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| Sponsor: | GPC Biotech |
|---|---|
| Information provided by: | GPC Biotech |
| ClinicalTrials.gov Identifier: | NCT00069745 |
Purpose
PURPOSE:
The SPARC trial is designed to compare the combination of the investigational oral cytotoxic drug, satraplatin, and prednisone, versus prednisone alone as second line chemotherapy in patients with hormone-refractory prostate cancer (HRPC).
TARGET PATIENT POPULATION:
The SPARC trial is intended for patients who have hormone-refractory prostate cancer (HRPC) and whose disease has progressed after treatment with one chemotherapy regimen. Please refer to the Eligibility Criteria page for the key inclusion and exclusion criteria.
WHAT IS SATRAPLATIN:
Satraplatin is a member of the platinum-based class of chemotherapy drugs. Platinum-based drugs have been clinically proven to be one of the most effective classes of anticancer therapies. Unlike the currently marketed platinum-based drugs, satraplatin can be given orally. Satraplatin is also the only platinum-based drug that has demonstrated efficacy against prostate cancer in a randomized trial.
RATIONALE:
There are currently no approved chemotherapy drugs for the second line treatment of hormone-refractory prostate cancer (HRPC). In a preliminary randomized trial conducted in Europe, the combination of satraplatin and prednisone had superior activity compared to prednisone alone, for the treatment of HRPC patients who had not previously been treated with chemotherapy
| Condition | Intervention | Phase |
|---|---|---|
|
Prostate Cancer Hormone Refractory Prostate Cancer One Prior Cytotoxic Chemotherapy Regimen |
Drug: Satraplatin Drug: Prednisone |
Phase III |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
| Official Title: | A Multi-National Phase III Study of Satraplatin Plus Prednisone or Placebo Plus Prednisone in Patients With Hormone Refractory Prostate Cancer Previously Treated With One Cytotoxic Chemotherapy Regimen |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations
Hide Study Locations| United States, Alabama | |
| Birmingham Hematology and Oncology | |
| Birmingham, Alabama, United States, 35235 | |
| Birmingham Hematology and Oncology | |
| Birmingham, Alabama, United States, 35205 | |
| United States, Arizona | |
| Hematology Oncology Associates | |
| Phoenix, Arizona, United States, 85012 | |
| Arizona Cancer Center | |
| Tuscon, Arizona, United States, 85724 | |
| Hematology Oncology Physicians/SMO | |
| Tucson, Arizona, United States, 85712 | |
| Northern AZ Hematology & Oncology Assoc. | |
| Sedona, Arizona, United States, 86336 | |
| United States, California | |
| Pacific Shores Medical Group | |
| Long Beach, California, United States, 90813 | |
| Sharp Healthcare - Clinical Oncology Research | |
| San Diego, California, United States, 92123 | |
| California Cancer Center | |
| Fresno, California, United States, 93720 | |
| University of California Davis Cancer Center, Division of Hematology-Oncology | |
| Sacramento, California, United States, 95817 | |
| Division of Hematology - Oncology | |
| Los Angeles, California, United States, 90095-7187 | |
| United States, Colorado | |
| Rocky Mountain Cancer Center - Midtown | |
| Denver, Colorado, United States, 80218 | |
| United States, Connecticut | |
| DeQuattro Community Cancer Center | |
| Manchester, Connecticut, United States, 06040 | |
| Hartford Hospital | |
| Hartford, Connecticut, United States, 06102 | |
| United States, Florida | |
