Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With Stage III or Stage IV Head and Neck Cancer
This study is ongoing, but not recruiting participants.
Sponsor:
Radiation Therapy Oncology Group
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00265941
First received: December 14, 2005
Last updated: September 8, 2011
Last verified: September 2009
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Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cisplatin may also make tumor cells more sensitive to radiation therapy. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving radiation therapy and cisplatin together with cetuximab may kill more tumor cells. It is not yet known whether radiation therapy and cisplatin are more effective with or without cetuximab in treating head and neck cancer.
PURPOSE: This randomized phase III trial is studying radiation therapy, cisplatin, and cetuximab to see how well they work compared to radiation therapy and cisplatin in treating patients with stage III or stage IV head and neck cancer.
| Condition | Intervention | Phase |
|---|---|---|
|
Head and Neck Cancer |
Biological: cetuximab Drug: cisplatin |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin Versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas |
Resource links provided by NLM:
Further study details as provided by National Cancer Institute (NCI):
Primary Outcome Measures:
- Disease-free survival (DFS) [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Overall survival (OS) [ Designated as safety issue: No ]
- Local-regional control (LRC) [ Designated as safety issue: No ]
- Mucositis toxicity ≥ grade 3 [ Designated as safety issue: Yes ]
- Other toxicity ≥ grade 3 [ Designated as safety issue: Yes ]
- Protocol treatment delivery [ Designated as safety issue: No ]
- Death ≤ 30 days after discontinuation of protocol treatment [ Designated as safety issue: Yes ]
- Quality of life as measured by Performance Status Scale for Head and Neck Cancer and the European Quality of Life questionnaire (EQ-5D) [ Designated as safety issue: No ]
- Quality of life as measured by Functional Assessment of Cancer Therapy-General version [ Designated as safety issue: No ]
- Correlation of expression of epidermal growth factor receptor or its down-stream molecules (e.g., MAPK, AKT, Stat-3, PKC) with DFS, OS, and LRC [ Designated as safety issue: No ]
- Correlation of pre-treatment positron emission tomography (PET)/CT scan findings with DFS, OS, and LRC [ Designated as safety issue: No ]
- Correlation of post-treatment PET/CT scan findings with pathologic nodal complete response and nodal relapse rate at 2 years in clinical N2-3 patients [ Designated as safety issue: No ]
| Estimated Enrollment: | 720 |
| Study Start Date: | November 2005 |
| Estimated Primary Completion Date: | June 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Arm I
Patients receive cisplatin IV over 1 hour on days 1 and 22 (weeks 1 and 4) during radiotherapy.
|
Drug: cisplatin
Given IV
|
|
Experimental: Arm II
Patients receive cetuximab IV over 1-2 hours once in weeks 0-7 and cisplatin as in arm I.
|
Biological: cetuximab
Given IV
Drug: cisplatin
Given IV
|
Detailed Description:
OBJECTIVES:
Primary
- Evaluate whether the addition of cetuximab to a concurrent radiation-cisplatin regimen will improve disease-free survival in patients with stage III or IV squamous cell carcinoma of the oropharynx, hypopharynx, or larynx.
Secondary
- Determine the impact of the addition of cetuximab to a concurrent radiation-cisplatin regimen on overall survival, local-regional control, acute and late toxic effects, quality of life, and health utilities in these patients.
- Correlate the expression of EGFR and its down-stream molecules with outcome in patients participating in this component of the trial.
- Correlate pre-treatment PET scan findings with disease-free survival, overall survival, and local-regional control in patients participating in this component of the trial.
- Correlate post-treatment PET scan findings with nodal response and nodal relapse in patients participating in this component of the trial.
OUTLINE: This is a randomized, controlled, multicenter study. Patients are stratified according to primary site (larynx vs non-larynx), nodal stage (N0 vs N1, N2a, N2b vs N2c, N3), Zubrod performance status (0 vs 1), use of intensity modulated radiotherapy (IMRT) (no vs yes), and pre-treatment PET/CT scan (no vs yes). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients undergo either 3D-conformal radiotherapy or IMRT once or twice a day, 5 or 6 days a week, for 6 weeks. Patients also receive cisplatin IV over 1 hour on days 1 and 22 (weeks 1 and 4) during radiotherapy.
- Arm II: Patients receive cetuximab IV over 1-2 hours once in weeks 0-7. Beginning in week 1, patients also undergo radiotherapy and receive cisplatin as in arm I.
In both arms, patients with persistent nodal disease (any stage) (i.e., a residual palpable or radiographic abnormality) undergo neck dissection* approximately 9-10 weeks after completion of treatment.
NOTE: *A neck dissection is optional for patients with multiple lymph nodes or lymph nodes > 3 cm in diameter who achieve a complete clinical and radiographic response in the neck.
Quality of life is assessed at baseline, once during the last 2 weeks of treatment, at 3 and 12 months from the start of treatment, and then annually for 4 years.
After completion of study treatment, patients are followed periodically for 5 years and then annually thereafter.
