Interferon Alfa-2b With or Without Bevacizumab in Treating Patients With Advanced Renal Cell Carcinoma (Kidney Cancer)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
NCIC Clinical Trials Group
Eastern Cooperative Oncology Group
Information provided by (Responsible Party):
Cancer and Leukemia Group B
ClinicalTrials.gov Identifier:
NCT00072046
First received: November 4, 2003
Last updated: March 15, 2012
Last verified: April 2011
  Purpose

RATIONALE: Biological therapies, such as interferon alfa-2b, may interfere with the growth of tumor cells. Bevacizumab may stop the growth of tumor cells by stopping blood flow to the tumor. It is not yet known whether interferon alfa-2b is more effective with or without bevacizumab in treating advanced renal cell carcinoma (kidney cancer).

PURPOSE: This randomized phase III trial is studying interferon alfa-2b and bevacizumab to see how well they work compared to interferon alfa-2b alone in treating patients with advanced renal cell carcinoma.


Condition Intervention Phase
Kidney Cancer
Biological: bevacizumab
Biological: recombinant interferon alfa
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma

Resource links provided by NLM:


Further study details as provided by Cancer and Leukemia Group B:

Primary Outcome Measures:
  • Overall Survival [ Time Frame: 5 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Time to progression [ Time Frame: q 3 cycles ] [ Designated as safety issue: No ]
  • Toxicity [ Time Frame: q cycle ] [ Designated as safety issue: Yes ]

Enrollment: 732
Study Start Date: October 2003
Estimated Study Completion Date: July 2015
Primary Completion Date: January 2004 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Interferon
Treatment with interferon alfa 2b
Biological: recombinant interferon alfa
9 million units subQ injection 3 x/week for 4 weeks
Experimental: Interferon + bevacizumab
Addition of bevacizumab to interferon alfa 2b treatment
Biological: bevacizumab
10mg/kg IV infusion on Days 1 & 15 of each cycle
Biological: recombinant interferon alfa
9 million units subQ injection 3 x/week for 4 weeks

Detailed Description:

OBJECTIVES:

Primary

  • Compare the overall survival of patients with advanced renal cell carcinoma treated with interferon alfa-2b alone or interferon alfa-2b with bevacizumab.

Secondary

  • Compare the time to disease progression and objective response rates in patients treated with these regimens.
  • Determine the toxicity of interferon alfa-2b in combination with bevacizumab in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to prior nephrectomy (yes vs no) and number of risk factors for disease progression (0 vs 1-2 vs 3 or more). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive interferon alfa-2b subcutaneously (SC) three times a week.
  • Arm II: Patients receive interferon alfa-2b as in arm I and bevacizumab IV over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years and then annually for up to 10 years after study entry.

PROJECTED ACCRUAL: A total of 700 patients (350 per treatment arm) will be accrued for this study within 3 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed renal cell carcinoma (RCC)

    • Conventional clear cell carcinoma
    • Metastatic or unresectable disease
  • The following characteristics and cellular types are excluded:

    • True papillary
    • Sarcomatoid features without a clear cell component
    • Chromophobe
    • Oncocytoma
    • Collecting duct tumor
    • Transitional cell carcinoma
  • Measurable or nonmeasurable disease, including any of the following:

    • Unidimensionally measurable lesion ≥ 20 mm by conventional techniques (e.g., physical exam or chest x-ray) OR 10 mm by spiral CT scan or MRI
    • The following are considered nonmeasurable disease:

      • Small lesions
      • Bone lesions
      • Leptomeningeal disease
      • Ascites
      • Pleural/pericardial effusion
      • Lymphangitis cutis/pulmonis
      • Abdominal masses that are not confirmed and followed by imaging techniques
      • Cystic lesions
      • Irradiated lesions, unless progression is documented after radiotherapy
  • RCC paraffin tissue blocks or unstained slides must be available
  • No evidence of prior or concurrent CNS metastases by MRI or CT scan

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • Karnofsky 70-100%

Life expectancy

  • Not specified

Hematopoietic

  • Granulocyte count ≥ 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • No history of clinically significant bleeding

Hepatic

  • AST/ALT ≤ 2.5 times upper limit of normal (ULN)
  • Alkaline phosphatase ≤ 2.5 times ULN
  • Bilirubin ≤ 1.5 times ULN

Renal

  • Creatinine ≤ 1.5 times ULN
  • No proteinuria > 1+

    • Proteinuria ≥ 2+ allowed provided protein is < 2 g/24-hour urine collection

Cardiovascular

  • No deep venous thrombosis within the past year
  • No cerebrovascular accident within the past year
  • No peripheral vascular disease with claudication on < 1 block
  • No uncontrolled hypertension defined as blood pressure ≥160 mm Hg (systolic) and/or ≥ 90 mm Hg (diastolic) while on medication
  • No New York Heart Association class II-IV congestive heart failure
  • No angina pectoris requiring nitrate therapy
  • No myocardial infarction within the past 6 months
  • No other significant cardiovascular disease

