Efficacy of the HCVIDDOXIL Regimen in Patients With Newly Diagnosed Peripheral T-Cell Lymphoma
The goal of this clinical research study is to learn if treatment with two types of chemotherapy combinations can help to control peripheral T-cell lymphoma.
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||A Phase II Study of the Efficacy of the HCVIDDOXIL Regimen in Patients With Newly Diagnosed Peripheral T Cell Lymphoma|
- Time to Disease Progression [ Time Frame: Baseline and response assessments every 2 cycles (cycle is 21 days) ] [ Designated as safety issue: No ]
|Study Start Date:||September 2003|
|Estimated Study Completion Date:||September 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Experimental: HCVIDDOXIL Regimen
HCVIDDOXIL Regimen = Cyclophosphamide, Mesna, Doxil, Vincristine, Dexamethasone
300 mg/m^2 IV Over 3 Hours Twice Daily on Days 1, 2, and 3.
Other Names:Drug: Mesna
600 mg/m^2 IV Continuous Infusion Over Days 1, 2, and 3.Drug: Vincristine
1.4 mg/m^2 IV On Day 4 and 11.Drug: Methotrexate
200 mg/m^2 IV Over 2 Hours on Day 1, followed by 800 mg/m^2 IV Over 22 Hours on Day 1.Drug: Ara-C
3 Gm/m^2 Over 2 Hours Twice Daily On Days 2 and 3.
Other Names:Drug: Dexamethasone
40 mg IV or by mouth daily on Days 1-4 and 11-14.
Other Name: DecadronDrug: G-CSF
300 mcg subcutaneously 24 hours after end of Day 4 vincristine.
Other Names:Drug: Doxil
25 mg/m^2 IV Over 1 Hour on Day 2.
Hide Detailed Description
All of the drugs used in this study are commonly used in the treatment of cancer. However, using these drugs in combination is investigational.
During treatment, you will be given two different cycles of chemotherapy, which will be alternated every 21 days.
For Cycle 1, cyclophosphamide will be given by vein two times a day on Days 1,2, and 3. Each dose will take around 3 hours to give. Mesna will be given by vein nonstop over Days 1 through 3. Pegylated liposomal doxorubicin will be given by vein over 1 hour on Day 2. Vincristine will be given by vein on Days 4 and 11. Dexamethasone will be given by mouth on Days 1 through 4 and 11 through 14. Other drugs will be given before, during, and after chemotherapy to help decrease the risk of developing side effects. These drugs may be given by mouth or by injection.
For Cycle 2, methotrexate will be given by vein over 2 hours on Day 1 and over 22 hours on day 1. Cytarabine will be given by vein twice a day on Days 2 and 3. Each dose will take about 2 hours to give. Other drugs will be given before, during, and after treatment to help decrease the risk of developing side effects. These drugs may be given by mouth or by injection.
To help increase the blood counts and help decrease the risk of developing infections, your doctor may decide that treatment with filgrastim is necessary. Filgrastim may be given as once-a-day injections under the skin starting 24 hours after the end of Day 4 vincristine (Cycle 1) and starting 24 hours after the end of Cytarabine (Cycle 2). Your blood counts will be monitored and filgrastim is stopped when the levels become normal.
Cycles 1 and 2 will be alternated every 21 days. Both Cycles 1 and 2 can be given on an outpatient basis if your physician authorizes it. However, if your serum creatinine (blood test) reaches a certain level, Cycle 2 should be given on an inpatient basis.
Depending on how the disease responds, treatment may be stopped after 2,4, or 6 cycles. However, treatment may continue for up to 8 cycles.
During treatment, you will have around 2-3 tablespoons of blood collected at least once a week for routine tests.
After every 2 cycles, tumors will be measured using x-rays or other scans (CT, MRI, etc.) and bone marrow samples will be taken. Heart scans or heart function tests may also be needed if you doctor feels it is necessary.
If the disease gets worse or you experience any intolerable side effects, you will be taken off the study and your doctor will discuss other treatment options with you.
After the last cycle of chemotherapy, you will have follow-up exams scheduled. During these exams, you will have a chest x-ray and CT scans of the chest, abdomen (stomach) and pelvis (waist area), and PET scan. You will have blood collected (2-3 tablespoons) for routine tests. If your doctor feels it is necessary, you may also have a sample of bone marrow collected. You may choose to have long-term follow-up exams at M. D. Anderson or with your local physician.
This is an investigational study. All of the study drugs are approved by the FDA for cancer treatment and are commercially available. However, the use of the drugs in combination is experimental. Up to 55 participants will take part in this study. All will be enrolled at UT MD Anderson Cancer Center.
|United States, Texas|
|University of Texas MD Anderson Cancer Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Yasuhiro Oki, MD||M.D. Anderson Cancer Center|