PROJECTED ACCRUAL: Approximately 720 patients will be accrued for this study.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS:
Histologically proven (from primary lesion and/or lymph nodes) squamous cell carcinoma of the oropharynx, hypopharynx, or larynx
Stage III or IV disease (T2, N2-3, M0; T3-4, any N, M0)
- No distant metastases
The following primary tumor sites are excluded:
- Oral cavity
- Nasopharynx
- Sinuses
- Salivary glands
PATIENT CHARACTERISTICS:
- Zubrod performance status 0-1
- Absolute neutrophil count (ANC) ≥ 1,800/mm^3
- Platelets ≥ 100,000/mm^3
- Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable)
- Bilirubin ≤ 1.5 mg/dL (Gilbert's disease as the sole cause of elevated bilirubin may be allowed at the discretion of the principal investigator)
- AST or ALT ≤ 2 times the upper limit of normal
- Serum creatinine ≤ 1.5 mg/dL
- Creatinine clearance ≥ 50 mL/min
- Not pregnant or nursing
- Negative pregnancy test
- Women of childbearing potential and male participants must agree to use a medically effective means of birth control throughout their participation in the treatment phase of the study (until at least 60 days following the last study treatment)
- No prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years
- No unstable angina and/or congestive heart failure requiring hospitalization in past 6 months
- Left ventricular ejection fraction ≥ 45%
- No transmural myocardial infarction within the last 6 months
- No acute bacterial or fungal infection requiring intravenous antibiotics
- No chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy
No acquired immune deficiency syndrome (AIDS)
- HIV testing is not required for entry into this protocol
- Protocol-specific requirements may also exclude immuno-compromised patients
- No prior allergic reaction to the study drug(s)
- No other uncontrolled condition, which in the opinion of the investigator, would interfere in the safe and timely completion of study procedures
- No comorbidity of uncontrolled diabetes (i.e., symptomatic hyperglycemia)
- No other severe active comorbidity
PRIOR CONCURRENT THERAPY:
No prior systemic chemotherapy for the study cancer
- Prior chemotherapy for a different cancer is allowed
- No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
- No initial surgical treatment (excluding diagnostic biopsy of the primary site or nodal sampling of neck disease)
- No radical or modified neck dissection
- No prior therapy that specifically and directly targets the EGFR pathway
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00265941
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| United States, Alabama | |
| Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham | |
| Birmingham, Alabama, United States, 35294 | |
| United States, Alaska | |
| Providence Cancer Center | |
| Anchorage, Alaska, United States, 99508 | |
| United States, Arizona | |
| Mayo Clinic Scottsdale | |
| Scottsdale, Arizona, United States, 85259-5499 | |
| United States, Arkansas | |
| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | |
| Little Rock, Arkansas, United States, 72205 | |
| United States, California | |
| Auburn Radiation Oncology | |
| Auburn, California, United States, 95603 | |
| Alta Bates Summit Comprehensive Cancer Center | |
| Berkeley, California, United States, 94704 | |
| Peninsula Medical Center | |
| Burlingame, California, United States, 94010 | |
| Radiation Oncology Centers - Cameron Park | |
| Cameron Park, California, United States, 95682 | |
| Mercy Cancer Center at Mercy San Juan Medical Center | |
| Carmichael, California, United States, 95608 | |
| East Bay Radiation Oncology Center | |
| Castro Valley, California, United States, 94546 | |
| Valley Medical Oncology Consultants - Castro Valley | |
| Castro Valley, California, United States, 94546 | |
| Cancer Care Center at John Muir Health - Concord Campus | |
| Concord, California, United States, 94524-4110 | |
| City of Hope Comprehensive Cancer Center | |
| Duarte, California, United States, 91010-3000 | |
| Valley Medical Oncology | |
| Fremont, California, United States, 94538 | |
| Virginia K. Crosson Cancer Center at St. Jude Medical Center | |
| Fullerton, California, United States, 92835 | |
| Sutter Health - Western Division Cancer Research Group | |
| Greenbrae, California, United States, 94904 | |
| Marin Cancer Institute at Marin General Hospital | |
| Greenbrae, California, United States, 94904 | |
| Rebecca and John Moores UCSD Cancer Center | |
| La Jolla, California, United States, 92093-0658 | |
| USC/Norris Comprehensive Cancer Center and Hospital | |
| Los Angeles, California, United States, 90089-9181 | |
| Memorial Medical Center | |
| Modesto, California, United States, 95355 | |
| CCOP - Bay Area Tumor Institute | |
| Oakland, California, United States, 94609 | |
| Larry G Strieff MD Medical Corporation | |
| Oakland, California, United States, 94609 | |
| Tom K Lee, Incorporated | |
| Oakland, California, United States, 94609 | |
| Alta Bates Summit Medical Center - Summit Campus | |
| Oakland, California, United States, 94609 | |
| Bay Area Breast Surgeons, Incorporated | |
| Oakland, California, United States, 94609 | |
| Valley Medical Oncology Consultants - Pleasanton | |
| Pleasanton, California, United States, 94588 | |
| Radiation Oncology Center - Roseville | |
| Roseville, California, United States, 95661 | |
| Radiological Associates of Sacramento Medical Group, Incorporated | |
| Sacramento, California, United States, 95815 | |
| Mercy General Hospital | |
| Sacramento, California, United States, 95819 | |
| University of California Davis Cancer Center | |
| Sacramento, California, United States, 95817 | |
| California Pacific Medical Center - California Campus | |
