JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events

This study has been terminated.
(See detailed description for reason.)
Sponsor:
Information provided by (Responsible Party):
AstraZeneca
ClinicalTrials.gov Identifier:
NCT00239681
First received: October 13, 2005
Last updated: February 6, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to determine the safety and effectiveness of long-term therapy with rosuvastatin compared with a placebo, and to evaluate whether treatment with rosuvastatin might be effective in reducing the risk of major cardiovascular events.


Condition Intervention Phase
Elevated High-sensitivity C-Reactive Protein (hsCRP)
Drug: Rosuvastatin
Other: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: A Randomized, Double-Blind, Placebo Controlled, Multicenter, Phase 3 Study of Rosuvastatin (CRESTOR®) 20 mg in the Prevention of Cardiovascular Events Among Subjects With Low Levels of Low Density Lipoprotein(LDL) Cholesterol & Elevated Levels of C-Reactive Protein

Resource links provided by NLM:


Further study details as provided by AstraZeneca:

Primary Outcome Measures:
  • Time to Major Cardiac Event (Cardiovascular Death, Stroke, Myocardial Infarction, Hospitalization Due to Unstable Angina or Arterial Revascularization) [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]
    Days from randomization to the first of CV death, stroke, MI, hospitalization for unstable angina or arterial revascularization. If no event, censoring occurs at earliest of termination date or efficacy cut-off date of 30 Mar 2008. Events were adjudicated by an endpoint committee. Kaplan-Meier estimate of the mean


Secondary Outcome Measures:
  • Time to Death Due to Any Cause [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]
    Days from randomization to death. If no death then censoring occurs at earliest of termination date or efficacy cutoff date of 30 Mar 2008. Kaplan-Meier estimate of the mean

  • Time to Non-cardiovascular Death [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]
    Days from randomization to death from a non-cardiovascular cause. If no event, then censoring occurs at earliest of termination date or efficacy cutoff date of 30 Mar 2008. Events were adjudicated by an endpoint committee. Kaplan-Meier estimate of the mean

  • Time to Development of Diabetes Mellitus [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]
    Days from randomization until development of diabetes. If no diabetes was developed censoring occurred at termination date. Kaplan-Meier estimate of the mean

  • Time to Venous Thromboembolic Event [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]
    Time from randomization to the first venous thromboembolic event. Kaplan-Meier estimate of the mean

  • Time to Bone Fracture [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
    Days from randomization until bone fracture. If no event, then censoring occurs at earliest of termination date or efficacy cutoff date of 30 Mar 2008. Kaplan-Meier estimate of the mean


Enrollment: 17802
Study Start Date: February 2003
Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Rosuvastatin
Rosuvastatin 20 mg once daily
Drug: Rosuvastatin
Oral
Other Name: Crestor
Placebo Comparator: Placebo
Placebo once daily
Other: Placebo
Oral

Detailed Description:

AstraZeneca announced it has decided to stop the CRESTOR JUPITER clinical study early based on a recommendation from an Independent Data Monitoring Board and the JUPITER Steering Committee, which met on March 29, 2008. The study will be stopped early because there is unequivocal evidence of a reduction in cardiovascular morbidity and mortality amongst patients who received CRESTOR when compared to placebo.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Men 50 years or older, women 60 years or older
  • Low to normal levels of low density lipoprotein (LDL) cholesterol (< 130mg/dL)
  • Elevated levels of C-Reactive Protein (CRP) > 2.0 mg/L

Exclusion Criteria:

  • History of cardiovascular or cerebrovascular events
  • Active liver disease
  • Diabetes mellitus
  • Uncontrolled hypertension or hypothyroidism
  • History of certain malignancies
  • Chronic inflammatory conditions
  • History of alcohol or drug abuse
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00239681

