Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia
Recruitment status was Active, not recruiting
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective for treating infants with acute lymphoblastic leukemia.
PURPOSE: Randomized phase III trial to compare the effectiveness of different combination chemotherapy regimens in treating infants who have newly diagnosed acute lymphoblastic leukemia.
Drug: daunorubicin hydrochloride
Drug: leucovorin calcium
Drug: vincristine sulfate
Procedure: allogeneic bone marrow transplantation
|Study Design:||Primary Purpose: Treatment|
|Official Title:||International Collaborative Treatment Protocol for Infants Under One Year With Acute Lymphoblastic Leukemia|
- Event-free survival at 3-4 years after diagnosis [ Designated as safety issue: No ]
|Study Start Date:||May 1999|
Show 33 Study Locations
|Study Chair:||Rob Pieters, MD, MSC, PhD||Erasmus MC - Sophia Children's Hospital|