Pulmonary

  • No pulmonary embolus within the past year
  • No ongoing hemoptysis

Other

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception during and for 3 months after study treatment
  • No preexisting thyroid abnormality in which normal thyroid function cannot be maintained by medication
  • No delayed wound healing, ulcers, or bone fractures
  • No uncontrolled psychiatric disorder
  • No other currently active* malignancy except nonmelanoma skin cancer NOTE: *Disease is not considered currently active if patient completed anticancer therapy and is considered to have < 30% risk of relapse

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • No prior systemic immunotherapy for RCC
  • No prior thalidomide, anti-vascular endothelial growth factor (VEGF) therapy, VEGF receptor inhibitors, or antiangiogenic treatment of any kind
  • No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)

Chemotherapy

  • No prior systemic chemotherapy for RCC
  • No concurrent chemotherapy

Endocrine therapy

  • No concurrent systemic corticosteroid therapy except the following:

    • Topical and inhaled steroids
    • Replacement therapy for adrenal insufficiency
  • No concurrent hormones except those administered for nondisease-related conditions (e.g., insulin for diabetes)

Radiotherapy

  • See Disease Characteristics
  • At least 4 weeks since prior radiotherapy and recovered
  • Prior palliative radiotherapy to metastatic lesions allowed provided at least 1 measurable or nonmeasurable lesion remains untreated
  • No concurrent palliative radiotherapy

Surgery

  • At least 4 weeks since prior major surgery and recovered

Other

  • No other prior systemic investigational therapy for RCC
  • No other prior adjuvant or neoadjuvant systemic therapy for RCC
  • No concurrent full-dose oral or parenteral anticoagulation* NOTE: *Low-dose (1 mg) warfarin for maintenance of catheter patency and/or daily prophylactic aspirin is allowed
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00072046