| Cancer Centers of Florida-Altamonte | |
| Altamonte Springs, Florida, United States, 34761 | |
| Florida Cancer Institute | |
| New Port Richey, Florida, United States, 34655 | |
| Ocala Oncology Center | |
| Ocala, Florida, United States, 34474 | |
| Oncology and Hematology Associates of West Broward P.A. | |
| Tamarac, Florida, United States, 33321 | |
| Hematology/Oncology Associates of Treasure Coast | |
| Port St. Lucie, Florida, United States, 34952 | |
| South Florida Oncology & Hematology | |
| Plantation, Florida, United States, 33324 | |
| The Center for Hematology Oncology | |
| Boca Raton, Florida, United States, 33486 | |
| Hematology/Oncology Group of South Florida | |
| Miami, Florida, United States, 33176 | |
| Innovative Medical Research of South Florida | |
| Miami Shores, Florida, United States, 33179 | |
| United States, Illinois | |
| Northwest Medical Specialists | |
| Niles, Illinois, United States, 60714 | |
| North Shore Research Association | |
| Skokie, Illinois, United States, 60076 | |
| Decatur Memorial Hospital | |
| Decatur, Illinois, United States, 62526 | |
| United States, Indiana | |
| Central Indiana Cancer Centers | |
| Fishers, Indiana, United States, 46227 | |
| Indiana Hematology Oncology Consultants | |
| Indianapolis, Indiana, United States, 46202 | |
| Central Indiana Cancer Centers | |
| Indianapolis, Indiana, United States, 46227 | |
| United States, Iowa | |
| Oncology Associates of Cedar Rapids | |
| Cedar Rapids, Iowa, United States, 52403 | |
| United States, Kansas | |
| Kansas City Cancer Centers - Southwest | |
| Overland Park, Kansas, United States, 66210 | |
| United States, Louisiana | |
| LSU Health Science Center, Stanley S. Scott Cancer Center | |
| New Orleans, Louisiana, United States, 70112 | |
| Louisiana Oncology Associates | |
| Lafayette, Louisiana, United States, 70506 | |
| United States, Maine | |
| Maine Center for Cancer Medicine & Blood Disorders | |
| Scarborough, Maine, United States, 04074 | |
| United States, Massachusetts | |
| Berkshire Hematology Oncology | |
| Pittsfield, Massachusetts, United States, 01201 | |
| United States, Michigan | |
| Karmanos Cancer Institute, Wayne State University | |
| Detroit, Michigan, United States, 48201 | |
| United States, Minnesota | |
| Maplewood Cancer Center | |
| Maplewood, Minnesota, United States, 55404 | |
| Virginia Piper Cancer Institute | |
| Minneapolis, Minnesota, United States, 55407 | |
| United States, Missouri | |
| Hematology/Oncology Consultants, Inc. | |
| St. Louis, Missouri, United States, 63136 | |
| St. Joseph Oncology, Inc. | |
| St. Joseph, Missouri, United States, 64507 | |
| Arch Medical Services, Inc. | |
| Washington, Missouri, United States, 63090 | |
| Missouri Cancer Associates | |
| Columbia, Missouri, United States, 65201 | |
| Capitol Comprehensive Cancer Care Clinic | |
| Jefferson City, Missouri, United States, 65109 | |
| United States, Nebraska | |
| Nebraska Methodist Hospital Cancer Center | |
| Omaha, Nebraska, United States, 68114 | |
| United States, Nevada | |
| Nevada Cancer Institute | |
| Las Vegas, Nevada, United States, 89135 | |
| Comprehensive Cancer Centers of Nevada | |
| Las Vegas, Nevada, United States, 89109 | |
| United States, New Hampshire | |
| New Hampshire Oncology-Hematology PA | |
| Hooksett, New Hampshire, United States, 03106 | |
| United States, New Mexico | |
| Veterans Affairs Medical Center | |
| Albuquerque, New Mexico, United States, 87108 | |
| Hematology Oncology Associates | |