  Hide Study Locations
Locations
United States, Alabama
Research Site
Birmingham, Alabama, United States
Research Site
Calera, Alabama, United States
Research Site
Columbiana, Alabama, United States
Research Site
Decatur, Alabama, United States
Research Site
Graysville, Alabama, United States
Research Site
Haleyville, Alabama, United States
Research Site
Hartselle, Alabama, United States
Research Site
Huntsville, Alabama, United States
Research Site
Mobile, Alabama, United States
Research Site
Montgomery, Alabama, United States
Research Site
Muscle Shoals, Alabama, United States
Research Site
South Birmingham, Alabama, United States
Research Site
Tuscumbia, Alabama, United States
United States, Arizona
Research Site
Mesa, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Scottsdale, Arizona, United States
Research Site
Tucson, Arizona, United States
United States, Arkansas
Research Site
Fayetteville, Arkansas, United States
Research Site
Hot Springs, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Pine Bluff, Arkansas, United States
United States, California
Research Site
Alhambra, California, United States
Research Site
Azusa, California, United States
Research Site
Berkeley, California, United States
Research Site
Beverly Hills, California, United States
Research Site
Burlingame, California, United States
Research Site
Carmichael, California, United States
Research Site
Concord, California, United States
Research Site
Culver City, California, United States
Research Site
Daly City, California, United States
Research Site
Folsom, California, United States
Research Site
Foothill Ranch, California, United States
Research Site
Fountain Valley, California, United States
Research Site
Fresno, California, United States
Research Site
Garden Grove, California, United States
Research Site
Inglewood, California, United States
Research Site
Irvine, California, United States
Research Site
La Jolla, California, United States
Research Site
La Mesa, California, United States
Research Site
Languna Niguel, California, United States
Research Site
Long Beach, California, United States
Research Site
Los Angeles, California, United States
Research Site
Los Gatos, California, United States
Research Site
Mission Hills, California, United States
Research Site
Mission Viejo, California, United States
Research Site
Modesto, California, United States
Research Site
Newport Beach, California, United States
Research Site
Norwalk, California, United States
Research Site
Orange, California, United States
Research Site
Orangevale, California, United States
Research Site
Palm Desert, California, United States
Research Site
Pasadena, California, United States
Research Site
Pismo Beach, California, United States
Research Site
Pomona, California, United States
Research Site
Riverside, California, United States
Research Site
Roseville, California, United States
Research Site
Sacramento, California, United States
Research Site
San Diego, California, United States
Research Site
San Jose, California, United States
Research Site
San Ramon, California, United States
Research Site
Santa Ana, California, United States
Research Site
Santa Monica, California, United States
Research Site
Thousand Oaks, California, United States
Research Site
Torrance, California, United States
Research Site
Upland, California, United States
Research Site
Ventura, California, United States
Research Site
Vista, California, United States
Research Site
Walnut Creek, California, United States
Research Site
Westlake Village, California, United States
United States, Colorado
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Denver, Colorado, United States
Research Site
Fort Collins, Colorado, United States
Research Site
Golden, Colorado, United States
Research Site
Highlands Ranch, Colorado, United States
Research Site
Littleton, Colorado, United States
Research Site
Loveland, Colorado, United States
United States, Connecticut
Research Site
Avon, Connecticut, United States
Research Site
Bristol, Connecticut, United States
Research Site
Hartford, Connecticut, United States
Research Site
Stamford, Connecticut, United States
Research Site
Trumbull, Connecticut, United States
Research Site
West Hartford, Connecticut, United States
United States, Delaware
Research Site
Newark, Delaware, United States
Research Site
Wlimington, Delaware, United States
United States, District of Columbia
Research Site
Washington, District of Columbia, United States
United States, Florida
Research Site
Apopka, Florida, United States
Research Site
Beverly Hills, Florida, United States
Research Site
Cape Coral, Florida, United States
Research Site
Clearwater, Florida, United States
Research Site
Cooper City, Florida, United States
Research Site
Crystal River, Florida, United States
Research Site
Davie, Florida, United States
Research Site
Deerfield Beach, Florida, United States
Research Site
Delray Beach, Florida, United States
Research Site
Fort Lauderdale, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
Lakeland, Florida, United States
Research Site
Largo, Florida, United States
Research Site
Margate, Florida, United States
Research Site
Miami, Florida, United States
Research Site
North Miami Beach, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Ormond Beach, Florida, United States
Research Site
Palm Harbor, Florida, United States
Research Site
Pensacola, Florida, United States
Research Site
Port Charlotte, Florida, United States
Research Site
Port Orange, Florida, United States
Research Site
Sarasota, Florida, United States
Research Site
Sebastian, Florida, United States
Research Site
Tamarac, Florida, United States
Research Site
Tampa, Florida, United States