  Hide Study Locations
Locations
United States, Alabama
Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Huntsville Hospital
Huntsville, Alabama, United States, 35801
United States, Arizona
CCOP - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States, 85259
United States, Arkansas
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Ft. Smith, Arkansas, United States, 72903
United States, California
Arroyo Grande Community Hospital
Arroyo Grande, California, United States, 93420
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Kaiser Permanente - Fremont
Fremont, California, United States, 94538
Kaiser Permanente Medical Center - Hayward
Hayward, California, United States, 94545
Providence Holy Cross Cancer Center
Mission Hills, California, United States, 91346-9600
Kaiser Permanente Medical Center - Oakland
Oakland, California, United States, 94611
St. Joseph Hospital Regional Cancer Center - Orange
Orange, California, United States, 92868
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, United States, 94063
Kaiser Permanente Medical Center - Richmond
Richmond, California, United States, 94801
Kaiser Permanente Medical Center - Roseville
Roseville, California, United States, 95661
South Sacramento Kaiser-Permanente Medical Center
Sacramento, California, United States, 95823
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, United States, 95825
Naval Medical Center - San Diego
San Diego, California, United States, 92134
Veterans Affairs Medical Center - San Diego
San Diego, California, United States, 92161
Kaiser Permanente Medical Office -Vandever Medical Office
San Diego, California, United States, 92120
Rebecca and John Moores UCSD Cancer Center
San Diego, California, United States, 92103
UCSF Comprehensive Cancer Center
San Francisco, California, United States, 94115
Veterans Affairs Medical Center - San Francisco
San Francisco, California, United States, 94121
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, United States, 94115
San Francisco General Hospital Medical Center
San Francisco, California, United States, 94110
Kaiser Permanente Medical Center - Santa Teresa
San Jose, California, United States, 95119
Kaiser Foundation Hospital - San Rafael
San Rafael, California, United States, 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States, 95051
Kaiser Permanente Medical Center - Santa Rosa
Santa Rosa, California, United States, 95403
Kaiser Permanente Medical Center - South San Francisco
South San Francisco, California, United States, 94080
Kaiser Permanente Medical Facility - Stockton
Stockton, California, United States, 95210
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, United States, 94589
Kaiser Permanente Medical Center - Walnut Creek
Walnut Creek, California, United States, 94596
United States, Colorado
Aurora Presbyterian Hospital
Aurora, Colorado, United States, 80012
Boulder Community Hospital
Boulder, Colorado, United States, 80301
Cancer Center of Colorado Springs
Colorado Springs, Colorado, United States, 80907
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States, 80933
Memorial Hospital Cancer Center
Colorado Springs, Colorado, United States, 80909
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States, 80224-2522
Presbyterian - St. Luke's Medical Center
Denver, Colorado, United States, 80218
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Rose Medical Center
Denver, Colorado, United States, 80220
St. Joseph Hospital
Denver, Colorado, United States, 80218
Swedish Medical Center
Englewood, Colorado, United States, 80110
Front Range Cancer Specialists
Fort Collins, Colorado, United States, 80524
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, United States, 80502
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States, 81004
North Suburban Medical Center
Thorton, Colorado, United States, 80229
United States, Connecticut
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States, 06105
Middlesex Hospital Cancer Center
Middletown, Connecticut, United States, 06457
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States, 06520-8032
Norwalk Hospital
Norwalk, Connecticut, United States, 06856
United States, Delaware
Kent General Hospital at Bayhealth Medical Center
Dover, Delaware, United States, 19901
Beebe Medical Center
Lewes, Delaware, United States, 19958
CCOP - Christiana Care Health Services
Newark, Delaware, United States, 19718
St. Francis Hospital
Wilmington, Delaware, United States, 19805
United States, District of Columbia
Lombardi Cancer Center at Georgetown University Medical Center
Washington, District of Columbia, United States, 20007
Walter Reed Army Medical Center
Washington, District of Columbia, United States, 20307
United States, Florida
Lynn Regional Cancer Center of Boca Raton Community Hospital
Boca Raton, Florida, United States, 33486
Halifax Medical Center
Daytona Beach, Florida, United States, 32115
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Shands Cancer Center at the University of Florida - Jacksonville
Gainesville, Florida, United States, 32610
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, Florida, United States, 33021
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224-9980
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States, 33458
Lakeland Regional Cancer Center at Lakeland Regional Medical Center
Lakeland, Florida, United States, 33805
Watson Clinic
Lakeland, Florida, United States, 33805
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Florida Oncology Associates
Orange Park, Florida, United States, 32073
Florida Hospital - Orlando
Orlando, Florida, United States, 32803
Florida Cancer Specialists
Sarasota, Florida, United States, 34236
Palm Beach Cancer Institute - West Palm Beach
West Palm Beach, Florida, United States, 33401
United States, Georgia
Phoebe Cancer Center at Phoebe Putney Memorial Hospital
Albany, Georgia, United States, 31703
Emory University Hospital - Atlanta
Altanta, Georgia, United States, 30322
Hematology and Oncology of Northeast Georgia
Athens, Georgia, United States, 30607
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, United States, 30342
CCOP - Atlanta Regional
Atlanta, Georgia, United States, 30342
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Northside Hospital Cancer Center
Atlanta, Georgia, United States, 30342
Augusta Oncology Associates
Augusta, Georgia, United States, 30901
MBCCOP-Medical College of Georgia Cancer Center
Augusta, Georgia, United States, 30912
WellStar Cobb Hospital
Austell, Georgia, United States, 30106
John B. Amos Community Cancer Center
Columbus, Georgia, United States, 31902
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, United States, 30033
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur, Georgia, United States, 30033
Northeast Georgia Medical Center
Gainesville, Georgia, United States, 30501
Gwinnett Medical Center
Lawrenceville, Georgia, United States, 30045
Medical Center of Central Georgia
Macon, Georgia, United States, 31208
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, United States, 30060
Southern Regional Medical Center
Riverdale, Georgia, United States, 30274
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States, 31403
Cancer Care and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, United States, 31405
United States, Hawaii
Kapiolani Medical Center at Pali Momi
Aiea, Hawaii, United States, 96701
Cancer Research Center of Hawaii