| Albuquerque, New Mexico, United States, 87106 | |
| The University of New Mexico | |
| Albuquerque, New Mexico, United States, 87131-0001 | |
| New Mexico Cancer Care Associates | |
| Santa Fe, New Mexico, United States, 87505 | |
| Lovelace Sandia Health Systems | |
| Albuquerque, New Mexico, United States, 87108 | |
| United States, New York | |
| Albany Regional Cancer Center | |
| Albany, New York, United States, 12208 | |
| Interlakes Oncology Hematology | |
| Canandaigua, New York, United States, 14623 | |
| New York Oncology Hematology, P.C. | |
| Albany, New York, United States, 12208 | |
| Advanced Oncology Associates | |
| Armonk, New York, United States, 10504 | |
| Roswell Park Cancer Institute | |
| Buffalo, New York, United States, 14263 | |
| VA Medical Center Syracuse | |
| Syracuse, New York, United States, 13210 | |
| Columbia Presbyterian Medical Center | |
| New York, New York, United States, 10032 | |
| New York Oncology Hematology | |
| Rexford, New York, United States, 12148 | |
| United States, North Carolina | |
| Piedmont Hematology - Oncology | |
| Winston - Salem, North Carolina, United States, 27103 | |
| Raleigh Hematology Oncology Clinic | |
| Cary, North Carolina, United States, 27511 | |
| United States, Ohio | |
| Dayton Oncology Hematology | |
| Kettering, Ohio, United States, 45067 | |
| United States, Oklahoma | |
| Cancer Care Associates | |
| Oklahoma City, Oklahoma, United States, 73120 | |
| Cancer Care Associates | |
| Tulsa, Oklahoma, United States, 74136 | |
| United States, Oregon | |
| Willamette Valley Cancer Center | |
| Eugene, Oregon, United States, 97401 | |
| United States, Pennsylvania | |
| Hematology and Oncology Associates of Northeastern PA / PC | |
| Dunmore, Pennsylvania, United States, 18512 | |
| University of Pennsylvania Abramson Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| University of Pittsburgh Cancer Institute- Hillman Cancer Center | |
| Pittsburgh, Pennsylvania, United States, 15232 | |
| United States, South Carolina | |
| Cancer Center of the Carolinas, Seneca | |
| Seneca, South Carolina, United States, 29672 | |
| Medical University of South Carolina Hollings Cancer Center | |
| Charleston, South Carolina, United States, 29425 | |
| Charleston Cancer Center | |
| Charleston, South Carolina, United States, 29406 | |
| United States, Tennessee | |
| The West Clinic | |
| Memphis, Tennessee, United States, 38120 | |
| United States, Texas | |
| Allison Cancer Center | |
| Midland, Texas, United States, 79701 | |
| Texas Cancer Center at Medical City | |
| Dallas, Texas, United States, 75230 | |
| Hematology Oncology Associates of South Texas | |
| San Antonio, Texas, United States, 78229 | |
| Lake Vista Cancer Center | |
| Lewisville, Texas, United States, 75067 | |
| Longview Cancer Center | |
| Longview, Texas, United States, 75601 | |
| Mamie McFaddin Ward Cancer Center | |
| Beaumont, Texas, United States, 77702 | |
| El Paso Cancer Treatment Center | |
| El Paso, Texas, United States, 79915 | |
| Texas Cancer Center of Mesquite | |
| Mesquite, Texas, United States, 75150 | |
| Texas Cancer Center | |
| Abilene, Texas, United States, 79606 | |
| Texas Oncology Cancer Center | |
| Austin, Texas, United States, 78731 | |
| Texas Oncology, P.A. - Irving | |
| Irving, Texas, United States, 75601 | |
| Texas Oncology, P.A. | |
| Garland, Texas, United States, 75042 | |
| Texas Oncology, P.A. | |
| Ft. Worth, Texas, United States, 76104 | |
| Waco Cancer Care Research Center | |
| Waco, Texas, United States, 76712 | |