Research Site
Vero Beach, Florida, United States
Research Site
West Palm Beach, Florida, United States
United States, Georgia
Research Site
Atlanta, Georgia, United States
Research Site
Augusta, Georgia, United States
Research Site
Blue Ridge, Georgia, United States
Research Site
Brunswick, Georgia, United States
Research Site
Columbus, Georgia, United States
Research Site
Conyers, Georgia, United States
Research Site
Decatur, Georgia, United States
Research Site
Fayetteville, Georgia, United States
Research Site
Suwanee, Georgia, United States
Research Site
Woodstock, Georgia, United States
United States, Idaho
Research Site
Idaho Falls, Idaho, United States
Research Site
Meridian, Idaho, United States
United States, Illinois
Research Site
Aurora, Illinois, United States
Research Site
Champaign, Illinois, United States
Research Site
Chicago, Illinois, United States
Research Site
Gurnee, Illinois, United States
Research Site
Lake Road, Illinois, United States
Research Site
Melrose Park, Illinois, United States
Research Site
Morton, Illinois, United States
Research Site
O'fallon, Illinois, United States
Research Site
Orland Park, Illinois, United States
Research Site
Springfield, Illinois, United States
Research Site
Sterling, Illinois, United States
Research Site
Vernon Hills, Illinois, United States
United States, Indiana
Research Site
Avon, Indiana, United States
Research Site
Evansville, Indiana, United States
Research Site
Granger, Indiana, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Jeffersonville, Indiana, United States
Research Site
Munster, Indiana, United States
Research Site
Newburgh, Indiana, United States
Research Site
Valparaiso, Indiana, United States
United States, Iowa
Research Site
Des Moines, Iowa, United States
Research Site
Dubuque, Iowa, United States
Research Site
Iowa City, Iowa, United States
Research Site
West Des Moines, Iowa, United States
United States, Kansas
Research Site
Leavenworth, Kansas, United States
Research Site
Olathe, Kansas, United States
Research Site
Overland Park, Kansas, United States
Research Site
Shawnee Mission, Kansas, United States
Research Site
Topeka, Kansas, United States
Research Site
Wichita, Kansas, United States
United States, Kentucky
Research Site
Evansville, Kentucky, United States
Research Site
Lexington, Kentucky, United States
Research Site
Louisville, Kentucky, United States
United States, Louisiana
Research Site
Baton Rouge, Louisiana, United States
Research Site
Covington, Louisiana, United States
Research Site
Houma, Louisiana, United States
Research Site
Lake Charles, Louisiana, United States
Research Site
Marrero, Louisiana, United States
Research Site
New Orleans, Louisiana, United States
Research Site
Shreveport, Louisiana, United States
United States, Maine
Research Site
Auburn, Maine, United States
Research Site
Bangor, Maine, United States
Research Site
Portland, Maine, United States
Research Site
S Portland, Maine, United States
Research Site
Sanford, Maine, United States
United States, Maryland
Research Site
Baltimore, Maryland, United States
Research Site
Charlotte Hall, Maryland, United States
Research Site
Glen Burnie, Maryland, United States
Research Site
Hagerstown, Maryland, United States
Research Site
Prince Frederick, Maryland, United States
Research Site
Rockville, Maryland, United States
Research Site
Towson, Maryland, United States
United States, Massachusetts
Research Site
Ayer, Massachusetts, United States
Research Site
Boston, Massachusetts, United States
Research Site
Burlington, Massachusetts, United States
Research Site
East Bridgewater, Massachusetts, United States
Research Site
Haverhill, Massachusetts, United States
Research Site
Natick, Massachusetts, United States
Research Site
Newton, Massachusetts, United States
Research Site
Springfield, Massachusetts, United States
Research Site
West Yarmouth, Massachusetts, United States
Research Site
Worcester, Massachusetts, United States
United States, Michigan
Research Site
Berkley, Michigan, United States
Research Site
Dearborn, Michigan, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Livonia, Michigan, United States
Research Site
Petoskey, Michigan, United States
Research Site
Portage, Michigan, United States
Research Site
St. Joseph, Michigan, United States
Research Site
Troy, Michigan, United States
Research Site
Warren, Michigan, United States
United States, Minnesota
Research Site
Chaska, Minnesota, United States
Research Site
Duluth, Minnesota, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Rochester, Minnesota, United States
Research Site
St. Paul, Minnesota, United States
United States, Mississippi
Research Site
Gulfport, Mississippi, United States
Research Site
Jackson, Mississippi, United States
Research Site
Olive Branch, Mississippi, United States
Research Site
Picayune, Mississippi, United States
Research Site
Port Gibson, Mississippi, United States
United States, Missouri
Research Site
Chesterfield, Missouri, United States
Research Site
Excelsior Springs, Missouri, United States
Research Site
Jefferson City, Missouri, United States
Research Site
Kansas City, Missouri, United States
Research Site
Manchester, Missouri, United States
Research Site
Mexico, Missouri, United States
Research Site
Rolla, Missouri, United States
Research Site
Shawnee Mission, Missouri, United States
Research Site
Springfield, Missouri, United States
Research Site
St Charles, Missouri, United States
Research Site
St Louis, Missouri, United States
Research Site
Washington, Missouri, United States
Research Site
Wentzville, Missouri, United States
United States, Montana
Research Site
Anaconda, Montana, United States