Honolula, Hawaii, United States, 96813
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
St. Francis Medical Center
Honolulu, Hawaii, United States, 96817
OnCare Hawaii, Incorporated - Lusitana
Honolulu, Hawaii, United States, 96813
Queen's Cancer Institute at Queen's Medical Center
Honolulu, Hawaii, United States, 96813
OnCare Hawaii, Incorporated - Kuakini
Honolulu, Hawaii, United States, 96817
Straub Clinic and Hospital, Incorporated
Honolulu, Hawaii, United States, 96813
United States, Idaho
Mountain States Tumor Institute - Boise
Boise, Idaho, United States, 83712
United States, Illinois
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, United States, 62002
Rush-Copley Cancer Care Center
Aurora, Illinois, United States, 60507
St. Joseph Medical Center
Bloomington, Illinois, United States, 61701
Graham Hospital
Canton, Illinois, United States, 61520
Memorial Hospital
Carthage, Illinois, United States, 62321
University of Illinois Medical Center
Chicago, Illinois, United States, 60612
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637-1470
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States, 62526
Alexian Brothers Cancer Care Center
Elk Grove Village, Illinois, United States, 60007
Eureka Hospital
Eureka, Illinois, United States, 61530
Evanston Northwestern Health Care - Evanston Hospital
Evanston, Illinois, United States, 60201
Galesburg Clinic
Galesburg, Illinois, United States, 61401
Galesburg Cottage Hospital
Galesburg, Illinois, United States, 61401
Medical and Surgical Specialists, LLC
Galesburg, Illinois, United States, 61401
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, United States, 61401
Mason District Hospital
Havana, Illinois, United States, 62644
Hopedale Medical Complex
Hopedale, Illinois, United States, 61747
Joliet Oncology Hematology Associates, Limited - West
Joliet, Illinois, United States, 60435
Provena St. Mary's Wasser Regional Cancer Center - Kankakee
Kankakee, Illinois, United States, 60901
Kewanee Hospital
Kewanee, Illinois, United States, 61443
La Grange Memorial Hospital
La Grange, Illinois, United States, 60525
McDonough District Hospital
Macomb, Illinois, United States, 61455
Trinity Medical Center - East
Moline, Illinois, United States, 61265
Hematology Oncology Consultants Ltd.
Naperville, Illinois, United States, 60540
BroMenn Regional Medical Center
Normal, Illinois, United States, 61761
Community Cancer Center
Normal, Illinois, United States, 61761
Oncology Hematology Associates of Central Illinois - Ottawa
Ottawa, Illinois, United States, 61350
Community Hospital of Ottawa
Ottawa, Illinois, United States, 61350
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States, 61554
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, United States, 61615
Proctor Hospital
Peoria, Illinois, United States, 61614
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61603
OSF St. Francis Medical Center
Peoria, Illinois, United States, 61637
CCOP - Illinois Oncology Research Association
Peoria, Illinois, United States, 61615
Illinois Valley Community Hospital
Peru, Illinois, United States, 61354
Perry Memorial Hospital
Princeton, Illinois, United States, 61356
Swedish American Hospital
Rockford, Illinois, United States, 61104
St. Margaret's Hospital
Spring Valley, Illinois, United States, 61362
Valley Cancer Center
Spring Valley, Illinois, United States, 61362
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, United States, 62781-0001
CCOP - Carle Cancer Center
Urbana, Illinois, United States, 61801
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, United States, 61801
United States, Indiana
St. Francis Hospital and Health Centers
Beech Grove, Indiana, United States, 46107
Elkhart General Hospital
Elkhart, Indiana, United States, 46515
Fort Wayne Medical Oncology and Hematology, Incorporated
Fort Wayne, Indiana, United States, 46815
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, United States, 46350
Oncology Institute of Greater Lafayette
Lafayette, Indiana, United States, 47904
Saint Anthony Memorial Health Centers
Michigan City, Indiana, United States, 46360
Saint Joseph Regional Medical Center - Plymouth Campus
Plymouth, Indiana, United States, 46544
Memorial Hospital of South Bend
South Bend, Indiana, United States, 46601
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, United States, 46601
United States, Iowa
McFarland Clinic, P.C.
Ames, Iowa, United States, 50010
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, United States, 52722
Saint Anthony Regional Hospital
Carroll, Iowa, United States, 51401
St. Luke's Hospital
Cedar Rapids, Iowa, United States, 52402
Iowa Blood and Cancer Care
Cedar Rapids, Iowa, United States, 52402
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, United States, 52403
Mercy Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Alegent Health Mercy Hospital
Council Bluffs, Iowa, United States, 51503
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States, 52803
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, United States, 50309
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Mercy Capitol Hospital
Des Moines, Iowa, United States, 50307
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, United States, 50309
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, United States, 50314
Wendt Regional Cancer Center at Finley Hospital
Dubuque, Iowa, United States, 52001
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, United States, 52242
Alegent Health Community Memorial Hospital
Missouri Valley, Iowa, United States, 51555
Burgess Health Center
Onawa, Iowa, United States, 51040
Cancer Center at Ottumwa Regional Health Center
Ottumwa, Iowa, United States, 52501
St. Luke's Regional Medical Center
Sioux City, Iowa, United States, 51104
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States, 51104
Siouxland Hematology-Oncology Associates
Sioux City, Iowa, United States, 51101
United States, Kansas
Cancer Center of Kansas - Chanute
Chanute, Kansas, United States, 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States, 67801
Cancer Center of Kansas, P.A. - El Dorado
El Dorado, Kansas, United States, 67042
Cancer Center of Kansas - Kingman
Kingman, Kansas, United States, 67068
Southwest Medical Center
Liberal, Kansas, United States, 67901
Cancer Center of Kansas - Newton
Newton, Kansas, United States, 67114
Cancer Center of Kansas, P.A. - Parsons
Parsons, Kansas, United States, 67357
Mount Carmel Regional Cancer Center
Pittsburg, Kansas, United States, 66762
Pratt Cancer Center of Kansas
Pratt, Kansas, United States, 67124
Cancer Center of Kansas - Salina
Salina, Kansas, United States, 67042
St. Francis Comprehensive Cancer Center
Topeka, Kansas, United States, 66606
Cancer Center at Stormont-Vail Regional Health Center
Topeka, Kansas, United States, 66604
Cancer Center of Kansas - Wellington
Wellington, Kansas, United States, 67152
Cancer Center of Kansas, P.A.
Wichita, Kansas, United States, 67208
CCOP - Wichita
Wichita, Kansas, United States, 67214
Associates in Womens Health
Wichita, Kansas, United States, 67203
Cancer Center of Kansas, P.A. - Wichita
Wichita, Kansas, United States, 67214
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States, 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas, United States, 67156
United States, Louisiana
Baton Rouge General Regional Cancer Center
Baton Rouge, Louisiana, United States, 70806
Ochsner Clinic of Baton Rouge