| San Antonio Tumor & Blood Clinic | |
| Fredericksburg, Texas, United States, 78624 | |
| Tyler Cancer Center | |
| Tyler, Texas, United States, 75702 | |
| S. Texas Cancer Center | |
| McAllen, Texas, United States, 78503 | |
| West Texas Cancer Center | |
| Odessa, Texas, United States, 79761 | |
| Southwest Regional Cancer Center | |
| Austin, Texas, United States, 78705 | |
| The Texas Cancer Center | |
| Dallas, Texas, United States, 75237 | |
| Texas Oncology, P.A. - Deke Slayton Cancer Center | |
| Webster, Texas, United States, 77598 | |
| Texas Oncology, P.A. | |
| Dallas, Texas, United States, 75231-1449 | |
| El Paso Cancer Treatment Center | |
| El Paso, Texas, United States, 79915 | |
| Texas Oncology | |
| Arlington, Texas, United States, 76012 | |
| TOPA Sammons Cancer Center | |
| Dallas, Texas, United States, 75246 | |
| Texas Cancer Center | |
| Denton, Texas, United States, 76210 | |
| Texas Onoclogy PA - Bedford | |
| Bedford, Texas, United States, 76022 | |
| United States, Virginia | |
| Onc and Hem Associates of SW VA, Inc. | |
| Salem, Virginia, United States, 24153 | |
| Virginia Oncology Associates | |
| Norfolk, Virginia, United States, 23501 | |
| United States, Washington | |
| Cancer Care Northwest-North | |
| Spokane, Washington, United States, 99218 | |
| Northwest Cancer Specialists | |
| Vancouver, Washington, United States, 98684 | |
| Puget Sound Cancer Center - Edmonds | |
| Edmonds, Washington, United States, 98026 | |
| United States, Wisconsin | |
| Froedtert Memorial Lutheran Hospital | |
| Milwaukee, Wisconsin, United States, 53226 | |
| Argentina | |
| Hospital Italiano Regional del Sur Dept. Oncology | |
| Bahia Blanca, Argentina, B8001HXM | |
| Grupo Plaza Dept. Oncology | |
| Belen de Escobar, Argentina, B1625FWI | |
| Caici Dept. Oncology | |
| Rosario, Argentina, S2000DSK | |
| Hospital Italiano de Cordoba Dept. Oncology | |
| Cordoba, Argentina, X5004BAL | |
| Clinical Especializada ISIS | |
| Santa Fe, Argentina, S3000FFU | |
| Instituto Alexander Fleming | |
| Buenos Aires, Argentina, C1426ANZ | |
| Instituto Quirúrgico del Callao | |
| Buenos Aires, Argentina, C1022AAE | |
| Centro Oncológico LALCEC | |
| Concepcion del Uruguay, Entre Ríos, Argentina, E3260FPB | |
| Centro San Roque | |
| San Miguel de Tucumán, Tucumán, Argentina, T4000IAK | |
| Unidad Oncologica del Neuquen | |
| Neuquen, Argentina, Q8300HDH | |
| Centro Oncologico Rosario | |
| Rosario, Argentina, S2000DSK | |
| Argentina, Buenos Aires | |
| Hospital General de Agudos E. Tornu | |
| Capital Federal, Buenos Aires, Argentina, C1427ARN | |
| Salisbury Investigaciones Clinicas del Grupo CER S.A. | |
| Quilmes, Buenos Aires, Argentina, B1878DVB | |
| Clinica Oncologica de Excelencia | |
| Capital Federal, Buenos Aires, Argentina, C1405CBA | |
| Policlinica Bancaria "9 de Julio" Av. Gaona 2197 | |
| Capital Federal, Buenos Aires, Argentina, C1416DRJ | |
| Hospital Italiano de Buenos Aires | |
| Capital Federal, Buenos Aires, Argentina, C1181ACH | |
| Belgium | |
| Institut Jules Bordet Service de Chimiothérapie | |
| Bruxelles, Belgium, B-1000 | |
| Hopital Erasme | |
| Bruxelles, Belgium, B-1070 | |
| Sint Maartenziekenhuis | |
| Kortrijk, Belgium, 8500 | |
| UCLC St. Luc | |
| Bruxelles, Belgium, B-1200 | |
| AZ-VUB | |
| Bruxelles, Belgium, 1090 | |
| Croatia | |
| Clinical Hostpital Rebro Department of Oncology | |
| Zagreb, Croatia, 10000 | |
| Clinical Hospital Split Department of Oncology and Radiotherapy | |
| Split, Croatia, 21000 | |
| France | |
