The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients

This study has been completed.

First Received: August 31, 2005 Last Updated: September 24, 2008 History of Changes

Sponsor:	Policlinico Hospital
Information provided by:	Policlinico Hospital
ClinicalTrials.gov Identifier:	NCT00143468

Purpose

The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.

Condition	Intervention
Acute Lung Injury ARDS	Behavioral: mechanical ventilation

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Placebo Control, Single Group Assignment, Safety Study
Official Title:	The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Barotrauma and Volutrauma

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:

Specific elastance [ Time Frame: 5 minutes ] [ Designated as safety issue: No ]

Enrollment:	100
Study Start Date:	March 2005
Study Completion Date:	May 2008
Primary Completion Date:	March 2007 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental ALI/ARDS patients and healthy subjects	Behavioral: mechanical ventilation measurement of specific lung elastance during mechanical ventilation

Detailed Description:

In sedated and paralyzed ALI/ARDS patients, we studied the specific elastance and also, we compared the specific elastance to healthy subjects during invasive mechanical ventilation.

Eligibility

Ages Eligible for Study:	16 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Stable ALI/ARDS patients during invasive mechanical ventilation

Exclusion Criteria:

Hemodynamic failure, pneumothorax

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00143468

Locations

Italy
Ospedale policlinico
milano, Italy, 20122

Sponsors and Collaborators

Policlinico Hospital

Investigators

Principal Investigator:

davide chiumello, MD

Policlinico Hospital

More Information

No publications provided by Policlinico Hospital

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Chiumello D, Carlesso E, Cadringher P, Caironi P, Valenza F, Polli F, Tallarini F, Cozzi P, Cressoni M, Colombo A, Marini JJ, Gattinoni L. Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med. 2008 Aug 15;178(4):346-55. Epub 2008 May 1.

Responsible Party:	Policlinico Hospital ( Davide Chiumello )
Study ID Numbers:	1160
Study First Received:	August 31, 2005
Last Updated:	September 24, 2008
ClinicalTrials.gov Identifier:	NCT00143468 History of Changes
Health Authority:	Italy: National Monitoring Centre for Clinical Trials - Ministry of Health

Keywords provided by Policlinico Hospital:

gas exchange
respiratory mechanics

Additional relevant MeSH terms:

Respiratory Tract Diseases
Lung Diseases
Respiration Disorders
Respiratory Distress Syndrome, Adult

ClinicalTrials.gov processed this record on November 25, 2009