CCI-779 and Rituximab in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00109967
First received: May 3, 2005
Last updated: January 30, 2013
Last verified: November 2012
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Purpose
This phase II trial is studying how well giving CCI-779 together with rituximab works in treating patients with relapsed or refractory mantle cell lymphoma. Drugs used in chemotherapy, such as CCI-779, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving CCI-779 together with rituximab may kill more cancer cells
| Condition | Intervention | Phase |
|---|---|---|
|
Recurrent Mantle Cell Lymphoma |
Biological: rituximab Drug: temsirolimus |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Phase II Study of CCI-779 in Combination With Rituximab in Patients With Relapsed or Refractory Mantle Cell Lymphoma |
Resource links provided by NLM:
Further study details as provided by National Cancer Institute (NCI):
Primary Outcome Measures:
- Response rate (complete, partial, and unconfirmed) during the first 24 weeks of treatment as defined by the International Workshop criteria [ Time Frame: Not Provided ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Time to progression [ Time Frame: Not Provided ] [ Designated as safety issue: No ]
- Time to event analysis of response [ Time Frame: Not Provided ] [ Designated as safety issue: No ]
- Toxicity as measured by NCI CTCAE v.3.0 [ Time Frame: Not Provided ] [ Designated as safety issue: Yes ]
| Estimated Enrollment: | 73 |
| Study Start Date: | May 2005 |
| Primary Completion Date: | September 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Arm I
Patients receive CCI-779 IV over 30 minutes on days 1, 8, 15, and 22. Patients also receive rituximab IV on days 1, 8, 15, and 22 of course 1 and on day 1 only of courses 3, 5, 7, 9, and 11. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. After completion of course 3, patients undergo reevaluation. Patients achieving a CR or an unconfirmed CR (CRu) receive 2 additional courses of treatment for a total of 5 courses. Patients achieving a PR or stable disease continue study treatment as outlined above for up to 12 courses. Patients achieving a PR or stable disease who subsequently achieve a CR or CRu between courses 3 and 10 receive 2 additional courses of treatment.
|
Biological: rituximab
Given IV
Other Names:
Drug: temsirolimus
Given IV
Other Names:
|
Detailed Description:
PRIMARY OBJECTIVES:
I. Determine the overall response rate in patients with relapsed or refractory mantle cell lymphoma treated with CCI-779 and rituximab.
II. Determine the tolerability of this regimen in these patients. III. Determine adverse events in patients treated with this regimen.
SECONDARY OBJECTIVES:
I. Determine the time to disease progression and overall survival of patients treated with this regimen.
II. Determine the time to response and duration of response in patients treated with this regimen.
OUTLINE: Patients are stratified according to prior response to rituximab (sensitive [partial response (PR) or complete response (CR) that lasted ≥ 6 months after the last treatment with rituximab alone or in combination with chemotherapy] vs refractory [stable or progressive disease OR a PR or CR that lasted < 6 months after the last treatment with rituximab alone or in combination with chemotherapy]).
Patients receive CCI-779 IV over 30 minutes on days 1, 8, 15, and 22. Patients also receive rituximab IV on days 1, 8, 15, and 22 of course 1 and on day 1 only of courses 3, 5, 7, 9, and 11. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. After completion of course 3, patients undergo reevaluation. Patients achieving a CR or an unconfirmed CR (CRu) receive 2 additional courses of treatment for a total of 5 courses. Patients achieving a PR or stable disease continue study treatment as outlined above for up to 12 courses. Patients achieving a PR or stable disease who subsequently achieve a CR or CRu between courses 3 and 10 receive 2 additional courses of treatment.