| Hôpital Tenon | |
| Paris, France, 75020 | |
| CHU de Poitiers | |
| Poitiers, France, 86021 | |
| Centre Hospitalier Départemental | |
| La Roche Sur Yon, France, 85025 | |
| CRLC Val d'Aurelle Paul-Lamarque | |
| Montpellier, France, 34298 | |
| CHU de Bicêtre | |
| Le Kremlin Bicetre, France, 94278 | |
| Centre Georges François Leclerc | |
| Dijon, France, 21079 | |
| Institut Bergonié | |
| Bordeaux Cedex, France, 33076 | |
| CRLC Léon Bérard | |
| Lyon, France, 69373 | |
| Institut Jean , Service d'Oncologie | |
| Reims, France, 51100 | |
| Centre Alexis Vautrin | |
| Vandoeuvre Les Nancy, France, 54500 | |
| Hôpital Saint-Louis: Service de Radiotherapy | |
| Paris, France, 75010 | |
| Chu Dupuytren | |
| Limoges, France, 87000 | |
| Hôpital de La Tronche - CHU de Grenoble: Departement de cacerologie et d'hematologie | |
| Grenoble Cedex 09, France, 38043 | |
| Clinique du Mail Service d'Oncologie | |
| Grenoble, France, 38100 | |
| Centre Eugene Marquis | |
| Rennes Cedex, France, 35042 | |
| Centre Hospitalier Belfort-Montbeliard | |
| Montbeliard, France, 25209 | |
| Centre Antoine Lacassagne Oncologie medicale | |
| Nice Cedex 2, France, 06189 | |
| Germany | |
| Stadtische Klinicen Frankfurt a.M. Hochst | |
| Frankfurt a.M. Hochst, Germany, 65929 | |
| Klinikum rechts der Isar | |
| München, Germany, 81675 | |
| Klinik Bad Trissel | |
| Oberaudorf, Germany, 83080 | |
| EuromedClinic | |
| Fürth, Germany, 90763 | |
| Universitätsklinikum der Carl-Gustav-Carus Universität | |
| Dresden, Germany, 01307 | |
| Klinikum der medizinischen Fakultät der Martin-Luther-Universität Halle-Wittenberg | |
| Halle, Germany, 06120 | |
| Diakonissenkrankenhaus Dessau gGmbH | |
| Dessau, Germany, 06846 | |
| Fach- und Belegarzte fur Urologie | |
| Berlin, Germany, 14197 | |
| Medizinische Hochschule | |
| Hannover, Germany, 30625 | |
| Klinikum der Philipps - Universitat Marburg | |
| Marburg, Germany, 35043 | |
| RWTH Aachen | |
| Aachen, Germany, 52074 | |
| Vivantes Krankenhaus am Urban | |
| Berlin, Germany, 10967 | |
| Niedergelassener Urologe | |
| Hamburg, Germany, 22399 | |
| Marienhospital II | |
| Herne, Germany, 44627 | |
| Klinickum der Johannes-Gutenberg Universitat | |
| Mainz, Germany, 55131 | |
| Universitatklinikum Munster | |
| Munster, Germany, 48129 | |
| Universitatklinikum Schleswig-Holstein | |
| Lubeck, Germany, 23538 | |
| Urologische Praxis | |
| Saarbrücken, Germany, 04416 | |
| Hungary | |
| St. Margit Hospital | |
| Budapest, Hungary, 1032 | |
| National Institute of Oncology | |
| Budapest, Hungary, 1122 | |
| Pecs Medical University | |
| Pecs, Hungary, 7601 | |
| St. Istvan Hospital | |
| Budapest, Hungary, 1096 | |
| Israel | |
| Rambam Medical Center | |
| Haifa, Israel, 31096 | |
| Soroka Medical Center | |
| Beerhseva, Israel, 84101 | |
| Hadassah University | |
| Jerusalem, Israel, 91120 | |
| Hospital Ein Kerem Asaf Harofeh Medical Center | |
| Zerifin, Israel, 70300 | |
| Italy | |
| A.O. San Camillo-Forlanini | |
| Rome, Italy, 00152 | |
| Istituto Nazionale per la Ricerca sul Cancro (IST) | |
| Genoa, Italy, 16132 | |
| A.S.O. San Luigi | |
| Orbassano, Italy, 10043 | |
| Istituto Clinico Humanitas: Dipartimento di Oncologia Medica ed Ematologia | |
| Rozanno (MI), Italy, 20089 | |
| Azienda Ospedaliera di Padova | |
| Padova, Italy, 35128 | |
| Universita degli Studi di Napoli Federico II-Nuovo Policlinico | |
| Napoli, Italy, 80131 | |
| Netherlands | |
| Streekziekenhuis Koningin : Dept. Urology | |
| Winterswijk, Netherlands, 7101 BN | |