Research Site
Butte, Montana, United States
Research Site
Kalispell, Montana, United States
Research Site
Missoula, Montana, United States
United States, Nebraska
Research Site
Grand Island, Nebraska, United States
Research Site
Omaha, Nebraska, United States
United States, Nevada
Research Site
Henderson, Nevada, United States
Research Site
Las Vegas, Nevada, United States
Research Site
Pahrump, Nevada, United States
United States, New Hampshire
Research Site
Nashua, New Hampshire, United States
United States, New Jersey
Research Site
Bloomfield, New Jersey, United States
Research Site
Brick, New Jersey, United States
Research Site
Cherry Hill, New Jersey, United States
Research Site
Elizabeth, New Jersey, United States
Research Site
Englewood Cliffs, New Jersey, United States
Research Site
Morristown, New Jersey, United States
Research Site
Newark, New Jersey, United States
Research Site
Northbrunswick, New Jersey, United States
Research Site
Passaic, New Jersey, United States
Research Site
Teaneck, New Jersey, United States
Research Site
Trenton, New Jersey, United States
Research Site
West Caldwell, New Jersey, United States
United States, New Mexico
Research Site
Albuquerque, New Mexico, United States
Research Site
Los Alamos, New Mexico, United States
Research Site
Rio Rancho, New Mexico, United States
United States, New York
Research Site
Albany, New York, United States
Research Site
Binghamton, New York, United States
Research Site
Bowmansville, New York, United States
Research Site
Bronx, New York, United States
Research Site
Bronxville, New York, United States
Research Site
Brooklyn, New York, United States
Research Site
Buffalo, New York, United States
Research Site
Camillus, New York, United States
Research Site
E Syracuse, New York, United States
Research Site
East Islip, New York, United States
Research Site
Fayetteville, New York, United States
Research Site
Lake Success, New York, United States
Research Site
Mamaroneck, New York, United States
Research Site
Mount Vernon, New York, United States
Research Site
New Hartford, New York, United States
Research Site
New Hyde Park, New York, United States
Research Site
New York, New York, United States
Research Site
Niagara Falls, New York, United States
Research Site
Poughkeepsie, New York, United States
Research Site
Riverhead, New York, United States
Research Site
Rochester, New York, United States
Research Site
Syracuse, New York, United States
Research Site
Tonawanda, New York, United States
Research Site
Williamsville, New York, United States
United States, North Carolina
Research Site
Asheville, North Carolina, United States
Research Site
Burlington, North Carolina, United States
Research Site
Cary, North Carolina, United States
Research Site
Chapel Hill, North Carolina, United States
Research Site
Charlotte, North Carolina, United States
Research Site
Durham, North Carolina, United States
Research Site
Fayetteville, North Carolina, United States
Research Site
Lenoir, North Carolina, United States
Research Site
Lexington, North Carolina, United States
Research Site
Raleigh, North Carolina, United States
Research Site
Statesville, North Carolina, United States
Research Site
Winston-salem, North Carolina, United States
United States, North Dakota
Research Site
Fargo, North Dakota, United States
United States, Ohio
Research Site
Akron, Ohio, United States
Research Site
Athens, Ohio, United States
Research Site
Bellbrook, Ohio, United States
Research Site
Canal Fulton, Ohio, United States
Research Site
Centerville, Ohio, United States
Research Site
Chesterland, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Dayton, Ohio, United States
Research Site
Mansfield, Ohio, United States
Research Site
Massillon, Ohio, United States
Research Site
Maumee, Ohio, United States
Research Site
Wadsworth, Ohio, United States
Research Site
Warren, Ohio, United States
Research Site
Zanesville, Ohio, United States
United States, Oklahoma
Research Site
Guthrie, Oklahoma, United States
Research Site
Muskogee, Oklahoma, United States
Research Site
Oklahoma City, Oklahoma, United States
Research Site
Tulsa, Oklahoma, United States
Research Site
Yukon, Oklahoma, United States
United States, Oregon
Research Site
Corvallis, Oregon, United States
Research Site
Dallas, Oregon, United States
Research Site
Eugene, Oregon, United States
Research Site
Lake Oswego, Oregon, United States
Research Site
Medford, Oregon, United States
Research Site
Milwaukie, Oregon, United States
Research Site
Portland, Oregon, United States
Research Site
Springfield, Oregon, United States
United States, Pennsylvania
Research Site
Altoona, Pennsylvania, United States
Research Site
Beaver, Pennsylvania, United States
Research Site
Bloomsburg, Pennsylvania, United States
Research Site
Broomall, Pennsylvania, United States
Research Site
Camp Hill, Pennsylvania, United States
Research Site
Connellsville, Pennsylvania, United States
Research Site
Downingtown, Pennsylvania, United States
Research Site
Erie, Pennsylvania, United States
Research Site
Feasterville, Pennsylvania, United States
Research Site
Fleetwood, Pennsylvania, United States
Research Site
Harleysville, Pennsylvania, United States
Research Site
Harrisburg, Pennsylvania, United States
Research Site
Jersey Shore, Pennsylvania, United States
Research Site
King of Prussia, Pennsylvania, United States
Research Site
Lansdale, Pennsylvania, United States
Research Site
Lansdowne, Pennsylvania, United States
Research Site
Lewisburg, Pennsylvania, United States
Research Site
Lewistown, Pennsylvania, United States
Research Site
Lock Haven, Pennsylvania, United States
Research Site
McMurry, Pennsylvania, United States