| San Francisco, California, United States, 94118 | |
| San Francisco General Hospital Medical Center | |
| San Francisco, California, United States, 94110 | |
| UCSF Helen Diller Family Comprehensive Cancer Center | |
| San Francisco, California, United States, 94115 | |
| Doctors Medical Center - San Pablo Campus | |
| San Pablo, California, United States, 94806 | |
| Stanford Cancer Center | |
| Stanford, California, United States, 94305-5824 | |
| General Robert Huyser Cancer Center at David Grant Medical Center | |
| Travis AFB, California, United States, 94535-1800 | |
| Solano Radiation Oncology Center | |
| Vacaville, California, United States, 95687 | |
| Sutter Solano Medical Center | |
| Vallejo, California, United States, 94589 | |
| John Muir/Mt. Diablo Comprehensive Cancer Center | |
| Walnut Creek, California, United States, 94598 | |
| United States, Colorado | |
| Aurora Presbyterian Hospital | |
| Aurora, Colorado, United States, 80012 | |
| University of Colorado Cancer Center at UC Health Sciences Center | |
| Aurora, Colorado, United States, 80045 | |
| Boulder Community Hospital | |
| Boulder, Colorado, United States, 80301-9019 | |
| Penrose Cancer Center at Penrose Hospital | |
| Colorado Springs, Colorado, United States, 80933 | |
| St. Joseph Hospital | |
| Denver, Colorado, United States, 80218 | |
| Veterans Affairs Medical Center - Denver | |
| Denver, Colorado, United States, 80220 | |
| Presbyterian - St. Luke's Medical Center | |
| Denver, Colorado, United States, 80218 | |
| Porter Adventist Hospital | |
| Denver, Colorado, United States, 80210 | |
| Swedish Medical Center | |
| Englewood, Colorado, United States, 80110 | |
| Poudre Valley Radiation Oncology | |
| Fort Collins, Colorado, United States, 80528 | |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | |
| Grand Junction, Colorado, United States, 81502 | |
| North Colorado Medical Center | |
| Greeley, Colorado, United States, 80631 | |
| Sky Ridge Medical Center | |
| Lone Tree, Colorado, United States, 80124 | |
| Hope Cancer Care Center at Longmont United Hospital | |
| Longmont, Colorado, United States, 80502 | |
| McKee Medical Center | |
| Loveland, Colorado, United States, 80539 | |
| St. Mary - Corwin Regional Medical Center | |
| Pueblo, Colorado, United States, 81004 | |
| North Suburban Medical Center | |
| Thornton, Colorado, United States, 80229 | |
| Exempla Lutheran Medical Center | |
| Wheat Ridge, Colorado, United States, 80033 | |
| United States, Delaware | |
| CCOP - Christiana Care Health Services | |
| Newark, Delaware, United States, 19713 | |
| United States, District of Columbia | |
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | |
| Washington, District of Columbia, United States, 20007 | |
| Washington Cancer Institute at Washington Hospital Center | |
| Washington, District of Columbia, United States, 20010 | |
| United States, Florida | |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | |
| Fort Lauderdale, Florida, United States, 33308 | |
| Memorial Cancer Institute at Memorial Regional Hospital | |
| Hollywood, Florida, United States, 33021 | |
| Baptist Cancer Institute - Jacksonville | |
| Jacksonville, Florida, United States, 32207 | |
| Integrated Community Oncology Network at Southside Cancer Center | |
| Jacksonville, Florida, United States, 32207 | |
| Mayo Clinic - Jacksonville | |
| Jacksonville, Florida, United States, 32224 | |
| Integrated Community Oncology Network | |
| Jacksonville Beach, Florida, United States, 32250 | |
| Baptist Medical Center South | |
| Jascksonville, Florida, United States, 32258 | |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | |
| Jupiter, Florida, United States, 33458 | |
| University of Miami Sylvester Comprehensive Cancer Center - Miami | |
| Miami, Florida, United States, 33136 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| Integrated Community Oncology Network - Orange Park | |
| Orange Park, Florida, United States, 32073 | |
| M.D. Anderson Cancer Center at Orlando | |
| Orlando, Florida, United States, 32806 | |
| Florida Cancer Center - Palatka | |
| Palatka, Florida, United States, 32177 | |
| Bay Medical | |
| Panama City, Florida, United States, 32401 | |
| Flagler Cancer Center | |
| Saint Augustine, Florida, United States, 32086 | |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | |
| Tampa, Florida, United States, 33612-9497 | |
| United States, Georgia | |
| Winship Cancer Institute of Emory University | |
| Altanta, Georgia, United States, 30322 | |
| CCOP - Atlanta Regional | |
| Atlanta, Georgia, United States, 30342 | |
| Emory Crawford Long Hospital | |
| Atlanta, Georgia, United States, 30308 | |
| Georgia Cancer Center for Excellence at Grady Memorial Hospital | |
| Atlanta, Georgia, United States, 30303 | |
| Saint Joseph's Hospital of Atlanta | |
| Atlanta, Georgia, United States, 30342-1701 | |
| Northside Hospital Cancer Center | |
| Atlanta, Georgia, United States, 30342-1611 | |
| Piedmont Hospital | |
| Atlanta, Georgia, United States, 30309 | |
| Charles B. Eberhart Cancer Center at DeKalb Medical Center | |
| Decatur, Georgia, United States, 30033 | |
| Veterans Affairs Medical Center - Atlanta (Decatur) | |
| Decatur, Georgia, United States, 30033 | |
| Northeast Georgia Medical Center | |
| Gainesville, Georgia, United States, 30501 | |
| Medical Center of Central Georgia | |
| Macon, Georgia, United States, 31208 | |
| Kennestone Cancer Center at Wellstar Kennestone Hospital | |
| Marietta, Georgia, United States, 30060 | |
| Southern Regional Medical Center | |
| Riverdale, Georgia, United States, 30274-2600 | |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | |
| Savannah, Georgia, United States, 31405 | |
| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | |
| Savannah, Georgia, United States, 31403-3089 | |
| United States, Idaho | |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | |
| Boise, Idaho, United States, 83712 | |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |
| Boise, Idaho, United States, 83706 | |
| United States, Illinois | |
| Saint Anthony's Hospital at Saint Anthony's Health Center | |
| Alton, Illinois, United States, 62002 | |
| Rush-Copley Cancer Care Center | |
| Aurora, Illinois, United States, 60504 | |
| Good Shepherd Hospital | |
| Barrington, Illinois, United States, 60010 | |
| St. Joseph Medical Center | |
| Bloomington, Illinois, United States, 61701 | |
| University of Illinois Cancer Center | |
| Chicago, Illinois, United States, 60612-7243 | |
| John H. Stroger, Jr. Hospital of Cook County | |
| Chicago, Illinois, United States, 60612-3785 | |
| Rush University Medical Center | |
| Chicago, Illinois, United States, 60612 | |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | |
| Chicago, Illinois, United States, 60657 | |
| Decatur Memorial Hospital Cancer Care Institute | |
| Decatur, Illinois, United States, 62526 | |
| Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital | |
| Downers Grove, Illinois, United States, 60515-1500 | |
| InterCommunity Cancer Center of Western Illinois | |
| Galesburg, Illinois, United States, 61401 | |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | |
| Harvey, Illinois, United States, 60426 | |
| Joliet Oncology-Hematology Associates, Limited - West | |
| Joliet, Illinois, United States, 60435 | |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |
| Maywood, Illinois, United States, 60153 | |
| Community Cancer Center | |
| Normal, Illinois, United States, 61761 | |
| BroMenn Regional Medical Center | |
| Normal, Illinois, United States, 61761 | |
| Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields | |
| Olympia Fields, Illinois, United States, 60461 | |
| Advocate Lutheran General Cancer Care Center | |
| Park Ridge, Illinois, United States, 60068-1174 | |
| Cancer Treatment Center at Pekin Hospital | |
| Pekin, Illinois, United States, 61554 | |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | |
| Peoria, Illinois, United States, 61615 | |
| OSF St. Francis Medical Center | |
| Peoria, Illinois, United States, 61615-7827 | |
| CCOP - Illinois Oncology Research Association | |
| Peoria, Illinois, United States, 61615 | |
| Methodist Medical Center of Illinois | |
| Peoria, Illinois, United States, 61636 | |
| Swedish-American Regional Cancer Center | |
| Rockford, Illinois, United States, 61104-2315 | |
| Center for Cancer Care at OSF Saint Anthony Medical Center | |
| Rockford, Illinois, United States, 61108 | |
| Valley Cancer Center | |
| Spring Valley, Illinois, United States, 61362 | |
| Cancer Institute at St. John's Hospital | |
| Springfield, Illinois, United States, 62702 | |
| Carle Cancer Center at Carle Foundation Hospital | |
| Urbana, Illinois, United States, 61801 | |
| CCOP - Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| Saint John's Cancer Center at Saint John's Medical Center | |
| Anderson, Indiana, United States, 46016 | |
| St. Francis Hospital and Health Centers - Beech Grove Campus | |
| Beech Grove, Indiana, United States, 46107 | |
| Elkhart General Hospital | |
| Elkhart, Indiana, United States, 46515 | |
| Parkview Regional Cancer Center at Parkview Health | |
| Fort Wayne, Indiana, United States, 46805 | |
| Radiation Oncology Associates Southwest | |
| Fort Wayne, Indiana, United States, 46804 | |
| Center for Cancer Care at Goshen General Hospital | |
| Goshen, Indiana, United States, 46526 | |
| Methodist Cancer Center at Methodist Hospital | |
| Indianapolis, Indiana, United States, 46202 | |
| Howard Community Hospital | |
| Kokomo, Indiana, United States, 46904 | |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | |
| La Porte, Indiana, United States, 46350 | |
| Saint Anthony Memorial Health Centers | |
| Michigan City, Indiana, United States, 46360 | |
| Reid Hospital & Health Care Services | |
| Richmond, Indiana, United States, 47374 | |
| Memorial Hospital of South Bend | |
| South Bend, Indiana, United States, 46601 | |
| CCOP - Northern Indiana CR Consortium | |
| South Bend, Indiana, United States, 46601 | |
| United States, Iowa | |
| McFarland Clinic, PC | |
| Ames, Iowa, United States, 50010 | |
| Siouxland Hematology-Oncology Associates, LLP | |
| Sioux City, Iowa, United States, 51101 | |
| United States, Kansas | |
| Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | |
| Kansas City, Kansas, United States, 66160-7357 | |
| Menorah Medical Center | |
| Overland Park, Kansas, United States, 66209 | |
| Shawnee Mission Medical Center | |
| Shawnee Mission, Kansas, United States, 66204 | |
| Cotton-O'Neil Cancer Center | |
| Topeka, Kansas, United States, 66606 | |
| United States, Kentucky | |
| Lucille P. Markey Cancer Center at University of Kentucky | |
| Lexington, Kentucky, United States, 40536-0093 | |
| James Graham Brown Cancer Center at University of Louisville | |
| Louisville, Kentucky, United States, 40292 | |
| United States, Louisiana | |
| Tulane Cancer Center Office of Clinical Research | |
| Alexandria, Louisiana, United States, 71315-3198 | |
| Mary Bird Perkins Cancer Center - Baton Rouge | |
| Baton Rouge, Louisiana, United States, 70809 | |
| Pennington Cancer Center at Baton Rouge General | |
| Baton Rouge, Louisiana, United States, 70806 | |
| Medical Center of Louisiana - New Orleans | |
| New Orleans, Louisiana, United States, 70112 | |
| MBCCOP - LSU Health Sciences Center | |
| New Orleans, Louisiana, United States, 70112 | |
