria, A-1090
Rheuma-Ordination Favoriten Active, not recruiting
Wien, Austria, A-1100
Sozialmedizinisches Zentrum Sued - Kaiser Franz Josef Spital Active, not recruiting
Wien, Austria, A-1100
Belgium
Universitair Ziekenhuis Gent - Reumatologie Recruiting
Gent, Belgium, 9000
Az Groeninge Kortrijk Terminated
Kortrijk, Belgium, 8500
University of Liege Recruiting
Liege, Belgium, 4020
Bosnia and Herzegovina
University Clinical Center Sarajevo Recruiting
Sarajevo, Bosnia and Herzegovina, 71000
Brazil
CIP - Centro Internacional de Pesquisa Active, not recruiting
Goiania, GO, Brazil, 74110-120
CIP - Centro Internacional de Pesquisas Active, not recruiting
Goiania, GO, Brazil, 74110-120
Hospital Geral de Goiânia Doutor Alberto Rassi Active, not recruiting
Goiânia, GO, Brazil, 74110-120
Centro de Estudos em Terapias Inovadoras Recruiting
Curitiba, Paraná, Brazil, 80030-110
CCBR Brasil Recruiting
Rio de Janeiro, RJ, Brazil, 22271-100
CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda Recruiting
Rio de Janeiro, RJ, Brazil, 22271-100
Hospital de Clinicas de Porto Alegre Recruiting
Porto Alegre, RS, Brazil, 90035 903
Hospital de Clinicas de Porto Alegre Recruiting
Porto Alegre, RS, Brazil, 90035-903
Hospital Sao Lucas da PUCRS Recruiting
Porto Alegre, RS, Brazil, 90610-000
Hospital Alemao Oswaldo Cruz Terminated
Sao Paulo, SP, Brazil, 01323-903
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP) Recruiting
Sao Paulo, SP, Brazil, 05403-010
IMA Brasil - Instituto de Medicina Avancada Recruiting
Sao Paulo, SP, Brazil, 05437-010
CEPIC - Centro Paulista De Investigacao Recruiting
Sao Paulo, SP, Brazil, 04266-010
Bulgaria
Revmatologichen kabinet, DKTs Sv. Pantaleimon OOD Recruiting
Pleven, Bulgaria, 5800
MBAL "Kaspela" Plovdiv, Otdelenie po revmatologia Recruiting
Plovdiv, Bulgaria, 4002
Revmatologichno Otdelenie, MBAL - Plovdiv Recruiting
Plovdiv, Bulgaria, 4000
DKTs Akta Medika EOOD Recruiting
Sevlievo, Bulgaria, 5400
MBAL Sveti Ivan Rilski Sofia; Klinika po Revmatologia Recruiting
Sofia, Bulgaria, 1612
Clinic of Cardiology and Rheumatology, Military Medical Academy 3 Recruiting
Sofia, Bulgaria, 1606
Clinic of Rheumatology Multiprofile Hospital for Active treatment Sveti Ivan Rilski Recruiting
Sofia, Bulgaria, 1612
DKTs "Sveta Anna" Sofia, Recruiting
Sofia, Bulgaria, 1709
MBAL na Voennomeditsinska Akademia - Sofia, Klinika po Revmatologia i Kardiologia Recruiting
Sofia, Bulgaria, 1606
Clinic of Cardiology and Rheumatology, Military Medical Academy Recruiting
Sofia 1606, Bulgaria
MOBAL "D-r Stefan Cherkezov" AD, Revmokardiologichno otdelenie s intenziven sektor MHAT Recruiting
Veliko Tarnovo, Bulgaria, 5000
Canada, Alberta
Rheumatology Research Associates Ltd. Recruiting
Edmonton, Alberta, Canada, T5M 0H4
Canada, British Columbia
Dr. Alice Klinkhoff Inc. Active, not recruiting
Vancouver, British Columbia, Canada, V5Z 1L7
The Arthritis Research Centre of Canada Active, not recruiting
Vancouver, British Columbia, Canada, V5Z 1L7
PerCuro Clinical Research Ltd. Recruiting
Victoria, British Columbia, Canada, V8V 3P9
Canada, Manitoba
Manitoba Clinic Recruiting
Winnipeg, Manitoba, Canada, R3A 1M3
Canada, Newfoundland and Labrador
Nexus Clinical Research Recruiting
St. John's, Newfoundland and Labrador, Canada, A1A 5E8
Canada, Ontario
Burlington Rheumatology and Osteoporosis Clinic Active, not recruiting
Burlington, Ontario, Canada, L7L 0B7
Cividino Medicine Professional Corporation Recruiting
Hamilton, Ontario, Canada, L8N 2B6
Office of Dr. Fernando Bianchi Recruiting
Hamilton, Ontario, Canada, L8N 1Y2
MAC Research Inc. Recruiting
Hamilton, Ontario, Canada, L8N 2B6
Dr. William G. Bensen Medicine Professional Corporation Recruiting
Hamilton, Ontario, Canada, L8N 1Y2
KW Musculoskeletal Research Inc. Recruiting