Research Site
Melrose Park, Pennsylvania, United States
Research Site
Norristown, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Plymouth Meeting, Pennsylvania, United States
Research Site
Reading, Pennsylvania, United States
Research Site
Scotland, Pennsylvania, United States
Research Site
Sellersville, Pennsylvania, United States
Research Site
Souderton, Pennsylvania, United States
Research Site
Springfield, Pennsylvania, United States
Research Site
State College, Pennsylvania, United States
Research Site
Stoneboro, Pennsylvania, United States
Research Site
Tipton, Pennsylvania, United States
Research Site
Uniontown, Pennsylvania, United States
Research Site
Upland, Pennsylvania, United States
Research Site
Wallingford, Pennsylvania, United States
Research Site
Warminster, Pennsylvania, United States
Research Site
West Grove, Pennsylvania, United States
Research Site
West Reading, Pennsylvania, United States
Research Site
Wilkes-barre, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
United States, Rhode Island
Research Site
Cranston, Rhode Island, United States
Research Site
Johnston, Rhode Island, United States
Research Site
Pawtucket, Rhode Island, United States
Research Site
Providence, Rhode Island, United States
United States, South Carolina
Research Site
Charleston, South Carolina, United States
Research Site
Greenville, South Carolina, United States
Research Site
Greer, South Carolina, United States
Research Site
Hampton, South Carolina, United States
Research Site
Moncks Corner, South Carolina, United States
Research Site
Mt Pleasant, South Carolina, United States
Research Site
Orangeburg, South Carolina, United States
Research Site
Simpsonville, South Carolina, United States
United States, South Dakota
Research Site
Sioux Falls, South Dakota, United States
United States, Tennessee
Research Site
Bristol, Tennessee, United States
Research Site
Chattanooga, Tennessee, United States
Research Site
Clarksville, Tennessee, United States
Research Site
Fayetteville, Tennessee, United States
Research Site
Germantown, Tennessee, United States
Research Site
Hendersonville, Tennessee, United States
Research Site
Jefferson City, Tennessee, United States
Research Site
Johnson City, Tennessee, United States
Research Site
Memphis, Tennessee, United States
Research Site
Morristown, Tennessee, United States
Research Site
Nashville, Tennessee, United States
United States, Texas
Research Site
Arlington, Texas, United States
Research Site
Austin, Texas, United States
Research Site
Carrollton, Texas, United States
Research Site
Colleyville, Texas, United States
Research Site
Corpus Christi, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
El Paso, Texas, United States
Research Site
Fort Worth, Texas, United States
Research Site
Friendswood, Texas, United States
Research Site
Ft Worth, Texas, United States
Research Site
Grapevine, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Irving, Texas, United States
Research Site
Lake Jackson, Texas, United States
Research Site
Lubbock, Texas, United States
Research Site
N Richland Hills, Texas, United States
Research Site
New Braunfels, Texas, United States
Research Site
Pharr, Texas, United States
Research Site
Plano, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Seguin, Texas, United States
Research Site
Sugar Land, Texas, United States
Research Site
The Woodlands, Texas, United States
Research Site
Tyler, Texas, United States
United States, Utah
Research Site
Bountiful, Utah, United States
Research Site
Nephi, Utah, United States
Research Site
Salt Lake City, Utah, United States
United States, Vermont
Research Site
Burlington, Vermont, United States
United States, Virginia
Research Site
Alexandria, Virginia, United States
Research Site
Arlington, Virginia, United States
Research Site
Burke, Virginia, United States
Research Site
Charlottesville, Virginia, United States
Research Site
Hampton, Virginia, United States
Research Site
Hayes, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Quinton, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Springfield, Virginia, United States
Research Site
Stuart, Virginia, United States
Research Site
Suffolk, Virginia, United States
Research Site
Weber City, Virginia, United States
Research Site
Yorktown, Virginia, United States
United States, Washington
Research Site
Burien, Washington, United States
Research Site
Everett, Washington, United States
Research Site
Gig Harbor, Washington, United States
Research Site
Olympia, Washington, United States
Research Site
Seattle, Washington, United States
Research Site
Spokane, Washington, United States
Research Site
Wenatchee, Washington, United States
United States, West Virginia
Research Site
Charleston, West Virginia, United States
Research Site
Lewisburg, West Virginia, United States
United States, Wisconsin
Research Site
Beloit, Wisconsin, United States
Research Site
Green Bay, Wisconsin, United States
Research Site
Madison, Wisconsin, United States
Research Site
Menomonee Falls, Wisconsin, United States
Research Site
Milwaukee, Wisconsin, United States
Argentina
Research Site
Quilmes, Buenos Aires - Argentina, Argentina
Research Site
Ramos Mejia, Buenos Aires Argentina, Argentina
Research Site
San Isidro, Buenos Aires- Argentina, Argentina
Research Site
Capital Federal, Buenos Aires, Argentina
Research Site
Pilar, Buenos Aires, Argentina
Research Site
Cordoba, Cordoba - Argentina, Argentina
Research Site
Rosario, Santa Fe- Argentina, Argentina
Research Site
San Miguel de Tucuman, Tucuman / Argentina, Argentina
Research Site
Tucuman, Tucuman-argentina, Argentina
Research Site
Salta, Argentina
Belgium
Research Site
