Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00096278
First received: November 9, 2004
Last updated: January 2, 2013
Last verified: January 2013
  Purpose

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as bevacizumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Bevacizumab may also stop the growth of tumor cells by stopping blood flow to the tumor. Giving chemotherapy together with bevacizumab may kill more tumor cells. It is not yet known whether treatment with oxaliplatin, leucovorin, and fluorouracil is more effective with or without bevacizumab in treating patients who have undergone surgery for colon cancer.

PURPOSE: This randomized phase III trial is studying giving oxaliplatin, leucovorin, and fluorouracil together with bevacizumab to see how well it works compared to oxaliplatin, leucovorin, and fluorouracil alone in treating patients who have undergone surgery for stage II or stage III colon cancer.


Condition Intervention Phase
Colorectal Cancer
Biological: bevacizumab
Drug: 5-fluorouracil
Drug: leucovorin
Drug: oxaliplatin
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Disease-free Survival [ Time Frame: 3 years ] [ Designated as safety issue: No ]
    Where events are defined as recurrence, second primary cancer, or death from any cause


Secondary Outcome Measures:
  • Survival as Assessed by Death From Any Cause [ Time Frame: Every 6 months for 4 years and then every 12 months until death from any cause ] [ Designated as safety issue: No ]
  • Proteinuria After Completion of Bevacizumab [ Time Frame: For Groups 1 and 2 at the end of every 3 cycles of chemotherapy plus or minus bevacizumab; for Group 2 patients, every 6 weeks for 6 months. If UPC ratio is greater than or equal to 1.0 at the end of therapy then test every 3 months for 12 months ] [ Designated as safety issue: Yes ]
  • Proteinuria With Clinical Sequelae [ Time Frame: For Groups 1 and 2 at the end of every 3 cycles of chemotherapy plus or minus bevacizumab; for Group 2 patients, every 6 weeks for 6 months. If UPC ratio is greater than or equal to 1.0 at the end of therapy then test every 3 months for 12 months ] [ Designated as safety issue: Yes ]
  • The Risk Factors for Development of Proteinuria [ Time Frame: For Groups 1 and 2 at the end of every 3 cycles of chemotherapy plus or minus bevacizumab; for Group 2 patients, every 6 weeks for 6 months. If UPC ratio is greater than or equal to 1.0 at the end of therapy then test every 3 months for 12 months ] [ Designated as safety issue: Yes ]
  • As Measured by Blood Pressure and Antihypertensive Medication Hypertension [ Time Frame: Group 2, every 3 months for one year post treatment ] [ Designated as safety issue: Yes ]
  • Delayed Vascular Events Such as Myocardial Infarction, Central Nervous System (CNS) Ischemia, and Thrombosis in Patients Receiving Chemotherapy + Bevacizumab [ Time Frame: Events measured regularly during chemotherapy and bevacizumab therapy ] [ Designated as safety issue: Yes ]
  • Ovarian Function in Premenopausal Women as Measured by Serum Ovarian Function Test [ Time Frame: Group 2: Measured pre-therapy and then every 6 months for 2 years following randomization ] [ Designated as safety issue: Yes ]
  • Bevacizumab Immunogenicity and Post-treatment Serum Levels of Bevacizumab in Patients Receiving Bevacizumab [ Time Frame: Group 2: Pre-therapy, every 2 weeks during chemotherapy/bevacizumab therapy, every 6 weeks during bevacizumab therapy and at 3 and 6 months after completion of bevacizumab therapy ] [ Designated as safety issue: Yes ]

Enrollment: 2710
Study Start Date: September 2004
Estimated Study Completion Date: March 2014
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm 1: Oxaliplatin + Leucovorin + 5-Fluorouracil
Oxaliplatin + Leucovorin + 5-Fluorouracil
Drug: 5-fluorouracil
5-FU 400 mg/m2 IV bolus Day 1 every 14 days for 12 cycles and 5-FU 2400 mg/m2 by continuous IV infusion over 46 hours (Day 1 and Day 2) every 14 days for 12 cycles
Drug: leucovorin
leucovorin 400 mg/m2 IV Day 1 every 14 days for 12 cycles
Drug: oxaliplatin
Oxaliplatin 85 mg/m2 IV day 1 every 14 days for 12 cycles
Experimental: Arm 2: Oxaliplatin + Leucovorin + 5-Fluorouracil + Bevacizumab
Oxaliplatin + Leucovorin + 5-Fluorouracil + Bevacizumab
Biological: bevacizumab
bevacizumab 5 mg/kg IV day 1 every 14 days for 1 year
Drug: 5-fluorouracil
5-FU 400 mg/m2 IV bolus Day 1 every 14 days for 12 cycles and 5-FU 2400 mg/m2 by continuous IV infusion over 46 hours (Day 1 and Day 2) every 14 days for 12 cycles
Drug: leucovorin
leucovorin 400 mg/m2 IV Day 1 every 14 days for 12 cycles
Drug: oxaliplatin
Oxaliplatin 85 mg/m2 IV day 1 every 14 days for 12 cycles

Detailed Description:

OBJECTIVES:

Primary

  • Compare disease-free survival of patients with resected stage II or III adenocarcinoma of the colon treated with adjuvant chemotherapy comprising fluorouracil, leucovorin calcium, and oxaliplatin with vs without bevacizumab.

Secondary

  • Compare overall survival of patients treated with these regimens.