Kitchener, Ontario, Canada, N2M 5N6
St Joseph's Health Centre Active, not recruiting
London, Ontario, Canada, N6A 4V2
Credit Valley Rheumatology Terminated
Mississauga, Ontario, Canada, L5M 2V8
The Arthritis Program Research Group Inc. Recruiting
Newmarket, Ontario, Canada, L3Y 3R7
Rheumatology Research Associates Recruiting
Ottawa, Ontario, Canada, K1H 1A2
Niagara Peninsula Arthritis Centre Inc. Recruiting
St. Catharines, Ontario, Canada, L2N 7E4
Clinical Research and Arthritis Centre Recruiting
Windsor, Ontario, Canada, N8X 5A6
Canada, Quebec
Institut de Rhumatologie de Montreal Recruiting
Montreal, Quebec, Canada, H2L 1S6
West Island Rheumatology Research Associates Active, not recruiting
Pointe-Claire, Quebec, Canada, H9R 3J1
Groupe de Recherche en Rhumatologie et Maladies Osseuses Active, not recruiting
Sainte-Foy, Quebec, Canada, G1V 3M7
Centre de Recherche Musculo-Squelettique Recruiting
Trois-Rivieres, Quebec, Canada, G8Z 1Y2
Canada, Saskatchewan
Royal University Hospital Recruiting
Saskatoon, Saskatchewan, Canada, S7H-2Z1
Canada
Centre de Traitement Specialise en Rhumatologie (C.T.S.R.) Recruiting
Quebec, Canada, G1W 4R4
Chile
Consulta Privada Dra. Lucia Ponce Active, not recruiting
Temuco, IX Region, Chile, 4790928
Hospital Base Valdivia, Servicio de Neurología Recruiting
Valdivia, Region XIV, Chile, 5090145
Centro de Diagnostico y Tratamiento San Borja Arriaran Active, not recruiting
Santiago, RM, Chile, 8360156
Centro de Estudios Reumatologicos Active, not recruiting
Santiago, RM, Chile, 7501126
Consulta Privada Dra. Marta Aliste Active, not recruiting
Santiago, RM, Chile, 7510186
Clínica Santa Maria Terminated
Providencia, Santiago, RM, Chile, 7530206
Estudios Clinicos V Region Active, not recruiting
Vina del Mar, V Region, Chile, 2570017
Hospital Regional de Rancagua Active, not recruiting
Rancagua, Chile, 2841959
Office of Dr. Pedro Miranda Active, not recruiting
Santiago, Chile
China, Guangdong
The Second Affiliated Hospital of Guangzhou Medical College Recruiting
Guangzhou, Guangdong, China, 510260
China, Hubei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting
Wuhan, Hubei, China, 430030
China, Hunan
Xiangya Hospital of Centre-south University Recruiting
Changsha, Hunan, China, 410008
China, Shandong
QiLu Hospital of Shandong University Recruiting
Jinan, Shandong, China, 250012
Qingdao Municipal Hospital Recruiting
Qingdao, Shandong, China, 266011
China, Shanghai
Shanghai Changhai Hospital Recruiting
Shanghai, Shanghai, China, 200433
China, Shanxi
Xijing Hospital, The Fourth Military Medical University Recruiting
Xi'an, Shanxi, China, 710032
China, Zhejiang
The Second Affiliated Hospital of Zhejiang University School of Medicine Recruiting
Hangzhou, Zhejiang, China, 310009
China
Beijing Chaoyang Hospital, Capital University of Medical Science Recruiting
Beijing, China, 100020
Peking University People's Hospital/Rheumatology and Immunology Department Recruiting
Beijing, China, 100044
PLA General Hospital Recruiting
Beijing, China, 100853
Si Chuan Huaxi Hospital Active, not recruiting
Chengdu, China, 610041
The Third Affiliated Hospital of Sun Yat-Sen University Recruiting
Guangzhou, China, 510630
An Hui Medical University 1st Hospital Recruiting
Hefei, China, 230022
Anhui Province Hospital Recruiting
Hefei, China, 230001
Jiangsu Province Hospital Recruiting
Nanjing, China, 210029
Rheumatology and Immunology Dept., Renji Hospital Shanghai Jiao Tong University School of Medicine Recruiting
Shanghai, China, 200001
Shanghai Changzheng Hospital Recruiting
Shanghai, China, 200003
The First Affiliated Hospital of Soochow University Recruiting
Suzhou, China, 215006
Department of Infectious Diseases & Immunology, Tianjin Medical University General Hospital Recruiting