Alsemberg, Belgium
Research Site
ANS, Belgium
Research Site
Anthee, Belgium
Research Site
Auvelais, Belgium
Research Site
Baisy-thy, Belgium
Research Site
Bertrix, Belgium
Research Site
Betekom, Belgium
Research Site
Boechout, Belgium
Research Site
Braine-l 'alleud, Belgium
Research Site
Brussels, Belgium
Research Site
Burdinne, Belgium
Research Site
Cerexhe-heuseux, Belgium
Research Site
Champion, Belgium
Research Site
Chenee, Belgium
Research Site
De Pinte, Belgium
Research Site
Deurne (antwerpen), Belgium
Research Site
Dour, Belgium
Research Site
Ekeren, Belgium
Research Site
Embourg, Belgium
Research Site
Evergem, Belgium
Research Site
Genk, Belgium
Research Site
Genly, Belgium
Research Site
Gozee, Belgium
Research Site
Grivegnee, Belgium
Research Site
Halen, Belgium
Research Site
Hasselt, Belgium
Research Site
Heurne, Belgium
Research Site
Heusden, Belgium
Research Site
Hove, Belgium
Research Site
Kessel-lo, Belgium
Research Site
Komen, Belgium
Research Site
Kraainem, Belgium
Research Site
Landen, Belgium
Research Site
Lauwe, Belgium
Research Site
Leopoldsburg, Belgium
Research Site
Leuven, Belgium
Research Site
Libin, Belgium
Research Site
Linkebeek, Belgium
Research Site
Lommel, Belgium
Research Site
Marchienne-au-pont, Belgium
Research Site
Marchovelette, Belgium
Research Site
Massemen, Belgium
Research Site
Mechelen-aan-de-maas, Belgium
Research Site
Melsbroek, Belgium
Research Site
Moerkerke, Belgium
Research Site
Mont-sur-marchienne, Belgium
Research Site
Moorsel, Belgium
Research Site
Mouscron, Belgium
Research Site
Natoye, Belgium
Research Site
Oostham, Belgium
Research Site
Opgrimbie (maasmechelen), Belgium
Research Site
Oudenaarde, Belgium
Research Site
Paal, Belgium
Research Site
Puurs, Belgium
Research Site
Ronquieres, Belgium
Research Site
Ronse, Belgium
Research Site
Rumst, Belgium
Research Site
Saint-medard, Belgium
Research Site
Schoonaarde, Belgium
Research Site
Schuiferskapelle, Belgium
Research Site
Sint-gillis-waas, Belgium
Research Site
Steenokkerzeel, Belgium
Research Site
Tavier, Belgium
Research Site
Tessenderlo, Belgium
Research Site
Thuin, Belgium
Research Site
Tielt, Belgium
Research Site
Tremelo, Belgium
Research Site
Trois-ponts, Belgium
Research Site
Turnhout, Belgium
Research Site
Vilvoorde, Belgium
Research Site
Waremme, Belgium
Research Site
Weerde, Belgium
Research Site
Wezembeek- Oppem, Belgium
Research Site
Zoersel, Belgium
Brazil
Research Site
Maceio, Alagoas, Brazil
Research Site
Salvador, BA, Brazil
Research Site
Fortaleza, CE, Brazil
Research Site
Goiagoianiania, Goias, Brazil
Research Site
Belo Horizonte, MG, Brazil
Research Site
Passo Fundo, Rio Grande Do Sul, Brazil
Research Site
Rio de Janeiro, RJ, Brazil
Research Site
Porto Alegre, RS, Brazil
Research Site
Santos, Sao Paulo, Brazil
Research Site
Sao Jose Do Rio Preto, Sao Paulo, Brazil
Research Site
Botucatu, SP, Brazil
Research Site
S.j.rio Preto, SP, Brazil
Research Site
Campinas, Brazil
Research Site
Sao Paulo, Brazil
Bulgaria
Research Site
Dimitrovgrad, Bulgaria
Research Site
Haskovo, Bulgaria
Research Site
Pleven, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Russe, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Veliko Tarnovo, Bulgaria
Canada, Alberta
Research Site
Calgary, Alberta, Canada
Research Site
Edmonton, Alberta, Canada
Canada, British Columbia
Research Site
Chilliwack, British Columbia, Canada
Research Site
Coquitlam, British Columbia, Canada
Research Site
Kelowna, British Columbia, Canada
Research Site
Langley, British Columbia, Canada
Research Site
New Westminister, British Columbia, Canada
Research Site
Penticton, British Columbia, Canada
Research Site
Surrey, British Columbia, Canada
Research Site
Victoria, British Columbia, Canada
Canada, Manitoba
Research Site
Portage La Prairie, Manitoba, Canada
Research Site
Winnipeg, Manitoba, Canada
Canada, New Brunswick
Research Site
Grand Bay - Westfield, New Brunswick, Canada
Research Site
Moncton, New Brunswick, Canada
Research Site
Nackawic, New Brunswick, Canada
Research Site
Saint John, New Brunswick, Canada
Research Site
Woodstock, New Brunswick, Canada
Canada, Newfoundland and Labrador
Research Site
Bay Roberts, Newfoundland and Labrador, Canada
Research Site
Carbonear, Newfoundland and Labrador, Canada
Research Site
Conception Bay South, Newfoundland and Labrador, Canada
Research Site
Holyrood, Newfoundland and Labrador, Canada
Research Site
Mount Pearl, Newfoundland and Labrador, Canada
Research Site
St. John's, Newfoundland and Labrador, Canada
Canada, Nova Scotia
Research Site
Amherst, Nova Scotia, Canada
Research Site
Antigonish, Nova Scotia, Canada
Research Site
Digby, Nova Scotia, Canada
Research Site
Halifax, Nova Scotia, Canada
Research Site
Windsor, Nova Scotia, Canada
Canada, Ontario
Research Site
Bolton, Ontario, Canada
Research Site
Brampton, Ontario, Canada
Research Site
Burlington, Ontario, Canada
Research Site
Cambridge, Ontario, Canada
Research Site
Corunna, Ontario, Canada
Research Site
Courtice, Ontario, Canada
Research Site
Etobicoke, Ontario, Canada
Research Site
Exeter, Ontario, Canada
Research Site
Hamilton, Ontario, Canada
Research Site
Ingersoll, Ontario, Canada
Research Site
Kingston, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Markham, Ontario, Canada
Research Site
Newmarket, Ontario, Canada
Research Site
Niagara Falls, Ontario, Canada
Research Site
North Bay, Ontario, Canada
Research Site
North York, Ontario, Canada
Research Site
Orleans, Ontario, Canada
Research Site
Oshawa, Ontario, Canada
Research Site
Ottawa, Ontario, Canada
Research Site
Perth, Ontario, Canada
Research Site
Peterborough, Ontario, Canada
Research Site
Renfrew, Ontario, Canada
Research Site
