|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsor: | National Institute on Aging (NIA) |
|---|---|
| Information provided by: | National Institute on Aging (NIA) |
| ClinicalTrials.gov Identifier: | NCT00182949 |
Purpose
The purpose of this study is to examine the genetic risk factors for aging associated conditions.
| Condition |
|---|
|
Aging Cardiovascular Disease |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Genetics and Epidemiology of Aging-Associated Traits in the Sardinian Population (SardiNIA) |
White cells and blood samples
| Estimated Enrollment: | 6000 |
| Study Start Date: | June 2001 |
| Estimated Study Completion Date: | June 2016 |
| Estimated Primary Completion Date: | June 2016 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
1
Cohort comprises over 6,200 participants, aged 18-102, from a cluster of 4 towns in Sardinia
|
To simplify the genetic study of risk factors for aging-associated conditions, the Sardinian "founder population" is being used, which has developed to a large modern population over thousands of years without appreciable admixture from without, so that the genetic heterogeneity is relatively reduced. A cohort of 6,000 participants has been enrolled from a cluster of 4 towns. Family history, epidemiological data, and measures of 98 quantitative traits, including cardiovascular risk factors and facets of personality, have been collected. The study is now continuing with longitudinal studies, including second and third visits to repeat measures and add more traits. Full genome scans are being done with the goal of localizing and ultimately identifying genetic variants that account for 5% or more of the variance for each trait.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Residents of any of the 4 towns: Lanusei, Ilbono, Arzana and Ilini, in a valley in the providence of Ogliastra, Sardinia
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: National Institute on Aging Protocol Officer | 410-350-3947 | |
| Contact: Participant Recruitment | 011 (39) 0782480078 (Italy) |
| Italy, Sardinia | |
| Istituto di Neurogenetica e Neurofarmacologia/Italian National Research (CNR) Lanusei | Recruiting |
| Ogliastra, Sardinia, Italy | |
| Contact: Participant Recruitment 011 (39) 0782480078 | |
| Principal Investigator: Manuela Uda, MD | |
| Principal Investigator: | David Schlessinger, PhD | National Institute on Aging, Laboratory of Genetics |
More Information
| Responsible Party: | National Institute on Aging ( David Schlessinger, Ph.D. ) |
| Study ID Numbers: | AG0041 |
| Study First Received: | September 13, 2005 |
| Last Updated: | May 28, 2009 |
| ClinicalTrials.gov Identifier: | NCT00182949 History of Changes |
| Health Authority: | United States: Federal Government |
|
genetics DNA |
|
Cardiovascular Diseases |