Tianjin, China, 300052
Colombia
Centro de Reumatologia y Ortopedia Recruiting
Barranquilla, Atlantico, Colombia, 0000
Riesgo De Fractura S.A Recruiting
Bogota, Cundinamarca, Colombia, 0000
Servimed E.U. Recruiting
Bucaramanga, Santander, Colombia, 0000
Centro Integral de Reumatologia e Inmunologia S.A.S. CIREI S.A.S Recruiting
Bogota, Colombia, 0000
Costa Rica
Centro de Reumatología y Osteoporosis, Cartago Recruiting
Cartago, Costa Rica, 00000
Hospital Cima San Jose Terminated
San Jose, Costa Rica
Laboratorio CIM (Centro de Investigaciones Medicas) Terminated
San Jose, Costa Rica
Oficina Privada Del Colegio deMedicos Terminated
San Jose, Costa Rica
Croatia
University Hospital Center Osijek Recruiting
Osijek, Croatia, 31000
University Hospital Split, Department for Internal Medicine, Division of Clinical Rheumatology Recruiting
Split, Croatia, 21000
University Hospital Center Zagreb Recruiting
Zagreb, Croatia, 10000
University Hospital Center "Zagreb" Active, not recruiting
Zagreb, Croatia, 10000
Institute for physical medicine, rehabilitation and rheumatology, General Hospital "Sveti duh" Recruiting
Zagreb, Croatia, 10000
Czech Republic
X-MEDICA s.r.o. Active, not recruiting
Brno, Czech Republic, 61300
Fakultni nemocnice u sv. Anny v Brne, II. Interni klinika Active, not recruiting
Brno, Czech Republic, 656 91
FN Brno, Interni hematoonkologicka klinika Active, not recruiting
Brno, Czech Republic, 625 00
Revmacentrum MUDr. Mostera, s.r.o. Active, not recruiting
Brno - Zidenice, Czech Republic, 615 00
Ordinace revmatologa Recruiting
Ceska Lipa, Czech Republic, 470 01
MEDIPONT Plus, s.r.o. Recruiting
Ceske Budejovice, Czech Republic, 370 01
L.K.N. Arthrocentrum, s.r.o. Recruiting
Hlucin, Czech Republic, 748 01
ARTMEDI UPD s r.o. Active, not recruiting
Hostivice, Czech Republic, 253 01
Fakultni nemocnice Hradec Kralove Recruiting
Hradec Kralove, Czech Republic, 50005
Mephacentrum Recruiting
Ostrava - Poruba, Czech Republic, 70800
Revmatologicka ambulance Recruiting
Ostrava - Poruba, Czech Republic, 70800
ARTHROMED, s. r. o. Revmatologicka ambulance Active, not recruiting
Pardubice, Czech Republic, 530 02
CCBR Czech, a.s. Active, not recruiting
Pardubice, Czech Republic, 530 02
Nemocnice na Frantisku Active, not recruiting
Praha 1, Czech Republic, 11000
DC Mediscan Active, not recruiting
Praha 11 - Chodov, Czech Republic, 148 00
Institute of Rheumatology Recruiting
Praha 2, Czech Republic, 128 50
Revmatologicky ustav Recruiting
Praha 2, Czech Republic, 12850
Fakultni Thomayerova nemocnice s poliklinikou Active, not recruiting
Praha 4, Czech Republic, 140 59
Nuselska poliklinika Recruiting
Praha 4, Czech Republic, 14000
Revmatologicka ambulance Recruiting
Praha 4, Czech Republic, 140 00
Revmatologicka ambulance Active, not recruiting
Praha 4, Czech Republic, 14000
Nemocnice Atlas, a.s. Active, not recruiting
Zlin, Czech Republic, 760 01
PV-Medical s.r.o. Active, not recruiting
Zlin, Czech Republic, 760 01
Denmark
Frederiksberg Hospital Recruiting
Frederiksberg, Denmark, 2000
Dominican Republic
Centro Médico Bellas Artes Recruiting
Santo Domingo, Dominican Republic, 00000
Patricia Alvarez Site Recruiting
Santo Domingo, Dominican Republic, 00000
Finland
Helsingin Reumakeskus Oy Recruiting
Helsinki, Finland, 00120
Kiljavan Laaketutkimus Oy Recruiting
Hyvinkaa, Finland, 05800
Tampere University Hospital Terminated
Tampere, Finland, 33520
France
Hopital Nord Terminated
Amiens, France, 80054
CHR Orleans, Hopital Porte Madeleine Active, not recruiting
Orleans, France, 45000
Hôpital Saint-Antoine Active, not recruiting
Paris, France, 75012
Universite Paris Descartes - Hopital Cochin Active, not recruiting
Paris, France, 75014
Germany
Privat-Praxis, Rheumatologie (P515) Recruiting
Aachen, Germany, 52064
