Olmesartan Alone or in Combination With Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension (OSCAR)

This study has been completed.
Sponsor:
Information provided by:
Pfizer
ClinicalTrials.gov Identifier:
NCT00139698
First received: August 29, 2005
Last updated: July 30, 2007
Last verified: April 2007
  Purpose

Efficacy, tolerability and safety of olmesartan alone or in combination with hydrochlorothiazide in the treatment of mild to moderate essential hypertension


Condition Intervention Phase
Essential Hypertension
Drug: olmesartan alone or in combination with hydrochlorothiazide
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III, Multicenter, Open-Label, Dose-Titrating, 16-Week Study Evaluating The Efficacy, Tolerability and Safety of Olmesartan Medoxomil 20 Mg and 40 Mg Alone or in Combination With 12.5 Mg to 25 Mg of Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension

Resource links provided by NLM:


Further study details as provided by Pfizer:

Primary Outcome Measures:
  • Efficacy of olmesartan alone or in combination with hydrochlorothiazide in the treatment of mild to moderate essential hypertension

Secondary Outcome Measures:
  • Safety and tolerability of olmesartan alone or in combination with hydrochlorothiazide in the treatment of mild to moderate essential hypertension

Estimated Enrollment: 410
Study Start Date: September 2005
Estimated Study Completion Date: July 2006
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subject has mild to moderate hypertension

Exclusion Criteria:

  • History of secondary hypertension
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00139698

  Hide Study Locations
Locations
Colombia
Pfizer Investigational Site
Medellin, Antioquia, Colombia
Pfizer Investigational Site
Barranquilla, Atlantico, Colombia
Pfizer Investigational Site
Cartagena, Atlantico, Colombia
Pfizer Investigational Site
Bogota, Cundinamarca, Colombia
Pfizer Investigational Site
Cali, Valle del Cauca, Colombia
Ecuador
Pfizer Investigational Site
Escobedo, Guayas, Ecuador
Pfizer Investigational Site
Quito, Pichincha, Ecuador
Hong Kong
Pfizer Investigational Site
NT, Hong Kong
Pfizer Investigational Site
Shatin, NT, Hong Kong
Indonesia
Pfizer Investigational Site
Jakarta, Indonesia, 10430
Pfizer Investigational Site
Jakarta, Indonesia
Pfizer Investigational Site
Jakarta, Indonesia, 11420
Pfizer Investigational Site
Surabaya, Indonesia, 60286
Malaysia
Pfizer Investigational Site
Seremban, Negeri Sembilan, Malaysia, 70300
Pfizer Investigational Site
Kuching, Sarawak, Malaysia, 93586
Philippines
Pfizer Investigational Site
San Juan, Metro Manila, Philippines
Pfizer Investigational Site
Quezon, Philippines
Singapore
Pfizer Investigational Site
Singapore, Singapore, 119074
Pfizer Investigational Site
Singapore, Singapore, 169608
Taiwan
Pfizer Investigational Site
Guei-Shan Shiang, Tau-Yuan Shian, Taiwan, 333
Pfizer Investigational Site
Kaohsiung, Taiwan, 813
Pfizer Investigational Site
Taipei, Taiwan, 106
Pfizer Investigational Site
Taipei, Taiwan, 112
Thailand
Pfizer Investigational Site
Khet Rajathevee, Bangkok, Thailand, 10400
Pfizer Investigational Site
Unknown, Bangkok, Thailand
Pfizer Investigational Site
Bangkok, Thailand, 10400
Pfizer Investigational Site
Bangkok, Thailand, 10700
Pfizer Investigational Site
Chiang Mai, Thailand, 50200
Turkey
Pfizer Investigational Site
Haseki/Istanbul, 34390, Turkey
Pfizer Investigational Site
Bornova/Izmir, Turkey, 35100
Pfizer Investigational Site
Haseki/Istanbul, Turkey, 34390
Pfizer Investigational Site
Sihhiye/Ankara, Turkey, 06100
Pfizer Investigational Site
S¿hhiye/Ankara, Turkey, 06100
Sponsors and Collaborators
Pfizer
Investigators
Study Director: Pfizer CT.gov Call Center Pfizer
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00139698     History of Changes
Other Study ID Numbers: A0021002
Study First Received: August 29, 2005
Last Updated: July 30, 2007
Health Authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee

Additional relevant MeSH terms:
Hypertension
Cardiovascular Diseases
Vascular Diseases
Hydrochlorothiazide
Olmesartan
Olmesartan medoxomil
Angiotensin II Type 1 Receptor Blockers
Angiotensin Receptor Antagonists
Antihypertensive Agents
Cardiovascular Agents
Diuretics
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sodium Chloride Symporter Inhibitors
Therapeutic Uses

ClinicalTrials.gov processed this record on October 21, 2014