Tertiary

  • Determine the persistence of proteinuria after completion of bevacizumab in patients treated with bevacizumab.
  • Correlate the development of proteinuria with clinical sequelae in patients treated with bevacizumab.
  • Determine risk factors for development of proteinuria in patients treated with bevacizumab.
  • Determine the effect of discontinuing bevacizumab on hypertension in these patients.
  • Determine the incidence of delayed vascular events (e.g., myocardial infarction, Central Nervous System (CNS) ischemia, and thrombosis) in patients treated with chemotherapy in combination with bevacizumab.
  • Determine the effect of this drug on ovarian function in premenopausal women.
  • Determine the incidence rate of immunogenicity and serum levels of bevacizumab in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center and number of positive lymph nodes (0 vs 1-3 vs > 3). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive adjuvant chemotherapy comprising concurrent oxaliplatin and leucovorin calcium IV over 2 hours on day 1. Patients also receive adjuvant fluorouracil IV over 2-4 minutes on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for 12 courses in the absence of disease progression or unacceptable toxicity.
  • Arm II: Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive adjuvant oxaliplatin, leucovorin calcium, and fluorouracil as in arm I. Treatment repeats every 14 days for 12 courses in the absence of disease progression or unacceptable toxicity. After completion of adjuvant chemotherapy, patients continue to receive bevacizumab alone every 14 days for 6 months in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 2,632 patients (1,316 per treatment arm) will be accrued for this study within 2.5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the colon, meeting 1 of the following stage criteria:

    • Stage II disease (T3 or 4, N0, M0)
    • Stage III disease (any T, N1 or 2, M0)
  • No rectal tumors

    • Distal extent of tumor ≥ 12 cm from the anal verge by endoscopy or surgical examination
  • T4 tumors involving an adjacent structure (e.g., bladder, small intestine, or ovary) by direct extension from the primary tumor are eligible provided the following criteria are met:

    • All or a portion of the adjacent structure was removed en bloc with the primary tumor
    • All grossly visible tumor was completely resected (i.e., curative resection) in the opinion of the surgeon
    • Margins of the resected specimen not involved with malignant cells by pathology
    • Not planning local radiotherapy
  • En bloc complete gross resection of tumor by open laparotomy or laparoscopically-assisted colectomy within the past 29-50 days

    • Two-stage surgical procedure allowed (i.e., decompressive colostomy followed by definitive surgical resection)
  • Patients with > 1 synchronous primary colon tumor are eligible

    • Disease staging based on more advanced primary tumor
  • No isolated, distant, or non-contiguous intra-abdominal metastases, even if resected

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • Eastern Cooperative Oncology Group (ECOG) 0-1

Life expectancy

  • At least 5 years

Hematopoietic

  • Absolute granulocyte count ≥ 1,500/mm^3 (unless it represents an ethnic or racial variation of normal)
  • Postoperative platelet count ≥ 100,000/mm^3
  • No significant bleeding unrelated to the primary colon tumor within the past 6 months

Hepatic

  • Bilirubin ≤ upper limit of normal (ULN) (unless due to slow conjugation of bilirubin caused by Gilbert's disease or a similar syndrome)
  • Alkaline phosphatase < 2.5 times ULN
  • Aspartate Aminotransferase (AST) < 1.5 times ULN

    • If AST > normal, serologic testing for hepatitis B and C is required and the results must be negative
  • No Prothrombin Time and International Normalized Ratio (PT/INR) > 1.5 unless patient is on full-dose anticoagulants AND the following criteria are met:

    • INR 2-3 on a stable dose of warfarin
    • No active bleeding
    • No pathological condition associated with a high risk of bleeding
  • No hepatic disease that would preclude study participation
  • No history of viral hepatitis or other chronic liver disease

Renal

  • Serum creatinine ≤ 1.5 times ULN
  • Urine protein/creatinine ratio < 1.0 OR
  • < 1 g of protein on 24-hour urine collection
  • No renal disease that would preclude study participation

Cardiovascular

  • No uncontrolled blood pressure, defined as > 150/90 mm Hg
  • No cardiovascular disease that would preclude study participation, including any of the following:

    • New York Heart Association class III or IV myocardial disease
    • Myocardial infarction within the past 12 months
    • Unstable angina within the past 12 months
    • Symptomatic arrhythmia
  • No history of transient ischemic attack or cerebrovascular accident
  • No arterial thrombotic event within the past 12 months
  • No symptomatic peripheral vascular disease

Other

  • No other malignancy within the past 5 years except effectively treated squamous cell or basal cell skin cancer, melanoma in situ, carcinoma in situ of the cervix, or carcinoma in situ of the colon or rectum

    • Must be at low risk of recurrence from any prior malignancy
  • No serious or non-healing wound, skin ulcer, or bone fracture
  • No active gastroduodenal ulcer by endoscopy
  • No clinically significant peripheral neuropathy (i.e., neurosensory or neuromotor toxicity ≥ grade 2)
  • No significant traumatic injury within the past 4 weeks
  • No other nonmalignant systemic disease that would preclude study participation
  • No psychiatric or addictive disorder or other condition that would preclude study participation
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception

    • Patients randomized to receive bevacizumab must use effective contraception during and for 3 months after study treatment

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • No concurrent prophylactic growth factors
  • No concurrent biological response modifiers

Chemotherapy

  • Not specified

Endocrine therapy

  • Not specified

Radiotherapy

  • See Disease Characteristics
  • No prior radiotherapy for this malignancy
  • No concurrent radiotherapy for this malignancy

Surgery

  • See Disease Characteristics
  • Recovered from prior surgery
  • More than 4 weeks since prior major surgery or open biopsy
  • More than 7 days since prior core biopsy or other minor surgery (except placement of a vascular access device)
  • No concurrent or anticipated concurrent major surgery

Other

  • No prior systemic therapy for this malignancy
  • No concurrent halogenated antiviral agents (e.g., sorivudine)
  • No other concurrent investigational drugs
  • No other concurrent antineoplastic agents
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00096278