| Feist-Weiller Cancer Center at Louisiana State University Health Sciences | |
| Shreveport, Louisiana, United States, 71130-3932 | |
| United States, Maryland | |
| St. Agnes Hospital Cancer Center | |
| Baltimore, Maryland, United States, 21229 | |
| United States, Massachusetts | |
| Boston University Cancer Research Center | |
| Boston, Massachusetts, United States, 02118 | |
| Tufts-NEMC Cancer Center | |
| Boston, Massachusetts, United States, 02111 | |
| Lahey Clinic Medical Center - Burlington | |
| Burlington, Massachusetts, United States, 01805 | |
| NSMC Cancer Center - Peabody | |
| Peabody, Massachusetts, United States, 01960 | |
| United States, Michigan | |
| Saint Joseph Mercy Cancer Center | |
| Ann Arbor, Michigan, United States, 48106-0995 | |
| CCOP - Michigan Cancer Research Consortium | |
| Ann Arbor, Michigan, United States, 48106 | |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |
| Dearborn, Michigan, United States, 48123-2500 | |
| Barbara Ann Karmanos Cancer Institute | |
| Detroit, Michigan, United States, 48201-1379 | |
| Josephine Ford Cancer Center at Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Green Bay Oncology, Limited - Escanaba | |
| Escanaba, Michigan, United States, 49431 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| Genesys Hurley Cancer Institute | |
| Flint, Michigan, United States, 48503 | |
| Great Lakes Cancer Institute at McLaren Regional Medical Center | |
| Flint, Michigan, United States, 48532 | |
| CCOP - Grand Rapids | |
| Grand Rapids, Michigan, United States, 49503 | |
| Lacks Cancer Center at Saint Mary's Health Care | |
| Grand Rapids, Michigan, United States, 49503 | |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | |
| Grosse Pointe Woods, Michigan, United States, 48236 | |
| Dickinson County Healthcare System | |
| Iron Mountain, Michigan, United States, 49801 | |
| Foote Memorial Hospital | |
| Jackson, Michigan, United States, 49201 | |
| West Michigan Cancer Center | |
| Kalamazoo, Michigan, United States, 49007-3731 | |
| Bronson Methodist Hospital | |
| Kalamazoo, Michigan, United States, 49007 | |
| Borgess Medical Center | |
| Kalamazoo, Michigan, United States, 49001 | |
| Sparrow Regional Cancer Center | |
| Lansing, Michigan, United States, 48912-1811 | |
| St. Mary Mercy Hospital | |
| Livonia, Michigan, United States, 48154 | |
| Mercy Regional Cancer Center at Mercy Hospital | |
| Port Huron, Michigan, United States, 48060 | |
| William Beaumont Hospital - Royal Oak Campus | |
| Royal Oak, Michigan, United States, 48073 | |
| Seton Cancer Institute at Saint Mary's - Saginaw | |
| Saginaw, Michigan, United States, 48601 | |
| Providence Cancer Institute at Providence Hospital - Southfield Campus | |
| Southfield, Michigan, United States, 48075 | |
| Lakeland Regional Cancer Care Center - St. Joseph | |
| St. Joseph, Michigan, United States, 49085 | |
| Munson Medical Center | |
| Traverse City, Michigan, United States, 49684 | |
| St. John Macomb Hospital | |
| Warren, Michigan, United States, 48093 | |
| United States, Minnesota | |
| MeritCare Bemidji | |
| Bemidji, Minnesota, United States, 56601 | |
| Fairview Ridges Hospital | |
| Burnsville, Minnesota, United States, 55337 | |
| Mercy and Unity Cancer Center at Mercy Hospital | |
| Coon Rapids, Minnesota, United States, 55433 | |
| St. Luke's Hospital Cancer Care Center | |
| Duluth, Minnesota, United States, 55805 | |
| CCOP - Duluth | |
| Duluth, Minnesota, United States, 55805 | |
| Duluth Clinic Cancer Center - Duluth | |
| Duluth, Minnesota, United States, 55805-1983 | |
| Miller - Dwan Medical Center | |
| Duluth, Minnesota, United States, 55805 | |
| Fairview Southdale Hospital | |
| Edina, Minnesota, United States, 55435 | |
| Mercy and Unity Cancer Center at Unity Hospital | |
| Fridley, Minnesota, United States, 55432 | |
| Minnesota Oncology Hematology, PA - Maplewood | |
| Maplewood, Minnesota, United States, 55109 | |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |
| Minneapolis, Minnesota, United States, 55407 | |
| Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | |
| Robbinsdale, Minnesota, United States, 55422-2900 | |
| Mayo Clinic Cancer Center | |
| Rochester, Minnesota, United States, 55905 | |
| Park Nicollet Cancer Center | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| CCOP - Metro-Minnesota | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United Hospital | |
| Saint Paul, Minnesota, United States, 55102 | |
| St. Francis Cancer Center at St. Francis Medical Center | |
| Shakopee, Minnesota, United States, 55379 | |
| Ridgeview Medical Center | |
| Waconia, Minnesota, United States, 55387 | |
| United States, Mississippi | |
| University of Mississippi Cancer Clinic | |
| Jackson, Mississippi, United States, 39216 | |
| Regional Cancer Center at Singing River Hospital | |
| Pascagoula, Mississippi, United States, 39581 | |
| United States, Missouri | |
| Cancer Institute of Cape Girardeau, LLC | |
| Cape Girardeau, Missouri, United States, 63703 | |
| Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital | |
| Cape Girardeau, Missouri, United States, 63701 | |
| Saint Francis Medical Center | |
| Cape Girardeau, Missouri, United States, 63703 | |
| Independence Regional Health Center | |
| Independence, Missouri, United States, 64050 | |
| St. Joseph Medical Center | |
| Kansas City, Missouri, United States, 64114 | |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | |
| Kansas City, Missouri, United States, 64111 | |
| Truman Medical Center - Hospital Hill | |
| Kansas City, Missouri, United States, 64108 | |
| Parvin Radiation Oncology | |
| Kansas City, Missouri, United States, 64116 | |
| North Kansas City Hospital | |
