|
Home
Search
Study Topics
Glossary
|
![]() |
![]() |
|
![]() |
|
![]() |
|
![]() |
![]() |
![]() |
|
![]() |
![]() |
||||||||||||||||||||||||||||||||||||
| Sponsor: | European Organization for Research and Treatment of Cancer |
|---|---|
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00030680 |
Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients who have aggressive fibromatoses.
| Condition | Intervention | Phase |
|---|---|---|
|
Desmoid Tumor |
Radiation: radiation therapy |
Phase II |
| Study Type: | Interventional |
| Study Design: | Treatment |
| Official Title: | Phase II Pilot Study Of Moderate Dose Radiotherapy For Inoperable Aggressive Fibromatoses |
| Estimated Enrollment: | 40 |
| Study Start Date: | November 2001 |
OBJECTIVES:
OUTLINE: This is a multicenter study.
Patients receive radiotherapy 5 days a week for 5.5 weeks for a total of 56 Gy in 28 fractions.
Patients are followed every 3 months for 2 years and then every 6 months thereafter.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 3 years.
Eligibility| Ages Eligible for Study: | 16 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed aggressive fibromatoses arising in any site
Primary, recurrent, or progressive disease that is inoperable or requires a major operation resulting in a large functional or cosmetic deficit or mutilation
Incompletely resected tumor with gross residual disease not suitable for further surgery
Lesions must be suitable for radiotherapy
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
Other:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
Contacts and Locations| Belgium | |
| Cliniques Universitaires Saint-Luc | |
| Brussels, Belgium, 1200 | |
| Universitair Ziekenhuis Antwerpen | |
| Edegem, Belgium, B-2650 | |
| France | |
| Centre Leon Berard | |
| Lyon, France, 69008 | |
| CHU de la Timone | |
| Marseille, France, 13385 | |
| Institut Bergonie | |
| Bordeaux, France, 33076 | |
| Germany | |
| Southwest German Cancer Center at Eberhard-Karls-University | |
| Tuebingen, Germany, D-72076 | |
| Netherlands | |
| Arnhems Radiotherapeutisch Instituut | |
| Arnhem, Netherlands, 6815 AD | |
| Daniel Den Hoed Cancer Center at Erasmus Medical Center | |
| Rotterdam, Netherlands, 3008 AE | |
| Dr. Bernard Verbeeten Instituut | |
| Tilburg, Netherlands, 5042 SB | |
| Leiden University Medical Center | |
| Leiden, Netherlands, 2300 RC | |
| Maastro Clinic - Locatie Maastricht | |
| Maastricht, Netherlands, NL-6229 ET | |
| University Medical Center Groningen | |
| Groningen, Netherlands, 9700 RB | |
| Poland | |
| Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology | |
| Warsaw, Poland, 02-781 | |
| Switzerland | |
| Centre Hospitalier Universitaire Vaudois | |
| Lausanne, Switzerland, CH-1011 | |
| United Kingdom, England | |
| Cancer Research Centre at Weston Park Hospital | |
| Sheffield, England, United Kingdom, S1O 2SJ | |
| Christie Hospital | |
| Manchester, England, United Kingdom, M20 4BX | |
| Royal Marsden - Surrey | |
| Sutton, England, United Kingdom, SM2 5PT | |
| Mount Vernon Cancer Centre at Mount Vernon Hospital | |
| Northwood, England, United Kingdom, HA6 2RN | |
| Nottingham City Hospital NHS Trust | |
| Nottingham, England, United Kingdom, NG5 1PB | |
| Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust | |
| Birmingham, England, United Kingdom, B15 2TH | |
| Cookridge Hospital | |
| Leeds, England, United Kingdom, LS16 6QB | |
| Investigator: | R. B. Keus, MD | Arnhems Radiotherapeutisch Instituut |
| Investigator: | Thomas Schnabel, MD | Klinikum der Stadt Ludwigshafen am Rhein |
More Information
| Study ID Numbers: | CDR0000069188, EORTC-62991, EORTC-22998 |
| Study First Received: | February 14, 2002 |
| Last Updated: | February 6, 2009 |
| ClinicalTrials.gov Identifier: | NCT00030680 History of Changes |
| Health Authority: | United States: Federal Government |
|
desmoid tumor |
|
Neoplasms, Connective and Soft Tissue Neoplasms Neoplasms by Histologic Type Fibromatosis, Aggressive |
Fibroma Neoplasms, Connective Tissue Neoplasms, Fibrous Tissue |