Sarnia, Ontario, Canada
Research Site
Scarborough, Ontario, Canada
Research Site
Smith Falls, Ontario, Canada
Research Site
St Catherines, Ontario, Canada
Research Site
Stirling, Ontario, Canada
Research Site
Sudbury, Ontario, Canada
Research Site
Thornhill, Ontario, Canada
Research Site
Thunder Bay, Ontario, Canada
Research Site
Tillsonburg, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Windsor, Ontario, Canada
Research Site
Woodstock, Ontario, Canada
Canada, Prince Edward Island
Research Site
Charlottetown, Prince Edward Island, Canada
Canada, Quebec
Research Site
Chicoutimi, Quebec, Canada
Research Site
Courcelette, Quebec, Canada
Research Site
Drummonville, Quebec, Canada
Research Site
Gatineau, Quebec, Canada
Research Site
Granby, Quebec, Canada
Research Site
Greenfield Park, Quebec, Canada
Research Site
Lasalle, Quebec, Canada
Research Site
Laval, Quebec, Canada
Research Site
Longueuil, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Pointe-claire, Quebec, Canada
Research Site
Saint-georges, Quebec, Canada
Research Site
Saint-marc-des-carrieres, Quebec, Canada
Research Site
Sainte-catherine, Quebec, Canada
Research Site
Sainte-julie, Quebec, Canada
Research Site
Sherbrooke, Quebec, Canada
Research Site
Trois-rivieres, Quebec, Canada
Research Site
Vanier, Quebec, Canada
Canada, Saskatchewan
Research Site
Regina, Saskatchewan, Canada
Research Site
Saskatoon, Saskatchewan, Canada
Canada
Research Site
Quebec, Canada
Chile
Research Site
Temuco, Novena Region, Chile
Research Site
Santiago, Region Metropolitana, Chile
Colombia
Research Site
Medellin, Antioquia, Colombia
Research Site
Barranquilla, Atlantico, Colombia
Research Site
Cartagena, Bolivar, Colombia
Research Site
Pereira, Risaralda, Colombia
Research Site
Bucaramanga, Santander, Colombia
Research Site
Floridablanca, Santander, Colombia
Research Site
Cali, Valle, Colombia
Research Site
Bogota, Colombia
Costa Rica
Research Site
Desamparados, San Jose, Costa Rica
Research Site
Escazu, San Jose, Costa Rica
Research Site
San Pedro de Montes de Oca, San Jose, Costa Rica
Research Site
Heredia, Costa Rica
Denmark
Research Site
Gentofte, Denmark
Research Site
Glostrup, Denmark
Research Site
Herlev, Denmark
Research Site
Hillerod, Denmark
Research Site
Odense C, Denmark
El Salvador
Research Site
El Salvador, San Salvador, El Salvador
Research Site
Salvador, El Salvador
Research Site
San Salvador, El Salvador
Estonia
Research Site
Saku, Harju County, Estonia
Research Site
Parnu, Estonia
Research Site
Rakvere, Estonia
Research Site
Tallinn, Estonia
Research Site
Tartu, Estonia
Research Site
Viljandi County, Estonia
Germany
Research Site
Berlin, Germany
Research Site
Bochum, Germany
Research Site
Chemnitz, Germany
Research Site
Dortmund, Germany
Research Site
Dresden, Germany
Research Site
Frankfurt, Germany
Research Site
Gorlitz, Germany
Research Site
Hamburg, Germany
Research Site
Kunzing, Germany
Research Site
Leipzig, Germany
Research Site
Magdeburg, Germany
Research Site
Nurnberg, Germany
Research Site
ULM, Germany
Research Site
Witten, Germany
Israel
Research Site
Kiryat Hadassah, Jerusalem, Israel
Research Site
Ashkelon Shore, Israel
Research Site
Beer Yakov, Israel
Research Site
Haifa, Israel
Research Site
Holon, Israel
Research Site
Jerusalem, Israel
Research Site
Kfar-saba, Israel
Research Site
Safed, Israel
Research Site
Tel Aviv, Israel
Research Site
Tel-hashomer, Israel
Research Site
Zrifin, Israel
Mexico
Research Site
Mexico City, D.F, Mexico
Research Site
Guadalajara, Jalisco, Mexico
Research Site
Monterrey, Nuevo Leon, Mexico
Research Site
Culiacan, Sinaloa, Mexico
Research Site
San Luis Potosi, SLP, Mexico
Research Site
Aguascalientes, Mexico
Netherlands
Research Site
Alkmaar, Netherlands
Research Site
Amersfoort, Netherlands
Research Site
Amsterdam, Netherlands
Research Site
Breda, Netherlands
Research Site
Den Haag, Netherlands
Research Site
Deventer, Netherlands
Research Site
Eindhoven, Netherlands
Research Site
Gouda, Netherlands
Research Site
Groningen, Netherlands
Research Site
Hoorn, Netherlands
Research Site
Leiden, Netherlands
Research Site
Nijmegen, Netherlands
Research Site
Rotterdam, Netherlands
Research Site
Tilburg, Netherlands
Research Site
Utrecht, Netherlands
Research Site
Velp, Netherlands
Research Site
Zoetermeer, Netherlands
Norway
Research Site
Bekkestua, Norway
Research Site
Bergen, Norway
Research Site
Boverbru, Norway
Research Site
Elverum, Norway
Research Site
Flatasen, Norway
Research Site
Fredrikstad, Norway
Research Site
Halden, Norway
Research Site
Heimdal, Norway
Research Site
Kristiansand, Norway
Research Site
Laksevag, Norway
Research Site
Lena, Norway
Research Site
Lierskogen, Norway
Research Site
Lovenstad, Norway
Research Site
Lysaker, Norway
Research Site
Moelv, Norway
Research Site
Moss, Norway
Research Site
Oslo, Norway
Research Site
Osteras, Norway
Research Site
Paradis, Norway
Research Site
Radal, Norway
Research Site
Randaberg, Norway
Research Site
Skedsmokorset, Norway
Research Site
SKI, Norway
Research Site
Skiptvet, Norway
Research Site
Snaroya, Norway
Research Site
Sogndal, Norway
Research Site
Spikkestad, Norway
Research Site
Stavanger, Norway
Research Site
Strommen, Norway
Research Site
Svelvik, Norway
Research Site
Trollasen, Norway
Research Site
Trondheim, Norway
Panama
Research Site
Panama, Panama
Poland
Research Site
Aleksandrow Lodzki, Poland
Research Site
Bydgoszcz, Poland
Research Site
Bytom, Poland
Research Site
Chodziez, Poland
Research Site
Chorzow, Poland
Research Site
Gdansk, Poland
Research Site
Gliwice, Poland
Research Site
Jelcz-laskowice, Poland
Research Site
Karpacz, Poland
Research Site
Katowice, Poland
Research Site
Koluszki, Poland