After completion of study treatment, patients are followed every 3 months for 1 year, every 4 months for 1 year, every 6 months for 1 year, and then annually for 2 years.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
Histologically confirmed* mantle cell lymphoma (MCL)
- Relapsed, refractory, or stable disease after prior treatment
- Tumor must be cyclin D-1 by immunohistochemistry OR 11;14 translocation by fluorescent in situ hybridization or cytogenetics
Measurable disease, defined as ≥ 1 of the following:
- Unidimensionally measurable lymph node or tumor mass ≥ 2 cm by CT scan or MRI
- Splenic enlargement if spleen is palpable ≥ 3 cm below the left costal margin
- Malignant lymphocytosis if absolute lymphocytic count ≥ 5,000 AND lymphocytes confirmed to be monoclonal by flow cytometry
- No known CNS involvement (e.g., parenchymal mass or leptomeningeal involvement)
- Performance status - ECOG 0-2
- At least 3 months
- No other concurrent treatment for MCL
- Absolute neutrophil count ≥ 1,000/mm^3
- Platelet count ≥ 75,000/mm^3
- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
- Direct bilirubin < 1.5 times ULN
- AST ≤ 3 times ULN (5 times ULN if liver involvement by MCL is present)
- Creatinine ≤ 2 times ULN
- No symptomatic congestive heart failure
- No unstable angina pectoris
- No cardiac arrhythmia
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 3 months after completion of study treatment
- Cholesterol ≤ 350 mg/dL
- Fasting triglycerides < 400 mg/dL
- No known HIV positivity
- No ongoing or active infection
- No psychiatric illness or social situation that would preclude study compliance
- No other uncontrolled illness
- No other active malignancy requiring treatment OR that would preclude assessment of response to study drugs
- Prior biologic response modifiers allowed
- Prior immunotherapy allowed
- Prior high-dose therapy with stem cell support (i.e., stem cell transplantation) allowed
- No concurrent prophylactic growth factor to support neutrophils
- Prior chemotherapy allowed
- No other concurrent chemotherapy
No concurrent corticosteroids to induce an antitumor response
- Concurrent corticosteroids (≤ 10 mg/day of prednisone or equivalent) for adrenal insufficiency or acute allergic reactions allowed
- Prior radiotherapy allowed
- No prior treatment with a mTOR inhibitor
- No other concurrent investigational or commercial agents or therapies for MCL
- No other concurrent immunosuppressive therapy
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00109967
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| United States, Alabama | |
| Mobile Infirmary Medical Center | |
| Mobile, Alabama, United States, 36607 | |
| United States, Colorado | |
| The Medical Center of Aurora | |
| Aurora, Colorado, United States, 80012 | |
| Boulder Community Hospital | |
| Boulder, Colorado, United States, 80301 | |
| Penrose-Saint Francis Healthcare | |
| Colorado Springs, Colorado, United States, 80907 | |
| Colorado Cancer Research Program CCOP | |
| Denver, Colorado, United States, 80224-2522 | |
| Exempla Saint Joseph Hospital | |
| Denver, Colorado, United States, 80218 | |
| Presbyterian - Saint Lukes Medical Center - Health One | |
| Denver, Colorado, United States, 80218 | |
| Rose Medical Center | |
| Denver, Colorado, United States, 80220 | |
| Saint Anthony Central Hospital | |
| Denver, Colorado, United States, 80204 | |
| Porter Adventist Hospital | |
| Denver, Colorado, United States, 80210 | |
| Swedish Medical Center | |
| Englewood, Colorado, United States, 80110 | |
| Saint Mary's Hospital and Regional Medical Center | |
| Grand Junction, Colorado, United States, 81502 | |
| North Colorado Medical Center | |
| Greeley, Colorado, United States, 80631 | |
| Sky Ridge Medical Center | |
| Lone Tree, Colorado, United States, 80124 | |
| Longmont United Hospital | |
| Longmont, Colorado, United States, 80501 | |
| McKee Medical Center | |
| Loveland, Colorado, United States, 80539 | |