| Kansas City, Missouri, United States, 64116 | |
| CCOP - Kansas City | |
| Kansas City, Missouri, United States, 64131 | |
| Research Medical Center | |
| Kansas City, Missouri, United States, 64132 | |
| Liberty Hospital | |
| Liberty, Missouri, United States, 64068 | |
| Heartland Regional Medical Center | |
| Saint Joseph, Missouri, United States, 64506 | |
| David C. Pratt Cancer Center at St. John's Mercy | |
| Saint Louis, Missouri, United States, 63141 | |
| CCOP - St. Louis-Cape Girardeau | |
| Saint Louis, Missouri, United States, 63141 | |
| Saint Louis University Cancer Center | |
| Saint Louis, Missouri, United States, 63110 | |
| St. John's Regional Health Center | |
| Springfield, Missouri, United States, 65804 | |
| Hulston Cancer Center at Cox Medical Center South | |
| Springfield, Missouri, United States, 65807 | |
| CCOP - Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65802 | |
| United States, Montana | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| Billings Clinic - Downtown | |
| Billings, Montana, United States, 59107-7000 | |
| Northern Rockies Radiation Oncology Center | |
| Billings, Montana, United States, 59101 | |
| Great Falls, Montana, United States, 59405 | |
| Great Falls Clinic - Main Facility | |
| Great Falls, Montana, United States, 59405 | |
| United States, Nebraska | |
| Good Samaritan Cancer Center at Good Samaritan Hospital | |
| Kearney, Nebraska, United States, 68848-1990 | |
| CCOP - Missouri Valley Cancer Consortium | |
| Omaha, Nebraska, United States, 68106 | |
| Creighton University Medical Center | |
| Omaha, Nebraska, United States, 68131-2197 | |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | |
| Omaha, Nebraska, United States, 68124 | |
| Immanuel Medical Center | |
| Omaha, Nebraska, United States, 68122 | |
| Methodist Estabrook Cancer Center | |
| Omaha, Nebraska, United States, 68114 | |
| United States, Nevada | |
| CCOP - Nevada Cancer Research Foundation | |
| Las Vegas, Nevada, United States, 89106 | |
| United States, New Hampshire | |
| Dartmouth - Hitchcock Concord | |
| Concord, New Hampshire, United States, 03301 | |
| Kingsbury Center for Cancer Care at Cheshire Medical Center | |
| Keene, New Hampshire, United States, 03431 | |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | |
| Lebanon, New Hampshire, United States, 03756-0002 | |
| Elliot Regional Cancer Center at Elliot Hospital | |
| Manchester, New Hampshire, United States, 03103 | |
| United States, New Jersey | |
| Ocean Medical Center at Meridian Health | |
| Brick, New Jersey, United States, 08724 | |
| Princeton Radiation Oncology Center | |
| Jamesburg, New Jersey, United States, 08831 | |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | |
| New Brunswick, New Jersey, United States, 08903 | |
| Saint Peter's University Hospital | |
| New Brunswick, New Jersey, United States, 08901 | |
| University Medical Center at Princeton | |
| Princeton, New Jersey, United States, 08540-3298 | |
| Frederick R. and Betty M. Smith Cancer Treatment Center | |
| Sparta, New Jersey, United States, 07871 | |
| J. Phillip Citta Regional Cancer Center at Community Medical Center | |
| Toms River, New Jersey, United States, 08755 | |
| Cancer Institute of New Jersey at Cooper - Voorhees | |
| Voorhees, New Jersey, United States, 08043 | |
| United States, New Mexico | |
| New Mexico Cancer Center | |
| Albuquerque, New Mexico, United States, 87109 | |
| United States, New York | |
| Maimonides Cancer Center at Maimonides Medical Center | |
| Brooklyn, New York, United States, 11219 | |
| Roswell Park Cancer Institute | |
| Buffalo, New York, United States, 14263-0001 | |
| CCOP - Hematology-Oncology Associates of Central New York | |
| East Syracuse, New York, United States, 13057 | |
| Charles R. Wood Cancer Center at Glens Falls Hospital | |
| Glens Falls, New York, United States, 12801 | |
| St. Vincent's Comprehensive Cancer Center - Manhattan | |
| New York, New York, United States, 10011 | |
| Highland Hospital of Rochester | |
| Rochester, New York, United States, 14620 | |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | |
| Rochester, New York, United States, 14642 | |
| United States, North Carolina | |
| Mission Hospitals - Memorial Campus | |
| Asheville, North Carolina, United States, 28801 | |
| Presbyterian Cancer Center at Presbyterian Hospital | |
| Charlotte, North Carolina, United States, 28233-3549 | |
| Wayne Radiation Oncology | |
| Goldsboro, North Carolina, United States, 27534 | |
| Wayne Memorial Hospital, Incorporated | |
| Goldsboro, North Carolina, United States, 27534 | |
| Leo W. Jenkins Cancer Center at ECU Medical School | |
| Greenville, North Carolina, United States, 27834 | |
| Pardee Memorial Hospital | |
| Hendersonville, North Carolina, United States, 28791 | |
| Cancer Centers of North Carolina - Raleigh | |
| Raleigh, North Carolina, United States, 27607 | |
| Rex Cancer Center at Rex Hospital | |
| Raleigh, North Carolina, United States, 27607 | |
| Wilmed Radiation Oncology Services | |
| Wilson, North Carolina, United States, 27893 | |
| Forsyth Regional Cancer Center at Forsyth Medical Center | |
| Winston-Salem, North Carolina, United States, 27103 | |
| United States, North Dakota | |
| CCOP - MeritCare Hospital | |
| Fargo, North Dakota, United States, 58122 | |
| MeritCare Broadway | |
| Fargo, North Dakota, United States, 58122 | |
| United States, Ohio | |
| Summa Center for Cancer Care at Akron City Hospital | |
| Akron, Ohio, United States, 44309-2090 | |
| McDowell Cancer Center at Akron General Medical Center | |
| Akron, Ohio, United States, 44307 | |
| Adena Regional Medical Center | |
| Chillicothe, Ohio, United States, 45601 | |