Ambulantes Rheumazentrum Dr. Soerensen Recruiting
Berlin, Germany, 14163
Charite Campus Mitte, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie Active, not recruiting
Berlin, Germany, 10117
Schlosspark-Klinik Innere Medizin II, Rheumatologie Recruiting
Berlin, Germany, 14059
Krankenhaus Friedrichstadt, I. Medizinische Klinik Active, not recruiting
Dresden, Germany, 01067
Universitaetsklinikum Erlangen Medizinische Klinik 3 Recruiting
Erlangen, Germany, 91054
J.W.-Goethe-Universitaetsklinik, Medizinische Klinik II, Abteilung fuer Rheumatologie Active, not recruiting
Frankfurt am Main, Germany, 60590
Schwerpunktpraxis Rheumatologie Recruiting
Halle, Germany, 06108
Schoen Klinik Hamburg-Eilbek Recruiting
Hamburg, Germany, 22081
St. Josefs-Krankenhaus, Rheumazentrum Ruhrgebiet Recruiting
Herne, Germany, 44652
Universitaetsklinikum Koeln Klinik I fuer Innere Medizin, Haus 16, 1. OG, Raum 1.008 Recruiting
Koeln, Germany, 50937
Universitaetsklinikum Leipzig AoeR, Department fuer Innere Medizin Recruiting
Leipzig, Germany, 04103
Klinikum der Universitaet Muenchen, Campus Innenstadt, Rheuma-Einheit Active, not recruiting
Muenchen, Germany, 80336
Arztpraxis, Internist - Rheumatologie Recruiting
Nuernberg, Germany, 90429
Evangelisches Fachkrankenhaus Ratingen gGmbH Recruiting
Ratingen, Germany, 40882
Schwerpunktpraxis fuer Rheumatologie Recruiting
Rheine, Germany, 48431
Universitaetsklinikum Wuerzburg Recruiting
Wuerzburg, Germany, 97080
Greece
General Hospital Euromedica "KYANOUS STAVROS" Terminated
Thessaloniki, Greece, 54636
General Army Hospital - Rheumatology unit Recruiting
Thessaloniki, Greece, 56429
General CLinic Euromedica "KYANOYS STAVROS" Terminated
Thessaloniki, Greece, 54 636
General Army Hospital Recruiting
Thessaloniki, Greece, 56429
Hungary
Drug Research Center Kft. Reumatologiai Szakrendeles Recruiting
Balatonfured, Hungary, 8230
Orszagos Reumatologiai Es Fizioterapias Intezet Recruiting
Budapest, Hungary, 1023
Revita Reumatologiai Rendelo Active, not recruiting
Budapest, Hungary, 1027
Synexus Magyarorszag Kft. Recruiting
Budapest, Hungary, H1036
MAV Korhaz es Rendelointezet, Reumatologiai szakrendeles Recruiting
Szolnok, Hungary, 5000
India
Mahavir Hospital & Research Centre Recruiting
Hyderabad, Andhra Pradesh, India, 500 004
Krishna Institute of Medical Sciences Ltd Active, not recruiting
Secunderabad, Andhra Pradesh, India, 500 003
Shalby Hospitals Ltd. Recruiting
Ahmedabad, Gujarat, India, 380054
Shalby Hospitals Recruiting
Ahmedabad, Gujarat, India, 380 015
Rheumatic Diseases Clinic Recruiting
Ahmedabad, Gujarat, India, 380009
Chanre Rheumatology & Immunology Center & Research Terminated
Bangalore, Karnataka, India, 560 079
Chanre Rheumatology & Immunology Center & Research Terminated
Bangalore, Karnataka, India, 560003
Department of Orthopedics,Shirdi Sai Hospital Active, not recruiting
Bangalore, Karnataka, India, 560 054
St. John's Medical College Hospital Active, not recruiting
Bangalore, Karnataka, India, 560 034
Arthritis Research and Care Foundation Recruiting
Pune, Maharashtra, India, 411 001
Center for Rheumatic Diseases Recruiting
Pune, Maharashtra, India, 411 001
Jehangir Clinical Development Centre Pvt. Ltd. Active, not recruiting
Pune, Maharashtra, India, 411 001
Ireland
St. Vincent's University Hospital Recruiting
Dublin, Ireland
Italy
SOD, Medicina Interna 1 e Reumatologia Recruiting
Firenze, Italy, 50139
U.O. Clinica Reumatologica Terminated
Genova, Italy, 16132
Korea, Republic of
Hanyang University Hospital, Department of Rheumatology Recruiting
Seoul, Republic Of Korea, Korea, Republic of, 133-792
Dong-A University Hospital/ Department of Pharmacy Recruiting
Busan, Korea, Republic of, 602-715
Daegu Catholic Univ Hosp Medical Center Department of Rheumatology Active, not recruiting