| Saint Mary Corwin Medical Center | |
| Pueblo, Colorado, United States, 81004 | |
| North Suburban Medical Center | |
| Thornton, Colorado, United States, 80229 | |
| Exempla Lutheran Medical Center | |
| Wheat Ridge, Colorado, United States, 80033 | |
| United States, Illinois | |
| Rush - Copley Medical Center | |
| Aurora, Illinois, United States, 60504 | |
| Saint Joseph Medical Center | |
| Bloomington, Illinois, United States, 61701 | |
| Graham Hospital Association | |
| Canton, Illinois, United States, 61520 | |
| Memorial Hospital | |
| Carthage, Illinois, United States, 62321 | |
| Eureka Hospital | |
| Eureka, Illinois, United States, 61530 | |
| Galesburg Clinic | |
| Galesburg, Illinois, United States, 61401 | |
| Galesburg Cottage Hospital | |
| Galesburg, Illinois, United States, 61401 | |
| Mason District Hospital | |
| Havana, Illinois, United States, 62644 | |
| Hopedale Medical Complex - Hospital | |
| Hopedale, Illinois, United States, 61747 | |
| Joliet Oncology-Hematology Associates Limited | |
| Joliet, Illinois, United States, 60435 | |
| Kewanee Hospital | |
| Kewanee, Illinois, United States, 61443 | |
| Mcdonough District Hospital | |
| Macomb, Illinois, United States, 61455 | |
| Community Cancer Center Foundation | |
| Normal, Illinois, United States, 61761 | |
| Bromenn Regional Medical Center | |
| Normal, Illinois, United States, 61761 | |
| Illinois CancerCare-Ottawa Clinic | |
| Ottawa, Illinois, United States, 61350 | |
| Ottawa Regional Hospital and Healthcare Center | |
| Ottawa, Illinois, United States, 61350 | |
| Pekin Hospital | |
| Pekin, Illinois, United States, 61554 | |
| Pekin Cancer Treatment Center | |
| Pekin, Illinois, United States, 61554 | |
| Illinois Oncology Research Association CCOP | |
| Peoria, Illinois, United States, 61615 | |
| Proctor Hospital | |
| Peoria, Illinois, United States, 61614 | |
| Methodist Medical Center of Illinois | |
| Peoria, Illinois, United States, 61603 | |
| Illinois CancerCare-Peoria | |
| Peoria, Illinois, United States, 61615 | |
| OSF Saint Francis Medical Center | |
| Peoria, Illinois, United States, 61637 | |
| Illinois Valley Hospital | |
| Peru, Illinois, United States, 61354 | |
| Perry Memorial Hospital | |
| Princeton, Illinois, United States, 61356 | |
| Saint Margaret's Hospital | |
| Spring Valley, Illinois, United States, 61362 | |
| Carle Clinic-Urbana Main | |
| Urbana, Illinois, United States, 61801 | |
| Carle Foundation dba Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| Saint Francis Hospital and Health Centers | |
| Beech Grove, Indiana, United States, 46107 | |
| Saint Anthony Memorial Health Center | |
| Michigan City, Indiana, United States, 46360 | |
| Reid Hospital and Health Care Services | |
| Richmond, Indiana, United States, 47374 | |
| United States, Iowa | |
| McFarland Clinic | |
| Ames, Iowa, United States, 50010 | |
| Saint Luke's Hospital | |
| Cedar Rapids, Iowa, United States, 52402 | |
| Cedar Rapids Oncology Association | |
| Cedar Rapids, Iowa, United States, 52403 | |
| Oncology Associates | |
| Cedar Rapids, Iowa, United States, 52403 | |
| Mercy Hospital | |
| Cedar Rapids, Iowa, United States, 52403 | |
| Medical Oncology and Hematology Associates-West Des Moines | |
| Clive, Iowa, United States, 50325 | |
| Medical Oncology and Hematology Associates-Des Moines | |
| Des Moines, Iowa, United States, 50309 | |
| Medical Oncology and Hematology Associates | |
| Des Moines, Iowa, United States, 50314 | |
| Mercy Medical Center - Des Moines | |
| Des Moines, Iowa, United States, 50314 | |
| Mercy Capitol | |
| Des Moines, Iowa, United States, 50307 | |
| Iowa Methodist Medical Center | |
| Des Moines, Iowa, United States, 50309 | |
| Iowa Lutheran Hospital | |
| Des Moines, Iowa, United States, 50316 | |
| Iowa Oncology Research Association CCOP | |
| Des Moines, Iowa, United States, 50309 | |
| Mercy Medical Center - North Iowa | |
| Mason City, Iowa, United States, 50401 | |
| Saint Luke's Regional Medical Center | |
