Insulin Resistance and Hypertensive Disorders in Pregnancy

This study has been completed.

First Received: December 15, 2006 Last Updated: February 17, 2009 History of Changes

Sponsor:	University of Messina
Information provided by:	University of Messina
ClinicalTrials.gov Identifier:	NCT00412230

Purpose

The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester. Furthermore, markers of vascular and placental injuries, of oxidative stress and inflammation will be evaluated.

Condition
Hypertension in Pregnancy Diabetes Mellitus in Pregnancy

Study Type:	Observational
Study Design:	Case Control, Retrospective
Official Title:	The Role of Insulin Resistance in Gestational Hypertension and in Preeclampsia.

Resource links provided by NLM:

MedlinePlus related topics: Diabetes Diabetes and Pregnancy High Blood Pressure High Blood Pressure in Pregnancy

Drug Information available for: Insulin

U.S. FDA Resources

Further study details as provided by University of Messina:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	100
Study Start Date:	October 2006
Study Completion Date:	June 2008

Groups/Cohorts
no treatment
2

Eligibility

Ages Eligible for Study:	18 Years to 45 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

pregnant outpatients

Criteria

Inclusion Criteria:

PCOS, BMI>/=30
previous pregnancy affected by hypertension or gestational diabetes
thrombophilia
Type I or II diabetes mellitus
autoimmune diseases
twin pregnancy
renal diseases
previous pre-eclampsia in relatives

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00412230

Locations

Italy
University Hospital
Messina, Italy, 98121
University Hospital
Messina, Italy, 98121

Sponsors and Collaborators

University of Messina

Investigators

Principal Investigator:

Rosario D'Anna, Associate Professor

University of Messina

More Information

No publications provided

Responsible Party:	University of Messina ( Rosario D'Anna )
Study ID Numbers:	120254
Study First Received:	December 15, 2006
Last Updated:	February 17, 2009
ClinicalTrials.gov Identifier:	NCT00412230 History of Changes
Health Authority:	Italy: Ministry of Health

Keywords provided by University of Messina:

Pre-eclampsia
Gestational diabetes
Insulin resistance
hypertension in pregnancy

Additional relevant MeSH terms:

Metabolic Diseases
Pregnancy Complications
Physiological Effects of Drugs
Diabetes Mellitus
Vascular Diseases
Pre-Eclampsia
Endocrine System Diseases
Pharmacologic Actions
Insulin

Hyperinsulinism
Hypertension, Pregnancy-Induced
Hypoglycemic Agents
Cardiovascular Diseases
Insulin Resistance
Glucose Metabolism Disorders
Pregnancy in Diabetics
Hypertension

ClinicalTrials.gov processed this record on November 25, 2009