  Hide Study Locations
Locations
United States, Alabama
Northeast Alabama Regional Medical Center
Anniston, Alabama, United States, 36202
Huntsville Hospital
Huntsville, Alabama, United States, 35801
MBCCOP - Gulf Coast
Mobile, Alabama, United States, 36604
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, United States, 36688
East Alabama Medical Center
Opelika, Alabama, United States, 36801-5452
United States, Alaska
Cancer Center at Providence Alaska Medical Center
Anchorage, Alaska, United States, 99519-6604
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, United States, 99701
United States, California
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States, 94704
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States, 91505
Peninsula Medical Center
Burlingame, California, United States, 94010
Cancer Care Center at John Muir Health - Concord Campus
Concord, California, United States, 94524-4110
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010-3000
North Bay Cancer Center
Fairfield, California, United States, 94533
Kaiser Permanente - Fremont
Fremont, California, United States, 94538
California Cancer Care, Incorporated
Greenbrae, California, United States, 94904
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, United States, 94904
Sutter Health - Western Division Cancer Research Group
Greenbrae, California, United States, 94904
Kaiser Permanente Medical Center - Hayward
Hayward, California, United States, 94545
Saint Rose Hospital
Hayward, California, United States, 94545
Ida M. and Cecil H. Green Cancer Center at Scripps Clinic
La Jolla, California, United States, 92037
Veterans Affairs Medical Center - Loma Linda (Pettis)
Loma Linda, California, United States, 92357
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States, 90089-9181
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center
Los Angeles, California, United States, 90033
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States, 94609
CCOP - Bay Area Tumor Institute
Oakland, California, United States, 94609
Kaiser Permanente Medical Center - Oakland
Oakland, California, United States, 94611
Highland General Hospital at St. George's University School of Medicine
Oakland, California, United States, 94602
Valley Care Medical Center
Pleasanton, California, United States, 94588
Mercy Regional Cancer Center at Mercy Medical Center
Redding, California, United States, 96049
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, United States, 94063
Kaiser Permanente Medical Center - Richmond
Richmond, California, United States, 94801
Kaiser Permanente Medical Center - Roseville
Roseville, California, United States, 95661
Sutter Cancer Center at Roseville Medical Center
Roseville, California, United States, 95661
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, United States, 95825
South Sacramento Kaiser-Permanente Medical Center
Sacramento, California, United States, 95823
Mercy General Hospital
Sacramento, California, United States, 95819
Sutter Cancer Center
Sacramento, California, United States, 95816
Salinas Valley Memorial Hospital
Salinas, California, United States, 93901
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, United States, 94115
California Pacific Medical Center - California Campus
San Francisco, California, United States, 94118
Kaiser Permanente Medical Center - Santa Teresa
San Jose, California, United States, 95119
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States, 94806
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, United States, 95051
Kaiser Permanente Medical Center - Santa Rosa
Santa Rosa, California, United States, 95403
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, United States, 95405
Kaiser Permanente Medical Center - South San Francisco
South San Francisco, California, United States, 94080
Kaiser Permanente Medical Facility - Stockton
Stockton, California, United States, 95210
Camino Medical Group - Treatment Center
Sunnyvale, California, United States, 94086
Sutter Solano Medical Center
Vallejo, California, United States, 94589
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, United States, 94589
John Muir/Mt. Diablo Comprehensive Cancer Center
Walnut Creek, California, United States, 94598
Kaiser Permanente Medical Center - Walnut Creek
Walnut Creek, California, United States, 94596
United States, Colorado
Aurora Presbyterian Hospital
Aurora, Colorado, United States, 80012
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Aurora, Colorado, United States, 80045
Boulder Community Hospital
Boulder, Colorado, United States, 80301-9019
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States, 80933
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States, 80224-2522
St. Joseph Hospital
Denver, Colorado, United States, 80218
Rose Medical Center
Denver, Colorado, United States, 80220
Presbyterian - St. Luke's Medical Center
Denver, Colorado, United States, 80218
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Swedish Medical Center
Englewood, Colorado, United States, 80110
Front Range Cancer Specialists
Fort Collins, Colorado, United States, 80524
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, United States, 81502
Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, United States, 80502
Montrose Memorial Hospital Cancer Center
Montrose, Colorado, United States, 81401
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States, 81004
North Suburban Medical Center
Thornton, Colorado, United States, 80229
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
Helen and Harry Gray Cancer Center at Hartford Hospital
Hartford, Connecticut, United States, 06102-5037
Carl and Dorothy Bennett Cancer Center at Stamford Hospital
Stamford, Connecticut, United States, 06904
United States, District of Columbia
Howard University Cancer Center at Howard University Hospital
Washington, District of Columbia, United States, 20060
Sibley Memorial Hospital
Washington, District of Columbia, United States, 20016
United States, Florida
Halifax Medical Center
Daytona Beach, Florida, United States, 32115
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Broward General Medical Center Cancer Center
Ft. Lauderdale, Florida, United States, 33316
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
St. Vincent's Medical Center
Jacksonville, Florida, United States, 32204
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States, 33458
Lakeland Regional Cancer Center at Lakeland Regional Medical Center
Lakeland, Florida, United States, 33805
Watson Clinic, LLC
Lakeland, Florida, United States, 33804-5000
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States, 33136
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Florida Oncology Associates
Orange Park, Florida, United States, 32073
M.D. Anderson Cancer Center Orlando
Orlando, Florida, United States, 32806
Florida Cancer Specialists - Sarasota Downtown
Sarasota, Florida, United States, 34231
Space Coast Medical Associates
Titusville, Florida, United States, 32796
United States, Georgia
Phoebe Cancer Center at Phoebe Putney Memorial Hospital
Albany, Georgia, United States, 31701
Northeast Georgia Cancer Care, LLC
Athens, Georgia, United States, 30607
CCOP - Atlanta Regional
Atlanta, Georgia, United States, 30342
Northside Hospital Cancer Center
Atlanta, Georgia, United States, 30342-1611
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, United States, 30342-1701
MBCCOP-Medical College of Georgia Cancer Center
Augusta, Georgia, United States, 30912