Baton Rouge, Louisiana, United States, 708169990
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, United States, 70809
Terrebonne General Medical Center
Houma, Louisiana, United States, 70360
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, United States, 70112
CCOP - Ochsner
New Orleans, Louisiana, United States, 70121
Cancer Center at Medical Center of Louisiana - New Orleans
New Orleans, Louisiana, United States, 70112
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
United States, Maine
CancerCare of Maine at Eastern Maine Medial Center
Bangor, Maine, United States, 04401
United States, Maryland
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, United States, 21201-1595
St. Agnes Cancer Center
Baltimore, Maryland, United States, 21229
Union Hospital Cancer Center at Union Hospital
Elkton MD, Maryland, United States, 21921
United States, Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Cancer Center at Tufts - New England Medical Center
Boston, Massachusetts, United States, 02111
Lahey Clinic Medical Center - Burlington
Burlington, Massachusetts, United States, 01805
Commonwealth Hematology-Oncology P.C. - Quincy
Quincy, Massachusetts, United States, 02169
UMASS Memorial Cancer Center - University Campus
Worcester, Massachusetts, United States, 01655
United States, Michigan
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, United States, 49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106-0995
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, United States, 48100
Battle Creek Health System
Battle Creek, Michigan, United States, 49017
Mecosta County General Hospital
Big Rapids, Michigan, United States, 49307
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48532
Spectrum Health Hospital - Blodgett Campus
Grand Rapids, Michigan, United States, 49506
Metropolitan Hospital
Grand Rapids, Michigan, United States, 49506
Lacks Cancer Center at Saint Mary's Mercy Medical Center
Grand Rapids, Michigan, United States, 49503
CCOP - Grand Rapids
Grand Rapids, Michigan, United States, 49503
Spectrum Health Cancer Care - Butterworth Campus
Grand Rapids, Michigan, United States, 49503
Holland Community Hospital
Holland, Michigan, United States, 49423
Foote Hospital
Jackson, Michigan, United States, 49201
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Haematology-Oncology Associates of Ohio and Michigan, P.C.
Lambertville, Michigan, United States, 48144
Mercy Memorial Hospital System
Monroe, Michigan, United States, 48162
Community Cancer Center of Monroe
Monroe, Michigan, United States, 48162
Hackley Hospital
Muskegon, Michigan, United States, 49443
Northern Michigan Hospital
Petoskey, Michigan, United States, 49770
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, United States, 48073
Seton Cancer Institute - Saginaw
Saginaw, Michigan, United States, 48601
Oncology Care Associates, P.L.L.C.
Saint Joseph, Michigan, United States, 49085
Munson Medical Center
Traverse City, Michigan, United States, 49684
St. John Macomb Hospital
Warren, Michigan, United States, 48903
United States, Minnesota
MeritCare Clinic - Bemidji
Bemidji, Minnesota, United States, 56601
Brainerd Medical Center
Brainerd, Minnesota, United States, 56401
Fairview Ridges Hospital
Burnsville, Minnesota, United States, 55337
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Cancer Care Center at St. Luke's Hospital
Duluth, Minnesota, United States, 55802
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Mercy and Unity Cancer Center at Mercy and Unity Hospitals
Fridley, Minnesota, United States, 55432
Hutchinson Area Health Care
Hutchinson, Minnesota, United States, 55350
Meeker County Memorial Hospital
Litchfield, Minnesota, United States, 55355
St. John's Hospital
Maplewood, Minnesota, United States, 55109
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
Fairview University Medical Center - University Campus
Minneapolis, Minnesota, United States, 55455
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55417
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Chippewa County - Montevideo Hospital
Montevideo, Minnesota, United States, 56265
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, United States, 55422
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
Cancer Care Center at Regions Hospital
Saint Paul, Minnesota, United States, 55101
Saint Francis Cancer Center
Shakopee, Minnesota, United States, 55379
St. Joseph's Hospital
St Paul, Minnesota, United States, 55102
Adult and Pediatric Urology, P.L.L.P.
St. Cloud, Minnesota, United States, 56303
CentraCare Clinic - River Campus
St. Cloud, Minnesota, United States, 56303
Park Nicollet Clinic
St. Louis Park, Minnesota, United States, 55416
United Hospital
St. Paul, Minnesota, United States, 55102
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Woodwinds Hospital
Woodbury, Minnesota, United States, 55125
United States, Mississippi
Hattiesburg Clinic, P.A.
Hattiesburg, Mississippi, United States, 39401
Hematology & Oncology Clinic
Hattiesburg, Mississippi, United States, 34902
United States, Missouri
St. Francis Medical Center
Cape Girardeau, Missouri, United States, 63701
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Cape Girardeau, Missouri, United States, 63701
Saint Luke's Hospital
Chesterfield, Missouri, United States, 63017-3417
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, United States, 65203
Missouri Cancer Associates
Columbia, Missouri, United States, 65201
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, United States, 64804
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
David C. Pratt Cancer Center at St. John's Mercy
Saint Louis, Missouri, United States, 63141
CCOP - St. Louis-Cape Girardeau
Saint Louis, Missouri, United States, 63141
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, United States, 65807
St. John's Regional Health Center
Springfield, Missouri, United States, 65804
Missouri Baptist Cancer Center
St. Louis, Missouri, United States, 63131
St. Anthony's Cancer Center
St. Louis, Missouri, United States, 63128
United States, Montana
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
Great Falls Clinic
Great Falls, Montana, United States, 59405
Sletten Regional Cancer Institute
Great Falls, Montana, United States, 59405
United States, Nebraska
Fremont Area Medical Center
Fremont, Nebraska, United States, 68025
Cancer Center at the Good Samaritan Health Systems
Kearney, Nebraska, United States, 68847
Bryan LGH Medical Center West
Lincoln, Nebraska, United States, 68502
Cancer Resource Center - Lincoln
Lincoln, Nebraska, United States, 68510
St. Elizabeth Regional Medical Center
Lincoln, Nebraska, United States, 68510
Great Plains Regional Medical Center
North Platte, Nebraska, United States, 69103
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, United States, 68106
Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
Omaha, Nebraska, United States, 68114
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Cancer Center at Creighton University Medical Center
Omaha, Nebraska, United States, 68131
Midlands Cancer Center at Midlands Community Hospital
Papillion, Nebraska, United States, 68046
United States, Nevada
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States, 89102
Washoe Cancer Services at Washoe Medical Center - Reno
Reno, Nevada, United States, 89502
United States, New Hampshire
Kingsbury Center for Cancer Care at Cheshire Medical Center
