Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2009 by The Parkinson's Institute.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
The Parkinson's Institute
ClinicalTrials.gov Identifier:
NCT00282802
First received: January 26, 2006
Last updated: July 1, 2009
Last verified: July 2009
  Purpose

The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.


Condition
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Twins and the Risk of PD: A Clinical and Imaging Study

Resource links provided by NLM:


Further study details as provided by The Parkinson's Institute:

Primary Outcome Measures:
  • Onset of Parkinson's disease [ Time Frame: duration of the project ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Age of Parkinson's disease onset [ Time Frame: duration of the project ] [ Designated as safety issue: No ]

Estimated Enrollment: 250
Study Start Date: April 2001
Estimated Study Completion Date: July 2010
Groups/Cohorts
1
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort

Detailed Description:

Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.

The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.

The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.

The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.

Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.

  Eligibility

Ages Eligible for Study:   77 Years to 88 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort

Criteria

Inclusion:

  • Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00282802

Locations
United States, California
The Parkinson's Institute, 675 Almanor Avene
Sunnyvale, California, United States, 94085
Sponsors and Collaborators
The Parkinson's Institute
Investigators
Principal Investigator: Caroline M. Tanner, MD The Parkinson's Institute
  More Information

No publications provided

Responsible Party: Caroline M. Tanner, MD, PhD, Director of Clinical Research, The Parkinson's Institute
ClinicalTrials.gov Identifier: NCT00282802     History of Changes
Other Study ID Numbers: R01NS40467, R01 NS 40467-01
Study First Received: January 26, 2006
Last Updated: July 1, 2009
Health Authority: United States: Federal Government

Keywords provided by The Parkinson's Institute:
Parkinson's Disease
twins
SPECT
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort Registry
NAS/NRC
World War II Veteran Twins

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases

ClinicalTrials.gov processed this record on September 15, 2014