| Academisch Ziekenhuis Nijmegen: Urology Department | |
| Nijmegen, Netherlands, GA-6525 | |
| Academic Hospital of the University of Amsterdam | |
| Amsterdam, Netherlands, 1105 AZ | |
| Peru | |
| Essalud Dept. Oncology | |
| Jesus Maria, Peru, 11 | |
| INEN Dept Onco-Hemato | |
| Lima, Peru, 34 | |
| San Felipe (Oncomedical) | |
| Lima, Peru, 11 | |
| Poland | |
| Akademia Medyczna w Lublinie | |
| Lublin, Poland, 20-954 | |
| Akademia Medyczna w Lodzi | |
| Lodz, Poland, 93-509 | |
| Akademia Medyczna w Szczecinie | |
| Szczecin, Poland, 70-111 | |
| Oddzial Chemioterapii, Bialostocki Osrodek Onkologiczny | |
| Bialystok, Poland, 15-027 | |
| Oddzial Chemioterapii, 4 Wojskowy Szpital Kliniczny | |
| Wroclaw, Poland, 50-981 | |
| Oddzial Onkologii I Radioterapii, Szpital Morski im. PCK | |
| Gdynia, Poland, 81-519 | |
| Oddzial Radioterapii, Wielkopolskie Centrum Onkologii - Instytut | |
| Poznan, Poland, 61-866 | |
| Klinika Nowotworow Ukladu Moczowego, Centrum Onkologii - Instytut | |
| Warszawa, Poland, 02-781 | |
| Russian Federation | |
| N.N Blokchin Cancer Research Centre | |
| Moscow, Russian Federation, 115478 | |
| Medical Radilogical Research Center of Rams | |
| Obninsk, Russian Federation, 249036 | |
| Hertzen Research Institute of Oncology | |
| Moscow, Russian Federation, 125284 | |
| Spain | |
| Instituto Valenciano de Oncología: Sevicio de Oncología Médica | |
| Valencia, Spain, 46009 | |
| Hospital Clínico San Carlos, Sevicio de Oncología Médica | |
| Madrid, Spain, 28040 | |
| Clinica Universitaria de Navarra, Sevicio de Oncología Médica | |
| Pamplona, Spain, 31008 | |
| Hospital Universitario Marqués de Valdecilla, Sevicio de Oncología Médica | |
| Santander, Spain, 39008 | |
| Hospital de la Santa Creu i Sant Pau, Sevicio de Oncología Médica | |
| Barcelona, Spain, 08025 | |
| Hospital Clinic i Provincial, Sevicio de Oncología Médica | |
| Barcelona, Spain, 08036 | |
| Hospital Ramon y Cajal | |
| Madrid, Spain, 20034 | |
| United Kingdom | |
| St. Bartholomew's Hospital Dept. of Medical Oncology | |
| London, United Kingdom | |
| Bristol Oncology Centre | |
| Bristol, United Kingdom, BS2 8 ED | |
| Guy's hospital | |
| London, United Kingdom, SE19RT | |
| CRUK Institute for Cancer Studies | |
| Birmingham, United Kingdom, B152TT | |
| Beatson Oncology Center | |
| Glasgow, United Kingdom, G11 6NT | |
| Northern Centre for Cancer Treatment | |
| Newcastle Upon Tyne, United Kingdom, NE4 6BE | |
| Aberdeen Royal Infirmary | |
| Aberdeen, United Kingdom, AB25 2ZN | |
| Lister Hospital Department of Urology | |
| Stevenage Hertfordshire, United Kingdom, SG1 4 AB | |
| St George's Healthcare Dept of Oncology, Tooting | |
| London, United Kingdom, SW17 0QT | |
| Royal Marsden Hospital | |
| Sutton, United Kingdom, SM25PT | |
More Information
| Study ID Numbers: | GPC SAT3-03-01 |
| Study First Received: | September 30, 2003 |
| Last Updated: | September 10, 2007 |
| ClinicalTrials.gov Identifier: | NCT00069745 History of Changes |
| Health Authority: | United States: Food and Drug Administration |
|
Prostatic Neoplasms Cancer Treatment Protocols Antineoplastic protocols |
|
Anti-Inflammatory Agents Prednisone Satraplatin Antineoplastic Agents, Hormonal Genital Neoplasms, Male Prostatic Diseases Antineoplastic Agents Physiological Effects of Drugs Hormones, Hormone Substitutes, and Hormone Antagonists |
Urogenital Neoplasms Genital Diseases, Male Glucocorticoids Hormones Pharmacologic Actions Neoplasms Neoplasms by Site Therapeutic Uses Prostatic Neoplasms |