Keene, New Hampshire, United States, 03431
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Elliot Regional Cancer Center
Manchester, New Hampshire, United States, 03103
Frisbie Memorial Hospital
Rochester, New Hampshire, United States, 03867
United States, New Jersey
Cancer Institute of New Jersey at the Cooper University Hospital
Camden, New Jersey, United States, 08103
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, United States, 07018-1095
Hunterdon Regional Cancer Center at Hunterdon Medical Center
Flemington, New Jersey, United States, 08822
CCOP - Northern New Jersey
Hackensack, New Jersey, United States, 07601
Cancer Institute of New Jersey at Hamilton
Hamilton, New Jersey, United States, 08690
St. Barnabas Medical Center
Livingston, New Jersey, United States, 07039
Cancer Center at the Mountainside Hospital
Montclair, New Jersey, United States, 07042
Carol G. Simon Cancer Center at Morristown Memorial Hospital
Morristown, New Jersey, United States, 07962
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States, 08903
Warren Hospital
Phillipsburg, New Jersey, United States, 08865
Overlook Hospital
Summit, New Jersey, United States, 07902
United States, New Mexico
Hematology-Oncology Associates, PC
Albuquerque, New Mexico, United States, 87106
Lovelace Medical Center at Lovelace Sandia Health System
Albuquerque, New Mexico, United States, 87108
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, United States, 87106
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, United States, 87108
New Mexico Cancer Care Associates
Santa Fe, New Mexico, United States, 87505
United States, New York
Comprehensive Cancer Center at Our Lady of Mercy Medical Center
Bronx, New York, United States, 10466
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326
Charles R. Wood Cancer Center at Glens Falls Hospital
Glens Falls, New York, United States, 12801
Beth Israel Medical Center - Petrie Division
New York, New York, United States, 10003
St. Luke's-Roosevelt Hospital Center - St.Luke's Division
New York, New York, United States, 10025
Union State Bank Cancer Center at Nyack Hospital
Nyack, New York, United States, 10960
Lipson Cancer and Blood Center at Rochester General Hospital
Rochester, New York, United States, 14621
Long Island Cancer Center at Stony Brook University Hospital
Stony Brook, New York, United States, 11794
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, United States, 13057
St. Joseph's Hospital Health Center - Syracuse
Syracuse, New York, United States, 13203
SUNY Upstate Medical University Hospital
Syracuse, New York, United States, 13210
Faxton Regional Cancer Center
Utica, New York, United States, 13502
United States, North Carolina
Randolph Hospital
Asheboro, North Carolina, United States, 27203
Mission Hospitals - Memorial Campus
Asheville, North Carolina, United States, 28801
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, United States, 28233
Batte Cancer Center at Northeast Medical Center
Concord, North Carolina, United States, 28025
Duke Comprehensive Cancer Center
Durham, North Carolina, United States, 27710
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
Eden, North Carolina, United States, 27288
Comprehensive Cancer Center at Gaston Memorial
Gastonia, North Carolina, United States, 28053
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, United States, 27534
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, United States, 27401
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
Greenville, North Carolina, United States, 27858
Pardee Memorial Hospital
Hendersonville, North Carolina, United States, 28791
Lenoir Memorial Cancer Center
Kinston, North Carolina, United States, 28501
Annie Penn Cancer Center
Reidsville, North Carolina, United States, 27320
Rutherford Hospital
Rutherfordton, North Carolina, United States, 28139
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, United States, 27157
Forsyth Regional Cancer Center at Forsyth Medical Center
Winston-Salem, North Carolina, United States, 27103
United States, North Dakota
Bismarck Cancer Center
Bismarck, North Dakota, United States, 58501
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, United States, 58501
Medcenter One Health System
Bismarck, North Dakota, United States, 58501
CCOP - MeritCare Hospital
Fargo, North Dakota, United States, 58122
MeritCare Medical Group
Fargo, North Dakota, United States, 58122
Dakota Cancer Institute at Innovis Health - Dakota Clinic
Fargo, North Dakota, United States, 58103
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
United States, Ohio
Akron City Hospital at Summa Health System
Akron, Ohio, United States, 44304
St. Elizabeth Boardman Cancer Center
Boardman, Ohio, United States, 44512
Wood County Oncology Center
Bowling Green, Ohio, United States, 43402
University Hospitals Ireland Cancer Center at Mercy Medical Center
Canton, Ohio, United States, 44708
Aultman Hospital Cancer Center at Aultman Health Foundation
Canton, Ohio, United States, 44710
Adena Regional Medical Center
Chillicothe, Ohio, United States, 54601
MetroHealth's Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
CCOP - Columbus
Columbus, Ohio, United States, 43215
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
Columbus, Ohio, United States, 43210
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, United States, 43214
Doctors Hospital at Ohio Health
Columbus, Ohio, United States, 43228
Mount Carmel West Hospital
Columbus, Ohio, United States, 43222
Grant Riverside Cancer Services
Columbus, Ohio, United States, 43215
Samaritan North Cancer Care Center
Dayton, Ohio, United States, 45415
Grandview Hospital
Dayton, Ohio, United States, 45405
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, United States, 45428
Good Samaritan Hospital
Dayton, Ohio, United States, 45406
CCOP - Dayton
Dayton, Ohio, United States, 45429
Miami Valley Hospital
Dayton, Ohio, United States, 45409
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Blanchard Valley Medical Associates
Findlay, Ohio, United States, 45840
Fremont Memorial Hospital
Fremont, Ohio, United States, 43420
Kenton Oncology, Inc.
Kenton, Ohio, United States, 43326
Charles F. Kettering Memorial Hospital
Kettering, Ohio, United States, 45429
Fairfield Medical Center
Lancaster, Ohio, United States, 43130
St. Rita's Medical Center
Lima, Ohio, United States, 45801
Lima Memorial Hospital
Lima, Ohio, United States, 45804
MedCentral - Mansfield Hospital
Mansfield, Ohio, United States, 44903
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
Northwest Ohio Oncology Center
Maumee, Ohio, United States, 43537
St. Luke's Hospital
Maumee, Ohio, United States, 43537
Middletown Regional Hospital
Middletown, Ohio, United States, 45044
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, United States, 43055
St. Charles Mercy Hospital
Oregon, Ohio, United States, 43616
Toledo Clinic
Oregon, Ohio, United States, 43616
Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
North Coast Cancer Care, Incorporated
Sandusky, Ohio, United States, 44870
Mercy Medical Center Oncology Unit
Springfield, Ohio, United States, 45504
Community Hospital of Springfield and Clark County
Springfield, Ohio, United States, 45505
Promedica Cancer Center at Flower Hospital
Sylvania, Ohio, United States, 43560
Mercy Hospital of Tiffin
Tiffin, Ohio, United States, 44883
CCOP - Toledo Community Hospital
Toledo, Ohio, United States, 43623