| Sioux City, Iowa, United States, 51104 | |
| Siouxland Hematology - Oncology Associates | |
| Sioux City, Iowa, United States, 51101 | |
| Mercy Medical Center-Sioux City | |
| Sioux City, Iowa, United States, 51104 | |
| Siouxland Regional Cancer Center | |
| Sioux City, Iowa, United States, 51101-1733 | |
| United States, Kansas | |
| Hospital District Sixth of Harper County | |
| Anthony, Kansas, United States, 67003 | |
| Cancer Center of Kansas - Chanute | |
| Chanute, Kansas, United States, 66720 | |
| Cancer Center of Kansas - Dodge City | |
| Dodge City, Kansas, United States, 67801 | |
| Cancer Center of Kansas - El Dorado | |
| El Dorado, Kansas, United States, 67042 | |
| Cancer Center of Kansas - Fort Scott | |
| Fort Scott, Kansas, United States, 66701 | |
| Cancer Center of Kansas-Independence | |
| Independence, Kansas, United States, 67301 | |
| Cancer Center of Kansas-Kingman | |
| Kingman, Kansas, United States, 67068 | |
| Lawrence Memorial Hospital | |
| Lawrence, Kansas, United States, 66044 | |
| Cancer Center of Kansas - Newton | |
| Newton, Kansas, United States, 67114 | |
| Cancer Center of Kansas - Parsons | |
| Parsons, Kansas, United States, 67357 | |
| Cancer Center of Kansas - Pratt | |
| Pratt, Kansas, United States, 67124 | |
| Cancer Center of Kansas - Salina | |
| Salina, Kansas, United States, 67401 | |
| Cancer Center of Kansas - Wellington | |
| Wellington, Kansas, United States, 67152 | |
| Cancer Center of Kansas - Main Office | |
| Wichita, Kansas, United States, 67214 | |
| Cancer Center of Kansas-Wichita Medical Arts Tower | |
| Wichita, Kansas, United States, 67208 | |
| Associates In Womens Health | |
| Wichita, Kansas, United States, 67208 | |
| Wichita CCOP | |
| Wichita, Kansas, United States, 67214 | |
| Via Christi Regional Medical Center | |
| Wichita, Kansas, United States, 67214 | |
| Cancer Center of Kansas - Winfield | |
| Winfield, Kansas, United States, 67156 | |
| United States, Michigan | |
| Bixby Medical Center | |
| Adrian, Michigan, United States, 49221 | |
| Hickman Cancer Center | |
| Adrian, Michigan, United States, 49221 | |
| Saint Joseph Mercy Hospital | |
| Ann Arbor, Michigan, United States, 48106-0995 | |
| Michigan Cancer Research Consortium Community Clinical Oncology Program | |
| Ann Arbor, Michigan, United States, 48106 | |
| Oakwood Hospital | |
| Dearborn, Michigan, United States, 48123 | |
| Saint John Hospital and Medical Center | |
| Detroit, Michigan, United States, 48236 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48502 | |
| Genesys Regional Medical Center | |
| Flint, Michigan, United States, 48532 | |
| Allegiance Health | |
| Jackson, Michigan, United States, 49201 | |
| Sparrow Hospital | |
| Lansing, Michigan, United States, 48912 | |
| Saint Mary Mercy Hospital | |
| Livonia, Michigan, United States, 48154 | |
| Mercy Memorial Hospital | |
| Monroe, Michigan, United States, 48162 | |
| Community Cancer Center of Monroe | |
| Monroe, Michigan, United States, 48162 | |
| Saint Joseph Mercy Oakland | |
| Pontiac, Michigan, United States, 48341-2985 | |
| Saint Joseph Mercy Port Huron | |
| Port Huron, Michigan, United States, 48060 | |
| Saint Mary's of Michigan | |
| Saginaw, Michigan, United States, 48601 | |
| Saint John Macomb-Oakland Hospital | |
| Warren, Michigan, United States, 48093 | |
| United States, Minnesota | |
| Merit Care Clinic Bemidji | |
| Bemidji, Minnesota, United States, 56601 | |
| Fairview Ridges Hospital | |
| Burnsville, Minnesota, United States, 55337 | |
| Mercy Hospital | |
| Coon Rapids, Minnesota, United States, 55433 | |
| Miller-Dwan Hospital | |
| Duluth, Minnesota, United States, 55805 | |
| Duluth Clinic CCOP | |
| Duluth, Minnesota, United States, 55805 | |
| Saint Mary's Medical Center | |
| Duluth, Minnesota, United States, 55805 | |
| Fairview-Southdale Hospital | |
| Edina, Minnesota, United States, 55435 | |
| Unity Hospital | |
| Fridley, Minnesota, United States, 55432 | |