| Charles M. Barrett Cancer Center at University Hospital | |
| Cincinnati, Ohio, United States, 45267 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43215 | |
| Grant Medical Center Cancer Care | |
| Columbus, Ohio, United States, 43215 | |
| Doctors Hospital at Ohio Health | |
| Columbus, Ohio, United States, 43228 | |
| Mount Carmel Health - West Hospital | |
| Columbus, Ohio, United States, 43222 | |
| Riverside Methodist Hospital Cancer Care | |
| Columbus, Ohio, United States, 43214-3998 | |
| David L. Rike Cancer Center at Miami Valley Hospital | |
| Dayton, Ohio, United States, 45409 | |
| CCOP - Dayton | |
| Dayton, Ohio, United States, 45429 | |
| Grandview Hospital | |
| Dayton, Ohio, United States, 45405 | |
| Good Samaritan Hospital | |
| Dayton, Ohio, United States, 45406 | |
| Samaritan North Cancer Care Center | |
| Dayton, Ohio, United States, 45415 | |
| Veterans Affairs Medical Center - Dayton | |
| Dayton, Ohio, United States, 45428 | |
| Grady Memorial Hospital | |
| Delaware, Ohio, United States, 43015 | |
| Blanchard Valley Medical Associates | |
| Findlay, Ohio, United States, 45840 | |
| Middletown Regional Hospital | |
| Franklin, Ohio, United States, 45005-1066 | |
| Charles F. Kettering Memorial Hospital | |
| Kettering, Ohio, United States, 45429 | |
| St. Rita's Medical Center | |
| Lima, Ohio, United States, 45801 | |
| Strecker Cancer Center at Marietta Memorial Hospital | |
| Marietta, Ohio, United States, 45750 | |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | |
| Newark, Ohio, United States, 43055 | |
| Mercy Medical Center | |
| Springfield, Ohio, United States, 45504 | |
| UVMC Cancer Care Center at Upper Valley Medical Center | |
| Troy, Ohio, United States, 45373-1300 | |
| Precision Radiotherapy at University Pointe | |
| West Chester, Ohio, United States, 45069 | |
| Mount Carmel St. Ann's Cancer Center | |
| Westerville, Ohio, United States, 43081 | |
| Cancer Treatment Center | |
| Wooster, Ohio, United States, 44691 | |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |
| Xenia, Ohio, United States, 45385 | |
| United States, Oklahoma | |
| Oklahoma University Cancer Institute | |
| Oklahoma City, Oklahoma, United States, 73104 | |
| United States, Oregon | |
| Bay Area Hospital | |
| Coos Bay, Oregon, United States, 97420 | |
| Three Rivers Community Hospital | |
| Grants Pass, Oregon, United States, 97527 | |
| Legacy Mount Hood Medical Center | |
| Gresham, Oregon, United States, 97030 | |
| Dubs Cancer Center at Rogue Valley Medical Center | |
| Medford, Oregon, United States, 97504 | |
| Providence Cancer Center at PMCC | |
| Medford, Oregon, United States, 97504 | |
| Providence Milwaukie Hospital | |
| Milwaukie, Oregon, United States, 97222 | |
| CCOP - Columbia River Oncology Program | |
| Portland, Oregon, United States, 97225 | |
| Providence Cancer Center at Providence Portland Medical Center | |
| Portland, Oregon, United States, 97213-2967 | |
| Legacy Emanuel Hospital and Health Center and Children's Hospital | |
| Portland, Oregon, United States, 97227 | |
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | |
| Portland, Oregon, United States, 97210 | |
| Adventist Medical Center | |
| Portland, Oregon, United States, 97216 | |
| Oregon Health and Science University Cancer Institute | |
| Portland, Oregon, United States, 97239-3098 | |
| Providence St. Vincent Medical Center | |
| Portland, Oregon, United States, 97225 | |
| Legacy Meridian Park Hospital | |
| Tualatin, Oregon, United States, 97062 | |
| United States, Pennsylvania | |
| Geisinger Cancer Institute at Geisinger Health | |
| Danville, Pennsylvania, United States, 17822-0001 | |
| Mercy Fitzgerald Hospital | |
| Darby, Pennsylvania, United States, 19023 | |
| Northeast Radiation Oncology Center | |
| Dunmore, Pennsylvania, United States, 18512 | |
| Dale and Frances Hughes Cancer Center at Pocono Medical Center | |
| East Stroudsburg, Pennsylvania, United States, 18301 | |
| Upper Delaware Valley Cancer Center | |
| Milford, Pennsylvania, United States, 18337 | |
| Albert Einstein Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19141 | |
| Fox Chase Cancer Center - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19111-2497 | |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19107-5541 | |
| McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center | |
| Reading, Pennsylvania, United States, 19612-6052 | |
| St. Joseph Medical Center | |
| Reading, Pennsylvania, United States, 19604 | |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | |
| Wilkes-Barre, Pennsylvania, United States, 18711 | |
| York Cancer Center at Apple Hill Medical Center | |
| York, Pennsylvania, United States, 17405 | |
| United States, Rhode Island | |
| Miriam Hospital | |
| Providence, Rhode Island, United States, 02906 | |
| Rhode Island Hospital Comprehensive Cancer Center | |
| Providence, Rhode Island, United States, 02903 | |
| United States, South Carolina | |
| Hollings Cancer Center at Medical University of South Carolina | |
| Charleston, South Carolina, United States, 29425 | |
| CCOP - Greenville | |
| Greenville, South Carolina, United States, 29615 | |
| United States, South Dakota | |
| Rapid City Regional Hospital | |
| Rapid City, South Dakota, United States, 57701 | |
| Sanford Cancer Center at Sanford USD Medical Center | |
| Sioux Falls, South Dakota, United States, 57117-5039 | |
| United States, Texas | |
| Harrington Cancer Center | |
| Amarillo, Texas, United States, 79106 | |
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | |
| Dallas, Texas, United States, 75390 | |
| Brooke Army Medical Center | |
| Fort Sam Houston, Texas, United States, 78234-6200 | |