St. Vincent Mercy Medical Center
Toledo, Ohio, United States, 43608
Toledo Surgical Specialists
Toledo, Ohio, United States, 43623
Toledo Clinic, Incorporated
Toledo, Ohio, United States, 43623
Medical College of Ohio Cancer Institute
Toledo, Ohio, United States, 43614
Toledo Hospital
Toledo, Ohio, United States, 43606
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, United States, 45373
St. Joseph Health Care Center
Warren, Ohio, United States, 44484
Fulton County Health Center
Wauseon, Ohio, United States, 43567
United States Air Force Medical Center Wright-Patterson
Wright-Patterson Afb, Ohio, United States, 45433-5529
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, United States, 45385
St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
Youngstown, Ohio, United States, 44510
United States, Oklahoma
Comanche County Memorial Hospital
Lawton, Oklahoma, United States, 73505
Mercy Health Center
Oklahoma City, Oklahoma, United States, 73120
Oklahoma University Medical Center
Oklahoma City, Oklahoma, United States, 73104
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, United States, 74136
United States, Oregon
CCOP - Columbia River Oncology Program
Portland, Oregon, United States, 97225
Kaiser Permanente Health Care - Portland
Portland, Oregon, United States, 97232
United States, Pennsylvania
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18105
St. Luke's Hospital Cancer Center
Bethlehem, Pennsylvania, United States, 18015
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-2001
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center
Dubois, Pennsylvania, United States, 15801
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg, Pennsylvania, United States, 17105
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Lancaster General Hospital
Lancaster, Pennsylvania, United States, 17604
Central Pennsylvania Hematology and Medical Oncology Associates, PC
Lemoyne, Pennsylvania, United States, 17043
Lewistown Hospital
Lewistown, Pennsylvania, United States, 17044
Joan Karnell Cancer Center at Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19107
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, United States, 15224-1791
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, United States, 19464
Guthrie Medical Center - Sayre
Sayre, Pennsylvania, United States, 18840
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, United States, 18501
Hematology and Oncology Associates
Scranton, Pennsylvania, United States, 18510
Geisinger Medical Group
State College, Pennsylvania, United States, 16801
Mount Nittany Medical Center
State College, Pennsylvania, United States, 16803
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States, 18711
United States, Rhode Island
Miriam Hospital at Lifespan
Providence, Rhode Island, United States, 02906
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
United States, South Carolina
Rose Ramer Cancer Clinic at Anderson Area Medical Center
Anderson, South Carolina, United States, 29621
South Carolina Oncology Associates
Columbia, South Carolina, United States, 29210
Greenville Hospital System Cancer Center
Greenville, South Carolina, United States, 29605
CCOP - Greenville
Greenville, South Carolina, United States, 29615
Bon Secours St. Francis Health System
Greenville, South Carolina, United States, 29601
CCOP - Upstate Carolina
Spartanburg, South Carolina, United States, 29304
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, United States, 57104
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, United States, 57105
Medical X-Ray Center
Sioux Falls, South Dakota, United States, 57105
United States, Tennessee
Jones Clinic
Germantown, Tennessee, United States, 38138
Baptist Hospital Of East Tennessee
Knoxville, Tennessee, United States, 37920
Thompson Cancer Survival Center
Knoxville, Tennessee, United States, 37916
United States, Texas
Arlington Cancer Center - Arlington
Arlington, Texas, United States, 76012
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, United States, 75390
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
CCOP - Scott and White Hospital
Temple, Texas, United States, 76508
United States, Vermont
Mountainview Medical
Berlin, Vermont, United States, 05602
Fletcher Allen Health Care - University Health Center Campus
Burlington, Vermont, United States, 05401
United States, Virginia
Cancer Center at the University of Virginia
Charlottesville, Virginia, United States, 22908
Danville Regional Medical Center
Danville, Virginia, United States, 24541
Virginia Oncology Associates - Hampton
Hampton, Virginia, United States, 23666
Rappahannock General Hospital
Kilmarnock, Virginia, United States, 22482
Lynchburg Hematology-Oncology Clinic
Lynchburg, Virginia, United States, 24501
Massey Cancer Center at Virginia Commonwealth University
Richmond, Virginia, United States, 23298
United States, Washington
Providence Cancer Center at Holy Family Hospital
Spokane, Washington, United States, 99207
Providence Cancer Center at Sacred Heart Medical Center
Spokane, Washington, United States, 99204
North Star Lodge Cancer Center
Yakima, Washington, United States, 98902
Washington Hematology - Oncology Specialists
Yakima, Washington, United States, 98902
United States, West Virginia
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Charleston, West Virginia, United States, 25304
Marshall University Medical Center
Huntington, West Virginia, United States, 25701
St. Mary's Medical Center
Huntington, West Virginia, United States, 25702
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, United States, 26506
United States, Wisconsin
Fox Valley Hematology and Oncology
Appleton, Wisconsin, United States, 54911-3496
Vince Lombardi Cancer Center - Elkhorn
Elkhorn, Wisconsin, United States, 53121
Oncology Alliance, S.C. - Milwaukee - East
Glendale, Wisconsin, United States, 53212
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311-6519
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792
UW Health Oncology
Madison, Wisconsin, United States, 53715
Holy Family Memorial Medical Center
Manitowoc, Wisconsin, United States, 54221
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, United States, 54449
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, United States, 53226
Froedtert Hospital and Medical College of Wisconcin
Milwaukee, Wisconsin, United States, 53226-3596
Medical Consultants
Milwaukee, Wisconsin, United States, 53215
Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, United States, 53066-3896
All Saints Cancer Center at All Saints Healthcare
Racine, Wisconsin, United States, 53405
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan, Wisconsin, United States, 53081
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, United States, 53188
University of Wisconsin Cancer Center at Aspirus Wausau Hospital
Wausau, Wisconsin, United States, 54401
Canada, British Columbia
University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z4
Canada, Manitoba
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Canada, Nova Scotia
Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 1V8
Canada, Saskatchewan
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, Canada, S4T 7T1
Sponsors and Collaborators
Cancer and Leukemia Group B
NCIC Clinical Trials Group
Eastern Cooperative Oncology Group
Investigators
Study Chair: Brian I. Rini, MD University of California, San Francisco
  More Information