| Minnesota Oncology Hematology PA-Maplewood | |
| Maplewood, Minnesota, United States, 55109 | |
| Abbott-Northwestern Hospital | |
| Minneapolis, Minnesota, United States, 55407 | |
| North Memorial Medical Health Center | |
| Robbinsdale, Minnesota, United States, 55422 | |
| Mayo Clinic | |
| Rochester, Minnesota, United States, 55905 | |
| Park Nicollet Clinic - Saint Louis Park | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| Metro-Minnesota CCOP | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United Hospital | |
| Saint Paul, Minnesota, United States, 55102 | |
| Saint Francis Regional Medical Center | |
| Shakopee, Minnesota, United States, 55379 | |
| Ridgeview Medical Center | |
| Waconia, Minnesota, United States, 55387 | |
| Minnesota Oncology and Hematology PA-Woodbury | |
| Woodbury, Minnesota, United States, 55125 | |
| United States, Montana | |
| Billings Clinic | |
| Billings, Montana, United States, 59107-7000 | |
| Saint Vincent Healthcare | |
| Billings, Montana, United States, 59101 | |
| Northern Rockies Radiation Oncology Center | |
| Billings, Montana, United States, 59101 | |
| Montana Cancer Consortium CCOP | |
| Billings, Montana, United States, 59101 | |
| Hematology-Oncology Centers of the Northern Rockies PC | |
| Billings, Montana, United States, 59101 | |
| Deaconess Medical Center | |
| Billings, Montana, United States, 59107 | |
| Bozeman Deaconess Cancer Center | |
| Bozeman, Montana, United States, 59715 | |
| Bozeman Deaconess Hospital | |
| Bozeman, Montana, United States, 59715 | |
| Saint James Community Hospital and Cancer Treatment Center | |
| Butte, Montana, United States, 59701 | |
| Great Falls Clinic | |
| Great Falls, Montana, United States, 59405 | |
| Berdeaux, Donald MD (UIA Investigator) | |
| Great Falls, Montana, United States, 59405 | |
| Northern Montana Hospital | |
| Havre, Montana, United States, 59501 | |
| Saint Peter's Community Hospital | |
| Helena, Montana, United States, 59601 | |
| Kalispell Medical Oncology | |
| Kalispell, Montana, United States, 59901 | |
| Glacier Oncology PLLC | |
| Kalispell, Montana, United States, 59901 | |
| Kalispell Regional Medical Center | |
| Kalispell, Montana, United States, 59901 | |
| Guardian Oncology and Center for Wellness | |
| Missoula, Montana, United States, 59804 | |
| Saint Patrick Hospital - Community Hospital | |
| Missoula, Montana, United States, 59802 | |
| Community Medical Hospital | |
| Missoula, Montana, United States, 59801 | |
| Montana Cancer Specialists | |
| Missoula, Montana, United States, 59802 | |
| United States, North Carolina | |
| Rutherford Hospital | |
| Rutherfordton, North Carolina, United States, 28139 | |
| United States, North Dakota | |
| Saint Alexius Medical Center | |
| Bismarck, North Dakota, United States, 58501 | |
| Mid Dakota Clinic | |
| Bismarck, North Dakota, United States, 58501 | |
| Bismarck Cancer Center | |
| Bismarck, North Dakota, United States, 58501 | |
| Medcenter One Health Systems | |
| Bismarck, North Dakota, United States, 58501 | |
| MeritCare Medical Group | |
| Fargo, North Dakota, United States, 58122 | |
| Meritcare Hospital | |
| Fargo, North Dakota, United States, 58122 | |
| United States, Ohio | |
| Wood County Oncology Center | |
| Bowling Green, Ohio, United States, 43402 | |
| Samaritan North Health Center | |
| Dayton, Ohio, United States, 45415 | |
| Veteran Affairs Medical Center | |
| Dayton, Ohio, United States, 45428 | |
| Miami Valley Hospital | |
| Dayton, Ohio, United States, 45409 | |
| Good Samaritan Hospital - Dayton | |
| Dayton, Ohio, United States, 45406 | |
| Grandview Hospital | |
| Dayton, Ohio, United States, 45405 | |
| Dayton CCOP | |
| Dayton, Ohio, United States, 45429 | |
| Hematology Oncology Center Incorporated | |
| Elyria, Ohio, United States, 44035 | |
| Blanchard Valley Hospital | |
| Findlay, Ohio, United States, 45840 | |
| Atrium Medical Center-Middletown Regional Hospital | |
| Franklin, Ohio, United States, 45005-1066 | |