Veterans Affairs Medical Center - Augusta
Augusta, Georgia, United States, 30904
WellStar Cobb Hospital
Austell, Georgia, United States, 30106
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur, Georgia, United States, 30033
Gwinnett Medical Center
Lawrenceville, Georgia, United States, 30045
Medical Center of Central Georgia
Macon, Georgia, United States, 31208
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, United States, 30060
Southern Regional Medical Center
Riverdale, Georgia, United States, 30274-2600
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States, 31403-3089
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, United States, 31405
United States, Idaho
Hematology Oncology Associates of Eastern Idaho
Idaho Falls, Idaho, United States, 83404
United States, Illinois
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, United States, 62002
Rush-Copley Cancer Care Center
Aurora, Illinois, United States, 60507
Creticos Cancer Center at Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
Veterans Affairs Medical Center - Chicago Westside Hospital
Chicago, Illinois, United States, 60612
University of Illinois Cancer Center
Chicago, Illinois, United States, 60612-7243
Louis A. Weiss Memorial Hospital
Chicago, Illinois, United States, 60640
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States, 62526
Sherman Hospital
Elgin, Illinois, United States, 60120
St. Francis Hospital
Evanston, Illinois, United States, 60202
Delnor Community Hospital - Geneva
Geneva, Illinois, United States, 60134
Ingalls Cancer Care Center at Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States, 60521
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, United States, 60435
Provena St. Mary's Wasser Regional Cancer Center - Kankakee
Kankakee, Illinois, United States, 60901
La Grange Memorial Hospital
La Grange, Illinois, United States, 60525
Good Samaritan Regional Health Center
Mt. Vernon, Illinois, United States, 62864
Northwest Medical Specialist, PC
Niles, Illinois, United States, 60714
Mid-Illinois Hematology-Oncology Associates at Community Cancer Center
Normal, Illinois, United States, 61761
West Suburban Hospital Medical Center
Oak Park, Illinois, United States, 60302
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
Olympia Fields, Illinois, United States, 60461
Swedish-American Regional Cancer Center
Rockford, Illinois, United States, 61104-2315
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, United States, 61801
CCOP - Carle Cancer Center
Urbana, Illinois, United States, 61801
United States, Indiana
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, United States, 46107
Elkhart General Hospital
Elkhart, Indiana, United States, 46515
Fort Wayne Medical Oncology and Hematology
Fort Wayne, Indiana, United States, 46815
Center for Cancer Care at Goshen Health System
Goshen, Indiana, United States, 46527
Methodist Cancer Center at Clarian Health
Indianapolis, Indiana, United States, 46202
Howard Community Hospital at Howard Regional Health System
Kokomo, Indiana, United States, 46904
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, United States, 46350
Saint Anthony Memorial Health Centers
Michigan City, Indiana, United States, 46360
Community Hospital
Munster, Indiana, United States, 46321
Reid Hospital & Health Care Services, Incorporated
Richmond, Indiana, United States, 47374
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, United States, 46601
Saint Joseph Regional Medical Center
South Bend, Indiana, United States, 46617
Memorial Hospital of South Bend
South Bend, Indiana, United States, 46601
United States, Iowa
McFarland Clinic, PC
Ames, Iowa, United States, 50010
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, United States, 52722
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Iowa Blood and Cancer Care
Cedar Rapids, Iowa, United States, 52402
St. Luke's Hospital
Cedar Rapids, Iowa, United States, 52402
Heartland Oncology & Hematology
Council Bluffs, Iowa, United States, 51503
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States, 52803
Mercy Capitol Hospital
Des Moines, Iowa, United States, 50307
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316-2301
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, United States, 50314
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, United States, 52242
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, United States, 50401
Ottumwa Regional Health Center Cancer Center
Ottumwa, Iowa, United States, 52501
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
Waterloo, Iowa, United States, 50702
Covenant Cancer Treatment Center
Waterloo, Iowa, United States, 50702
Medical Oncology and Hematology Associates - West Des Moines
West Des Moines, Iowa, United States, 50266
United States, Kansas
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, United States, 66720
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, United States, 67801
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, United States, 67042
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, United States, 67068
Southwest Medical Center
Liberal, Kansas, United States, 67901
Cancer Center of Kansas, PA - Newton
Newton, Kansas, United States, 67114
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, United States, 67357
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, United States, 67124
Cancer Center of Kansas, PA - Salina
Salina, Kansas, United States, 67042
Stormont-Vail Cancer Center
Topeka, Kansas, United States, 66604
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, United States, 67152
CCOP - Wichita
Wichita, Kansas, United States, 67214
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States, 67214
Associates in Womens Health, PA - North Review
Wichita, Kansas, United States, 67203
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, United States, 67208
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, United States, 67214
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, United States, 67156
United States, Kentucky
Cancer Resource Center at King's Daughters Medical Center
Ashland, Kentucky, United States, 41101
Central Baptist Hospital
Lexington, Kentucky, United States, 40503-9985
Baptist Hospital East - Louisville
Louisville, Kentucky, United States, 40207
Louisville Oncology at Norton Cancer Center
Louisville, Kentucky, United States, 40202
United States, Louisiana
Ochsner Clinic of Baton Rouge
Baton Rouge, Louisiana, United States, 708169990
Pennington Cancer Center at Baton Rouge General
Baton Rouge, Louisiana, United States, 70806
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, United States, 70809
Terrebonne General Medical Center
Houma, Louisiana, United States, 70360
Louisiana State University Health Sciences Center - Monroe
Monroe, Louisiana, United States, 71210
CCOP - Ochsner
New Orleans, Louisiana, United States, 70121
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, United States, 71130-3932
Christus Schumpert Cancer Treatment Center
Shreveport, Louisiana, United States, 71101
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, United States, 71101
United States, Maine
CancerCare of Maine at Eastern Maine Medial Center
Bangor, Maine, United States, 04401
St. Mary's Regional Center for Cancer and Blood Disorders
Lewiston, Maine, United States, 04240
Mercy Hospital of Portland
Portland, Maine, United States, 04101
Maine Center for Cancer Medicine and Blood Disorders - Scarborough
Scarborough, Maine, United States, 04074