Daegu, Korea, Republic of, 705-718
Eulji University Hospital Internal Medicine Rheumatology Recruiting
Daejeon, Korea, Republic of, 302-799
Chonnam National University Hospital Recruiting
Gwangju, Korea, Republic of, 501-757
Inha University Hospital, Medicine/Rheumatology Recruiting
Incheon, Korea, Republic of, 400-711
Asan Medical Center Rheumatology, Internal Medicine Recruiting
Seoul, Korea, Republic of, 138-736
Asan Medical Center Recruiting
Seoul, Korea, Republic of, 442-723
Gangnam Severance Hospital/Rheumatology Recruiting
Seoul, Korea, Republic of, 135-720
Konkuk University Medical Center, Department of Rheumatology Recruiting
Seoul, Korea, Republic of, 143-729
Seoul National University Hospital Recruiting
Seoul, Korea, Republic of, 110-744
The Catholic University of Korea, Seoul St. Mary's Hospital Rheumatology, Internal Medicine Recruiting
Seoul, Korea, Republic of, 137-701
Yonsei University College of Medicine, Severance Hospital, Rheumatology, Internal Medicine Recruiting
Seoul, Korea, Republic of, 120-752
Malaysia
Queen Elizabeth Hospital Active, not recruiting
Kota Kinabalu, Sabah, Malaysia, 88586
Sunway Medical Centre Active, not recruiting
Petaling Jaya, Selangor Darul Ehsan, Malaysia, 46150
Hospital Putrajaya Active, not recruiting
Putrajaya, Wilayah Persekutan, Malaysia, 62250
Hospital Selayang Active, not recruiting
Batu Caves, Malaysia, 68100
Sarawak General Hospital Active, not recruiting
Kuching, Malaysia, 93586
Sime Darby Medical Centre Subang Jaya Sdn Bhd Recruiting
Selangor, Malaysia, 47500
Hospital Tuanku Ja'afar Active, not recruiting
Seremban, Malaysia, 70300
Mexico
Centro de Investigacion del Noroeste S.C. Recruiting
Tijuana, Baja California, Mexico, 22010
Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC Recruiting
Torreon, Coahuila, Mexico, 27000
Centro de Investigacion y Tratamiento Reumatologico S.C. Recruiting
Mexico, D.f., Mexico, 11850
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Recruiting
Mexico, DF, Mexico, 14000
Centro Medico Toluca Recruiting
Metepec, Estado de Mexico, Mexico, 52140
Unidad de Investigacion en Enfermedades Cronico Degenerativas Recruiting
Guadalajara, Jalisco, Mexico, 44620
Centro de Investigacion Clinica Especializada, SC Recruiting
Coyoacan, Mexico D.F., Mexico, 04030
Star Medica Centro de Investigacion Clinica de Morelia Recruiting
Morelia, Michoacan, Mexico, 58070
INOVAMED Hospital Recruiting
Cuernavaca, Morelos, Mexico, 62270
Hospital Universitario Jose Eleuterio Gonzalez Recruiting
Monterrey, Nuevo Leon, Mexico, 64020
Centro Medico de las Americas Recruiting
Merida, Yucatan, Mexico, 97000
Hospital Christus Muguerza del Parque Recruiting
Chihuahua, Mexico, 31000
Instituto Jaliscience de Investigación Clínica SA de CV Recruiting
Guadalajara, Mexico, 44160
Hospital Angeles del Pedregal Recruiting
Mexico, Mexico, 10700
Hospital Angeles Mocel Recruiting
Mexico City, Mexico, 11850
Clinica de Enfermedades Cronicas y de Procedimientos Especiales (CECYPE) Recruiting
Morelia, Mexico, 58249
Fundacion El Hospitalito Recruiting
Morelos, Mexico, 62170
Centro Reumatologico de Queretaro Recruiting
Queretaro, Mexico, 76178
Hospital Central Dr. Ignacio Morones Prieto Unidad Regional de Reumatologia y Osteoporosis Recruiting
San Luis Potosi, Mexico, 78240
Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi S.C. Consultorio 600 6to Piso Recruiting
San Luis Potosi, Mexico, 78200
New Zealand
The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital Recruiting
Christchurch, New Zealand, 8022
Waikato Hospital, Rheumatology Recruiting
Hamilton, New Zealand, 3204
Timaru Rheumatology Studies Recruiting
Timaru, New Zealand, 7910
Peru
Hospital Nacional IV Alberto Sabogal Sologuren Recruiting
Callao, Peru, C-02
