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Study Comparing the Safety and Efficacy of Piperacillin/Tazobactam to Cefepime in Patients With Hematologic Malignancy or Lymphoma
This study has been completed.
First Received: September 4, 2002   Last Updated: October 8, 2007   History of Changes
Sponsor: Wyeth
Information provided by: Wyeth
ClinicalTrials.gov Identifier: NCT00044759
  Purpose

To compare the safety and efficacy of piperacillin/tazobactam (4 g/500 mg) administered intravenously every 6 hours to cefepime (2 g) administered intravenously every 8 hours for the empiric treatment of neutropenic fever in patients with a hematologic malignancy or lymphoma.


Condition Intervention Phase
Hematologic Neoplasms
Drug: Piperacillin/Tazobactam (Tazocin)
Phase III

Study Type: Interventional
Study Design: Treatment
Official Title: A Randomized, Open-Label, Multi-Center, Comparative Study of the Efficacy and Safety of Piperacillin/Tazobactam to Cefepime for the Empiric Treatment of Neutropenic Fever in Patients With a Hematologic Malignancy or Lymphoma

Resource links provided by NLM:


Further study details as provided by Wyeth:

Study Completion Date: January 2003
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Hospitalized male and female patients, 18 years of age or older
  • Patients who have leukemia (acute lymphocytic leukemia [ALL], acute myelogenous leukemia [AML], chronic lymphocytic leukemia [CLL], chronic myelogenous leukemia [CML]), that is newly diagnosed, who have had initial induction, re-induction, or intensification chemotherapy or who have had a bone marrow (allogenic, syngeneic, or autologous) or peripheral blood stem-cell transplant OR Patients with lymphoma, Hodgkin's disease, multiple myeloma, myelodysplastic syndrome or myelodysplasia (refractory anemia [RA], refractory anemia with ringed sideroblasts [RARS], refractory anemia with excess blasts [RAEB], refractory anemia with excess blasts in transformation to leukemia [RAEB-T], or chronic myelomonocytic leukemia [CMML].
  • Fever, defined as an oral temperature of ≥ 37.9°C /100.2°F, a rectal temperature ≥ 38.4°C /101.4°F, or a tympanic temperature ≥ 38°C /100.4°F

Exclusion Criteria:

  • The presence of any clinically acute or chronic disease or condition that, in the opinion of the investigator, may interfere with the patient's ability to safely comply with the conditions of the protocol, or could preclude the evaluation of the patient's response or could make the completion of the therapy unlikely
  • Neutropenia associated with syndromes that are not associated with a high risk of bacterial infection (eg. chronic benign neutropenia or Kostmann's syndrome)
  • Neutropenia due to primary bone marrow failure
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00044759

  Hide Study Locations
Locations
United States, Arkansas
Little Rock, Arkansas, United States, 72205
United States, California
Los Angeles, California, United States, 90089
United States, Colorado
Denver, Colorado, United States, 80205
United States, Florida
Ocala, Florida, United States, 34474
Gainesville, Florida, United States, 32610
North Miami, Florida, United States, 33169
St. Petersburg, Florida, United States, 33705
United States, Georgia
Thomasville, Georgia, United States, 31792
United States, Illinois
Chicago, Illinois, United States, 60637
Chicago, Illinois, United States, 60611
United States, Iowa
Iowa City, Iowa, United States, 52242
United States, Kentucky
Louisville, Kentucky, United States, 40202
United States, New Jersey
Camden, New Jersey, United States, 08103
Hackensack, New Jersey, United States, 7601
United States, New York
Rochester, New York, United States, 14621
Bronx, New York, United States, 10466
Buffalo, New York, United States, 14263
New York, New York, United States, 10021
Rochester, New York, United States, 14642-8668
Valhalla, New York, United States, 10595
United States, Oklahoma
Tulsa, Oklahoma, United States, 74136
United States, Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
West Reading, Pennsylvania, United States, 19611
Philadelphia, Pennsylvania, United States, 19107
Sayre, Pennsylvania, United States, 18840
Upland, Pennsylvania, United States, 19013
United States, Rhode Island
Providence, Rhode Island, United States, 02908
United States, South Carolina
Columbia, South Carolina, United States, 29203
United States, Texas
Houston, Texas, United States, 77030
United States, West Virginia
Morgantown, West Virginia, United States, 26506-9162
United States, Wisconsin
Milwaukee, Wisconsin, United States, 53226
Canada
Saskatoon, Canada, S7N 0W8
Winnepeg, Canada, R3A 1r9
Ottawa, Canada, K1H 8L6
Montreal, Canada, H1T 2M4
Hamilton, Canada
Sponsors and Collaborators
Wyeth
Investigators
Study Director: Medical Monitor, MD Wyeth
  More Information

No publications provided

Study ID Numbers: 0910B1-308
Study First Received: September 4, 2002
Last Updated: October 8, 2007
ClinicalTrials.gov Identifier: NCT00044759     History of Changes
Health Authority: United States: Food and Drug Administration

Keywords provided by Wyeth:
Hematologic
Neoplasms

Additional relevant MeSH terms:
Anti-Infective Agents
Neoplasms by Histologic Type
Immunoproliferative Disorders
Molecular Mechanisms of Pharmacological Action
Hematologic Neoplasms
Immune System Diseases
Hematologic Diseases
Enzyme Inhibitors
Tazobactam
Piperacillin-tazobactam combination product
Pharmacologic Actions
Anti-Bacterial Agents
Lymphatic Diseases
Neoplasms
Neoplasms by Site
Penicillanic Acid
Therapeutic Uses
Piperacillin
Lymphoproliferative Disorders
Lymphoma

ClinicalTrials.gov processed this record on November 22, 2009