United States, Maryland
DeCesaris Cancer Institute at Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
Baltimore, Maryland, United States, 21237
Suburban Hospital
Bethesda, Maryland, United States, 20814
Frederick Memorial Hospital Regional Cancer Therapy Center
Frederick, Maryland, United States, 21701
Peninsula Regional Medical Center
Salisbury, Maryland, United States, 21801
Holy Cross Hospital
Silver Spring, Maryland, United States, 20910
Cancer Institute at St. Joseph Medical Center
Towson, Maryland, United States, 21204
United States, Massachusetts
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, United States, 02118
Tufts-NEMC Cancer Center
Boston, Massachusetts, United States, 02111
Caritas St. Elizabeth's Medical Center
Boston, Massachusetts, United States, 02135-2997
Hudner Oncology Center at Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
Caritas Norwood Hospital
Norwood, Massachusetts, United States, 02062
NSMC Cancer Center - Peabody
Peabody, Massachusetts, United States, 01960
Jordan Hospital Club Cancer Center
Plymouth, Massachusetts, United States, 02360
South Shore Hospital
South Weymouth, Massachusetts, United States, 02190
United States, Michigan
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, United States, 49221
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, United States, 48106
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106-0995
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, United States, 49017
Mecosta County Medical Center
Big Rapids, Michigan, United States, 49307
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, United States, 48123-2500
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, United States, 48202
Green Bay Oncology, Limited - Escanaba
Escanaba, Michigan, United States, 49431
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Hurley Medical Center
Flint, Michigan, United States, 48503
Metropolitan Hospital
Grand Rapids, Michigan, United States, 49506
Spectrum Health Hospital - Butterworth Campus
Grand Rapids, Michigan, United States, 49503
Lacks Cancer Center at Saint Mary's Mercy Medical Center
Grand Rapids, Michigan, United States, 49503
CCOP - Grand Rapids
Grand Rapids, Michigan, United States, 49503
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, United States, 48236
Holland Community Hospital
Holland, Michigan, United States, 49423
Green Bay Oncology, Limited - Iron Mountain
Iron Mountain, Michigan, United States, 49801
Foote Hospital
Jackson, Michigan, United States, 49201
Haematology-Oncology Associates of Ohio and Michigan, PC
Lambertville, Michigan, United States, 48144
Sparrow Regional Cancer Center
Lansing, Michigan, United States, 48909
Breslin Cancer Center at Ingham Regional Medical Center
Lansing, Michigan, United States, 48910
Upper Michigan Cancer Center at Marquette General Hospital
Marquette, Michigan, United States, 49855
Mercy Memorial Hospital System
Monroe, Michigan, United States, 48162
Community Cancer Center of Monroe
Monroe, Michigan, United States, 48162
Hackley Hospital
Muskegon, Michigan, United States, 49443
Northern Michigan Hospital
Petoskey, Michigan, United States, 49770
St. Joseph Mercy Oakland
Pontiac, Michigan, United States, 48341-2985
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, United States, 48060
Seton Cancer Institute - Saginaw
Saginaw, Michigan, United States, 48601
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
St. Joseph, Michigan, United States, 49085
Munson Medical Center
Traverse City, Michigan, United States, 49684
St. John Macomb Hospital
Warren, Michigan, United States, 48093
United States, Minnesota
MeritCare Clinic - Bemidji
Bemidji, Minnesota, United States, 56601
Fairview Ridges Hospital
Burnsville, Minnesota, United States, 55337
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Cancer Care Center at St. Luke's Hospital
Duluth, Minnesota, United States, 55805
CCOP - Duluth
Duluth, Minnesota, United States, 55805
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, United States, 55432
Minnesota Oncology Hematology, PA at Maplewood Cancer Center
Maplewood, Minnesota, United States, 55109
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Chippewa County - Montevideo Hospital
Montevideo, Minnesota, United States, 56265
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, United States, 55422-2900
Coborn Cancer Center
Saint Cloud, Minnesota, United States, 56303
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
CentraCare Clinic - River Campus
St. Cloud, Minnesota, United States, 56303
Park Nicollet Health Services
St. Louis Park, Minnesota, United States, 55416
United Hospital
St. Paul, Minnesota, United States, 55102
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Minnesota Oncology Hematology, PA - Woodbury
Woodbury, Minnesota, United States, 55125
United States, Mississippi
Hattiesburg Clinic, PA at Forrest General
Hattiesburg, Mississippi, United States, 39401
Hematology & Oncology Clinic
Hattiesburg, Mississippi, United States, 39402
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, United States, 39581
United States, Missouri
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Cape Girardeau, Missouri, United States, 63701
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63701
Saint Luke's Hospital
Chesterfield, Missouri, United States, 63017
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, United States, 65203
St. John's Regional Medical Center
Joplin, Missouri, United States, 64804
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, United States, 64804
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
Saint Louis University Cancer Center
Saint Louis, Missouri, United States, 63110
Arch Medical Services, Incorporated at Center for Cancer Care Research
Saint Louis, Missouri, United States, 63141
David C. Pratt Cancer Center at St. John's Mercy
Saint Louis, Missouri, United States, 63141
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, United States, 65807
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, United States, 65802
CCOP - St. Louis-Cape Girardeau
St. Louis, Missouri, United States, 63141
Missouri Baptist Cancer Center
St. Louis, Missouri, United States, 63131
United States, Montana
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, United States, 59101
Deaconess Billings Clinic - Downtown
Billings, Montana, United States, 59107-7000
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
St. Vincent Healthcare
Billings, Montana, United States, 59101
Northern Rockies Radiation Oncology Center
Billings, Montana, United States, 59101
Bozeman Deaconess Hospital
Bozeman, Montana, United States, 59715
St. James Community Hospital
Butte, Montana, United States, 59701
Great Falls Clinic
Great Falls, Montana, United States, 59405
Big Sky Oncology
Great Falls, Montana, United States, 59405
Sletten Regional Cancer Institute at Benefis Healthcare
Great Falls, Montana, United States, 59405
St. Peter's Hospital
Helena, Montana, United States, 59601
Kalispell Medical Oncology
Kalispell, Montana, United States, 59901
Glacier Oncology, PLLC
Kalispell, Montana, United States, 59901
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, United States, 59807
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, United States, 59807-7877
Community Medical Center
Missoula, Montana, United States, 59801
United States, Nebraska
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, United States, 68848-1990
Cancer Resource Center - Lincoln
Lincoln, Nebraska, United States, 68510