Centro Medico Corpac/Investigaciones en Reumatologia Recruiting
Lima, Peru, L-27
Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR Recruiting
Lima, Peru, L-27
Philippines
Mary Mediatrix Medical Center Recruiting
Lipa City, Batangas, Philippines, 4217
1. De La Salle University Health Sciences Campus Clinical Epidemiology Unit Terminated
Dasmarinas, Cavite, Philippines, 4114
Angeles University Foundation Medical Center Recruiting
Angeles, Pampanga, Philippines, 2009
University of Santo Tomas Hospital Recruiting
Manila, Phillipines, Philippines, 1008
Chong Hua Medical Arts Building Active, not recruiting
Cebu City, Philippines, 6000
Southern Philippines Medical Center (SPMC) (Davao Medical Center (DMC)) Recruiting
Davao, Philippines, 8000
Section of Rheumatology Recruiting
Davao City, Philippines, 8000
University of Perpetual Help Terminated
Las Piñas City, Philippines, 1742
Brokenshire Integrated Health Ministries, Recruiting
Madapo, Philippines
Hospital Research Center, University of Santo Tomas Hospital Recruiting
Manila, Philippines, 1008
Rayuma Klinik, OPD Jose R. Reyes Memorial Medical Center Not yet recruiting
Manila, Philippines, 1003
Poland
NZOZ "Osteo-Medic"s.c. Artur Racewicz, Jerzy Supronik Recruiting
Bialystok, Poland, 15-354
NZOZ i Chorob Kostno-Stawowych J. Badurski Sp.J ul Recruiting
Bialystok, Poland, 15- 879
ZDROWIE OSTEO-MEDIC s. c. Recruiting
Bialystok, Poland, 15-354
Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Medicus Recruiting
Cieszyn, Poland, 43-400
Szpital im. Teodora Dunina Recruiting
Koscian, Poland, 64-000
Krakowskie Centrum Medyczne NZOZ Recruiting
Krakow, Poland, 31-501
Centrum Badan Klinicznych s.c. Wieslawa Porawska, Lukasz Porawski Recruiting
Poznan, Poland, 60-773
Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko Recruiting
Sopot, Poland, 81-759
Nzoz "Nasz Lekarz" Recruiting
Torun, Poland, 87-100
Lecznica Specjalistow, Centrum Medyczne "Osteomed" NZOZ Recruiting
Warszawa, Poland, 02-256
Rheuma Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy Recruiting
Warszawa, Poland, 02-118
SYNEXUS SCM Sp. z o.o. Recruiting
Warszawa, Poland, 01-192
SYNEXUS Polska Sp. z.o.o. Recruiting
Wroclaw, Poland, 50-088
Puerto Rico
Edificio Parra Recruiting
Ponce, Puerto Rico, 00717
Ponce School of Medicine Recruiting
Ponce, Puerto Rico, 00716
San Juan Arthritis & Research Center Recruiting
San Juan, Puerto Rico, 00918
Romania
Spitalul Clinic "Sf. Maria" Recruiting
Bucuresti, Romania, 011172
Spitalul de Recuperare Iasi Recruiting
Iasi, Romania, 700661
Russian Federation
Consultative and Diagnostic Rheumatological Center "Healthy Joints", LLC Recruiting
Novosibirsk, Novosibirsk Region, Russian Federation, 630091
State Healthcare Institution Regional Clinical Hospital Recruiting
Barnaul, Russian Federation, 656024
State Educational Institution of Higher Professional Education Recruiting
Ekaterinburg, Russian Federation, 620149
State Healthcare Institution Recruiting
Ekaterinburg, Russian Federation, 620102
Kemerovo Regional Veterans Hospital Recruiting
Kemerovo, Russian Federation, 650099
Rheumatology Research Institute of Russian Academy of Medical Sciences Recruiting
Moscow, Russian Federation, 115522
Russian State Medical University Moscow Faculty City Clinical Hospital #4 Active, not recruiting
Moscow, Russian Federation, 115093
GUZ Republican Hospital V.A.Baranov Recruiting
Petrozavodsk, Russian Federation, 185019
Republican Hospital n. a. V.A.Baranov Recruiting
Petrozavodsk, Russian Federation, 185019
Almazov Federal Heart, Blood and Endocrinology Centre Recruiting
Saint-Petersburg, Russian Federation, 197341
State Educational Institution of Higher professional education Smolensk State Medical Academy Recruiting
Smolensk, Russian Federation, 214019
Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency Recruiting
St. Petersburg, Russian Federation, 194291
St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85 Recruiting
St. Petersburg, Russian Federation, 198260
State Health Institution City Hospital # 25, City Rheumatology Center of St. Petersburg Recruiting
St. Petersburg, Russian Federation, 190068
State Healthcare Institution City Hospital # 40 of Administrative Health Resort District Recruiting
St.Petersburg, Russian Federation, 197706
Regional State Budgetary Healthcare Institution of Tomsk Regional Clinical Hospital Recruiting
Tomsk, Russian Federation, 634063
Slovakia
Reumatologicka ambulancia, Poliklinika Ruzinov Recruiting
Bratislava, Slovakia, 82606
NOVAPHARM s.r.o -Zeleznicna NaP, Reumatologicka ambulancia Active, not recruiting
Bratislava, Slovakia, 832 99
AAGS, s.r.o. , nestatne zdravotnicke zariadenie,Dept. of Rheumatology Recruiting
Dunajska Streda, Slovakia, 92901
Interna a reumatologicka ambulancia Recruiting
Kosice, Slovakia, 040 01
Ecclesia, s.r.o Reumatologicka ambulancia Recruiting
Nove Zamky, Slovakia, 94001
Narodny ustav reumatickych chorob Recruiting
Piestany, Slovakia, 921 01
Reumatologicka ambulancia, MUDr. Zuzana Cizmarikova, s.r.o. Recruiting
Poprad, Slovakia, 058 01
Reumatologicka ambulancia, REUMEX, s.r.o. Recruiting
Rimavska Sobota, Slovakia, 979 01
Reumatologicka ambulancia, Nestatne zdravotnicke zariadenie Recruiting
Senica, Slovakia, 905 01
NsP Zilina Recruiting
Zilina, Slovakia, 012 07
Spain
Hospital Clinico Universitario de Santiago Recruiting
Santiago de Compostela, A Coruña, Spain, 15706
Hospital de Merida Recruiting
Merida, Badajoz, Spain, 06800
Hospital Universitario Marques de Valdecilla (HUMV) Recruiting
Santander, Cantabria, Spain, 39008
Hospital El Tomillar Terminated
Dos Hermanas, Sevilla, Spain, 41700
Hospital Universitario Cruces Recruiting
Barakaldo, Vizcaya, Spain, 48903
Hospital de Basurto Recruiting
Bilbao, Vizcaya, Spain, 48013
Hospital Del Mar Active, not recruiting
Barcelona, Spain, 08003
Complexo Hospitalario Universitario de A Coruna LABORATORIO DE INVESTIGACION Recruiting
La Coruna, Spain, 15006
Hospital 12 de Octubre Recruiting
Madrid, Spain, 28041
Hospital Universitario De La Paz Recruiting
Madrid, Spain, 28046
Hospital Civil. Hospital Regional Universitario Carlos Haya Recruiting
Malaga, Spain, 29009
Hospital Nuestra Senora de La Esperanza Recruiting
Santiago de Compostela, Spain, 15705
Hospital Nuestra Señora de Valme Terminated
Sevilla, Spain, 41014
Hospital Universitario Virgen Macarena Recruiting
Sevilla, Spain, 41009
Hospital Universitari i Politecnic La Fe de Valencia Terminated
Valencia, Spain, 46026
Sweden
Falu Lasarett Medicinkliniken Active, not recruiting
Falun, Sweden, 791 82
Lanssjukhuset Ryhov, Ortoped- och reumatologkliniken Recruiting
Jonkoping, Sweden, 551 85
Sjukhusapoteket Jonkoping Recruiting
Jonkoping, Sweden, 55185
Skanes Universitetssjukhus i Malmo Recruiting
Malmo, Sweden, 205 02
Sundsvalls Sjukhus Medicinkliniken Lasarettsvã"Gen 21 Recruiting
Sundsvall, Sweden, 851 86
Norrlands Universitetssjukhus Active, not recruiting
Umea, Sweden, 901 85
Akademiska University Hospital Recruiting
Uppsala, Sweden, 75185
Taiwan
Chang Gung Medical Foundation-Kaohsiung Branch/Division of Allergy, Immunology and Rheumatology Recruiting
Niao Sung Hsiang, Kaohsiung County, Taiwan, 833
Chang Gung Memorial Hospital Kaohsiung branch Recruiting
Niao Sung Hsiang, Kaohsiung County, Taiwan, 833
Changhua Christian Hospital Active, not recruiting
Changhua, Taiwan, 500
Chang Gung Medical Foudation Kaohsiung Branch Recruiting
Kaohsiung, Taiwan, 833
Chang Gung Medical Foundation, Kaohsiung Branch Recruiting
Kaohsiung, Taiwan, 833