| Fremont Memorial Hospital | |
| Fremont, Ohio, United States, 43420 | |
| Wayne Hospital | |
| Greenville, Ohio, United States, 45331 | |
| Cole, Sharon, K. M.D. (UIA Investigator) | |
| Kenton, Ohio, United States, 43326 | |
| Kettering Medical Center | |
| Kettering, Ohio, United States, 45429 | |
| Lima Memorial Hospital | |
| Lima, Ohio, United States, 45804 | |
| Saint Luke's Hospital | |
| Maumee, Ohio, United States, 43537 | |
| Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | |
| Maumee, Ohio, United States, 43537 | |
| Northwest Ohio Oncology Center | |
| Maumee, Ohio, United States, 43537-1839 | |
| Bayview Oncology Associates | |
| Oregon, Ohio, United States, 43616 | |
| Saint Charles Hospital | |
| Oregon, Ohio, United States, 43616 | |
| North Coast Cancer Care | |
| Sandusky, Ohio, United States, 44870 | |
| Firelands Regional Medical Center | |
| Sandusky, Ohio, United States, 44870 | |
| Flower Memorial Hospital | |
| Sylvania, Ohio, United States, 43560 | |
| Mercy Hospital of Tiffin | |
| Tiffin, Ohio, United States, 44883 | |
| University of Toledo | |
| Toledo, Ohio, United States, 43614 | |
| Stark, Michael, Edward. M.D. (UIA Investigator) | |
| Toledo, Ohio, United States, 43623 | |
| Toledo Clinic | |
| Toledo, Ohio, United States, 43623 | |
| Mercy Cancer Center at Saint Anne Mercy Hospital | |
| Toledo, Ohio, United States, 43623 | |
| Saint Vincent Mercy Medical Center | |
| Toledo, Ohio, United States, 43608 | |
| Toledo Community Hospital Oncology Program CCOP | |
| Toledo, Ohio, United States, 43617 | |
| The Toledo Hospital | |
| Toledo, Ohio, United States, 43606 | |
| Upper Valley Medical Center | |
| Troy, Ohio, United States, 45373 | |
| Fulton County Health Center | |
| Wauseon, Ohio, United States, 43567 | |
| Clinton Memorial Hospital | |
| Wilmington, Ohio, United States, 45177 | |
| Greene Memorial Hospital | |
| Xenia, Ohio, United States, 45385 | |
| United States, Pennsylvania | |
| Lehigh Valley Hospital | |
| Allentown, Pennsylvania, United States, 18105 | |
| Geisinger Medical Center | |
| Danville, Pennsylvania, United States, 17822-2001 | |
| Geisinger Medical Group | |
| State College, Pennsylvania, United States, 16801 | |
| Geisinger Wyoming Valley | |
| Wilkes-Barre, Pennsylvania, United States, 18711 | |
| United States, South Carolina | |
| AnMed Health Hospital | |
| Anderson, South Carolina, United States, 29621 | |
| Upstate Carolina CCOP | |
| Spartanburg, South Carolina, United States, 29303 | |
| Spartanburg Regional Medical Center | |
| Spartanburg, South Carolina, United States, 29303 | |
| United States, South Dakota | |
| Avera Cancer Institute | |
| Sioux Falls, South Dakota, United States, 57105 | |
| Avera McKennan Hospital and University Health Center | |
| Sioux Falls, South Dakota, United States, 57105 | |
| United States, Virginia | |
| Fredericksburg Oncology Inc | |
| Fredericksburg, Virginia, United States, 22401 | |
| United States, Wyoming | |
| Welch Cancer Center | |
| Sheridan, Wyoming, United States, 82801 | |
Sponsors and Collaborators
Investigators
| Principal Investigator: | Stephen Ansell | North Central Cancer Treatment Group |
More Information
No publications provided by National Cancer Institute (NCI)
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00109967 History of Changes |
| Other Study ID Numbers: | NCI-2009-00644, N038H, U10CA025224, CDR0000425334 |
| Study First Received: | May 3, 2005 |
| Last Updated: | January 30, 2013 |
| Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
|
Lymphoma Lymphoma, Non-Hodgkin Lymphoma, Mantle-Cell Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Antibodies, Monoclonal Sirolimus Everolimus |
Rituximab Immunologic Factors Physiological Effects of Drugs Pharmacologic Actions Antibiotics, Antineoplastic Antineoplastic Agents Therapeutic Uses Antifungal Agents Anti-Infective Agents Immunosuppressive Agents Anti-Bacterial Agents Antirheumatic Agents |
ClinicalTrials.gov processed this record on May 16, 2013