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, United States, 68106
Methodist Cancer Center at Methodist Hospital - Omaha
Omaha, Nebraska, United States, 68114
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Creighton University Medical Center
Omaha, Nebraska, United States, 68131-2197
United States, Nevada
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States, 89102
Washoe Cancer Services at Washoe Medical Center - Reno
Reno, Nevada, United States, 89502
United States, New Hampshire
Exeter Hospital Center for Cancer Care
Exeter, New Hampshire, United States, 03833
New Hampshire Oncology-Hematology, PA - Hooksett
Hooksett, New Hampshire, United States, 03106
Lakes Region General Hospital
Laconia, New Hampshire, United States, 03246
Elliot Regional Cancer Center at Elliot Hospital
Manchester, New Hampshire, United States, 03103
United States, New Jersey
Ocean Medical Center at Meridian Health
Brick, New Jersey, United States, 08724
St. Barnabas Medical Center Cancer Center
Livingston, New Jersey, United States, 07039
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Marlton, New Jersey, United States, 08053
Mountainside Hospital Cancer Center
Montclair, New Jersey, United States, 07042
Carol G. Simon Cancer Center at Morristown Memorial Hospital
Morristown, New Jersey, United States, 07962
Jersey Shore Cancer Center at Jersey Shore University Medical Center
Neptune, New Jersey, United States, 07754-0397
Saint Peter's University Hospital
New Brunswick, New Jersey, United States, 08903
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States, 08903
Warren Hospital
Phillipsburg, New Jersey, United States, 08865
AtlantiCare Regional Medical Center
Pomona, New Jersey, United States, 08240
Shore Memorial Hospital - Somers Point
Somers Point, New Jersey, United States, 08244
Somerset Medical Center
Somerville, New Jersey, United States, 08876
Overlook Hospital
Summit, New Jersey, United States, 07902
Fox Chase Cancer Center at St. Francis Medical Center
Trenton, New Jersey, United States, 08629
Capital Health System Regional Cancer Center
Trenton, New Jersey, United States, 08618
Fox Chase Virtua Health Cancer Program at Virtua West Jersey
Voorhees, New Jersey, United States, 08043
Underwood Memorial Hospital
Woodbury, New Jersey, United States, 08096
United States, New Mexico
Hematology Oncology Associates, PC
Albuquerque, New Mexico, United States, 87106
Lovelace Medical Center
Albuquerque, New Mexico, United States, 87108
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, United States, 87131-5636
St. Vincent Regional Cancer Center
Santa Fe, New Mexico, United States, 87505
New Mexico Cancer Care Associates
Santa Fe, New Mexico, United States, 87505
United States, New York
New York Oncology Hematology, PC at Albany Regional Cancer Care
Albany, New York, United States, 12208
Our Lady of Mercy Medical Center Comprehensive Cancer Center
Bronx, New York, United States, 10466
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263-0001
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326
Falck Cancer Center at Arnot Ogden Medical Center
Elmira, New York, United States, 14905
Catskill Regional Medical Center Cancer Care Center
Harris, New York, United States, 12742
New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program
Hudson, New York, United States, 12534
New York Oncology Hematology, PC
Latham, New York, United States, 12110
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown, New York, United States, 10940-4199
Beth Israel Medical Center - Petrie Division
New York, New York, United States, 10003-3803
St. Luke's - Roosevelt Hospital Center - St.Luke's Division
New York, New York, United States, 10025
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center
Plattsburgh, New York, United States, 12901
Dyson Center for Cancer Care at Vassar Brothers Medical Center
Poughkeepsie, New York, United States, 12601-3990
Riverview Cancer Care Medical Associates, PC
Rexford, New York, United States, 12148
Lipson Cancer and Blood Center at Rochester General Hospital
Rochester, New York, United States, 14621
New York Oncology Hematology, P.C. - Ellis Office
Schenectady, New York, United States, 12308
Nalitt Cancer Institute at Staten Island University Hospital
Staten Island, New York, United States, 10305
CCOP - Hematology-Oncology Associates of Central New York
Syracuse, New York, United States, 13057
Samaritan Hospital at Northeast Health
Troy, New York, United States, 12180
United States, North Carolina
Randolph Hospital
Asheboro, North Carolina, United States, 27203-5400
Mission Hospitals - Memorial Campus
Asheville, North Carolina, United States, 28801
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States, 27599-7295
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, United States, 28232-2861
Batte Cancer Center at Northeast Medical Center
Concord, North Carolina, United States, 28025
Cape Fear Valley Medical Center
Fayetteville, North Carolina, United States, 28304
CaroMont Cancer Center at Gaston Memorial Hospital
Gastonia, North Carolina, United States, 28053
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, United States, 27403-1198
Pardee Memorial Hospital
Hendersonville, North Carolina, United States, 28791
Lenoir Memorial Cancer Center
Kinston, North Carolina, United States, 28501
Rex Cancer Center at Rex Hospital
Raleigh, North Carolina, United States, 27607
Annie Penn Cancer Center
Reidsville, North Carolina, United States, 27320
Rutherford Hospital
Rutherfordton, North Carolina, United States, 28139
Iredell Memorial Hospital
Statesville, North Carolina, United States, 28677
Zimmer Cancer Center at New Hanover Regional Medical Center
Wilmington, North Carolina, United States, 28401
United States, North Dakota
Bismarck Cancer Center
Bismarck, North Dakota, United States, 58501
Mid Dakota Clinic, P. C.
Bismarck, North Dakota, United States, 58501
Cancer Care Center at Medcenter One Hospital
Bismarck, North Dakota, United States, 58501
St. Alexius Medical Center
Bismarck, North Dakota, United States, 58502
CCOP - MeritCare Hospital
Fargo, North Dakota, United States, 58122
MeritCare Medical Group
Fargo, North Dakota, United States, 58122
Dakota Cancer Institute at Innovis Health - Dakota Clinic
Fargo, North Dakota, United States, 58103
Altru Cancer Center at Altru Hospital
Grand Forks, North Dakota, United States, 58201
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
United States, Ohio
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, United States, 44307
Akron City Hospital
Akron, Ohio, United States, 44309-2090
Wood County Oncology Center
Bowling Green, Ohio, United States, 43402
Aultman Hospital Cancer Center at Aultman Health Foundation
Canton, Ohio, United States, 44710-1799
Mercy Cancer Center at Mercy Medical Center
Canton, Ohio, United States, 44708
Adena Regional Medical Center
Chillicothe, Ohio, United States, 45601
Cancer Treatment Center at Good Samaritan Hospital
Cincinnati, Ohio, United States, 45220
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, United States, 45267
Oncology Hematology Care, Incorporated - Blue Ash
Cincinnati, Ohio, United States, 45242
Huron Hospital Cancer Care Center
Cleveland, Ohio, United States, 44112
Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Euclid Hospital
Cleveland, Ohio, United States, 44119
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
Columbus, Ohio, United States, 43210-1240
Doctors Hospital at Ohio Health
Columbus, Ohio, United States, 43228
