Clinical-Genetic Variation in GABA/Alcohol Sensitivity (GABA-Alcohol)
The purpose of the study is to better understand how genetic factors influence individual sensitivity to alcohol.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Clinical-Genetic Variation in GABA/Alcohol Sensitivity|
Specifically, we will determine whether the subject's gene for a brain protein called GABA-alpha-6 is of the "Pro" type or "Ser" type.
|Study Start Date:||August 2002|
|Study Completion Date:||December 2008|
|Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
Genotype group Pro/Pro
Genotype group Pro/Ser
We want to find out if there are specific characteristics of a person's genes which will cause them to respond differently to alcohol. Genes are parts of the chromosomes found in the cells of our bodies which control our physical characteristics such the color of our hair, eyes, and other features. Genes are made up of molecules called "DNA" which carry the genetic information we receive from our parents. Just as genes control our physical characteristics, differences in genetic information may also explain why some people are more sensitive to alcohol or have problems drinking too much.
|Principal Investigator:||John D. Roache, Ph.D.||The University of Texas Health Science Center at San Antonio|