Kaohsiung Medical University,Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Kaohsiung Veterans General Hospital Recruiting
Kaohsiung, Taiwan, 813
Chang Gung Medical Foundation-Kaohsiung Branch, Department of Pharmacy Recruiting
Kaohsiung County, Taiwan, 83301
Chang Gung Medical Foundation-Linkou Branch Recruiting
Kwei-Shan, Taiwan, 333
Taichung Veterans General Hospital Active, not recruiting
Taichung, Taiwan, 40705
National Cheng Kung University Hospital Recruiting
Tainan, Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10018
Taipei Veterans General Hospital Recruiting
Taipei, Taiwan, 11217
Thailand
Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital Recruiting
Phayathai, Bangkok, Thailand, 10400
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Recruiting
Amphoe Mueang, Chiang Mai, Thailand, 50200
Siriraj Hospital, Mahidol University Recruiting
Bangkok, Thailand, 10700
Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital Recruiting
Bangkok, Thailand, 10400
Allergy Immunology Rheumatology Division,Department of Medicine, Faculty of Medicine Recruiting
Khon Kaen, Thailand, 40002
Turkey
Hacettepe University Faculty of Medicine Active, not recruiting
Ankara, Turkey, 06100
Hacettepe University Medical Faculty Internal Diseases Department Rheumatology Division Active, not recruiting
Ankara, Turkey, 06100
Dokuz Eylul University Medical Faculty Internal Diseases Department Rheumatology Division Recruiting
Izmir, Turkey, 35340
Ege University Medical Faculty Internal Diseases Department Rheumatology Division Active, not recruiting
Izmir, Turkey, 35100
Ukraine
CRI "Clinical Territorial Medical Association "University Clinic", Department of Rheumatology Recruiting
Simferopol, Crimea, Ukraine, 95017
Municipal Establishment of Health Care Recruiting
Kharkiv, Ukraine, 61178
State Establishment "Institute of Gerontology of NAMS of Ukraine n.a. D.F. Chebotareva", Recruiting
Kyiv, Ukraine, 04114
State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine Recruiting
Kyiv, Ukraine, 04053
Municipal City Clinical Hospital #4, Policlinic Care, Family Medicine and Dermatology Recruiting
Lviv, Ukraine, 79011
Municipal Establishment City Clinical Hospital #9 n.a. O.I. Minakov, Department of Rheumatology Recruiting
Odesa, Ukraine, 65026
Vinnitsa Regional Clinical Hospital n.a. Pirogov Recruiting
Vinnitsa, Ukraine, 21018
City Hospital #7, Department of Internal Diseases #2 of Zaporizhzhia State Medical University Recruiting
Zaporizhzhia, Ukraine, 69118
United Kingdom
University Hospital Aintree Not yet recruiting
Liverpool, Merseyside, United Kingdom, L9 7AL
Arrowe Park Hopsital Recruiting
Wirral, Merseyside, United Kingdom, CH49 5PE
Cannock Chase Hospital/Mid Staffordshire General Hospitals NHS Trust Recruiting
Cannock, Mid Staffordshire, United Kingdom, WS11 2XY
The Dudley Group of Hospitals (DGOH) NHS Foundation Trust - Russells Hall Hospital Recruiting
Dudley, United Kingdom, DY1 2HQ
Royal Victoria Infirmary Recruiting
Newcastle Upon Tyne, United Kingdom, NE1 4LP
Sponsors and Collaborators
Pfizer
Investigators
Study Director: Pfizer CT.gov Call Center Pfizer
  More Information

Additional Information:
No publications provided

Responsible Party: Pfizer
ClinicalTrials.gov Identifier: NCT00413699     History of Changes
Other Study ID Numbers: A3921024, 2006-005035-19
Study First Received: December 18, 2006
Last Updated: October 3, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Pfizer:
long-term
open-label
safety

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Autoimmune Diseases
Connective Tissue Diseases
Immune System Diseases
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Tofacitinib
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protein Kinase Inhibitors

ClinicalTrials.gov processed this record on November 24, 2014