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, United States, 43214-3998
CCOP - Columbus
Columbus, Ohio, United States, 43215
Grant Riverside Cancer Services
Columbus, Ohio, United States, 43215
Mount Carmel Health - West Hospital
Columbus, Ohio, United States, 43222
CCOP - Dayton
Dayton, Ohio, United States, 45429
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, United States, 45409
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, United States, 45428
Good Samaritan Hospital
Dayton, Ohio, United States, 45406
Grandview Hospital
Dayton, Ohio, United States, 45405
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Fremont Memorial Hospital
Fremont, Ohio, United States, 43420
Charles F. Kettering Memorial Hospital
Kettering, Ohio, United States, 45429
Fairfield Medical Center
Lancaster, Ohio, United States, 43130
Lima Memorial Hospital
Lima, Ohio, United States, 45804
St. Rita's Medical Center
Lima, Ohio, United States, 45801
MedCentral - Mansfield Hospital
Mansfield, Ohio, United States, 44903
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
St. Luke's Hospital
Maumee, Ohio, United States, 43537
Northwest Ohio Oncology Center
Maumee, Ohio, United States, 43537
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights, Ohio, United States, 44124
Middletown Regional Hospital
Middletown, Ohio, United States, 45044
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, United States, 43055
St. Charles Mercy Hospital
Oregon, Ohio, United States, 43616
Toledo Clinic - Oregon
Oregon, Ohio, United States, 43616
Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
North Coast Cancer Care, Incorporated
Sandusky, Ohio, United States, 44870
Community Hospital of Springfield and Clark County
Springfield, Ohio, United States, 45505
Mercy Medical Center
Springfield, Ohio, United States, 45504
Flower Hospital Cancer Center
Sylvania, Ohio, United States, 43560
Mercy Hospital of Tiffin
Tiffin, Ohio, United States, 44883
Toledo Hospital
Toledo, Ohio, United States, 43606
CCOP - Toledo Community Hospital
Toledo, Ohio, United States, 43623
Medical University of Ohio Cancer Center
Toledo, Ohio, United States, 43614
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, United States, 43623
St. Vincent Mercy Medical Center
Toledo, Ohio, United States, 43608
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, United States, 45373-1300
St. Joseph Cancer Center at St. Joseph Health Center
Warren, Ohio, United States, 44484
South Pointe Hospital Cancer Care Center
Warrensville Heights, Ohio, United States, 44122
Fulton County Health Center
Wauseon, Ohio, United States, 43567
Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
Westerville, Ohio, United States, 43081
United States Air Force Medical Center - Wright-Patterson
Wright-Patterson Afb, Ohio, United States, 45433-5529
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, United States, 45385
Tod Children's Hospital - Forum Health
Youngstown, Ohio, United States, 44501
Genesis - Good Samaritan Hospital
Zanesville, Ohio, United States, 43701
United States, Oklahoma
Cleo Craig Cancer Research Clinic
Lawton, Oklahoma, United States, 73505
Cancer Care Associates - Mercy Campus
Oklahoma City, Oklahoma, United States, 73120
Oklahoma University Medical Center
Oklahoma City, Oklahoma, United States, 73104
LaFortune Cancer Center at St. John Medical Center
Tulsa, Oklahoma, United States, 74104
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, United States, 74136
United States, Oregon
Legacy Mount Hood Medical Center
Gresham, Oregon, United States, 97030
Providence Milwaukie Hospital
Milwaukie, Oregon, United States, 97222
Legacy Emanuel Hospital and Health Center & Children's Hospital
Portland, Oregon, United States, 97227
Kaiser Permanente Health Care - Portland
Portland, Oregon, United States, 97232
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center
Portland, Oregon, United States, 97210
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, United States, 97213-2967
CCOP - Columbia River Oncology Program
Portland, Oregon, United States, 97225
Legacy Meridian Park Hospital
Tualatin, Oregon, United States, 97062
United States, Pennsylvania
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, United States, 18105
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States, 19010
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-0001
Mercy Fitzgerald Hospital
Darby, Pennsylvania, United States, 19023
Cancer Program of Doylestown Hospital
Doylestown, Pennsylvania, United States, 18901
Dale and Frances Hughes Cancer Center at Pocono Medical Center
East Stroudsburg, Pennsylvania, United States, 18301
Ephrata Cancer Center at Ephrata Community Hospital
Ephrata, Pennsylvania, United States, 17522
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg, Pennsylvania, United States, 17105
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Richard G. Laube Cancer Center at ACMH
Kittanning, Pennsylvania, United States, 16201
St. Mary Regional Cancer Center
Langhorne, Pennsylvania, United States, 19047
Central Pennsylvania Hematology and Medical Oncology Associates, PC
Lemoyne, Pennsylvania, United States, 17043
Cancer Center at Riddle Memorial Hospital
Media, Pennsylvania, United States, 19063
Norristown Regional Cancer Center
Norristown, Pennsylvania, United States, 19401
Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301-1792
Frankford Hospital - Torresdale Campus
Philadelphia, Pennsylvania, United States, 19114
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States, 19107-5541
Hillman Cancer Center at University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, United States, 15232
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, United States, 15224-1791
St. Joseph Medical Center
Reading, Pennsylvania, United States, 19604
Reading Hospital and Medical Center
Reading, Pennsylvania, United States, 19612-6052
Guthrie Cancer Center at Guthrie Clinic Sayre
Sayre, Pennsylvania, United States, 18840
Hematology and Oncology Associates
Scranton, Pennsylvania, United States, 18510
Grand View Hospital
Sellersville, Pennsylvania, United States, 18960
Mount Nittany Medical Center
State College, Pennsylvania, United States, 16803
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, United States, 16801
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
Upland, Pennsylvania, United States, 19013
Jennersville Regional Hospital
West Grove, Pennsylvania, United States, 19390-9499
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States, 18711
CCOP - MainLine Health
Wynnewood, Pennsylvania, United States, 19096
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, United States, 19096
York Cancer Center at Wellspan Health
York, Pennsylvania, United States, 17405
United States, Rhode Island
Kent County Memorial Hospital
Warwick, Rhode Island, United States, 02886
United States, South Carolina
Cancer Care Institute of Carolina at Aiken Regional Medical Centers
Aiken, South Carolina, United States, 29801
AnMed Health Cancer Center
Anderson, South Carolina, United States, 29621
Roper St. Francis Cancer Center at Roper Hospital
Charleston, South Carolina, United States, 29401
CCOP - Greenville
Greenville, South Carolina, United States, 29615
Bon Secours St. Francis Health System
Greenville, South Carolina, United States, 29601
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, United States, 29303
CCOP - Upstate Carolina
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Oncology Services of Aberdeen
