Inclusion Criteria:

• Measurable disease as defined by the presence of at least one measurable lesion
• Failed at least one prior therapy or has achieved remission but has progressed or relapsed within 6 months of therapy
• Life expectancy of at least 12 weeks
• Adequate bone marrow, liver and kidney function

Exclusion Criteria:

• Excluded medical conditions like: pre-existing neuropathy, active heart diseases or ischemia, serious infections, HIV infection, chronic hepatitis B or C, seizures, hypersensitivity to taxanes, organ transplants, some previous cancers
• Excluded therapies and medications, previous and concomitant such as: anticancer chemotherapy or immunotherapy during the study or within 4 weeks prior to study entry; more than two prior anticancer chemotherapy regimens; radiotherapy during study or within 4 weeks prior to study entry; bone marrow transplant
• Others: pregnant or breast-feeding patients; both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial; substance abuse, medical, psychological or social conditions that may interfere with the patient's participation