Research Site
Krakow, Poland
Research Site
Linia, Poland
Research Site
Lodz, Poland
Research Site
Lublin, Poland
Research Site
Nowogard, Poland
Research Site
Olawa, Poland
Research Site
Olsztyn, Poland
Research Site
Opalenica, Poland
Research Site
Opole, Poland
Research Site
Ostrow Wielkopolski, Poland
Research Site
Piekary Slaskie, Poland
Research Site
Poznan, Poland
Research Site
Pulawy, Poland
Research Site
Radom, Poland
Research Site
Radziejow, Poland
Research Site
Rybnik, Poland
Research Site
Sieradz, Poland
Research Site
Skierniewice, Poland
Research Site
Slupca, Poland
Research Site
Sobotka, Poland
Research Site
Sopot, Poland
Research Site
Szczecin, Poland
Research Site
Tarnow, Poland
Research Site
Torun, Poland
Research Site
Trzcianka, Poland
Research Site
Turek, Poland
Research Site
Wabrzezno, Poland
Research Site
Warszawa, Poland
Research Site
Wejherowo, Poland
Research Site
Wroclaw, Poland
Research Site
Zabrze, Poland
Puerto Rico
Research Site
Aguas Buenas, Puerto Rico
Research Site
Caguas, Puerto Rico
Research Site
Cidra, Puerto Rico
Research Site
Levittown-toa Baja, Puerto Rico
Research Site
Ponce, Puerto Rico
Research Site
San Juan, Puerto Rico
Romania
Research Site
Cluj Napoca, Cluj, Romania
Research Site
Timisoara, Timis, Romania
Research Site
Brasov, Romania
Research Site
Bucharest, Romania
Research Site
Bucuresti, Romania
Russian Federation
Research Site
Ekaterinburg, Russian Federation
Research Site
Kemerovo, Russian Federation
Research Site
Krasnoyarsk, Russian Federation
Research Site
Moscow, Russian Federation
Research Site
Novosibirsk, Russian Federation
Research Site
Saratov, Russian Federation
Research Site
St-petersburg, Russian Federation
Research Site
Toliatti, Russian Federation
Research Site
Tomsk, Russian Federation
Research Site
Tyumen, Russian Federation
Research Site
Voronezh, Russian Federation
Research Site
Yaroslavl, Russian Federation
South Africa
Research Site
Claremont, Cape Province, South Africa
Research Site
Athlone, Cape Town, South Africa
Research Site
Florida Park, Gauteng, South Africa
Research Site
Lenasia, Gauteng, South Africa
Research Site
Pretoria, Gauteng, South Africa
Research Site
Witbank, Gauteng, South Africa
Research Site
Durban, Kwazulu Natal, South Africa
Research Site
Umkomaas, Kwazulu Natal, South Africa
Research Site
Morningside Manor, Morningside, South Africa
Research Site
Korsten, Port Elizabeth, South Africa
Research Site
Hillcrest, Pretoria, South Africa
Research Site
Benoni, South Africa
Research Site
Halfway House, South Africa
Research Site
Johannesburg, South Africa
Research Site
Lakeview, Retreat, South Africa
Research Site
Rustenburg, South Africa
Research Site
Somerset West, South Africa
Research Site
Vanderbijlpark, South Africa
Research Site
Worcester, South Africa
Switzerland
Research Site
Olten, Schweiz, Switzerland
United Kingdom
Research Site
Reading, Berkshire, United Kingdom
Research Site
Annan, Dumfries and Galloway, United Kingdom
Research Site
Blantyre, Lanarkshire, United Kingdom
Research Site
Hamilton, Lanarkshire, United Kingdom
Research Site
Strathaven, Lanarkshire, United Kingdom
Research Site
Wishaw, Lanarkshire, United Kingdom
Research Site
Paisley, Renfrewshire, United Kingdom
Research Site
Airdrie, Scotland, United Kingdom
Research Site
Glasgow, Scotland, United Kingdom
Research Site
Barrhead, United Kingdom
Research Site
Bellshill, United Kingdom
Research Site
Birmingham, United Kingdom
Research Site
Cambuslang, United Kingdom
Research Site
Cardiff, United Kingdom
Research Site
Chorley, United Kingdom
Research Site
Cumbernauld, United Kingdom
Research Site
Gourock, United Kingdom
Research Site
Greenock, United Kingdom
Research Site
Helensburgh, United Kingdom
Research Site
Kirkintilloch, United Kingdom
Research Site
Liverpool, United Kingdom
Research Site
Lockerbie, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
New Stevenson, United Kingdom
Research Site
Renfrew, United Kingdom
Research Site
Stranraer, United Kingdom
Research Site
Strathblane, United Kingdom
Research Site
Thornhill, United Kingdom
Research Site
Wolverhampton, United Kingdom
Uruguay
Research Site
Montevideo, Uruguay
Venezuela
Research Site
Maracay, Municipio Girardot, Estado Aragua, Venezuela
Research Site
Barinas, Estado Barinas, Venezuela
Research Site
Ciudad Bolivar, Estado Bolivar, Venezuela
Research Site
Puerto Ordaz, Estado Bolivar, Venezuela
Research Site
Valencia, Estado Carabobo, Venezuela
Research Site
Barquisimeto, Estado Lara, Venezuela
Research Site
Merida, Estado Merida, Venezuela
Research Site
Porlamar, Estado Nueva Esparta, Venezuela
Research Site
Maracaibo, Estado Zulia, Venezuela
Research Site
Latrinidad Caracas, Municipio Baruta, Venezuela
Research Site
Caracas, Venezuela
Research Site
Punto Fijo, Estado Falcon, Venezuela
Sponsors and Collaborators
AstraZeneca
Investigators
Study Director: Judith Hsia, MD AstraZeneca
Study Chair: Paul Ridker, MD Brigham and Women's Hospital
  More Information

Additional Information:
No publications provided by AstraZeneca

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: AstraZeneca
ClinicalTrials.gov Identifier: NCT00239681     History of Changes
Other Study ID Numbers: D3560L00030, Jupiter, 4522US/0011
Study First Received: October 13, 2005
Results First Received: August 20, 2009
Last Updated: February 6, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by AstraZeneca:
Primary prevention
Cardiovascular disease
Statin therapy
C-reactive protein

Additional relevant MeSH terms:
Rosuvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Enzyme Inhibitors
Lipid Regulating Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on July 28, 2014