DISEASE CHARACTERISTICS:

• Histologically confirmed adenocarcinoma of the prostate
• Must have completed prior surgery, cryotherapy, or radiotherapy for the primary tumor

• Documented rising prostate-specific antigen (PSA)

  • Absolute level of PSA > 0.2 ng/mL after surgery
  • Absolute level of PSA > 1.0 ng/mL after radiation or cryotherapy
  • Absolute level of PSA ≥ 0.4 ng/mL after multiple treatment modalities (e.g., surgery with radiotherapy or radiotherapy with cryotherapy)
  • PSA must be ≥ 100% above best nadir achieved

  • PSA doubling time > 3 months or ≤ 24 months

    • Patients must have ≥ 3 rising PSA time points above the minimum nadir achieved over ≥ 6 months

      • The interval between PSA time points must be > 2 weeks
• PSA ≤ 7.0 ng/mL
• Patients who underwent radical prostatectomy and never achieved undetectable serum PSA after surgery are not eligible
• Gleason score ≤ 7
• No histologically positive lymph nodes
• No evidence of metastatic disease by physical examination, CT scan, or bone scan

PATIENT CHARACTERISTICS:

• Life expectancy ≥ 6 months
• ECOG performance status 0 or 1
• No significant concomitant medical or psychiatric conditions that would limit study compliance
• No known allergies to pomegranate extract

• No known diabetes with hemoglobin A_1c level > 7.0% in the past 3 months

  • Diabetic patients entering study who have not had hemoglobin A_1c level measured in the past 3 months must have levels measured at study initiation
• No clinically abnormal laboratory values > 2 times the upper limit of normal

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• More than 4 weeks since prior and no concurrent experimental drugs, high-dose steroids, or other cancer treatment

• No hormonal therapy, with the exception of neoadjuvant androgen-deprivation therapy (ADT), prior to or concurrent with primary therapy

  • Patients who received prior neoadjuvant ADT must have serum testosterone ≥ 150 ng/dL
• No prior or concurrent hormonal therapy for rising PSA after primary therapy for prostate cancer
• No finasteride or dutasteride at any time point after primary therapy and during study therapy
• No other concurrent commercial pomegranate products
• No other concurrent systemic or local therapy for prostate cancer
• Concurrent dietary/herbal supplements (e.g., saw palmetto or selenium) allowed provided dose has been stable for ≥ 2 months prior to study entry and there are no plans to change or stop the supplements during study therapy