Additional Information:
Publications:
Rini BI, Halabi S, Rosenberg J, et al.: Bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in patients with metastatic renal cell carcinoma: results of overall survival for CALGB 90206. [Abstract] J Clin Oncol 27 (Suppl 15): A-LBA5019, 2009.
Rini BI, Halabi S, Rosenberg JE, et al.: CALGB 90206: a phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma. [Abstract] American Society of Clinical Oncology 2008 Genitourinary Cancers Symposium, Feb 14-16, 2008, San Francisco, CA. A-350, 2008.

Responsible Party: Cancer and Leukemia Group B
ClinicalTrials.gov Identifier: NCT00072046     History of Changes
Other Study ID Numbers: CDR0000335292, U10CA031946, CALGB-90206, CAN-NCIC-REC1, ECOG-CALGB-90206
Study First Received: November 4, 2003
Last Updated: March 15, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by Cancer and Leukemia Group B:
stage IV renal cell cancer
clear cell renal cell carcinoma
recurrent renal cell cancer

Additional relevant MeSH terms:
Carcinoma
Carcinoma, Renal Cell
Kidney Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Adenocarcinoma
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Interferon-alpha
Interferon Alfa-2a
Interferon Alfa-2b
Interferons
Reaferon
Bevacizumab
Antiviral Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Immunologic Factors
Physiological Effects of Drugs
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents
Adjuvants, Immunologic

ClinicalTrials.gov processed this record on July 28, 2014