Aberdeen, South Dakota, United States, 57401
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, United States, 57117-5039
Medical X-Ray Center, PC
Sioux Falls, South Dakota, United States, 57105
United States, Tennessee
Jones Clinic - Germantown
Germantown, Tennessee, United States, 38138
Thompson Cancer Survival Center
Knoxville, Tennessee, United States, 37916
Baptist Regional Cancer Center at Baptist Hospital of East Tennessee
Knoxville, Tennessee, United States, 37901
University of Tennessee Cancer Institute - Medical Center
Memphis, Tennessee, United States, 38104
United States, Texas
Harrington Cancer Center
Amarillo, Texas, United States, 79106
Texas Oncology, PA at South Austin Cancer Center
Austin, Texas, United States, 78745
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
UMC Southwest Cancer and Research Center
Lubbock, Texas, United States, 79415-3364
CCOP - Scott and White Hospital
Temple, Texas, United States, 76508
United States, Utah
American Fork Hospital
American Fork, Utah, United States, 84003
Logan Regional Hospital
Logan, Utah, United States, 84321
Cottonwood Hospital Medical Center
Murray, Utah, United States, 84107
McKay-Dee Hospital Center
Ogden, Utah, United States, 84403
Utah Valley Regional Medical Center - Provo
Provo, Utah, United States, 84604
Dixie Regional Medical Center - East Campus
Saint George, Utah, United States, 84770
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, United States, 84106
LDS Hospital
Salt Lake City, Utah, United States, 84143
United States, Vermont
Mountainview Medical
Berlin, Vermont, United States, 05602
Fletcher Allen Health Care - University Health Center Campus
Burlington, Vermont, United States, 05401
United States, Virginia
Martha Jefferson Hospital Cancer Care Center
Charlottesville, Virginia, United States, 22901
Danville Regional Medical Center
Danville, Virginia, United States, 24541
Lynchburg Hematology-Oncology Clinic
Lynchburg, Virginia, United States, 24501
Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
Martinsville, Virginia, United States, 24115
Peninsula Cancer Institute
Newport News, Virginia, United States, 23601
Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia, United States, 23298-0037
Virginia Cancer Institute - West End
Richmond, Virginia, United States, 23230
Carilion Cancer Center of Western Virginia
Roanoke, Virginia, United States, 24014
United States, Washington
Overlake Cancer Center at Overtake Hospital Medical Center
Bellevue, Washington, United States, 98004
St. Joseph Cancer Center
Bellingham, Washington, United States, 98225
Olympic Hematology and Oncology
Bremerton, Washington, United States, 98310
Cascade Cancer Center at Evergreen Hospital Medical Center
Kirkland, Washington, United States, 98033
Skagit Valley Hospital Cancer Care Center
Mt. Vernon, Washington, United States, 98273
Olympic Medical Center
Port Angeles, Washington, United States, 98362
Valley Medical Center
Renton, Washington, United States, 98055
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98104
Group Health Central Hospital
Seattle, Washington, United States, 98104-1387
CCOP - Virginia Mason Research Center
Seattle, Washington, United States, 98101
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, United States, 98122-4307
Rockwood Clinic Cancer Treatment Center
Spokane, Washington, United States, 99204-2967
Cancer Care Northwest - North
Spokane, Washington, United States, 99218
Madigan Army Medical Center - Tacoma
Tacoma, Washington, United States, 98431
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, United States, 98668
St. Mary Regional Cancer Center at St. Mary Medical Center
Walla Walla, Washington, United States, 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, United States, 98902
Washington Hematology-Oncology Specialists
Yakima, Washington, United States, 98902
United States, West Virginia
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Charleston, West Virginia, United States, 25304
United Hospital Center
Clarksburg, West Virginia, United States, 26301
Marshall University Medical Center
Huntington, West Virginia, United States, 25701
St. Mary's Regional Cancer Center at St. Mary's Medical Center
Huntington, West Virginia, United States, 25702
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
Parkersburg, West Virginia, United States, 26102
United States, Wisconsin
Fox Valley Hematology and Oncology - East Grant Street
Appleton, Wisconsin, United States, 54911-3496
Vince Lombardi Cancer Center - Elkhorn
Elkhorn, Wisconsin, United States, 53121
Oncology Alliance, SC - Milwaukee - East
Glendale, Wisconsin, United States, 53212-1038
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, United States, 54307-3508
Green Bay Oncology, Limited at St. Vincent Hospital
Green Bay, Wisconsin, United States, 54301-3526
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, United States, 54303
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, United States, 54303
Mercy Regional Cancer Center
Janesville, Wisconsin, United States, 53547
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792-6164
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc, Wisconsin, United States, 54221-1450
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, United States, 54143
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, United States, 54449
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, United States, 53226
Medical Consultants, Limited
Milwaukee, Wisconsin, United States, 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53201-0342
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, United States, 53066
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls, Wisconsin, United States, 54154
All Saints Cancer Center at All Saints Healthcare
Racine, Wisconsin, United States, 53405
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan, Wisconsin, United States, 53081
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, United States, 53188
United States, Wyoming
Welch Cancer Center at Sheridan Memorial Hospital
Sheridan, Wyoming, United States, 82801
Puerto Rico
Andres Grillasca Hospital
Ponce, Puerto Rico, 00733
San Juan City Hospital
San Juan, Puerto Rico, 00928
Sponsors and Collaborators
Investigators
Principal Investigator: Norman Wolmark, MD NSABP Foundation, Inc.
  More Information

Additional Information:
Publications:
Allegra CJ, Yothers G, O'Connell MJ, et al.: Initial safety report of NSABP C-08, a randomized phase III study of modified 5-fluorouracil (5-FU)/leucovorin (LCV) and oxaliplatin (OX) (mFOLFOX6) with or without bevacizumab (bev) in the adjuvant treatment of patients with stage II/III colon cancer. [Abstract] J Clin Oncol 26 (Suppl 15): A-4006, 2008.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00096278     History of Changes
Other Study ID Numbers: NCI-2012-03017, NSABP C-08
Study First Received: November 9, 2004
Results First Received: October 31, 2012
Last Updated: January 2, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by National Cancer Institute (NCI):
adenocarcinoma of the colon
stage II colon cancer
stage III colon cancer

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Fluorouracil
Oxaliplatin
Bevacizumab
Leucovorin
Levoleucovorin
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antimetabolites, Antineoplastic
Antineoplastic Agents
Therapeutic Uses
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Vitamin B Complex
Vitamins
Micronutrients
Growth Substances

ClinicalTrials.gov processed this record on May 23, 2013