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BOSS Study: A Study of Fuzeon Using the Needle-Free Biojector 2000 in Patients With HIV-1 Infection

This study has been completed.
Sponsor:
Collaborator:
Trimeris
Information provided by (Responsible Party):
Hoffmann-La Roche
ClinicalTrials.gov Identifier:
NCT00337701
First received: June 15, 2006
Last updated: November 3, 2014
Last verified: November 2014
  Purpose

This study will evaluate the signs and symptoms associated with Fuzeon injection (90mg sc) using the B2000 needle-free injection device, in HIV-1 positive patie nts experienced to Fuzeon treatment, but having difficulty tolerating long-term (>4 weeks) administration of Fuzeon with the standard needle and syringe. Patien ts will be randomized to the B2000 device or the standard needle and syringe for 4 weeks; all patients will use the B2000 device for the next 4 weeks. The antic ipated time on study treatment is <3 months, and the target sample size is 100-5 00 individuals.


Condition Intervention Phase
HIV Infections
Drug: enfuvirtide [Fuzeon]
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Biojector 2000 Open-Label Safety Study (BOSS) to Evaluate Signs and Symptoms Associated With a Needle-free Injection Device for Administration of Fuzeon to Patients With HIV-1 Infection

Resource links provided by NLM:


Further study details as provided by Hoffmann-La Roche:

Primary Outcome Measures:
  • Composite endpoint (pain, induration, nodules/cysts) [ Time Frame: Throughout study ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • AEs and ISRs [ Time Frame: Throughout study ] [ Designated as safety issue: No ]

Enrollment: 326
Study Start Date: June 2006
Study Completion Date: January 2007
Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Drug: enfuvirtide [Fuzeon]
90mg sc bid by Biojector 2000 NFID for 8 weeks
Experimental: 2 Drug: enfuvirtide [Fuzeon]
90mg sc bid by standard needle and syringe for 4 weeks, followed by 90mg sc bid by Biojector 2000 NFID for 4 weeks.

  Eligibility

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • adult patients >=16 years of age;
  • current or former Fuzeon user who may benefit from needle-free administration of Fuzeon;
  • naive to use of the B2000 device;
  • positive test results for human immunodeficiency virus infection.

Exclusion Criteria:

  • patients naive to Fuzeon;
  • inability to self-inject Fuzeon, or no reliable caregiver to administer injections;
  • evidence of active, untreated, opportunistic infections.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00337701

  Hide Study Locations
Locations
United States, Alabama
Birmingham, Alabama, United States, 35294-2050
United States, Arizona
Phoenix, Arizona, United States, 85006
Phoenix, Arizona, United States, 85012
United States, California
Fountain Valley, California, United States, 92708
Hayward, California, United States, 94545
Long Beach, California, United States, 90813
Los Angeles, California, United States, 90036
Palm Springs, California, United States, 92262
San Francisco, California, United States, 94115
Santa Clara, California, United States, 95051
United States, Colorado
Denver, Colorado, United States, 80220
United States, Florida
Fort Lauderdale, Florida, United States, 33316
Fort Myers, Florida, United States, 33901
North Miami Beach, Florida, United States, 33169
Orlando, Florida, United States, 32803
Plantation, Florida, United States, 33317
Port St Lucie, Florida, United States, 34952
Tampa, Florida, United States, 33614
United States, Georgia
Atlanta, Georgia, United States, 30318
Decatur, Georgia, United States, 30033
United States, Idaho
Boise, Idaho, United States, 83704
United States, Illinois
Chicago, Illinois, United States, 60657
United States, Maryland
Baltimore, Maryland, United States, 21201
Silver Spring, Maryland, United States, 20910
United States, Massachusetts
Boston, Massachusetts, United States, 02215-3318
United States, Michigan
Berkley, Michigan, United States, 48072-1550
United States, Missouri
St Louis, Missouri, United States, 63139
St Louis, Missouri, United States, 63117
United States, New Jersey
Somers Point, New Jersey, United States, 08244
Voorhees, New Jersey, United States, 08043
United States, New York
New York, New York, United States, 10016
New York, New York, United States, 10011
Rochester, New York, United States, 14604
United States, North Carolina
Winston-salem, North Carolina, United States, 27103
United States, Oregon
Portland, Oregon, United States, 97209-2534
United States, Pennsylvania
Philadelphia, Pennsylvania, United States, 19107
United States, Texas
Fort Worth, Texas, United States, 76104
Galveston, Texas, United States, 77555
Houston, Texas, United States, 77098
Houston, Texas, United States, 77027
United States, Virginia
Hampton, Virginia, United States, 23666
United States, Washington
Spokane, Washington, United States, 99204
Puerto Rico
Ponce, Puerto Rico, 00717-1563
Santurce, Puerto Rico, 00909
Sponsors and Collaborators
Hoffmann-La Roche
Trimeris
Investigators
Study Director: Clinical Trials Hoffmann-La Roche
  More Information

No publications provided

Responsible Party: Hoffmann-La Roche
ClinicalTrials.gov Identifier: NCT00337701     History of Changes
Other Study ID Numbers: ML19849
Study First Received: June 15, 2006
Last Updated: November 3, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome
Communicable Diseases
HIV Infections
Infection
Immune System Diseases
Immunologic Deficiency Syndromes
Lentivirus Infections
RNA Virus Infections
Retroviridae Infections
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Viral
Slow Virus Diseases
Virus Diseases
Enfuvirtide
Anti-HIV Agents
Anti-Infective Agents
Anti-Retroviral Agents
Antiviral Agents
HIV Fusion Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on November 19, 2014