| M. D. Anderson Cancer Center at University of Texas | |
| Houston, Texas, United States, 77030-4009 | |
| Wilford Hall Medical Center | |
| Lackland AFB, Texas, United States, 78236 | |
| Joe Arrington Cancer Research and Treatment Center | |
| Lubbock, Texas, United States, 79410-1894 | |
| United States, Utah | |
| Sandra L. Maxwell Cancer Center | |
| Cedar City, Utah, United States, 84720 | |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | |
| Murray, Utah, United States, 84157 | |
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | |
| Ogden, Utah, United States, 84403 | |
| Utah Valley Regional Medical Center - Provo | |
| Provo, Utah, United States, 84604 | |
| Dixie Regional Medical Center - East Campus | |
| Saint George, Utah, United States, 84770 | |
| Utah Cancer Specialists at UCS Cancer Center | |
| Salt Lake City, Utah, United States, 84106 | |
| Huntsman Cancer Institute at University of Utah | |
| Salt Lake City, Utah, United States, 84112 | |
| LDS Hospital | |
| Salt Lake City, Utah, United States, 84143 | |
| United States, Vermont | |
| Norris Cotton Cancer Center - North | |
| Saint Johnsbury, Vermont, United States, 05819 | |
| United States, Virginia | |
| INOVA Alexandria Hospital | |
| Alexandria, Virginia, United States, 22304 | |
| Danville Regional Medical Center | |
| Danville, Virginia, United States, 24541 | |
| Lynchburg Hematology-Oncology Clinic | |
| Lynchburg, Virginia, United States, 24501 | |
| Sentara Cancer Institute at Sentara Norfolk General Hospital | |
| Norfolk, Virginia, United States, 23507 | |
| Naval Medical Center - Portsmouth | |
| Portsmouth, Virginia, United States, 23708-2197 | |
| Veterans Affairs Medical Center - Richmond | |
| Richmond, Virginia, United States, 23249 | |
| Virginia Commonwealth University Massey Cancer Center | |
| Richmond, Virginia, United States, 23298-0037 | |
| United States, Washington | |
| St. Francis Hospital | |
| Federal Way, Washington, United States, 98003 | |
| Southwest Washington Medical Center Cancer Center | |
| Vancouver, Washington, United States, 98668 | |
| United States, Wisconsin | |
| Theda Care Cancer Institute | |
| Appleton, Wisconsin, United States, 54911 | |
| Green Bay Oncology, Limited at St. Mary's Hospital | |
| Green Bay, Wisconsin, United States, 54303 | |
| St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54307-3508 | |
| St. Mary's Hospital Medical Center - Green Bay | |
| Green Bay, Wisconsin, United States, 54303 | |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54301-3526 | |
| Gundersen Lutheran Center for Cancer and Blood | |
| La Crosse, Wisconsin, United States, 54601 | |
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |
| Madison, Wisconsin, United States, 53792-6164 | |
| Bay Area Cancer Care Center at Bay Area Medical Center | |
| Marinette, Wisconsin, United States, 54143 | |
| Columbia Saint Mary's Hospital - Ozaukee | |
| Mequon, Wisconsin, United States, 53097 | |
| Medical College of Wisconsin Cancer Center | |
| Milwaukee, Wisconsin, United States, 53226 | |
| Columbia-Saint Mary's Cancer Care Center | |
| Milwaukee, Wisconsin, United States, 53211 | |
| Veterans Affairs Medical Center - Milwaukee | |
| Milwaukee, Wisconsin, United States, 53295 | |
| Green Bay Oncology, Limited - Oconto Falls | |
| Oconto Falls, Wisconsin, United States, 54154 | |
| Green Bay Oncology, Limited - Sturgeon Bay | |
| Sturgeon Bay, Wisconsin, United States, 54235 | |
| University of Wisconcin Cancer Center at Aspirus Wausau Hospital | |
| Wausau, Wisconsin, United States, 54401 | |
| Canada, Alberta | |
| Tom Baker Cancer Centre - Calgary | |
| Calgary, Alberta, Canada, T2N 4N2 | |
| Canada, Manitoba | |
| CancerCare Manitoba | |
| Winnipeg, Manitoba, Canada, R3E 0V9 | |
| Canada, Nova Scotia | |
| Nova Scotia Cancer Centre | |
| Halifax, Nova Scotia, Canada, B3H 1V8 | |
| Canada, Ontario | |
| Ottawa Hospital Regional Cancer Centre - General Campus | |
| Ottawa, Ontario, Canada, K1Y 4K7 | |
| Northeastern Ontario Regional Cancer Centre | |
| Sudbury, Ontario, Canada, P3E 5J1 | |
| Princess Margaret Hospital | |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Canada, Quebec | |
| Hopital Notre-Dame du CHUM | |
| Montreal, Quebec, Canada, H2L 4M1 | |
| McGill Cancer Centre at McGill University | |
| Montreal, Quebec, Canada, H2W 1S6 | |
| Canada, Saskatchewan | |
| Allan Blair Cancer Centre at Pasqua Hospital | |
| Regina, Saskatchewan, Canada, S4T 7T1 | |
Sponsors and Collaborators
Radiation Therapy Oncology Group
Investigators
| Principal Investigator: | K. Kian Ang, MD, PhD | M.D. Anderson Cancer Center |
More Information
Additional Information:
Publications:
Ang K, Zhang Q, Rosenthal DI, et al.: A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC). [Abstract] J Clin Oncol 29 (Suppl 15): A-5500, 2011.
| Responsible Party: | Walter John Curran, Jr, Radiation Therapy Oncology Group |
| ClinicalTrials.gov Identifier: | NCT00265941 History of Changes |
| Other Study ID Numbers: | CDR0000458049, RTOG-0522 |
| Study First Received: | December 14, 2005 |
| Last Updated: | September 8, 2011 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by National Cancer Institute (NCI):
|
stage III squamous cell carcinoma of the hypopharynx stage IV squamous cell carcinoma of the hypopharynx stage III squamous cell carcinoma of the larynx |
stage IV squamous cell carcinoma of the larynx stage III squamous cell carcinoma of the oropharynx stage IV squamous cell carcinoma of the oropharynx |
Additional relevant MeSH terms:
|
Head and Neck Neoplasms Neoplasms by Site Neoplasms Cetuximab Cisplatin |
Antineoplastic Agents Therapeutic Uses Pharmacologic Actions Radiation-Sensitizing Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 19, 2013